Christopher M. Overall - Publications

University of British Columbia, Vancouver, Vancouver, BC, Canada 
Molecular Biology

226 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Coates-Park S, Lazaroff C, Gurung S, Rich J, Colladay A, O'Neill M, Butler GS, Overall CM, Stetler-Stevenson WG, Peeney D. Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9. Matrix Biology : Journal of the International Society For Matrix Biology. 123: 59-70. PMID 37804930 DOI: 10.1016/j.matbio.2023.09.002  0.442
2022 Haack AM, Overall CM, Keller UAD. Degradomics technologies in matrisome exploration. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 36280126 DOI: 10.1016/j.matbio.2022.10.003  0.317
2020 Omenn GS, Lane L, Overall CM, Cristea IM, Corrales FJ, Lindskog C, Paik YK, Van Eyk JE, Liu S, Pennington S, Snyder MP, Baker MS, Bandeira N, Aebersold R, Moritz RL, et al. Research on The Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, according to the HUPO Human Proteome Project. Journal of Proteome Research. PMID 32931287 DOI: 10.1021/Acs.Jproteome.0C00485  0.344
2020 Falkowski K, Bielecka E, Thøgersen IB, Bocheńska O, Płaza K, Kalińska M, Sąsiadek L, Magoch M, Pęcak A, Wiśniewska M, Gruba N, Wysocka M, Wojtysiak A, Brzezińska-Bodal M, Sychowska K, ... ... Overall CM, et al. Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis. International Journal of Molecular Sciences. 21. PMID 32575583 DOI: 10.3390/Ijms21124383  0.523
2019 Fallata AM, Wyatt RA, Levesque JM, Dufour A, Overall CM, Crawford BD. Intracellular Localization in Zebrafish Muscle and Conserved Sequence Features Suggest Roles for Gelatinase A Moonlighting in Sarcomere Maintenance. Biomedicines. 7. PMID 31795436 DOI: 10.3390/Biomedicines7040093  0.425
2019 Jobin PG, Solis N, Machado Y, Bell PA, Rai SK, Kwon NH, Kim S, Overall CM, Butler GS. Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage. The Journal of Biological Chemistry. PMID 31771979 DOI: 10.1074/Jbc.Ra119.010486  0.516
2019 Bell PA, Solis N, Kizhakkedathu J, Matthew I, Overall CM. Proteomic and N-terminomic TAILS analyses of human alveolar bone proteins: Improved protein extraction methodology and LysargiNase digestion strategies increase proteome coverage and missing protein identification. Journal of Proteome Research. PMID 31601107 DOI: 10.1021/Acs.Jproteome.9B00445  0.373
2019 Omenn GS, Lane L, Overall CM, Corrales FJ, Schwenk JM, Paik YK, Van Eyk JE, Liu S, Pennington S, Snyder MP, Baker MS, Deutsch EW. Progress on Identifying and Characterizing the Human Proteome: 2018-2019 Metrics from the HUPO Human Proteome Project. Journal of Proteome Research. PMID 31430157 DOI: 10.1021/Acs.Jproteome.9B00434  0.347
2019 Zelanis A, Oliveira AK, Prudova A, Huesgen PF, Tashima AK, Kizhakkedathu J, Overall CM, de Toledo Serrano SM. Deep profiling of the cleavage specificity and human substrates of snake venom metalloprotease HF3 by PICS using proteome derived peptide libraries and TAILS N-terminomics. Journal of Proteome Research. PMID 31337208 DOI: 10.1021/Acs.Jproteome.9B00325  0.467
2019 Jobin PG, Solis N, Machado Y, Bell PA, Kwon NH, Kim S, Overall CM, Butler GS. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase. The Journal of Biological Chemistry. PMID 31324718 DOI: 10.1074/Jbc.Ra119.009584  0.506
2019 Lee J, Vinh N, Drinkwater N, Yang W, Kannan Sivaraman K, Schembri LS, Gazdik M, Grin P, Butler G, Overall CM, Charman SA, McGowan S, Scammells PJ. Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions. Journal of Medicinal Chemistry. PMID 31251594 DOI: 10.1021/Acs.Jmedchem.9B00757  0.342
2019 Chopra S, Overall CM, Dufour A. Matrix metalloproteinases in the CNS: interferons get nervous. Cellular and Molecular Life Sciences : Cmls. PMID 31165203 DOI: 10.1007/S00018-019-03171-9  0.5
2019 Ehrhardt K, Steck N, Kappelhoff R, Stein S, Rieder F, Gordon IO, Boyle EC, Braubach P, Overall CM, Finlay BB, Grassl GA. Persistent Salmonella enterica Serovar Typhimurium Infection Induces Protease Expression During Intestinal Fibrosis. Inflammatory Bowel Diseases. PMID 31066456 DOI: 10.1093/Ibd/Izz070  0.334
2019 Quancard J, Klein T, Fung SY, Renatus M, Hughes N, Israël L, Priatel JJ, Kang S, Blank MA, Viner RI, Blank J, Schlapbach A, Erbel P, Kizhakkedathu J, Villard F, ... ... Overall CM, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nature Chemical Biology. PMID 30692685 DOI: 10.1038/S41589-018-0222-1  0.37
2018 Paik YK, Overall CM, Corrales F, Deutsch EW, Lane L, Omenn GS. Toward Completion of the Human Proteome Parts List: Progress Uncovering Proteins That Are Missing or Have Unknown Function and Developing Analytical Methods. Journal of Proteome Research. 17: 4023-4030. PMID 30985145 DOI: 10.1021/Acs.Jproteome.8B00885  0.312
2018 Marshall NC, Klein T, Thejoe M, von Krosigk N, Kizhakkedathu J, Finlay BB, Overall CM. Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation. Journal of Proteome Research. PMID 30371095 DOI: 10.1021/Acs.Jproteome.8B00675  0.304
2018 Mallia-Milanes B, Dufour A, Philp C, Solis N, Klein T, Fischer M, Bolton CE, Shapiro SD, Overall CM, Johnson SR. TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30284925 DOI: 10.1152/Ajplung.00175.2018  0.426
2018 Paik YK, Lane L, Kawamura T, Chen YJ, Cho JY, LaBaer J, Yoo JS, Domont GB, Corrales F, Omenn GS, Archakov A, Encarnación-Guevara S, Liu S, Salekdeh GH, Cho JY, ... ... Overall CM, et al. Launching the C-HPP pilot project for functional characterization of identified proteins with no known function. Journal of Proteome Research. PMID 30269496 DOI: 10.1021/Acs.Jproteome.8B00383  0.345
2018 Omenn GS, Lane L, Overall CM, Corrales FJ, Schwenk JM, Paik YK, Van Eyk JE, Liu S, Snyder M, Baker MS, Deutsch EW. Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project. Journal of Proteome Research. PMID 30099871 DOI: 10.1021/Acs.Jproteome.8B00441  0.346
2018 Russo V, Klein T, Lim DJ, Solis N, Machado Y, Hiroyasu S, Nabai L, Shen Y, Zeglinski MR, Zhao H, Oram CP, Lennox PA, Van Laeken N, Carr NJ, Crawford RI, ... ... Overall CM, et al. Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction. Scientific Reports. 8: 9690. PMID 29946113 DOI: 10.1038/S41598-018-28070-0  0.348
2018 Dufour A, Bellac CL, Eckhard U, Solis N, Klein T, Kappelhoff R, Fortelny N, Jobin P, Rozmus J, Mark J, Pavlidis P, Dive V, Barbour SJ, Overall CM. C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease. Nature Communications. 9: 2416. PMID 29925830 DOI: 10.1038/S41467-018-04717-4  0.425
2018 Tharmarajah G, Eckhard U, Jain F, Marino G, Prudova A, Urtatiz O, Fuchs H, Hrabe de Angelis M, Overall CM, Van Raamsdonk CD. Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase. Pigment Cell & Melanoma Research. PMID 29781574 DOI: 10.1111/Pcmr.12711  0.338
2018 King SL, Goth CK, Eckhard U, Joshi HJ, Haue AD, Vakhrushev S, Schjoldager K, Overall CM, Wandall HH. TAILS N-Terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation. The Journal of Biological Chemistry. PMID 29593093 DOI: 10.1074/Jbc.Ra118.001978  0.404
