Charles Rudin - Publications

Affiliations: 
University of Chicago, Chicago, IL 
Area:
Molecular Biology

94 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Pietanza MC, Litvak AM, Varghese AM, Krug LM, Fleisher M, Teitcher JB, Holodny AI, Sima CS, Woo KM, Ng KK, Won HH, Berger MF, Kris MG, Rudin CM. A phase I trial of the Hedgehog inhibitor, sonidegib (LDE225), in combination with etoposide and cisplatin for the initial treatment of extensive stage small cell lung cancer. Lung Cancer (Amsterdam, Netherlands). 99: 23-30. PMID 27565909 DOI: 10.1016/j.lungcan.2016.04.014  0.72
2016 Shamay Y, Elkabets M, Li H, Shah J, Brook S, Wang F, Adler K, Baut E, Scaltriti M, Jena PV, Gardner EE, Poirier JT, Rudin CM, Baselga J, Haimovitz-Friedman A, et al. P-selectin is a nanotherapeutic delivery target in the tumor microenvironment. Science Translational Medicine. 8: 345ra87. PMID 27358497 DOI: 10.1126/scitranslmed.aaf7374  0.72
2016 Weiskopf K, Jahchan NS, Schnorr PJ, Cristea S, Ring AM, Maute RL, Volkmer AK, Volkmer JP, Liu J, Lim JS, Yang D, Seitz G, Nguyen T, Wu D, Jude K, ... ... Rudin CM, et al. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. The Journal of Clinical Investigation. PMID 27294525 DOI: 10.1172/JCI81603  0.72
2016 Belani CP, Dahlberg SE, Rudin CM, Fleisher M, Chen HX, Takebe N, Velasco MR, Tester WJ, Sturtz K, Hann CL, Shanks JC, Monga M, Ramalingam SS, Schiller JH. Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive-stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E1508). Cancer. PMID 27163943 DOI: 10.1002/cncr.30062  0.72
2016 Rekhtman N, Pietanza MC, Hellmann M, Naidoo J, Arora A, Won H, Halpenny DF, Wang H, Tian SK, Litvak AM, Paik PK, Drilon A, Socci N, Poirier JT, Shen R, ... ... Rudin CM, et al. Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26960398 DOI: 10.1158/1078-0432.CCR-15-2946  0.72
2016 Naidoo J, Santos-Zabala ML, Iyriboz T, Woo KM, Sima CS, Fiore JJ, Kris MG, Riely GJ, Lito P, Iqbal A, Veach S, Smith-Marrone S, Sarkaria IS, Krug LM, Rudin CM, et al. Large Cell Neuroendocrine Carcinoma of the Lung: Clinico-Pathologic Features, Treatment, and Outcomes. Clinical Lung Cancer. PMID 26898325 DOI: 10.1016/j.cllc.2016.01.003  0.72
2016 Bunn PA, Minna J, Augustyn A, Gazdar A, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier J, ... ... Rudin CM, et al. Small Cell Lung Cancer: Can recent advances in biology and molecular biology be translated into improved outcomes? Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 26829312 DOI: 10.1016/j.jtho.2016.01.012  0.72
2015 Zong H, Gozman A, Caldas-Lopes E, Taldone T, Sturgill E, Brennan S, Ochiana SO, Gomes-DaGama EM, Sen S, Rodina A, Koren J, Becker MW, Rudin CM, Melnick A, Levine RL, et al. A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species. Cell Reports. PMID 26628369 DOI: 10.1016/j.celrep.2015.10.073  0.72
2015 Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, Chow LQ, Vokes EE, Felip E, Holgado E, Barlesi F, Kohlhäufl M, Arrieta O, Burgio MA, Fayette J, ... ... Rudin CM, et al. Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. The New England Journal of Medicine. 373: 1627-39. PMID 26412456 DOI: 10.1056/NEJMoa1507643  0.72
