Christopher M. Overall - Publications

University of British Columbia, Vancouver, Vancouver, BC, Canada 
Molecular Biology

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Jobin PG, Solis N, Machado Y, Bell PA, Rai SK, Kwon NH, Kim S, Overall CM, Butler GS. Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage. The Journal of Biological Chemistry. PMID 31771979 DOI: 10.1074/jbc.RA119.010486  0.36
2019 Zelanis A, Oliveira AK, Prudova A, Huesgen PF, Tashima AK, Kizhakkedathu J, Overall CM, de Toledo Serrano SM. Deep profiling of the cleavage specificity and human substrates of snake venom metalloprotease HF3 by PICS using proteome derived peptide libraries and TAILS N-terminomics. Journal of Proteome Research. PMID 31337208 DOI: 10.1021/acs.jproteome.9b00325  0.52
2019 Jobin PG, Solis N, Machado Y, Bell PA, Kwon NH, Kim S, Overall CM, Butler GS. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase. The Journal of Biological Chemistry. PMID 31324718 DOI: 10.1074/jbc.RA119.009584  0.36
2018 Vinh NB, Drinkwater N, Malcolm TR, Kassiou M, Lucantoni L, Grin PM, Butler GS, Duffy S, Overall CM, Avery VM, Scammells PJ, McGowan S. Hydroxamic acid inhibitors provide cross-species inhibition of Plasmodium M1 and M17 aminopeptidases. Journal of Medicinal Chemistry. PMID 30537832 DOI: 10.1021/acs.jmedchem.8b01310  0.36
2017 Panwar P, Butler GS, Jamroz A, Azizi P, Overall CM, Brömme D. Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 28634008 DOI: 10.1016/j.matbio.2017.06.004  0.36
2017 Jobin PG, Butler GS, Overall CM. New intracellular activities of matrix metalloproteinases shine in the moonlight. Biochimica Et Biophysica Acta. PMID 28526562 DOI: 10.1016/j.bbamcr.2017.05.013  0.36
2017 Fortelny N, Butler GS, Overall CM, Pavlidis P. Protease-inhibitor interaction predictions: Lessons on the complexity of protein-protein interactions. Molecular & Cellular Proteomics : McP. PMID 28385878 DOI: 10.1074/mcp.M116.065706  0.36
2016 Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM. TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors. Cell Reports. PMID 27477282 DOI: 10.1016/j.celrep.2016.06.086  0.64
2016 Butler GS, Connor AR, Sounni NE, Eckhard U, Morrison CJ, Noël A, Overall CM. Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2). Matrix Biology : Journal of the International Society For Matrix Biology. PMID 27471094 DOI: 10.1016/j.matbio.2016.07.006  0.36
2016 Moon H, Cremmel CV, Kulpa A, Jaeger NA, Kappelhoff R, Overall CM, Waterfield JD, Brunette DM. Novel Grooved Substrata Stimulate Macrophage Fusion, CCL2 and MMP-9 Secretion. Journal of Biomedical Materials Research. Part A. PMID 27102570 DOI: 10.1002/jbm.a.35757  0.64
2016 Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, ... ... Overall CM, et al. Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14. Data in Brief. 7: 299-310. PMID 26981551 DOI: 10.1016/j.dib.2016.02.036  0.6
2016 Eckhard U, Marino G, Butler GS, Overall CM. Positional proteomics in the era of the human proteome project on the doorstep of precision medicine. Biochimie. 122: 110-8. PMID 26542287 DOI: 10.1016/j.biochi.2015.10.018  0.36
2015 Eckhard U, Marino G, Abbey SR, Matthew I, Overall CM. TAILS N-terminomic and proteomic datasets of healthy human dental pulp. Data in Brief. 5: 542-8. PMID 26587561 DOI: 10.1016/j.dib.2015.10.003  0.64
2015 Hamey JJ, Winter DL, Yagoub D, Overall CM, Hart-Smith G, Wilkins MR. Novel N-terminal and lysine methyltransferases that target translation elongation factor 1A in yeast and human. Molecular & Cellular Proteomics : McP. PMID 26545399 DOI: 10.1074/mcp.M115.052449  0.64
2015 Klein T, Fung SY, Renner F, Blank MA, Dufour A, Kang S, Bolger-Munro M, Scurll JM, Priatel JJ, Schweigler P, Melkko S, Gold MR, Viner RI, Régnier CH, Turvey SE, ... Overall CM, et al. The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling. Nature Communications. 6: 8777. PMID 26525107 DOI: 10.1038/ncomms9777  0.64
2015 Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Keller UA, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, ... ... Overall CM, et al. Active site specificity of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26407638 DOI: 10.1016/j.matbio.2015.09.003  0.6
2015 Paik YK, Omenn GS, Overall CM, Deutsch EW, Hancock WS. Recent Advances in the Chromosome-Centric Human Proteome Project: Missing Proteins in the Spot Light. Journal of Proteome Research. 14: 3409-14. PMID 26337862 DOI: 10.1021/acs.jproteome.5b00785  0.64