2018 Jagdeo JM, Dufour A, Klein T, Solis N, Kleifeld O, Kizhakkedathu J, Luo H, Overall CM, Jan E. N-Terminomics TAILS identifies host cell substrates of poliovirus and coxsackievirus B3 3C proteinases that modulate virus infection. Journal of Virology. PMID 29437971 DOI: 10.1128/Jvi.02211-17  0.326
2018 Solis N, Overall CM. Identification of Protease Cleavage Sites and Substrates in Cancer by Carboxy-TAILS (C-TAILS). Methods in Molecular Biology (Clifton, N.J.). 1731: 15-28. PMID 29318539 DOI: 10.1007/978-1-4939-7595-2_2  0.345
2017 Klein T, Eckhard U, Dufour A, Solis N, Overall CM. Proteolytic Cleavage-Mechanisms, Function, and "Omic" Approaches for a Near-Ubiquitous Posttranslational Modification. Chemical Reviews. PMID 29265812 DOI: 10.1021/Acs.Chemrev.7B00120  0.392
2017 Paik YK, Overall CM, Deutsch EW, Van Eyk JE, Omenn GS. Progress and Future Direction of Chromosome-Centric Human Proteome Project. Journal of Proteome Research. 16: 4253-4258. PMID 29191025 DOI: 10.1021/Acs.Jproteome.7B00734  0.311
2017 Na CH, Barbhuiya M, Kim MS, Verbruggen S, Eacker S, Pletnikova O, Troncoso J, Halushka M, Menschaert G, Overall C, Pandey A. Discovery of non-canonical translation initiation sites through mass spectrometric analysis of protein N-termini. Genome Research. PMID 29162641 DOI: 10.1101/Gr.226050.117  0.337
2017 Paik YK, Omenn GS, Lane L, Overall CM. Advances in the Chromosome-Centric Human Proteome Project: Looking to the Future. Expert Review of Proteomics. PMID 29039980 DOI: 10.1080/14789450.2017.1394189  0.318
2017 Abbey SR, Eckhard U, Solis N, Marino G, Matthew I, Overall CM. The Human Odontoblast Cell Layer and Dental Pulp Proteomes and N-Terminomes. Journal of Dental Research. 22034517736054. PMID 29035686 DOI: 10.1177/0022034517736054  0.348
2017 Schwenk JM, Omenn GS, Sun Z, Campbell DS, Baker MS, Overall CM, Aebersold R, Moritz RL, Deutsch EW. The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays. Journal of Proteome Research. PMID 28938075 DOI: 10.1021/Acs.Jproteome.7B00467  0.307
2017 Eckhard U, Bandukwala H, Mansfield MJ, Marino G, Cheng J, Wallace I, Holyoak T, Charles TC, Austin J, Overall CM, Doxey AC. Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella. Nature Communications. 8: 521. PMID 28900095 DOI: 10.1038/S41467-017-00599-0  0.349
2017 Omenn GS, Lane L, Lundberg EK, Overall CM, Deutsch EW. Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project. Journal of Proteome Research. PMID 28853897 DOI: 10.1021/Acs.Jproteome.7B00375  0.336
2017 Kappelhoff R, Puente XS, Wilson CH, Seth A, Lopez-Otin C, Overall CM. Overview of transcriptomic analysis of all human proteases, non-proteolytic homologs and inhibitors: Organ, tissue and ovarian cancer cell line expression profiling of the human protease degradome by the CLIP-CHIP™ DNA microarray. Biochimica Et Biophysica Acta. PMID 28797648 DOI: 10.1016/J.Bbamcr.2017.08.004  0.341
2017 Panwar P, Butler GS, Jamroz A, Azizi P, Overall CM, Brömme D. Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 28634008 DOI: 10.1016/J.Matbio.2017.06.004  0.454
2017 Jobin PG, Butler GS, Overall CM. New intracellular activities of matrix metalloproteinases shine in the moonlight. Biochimica Et Biophysica Acta. PMID 28526562 DOI: 10.1016/J.Bbamcr.2017.05.013  0.526
2017 Fortelny N, Butler GS, Overall CM, Pavlidis P. Protease-inhibitor interaction predictions: Lessons on the complexity of protein-protein interactions. Molecular & Cellular Proteomics : McP. PMID 28385878 DOI: 10.1074/Mcp.M116.065706  0.317
2017 Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M. Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families. Scientific Reports. 7: 43135. PMID 28230157 DOI: 10.1038/Srep43135  0.399
2017 Taggart C, Mall MA, Lalmanach G, Cataldo D, Ludwig A, Janciauskiene S, Heath N, Meiners S, Overall CM, Schultz C, Turk B, Borensztajn KS. Protean proteases: at the cutting edge of lung diseases. The European Respiratory Journal. 49. PMID 28179435 DOI: 10.1183/13993003.01200-2015  0.416
2017 Marshall NC, Finlay BB, Overall CM. Sharpening host defenses during infection: Proteases cut to the chase. Molecular & Cellular Proteomics : McP. PMID 28179412 DOI: 10.1074/Mcp.O116.066456  0.328
2017 Scott NE, Rogers LD, Prudova A, Brown NF, Fortelny N, Overall CM, Foster LJ. Interactome disassembly during apoptosis occurs independent of caspase cleavage. Molecular Systems Biology. 13: 906. PMID 28082348 DOI: 10.15252/Msb.20167067  0.306
2016 Klein T, Viner RI, Overall CM. Quantitative proteomics and terminomics to elucidate the role of ubiquitination and proteolysis in adaptive immunity. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 374. PMID 27644975 DOI: 10.1098/Rsta.2015.0372  0.304
2016 Abdul-Muneer PM, Conte AA, Haldar D, Long M, Patel R, Santhakumar V, Overall CM, Pfister BJ. Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration. Brain, Behavior, and Immunity. PMID 27614125 DOI: 10.1016/J.Bbi.2016.09.002  0.425
2016 Qing X, Rogers L, Mortha A, Lavin Y, Redecha P, Issuree PD, Maretzky T, Merad M, McIlwain D, Mak TW, Overall CM, Blobel CP, Salmon JE. iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice. European Journal of Immunology. PMID 27601030 DOI: 10.1002/Eji.201646482  0.313
2016 Omenn GS, Lane L, Lundberg EK, Beavis RC, Overall CM, Deutsch EW. Metrics for the Human Proteome Project 2016: Progress on Identifying and Characterizing the Human Proteome, Including Post-Translational Modifications. Journal of Proteome Research. PMID 27487407 DOI: 10.1021/Acs.Jproteome.6B00511  0.353
2016 Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM. TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors. Cell Reports. PMID 27477282 DOI: 10.1016/J.Celrep.2016.06.086  0.688
2016 Butler GS, Connor AR, Sounni NE, Eckhard U, Morrison CJ, Noël A, Overall CM. Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2). Matrix Biology : Journal of the International Society For Matrix Biology. PMID 27471094 DOI: 10.1016/J.Matbio.2016.07.006  0.521
2016 Moon H, Cremmel CV, Kulpa A, Jaeger NA, Kappelhoff R, Overall CM, Waterfield JD, Brunette DM. Novel Grooved Substrata Stimulate Macrophage Fusion, CCL2 and MMP-9 Secretion. Journal of Biomedical Materials Research. Part A. PMID 27102570 DOI: 10.1002/Jbm.A.35757  0.318
2016 Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, ... ... Overall CM, et al. Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14. Data in Brief. 7: 299-310. PMID 26981551 DOI: 10.1016/J.Dib.2016.02.036  0.724
2016 Eckhard U, Marino G, Butler GS, Overall CM. Positional proteomics in the era of the human proteome project on the doorstep of precision medicine. Biochimie. 122: 110-8. PMID 26542287 DOI: 10.1016/J.Biochi.2015.10.018  0.403
2016 Tam V, Solis N, Overall C, Klein T, Cheung KMC, Cheah KSE, Chan D. Degradome of the Interverteral Disc Global Spine Journal. 6: s-0036-1582633-s-003. DOI: 10.1055/S-0036-1582633  0.435
2015 Hamey JJ, Winter DL, Yagoub D, Overall CM, Hart-Smith G, Wilkins MR. Novel N-terminal and lysine methyltransferases that target translation elongation factor 1A in yeast and human. Molecular & Cellular Proteomics : McP. PMID 26545399 DOI: 10.1074/Mcp.M115.052449  0.305
