Kathryn Horwitz - Publications

Affiliations: 
University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Molecular Biology

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Abdel-Hafiz HA, Dudevoir ML, Perez D, Abdel-Hafiz M, Horwitz KB. SUMOylation Regulates Transcription by the Progesterone Receptor A Isoform in a Target Gene Selective Manner. Diseases (Basel, Switzerland). 6. PMID 29301281 DOI: 10.3390/diseases6010005  0.36
2014 Ogba N, Manning NG, Bliesner BS, Ambler SK, Haughian JM, Pinto MP, Jedlicka P, Joensuu K, Heikkilä P, Horwitz KB. Luminal breast cancer metastases and tumor arousal from dormancy are promoted by direct actions of estradiol and progesterone on the malignant cells. Breast Cancer Research : Bcr. 16: 489. PMID 25475897 DOI: 10.1186/s13058-014-0489-4  0.32
2014 Pinto MP, Dye WW, Jacobsen BM, Horwitz KB. Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling. Bmc Cancer. 14: 735. PMID 25274034 DOI: 10.1186/1471-2407-14-735  0.44
2014 Knox AJ, Scaling AL, Pinto MP, Bliesner BS, Haughian JM, Abdel-Hafiz HA, Horwitz KB. Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal disease. Breast Cancer Research : Bcr. 16: 418. PMID 25116921 DOI: 10.1186/s13058-014-0418-6  0.36
2013 Harvell DM, Kim J, O'Brien J, Tan AC, Borges VF, Schedin P, Jacobsen BM, Horwitz KB. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Hormones & Cancer. 4: 140-53. PMID 23479404 DOI: 10.1007/s12672-013-0136-z  0.32
2013 Jambal P, Badtke MM, Harrell JC, Borges VF, Post MD, Sollender GE, Spillman MA, Horwitz KB, Jacobsen BM. Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features. Breast Cancer Research and Treatment. 137: 431-48. PMID 23247610 DOI: 10.1007/s10549-012-2377-x  0.44
2012 Haughian JM, Pinto MP, Harrell JC, Bliesner BS, Joensuu KM, Dye WW, Sartorius CA, Tan AC, Heikkilä P, Perou CM, Horwitz KB. Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch. Proceedings of the National Academy of Sciences of the United States of America. 109: 2742-7. PMID 21969591 DOI: 10.1073/pnas.1106509108  0.32
2012 Jacobsen BM, Horwitz KB. Progesterone receptors, their isoforms and progesterone regulated transcription. Molecular and Cellular Endocrinology. 357: 18-29. PMID 21952082 DOI: 10.1016/j.mce.2011.09.016  0.44
2012 Badtke MM, Jambal P, Dye WW, Spillman MA, Post MD, Horwitz KB, Jacobsen BM. Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpoint. Breast Cancer Research and Treatment. 131: 75-87. PMID 21340479 DOI: 10.1007/s10549-011-1399-0  0.44
2011 Pinto MP, Jacobsen BM, Horwitz KB. An immunohistochemical method to study breast cancer cell subpopulations and their growth regulation by hormones in three-dimensional cultures. Frontiers in Endocrinology. 2: 15. PMID 22649363 DOI: 10.3389/fendo.2011.00015  0.44
2011 Kabos P, Haughian JM, Wang X, Dye WW, Finlayson C, Elias A, Horwitz KB, Sartorius CA. Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopulation in luminal breast cancers. Breast Cancer Research and Treatment. 128: 45-55. PMID 20665103 DOI: 10.1007/s10549-010-1078-6  0.32
2010 Spillman MA, Manning NG, Dye WW, Sartorius CA, Post MD, Harrell JC, Jacobsen BM, Horwitz KB. Tissue-specific pathways for estrogen regulation of ovarian cancer growth and metastasis. Cancer Research. 70: 8927-36. PMID 20959477 DOI: 10.1158/0008-5472.CAN-10-1238  0.44