2015 Saunders LR, Bankovich AJ, Anderson WC, Aujay MA, Bheddah S, Black K, Desai R, Escarpe PA, Hampl J, Laysang A, Liu D, Lopez-Molina J, Milton M, Park A, Pysz MA, ... ... Rudin CM, et al. A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. Science Translational Medicine. 7: 302ra136. PMID 26311731 DOI: 10.1126/scitranslmed.aac9459  0.72
2015 Ujiie H, Kadota K, Chaft JE, Buitrago D, Sima CS, Lee MC, Huang J, Travis WD, Rizk NP, Rudin CM, Jones DR, Adusumilli PS. Solid Predominant Histologic Subtype in Resected Stage I Lung Adenocarcinoma Is an Independent Predictor of Early, Extrathoracic, Multisite Recurrence and of Poor Postrecurrence Survival. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 26261257 DOI: 10.1200/JCO.2015.60.9818  0.72
2015 Miles LA, Brennen WN, Rudin CM, Poirier JT. Seneca Valley Virus 3Cpro Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy. Plos One. 10: e0129103. PMID 26069962 DOI: 10.1371/journal.pone.0129103  0.72
2015 Sekulic A, Migden MR, Lewis K, Hainsworth JD, Solomon JA, Yoo S, Arron ST, Friedlander PA, Marmur E, Rudin CM, Chang AL, Dirix L, Hou J, Yue H, Hauschild A, et al. Pivotal ERIVANCE basal cell carcinoma (BCC) study: 12-month update of efficacy and safety of vismodegib in advanced BCC. Journal of the American Academy of Dermatology. 72: 1021-6.e8. PMID 25981002 DOI: 10.1016/j.jaad.2015.03.021  0.72
2015 Pietanza MC, Byers LA, Minna JD, Rudin CM. Small cell lung cancer: will recent progress lead to improved outcomes? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2244-55. PMID 25979931 DOI: 10.1158/1078-0432.CCR-14-2958  0.72
2015 Paik PK, Drilon A, Fan PD, Yu H, Rekhtman N, Ginsberg MS, Borsu L, Schultz N, Berger MF, Rudin CM, Ladanyi M. Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. Cancer Discovery. PMID 25971939 DOI: 10.1158/2159-8290.CD-14-1467  0.72
2015 Chandra V, Das T, Gulati P, Biswas NK, Rote S, Chatterjee U, Ghosh SN, Deb S, Saha SK, Chowdhury AK, Ghosh S, Rudin CM, Mukherjee A, Basu A, Dhara S. Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters. Plos One. 10: e0116390. PMID 25775002 DOI: 10.1371/journal.pone.0116390  0.72
2015 Sharpe HJ, Pau G, Dijkgraaf GJ, Basset-Seguin N, Modrusan Z, Januario T, Tsui V, Durham AB, Dlugosz AA, Haverty PM, Bourgon R, Tang JY, Sarin KY, Dirix L, Fisher DC, ... Rudin CM, et al. Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma. Cancer Cell. 27: 327-41. PMID 25759019 DOI: 10.1016/j.ccell.2015.02.001  0.72
2015 Niederst MJ, Sequist LV, Poirier JT, Mermel CH, Lockerman EL, Garcia AR, Katayama R, Costa C, Ross KN, Moran T, Howe E, Fulton LE, Mulvey HE, Bernardo LA, Mohamoud F, ... ... Rudin CM, et al. RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Nature Communications. 6: 6377. PMID 25758528 DOI: 10.1038/ncomms7377  0.72
2015 Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, Pham L, Wang MM, Karachaliou N, Cao MG, Manzano JL, ... ... Rudin CM, et al. The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nature Genetics. 47: 250-6. PMID 25665005 DOI: 10.1038/ng.3218  0.72
2015 Jimeno A, Bauman JE, Weissman C, Adkins D, Schnadig I, Beauregard P, Bowles DW, Spira A, Levy B, Seetharamu N, Hausman D, Walker L, Rudin CM, Shirai K. A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic head and neck squamous cell cancer. Oral Oncology. 51: 383-8. PMID 25593016 DOI: 10.1016/j.oraloncology.2014.12.013  0.72