2015 Klein T, Fung SY, Renner F, Blank MA, Dufour A, Kang S, Bolger-Munro M, Scurll JM, Priatel JJ, Schweigler P, Melkko S, Gold MR, Viner RI, Régnier CH, Turvey SE, ... Overall CM, et al. The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling. Nature Communications. 6: 8777. PMID 26525107 DOI: 10.1038/Ncomms9777  0.318
2015 Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Keller UA, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, ... ... Overall CM, et al. Active site specificity of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26407638 DOI: 10.1016/J.Matbio.2015.09.003  0.734
2015 Eckhard U, Marino G, Abbey SR, Tharmarajah G, Matthew I, Overall CM. The Human Dental Pulp Proteome and N-Terminome: Levering the Unexplored Potential of Semitryptic Peptides Enriched by TAILS to Identify Missing Proteins in the Human Proteome Project in Underexplored Tissues. Journal of Proteome Research. 14: 3568-82. PMID 26258467 DOI: 10.1021/Acs.Jproteome.5B00579  0.4
2015 Marino G, Eckhard U, Overall CM. Protein Termini and Their Modifications Revealed by Positional Proteomics. Acs Chemical Biology. 10: 1754-64. PMID 26042555 DOI: 10.1021/Acschembio.5B00189  0.365
2015 Fortelny N, Pavlidis P, Overall CM. The path of no return-Truncated protein N-termini and current ignorance of their genesis. Proteomics. 15: 2547-52. PMID 26010509 DOI: 10.1002/Pmic.201500043  0.349
2015 Repnik U, Starr AE, Overall CM, Turk B. Cysteine Cathepsins Activate ELR Chemokines and Inactivate Non-ELR Chemokines. The Journal of Biological Chemistry. 290: 13800-11. PMID 25833952 DOI: 10.1074/Jbc.M115.638395  0.407
2015 Zelanis A, Huesgen PF, Oliveira AK, Tashima AK, Serrano SM, Overall CM. Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites. Journal of Proteomics. 113: 260-7. PMID 25452133 DOI: 10.1016/J.Jprot.2014.10.002  0.351
2015 Huesgen PF, Lange PF, Rogers LD, Solis N, Eckhard U, Kleifeld O, Goulas T, Gomis-Rüth FX, Overall CM. LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification Nature Methods. 12: 55-58. PMID 25419962 DOI: 10.1038/Nmeth.3177  0.667
2015 Fortelny N, Yang S, Pavlidis P, Lange PF, Overall CM. Proteome TopFIND 3.0 with TopFINDer and PathFINDer: database and analysis tools for the association of protein termini to pre- and post-translational events. Nucleic Acids Research. 43: D290-7. PMID 25332401 DOI: 10.1093/Nar/Gku1012  0.687
2015 Delolme F, Anastasi C, Alcaraz LB, Mendoza V, Vadon-Le Goff S, Talantikite M, Capomaccio R, Mevaere J, Fortin L, Mazzocut D, Damour O, Zanella-Cléon I, Hulmes DJ, Overall CM, Valcourt U, et al. Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics. Cellular and Molecular Life Sciences : Cmls. 72: 1009-27. PMID 25260970 DOI: 10.1007/S00018-014-1733-X  0.361
2015 Mallia-Milanes B, Dufour A, Bailey H, Meakin G, Leme A, Bolton C, Shapiro S, Overall C, Johnson S. S129 A two species proteomics approach to determine MMP-12 substrates in COPD Thorax. 70: A73.2-A74. DOI: 10.1136/Thoraxjnl-2015-207770.135  0.502
2014 Prudova A, Serrano K, Eckhard U, Fortelny N, Devine DV, Overall CM. TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage. Blood. 124: e49-60. PMID 25331112 DOI: 10.1182/Blood-2014-04-569640  0.4
2014 Bellac CL, Dufour A, Krisinger MJ, Loonchanta A, Starr AE, Auf dem Keller U, Lange PF, Goebeler V, Kappelhoff R, Butler GS, Burtnick LD, Conway EM, Roberts CR, Overall CM. Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis. Cell Reports. 9: 618-32. PMID 25310974 DOI: 10.1016/J.Celrep.2014.09.006  0.74
2014 Barré O, Dufour A, Eckhard U, Kappelhoff R, Béliveau F, Leduc R, Overall CM. Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries Plos One. 9. PMID 25211023 DOI: 10.1371/Journal.Pone.0105984  0.368
2014 Cruz R, Huesgen P, Riley SP, Wlodawer A, Faro C, Overall CM, Martinez JJ, Simões I. RC1339/APRc from Rickettsia conorii is a novel aspartic protease with properties of retropepsin-like enzymes. Plos Pathogens. 10: e1004324. PMID 25144529 DOI: 10.1371/Journal.Ppat.1004324  0.359
2014 Fortelny N, Cox JH, Kappelhoff R, Starr AE, Lange PF, Pavlidis P, Overall CM. Network analyses reveal pervasive functional regulation between proteases in the human protease web. Plos Biology. 12: e1001869. PMID 24865846 DOI: 10.1371/Journal.Pbio.1001869  0.731
2014 Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, ... ... Overall CM, et al. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nature Medicine. 20: 493-502. PMID 24784232 DOI: 10.1038/Nm.3508  0.442
2014 Lange PF, Huesgen PF, Nguyen K, Overall CM. Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. Journal of Proteome Research. 13: 2028-44. PMID 24555563 DOI: 10.1021/Pr401191W  0.684
2014 Huesgen PF, Lange PF, Overall CM. Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease. Proteomics. Clinical Applications. 8: 338-50. PMID 24497460 DOI: 10.1002/Prca.201300104  0.675
2014 Marino G, Huesgen PF, Eckhard U, Overall CM, Schröder WP, Funk C. Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity. The Biochemical Journal. 457: 335-46. PMID 24156403 DOI: 10.1042/Bj20130196  0.53
2014 Eckhard U, Huesgen PF, Brandstetter H, Overall CM. Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen. Journal of Proteomics. 100: 102-14. PMID 24125730 DOI: 10.1016/J.Jprot.2013.10.004  0.411
2014 Fahlman RP, Chen W, Overall CM. Absolute proteomic quantification of the activity state of proteases and proteolytic cleavages using proteolytic signature peptides and isobaric tags. Journal of Proteomics. 100: 79-91. PMID 24060996 DOI: 10.1016/J.Jprot.2013.09.006  0.412
2013 Huesgen PF, Alami M, Lange PF, Foster LJ, Schröder WP, Overall CM, Green BR. Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids. Plos One. 8: e74483. PMID 24066144 DOI: 10.1371/Journal.Pone.0074483  0.671
2013 Broder C, Arnold P, Goff SVL, Konerding MA, Bahr K, Müller S, Overall CM, Bond JS, Koudelka T, Tholey A, Hulmes DJS, Moali C, Becker-Pauly C. Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength Proceedings of the National Academy of Sciences of the United States of America. 110: 14219-14224. PMID 23940311 DOI: 10.1073/Pnas.1305464110  0.326
2013 Butler GS, Overall CM. Matrix metalloproteinase processing of signaling molecules to regulate inflammation. Periodontology 2000. 63: 123-48. PMID 23931058 DOI: 10.1111/Prd.12035  0.461
2013 Solomonson M, Huesgen PF, Wasney GA, Watanabe N, Gruninger RJ, Prehna G, Overall CM, Strynadka NC. Structure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system. The Journal of Biological Chemistry. 288: 17782-90. PMID 23620593 DOI: 10.1074/Jbc.M113.462036  0.395
2013 Dufour A, Overall CM. Missing the target: matrix metalloproteinase antitargets in inflammation and cancer. Trends in Pharmacological Sciences. 34: 233-42. PMID 23541335 DOI: 10.1016/J.Tips.2013.02.004  0.503
2013 Wilson CH, Indarto D, Doucet A, Pogson LD, Pitman MR, McNicholas K, Menz RI, Overall CM, Abbott CA. Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism. The Journal of Biological Chemistry. 288: 13936-49. PMID 23519473 DOI: 10.1074/Jbc.M112.445841  0.342