2015 Eckhard U, Marino G, Abbey SR, Tharmarajah G, Matthew I, Overall CM. The Human Dental Pulp Proteome and N-Terminome: Levering the Unexplored Potential of Semitryptic Peptides Enriched by TAILS to Identify Missing Proteins in the Human Proteome Project in Underexplored Tissues. Journal of Proteome Research. 14: 3568-82. PMID 26258467 DOI: 10.1021/acs.jproteome.5b00579  0.64
2015 Fortelny N, Pavlidis P, Overall CM. The path of no return-Truncated protein N-termini and current ignorance of their genesis. Proteomics. 15: 2547-52. PMID 26010509 DOI: 10.1002/pmic.201500043  0.64
2015 Jagdeo JM, Dufour A, Fung G, Luo H, Overall CM, Jan E. Heterogeneous nuclear ribonucleoprotein M facilitates enterovirus infection. Journal of Virology. PMID 25926642 DOI: 10.1128/JVI.02977-14  0.64
2015 Repnik U, Starr AE, Overall CM, Turk B. Cysteine Cathepsins Activate ELR Chemokines and Inactivate Non-ELR Chemokines. The Journal of Biological Chemistry. 290: 13800-11. PMID 25833952 DOI: 10.1074/jbc.M115.638395  0.64
2015 Zelanis A, Huesgen PF, Oliveira AK, Tashima AK, Serrano SM, Overall CM. Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites. Journal of Proteomics. 113: 260-7. PMID 25452133 DOI: 10.1016/j.jprot.2014.10.002  0.52
2015 Huesgen PF, Lange PF, Rogers LD, Solis N, Eckhard U, Kleifeld O, Goulas T, Gomis-Rüth FX, Overall CM. LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification Nature Methods. 12: 55-58. PMID 25419962 DOI: 10.1038/nmeth.3177  0.64
2015 Fortelny N, Yang S, Pavlidis P, Lange PF, Overall CM. Proteome TopFIND 3.0 with TopFINDer and PathFINDer: database and analysis tools for the association of protein termini to pre- and post-translational events. Nucleic Acids Research. 43: D290-7. PMID 25332401 DOI: 10.1093/nar/gku1012  0.64
2014 Prudova A, Serrano K, Eckhard U, Fortelny N, Devine DV, Overall CM. TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage. Blood. 124: e49-60. PMID 25331112 DOI: 10.1182/blood-2014-04-569640  0.64
2014 Bellac CL, Dufour A, Krisinger MJ, Loonchanta A, Starr AE, Auf dem Keller U, Lange PF, Goebeler V, Kappelhoff R, Butler GS, Burtnick LD, Conway EM, Roberts CR, Overall CM. Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis. Cell Reports. 9: 618-32. PMID 25310974 DOI: 10.1016/j.celrep.2014.09.006  0.64
2014 Barré O, Dufour A, Eckhard U, Kappelhoff R, Béliveau F, Leduc R, Overall CM. Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries Plos One. 9. PMID 25211023 DOI: 10.1371/journal.pone.0105984  0.64
2014 Cruz R, Huesgen P, Riley SP, Wlodawer A, Faro C, Overall CM, Martinez JJ, Simões I. RC1339/APRc from Rickettsia conorii is a novel aspartic protease with properties of retropepsin-like enzymes. Plos Pathogens. 10: e1004324. PMID 25144529 DOI: 10.1371/journal.ppat.1004324  0.64
2014 Fortelny N, Cox JH, Kappelhoff R, Starr AE, Lange PF, Pavlidis P, Overall CM. Network analyses reveal pervasive functional regulation between proteases in the human protease web. Plos Biology. 12: e1001869. PMID 24865846 DOI: 10.1371/journal.pbio.1001869  0.64
2014 Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, ... ... Overall CM, et al. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nature Medicine. 20: 493-502. PMID 24784232 DOI: 10.1038/nm.3508  0.64
2014 Lange PF, Huesgen PF, Nguyen K, Overall CM. Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. Journal of Proteome Research. 13: 2028-44. PMID 24555563 DOI: 10.1021/pr401191w  0.6
2014 Huesgen PF, Lange PF, Overall CM. Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease. Proteomics. Clinical Applications. 8: 338-50. PMID 24497460 DOI: 10.1002/prca.201300104  0.6
2014 Marino G, Huesgen PF, Eckhard U, Overall CM, Schröder WP, Funk C. Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity. The Biochemical Journal. 457: 335-46. PMID 24156403 DOI: 10.1042/BJ20130196  0.64
2014 Eckhard U, Huesgen PF, Brandstetter H, Overall CM. Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen. Journal of Proteomics. 100: 102-14. PMID 24125730 DOI: 10.1016/j.jprot.2013.10.004  0.52
2014 Fahlman RP, Chen W, Overall CM. Absolute proteomic quantification of the activity state of proteases and proteolytic cleavages using proteolytic signature peptides and isobaric tags. Journal of Proteomics. 100: 79-91. PMID 24060996 DOI: 10.1016/j.jprot.2013.09.006  0.64
2014 Borchers CH, Kast J, Foster LJ, Siu KW, Overall CM, Binkowski TA, Hildebrand WH, Scherer A, Mansoor M, Keown PA. The Human Proteome Organization Chromosome 6 Consortium: integrating chromosome-centric and biology/disease driven strategies. Journal of Proteomics. 100: 60-7. PMID 23933161 DOI: 10.1016/j.jprot.2013.08.001  0.64
