Raghavendra Mirmira - Publications

University of Virginia, Charlottesville, VA 
Molecular Biology

166 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ibrahim S, Johnson M, Stephens CH, Xu J, Moore R, Mariani A, Contreras C, Syed F, Mirmira RG, Anderson RM, Sims EK. β-Cell pre-miR-21 Induces Dysfunction and Loss of Cellular Identity by Targeting Transforming Growth Factor Beta 2 (Tgfb2) and Smad Family Member 2 (Smad2) mRNAs. Molecular Metabolism. 101289. PMID 34246804 DOI: 10.1016/j.molmet.2021.101289  0.01
2021 Adams MT, Dwulet JM, Briggs JK, Reissaus CA, Jin E, Szulczewski JM, Lyman MR, Sdao SM, Kravets V, Nimkulrat SD, Ponik SM, Merrins MJ, Mirmira RG, Linnemann AK, Benninger RK, et al. Reduced synchroneity of intra-islet Ca oscillations in -deficient β cells. Elife. 10. PMID 34231467 DOI: 10.7554/eLife.61308  0.01
2021 Gitelman SE, Bundy BN, Ferrannini E, Lim N, Blanchfield JL, DiMeglio LA, Felner EI, Gaglia JL, Gottlieb PA, Long SA, Mari A, Mirmira RG, Raskin P, Sanda S, Tsalikian E, et al. Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. The Lancet. Diabetes & Endocrinology. PMID 34214479 DOI: 10.1016/S2213-8587(21)00139-X  0.01
2021 Kulkarni A, Pineros AR, Walsh MA, Casimiro I, Ibrahim S, Hernandez-Perez M, Orr KS, Glenn L, Nadler JL, Morris MA, Tersey SA, Mirmira RG, Anderson RM. 12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes. Jci Insight. PMID 34128835 DOI: 10.1172/jci.insight.147812  0.01
2021 Kulkarni A, Nadler JL, Mirmira RG, Casimiro I. Regulation of Tissue Inflammation by 12-Lipoxygenases. Biomolecules. 11. PMID 34064822 DOI: 10.3390/biom11050717  0.01
2021 Padgett LR, Robertson MA, Anderson-Baucum EK, Connors CT, Wu W, Mirmira RG, Mastracci TL. Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21473. PMID 33811703 DOI: 10.1096/fj.201903177R  0.01
2021 Arosemena M, Meah FA, Mather KJ, Tersey SA, Mirmira RG. Cell-Free DNA Fragments as Biomarkers of Islet β-Cell Death in Obesity and Type 2 Diabetes. International Journal of Molecular Sciences. 22. PMID 33670079 DOI: 10.3390/ijms22042151  0.01
2021 Maguire OA, Ackerman SE, Szwed SK, Maganti AV, Marchildon F, Huang X, Kramer DJ, Rosas-Villegas A, Gelfer RG, Turner LE, Ceballos V, Hejazi A, Samborska B, Rahbani JF, Dykstra CB, ... ... Mirmira RG, et al. Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metabolism. PMID 33596409 DOI: 10.1016/j.cmet.2021.01.018  0.01
2021 López de la Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián M, Sialana FJ, Castilla L, Bae N, Lobo C, Peñalver A, García-Frutos M, Carro D, Enrique V, Paz JC, Mirmira RG, et al. Author Correction: Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation. Scientific Reports. 11: 249. PMID 33397990 DOI: 10.1038/s41598-020-80651-0  0.01
2020 Piñeros AR, Gao H, Wu W, Liu Y, Tersey SA, Mirmira RG. Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention. Metabolites. 10. PMID 33353164 DOI: 10.3390/metabo10120513  0.01
2020 Gobert AP, Finley JL, Latour YL, Asim M, Smith TM, Verriere TG, Barry DP, Allaman MM, Delagado AG, Rose KL, Calcutt MW, Schey KL, Sierra JC, Piazuelo MB, Mirmira RG, et al. Hypusination Orchestrates the Antimicrobial Response of Macrophages. Cell Reports. 33: 108510. PMID 33326776 DOI: 10.1016/j.celrep.2020.108510  0.01