2013 auf dem Keller U, Prudova A, Eckhard U, Fingleton B, Overall CM. Systems-level analysis of proteolytic events in increased vascular permeability and complement activation in skin inflammation. Science Signaling. 6: rs2. PMID 23322905 DOI: 10.1126/Scisignal.2003512  0.458
2013 Lange PF, Overall CM. Protein TAILS: when termini tell tales of proteolysis and function. Current Opinion in Chemical Biology. 17: 73-82. PMID 23298954 DOI: 10.1016/J.Cbpa.2012.11.025  0.685
2013 Korpos É, Kadri N, Kappelhoff R, Wegner J, Overall CM, Weber E, Holmberg D, Cardell S, Sorokin L. The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes. 62: 531-42. PMID 23139348 DOI: 10.2337/Db12-0432  0.341
2013 Jefferson T, Auf Dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, ... ... Overall CM, et al. The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10 Cellular and Molecular Life Sciences. 70: 309-333. PMID 22940918 DOI: 10.1007/S00018-012-1106-2  0.434
2013 Tester AM, Cox JH, Connor AR, Starr AE, Dean RA, Puente XS, López-Otín C, Overall CM. Enhanced bioactivity of MMP-truncated CXCL8 in vitro and in vivo. Plos One. DOI: 10.1371/Journal.Pone.0000312.G007  0.479
2012 auf dem Keller U, Overall CM. CLIPPER: an add-on to the Trans-Proteomic Pipeline for the automated analysis of TAILS N-terminomics data. Biological Chemistry. 393: 1477-83. PMID 23667905 DOI: 10.1515/Hsz-2012-0269  0.326
2012 Patel TR, Butler G, McFarlane A, Xie I, Overall CM, Stetefeld J. Site specific cleavage mediated by MMPs regulates function of agrin. Plos One. 7: e43669. PMID 22984437 DOI: 10.1371/Journal.Pone.0043669  0.473
2012 Starr AE, Bellac CL, Dufour A, Goebeler V, Overall CM. Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities. The Journal of Biological Chemistry. 287: 13382-95. PMID 22367194 DOI: 10.1074/Jbc.M111.314179  0.559
2012 Starr AE, Dufour A, Maier J, Overall CM. Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16. The Journal of Biological Chemistry. 287: 5848-60. PMID 22147696 DOI: 10.1074/Jbc.M111.314609  0.508
2012 Lange PF, Huesgen PF, Overall CM. TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function. Nucleic Acids Research. 40: D351-61. PMID 22102574 DOI: 10.1093/Nar/Gkr1025  0.688
2012 Huesgen PF, Overall CM. N- and C-terminal degradomics: new approaches to reveal biological roles for plant proteases from substrate identification. Physiologia Plantarum. 145: 5-17. PMID 22023699 DOI: 10.1111/J.1399-3054.2011.01536.X  0.416
2011 Doucet A, Overall CM. Amino-Terminal Oriented Mass Spectrometry of Substrates (ATOMS) N-terminal sequencing of proteins and proteolytic cleavage sites by quantitative mass spectrometry. Methods in Enzymology. 501: 275-93. PMID 22078539 DOI: 10.1016/B978-0-12-385950-1.00013-4  0.41
2011 Kleifeld O, Doucet A, Prudova A, auf dem Keller U, Gioia M, Kizhakkedathu JN, Overall CM. Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates. Nature Protocols. 6: 1578-611. PMID 21959240 DOI: 10.1038/Nprot.2011.382  0.358
2011 Schilling O, Huesgen PF, Barré O, Overall CM. Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis. Methods in Molecular Biology (Clifton, N.J.). 781: 59-69. PMID 21877277 DOI: 10.1007/978-1-61779-276-2_4  0.332
2011 Schilling O, auf dem Keller U, Overall CM. Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites. Biological Chemistry. 392: 1031-7. PMID 21846260 DOI: 10.1515/Bc.2011.158  0.322
2011 Lange PF, Overall CM. TopFIND, a knowledgebase linking protein termini with function. Nature Methods. 8: 703-4. PMID 21822272 DOI: 10.1038/Nmeth.1669  0.653
2011 Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C. Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis. The Journal of Biological Chemistry. 286: 34271-85. PMID 21784845 DOI: 10.1074/Jbc.M111.222513  0.418
2011 Ferraro GB, Morrison CJ, Overall CM, Strittmatter SM, Fournier AE. Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage. The Journal of Biological Chemistry. 286: 31418-24. PMID 21768085 DOI: 10.1074/Jbc.M111.249169  0.368
2011 Becker-Pauly C, Barré O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM. Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Molecular & Cellular Proteomics : McP. 10: M111.009233. PMID 21693781 DOI: 10.1074/Mcp.M111.009233  0.38
2011 Jefferson T, ÄŒauÅ¡ević M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. The Journal of Biological Chemistry. 286: 27741-50. PMID 21646356 DOI: 10.1074/Jbc.M111.252718  0.387
2011 Doucet A, Kleifeld O, Kizhakkedathu JN, Overall CM. Identification of proteolytic products and natural protein N-termini by Terminal Amine Isotopic Labeling of Substrates (TAILS). Methods in Molecular Biology (Clifton, N.J.). 753: 273-87. PMID 21604129 DOI: 10.1007/978-1-61779-148-2_18  0.349
2011 Schilling O, auf dem Keller U, Overall CM. Protease specificity profiling by tandem mass spectrometry using proteome-derived peptide libraries. Methods in Molecular Biology (Clifton, N.J.). 753: 257-72. PMID 21604128 DOI: 10.1007/978-1-61779-148-2_17  0.339
2011 Schilling O, Huesgen PF, Barré O, Auf dem Keller U, Overall CM. Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry. Nature Protocols. 6: 111-20. PMID 21212787 DOI: 10.1038/Nprot.2010.178  0.361
2011 Doucet A, Overall CM. Broad coverage identification of multiple proteolytic cleavage site sequences in complex high molecular weight proteins using quantitative proteomics as a complement to edman sequencing. Molecular & Cellular Proteomics : McP. 10: M110.003533. PMID 20876890 DOI: 10.1074/Mcp.M110.003533  0.459
2011 Li Y, Ting R, Harwig CW, Auf Dem Keller U, Bellac CL, Lange PF, Inkster JAH, Schaffer P, Adam MJ, Ruth TJ, Overall CM, Perrin DM. Towards kit-like 18F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases Medchemcomm. 2: 942-949. DOI: 10.1039/C1Md00117E  0.69
2010 Cox JH, Starr AE, Kappelhoff R, Yan R, Roberts CR, Overall CM. Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression. Arthritis and Rheumatism. 62: 3645-55. PMID 21120997 DOI: 10.1002/Art.27757  0.423
2010 auf dem Keller U, Bellac CL, Li Y, Lou Y, Lange PF, Ting R, Harwig C, Kappelhoff R, Dedhar S, Adam MJ, Ruth TJ, Bénard F, Perrin DM, Overall CM. Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer. Cancer Research. 70: 7562-9. PMID 20729277 DOI: 10.1158/0008-5472.Can-10-1584  0.701
2010 Dezerega A, Osorio C, Mardones J, Mundi V, Dutzan N, Franco M, Gamonal J, Oyarzún A, Overall CM, Hernández M. Monocyte chemotactic protein-3: possible involvement in apical periodontitis chemotaxis. International Endodontic Journal. 43: 902-8. PMID 20646081 DOI: 10.1111/J.1365-2591.2010.01764.X  0.323
2010 Schilling O, Barré O, Huesgen PF, Overall CM. Proteome-wide analysis of protein carboxy termini: C terminomics. Nature Methods. 7: 508-11. PMID 20526347 DOI: 10.1038/Nmeth.1467  0.34
2010 Prudova A, auf dem Keller U, Butler GS, Overall CM. Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics. Molecular & Cellular Proteomics : McP. 9: 894-911. PMID 20305284 DOI: 10.1074/Mcp.M000050-Mcp201  0.485