2013 Huesgen PF, Alami M, Lange PF, Foster LJ, Schröder WP, Overall CM, Green BR. Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids. Plos One. 8: e74483. PMID 24066144 DOI: 10.1371/journal.pone.0074483  0.64
2013 Broder C, Arnold P, Goff SVL, Konerding MA, Bahr K, Müller S, Overall CM, Bond JS, Koudelka T, Tholey A, Hulmes DJS, Moali C, Becker-Pauly C. Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength Proceedings of the National Academy of Sciences of the United States of America. 110: 14219-14224. PMID 23940311 DOI: 10.1073/pnas.1305464110  0.64
2013 Butler GS, Overall CM. Matrix metalloproteinase processing of signaling molecules to regulate inflammation. Periodontology 2000. 63: 123-48. PMID 23931058 DOI: 10.1111/prd.12035  0.36
2013 Rogers LD, Overall CMC. Proteolytic post-translational modification of proteins: Proteomic tools and methodology Molecular and Cellular Proteomics. 12: 3532-3542. PMID 23887885 DOI: 10.1074/mcp.M113.031310  0.64
2013 Solomonson M, Huesgen PF, Wasney GA, Watanabe N, Gruninger RJ, Prehna G, Overall CM, Strynadka NC. Structure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system. The Journal of Biological Chemistry. 288: 17782-90. PMID 23620593 DOI: 10.1074/jbc.M113.462036  0.64
2013 Wilson CH, Indarto D, Doucet A, Pogson LD, Pitman MR, McNicholas K, Menz RI, Overall CM, Abbott CA. Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism. The Journal of Biological Chemistry. 288: 13936-49. PMID 23519473 DOI: 10.1074/jbc.M112.445841  0.64
2013 auf dem Keller U, Prudova A, Eckhard U, Fingleton B, Overall CM. Systems-level analysis of proteolytic events in increased vascular permeability and complement activation in skin inflammation. Science Signaling. 6: rs2. PMID 23322905 DOI: 10.1126/scisignal.2003512  0.64
2013 Lange PF, Overall CM. Protein TAILS: when termini tell tales of proteolysis and function. Current Opinion in Chemical Biology. 17: 73-82. PMID 23298954 DOI: 10.1016/j.cbpa.2012.11.025  0.6
2013 Jefferson T, Auf Dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, ... ... Overall CM, et al. The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10 Cellular and Molecular Life Sciences. 70: 309-333. PMID 22940918 DOI: 10.1007/s00018-012-1106-2  0.64
2012 Patel TR, Butler G, McFarlane A, Xie I, Overall CM, Stetefeld J. Site specific cleavage mediated by MMPs regulates function of agrin. Plos One. 7: e43669. PMID 22984437 DOI: 10.1371/journal.pone.0043669  0.64
2012 Laurent-Matha V, Huesgen PF, Masson O, Derocq D, Prébois C, Gary-Bobo M, Lecaille F, Rebière B, Meurice G, Oréar C, Hollingsworth RE, Abrahamson M, Lalmanach G, Overall CM, Liaudet-Coopman E. Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 5172-81. PMID 22898924 DOI: 10.1096/fj.12-205229  0.64
2012 Starr AE, Bellac CL, Dufour A, Goebeler V, Overall CM. Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities. The Journal of Biological Chemistry. 287: 13382-95. PMID 22367194 DOI: 10.1074/jbc.M111.314179  0.64
2012 Starr AE, Dufour A, Maier J, Overall CM. Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16. The Journal of Biological Chemistry. 287: 5848-60. PMID 22147696 DOI: 10.1074/jbc.M111.314609  0.64
2012 Lange PF, Huesgen PF, Overall CM. TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function. Nucleic Acids Research. 40: D351-61. PMID 22102574 DOI: 10.1093/nar/gkr1025  0.6
2012 Huesgen PF, Overall CM. N- and C-terminal degradomics: new approaches to reveal biological roles for plant proteases from substrate identification. Physiologia Plantarum. 145: 5-17. PMID 22023699 DOI: 10.1111/j.1399-3054.2011.01536.x  0.52
2011 Kleifeld O, Doucet A, Prudova A, auf dem Keller U, Gioia M, Kizhakkedathu JN, Overall CM. Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates. Nature Protocols. 6: 1578-611. PMID 21959240 DOI: 10.1038/nprot.2011.382  0.64
2011 Schilling O, Huesgen PF, Barré O, Overall CM. Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis. Methods in Molecular Biology (Clifton, N.J.). 781: 59-69. PMID 21877277 DOI: 10.1007/978-1-61779-276-2_4  0.52
2011 Lange PF, Overall CM. TopFIND, a knowledgebase linking protein termini with function. Nature Methods. 8: 703-4. PMID 21822272 DOI: 10.1038/nmeth.1669  0.6
2011 Beaudette P, Rossi NA, Huesgen PF, Yu X, Shenoi RA, Doucet A, Overall CM, Kizhakkedathu JN. Development of soluble ester-linked aldehyde polymers for proteomics. Analytical Chemistry. 83: 6500-10. PMID 21774540 DOI: 10.1021/ac200419p  0.52