2010 Pinto MP, Badtke MM, Dudevoir ML, Harrell JC, Jacobsen BM, Horwitz KB. Vascular endothelial growth factor secreted by activated stroma enhances angiogenesis and hormone-independent growth of estrogen receptor-positive breast cancer. Cancer Research. 70: 2655-64. PMID 20332242 DOI: 10.1158/0008-5472.CAN-09-4373  0.44
2009 Micalizzi DS, Christensen KL, Jedlicka P, Coletta RD, Barón AE, Harrell JC, Horwitz KB, Billheimer D, Heichman KA, Welm AL, Schiemann WP, Ford HL. The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. The Journal of Clinical Investigation. 119: 2678-90. PMID 19726885 DOI: 10.1172/JCI37815  0.32
2009 Jacobsen BM, Jambal P, Schittone SA, Horwitz KB. ALU repeats in promoters are position-dependent co-response elements (coRE) that enhance or repress transcription by dimeric and monomeric progesterone receptors. Molecular Endocrinology (Baltimore, Md.). 23: 989-1000. PMID 19372234 DOI: 10.1210/me.2009-0048  0.32
2009 Abdel-Hafiz H, Dudevoir ML, Horwitz KB. Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation. The Journal of Biological Chemistry. 284: 9099-108. PMID 19211567 DOI: 10.1074/jbc.M805226200  0.36
2008 Lange CA, Sartorius CA, Abdel-Hafiz H, Spillman MA, Horwitz KB, Jacobsen BM. Progesterone receptor action: translating studies in breast cancer models to clinical insights. Advances in Experimental Medicine and Biology. 630: 94-111. PMID 18637487  0.44
2008 Singh M, Spoelstra NS, Jean A, Howe E, Torkko KC, Clark HR, Darling DS, Shroyer KR, Horwitz KB, Broaddus RR, Richer JK. ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive disease. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 21: 912-23. PMID 18487993 DOI: 10.1038/modpathol.2008.82  0.32
2008 Horwitz KB, Dye WW, Harrell JC, Kabos P, Sartorius CA. Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Proceedings of the National Academy of Sciences of the United States of America. 105: 5774-9. PMID 18391223 DOI: 10.1073/pnas.0706216105  0.32
2008 Harvell DM, Richer JK, Singh M, Spoelstra N, Finlayson C, Borges VF, Elias AD, Horwitz KB. Estrogen regulated gene expression in response to neoadjuvant endocrine therapy of breast cancers: tamoxifen agonist effects dominate in the presence of an aromatase inhibitor. Breast Cancer Research and Treatment. 112: 489-501. PMID 18338247 DOI: 10.1007/s10549-008-9923-6  0.32
2008 Harvell DM, Spoelstra NS, Singh M, McManaman JL, Finlayson C, Phang T, Trapp S, Hunter L, Dye WW, Borges VF, Elias A, Horwitz KB, Richer JK. Molecular signatures of neoadjuvant endocrine therapy for breast cancer: characteristics of response or intrinsic resistance. Breast Cancer Research and Treatment. 112: 475-88. PMID 18327671 DOI: 10.1007/s10549-008-9897-4  0.32
2008 Harrell JC, Dye WW, Harvell DM, Sartorius CA, Horwitz KB. Contaminating cells alter gene signatures in whole organ versus laser capture microdissected tumors: a comparison of experimental breast cancers and their lymph node metastases. Clinical & Experimental Metastasis. 25: 81-8. PMID 17932773 DOI: 10.1007/s10585-007-9105-7  0.44
2007 Harrell JC, Dye WW, Harvell DM, Pinto M, Jedlicka P, Sartorius CA, Horwitz KB. Estrogen insensitivity in a model of estrogen receptor positive breast cancer lymph node metastasis. Cancer Research. 67: 10582-91. PMID 17975003 DOI: 10.1158/0008-5472.CAN-07-1655  0.32