2015 Morgensztern D, Campo MJ, Dahlberg SE, Doebele RC, Garon E, Gerber DE, Goldberg SB, Hammerman PS, Heist RS, Hensing T, Horn L, Ramalingam SS, Rudin CM, Salgia R, Sequist LV, et al. Molecularly targeted therapies in non-small-cell lung cancer annual update 2014. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 10: S1-63. PMID 25535693 DOI: 10.1097/JTO.0000000000000405  0.72
2015 Vendetti FP, Topper M, Huang P, Dobromilskaya I, Easwaran H, Wrangle J, Baylin SB, Poirier JT, Rudin CM. Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer. Oncotarget. 6: 56-70. PMID 25474141  0.72
2015 Byers LA, Rudin CM. Small cell lung cancer: where do we go from here? Cancer. 121: 664-72. PMID 25336398 DOI: 10.1002/cncr.29098  0.72
2015 Burke MJ, Ahern C, Weigel BJ, Poirier JT, Rudin CM, Chen Y, Cripe TP, Bernhardt MB, Blaney SM. Phase I trial of Seneca Valley Virus (NTX-010) in children with relapsed/refractory solid tumors: a report of the Children's Oncology Group. Pediatric Blood & Cancer. 62: 743-50. PMID 25307519 DOI: 10.1002/pbc.25269  0.72
2015 Bai RY, Staedtke V, Rudin CM, Bunz F, Riggins GJ. Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis. Neuro-Oncology. 17: 545-54. PMID 25253417 DOI: 10.1093/neuonc/nou234  0.72
2014 Litvak AM, Paik PK, Woo KM, Sima CS, Hellmann MD, Arcila ME, Ladanyi M, Rudin CM, Kris MG, Riely GJ. Clinical characteristics and course of 63 patients with BRAF mutant lung cancers. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 1669-74. PMID 25436800 DOI: 10.1097/JTO.0000000000000344  0.72
2014 Drilon A, Sugita H, Sima CS, Zauderer M, Rudin CM, Kris MG, Rusch VW, Azzoli CG. A prospective study of tumor suppressor gene methylation as a prognostic biomarker in surgically resected stage I to IIIA non-small-cell lung cancers. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 1272-7. PMID 25122424 DOI: 10.1097/JTO.0000000000000256  0.72
2014 Rudin CM, Drilon A, Poirier JT. RET mutations in neuroendocrine tumors: including small-cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 1240-2. PMID 25122419 DOI: 10.1097/JTO.0000000000000301  0.72
2014 Levy B, Spira A, Becker D, Evans T, Schnadig I, Camidge DR, Bauman JE, Hausman D, Walker L, Nemunaitis J, Rudin CM, Halmos B, Bowles DW. A randomized, phase 2 trial of Docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic non-small-cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 1031-5. PMID 24926548 DOI: 10.1097/JTO.0000000000000183  0.72
2014 Kris MG, Johnson BE, Berry LD, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Varella-Garcia M, Franklin WA, Aronson SL, Su PF, Shyr Y, Camidge DR, Sequist LV, Glisson BS, Khuri FR, ... ... Rudin C, et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. Jama. 311: 1998-2006. PMID 24846037 DOI: 10.1001/jama.2014.3741  0.72
2014 Dogan I, Kawabata S, Bergbower E, Gills JJ, Ekmekci A, Wilson W, Rudin CM, Dennis PA. SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines. Lung Cancer (Amsterdam, Netherlands). 85: 1-6. PMID 24746758 DOI: 10.1016/j.lungcan.2014.03.021  0.72
2014 Gardner EE, Connis N, Poirier JT, Cope L, Dobromilskaya I, Gallia GL, Rudin CM, Hann CL. Rapamycin rescues ABT-737 efficacy in small cell lung cancer. Cancer Research. 74: 2846-56. PMID 24614082 DOI: 10.1158/0008-5472.CAN-13-3460  0.72