2020 Casimiro I, Stull ND, Tersey SA, Mirmira RG. Phenotypic sexual dimorphism in response to dietary fat manipulation in C57BL/6J mice. Journal of Diabetes and Its Complications. 107795. PMID 33308894 DOI: 10.1016/j.jdiacomp.2020.107795  0.01
2020 Witkowski P, Philipson L, Kaufman DB, Ratner L, Abouljoud MS, Bellin M, Buse J, Kandeel F, Stock P, Mulligan D, Markmann JF, Kozlowski T, Andreoni K, Alejandro R, Baidal D, ... ... Mirmira RG, et al. The Demise of Islet Allotransplantation in the US: A Call for an Urgent Regulatory Update The "ISLETS FOR US" Collaborative. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 33251712 DOI: 10.1111/ajt.16397  1
2020 Nakayasu ES, Metz TO, Mirmira RG. Probing islet stress in type 1 diabetes. Aging. 12: 18795-18796. PMID 33048839 DOI: 10.18632/aging.104157  0.01
2020 Sims EK, Mirmira RG, Evans-Molina C. The role of beta-cell dysfunction in early type 1 diabetes. Current Opinion in Endocrinology, Diabetes, and Obesity. 27: 215-224. PMID 32618633 DOI: 10.1097/Med.0000000000000548  1
2020 Stephens CH, Morrison RA, McLaughlin M, Orr K, Tersey SA, Scott-Moncrieff JC, Mirmira RG, Considine RV, Voytik-Harbin S. Oligomeric collagen as an encapsulation material for islet/β cell replacement: Effect of islet source, dose, implant site, and administration format. American Journal of Physiology. Endocrinology and Metabolism. PMID 32543944 DOI: 10.1152/Ajpendo.00066.2020  0.01
2020 Coomans de Brachène A, Castela A, Op de Beeck A, Mirmira RG, Marselli L, Marchetti P, Masse C, Miao W, Leit S, Evans-Molina C, Eizirik DL. Pre-clinical evaluation of TYK2 inhibitors for human beta cell protection in type 1 diabetes. Diabetes, Obesity & Metabolism. PMID 32476252 DOI: 10.1111/dom.14104  1
2020 Ibrahim S, Harris-Kawano A, Haider I, Mirmira RG, Sims EK, Anderson RM. A Novel Cre-Enabled Tetracycline Inducible transgenic system for tissue specific cytokine expression in the zebrafish: CETI-PIC3. Disease Models & Mechanisms. PMID 32457041 DOI: 10.1242/dmm.042556  0.01
2020 Lemmerman LR, Das D, Higuita-Castro N, Mirmira RG, Gallego-Perez D. Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment. Trends in Endocrinology and Metabolism: Tem. 31: 448-458. PMID 32396845 DOI: 10.1016/j.tem.2020.02.001  0.01
2020 Kaiser UB, Mirmira RG, Stewart PM. Our Response to COVID-19 as Endocrinologists and Diabetologists. The Journal of Clinical Endocrinology and Metabolism. 105. PMID 32232480 DOI: 10.1210/Clinem/Dgaa148  0.01
2020 Mastracci TL, Colvin SC, Padgett LR, Mirmira RG. Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes. Plos One. 15: e0230627. PMID 32208453 DOI: 10.1371/journal.pone.0230627  0.01
2020 Reissaus CA, Day KH, Mirmira RG, Dunn KW, Pavalko FM, Day RN. PIE-FLIM Measurements of Two Different FRET-Based Biosensor Activities in the Same Living Cells. Biophysical Journal. PMID 32191861 DOI: 10.1016/J.Bpj.2020.03.003  0.01