2006 Harrell JC, Dye WW, Allred DC, Jedlicka P, Spoelstra NS, Sartorius CA, Horwitz KB. Estrogen receptor positive breast cancer metastasis: altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes. Cancer Research. 66: 9308-15. PMID 16982776 DOI: 10.1158/0008-5472.CAN-06-1769  0.32
2006 Jacobsen BM, Harrell JC, Jedlicka P, Borges VF, Varella-Garcia M, Horwitz KB. Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium. Cancer Research. 66: 8274-9. PMID 16912208 DOI: 10.1158/0008-5472.CAN-06-1456  0.32
2006 Tung L, Abdel-Hafiz H, Shen T, Harvell DM, Nitao LK, Richer JK, Sartorius CA, Takimoto GS, Horwitz KB. Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B. Molecular Endocrinology (Baltimore, Md.). 20: 2656-70. PMID 16762974 DOI: 10.1210/me.2006-0105  0.32
2006 Chadli A, Graham JD, Abel MG, Jackson TA, Gordon DF, Wood WM, Felts SJ, Horwitz KB, Toft D. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Molecular and Cellular Biology. 26: 1722-30. PMID 16478993 DOI: 10.1128/MCB.26.5.1722-1730.2006  0.32
2005 Ghatge RP, Jacobsen BM, Schittone SA, Horwitz KB. The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells. Breast Cancer Research : Bcr. 7: R1036-50. PMID 16457685 DOI: 10.1186/bcr1340  0.32
2005 Bray JD, Jelinsky S, Ghatge R, Bray JA, Tunkey C, Saraf K, Jacobsen BM, Richer JK, Brown EL, Winneker RC, Horwitz KB, Lyttle CR. Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 97: 328-41. PMID 16157482 DOI: 10.1016/j.jsbmb.2005.06.032  0.32
2005 Jacobsen BM, Schittone SA, Richer JK, Horwitz KB. Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biology. Molecular Endocrinology (Baltimore, Md.). 19: 574-87. PMID 15563544 DOI: 10.1210/me.2004-0287  0.32
2004 Hopp TA, Weiss HL, Hilsenbeck SG, Cui Y, Allred DC, Horwitz KB, Fuqua SA. Breast cancer patients with progesterone receptor PR-A-rich tumors have poorer disease-free survival rates. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 2751-60. PMID 15102680 DOI: 10.1158/1078-0432.CCR-03-0141  0.32
2003 Jacobsen BM, Richer JK, Sartorius CA, Horwitz KB. Expression profiling of human breast cancers and gene regulation by progesterone receptors. Journal of Mammary Gland Biology and Neoplasia. 8: 257-68. PMID 14973372  0.44
2003 Takimoto GS, Tung L, Abdel-Hafiz H, Abel MG, Sartorius CA, Richer JK, Jacobsen BM, Bain DL, Horwitz KB. Functional properties of the N-terminal region of progesterone receptors and their mechanistic relationship to structure. The Journal of Steroid Biochemistry and Molecular Biology. 85: 209-19. PMID 12943706 DOI: 10.1016/S0960-0760(03)00197-3  0.32
2002 Abdel-Hafiz H, Takimoto GS, Tung L, Horwitz KB. The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepression. The Journal of Biological Chemistry. 277: 33950-6. PMID 12114521 DOI: 10.1074/jbc.M204573200  0.32
2002 Jacobsen BM, Richer JK, Schittone SA, Horwitz KB. New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulation. The Journal of Biological Chemistry. 277: 27793-800. PMID 12021276 DOI: 10.1074/jbc.M202584200  0.32
2002 Richer JK, Jacobsen BM, Manning NG, Abel MG, Wolf DM, Horwitz KB. Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. The Journal of Biological Chemistry. 277: 5209-18. PMID 11717311 DOI: 10.1074/jbc.M110090200  0.44
2001 Pahl PMB, Horwitz MA, Horwitz KB, Horwitz LD. Desferri-exochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells Breast Cancer Research and Treatment. 69: 69-79. PMID 11759830 DOI: 10.1023/A:1012211828319  0.32