2014 Rudin CM, Poirier JT. MYC, MAX, and small cell lung cancer. Cancer Discovery. 4: 273-4. PMID 24596200 DOI: 10.1158/2159-8290.CD-14-0069  0.72
2014 Lin L, Asthana S, Chan E, Bandyopadhyay S, Martins MM, Olivas V, Yan JJ, Pham L, Wang MM, Bollag G, Solit DB, Collisson EA, Rudin CM, Taylor BS, Bivona TG. Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: E748-57. PMID 24550319 DOI: 10.1073/pnas.1320956111  0.72
2014 Forde PM, Hooker CM, Boikos SA, Petrini I, Giaccone G, Rudin CM, Yang SC, Illei PB, Hann CL, Ettinger DS, Brahmer JR, Kelly RJ. Systemic therapy, clinical outcomes, and overall survival in locally advanced or metastatic pulmonary carcinoid: a brief report. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 414-8. PMID 24518093 DOI: 10.1097/JTO.0000000000000065  0.72
2014 Kanarek NF, Hooker CM, Mathieu L, Tsai HL, Rudin CM, Herman JG, Brock MV. Survival after community diagnosis of early-stage non-small cell lung cancer. The American Journal of Medicine. 127: 443-9. PMID 24486286 DOI: 10.1016/j.amjmed.2013.12.023  0.72
2013 Wrangle J, Wang W, Koch A, Easwaran H, Mohammad HP, Vendetti F, Vancriekinge W, Demeyer T, Du Z, Parsana P, Rodgers K, Yen RW, Zahnow CA, Taube JM, Brahmer JR, ... ... Rudin CM, et al. Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine. Oncotarget. 4: 2067-79. PMID 24162015  0.72
2013 Gajula RP, Chettiar ST, Williams RD, Thiyagarajan S, Kato Y, Aziz K, Wang R, Gandhi N, Wild AT, Vesuna F, Ma J, Salih T, Cades J, Fertig E, Biswal S, ... ... Rudin CM, et al. The twist box domain is required for Twist1-induced prostate cancer metastasis. Molecular Cancer Research : McR. 11: 1387-400. PMID 23982216 DOI: 10.1158/1541-7786.MCR-13-0218-T  0.72
2013 Vendetti FP, Rudin CM. Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylases. Expert Opinion On Biological Therapy. 13: 1273-85. PMID 23859704 DOI: 10.1517/14712598.2013.819337  0.72
2013 Poirier JT, Dobromilskaya I, Moriarty WF, Peacock CD, Hann CL, Rudin CM. Selective tropism of Seneca Valley virus for variant subtype small cell lung cancer. Journal of the National Cancer Institute. 105: 1059-65. PMID 23739064 DOI: 10.1093/jnci/djt130  0.72
2013 Juergens RA, Rudin CM. Aberrant epigenetic regulation: a central contributor to lung carcinogenesis and a new therapeutic target. American Society of Clinical Oncology Educational Book / Asco. American Society of Clinical Oncology. Meeting. PMID 23714528 DOI: 10.1200/EdBook_AM.2013.33.e295  0.72
2013 Jimeno A, Weiss GJ, Miller WH, Gettinger S, Eigl BJ, Chang AL, Dunbar J, Devens S, Faia K, Skliris G, Kutok J, Lewis KD, Tibes R, Sharfman WH, Ross RW, ... Rudin CM, et al. Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2766-74. PMID 23575478 DOI: 10.1158/1078-0432.CCR-12-3654  0.72
2013 Azad N, Zahnow CA, Rudin CM, Baylin SB. The future of epigenetic therapy in solid tumours--lessons from the past. Nature Reviews. Clinical Oncology. 10: 256-66. PMID 23546521 DOI: 10.1038/nrclinonc.2013.42  0.72
2013 Rudin CM, Brahmer JR, Juergens RA, Hann CL, Ettinger DS, Sebree R, Smith R, Aftab BT, Huang P, Liu JO. Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 8: 619-23. PMID 23546045 DOI: 10.1097/JTO.0b013e31828c3950  0.72
2013 Rudin CM, Hong K, Streit M. Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 8: e41-2. PMID 23524406 DOI: 10.1097/JTO.0b013e31828bb1b3  0.72