2011 Ferraro GB, Morrison CJ, Overall CM, Strittmatter SM, Fournier AE. Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage. The Journal of Biological Chemistry. 286: 31418-24. PMID 21768085 DOI: 10.1074/jbc.M111.249169  0.64
2011 Becker-Pauly C, Barré O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM. Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Molecular & Cellular Proteomics : McP. 10: M111.009233. PMID 21693781 DOI: 10.1074/mcp.M111.009233  0.64
2011 Jefferson T, ÄŒauÅ¡ević M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. The Journal of Biological Chemistry. 286: 27741-50. PMID 21646356 DOI: 10.1074/jbc.M111.252718  0.64
2011 Doucet A, Kleifeld O, Kizhakkedathu JN, Overall CM. Identification of proteolytic products and natural protein N-termini by Terminal Amine Isotopic Labeling of Substrates (TAILS). Methods in Molecular Biology (Clifton, N.J.). 753: 273-87. PMID 21604129 DOI: 10.1007/978-1-61779-148-2_18  0.64
2011 Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, Auf dem Keller U, Leung S, Huntsman D, Clarke B, Sutherland BW, Waterhouse D, Bally M, Roskelley C, ... Overall CM, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Research. 71: 3364-76. PMID 21415165 DOI: 10.1158/0008-5472.CAN-10-4261  0.64
2011 Schilling O, Huesgen PF, Barré O, Auf dem Keller U, Overall CM. Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry. Nature Protocols. 6: 111-20. PMID 21212787 DOI: 10.1038/nprot.2010.178  0.52
2011 Li Y, Ting R, Harwig CW, Auf Dem Keller U, Bellac CL, Lange PF, Inkster JAH, Schaffer P, Adam MJ, Ruth TJ, Overall CM, Perrin DM. Towards kit-like 18F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases Medchemcomm. 2: 942-949. DOI: 10.1039/c1md00117e  0.64
2010 auf dem Keller U, Bellac CL, Li Y, Lou Y, Lange PF, Ting R, Harwig C, Kappelhoff R, Dedhar S, Adam MJ, Ruth TJ, Bénard F, Perrin DM, Overall CM. Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer. Cancer Research. 70: 7562-9. PMID 20729277 DOI: 10.1158/0008-5472.CAN-10-1584  0.6
2010 Schilling O, Barré O, Huesgen PF, Overall CM. Proteome-wide analysis of protein carboxy termini: C terminomics. Nature Methods. 7: 508-11. PMID 20526347 DOI: 10.1038/nmeth.1467  0.52
2010 Prudova A, auf dem Keller U, Butler GS, Overall CM. Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics. Molecular & Cellular Proteomics : McP. 9: 894-911. PMID 20305284 DOI: 10.1074/mcp.M000050-MCP201  0.64
2010 auf dem Keller U, Prudova A, Gioia M, Butler GS, Overall CM. A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products. Molecular & Cellular Proteomics : McP. 9: 912-27. PMID 20305283 DOI: 10.1074/mcp.M000032-MCP201  0.64
2010 Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, et al. Stromal regulation of vessel stability by MMP14 and TGFbeta. Disease Models & Mechanisms. 3: 317-32. PMID 20223936 DOI: 10.1242/dmm.003863  0.64
2010 Kleifeld O, Doucet A, auf dem Keller U, Prudova A, Schilling O, Kainthan RK, Starr AE, Foster LJ, Kizhakkedathu JN, Overall CM. Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products. Nature Biotechnology. 28: 281-8. PMID 20208520 DOI: 10.1038/nbt.1611  0.64
2010 Butler GS, Dean RA, Morrison CJ, Overall CM. Identification of cellular MMP substrates using quantitative proteomics: isotope-coded affinity tags (ICAT) and isobaric tags for relative and absolute quantification (iTRAQ). Methods in Molecular Biology (Clifton, N.J.). 622: 451-70. PMID 20135298 DOI: 10.1007/978-1-60327-299-5_26  0.36
2010 Wu Y, Dai J, Schmuckler NG, Bakdash N, Yoder MC, Overall CM, Colman RW. Cleaved high molecular weight kininogen inhibits tube formation of endothelial progenitor cells via suppression of matrix metalloproteinase 2 Journal of Thrombosis and Haemostasis. 8: 185-193. PMID 19874467 DOI: 10.1111/j.1538-7836.2009.03662.x  0.64
2009 Butler GS, Overall CM. Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting. Nature Reviews. Drug Discovery. 8: 935-48. PMID 19949400 DOI: 10.1038/nrd2945  0.36
2009 Butler GS, Overall CM. Updated biological roles for matrix metalloproteinases and new "intracellular" substrates revealed by degradomics. Biochemistry. 48: 10830-45. PMID 19817485 DOI: 10.1021/bi901656f  0.36
2009 Morrison CJ, Butler GS, Rodríguez D, Overall CM. Matrix metalloproteinase proteomics: substrates, targets, and therapy. Current Opinion in Cell Biology. 21: 645-53. PMID 19616423 DOI: 10.1016/  0.36