2010 auf dem Keller U, Prudova A, Gioia M, Butler GS, Overall CM. A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products. Molecular & Cellular Proteomics : McP. 9: 912-27. PMID 20305283 DOI: 10.1074/Mcp.M000032-Mcp201  0.4
2010 Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, et al. Stromal regulation of vessel stability by MMP14 and TGFbeta. Disease Models & Mechanisms. 3: 317-32. PMID 20223936 DOI: 10.1242/Dmm.003863  0.401
2010 Kleifeld O, Doucet A, auf dem Keller U, Prudova A, Schilling O, Kainthan RK, Starr AE, Foster LJ, Kizhakkedathu JN, Overall CM. Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products. Nature Biotechnology. 28: 281-8. PMID 20208520 DOI: 10.1038/Nbt.1611  0.466
2010 Dezerega A, Pozo P, Hernández M, Oyarzún A, Rivera O, Dutzan N, Gutiérrez-Fernández A, Overall CM, Garrido M, Alcota M, Ortiz E, Gamonal J. Chemokine monocyte chemoattractant protein-3 in progressive periodontal lesions in patients with chronic periodontitis. Journal of Periodontology. 81: 267-76. PMID 20151806 DOI: 10.1902/Jop.2009.090406  0.305
2010 Butler GS, Dean RA, Morrison CJ, Overall CM. Identification of cellular MMP substrates using quantitative proteomics: isotope-coded affinity tags (ICAT) and isobaric tags for relative and absolute quantification (iTRAQ). Methods in Molecular Biology (Clifton, N.J.). 622: 451-70. PMID 20135298 DOI: 10.1007/978-1-60327-299-5_26  0.481
2010 Kappelhoff R, Auf dem Keller U, Overall CM. Analysis of the degradome with the CLIP-CHIP microarray. Methods in Molecular Biology (Clifton, N.J.). 622: 175-93. PMID 20135282 DOI: 10.1007/978-1-60327-299-5_10  0.348
2010 Wu Y, Dai J, Schmuckler NG, Bakdash N, Yoder MC, Overall CM, Colman RW. Cleaved high molecular weight kininogen inhibits tube formation of endothelial progenitor cells via suppression of matrix metalloproteinase 2 Journal of Thrombosis and Haemostasis. 8: 185-193. PMID 19874467 DOI: 10.1111/J.1538-7836.2009.03662.X  0.359
2010 Rodríguez D, Morrison CJ, Overall CM. Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics. Biochimica Et Biophysica Acta. 1803: 39-54. PMID 19800373 DOI: 10.1016/J.Bbamcr.2009.09.015  0.52
2010 Kleifeld O, Doucet A, Kizhakkedathu JN, Overall CM. System-wide proteomic identification of protease cleavage products by terminal amine isotopic labeling of substrates Nature Protocols. DOI: 10.1038/Nprot.2010.30  0.329
2009 Butler GS, Overall CM. Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting. Nature Reviews. Drug Discovery. 8: 935-48. PMID 19949400 DOI: 10.1038/Nrd2945  0.32
2009 Butler GS, Overall CM. Updated biological roles for matrix metalloproteinases and new "intracellular" substrates revealed by degradomics. Biochemistry. 48: 10830-45. PMID 19817485 DOI: 10.1021/Bi901656F  0.514
2009 Morrison CJ, Butler GS, Rodríguez D, Overall CM. Matrix metalloproteinase proteomics: substrates, targets, and therapy. Current Opinion in Cell Biology. 21: 645-53. PMID 19616423 DOI: 10.1016/J.Ceb.2009.06.006  0.507
2009 Maretzky T, Le Gall SM, Worpenberg-Pietruk S, Eder J, Overall CM, Huang XY, Poghosyan Z, Edwards DR, Blobel CP. Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer. Cancer Research. 69: 4573-6. PMID 19487280 DOI: 10.1158/0008-5472.Can-08-4766  0.311
2009 Starr AE, Overall CM. Chapter 13. Characterizing proteolytic processing of chemokines by mass spectrometry, biochemistry, neo-epitope antibodies and functional assays. Methods in Enzymology. 461: 281-307. PMID 19480924 DOI: 10.1016/S0076-6879(09)05413-5  0.329
2009 Hwang Q, Cheifetz S, Overall CM, McCulloch CA, Sodek J. Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation. Bmc Cancer. 9: 121. PMID 19386107 DOI: 10.1186/1471-2407-9-121  0.675
2009 Gioia M, Foster LJ, Overall CM. Cell-based identification of natural substrates and cleavage sites for extracellular proteases by SILAC proteomics. Methods in Molecular Biology (Clifton, N.J.). 539: 131-53. PMID 19377966 DOI: 10.1007/978-1-60327-003-8_8  0.473
2009 Maretzky T, Yang G, Ouerfelli O, Overall CM, Worpenberg S, Hassiepen U, Eder J, Blobel CP. Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. The Biochemical Journal. 420: 105-13. PMID 19207106 DOI: 10.1042/Bj20082127  0.413
2009 Butler GS, Dean RA, Smith D, Overall CM. Membrane protease degradomics: proteomic identification and quantification of cell surface protease substrates. Methods in Molecular Biology (Clifton, N.J.). 528: 159-76. PMID 19153692 DOI: 10.1007/978-1-60327-310-7_12  0.434
2009 Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M. The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B. Journal of Molecular Biology. 386: 419-34. PMID 19109975 DOI: 10.1016/J.Jmb.2008.12.021  0.519
2008 Dean RA, Cox JH, Bellac CL, Doucet A, Starr AE, Overall CM. Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood. 112: 3455-64. PMID 18660381 DOI: 10.1182/Blood-2007-12-129080  0.483
2008 Doucet A, Butler GS, Rodríguez D, Prudova A, Overall CM. Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome. Molecular & Cellular Proteomics : McP. 7: 1925-51. PMID 18596063 DOI: 10.1074/Mcp.R800012-Mcp200  0.452
2008 Doucet A, Overall CM. Protease proteomics: revealing protease in vivo functions using systems biology approaches. Molecular Aspects of Medicine. 29: 339-58. PMID 18571712 DOI: 10.1016/J.Mam.2008.04.003  0.432
2008 Lin M, Jackson P, Tester AM, Diaconu E, Overall CM, Blalock JE, Pearlman E. Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro. The American Journal of Pathology. 173: 144-53. PMID 18556780 DOI: 10.2353/Ajpath.2008.080081  0.461
2008 Butler GS, Dean RA, Tam EM, Overall CM. Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding. Molecular and Cellular Biology. 28: 4896-914. PMID 18505826 DOI: 10.1128/Mcb.01775-07  0.773
2008 Schilling O, Overall CM. Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites. Nature Biotechnology. 26: 685-94. PMID 18500335 DOI: 10.1038/Nbt1408  0.367
2008 Cox JH, Dean RA, Roberts CR, Overall CM. Matrix metalloproteinase processing of CXCL11/I-TAC results in loss of chemoattractant activity and altered glycosaminoglycan binding. The Journal of Biological Chemistry. 283: 19389-99. PMID 18411283 DOI: 10.1074/Jbc.M800266200  0.5
2008 Cheung C, Marchant D, Walker EK, Luo Z, Zhang J, Yanagawa B, Rahmani M, Cox J, Overall C, Senior RM, Luo H, McManus BM. Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice. Circulation. 117: 1574-82. PMID 18332263 DOI: 10.1161/Circulationaha.107.733238  0.432
2008 Ajami K, Pitman MR, Wilson CH, Park J, Menz RI, Starr AE, Cox JH, Abbott CA, Overall CM, Gorrell MD. Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. Febs Letters. 582: 819-25. PMID 18275857 DOI: 10.1016/J.Febslet.2008.02.005  0.369
2008 Folgueras AR, Fueyo A, García-Suárez O, Cox J, Astudillo A, Tortorella P, Campestre C, Gutiérrez-Fernández A, Fanjul-Fernández M, Pennington CJ, Edwards DR, Overall CM, López-Otín C. Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice. The Journal of Biological Chemistry. 283: 9465-74. PMID 18245084 DOI: 10.1074/Jbc.M709522200  0.474