2001 Tung L, Shen T, Abel MG, Powell RL, Takimoto GS, Sartorius CA, Horwitz KB. Mapping the unique activation function 3 in the progesterone B-receptor upstream segment. Two LXXLL motifs and a tryptophan residue are required for activity. The Journal of Biological Chemistry. 276: 39843-51. PMID 11546784 DOI: 10.1074/jbc.M106843200  0.32
2001 Bain DL, Franden MA, McManaman JL, Takimoto GS, Horwitz KB. The N-terminal region of human progesterone B-receptors: biophysical and biochemical comparison to A-receptors. The Journal of Biological Chemistry. 276: 23825-31. PMID 11328821 DOI: 10.1074/jbc.M102611200  0.32
2000 Sartorius CA, Takimoto GS, Richer JK, Tung L, Horwitz KB. Association of the Ku autoantigen/DNA-dependent protein kinase holoenzyme and poly(ADP-ribose) polymerase with the DNA binding domain of progesterone receptors. Journal of Molecular Endocrinology. 24: 165-82. PMID 10750018 DOI: 10.1677/JME.0.0240165  0.32
2000 Bain DL, Franden MA, McManaman JL, Takimoto GS, Horwitz KB. The N-terminal region of the human progesterone A-receptor. Structural analysis and the influence of the DNA binding domain. The Journal of Biological Chemistry. 275: 7313-20. PMID 10702302 DOI: 10.1074/jbc.275.10.7313  0.32
1999 Takimoto GS, Graham JD, Jackson TA, Tung L, Powell RL, Horwitz LD, Horwitz KB. Tamoxifen resistant breast cancer: coregulators determine the direction of transcription by antagonist-occupied steroid receptors. The Journal of Steroid Biochemistry and Molecular Biology. 69: 45-50. PMID 10418980 DOI: 10.1016/S0960-0760(98)00148-4  0.32
1998 Richer JK, Lange CA, Wierman AM, Brooks KM, Tung L, Takimoto GS, Horwitz KB. Progesterone receptor variants found in breast cells repress transcription by wild-type receptors. Breast Cancer Research and Treatment. 48: 231-41. PMID 9598870 DOI: 10.1023/A:1005941117247  0.32
1998 Owen GI, Richer JK, Tung L, Takimoto G, Horwitz KB. Progesterone regulates transcription of the p21(WAF1) cyclin- dependent kinase inhibitor gene through Sp1 and CBP/p300. The Journal of Biological Chemistry. 273: 10696-701. PMID 9553133 DOI: 10.1074/jbc.273.17.10696  0.32
1998 Hovland AR, Powell RL, Takimoto GS, Tung L, Horwitz KB. An N-terminal inhibitory function, IF, suppresses transcription by the A-isoform but not the B-isoform of human progesterone receptors. The Journal of Biological Chemistry. 273: 5455-60. PMID 9488667 DOI: 10.1074/jbc.273.10.5455  0.32
1997 Leslie KK, Kumar NS, Richer J, Owen G, Takimoto G, Horwitz KB, Lange C. Differential expression of the A and B isoforms of progesterone receptor in human endometrial cancer cells. Only progesterone receptor B is induced by estrogen and associated with strong transcriptional activation. Annals of the New York Academy of Sciences. 828: 17-26. PMID 9329820 DOI: 10.1111/j.1749-6632.1997.tb48520.x  0.32
1997 Groshong SD, Owen GI, Grimison B, Schauer IE, Todd MC, Langan TA, Sclafani RA, Lange CA, Horwitz KB. Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1). Molecular Endocrinology (Baltimore, Md.). 11: 1593-607. PMID 9328342 DOI: 10.1210/mend.11.11.0006  0.32
1997 Petz LN, Nardulli AM, Kim J, Horwitz KB, Freedman LP, Shapiro DJ. DNA bending is induced by binding of the glucocorticoid receptor DNA binding domain and progesterone receptors to their response element. The Journal of Steroid Biochemistry and Molecular Biology. 60: 31-41. PMID 9182856 DOI: 10.1016/S0960-0760(96)00171-9  0.32