2009 Hwang Q, Cheifetz S, Overall CM, McCulloch CA, Sodek J. Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation. Bmc Cancer. 9: 121. PMID 19386107 DOI: 10.1186/1471-2407-9-121  1
2009 Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2928-41. PMID 19380511 DOI: 10.1096/fj.08-128819  0.64
2009 Gioia M, Foster LJ, Overall CM. Cell-based identification of natural substrates and cleavage sites for extracellular proteases by SILAC proteomics. Methods in Molecular Biology (Clifton, N.J.). 539: 131-53. PMID 19377966 DOI: 10.1007/978-1-60327-003-8_8  0.64
2009 Butler GS, Dean RA, Smith D, Overall CM. Membrane protease degradomics: proteomic identification and quantification of cell surface protease substrates. Methods in Molecular Biology (Clifton, N.J.). 528: 159-76. PMID 19153692 DOI: 10.1007/978-1-60327-310-7_12  0.36
2008 Dean RA, Cox JH, Bellac CL, Doucet A, Starr AE, Overall CM. Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood. 112: 3455-64. PMID 18660381 DOI: 10.1182/blood-2007-12-129080  0.36
2008 Doucet A, Butler GS, Rodríguez D, Prudova A, Overall CM. Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome. Molecular & Cellular Proteomics : McP. 7: 1925-51. PMID 18596063 DOI: 10.1074/mcp.R800012-MCP200  0.64
2008 Butler GS, Dean RA, Tam EM, Overall CM. Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding. Molecular and Cellular Biology. 28: 4896-914. PMID 18505826 DOI: 10.1128/MCB.01775-07  0.36
2008 Warby SC, Doty CN, Graham RK, Carroll JB, Yang YZ, Singaraja RR, Overall CM, Hayden MR. Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus. Human Molecular Genetics. 17: 2390-404. PMID 18445618 DOI: 10.1093/hmg/ddn139  0.64
2008 Cox JH, Dean RA, Roberts CR, Overall CM. Matrix metalloproteinase processing of CXCL11/I-TAC results in loss of chemoattractant activity and altered glycosaminoglycan binding. The Journal of Biological Chemistry. 283: 19389-99. PMID 18411283 DOI: 10.1074/jbc.M800266200  0.36
2008 Ajami K, Pitman MR, Wilson CH, Park J, Menz RI, Starr AE, Cox JH, Abbott CA, Overall CM, Gorrell MD. Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. Febs Letters. 582: 819-25. PMID 18275857 DOI: 10.1016/j.febslet.2008.02.005  0.64
2008 Ajami K, Pitman MR, Wilson CH, Park J, Menz RI, Starr AE, Cox JH, Abbott CA, Overall CM, Gorrell MD. Corrigendum to "Stromal cell-derived factors 1α and 1β, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8" [FEBS Lett. 582 (2008) 819-825] (DOI:10.1016/j.febslet.2008.02.005) Febs Letters. 582: 1168. DOI: 10.1016/j.febslet.2008.02.066  0.64
2008 Prudova A, Auf Dem Keller U, Overall CM. Identification of protease substrates by mass spectrometry approaches-2 The Cancer Degradome: Proteases and Cancer Biology. 83-100. DOI: 10.1007/978-0-387-69057-5_6  0.64
2008 Kappelhoff R, Wilson CH, Overall CM. The CLIP-CHIP™: A focused oligonucleotide microarray platform for transcriptome analysis of the complete human and murine cancer degradomes The Cancer Degradome: Proteases and Cancer Biology. 17-35. DOI: 10.1007/978-0-387-69057-5_2  0.64
2007 Dean RA, Smith D, Overall CM. Proteomic identification of cellular protease substrates using isobaric tags for relative and absolute quantification (iTRAQ). Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 21.18. PMID 18429318 DOI: 10.1002/0471140864.ps2118s49  0.36
2007 Kim M, Hamilton SE, Guddat LW, Overall CM. Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger. Biochimica Et Biophysica Acta. 1770: 1627-35. PMID 17920199 DOI: 10.1016/j.bbagen.2007.08.003  0.64
2007 Dean RA, Butler GS, Hamma-Kourbali Y, Delbé J, Brigstock DR, Courty J, Overall CM. Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis. Molecular and Cellular Biology. 27: 8454-65. PMID 17908800 DOI: 10.1128/MCB.00821-07  0.36
2007 Wolf K, Wu YI, Liu Y, Geiger J, Tam E, Overall C, Stack MS, Friedl P. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nature Cell Biology. 9: 893-904. PMID 17618273 DOI: 10.1038/ncb1616  0.64
2007 Tester AM, Cox JH, Connor AR, Starr AE, Dean RA, Puente XS, López-Otín C, Overall CM. LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. Plos One. 2: e312. PMID 17375198 DOI: 10.1371/journal.pone.0000312  0.36
2007 Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Moss ML, Fields GB. Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences. Biochemistry. 46: 3724-33. PMID 17338550 DOI: 10.1021/bi062199j  0.64
2007 Dean RA, Overall CM. Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome. Molecular & Cellular Proteomics : McP. 6: 611-23. PMID 17200105 DOI: 10.1074/mcp.M600341-MCP200  0.36