2020 López de la Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián M, Sialana FJ, Castilla L, Bae N, Lobo C, Peñalver A, García-Frutos M, Carro D, Enrique V, Paz JC, Mirmira RG, et al. Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation. Scientific Reports. 10: 2259. PMID 32042057 DOI: 10.1038/s41598-020-58264-4  0.01
2020 Nakayasu ES, Syed F, Tersey SA, Gritsenko MA, Mitchell HD, Chan CY, Dirice E, Turatsinze JV, Cui Y, Kulkarni RN, Eizirik DL, Qian WJ, Webb-Robertson BM, Evans-Molina C, Mirmira RG, et al. Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention. Cell Metabolism. PMID 31928885 DOI: 10.1016/J.Cmet.2019.12.005  1
2020 Speake C, Ylescupidez A, Neiman D, Shemer R, Glaser B, Tersey SA, Usmani-Brown S, Clark P, Wilhelm JJ, Bellin MD, Herold KC, Mirmira RG, Dor Y, Evans-Molina C. Circulating unmethylated insulin DNA as a biomarker of human beta cell death: a multi-laboratory assay comparison. The Journal of Clinical Endocrinology and Metabolism. PMID 31913467 DOI: 10.1210/Clinem/Dgaa008  1
2020 Pineros A, Kulkarni A, Hernandez-Perez M, Orr K, Glenn L, Reissaus CA, Gannon M, Mcduffie MJ, Nadler J, Morris MA, Mirmira R, Tersey SA. 85-OR: Islet-Autonomous Inflammatory Signaling Propagates Autoimmunity and Promotes Diabetes in Nonobese Diabetic Mice Diabetes. 69. DOI: 10.2337/Db20-85-Or  0.01
2020 Syed F, Maier BF, Anderson-Baucum E, Mastracci TL, Evans-Molina C, Mirmira R. 82-OR: Exosomes from Human ß-Cells Incorporate Stress Granule Components and May Serve as Biomarkers of ß-Cell Stress in Type 1 Diabetes Diabetes. 69. DOI: 10.2337/Db20-82-Or  1
2020 Wu W, Syed F, Simpson E, Lee C, Eizirik DL, Mirmira R, Liu Y, Evans-Molina C. 81-OR: The Impact of Proinflammatory Cytokines on Human Pancreatic Islet Alternative Splicing Patterns Diabetes. 69. DOI: 10.2337/Db20-81-Or  1
2020 Ibrahim S, Stephens C, Moore RE, Mirmira R, Sims EK. 80-OR: ß-Cell Hif1a-miR-21 Signaling Exacerbates ß-Cell Dysfunction Occurring during Diabetogenic Stress Diabetes. 69. DOI: 10.2337/Db20-80-Or  0.01
2020 Pineros A, Kulkarni A, Orr K, Glenn L, Reissaus CA, Hernandez-Perez M, Mcduffie MJ, Nadler J, Morris MA, Mirmira R, Tersey SA. 288-OR: Myeloid-Specific Deletion of Alox15 Decreases Pancreatic Inflammation and Protects from Spontaneous Diabetes Development in Nonobese Diabetic (NOD) Mice Diabetes. 69. DOI: 10.2337/Db20-288-Or  0.01
2020 Kulkarni A, Pineros A, Ibrahim S, Hernandez-Perez M, Tersey SA, Mirmira R, Anderson RM. 2128-P: 12/15-Lipoxygenase Regulates Macrophage Migration during Islet Inflammation Diabetes. 69. DOI: 10.2337/Db20-2128-P  0.01
2020 Hernandez-Perez M, Haider I, Anderson RM, Tersey SA, Mirmira R. 2111-P: Role of G-Protein Coupled Receptor 31 (GPR31) in ß-Cell Health and Disease Diabetes. 69. DOI: 10.2337/Db20-2111-P  0.01
2020 Syed F, Krishnan P, Restrepo I, Mirmira R, Evans-Molina C. 2034-P: ß Cell miRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and Risk Diabetes. 69. DOI: 10.2337/Db20-2034-P  1
2020 Neyman A, Moors K, Evans-Molina C, Dimeglio L, Mirmira R, Mather KJ, Hannon TS, Sims EK. 1616-P: Stimulated ß-Cell Response Is Unaltered in Adult Autoantibody (AB) Negative Relatives of Individuals with Type 1 Diabetes (T1D) Diabetes. 69. DOI: 10.2337/Db20-1616-P  1
