Timothy F. Osborne - Publications

University of California, Irvine, Irvine, CA 
Molecular Biology

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kim DK, Kim YH, Lee JH, Jung YS, Kim J, Feng R, Jeon TI, Lee IK, Cho SJ, Im SS, Dooley S, Osborne TF, Lee CH, Choi HS. Estrogen-related receptor γ controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 158521. PMID 31479733 DOI: 10.1016/j.bbalip.2019.158521  0.32
2018 Lee JH, Phelan P, Shin M, Oh BC, Han X, Im SS, Osborne TF. SREBP-1a-stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1. Proceedings of the National Academy of Sciences of the United States of America. PMID 30530672 DOI: 10.1073/pnas.1813458115  0.32
2016 Kim KY, Jang HJ, Yang YR, Park KI, Seo J, Shin IW, Jeon TI, Ahn SC, Suh PG, Osborne TF, Seo YK. Corrigendum: SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy. Scientific Reports. 6: 37794. PMID 27897271 DOI: 10.1038/srep37794  0.4
2016 Kim KY, Jang HJ, Yang YR, Park KI, Seo J, Shin IW, Jeon TI, Ahn SC, Suh PG, Osborne TF, Seo YK. SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy. Scientific Reports. 6: 35732. PMID 27767079 DOI: 10.1038/srep35732  0.4
2015 Matsumura Y, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J. H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation. Molecular Cell. 60: 584-96. PMID 26590716 DOI: 10.1016/j.molcel.2015.10.025  0.4
2015 Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, ... Osborne TF, et al. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Nature Communications. 6: 7052. PMID 25948511 DOI: 10.1038/ncomms8052  0.4
2015 Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, et al. The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis. The Journal of Biological Chemistry. 290: 4163-77. PMID 25533466 DOI: 10.1074/jbc.M114.626929  0.4
2014 Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Deng C, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P. Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell. 158: 659-72. PMID 25083875 DOI: 10.1016/j.cell.2014.06.050  0.4
2014 Im SS, Young SG, Raffatellu M, Osborne TF. Response to Gerlic et al. Cell Metabolism. 19: 346-7. PMID 24606892 DOI: 10.1016/j.cmet.2014.02.016  0.32
2013 Jeon TI, Esquejo RM, Roqueta-Rivera M, Phelan PE, Moon YA, Govindarajan SS, Esau CC, Osborne TF. An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis. Cell Metabolism. 18: 51-61. PMID 23823476 DOI: 10.1016/j.cmet.2013.06.010  0.4
2013 Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ. Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nature Immunology. 14: 489-99. PMID 23563690 DOI: 10.1038/ni.2570  0.4
2012 Im SS, Osborne TF. Protection from bacterial-toxin-induced apoptosis in macrophages requires the lipogenic transcription factor sterol regulatory element binding protein 1a. Molecular and Cellular Biology. 32: 2196-202. PMID 22493063 DOI: 10.1128/MCB.06294-11  0.32
2012 Chong HK, Biesinger J, Seo YK, Xie X, Osborne TF. Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR. Bmc Genomics. 13: 51. PMID 22296850 DOI: 10.1186/1471-2164-13-51  0.4
2012 Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell. 148: 244-58. PMID 22265415 DOI: 10.1016/j.cell.2011.12.017  0.4
2011 Jeong YS, Kim D, Lee YS, Kim HJ, Han JY, Im SS, Chong HK, Kwon JK, Cho YH, Kim WK, Osborne TF, Horton JD, Jun HS, Ahn YH, Ahn SM, et al. Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression. Plos One. 6: e22544. PMID 21811631 DOI: 10.1371/journal.pone.0022544  0.4
2011 Jeon TI, Seo YK, Osborne TF. Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK. The Biochemical Journal. 438: 33-7. PMID 21592089 DOI: 10.1042/BJ20110009  0.4
2011 Im SS, Yousef L, Blaschitz C, Liu JZ, Edwards RA, Young SG, Raffatellu M, Osborne TF. Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metabolism. 13: 540-9. PMID 21531336 DOI: 10.1016/j.cmet.2011.04.001  0.32
2011 Im SS, Osborne TF. Liver x receptors in atherosclerosis and inflammation. Circulation Research. 108: 996-1001. PMID 21493922 DOI: 10.1161/CIRCRESAHA.110.226878  0.32
2011 Seo YK, Jeon TI, Chong HK, Biesinger J, Xie X, Osborne TF. Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy. Cell Metabolism. 13: 367-75. PMID 21459322 DOI: 10.1016/j.cmet.2011.03.005  0.4
2010 Lee FY, de Aguiar Vallim TQ, Chong HK, Zhang Y, Liu Y, Jones SA, Osborne TF, Edwards PA. Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. Molecular Endocrinology (Baltimore, Md.). 24: 1626-36. PMID 20573685 DOI: 10.1210/me.2010-0117  0.4
2010 Chong HK, Infante AM, Seo YK, Jeon TI, Zhang Y, Edwards PA, Xie X, Osborne TF. Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1. Nucleic Acids Research. 38: 6007-17. PMID 20483916 DOI: 10.1093/nar/gkq397  0.4
2010 Huang Y, He S, Li JZ, Seo YK, Osborne TF, Cohen JC, Hobbs HH. A feed-forward loop amplifies nutritional regulation of PNPLA3. Proceedings of the National Academy of Sciences of the United States of America. 107: 7892-7. PMID 20385813 DOI: 10.1073/pnas.1003585107  0.4