2006 Vergote D, Butler GS, Ooms M, Cox JH, Silva C, Hollenberg MD, Jhamandas JH, Overall CM, Power C. Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 103: 19182-7. PMID 17148615 DOI: 10.1073/pnas.0604678103  0.64
2006 Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Visse R, Nagase H, Fields GB. The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity. The Journal of Biological Chemistry. 281: 38302-13. PMID 17065155 DOI: 10.1074/jbc.M606004200  0.64
2006 Lee H, Overall CM, McCulloch CA, Sodek J. A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis. Molecular Biology of the Cell. 17: 4812-26. PMID 16971509 DOI: 10.1091/mbc.E06-06-0486  1
2006 Overall CM, Dean RA. Degradomics: systems biology of the protease web. Pleiotropic roles of MMPs in cancer. Cancer Metastasis Reviews. 25: 69-75. PMID 16680573 DOI: 10.1007/s10555-006-7890-0  0.36
2006 Overall CM, Kleifeld O. Towards third generation matrix metalloproteinase inhibitors for cancer therapy British Journal of Cancer. 94: 941-946. PMID 16538215 DOI: 10.1038/sj.bjc.6603043  0.64
2006 Overall CM, Kleifeld O. Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nature Reviews. Cancer. 6: 227-39. PMID 16498445 DOI: 10.1038/nrc1821  0.64
2005 Nisato RE, Hosseini G, Sirrenberg C, Butler GS, Crabbe T, Docherty AJ, Wiesner M, Murphy G, Overall CM, Goodman SL, Pepper MS. Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical. Cancer Research. 65: 9377-87. PMID 16230401 DOI: 10.1158/0008-5472.CAN-05-1512  0.64
2005 Nour N, Mayer G, Mort JS, Salvas A, Mbikay M, Morrison CJ, Overall CM, Seidah NG. The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases Molecular Biology of the Cell. 16: 5215-5226. PMID 16135528 DOI: 10.1091/mbc.E05-06-0504  0.64
2005 Maurus R, Begum A, Kuo HH, Racaza A, Numao S, Andersen C, Tams JW, Vind J, Overall CM, Withers SG, Brayer GD. Structural and mechanistic studies of chloride induced activation of human pancreatic alpha-amylase. Protein Science : a Publication of the Protein Society. 14: 743-55. PMID 15722449 DOI: 10.1110/ps.041079305  0.64
2004 El Sayegh TY, Arora PD, Laschinger CA, Lee W, Morrison C, Overall CM, Kapus A, McCulloch CA. Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts. Journal of Cell Science. 117: 5117-31. PMID 15383621 DOI: 10.1242/jcs.01385  0.72
2004 Numao S, Damager I, Li C, Wrodnigg TM, Begum A, Overall CM, Brayer GD, Withers SG. In situ extension as an approach for identifying novel alpha-amylase inhibitors. The Journal of Biological Chemistry. 279: 48282-91. PMID 15304511 DOI: 10.1074/jbc.M406804200  0.64
2004 Tam EM, Moore TR, Butler GS, Overall CM. Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in collagen triple helicase activities. The Journal of Biological Chemistry. 279: 43336-44. PMID 15292230 DOI: 10.1074/jbc.M407186200  0.36
2004 Overall CM, Tam EM, Kappelhoff R, Connor A, Ewart T, Morrison CJ, Puente X, López-Otín C, Seth A. Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors. Biological Chemistry. 385: 493-504. PMID 15255181 DOI: 10.1515/BC.2004.058  0.36
2004 Chan MW, El Sayegh TY, Arora PD, Laschinger CA, Overall CM, Morrison C, McCulloch CA. Regulation of intercellular adhesion strength in fibroblasts. The Journal of Biological Chemistry. 279: 41047-57. PMID 15247242 DOI: 10.1074/jbc.M406631200  0.72
2004 Tam EM, Morrison CJ, Wu YI, Stack MS, Overall CM. Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proceedings of the National Academy of Sciences of the United States of America. 101: 6917-22. PMID 15118097 DOI: 10.1073/pnas.0305862101  0.64
2004 Butler GS, Tam EM, Overall CM. The canonical methionine 392 of matrix metalloproteinase 2 (gelatinase A) is not required for catalytic efficiency or structural integrity: probing the role of the methionine-turn in the metzincin metalloprotease superfamily. The Journal of Biological Chemistry. 279: 15615-20. PMID 14732714 DOI: 10.1074/jbc.M312727200  0.36
2003 Zhang K, McQuibban GA, Silva C, Butler GS, Johnston JB, Holden J, Clark-Lewis I, Overall CM, Power C. HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration. Nature Neuroscience. 6: 1064-71. PMID 14502291 DOI: 10.1038/nn1127  0.64
2002 Radomski A, Jurasz P, Sanders EJ, Overall CM, Bigg HF, Edwards DR, Radomski MW. Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets British Journal of Pharmacology. 137: 1330-1338. PMID 12466243 DOI: 10.1038/sj.bjp.0704936  0.64