2020 Lemmerman LR, Rincon-Benavides MA, Tersey SA, Blackstone BN, Powell HM, Higuita-Castro N, Mirmira R, Gallego-Perez D. 117-LB: Nonviral Direct Reprogramming of Human Skin Fibroblasts into Hormone-Expressing ß-Like Cell Clusters Diabetes. 69. DOI: 10.2337/Db20-117-Lb  0.01
2019 Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, ... ... Mirmira RG, et al. Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis. Science Signaling. 12. PMID 31796630 DOI: 10.1126/Scisignal.Aax0715  1
2019 Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C. Abnormalities in proinsulin processing in islets from individuals with longstanding T1D. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 31442418 DOI: 10.1016/J.Trsl.2019.08.001  1
2019 Farr RJ, Wong WKM, Maynard CL, Tersey SA, Mirmira RG, Hardikar AA, Joglekar MV. Comparative analysis of diagnostic platforms for measurement of differentially methylated insulin DNA. Journal of Biological Methods. 6. PMID 31328130 DOI: 10.14440/jbm.2019.280  0.01
2019 Nakayasu ES, Qian WJ, Evans-Molina C, Mirmira RG, Eizirik DL, Metz TO. The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes. Expert Review of Proteomics. 1-14. PMID 31232620 DOI: 10.1080/14789450.2019.1634548  1
2019 Reissaus CA, Piñeros AR, Twigg AN, Orr KS, Conteh AM, Martinez MM, Kamocka MM, Day RN, Tersey SA, Mirmira RG, Dunn KW, Linnemann AK. A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo. Scientific Reports. 9: 8449. PMID 31186447 DOI: 10.1038/S41598-019-44777-0  0.01
2019 Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, et al. Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264. Diabetes Care. 42: e85-e86. PMID 31010952 DOI: 10.2337/Dci19-0012  1
2019 Conteh AM, Reissaus CA, Hernandez-Perez M, Nakshatri S, Anderson RM, Mirmira RG, Tersey SA, Linnemann AK. Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in islet β-cells. The Journal of Biological Chemistry. PMID 30792307 DOI: 10.1074/jbc.RA118.007102  0.04
2019 Imam S, Prathibha R, Dar P, Almotah K, Al-Khudhair A, Hasan SA, Salim N, Jilani TN, Mirmira RG, Jaume JC. eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes. Scientific Reports. 9: 1533. PMID 30733517 DOI: 10.1038/s41598-018-38341-5  0.01
2019 Ganapathi M, Padgett LR, Yamada K, Devinsky O, Willaert R, Person R, Au PB, Tagoe J, McDonald M, Karlowicz D, Wolf B, Lee J, Shen Y, Okur V, Deng L, ... ... Mirmira RG, et al. Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder. American Journal of Human Genetics. PMID 30661771 DOI: 10.1016/j.ajhg.2018.12.017  0.01
2019 Ocaña GJ, Sims EK, Watkins RA, Ragg S, Mather KJ, Oram RA, Mirmira RG, DiMeglio LA, Blum JS, Evans-Molina C. Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes. Plos One. 14: e0208456. PMID 30629603 DOI: 10.1371/Journal.Pone.0208456  1
2018 Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care. PMID 30530850 DOI: 10.2337/Dc17-2625  1
2018 Kan B, Michalski C, Fu H, Au HHT, Lee K, Marchant EA, Cheng MF, Anderson-Baucum E, Aharoni-Simon M, Tilley P, Mirmira RG, Ross CJ, Luciani DS, Jan E, Lavoie PM. Cellular metabolism constrains innate immune responses in early human ontogeny. Nature Communications. 9: 4822. PMID 30446641 DOI: 10.1038/S41467-018-07215-9  0.01