2008 auf dem Keller U, Doucet A, Overall CM. Protease research in the era of systems biology. Biological Chemistry. 388: 1159-62. PMID 17976008 DOI: 10.1515/Bc.2007.146  0.36
2008 Marchant D, Cheung C, Walker EK, Luo H, Luo Z, Zhang J, Yanagawa B, Rahmani M, McManus BM, Cox J, Overall C, Senior RM. Response to Letter Regarding Article, “Ablation of Matrix Metalloproteinase-9 Increases Severity of Viral Myocarditis in Mice” Circulation. 118. DOI: 10.1161/Circulationaha.108.794024  0.463
2007 Kappelhoff R, Overall C. The CLIP-CHIP oligonucleotide microarray: dedicated array for analysis of all protease, nonproteolytic homolog, and inhibitor gene transcripts in human and mouse. Current Protocols in Protein Science. 56. PMID 19365791 DOI: 10.1002/0471140864.Ps2119S56  0.302
2007 Dean RA, Smith D, Overall CM. Proteomic identification of cellular protease substrates using isobaric tags for relative and absolute quantification (iTRAQ). Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 21.18. PMID 18429318 DOI: 10.1002/0471140864.Ps2118S49  0.399
2007 Overall CM, Butler GS. Protease yoga: extreme flexibility of a matrix metalloproteinase. Structure (London, England : 1993). 15: 1159-61. PMID 17937904 DOI: 10.1016/J.Str.2007.10.001  0.458
2007 Kim M, Hamilton SE, Guddat LW, Overall CM. Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger. Biochimica Et Biophysica Acta. 1770: 1627-35. PMID 17920199 DOI: 10.1016/J.Bbagen.2007.08.003  0.306
2007 Dean RA, Butler GS, Hamma-Kourbali Y, Delbé J, Brigstock DR, Courty J, Overall CM. Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis. Molecular and Cellular Biology. 27: 8454-65. PMID 17908800 DOI: 10.1128/Mcb.00821-07  0.522
2007 Wolf K, Wu YI, Liu Y, Geiger J, Tam E, Overall C, Stack MS, Friedl P. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nature Cell Biology. 9: 893-904. PMID 17618273 DOI: 10.1038/Ncb1616  0.749
2007 Tester AM, Cox JH, Connor AR, Starr AE, Dean RA, Puente XS, López-Otín C, Overall CM. LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. Plos One. 2: e312. PMID 17375198 DOI: 10.1371/Journal.Pone.0000312  0.49
2007 Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Moss ML, Fields GB. Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences. Biochemistry. 46: 3724-33. PMID 17338550 DOI: 10.1021/Bi062199J  0.512
2007 Butler GS, Overall CM. Proteomic validation of protease drug targets: pharmacoproteomics of matrix metalloproteinase inhibitor drugs using isotope-coded affinity tag labelling and tandem mass spectrometry. Current Pharmaceutical Design. 13: 263-70. PMID 17313360 DOI: 10.2174/138161207779313524  0.373
2007 Overall CM, Blobel CP. In search of partners: linking extracellular proteases to substrates. Nature Reviews. Molecular Cell Biology. 8: 245-57. PMID 17299501 DOI: 10.1038/Nrm2120  0.374
2007 Iida J, Wilhelmson KL, Ng J, Lee P, Morrison C, Tam E, Overall CM, McCarthy JB. Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A). The Biochemical Journal. 403: 553-63. PMID 17217338 DOI: 10.1042/Bj20061176  0.769
2007 Dean RA, Overall CM. Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome. Molecular & Cellular Proteomics : McP. 6: 611-23. PMID 17200105 DOI: 10.1074/Mcp.M600341-Mcp200  0.547
2006 Schilling O, Overall CM. Proteomic discovery of protease substrates. Current Opinion in Chemical Biology. 11: 36-45. PMID 17194619 DOI: 10.1016/J.Cbpa.2006.11.037  0.428
2006 Vergote D, Butler GS, Ooms M, Cox JH, Silva C, Hollenberg MD, Jhamandas JH, Overall CM, Power C. Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 103: 19182-7. PMID 17148615 DOI: 10.1073/Pnas.0604678103  0.359
2006 Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Visse R, Nagase H, Fields GB. The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity. The Journal of Biological Chemistry. 281: 38302-13. PMID 17065155 DOI: 10.1074/Jbc.M606004200  0.511
2006 Lee H, Overall CM, McCulloch CA, Sodek J. A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis. Molecular Biology of the Cell. 17: 4812-26. PMID 16971509 DOI: 10.1091/Mbc.E06-06-0486  0.69
2006 Morrison CJ, Overall CM. TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains. The Journal of Biological Chemistry. 281: 26528-39. PMID 16825197 DOI: 10.1074/Jbc.M603331200  0.511
2006 Hasan L, Mazzucchelli L, Liebi M, Lis M, Hunger RE, Tester A, Overall CM, Wolf M. Function of liver activation-regulated chemokine/CC chemokine ligand 20 is differently affected by cathepsin B and cathepsin D processing. Journal of Immunology (Baltimore, Md. : 1950). 176: 6512-22. PMID 16709808 DOI: 10.4049/Jimmunol.176.11.6512  0.355
2006 Overall CM, Dean RA. Degradomics: systems biology of the protease web. Pleiotropic roles of MMPs in cancer. Cancer Metastasis Reviews. 25: 69-75. PMID 16680573 DOI: 10.1007/S10555-006-7890-0  0.555
2006 Overall CM, Kleifeld O. Towards third generation matrix metalloproteinase inhibitors for cancer therapy British Journal of Cancer. 94: 941-946. PMID 16538215 DOI: 10.1038/Sj.Bjc.6603043  0.466
2006 Overall CM, Kleifeld O. Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nature Reviews. Cancer. 6: 227-39. PMID 16498445 DOI: 10.1038/Nrc1821  0.453
2005 Nisato RE, Hosseini G, Sirrenberg C, Butler GS, Crabbe T, Docherty AJ, Wiesner M, Murphy G, Overall CM, Goodman SL, Pepper MS. Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical. Cancer Research. 65: 9377-87. PMID 16230401 DOI: 10.1158/0008-5472.Can-05-1512  0.46
2005 Nour N, Mayer G, Mort JS, Salvas A, Mbikay M, Morrison CJ, Overall CM, Seidah NG. The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases Molecular Biology of the Cell. 16: 5215-5226. PMID 16135528 DOI: 10.1091/Mbc.E05-06-0504  0.357
2005 Overall CM. Dilating the degradome: matrix metalloproteinase 2 (MMP-2) cuts to the heart of the matter. The Biochemical Journal. 383: e5-7. PMID 15508185 DOI: 10.1042/Bj20041433  0.488
2004 Pelman GR, Morrison CJ, Overall CM. Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3' subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond. The Journal of Biological Chemistry. 280: 2370-7. PMID 15533938 DOI: 10.1074/Jbc.M409603200  0.458
2004 Tam EM, Moore TR, Butler GS, Overall CM. Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in collagen triple helicase activities. The Journal of Biological Chemistry. 279: 43336-44. PMID 15292230 DOI: 10.1074/Jbc.M407186200  0.765
2004 Overall CM, Tam EM, Kappelhoff R, Connor A, Ewart T, Morrison CJ, Puente X, López-Otín C, Seth A. Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors. Biological Chemistry. 385: 493-504. PMID 15255181 DOI: 10.1515/Bc.2004.058  0.772
2004 Tam EM, Morrison CJ, Wu YI, Stack MS, Overall CM. Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proceedings of the National Academy of Sciences of the United States of America. 101: 6917-22. PMID 15118097 DOI: 10.1073/Pnas.0305862101  0.779