2002 Overall CM, McQuibban GA, Clark-Lewis I. Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics. Biological Chemistry. 383: 1059-66. PMID 12437088 DOI: 10.1515/BC.2002.114  0.64
2002 Kai HS, Butler GS, Morrison CJ, King AE, Pelman GR, Overall CM. Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain. The Journal of Biological Chemistry. 277: 48696-707. PMID 12374789 DOI: 10.1074/jbc.M209177200  0.64
2002 McQuibban GA, Gong JH, Wong JP, Wallace JL, Clark-Lewis I, Overall CM. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood. 100: 1160-7. PMID 12149192  0.64
2002 Tam EM, Wu YI, Butler GS, Stack MS, Overall CM. Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage. The Journal of Biological Chemistry. 277: 39005-14. PMID 12145314 DOI: 10.1074/jbc.M206874200  0.64
2002 Rydberg EH, Li C, Maurus R, Overall CM, Brayer GD, Withers SG. Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids. Biochemistry. 41: 4492-502. PMID 11914097 DOI: 10.1021/bi011821z  0.64
2002 Numao S, Maurus R, Sidhu G, Wang Y, Overall CM, Brayer GD, Withers SG. Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase. Biochemistry. 41: 215-25. PMID 11772019 DOI: 10.1021/bi0115636  0.64
2001 McQuibban GA, Butler GS, Gong JH, Bendall L, Power C, Clark-Lewis I, Overall CM. Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. The Journal of Biological Chemistry. 276: 43503-8. PMID 11571304 DOI: 10.1074/jbc.M107736200  0.64
2001 Ellerbroek SM, Wu YI, Overall CM, Stack MS. Functional interplay between type I collagen and cell surface matrix metalloproteinase activity. The Journal of Biological Chemistry. 276: 24833-42. PMID 11331272 DOI: 10.1074/jbc.M005631200  0.64
2001 Kang T, Yi J, Guo A, Wang X, Overall CM, Jiang W, Elde R, Borregaard N, Pei D. Subcellular Distribution and Cytokine- and Chemokine-regulated Secretion of Leukolysin/MT6-MMP/MMP-25 in Neutrophils Journal of Biological Chemistry. 276: 21960-21968. PMID 11282999 DOI: 10.1074/jbc.M007997200  0.64
2000 Overall CM, Tam E, McQuibban GA, Morrison C, Wallon UM, Bigg HF, King AE, Roberts CR. Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation. The Journal of Biological Chemistry. 275: 39497-506. PMID 10991943 DOI: 10.1074/jbc.M005932200  0.64
2000 McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I, Overall CM. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science (New York, N.Y.). 289: 1202-6. PMID 10947989 DOI: 10.1126/science.289.5482.1202  0.64
2000 Brayer GD, Sidhu G, Maurus R, Rydberg EH, Braun C, Wang Y, Nguyen NT, Overall CM, Withers SG. Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry. 39: 4778-91. PMID 10769135 DOI: 10.1021/bi9921182  0.64
1999 Mancini S, Romanelli R, Laschinger CA, Overall CM, Sodek J, McCulloch CA. Assessment of a novel screening test for neutrophil collagenase activity in the diagnosis of periodontal diseases. Journal of Periodontology. 70: 1292-302. PMID 10588492 DOI: 10.1902/jop.1999.70.11.1292  1
1999 Overall CM, King AE, Bigg HF, McQuibban A, Atherstone J, Sam DK, Ong AD, Lau TT, Wallon UM, DeClerck YA, Tam E. Identification of the TIMP-2 binding site on the gelatinase A hemopexin C-domain by site-directed mutagenesis and the yeast two-hybrid system. Annals of the New York Academy of Sciences. 878: 747-53. PMID 10415826 DOI: 10.1111/j.1749-6632.1999.tb07780.x  0.64
1999 Romanelli R, Mancini S, Laschinger C, Overall CM, Sodek J, McCulloch CA. Activation of neutrophil collagenase in periodontitis. Infection and Immunity. 67: 2319-26. PMID 10225890 DOI: 10.1128/IAI.67.5.2319-2326.1999  1
1999 Rydberg EH, Sidhu G, Vo HC, Hewitt J, Côte HC, Wang Y, Numao S, MacGillivray RT, Overall CM, Brayer GD, Withers SG. Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris. Protein Science : a Publication of the Protein Society. 8: 635-43. PMID 10091666 DOI: 10.1110/ps.8.3.635  0.64
1999 Overall CM, King AE, Sam DK, Ong AD, Lau TT, Wallon UM, DeClerck YA, Atherstone J. Identification of the tissue inhibitor of metalloproteinases-2 (TIMP-2) binding site on the hemopexin carboxyl domain of human gelatinase A by site-directed mutagenesis. The hierarchical role in binding TIMP-2 of the unique cationic clusters of hemopexin modules III and IV. The Journal of Biological Chemistry. 274: 4421-9. PMID 9933646 DOI: 10.1074/jbc.274.7.4421  0.64
1998 Sutinen M, Kainulainen T, Hurskainen T, Vesterlund E, Alexander JP, Overall CM, Sorsa T, Salo T. Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis British Journal of Cancer. 77: 2239-2245. PMID 9649139 DOI: 10.1038/bjc.1998.372  0.64