2013 Zinn RL, Gardner EE, Marchionni L, Murphy SC, Dobromilskaya I, Hann CL, Rudin CM. ERK phosphorylation is predictive of resistance to IGF-1R inhibition in small cell lung cancer. Molecular Cancer Therapeutics. 12: 1131-9. PMID 23515613 DOI: 10.1158/1535-7163.MCT-12-0618  0.72
2013 Ohashi K, Sequist LV, Arcila ME, Lovly CM, Chen X, Rudin CM, Moran T, Camidge DR, Vnencak-Jones CL, Berry L, Pan Y, Sasaki H, Engelman JA, Garon EB, Dubinett SM, et al. Characteristics of lung cancers harboring NRAS mutations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2584-91. PMID 23515407 DOI: 10.1158/1078-0432.CCR-12-3173  0.72
2013 Zinn RL, Gardner EE, Dobromilskaya I, Murphy S, Marchionni L, Hann CL, Rudin CM. Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer. Molecular Cancer. 12: 16. PMID 23452820 DOI: 10.1186/1476-4598-12-16  0.72
2013 Kamat CD, Shmueli RB, Connis N, Rudin CM, Green JJ, Hann CL. Poly(β-amino ester) nanoparticle delivery of TP53 has activity against small cell lung cancer in vitro and in vivo. Molecular Cancer Therapeutics. 12: 405-15. PMID 23364678 DOI: 10.1158/1535-7163.MCT-12-0956  0.72
2013 Burns TF, Dobromilskaya I, Murphy SC, Gajula RP, Thiyagarajan S, Chatley SN, Aziz K, Cho YJ, Tran PT, Rudin CM. Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer. Molecular Cancer Research : McR. 11: 329-38. PMID 23364532 DOI: 10.1158/1541-7786.MCR-12-0456  0.72
2013 Kalemkerian GP, Akerley W, Bogner P, Borghaei H, Chow LQ, Downey RJ, Gandhi L, Ganti AK, Govindan R, Grecula JC, Hayman J, Heist RS, Horn L, Jahan T, Koczywas M, ... ... Rudin CM, et al. Small cell lung cancer. Journal of the National Comprehensive Cancer Network : Jnccn. 11: 78-98. PMID 23307984  0.72
2013 Kim J, Aftab BT, Tang JY, Kim D, Lee AH, Rezaee M, Kim J, Chen B, King EM, Borodovsky A, Riggins GJ, Epstein EH, Beachy PA, Rudin CM. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell. 23: 23-34. PMID 23291299 DOI: 10.1016/j.ccr.2012.11.017  0.72
2013 Zeng J, Aziz K, Chettiar ST, Aftab BT, Armour M, Gajula R, Gandhi N, Salih T, Herman JM, Wong J, Rudin CM, Tran PT, Hales RK. Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers. International Journal of Radiation Oncology, Biology, Physics. 86: 143-9. PMID 23182391 DOI: 10.1016/j.ijrobp.2012.10.014  0.72
2012 Poirier JT, Reddy PS, Idamakanti N, Li SS, Stump KL, Burroughs KD, Hallenbeck PL, Rudin CM. Characterization of a full-length infectious cDNA clone and a GFP reporter derivative of the oncolytic picornavirus SVV-001. The Journal of General Virology. 93: 2606-13. PMID 22971818 DOI: 10.1099/vir.0.046011-0  0.72
2012 Rudin CM, Durinck S, Stawiski EW, Poirier JT, Modrusan Z, Shames DS, Bergbower EA, Guan Y, Shin J, Guillory J, Rivers CS, Foo CK, Bhatt D, Stinson J, Gnad F, et al. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nature Genetics. 44: 1111-6. PMID 22941189 DOI: 10.1038/ng.2405  0.72
2012 Rudin CM. Vismodegib. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 3218-22. PMID 22679179 DOI: 10.1158/1078-0432.CCR-12-0568  0.72
2012 Sekulic A, Migden MR, Oro AE, Dirix L, Lewis KD, Hainsworth JD, Solomon JA, Yoo S, Arron ST, Friedlander PA, Marmur E, Rudin CM, Chang AL, Low JA, Mackey HM, et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. The New England Journal of Medicine. 366: 2171-9. PMID 22670903 DOI: 10.1056/NEJMoa1113713  0.72