2009 Osborne TF, Espenshade PJ. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes & Development. 23: 2578-91. PMID 19933148 DOI: 10.1101/gad.1854309  0.4
2009 Seo YK, Chong HK, Infante AM, Im SS, Xie X, Osborne TF. Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif. Proceedings of the National Academy of Sciences of the United States of America. 106: 13765-9. PMID 19666523 DOI: 10.1073/pnas.0904246106  0.4
2009 Im SS, Hammond LE, Yousef L, Nugas-Selby C, Shin DJ, Seo YK, Fong LG, Young SG, Osborne TF. Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2. Molecular and Cellular Biology. 29: 4864-72. PMID 19564420 DOI: 10.1128/MCB.00553-09  0.4
2009 Seo YK, Zhu B, Jeon TI, Osborne TF. Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin. Experimental Cell Research. 315: 3133-9. PMID 19500568 DOI: 10.1016/j.yexcr.2009.05.025  0.4
2008 Jeon TI, Zhu B, Larson JL, Osborne TF. SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice Journal of Clinical Investigation. 118: 3693-3700. PMID 18846256 DOI: 10.1172/JCI36461  0.4
2008 Choi WI, Jeon BN, Park H, Yoo JY, Kim YS, Koh DI, Kim MH, Kim YR, Lee CE, Kim KS, Osborne TF, Hur MW. Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN). The Journal of Biological Chemistry. 283: 29341-54. PMID 18682402 DOI: 10.1074/jbc.M802477200  0.4
2008 Bennett MK, Seo YK, Datta S, Shin DJ, Osborne TF. Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver. The Journal of Biological Chemistry. 283: 15628-37. PMID 18413311 DOI: 10.1074/jbc.M800391200  0.4
2008 Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, et al. Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP. The Journal of Clinical Investigation. 118: 259-71. PMID 18060044 DOI: 10.1172/JCI32011  0.4
2007 Lee H, Hubbert ML, Osborne TF, Woodford K, Zerangue N, Edwards PA. Regulation of the sodium/sulfate co-transporter by farnesoid X receptor alpha. The Journal of Biological Chemistry. 282: 21653-61. PMID 17545158 DOI: 10.1074/jbc.M700897200  0.4
2007 Matsukuma KE, Wang L, Bennett MK, Osborne TF. A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor. The Journal of Biological Chemistry. 282: 20164-71. PMID 17522048 DOI: 10.1074/jbc.M702895200  0.52
2006 Matsukuma KE, Bennett MK, Huang J, Wang L, Gil G, Osborne TF. Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase. Journal of Lipid Research. 47: 2754-61. PMID 16957179 DOI: 10.1194/jlr.M600342-JLR200  0.52
2006 Datta S, Wang L, Moore DD, Osborne TF. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake. The Journal of Biological Chemistry. 281: 807-12. PMID 16282330 DOI: 10.1074/jbc.M511050200  1
2005 Zoumi A, Datta S, Liaw LH, Wu CJ, Manthripragada G, Osborne TF, Lamorte VJ. Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer. Molecular and Cellular Biology. 25: 2946-56. PMID 15798184 DOI: 10.1128/MCB.25.8.2946-2956.2005  0.4
2005 Datta S, Osborne TF. Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers. The Journal of Biological Chemistry. 280: 3338-45. PMID 15550381 DOI: 10.1074/jbc.M411222200  1
2004 Mullen E, Brown RM, Osborne TF, Shay NF. Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells. The Journal of Nutrition. 134: 2942-7. PMID 15514256  0.4
2004 Toth JI, Datta S, Athanikar JN, Freedman LP, Osborne TF. Selective coactivator interactions in gene activation by SREBP-1a and -1c. Molecular and Cellular Biology. 24: 8288-300. PMID 15340088 DOI: 10.1128/MCB.24.18.8288-8300.2004  1
2004 Bennett MK, Toth JI, Osborne TF. Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo. The Journal of Biological Chemistry. 279: 37360-7. PMID 15220339 DOI: 10.1074/jbc.M404693200  0.52
2004 Worgall TS, Davis-Hayman SR, Magana MM, Oelkers PM, Zapata F, Juliano RA, Osborne TF, Nash TE, Deckelbaum RJ. Sterol and fatty acid regulatory pathways in a Giardia lamblia-derived promoter: evidence for SREBP as an ancient transcription factor. Journal of Lipid Research. 45: 981-8. PMID 14967824 DOI: 10.1194/jlr.M400024-JLR200  0.4
2002 Park HJ, Begley U, Kong D, Yu H, Yin L, Hillgartner FB, Osborne TF, Galper JB. Role of sterol regulatory element binding proteins in the regulation of Galpha(i2) expression in cultured atrial cells. Circulation Research. 91: 32-7. PMID 12114319 DOI: 10.1161/01.RES.0000026502.79063.66  0.4
2002 Ngo TT, Bennett MK, Bourgeois AL, Toth JI, Osborne TF. A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of the promoter for 3-hydroxy-3-methylglutaryl coenzyme A reductase. The Journal of Biological Chemistry. 277: 33901-5. PMID 12110665 DOI: 10.1074/jbc.M202135200  0.4
2002 Mallampalli RK, Ryan AJ, Carroll JL, Osborne TF, Thomas CP. Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter. The Biochemical Journal. 362: 81-8. PMID 11829742 DOI: 10.1042/0264-6021:3620081  0.4
2002 Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF, Tontonoz P. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. The Journal of Biological Chemistry. 277: 11019-25. PMID 11790787 DOI: 10.1074/jbc.M111041200  0.4
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