2004 Butler GS, Tam EM, Overall CM. The canonical methionine 392 of matrix metalloproteinase 2 (gelatinase A) is not required for catalytic efficiency or structural integrity: probing the role of the methionine-turn in the metzincin metalloprotease superfamily. The Journal of Biological Chemistry. 279: 15615-20. PMID 14732714 DOI: 10.1074/Jbc.M312727200  0.772
2003 Balbín M, Fueyo A, Tester AM, Pendás AM, Pitiot AS, Astudillo A, Overall CM, Shapiro SD, López-Otín C. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nature Genetics. 35: 252-7. PMID 14517555 DOI: 10.1038/Ng1249  0.431
2003 Zhang K, McQuibban GA, Silva C, Butler GS, Johnston JB, Holden J, Clark-Lewis I, Overall CM, Power C. HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration. Nature Neuroscience. 6: 1064-71. PMID 14502291 DOI: 10.1038/Nn1127  0.757
2003 Puente XS, Sánchez LM, Overall CM, López-Otín C. Human and mouse proteases: a comparative genomic approach. Nature Reviews. Genetics. 4: 544-58. PMID 12838346 DOI: 10.1038/Nrg1111  0.309
2003 Overall CM. Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites. Molecular Biotechnology. 22: 51-86. PMID 12353914 DOI: 10.1385/Mb:22:1:051  0.488
2002 Radomski A, Jurasz P, Sanders EJ, Overall CM, Bigg HF, Edwards DR, Radomski MW. Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets British Journal of Pharmacology. 137: 1330-1338. PMID 12466243 DOI: 10.1038/Sj.Bjp.0704936  0.368
2002 Overall CM, McQuibban GA, Clark-Lewis I. Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics. Biological Chemistry. 383: 1059-66. PMID 12437088 DOI: 10.1515/Bc.2002.114  0.792
2002 Kai HS, Butler GS, Morrison CJ, King AE, Pelman GR, Overall CM. Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain. The Journal of Biological Chemistry. 277: 48696-707. PMID 12374789 DOI: 10.1074/Jbc.M209177200  0.481
2002 Overall CM, López-Otín C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nature Reviews. Cancer. 2: 657-72. PMID 12209155 DOI: 10.1038/Nrc884  0.489
2002 McQuibban GA, Gong JH, Wong JP, Wallace JL, Clark-Lewis I, Overall CM. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood. 100: 1160-7. PMID 12149192 DOI: 10.1182/Blood.V100.4.1160.H81602001160_1160_1167  0.79
2002 Tam EM, Wu YI, Butler GS, Stack MS, Overall CM. Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage. The Journal of Biological Chemistry. 277: 39005-14. PMID 12145314 DOI: 10.1074/Jbc.M206874200  0.768
2002 López-Otín C, Overall CM. Protease degradomics: a new challenge for proteomics. Nature Reviews. Molecular Cell Biology. 3: 509-19. PMID 12094217 DOI: 10.1038/Nrm858  0.308
2002 Butler GS, Sim D, Tam E, Devine D, Overall CM. Mannose-binding lectin (MBL) mutants are susceptible to matrix metalloproteinase proteolysis: potential role in human MBL deficiency. The Journal of Biological Chemistry. 277: 17511-9. PMID 11891230 DOI: 10.1074/Jbc.M201461200  0.765
2002 Saad S, Gottlieb DJ, Bradstock KF, Overall CM, Bendall LJ. Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts. Cancer Research. 62: 283-9. PMID 11782389  0.363
2002 OVERALL C, KING A, SAM D, ONG A, LAU T, WALLON U, DECLERCK Y, ATHERSTONE J. Identification of the TIMP-2 binding site on the hemopexin domain of human gelatinase A by site-directed mutagenesis International Journal of Experimental Pathology. 79: A40-A41. DOI: 10.1046/J.1365-2613.1998.T01-31-750408.X  0.306
2001 Morrison CJ, Butler GS, Bigg HF, Roberts CR, Soloway PD, Overall CM. Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway. The Journal of Biological Chemistry. 276: 47402-10. PMID 11584019 DOI: 10.1074/Jbc.M108643200  0.512
2001 McQuibban GA, Butler GS, Gong JH, Bendall L, Power C, Clark-Lewis I, Overall CM. Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. The Journal of Biological Chemistry. 276: 43503-8. PMID 11571304 DOI: 10.1074/Jbc.M107736200  0.793
2001 Ellerbroek SM, Wu YI, Overall CM, Stack MS. Functional interplay between type I collagen and cell surface matrix metalloproteinase activity. The Journal of Biological Chemistry. 276: 24833-42. PMID 11331272 DOI: 10.1074/Jbc.M005631200  0.504
2001 Kang T, Yi J, Guo A, Wang X, Overall CM, Jiang W, Elde R, Borregaard N, Pei D. Subcellular Distribution and Cytokine- and Chemokine-regulated Secretion of Leukolysin/MT6-MMP/MMP-25 in Neutrophils Journal of Biological Chemistry. 276: 21960-21968. PMID 11282999 DOI: 10.1074/Jbc.M007997200  0.495
2001 Toth M, Bernardo MM, Gervasi DC, Soloway PD, Wang Z, Bigg HF, Overall CM, DeClerck YA, Tschesche H, Cher ML, Brown S, Mobashery S, Fridman R. Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2. The Journal of Biological Chemistry. 275: 41415-23. PMID 10998420 DOI: 10.1074/Jbc.M006871200  0.406
2001 Overall CM. Matrix MetaIIoproteinase Substrate Binding Domains, Modules and Exosites Methods of Molecular Biology. 151: 79-120. DOI: 10.1385/1-59259-046-2:079  0.373
2000 Overall CM, Tam E, McQuibban GA, Morrison C, Wallon UM, Bigg HF, King AE, Roberts CR. Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation. The Journal of Biological Chemistry. 275: 39497-506. PMID 10991943 DOI: 10.1074/jbc.M005932200  0.77
2000 McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I, Overall CM. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science (New York, N.Y.). 289: 1202-6. PMID 10947989 DOI: 10.1126/Science.289.5482.1202  0.807
2000 Bhide VM, Smith L, Overall CM, Birek P, McCulloch CA. Use of a fluorogenic septapeptide matrix metalloproteinase assay to assess responses to periodontal treatment. Journal of Periodontology. 71: 690-700. PMID 10872948 DOI: 10.1902/Jop.2000.71.5.690  0.422
2000 Martin-De Las Heras S, Valenzuela A, Overall CM. The matrix metalloproteinase gelatinase A in human dentine. Archives of Oral Biology. 45: 757-65. PMID 10869489 DOI: 10.1016/S0003-9969(00)00052-2  0.311
2000 Brayer GD, Sidhu G, Maurus R, Rydberg EH, Braun C, Wang Y, Nguyen NT, Overall CM, Withers SG. Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry. 39: 4778-91. PMID 10769135 DOI: 10.1021/Bi9921182  0.332
1999 Mancini S, Romanelli R, Laschinger CA, Overall CM, Sodek J, McCulloch CA. Assessment of a novel screening test for neutrophil collagenase activity in the diagnosis of periodontal diseases. Journal of Periodontology. 70: 1292-302. PMID 10588492 DOI: 10.1902/Jop.1999.70.11.1292  0.603
1999 Overall CM, King AE, Bigg HF, McQuibban A, Atherstone J, Sam DK, Ong AD, Lau TT, Wallon UM, DeClerck YA, Tam E. Identification of the TIMP-2 binding site on the gelatinase A hemopexin C-domain by site-directed mutagenesis and the yeast two-hybrid system. Annals of the New York Academy of Sciences. 878: 747-53. PMID 10415826 DOI: 10.1111/J.1749-6632.1999.Tb07780.X  0.672
1999 Romanelli R, Mancini S, Laschinger C, Overall CM, Sodek J, McCulloch CA. Activation of neutrophil collagenase in periodontitis. Infection and Immunity. 67: 2319-26. PMID 10225890 DOI: 10.1128/Iai.67.5.2319-2326.1999  0.679
1999 Rydberg EH, Sidhu G, Vo HC, Hewitt J, Côte HC, Wang Y, Numao S, MacGillivray RT, Overall CM, Brayer GD, Withers SG. Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris. Protein Science : a Publication of the Protein Society. 8: 635-43. PMID 10091666 DOI: 10.1110/Ps.8.3.635  0.356