2012 Tran PT, Shroff EH, Burns TF, Thiyagarajan S, Das ST, Zabuawala T, Chen J, Cho YJ, Luong R, Tamayo P, Salih T, Aziz K, Adam SJ, Vicent S, Nielsen CH, ... ... Rudin CM, et al. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. Plos Genetics. 8: e1002650. PMID 22654667 DOI: 10.1371/journal.pgen.1002650  0.72
2012 Forde PM, Rudin CM. Crizotinib in the treatment of non-small-cell lung cancer. Expert Opinion On Pharmacotherapy. 13: 1195-201. PMID 22594847 DOI: 10.1517/14656566.2012.688029  0.72
2012 Rudin CM, Hann CL, Garon EB, Ribeiro de Oliveira M, Bonomi PD, Camidge DR, Chu Q, Giaccone G, Khaira D, Ramalingam SS, Ranson MR, Dive C, McKeegan EM, Chyla BJ, Dowell BL, et al. Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 3163-9. PMID 22496272 DOI: 10.1158/1078-0432.CCR-11-3090  0.72
2012 Pietanza MC, Rudin CM. Novel therapeutic approaches for small cell lung cancer: the future has arrived. Current Problems in Cancer. 36: 156-73. PMID 22495056 DOI: 10.1016/j.currproblcancer.2012.03.005  0.72
2012 Pesch B, Kendzia B, Gustavsson P, Jöckel KH, Johnen G, Pohlabeln H, Olsson A, Ahrens W, Gross IM, Brüske I, Wichmann HE, Merletti F, Richiardi L, Simonato L, Fortes C, ... ... Rudin CM, et al. Cigarette smoking and lung cancer--relative risk estimates for the major histological types from a pooled analysis of case-control studies. International Journal of Cancer. Journal International Du Cancer. 131: 1210-9. PMID 22052329 DOI: 10.1002/ijc.27339  0.72
2012 Chenna V, Hu C, Pramanik D, Aftab BT, Karikari C, Campbell NR, Hong SM, Zhao M, Rudek MA, Khan SR, Rudin CM, Maitra A. A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists. Molecular Cancer Therapeutics. 11: 165-73. PMID 22027695 DOI: 10.1158/1535-7163.MCT-11-0341  0.72
2011 Juergens RA, Wrangle J, Vendetti FP, Murphy SC, Zhao M, Coleman B, Sebree R, Rodgers K, Hooker CM, Franco N, Lee B, Tsai S, Delgado IE, Rudek MA, Belinsky SA, ... ... Rudin CM, et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discovery. 1: 598-607. PMID 22586682 DOI: 10.1158/2159-8290.CD-11-0214  0.72
2011 Osanyingbemi-Obidi J, Dobromilskaya I, Illei PB, Hann CL, Rudin CM. Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo. Molecular Cancer Research : McR. 9: 1746-54. PMID 21994468 DOI: 10.1158/1541-7786.MCR-11-0286  0.72
2011 Kalemkerian GP, Akerley W, Bogner P, Borghaei H, Chow L, Downey RJ, Gandhi L, Ganti AK, Govindan R, Grecula JC, Hayman J, Heist RS, Horn L, Jahan TM, Koczywas M, ... ... Rudin CM, et al. Small cell lung cancer. Journal of the National Comprehensive Cancer Network : Jnccn. 9: 1086-113. PMID 21975911  0.72
2011 Shi W, Nacev BA, Aftab BT, Head S, Rudin CM, Liu JO. Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling. Journal of Medicinal Chemistry. 54: 7363-74. PMID 21936514 DOI: 10.1021/jm200944b  0.72
2011 Baggstrom MQ, Qi Y, Koczywas M, Argiris A, Johnson EA, Millward MJ, Murphy SC, Erlichman C, Rudin CM, Govindan R. A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 6: 1757-60. PMID 21918390 DOI: 10.1097/JTO.0b013e31822e2941  0.72
2011 Aftab BT, Dobromilskaya I, Liu JO, Rudin CM. Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer. Cancer Research. 71: 6764-72. PMID 21896639 DOI: 10.1158/0008-5472.CAN-11-0691  0.72