1997 Jackson TA, Richer JK, Bain DL, Takimoto GS, Tung L, Horwitz KB. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT. Molecular Endocrinology (Baltimore, Md.). 11: 693-705. PMID 9171233 DOI: 10.1210/mend.11.6.0004  0.32
1996 Takimoto GS, Hovland AR, Tasset DM, Melville MY, Tung L, Horwitz KB. Role of phosphorylation on DNA binding and transcriptional functions of human progesterone receptors. The Journal of Biological Chemistry. 271: 13308-16. PMID 8662865 DOI: 10.1074/jbc.271.23.13308  0.32
1994 Crowley ST, Dempsey EC, Horwitz KB, Horwitz LD. Platelet-induced vascular smooth muscle cell proliferation is modulated by the growth amplification factors serotonin and adenosine diphosphate Circulation. 90: 1908-1918. PMID 7923679 DOI: 10.1161/01.CIR.90.4.1908  0.32
1994 Sartorius CA, Melville MY, Hovland AR, Tung L, Takimoto GS, Horwitz KB. A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform. Molecular Endocrinology (Baltimore, Md.). 8: 1347-60. PMID 7854352 DOI: 10.1210/mend.8.10.7854352  0.32
1994 Mohamed MK, Tung L, Takimoto GS, Horwitz KB. The leucine zippers of c-fos and c-jun for progesterone receptor dimerization: A-dominance in the A/B heterodimer. The Journal of Steroid Biochemistry and Molecular Biology. 51: 241-50. PMID 7826885 DOI: 10.1016/0960-0760(94)90036-1  0.32
1993 Takimoto GS, Horwitz KB. Progesterone receptor phosphorylation complexities in defining a functional role. Trends in Endocrinology and Metabolism: Tem. 4: 1-7. PMID 18407126 DOI: 10.1016/1043-2760(93)90056-K  0.32
1992 Takimoto GS, Tasset DM, Eppert AC, Horwitz KB. Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299. Proceedings of the National Academy of Sciences of the United States of America. 89: 3050-4. PMID 1557412 DOI: 10.1073/pnas.89.7.3050  0.32
1991 Takimoto GS, Tasset DM, Miller LA, Horwitz KB. Epitope mapping of the anti-human progesterone receptor monoclonal antibody, AB-52. The Journal of Steroid Biochemistry and Molecular Biology. 39: 687-92. PMID 1720326 DOI: 10.1016/0960-0760(91)90368-F  0.32
1987 Estes PA, Suba EJ, Lawler-Heavner J, Elashry-Stowers D, Wei LL, Toft DO, Sullivan WP, Horwitz KB, Edwards DP. Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies. Biochemistry. 26: 6250-62. PMID 3689773 DOI: 10.1021/bi00393a045  0.32
1986 Horwitz KB, Pike AW, Gonzalez-Aller C, Fennessey PV. Progesterone metabolism in T47Dco human breast cancer cells--II. Intracellular metabolic path of progesterone and synthetic progestins. Journal of Steroid Biochemistry. 25: 911-6. PMID 3467141 DOI: 10.1016/0022-4731(86)90323-7  0.32
1980 Edwards DP, Martin PM, Horwitz KB, Chamness GC, McGuire WL. Subcellular compartmentalization of estrogen receptors in human breast cancer cells. Experimental Cell Research. 127: 197-213. PMID 7379864 DOI: 10.1016/0014-4827(80)90427-9  0.32
1979 Zava DT, Landrum B, Horwitz KB, McGuire WL. Androgen receptor assay with [3H]methyltrienolone (R1881) in the presence of progesterone receptors. Endocrinology. 104: 1007-12. PMID 436741 DOI: 10.1210/endo-104-4-1007  0.32
1976 McGuire WL, Horwitz KB, De La Garza M. Selecting endocrine therapy in breast cancer Current Topics in Molecular Endocrinology. 4: 28-35. PMID 1027543 DOI: 10.1007/978-1-4684-2601-4_3  0.32
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