1998 Steffensen B, Bigg HF, Overall CM. The involvement of the fibronectin type II-like modules of human gelatinase A in cell surface localization and activation. The Journal of Biological Chemistry. 273: 20622-8. PMID 9685420 DOI: 10.1074/Jbc.273.32.20622  0.41
1998 Sutinen M, Kainulainen T, Hurskainen T, Vesterlund E, Alexander JP, Overall CM, Sorsa T, Salo T. Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis British Journal of Cancer. 77: 2239-2245. PMID 9649139 DOI: 10.1038/Bjc.1998.372  0.434
1997 Maurus R, Overall CM, Bogumil R, Luo Y, Mauk AG, Smith M, Brayer GD. A myoglobin variant with a polar substitution in a conserved hydrophobic cluster in the heme binding pocket. Biochimica Et Biophysica Acta. 1341: 1-13. PMID 9300804 DOI: 10.1016/S0167-4838(97)00064-2  0.392
1997 Iamaroon A, Wallon UM, Overall CM, Diewert VM. Expression of 72-kDa gelatinase (matrix metalloproteinase-2) in the developing mouse craniofacial complex. Archives of Oral Biology. 41: 1109-19. PMID 9134100 DOI: 10.1016/S0003-9969(96)00097-0  0.466
1995 Overall CM. Repression of tissue inhibitor of matrix metalloproteinase expression by all-trans-retinoic acid in rat bone cell populations: comparison with transforming growth factor-beta 1. Journal of Cellular Physiology. 164: 17-25. PMID 7790389 DOI: 10.1002/Jcp.1041640104  0.396
1995 Steffensen B, Wallon UM, Overall CM. Extracellular matrix binding properties of recombinant fibronectin type II-like modules of human 72-kDa gelatinase/type IV collagenase. High affinity binding to native type I collagen but not native type IV collagen. The Journal of Biological Chemistry. 270: 11555-66. PMID 7744795 DOI: 10.1074/Jbc.270.19.11555  0.405
1994 Overall CM. Regulation of tissue inhibitor of matrix metalloproteinase expression. Annals of the New York Academy of Sciences. 732: 51-64. PMID 7978851 DOI: 10.1111/J.1749-6632.1994.Tb24724.X  0.413
1993 Dedhar S, Saulnier R, Nagle R, Overall CM. Specific alterations in the expression of alpha 3 beta 1 and alpha 6 beta 4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane. Clinical & Experimental Metastasis. 11: 391-400. PMID 8375114 DOI: 10.1007/Bf00132982  0.307
1992 Sodek J, Overall CM. Matrix metalloproteinases in periodontal tissue remodelling. Matrix (Stuttgart, Germany). Supplement. 1: 352-62. PMID 1480060  0.619
1992 Overall CM, Sodek J. Reciprocal regulation of collagenase, 72 kDa-gelatinase, and TIMP gene expression and protein synthesis in human fibroblasts induced by concanavalin A. Matrix (Stuttgart, Germany). Supplement. 1: 209-11. PMID 1480028  0.53
1991 Wrana JL, Kubota T, Zhang Q, Overall CM, Aubin JE, Butler WT, Sodek J. Regulation of transformation-sensitive secreted phosphoprotein (SPPI/osteopontin) expression by transforming growth factor-beta. Comparisons with expression of SPARC (secreted acidic cysteine-rich protein). The Biochemical Journal. 273: 523-31. PMID 1996953 DOI: 10.1042/Bj2730523  0.669
1991 Kasugai S, Zhang Q, Overall CM, Wrana JL, Butler WT, Sodek J. Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter. Bone and Mineral. 13: 235-50. PMID 1863811 DOI: 10.1016/0169-6009(91)90071-7  0.66
1991 Overall CM, Wrana JL, Sodek J. Induction of formative and resorptive cellular phenotypes in human gingival fibroblasts by TGF-beta 1 and concanavalin A: regulation of matrix metalloproteinases and TIMP. Journal of Periodontal Research. 26: 279-82. PMID 1831853 DOI: 10.1111/J.1600-0765.1991.Tb01658.X  0.702
1991 Wrana JL, Overall CM, Sodek J. Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen. European Journal of Biochemistry. 197: 519-28. PMID 1709099 DOI: 10.1111/J.1432-1033.1991.Tb15940.X  0.634
1991 Lee W, Aitken S, Kulkarni G, Birek P, Overall CM, Sodek J, McCulloch CA. Collagenase activity in recurrent periodontitis: relationship to disease progression and doxycycline therapy. Journal of Periodontal Research. 26: 479-85. PMID 1662266 DOI: 10.1111/J.1600-0765.1991.Tb01798.X  0.56
1991 Overall CM, Sodek J, McCulloch CA, Birek P. Evidence for polymorphonuclear leukocyte collagenase and 92-kilodalton gelatinase in gingival crevicular fluid. Infection and Immunity. 59: 4687-92. PMID 1657787 DOI: 10.1128/Iai.59.12.4687-4692.1991  0.557
1991 Overall CM, Wrana JL, Sodek J. Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression. The Journal of Biological Chemistry. 266: 14064-71. PMID 1649834  0.59
1991 OVERALL CM. Recent Advances in Matrix Metalloproteinase Research. Trends in Glycoscience and Glycotechnology. 3: 384-399. DOI: 10.4052/Tigg.3.384  0.464
1990 Overall CM, Sodek J. Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases. The Journal of Biological Chemistry. 265: 21141-51. PMID 2174435  0.658
1990 Gangbar S, Overall CM, McCulloch CA, Sodek J. Identification of polymorphonuclear leukocyte collagenase and gelatinase activities in mouthrinse samples: correlation with periodontal disease activity in adult and juvenile periodontitis. Journal of Periodontal Research. 25: 257-67. PMID 2170617 DOI: 10.1111/J.1600-0765.1990.Tb00914.X  0.578
1989 Overall CM, Limeback H. Identification and characterization of enamel proteinases isolated from developing enamel. Amelogeninolytic serine proteinases are associated with enamel maturation in pig. The Biochemical Journal. 256: 965-72. PMID 3223966 DOI: 10.1042/Bj2560965  0.421
1989 Overall CM, Wrana JL, Sodek J. Transforming growth factor-beta regulation of collagenase, 72 kDa-progelatinase, TIMP and PAI-1 expression in rat bone cell populations and human fibroblasts. Connective Tissue Research. 20: 289-94. PMID 2558843 DOI: 10.3109/03008208909023899  0.649
1989 Overall CM, Wrana JL, Sodek J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. The Journal of Biological Chemistry. 264: 1860-9. PMID 2536374  0.554
1988 Drouin L, Overall CM, Sodek J. Identification of matrix metalloendoproteinase inhibitor (TIMP) in human parotid and submandibular saliva: partial purification and characterization. Journal of Periodontal Research. 23: 370-7. PMID 2851041 DOI: 10.1111/J.1600-0765.1988.Tb01615.X  0.621
1988 Otsuka K, Pitaru S, Overall CM, Aubin JE, Sodek J. Biochemical comparison of fibroblast populations from different periodontal tissues: characterization of matrix protein and collagenolytic enzyme synthesis. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 66: 167-76. PMID 2838055 DOI: 10.1139/O88-023  0.618
1987 Overall CM, Sodek J. Initial characterization of a neutral metalloproteinase, active on native 3/4-collagen fragments, synthesized by ROS 17/2.8 osteoblastic cells, periodontal fibroblasts, and identified in gingival crevicular fluid. Journal of Dental Research. 66: 1271-82. PMID 3040831 DOI: 10.1177/00220345870660071201  0.654
1987 Overall CM, Wiebkin OW, Thonard JC. Demonstration of tissue collagenase activity in vivo and its relationship to inflammation severity in human gingiva. Journal of Periodontal Research. 22: 81-8. PMID 3035163 DOI: 10.1111/J.1600-0765.1987.Tb01544.X  0.377
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