2011 Husain H, Rudin CM. ALK-targeted therapy for lung cancer: ready for prime time. Oncology (Williston Park, N.Y.). 25: 597-601. PMID 21888258  0.72
2011 Zhang YA, Maitra A, Hsieh JT, Rudin CM, Peacock CD, Karikari C, Brekken RA, Stastny V, Gao B, Girard L, Wistuba I, Frenkel E, Minna JD, Gazdar AF. Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts. Cancer Biology & Therapy. 12: 617-28. PMID 21750403 DOI: 10.4161/cbt.12.7.15955  0.72
2011 Paik PK, Rudin CM, Pietanza MC, Brown A, Rizvi NA, Takebe N, Travis W, James L, Ginsberg MS, Juergens R, Markus S, Tyson L, Subzwari S, Kris MG, Krug LM. A phase II study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in relapsed small cell lung cancer. Lung Cancer (Amsterdam, Netherlands). 74: 481-5. PMID 21620511 DOI: 10.1016/j.lungcan.2011.05.005  0.72
2011 Rudin CM, Poirier JT, Senzer NN, Stephenson J, Loesch D, Burroughs KD, Reddy PS, Hann CL, Hallenbeck PL. Phase I clinical study of Seneca Valley Virus (SVV-001), a replication-competent picornavirus, in advanced solid tumors with neuroendocrine features. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 888-95. PMID 21304001 DOI: 10.1158/1078-0432.CCR-10-1706  0.72
2011 Rudin CM, Mauer A, Smakal M, Juergens R, Spelda S, Wertheim M, Coates A, McKeegan E, Ansell P, Zhou X, Qian J, Pradhan R, Dowell B, Krivoshik A, Gordon G. Phase I/II study of pemetrexed with or without ABT-751 in advanced or metastatic non-small-cell lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 1075-82. PMID 21300929 DOI: 10.1200/JCO.2010.32.5944  0.72
2011 LoRusso PM, Rudin CM, Reddy JC, Tibes R, Weiss GJ, Borad MJ, Hann CL, Brahmer JR, Chang I, Darbonne WC, Graham RA, Zerivitz KL, Low JA, Von Hoff DD. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2502-11. PMID 21300762 DOI: 10.1158/1078-0432.CCR-10-2745  0.72
2011 Graham RA, Lum BL, Cheeti S, Jin JY, Jorga K, Von Hoff DD, Rudin CM, Reddy JC, Low JA, Lorusso PM. Pharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: the role of alpha-1-acid glycoprotein binding. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2512-20. PMID 21300760 DOI: 10.1158/1078-0432.CCR-10-2736  0.72
2011 Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, ... ... Rudin CM, et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 471: 325-30. PMID 21297615 DOI: 10.1038/nature09830  0.72
2011 Gandhi L, Camidge DR, Ribeiro de Oliveira M, Bonomi P, Gandara D, Khaira D, Hann CL, McKeegan EM, Litvinovich E, Hemken PM, Dive C, Enschede SH, Nolan C, Chiu YL, Busman T, ... ... Rudin CM, et al. Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 909-16. PMID 21282543 DOI: 10.1200/JCO.2010.31.6208  0.72
2010 Klamerus JF, Bruinooge SS, Ye X, Klamerus ML, Damron D, Lansey D, Lowery JC, Diaz LA, Ford JG, Kanarek N, Rudin CM. The impact of insurance on access to cancer clinical trials at a comprehensive cancer center. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 5997-6003. PMID 21169253 DOI: 10.1158/1078-0432.CCR-10-1451  0.72
2010 Kanarek NF, Tsai HL, Metzger-Gaud S, Damron D, Guseynova A, Klamerus JF, Rudin CM. Geographic proximity and racial disparities in cancer clinical trial participation. Journal of the National Comprehensive Cancer Network : Jnccn. 8: 1343-51. PMID 21147901  0.72