1997 Maurus R, Overall CM, Bogumil R, Luo Y, Mauk AG, Smith M, Brayer GD. A myoglobin variant with a polar substitution in a conserved hydrophobic cluster in the heme binding pocket. Biochimica Et Biophysica Acta. 1341: 1-13. PMID 9300804  0.32
1992 Sodek J, Overall CM. Matrix metalloproteinases in periodontal tissue remodelling. Matrix (Stuttgart, Germany). Supplement. 1: 352-62. PMID 1480060  1
1992 Overall CM, Sodek J. Reciprocal regulation of collagenase, 72 kDa-gelatinase, and TIMP gene expression and protein synthesis in human fibroblasts induced by concanavalin A. Matrix (Stuttgart, Germany). Supplement. 1: 209-11. PMID 1480028  1
1991 Wrana JL, Kubota T, Zhang Q, Overall CM, Aubin JE, Butler WT, Sodek J. Regulation of transformation-sensitive secreted phosphoprotein (SPPI/osteopontin) expression by transforming growth factor-beta. Comparisons with expression of SPARC (secreted acidic cysteine-rich protein). The Biochemical Journal. 273: 523-31. PMID 1996953  0.64
1991 Kasugai S, Zhang Q, Overall CM, Wrana JL, Butler WT, Sodek J. Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter. Bone and Mineral. 13: 235-50. PMID 1863811 DOI: 10.1016/0169-6009(91)90071-7  1
1991 Overall CM, Wrana JL, Sodek J. Induction of formative and resorptive cellular phenotypes in human gingival fibroblasts by TGF-beta 1 and concanavalin A: regulation of matrix metalloproteinases and TIMP. Journal of Periodontal Research. 26: 279-82. PMID 1831853 DOI: 10.1111/j.1600-0765.1991.tb01658.x  1
1991 Wrana JL, Overall CM, Sodek J. Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen. European Journal of Biochemistry. 197: 519-28. PMID 1709099 DOI: 10.1111/j.1432-1033.1991.tb15940.x  1
1991 Lee W, Aitken S, Kulkarni G, Birek P, Overall CM, Sodek J, McCulloch CA. Collagenase activity in recurrent periodontitis: relationship to disease progression and doxycycline therapy. Journal of Periodontal Research. 26: 479-85. PMID 1662266 DOI: 10.1111/j.1600-0765.1991.tb01798.x  1
1991 Overall CM, Sodek J, McCulloch CA, Birek P. Evidence for polymorphonuclear leukocyte collagenase and 92-kilodalton gelatinase in gingival crevicular fluid. Infection and Immunity. 59: 4687-92. PMID 1657787 DOI: 10.1128/IAI.59.12.4687-4692.1991  1
1991 Overall CM, Wrana JL, Sodek J. Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression. The Journal of Biological Chemistry. 266: 14064-71. PMID 1649834  1
1990 Overall CM, Sodek J. Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases. The Journal of Biological Chemistry. 265: 21141-51. PMID 2174435  1
1990 Gangbar S, Overall CM, McCulloch CA, Sodek J. Identification of polymorphonuclear leukocyte collagenase and gelatinase activities in mouthrinse samples: correlation with periodontal disease activity in adult and juvenile periodontitis. Journal of Periodontal Research. 25: 257-67. PMID 2170617 DOI: 10.1111/j.1600-0765.1990.tb00914.x  1
1989 Overall CM, Wrana JL, Sodek J. Transforming growth factor-beta regulation of collagenase, 72 kDa-progelatinase, TIMP and PAI-1 expression in rat bone cell populations and human fibroblasts. Connective Tissue Research. 20: 289-94. PMID 2558843 DOI: 10.3109/03008208909023899  1
1989 Overall CM, Wrana JL, Sodek J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. The Journal of Biological Chemistry. 264: 1860-9. PMID 2536374  1
1989 Khokha R, Waterhouse P, Yagel S, Lala PK, Overall CM, Norton G, Denhardt DT. Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells Science. 243: 947-950. PMID 2465572 DOI: 10.1126/science.2465572  0.64
1988 Drouin L, Overall CM, Sodek J. Identification of matrix metalloendoproteinase inhibitor (TIMP) in human parotid and submandibular saliva: partial purification and characterization. Journal of Periodontal Research. 23: 370-7. PMID 2851041 DOI: 10.1111/j.1600-0765.1988.tb01615.x  1
1988 Otsuka K, Pitaru S, Overall CM, Aubin JE, Sodek J. Biochemical comparison of fibroblast populations from different periodontal tissues: characterization of matrix protein and collagenolytic enzyme synthesis. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 66: 167-76. PMID 2838055  0.64
1987 Overall CM, Sodek J. Initial characterization of a neutral metalloproteinase, active on native 3/4-collagen fragments, synthesized by ROS 17/2.8 osteoblastic cells, periodontal fibroblasts, and identified in gingival crevicular fluid. Journal of Dental Research. 66: 1271-82. PMID 3040831 DOI: 10.1177/00220345870660071201  1
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