2010 Peacock CD, Rudin CM. Skin deep and deeper: multiple pathways in basal cell carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.). 3: 1213-6. PMID 20858762 DOI: 10.1158/1940-6207.CAPR-10-0203  0.72
2009 Rudin CM, Avila-Tang E, Harris CC, Herman JG, Hirsch FR, Pao W, Schwartz AG, Vahakangas KH, Samet JM. Lung cancer in never smokers: molecular profiles and therapeutic implications. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 5646-61. PMID 19755392 DOI: 10.1158/1078-0432.CCR-09-0377  0.72
2009 Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, Bazan JF, Kan Z, Seshagiri S, Hann CL, Gould SE, ... ... Rudin CM, et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science (New York, N.Y.). 326: 572-4. PMID 19726788 DOI: 10.1126/science.1179386  0.72
2009 Von Hoff DD, LoRusso PM, Rudin CM, Reddy JC, Yauch RL, Tibes R, Weiss GJ, Borad MJ, Hann CL, Brahmer JR, Mackey HM, Lum BL, Darbonne WC, Marsters JC, de Sauvage FJ, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. The New England Journal of Medicine. 361: 1164-72. PMID 19726763 DOI: 10.1056/NEJMoa0905360  0.72
2009 Hulleman E, Kazemier KM, Holleman A, VanderWeele DJ, Rudin CM, Broekhuis MJ, Evans WE, Pieters R, Den Boer ML. Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells. Blood. 113: 2014-21. PMID 18978206 DOI: 10.1182/blood-2008-05-157842  0.72
2007 Hagan CR, Rudin CM. DNA cleavage and Trp53 differentially affect SINE transcription. Genes, Chromosomes & Cancer. 46: 248-60. PMID 17171681 DOI: 10.1002/gcc.20406  0.88
2007 Brace JL, Lester RL, Dickson RC, Rudin CM. SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae. Genetics. 175: 65-76. PMID 17057230 DOI: 10.1534/genetics.106.064527  1
2005 Vanderweele DJ, Rudin CM. Mammalian target of rapamycin promotes vincristine resistance through multiple mechanisms independent of maintained glycolytic rate. Molecular Cancer Research : McR. 3: 635-44. PMID 16317089 DOI: 10.1158/1541-7786.MCR-05-0063  1
2005 Brace JL, Vanderweele DJ, Rudin CM. Svf1 inhibits reactive oxygen species generation and promotes survival under conditions of oxidative stress in Saccharomyces cerevisiae. Yeast (Chichester, England). 22: 641-52. PMID 16034825 DOI: 10.1002/yea.1235  1
2004 VanderWeele DJ, Zhou R, Rudin CM. Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin. Molecular Cancer Therapeutics. 3: 1605-13. PMID 15634654  1
2003 Hagan CR, Sheffield RF, Rudin CM. Human Alu element retrotransposition induced by genotoxic stress. Nature Genetics. 35: 219-20. PMID 14578886 DOI: 10.1038/ng1259  0.72
2003 Rudin CM, Yang Z, Schumaker LM, VanderWeele DJ, Newkirk K, Egorin MJ, Zuhowski EG, Cullen KJ. Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance. Cancer Research. 63: 312-8. PMID 12543781  0.72
2002 Vander Heiden MG, Choy JS, VanderWeele DJ, Brace JL, Harris MH, Bauer DE, Prange B, Kron SJ, Thompson CB, Rudin CM. Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. The Journal of Biological Chemistry. 277: 44870-6. PMID 12244097 DOI: 10.1074/jbc.M204888200  0.72
2002 Hagan CR, Rudin CM. Mobile genetic element activation and genotoxic cancer therapy: potential clinical implications. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 2: 25-35. PMID 12083952  0.88
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