2018 Dobrian AD, Morris MA, Taylor-Fishwick DA, Holman TR, Imai Y, Mirmira RG, Nadler JL. Role of the 12-Lipoxygenase Pathway in Diabetes Pathogenesis and Complications. Pharmacology & Therapeutics. PMID 30347209 DOI: 10.1016/j.pharmthera.2018.10.010  0.01
2018 Roels S, Costa OR, Tersey SA, Stangé G, De Smet D, Balti EV, Gillard P, Keymeulen B, Ling Z, Pipeleers DG, Gorus FK, Mirmira RG, Martens GA. Combined Analysis of GAD65, miR-375 and Unmethylated Insulin DNA Following Islet Transplantation in T1D Patients. The Journal of Clinical Endocrinology and Metabolism. PMID 30203041 DOI: 10.1210/jc.2017-02520  0.01
2018 Sims EK, Evans-Molina C, Tersey SA, Eizirik DL, Mirmira RG. Biomarkers of islet beta cell stress and death in type 1 diabetes. Diabetologia. PMID 30112687 DOI: 10.1007/S00125-018-4712-1  1
2018 Neyman A, Nelson J, Tersey S, Mirmira RG, Evans-Molina C, Sims EK. Persistent Elevations in Circulating INS DNA Among Subjects with Longstanding Type 1 Diabetes. Diabetes, Obesity & Metabolism. PMID 30073765 DOI: 10.1111/dom.13489  1
2018 Kjalarsdottir L, Tersey SA, Vishwanath M, Chuang JC, Posner BA, Mirmira RG, Repa JJ. 1,25-Dihydroxyvitamin D enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor. The Journal of Steroid Biochemistry and Molecular Biology. PMID 30071248 DOI: 10.1016/j.jsbmb.2018.07.004  0.01
2018 Stephens CH, Orr KS, Acton AJ, Tersey SA, Mirmira RG, Considine RV, Voytik-Harbin SL. In-situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo. American Journal of Physiology. Endocrinology and Metabolism. PMID 29894201 DOI: 10.1152/ajpendo.00073.2018  0.01
2018 Tersey SA, Levasseur EM, Syed F, Farb TB, Orr KS, Nelson JB, Shaw JL, Bokvist K, Mather KJ, Mirmira RG. Episodic β-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800150RR. PMID 29812970 DOI: 10.1096/fj.201800150RR  0.01
2018 Sims EK, Park G, Mather KJ, Mirmira RG, Liu Z, Gupta SK. Immune reconstitution in ART treated, but not untreated HIV infection, is associated with abnormal beta cell function. Plos One. 13: e0197080. PMID 29795574 DOI: 10.1371/Journal.Pone.0197080  0.01
2018 Kulkarni AA, Conteh AM, Sorrell CA, Mirmira A, Tersey SA, Mirmira RG, Linnemann AK, Anderson RM. An Zebrafish Model for Interrogating ROS-Mediated Pancreatic -Cell Injury, Response, and Prevention. Oxidative Medicine and Cellular Longevity. 2018: 1324739. PMID 29785241 DOI: 10.1155/2018/1324739  0.01
2018 Marasco MR, Conteh AM, Reissaus CA, Cupit V JE, Appleman EM, Mirmira RG, Linnemann AK. Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response. Diabetes. PMID 29784660 DOI: 10.2337/db17-1280  0.01
2018 Beli E, Yan Y, Moldovan L, Vieira CP, Gao R, Duan Y, Prasad R, Bhatwadekar A, White FA, Townsend S, Chan L, Ryan CN, Morton D, Moldovan EG, Chu FI, ... ... Mirmira RG, et al. Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice. Diabetes. PMID 29712667 DOI: 10.2337/Db18-0158  1
2018 Mastracci TL, Turatsinze JV, Book BK, Restrepo IA, Pugia MJ, Wiebke EA, Pescovitz MD, Eizirik DL, Mirmira RG. Distinct Gene Expression Pathways in Islets from Individuals with Short- and Long-Duration Type 1 Diabetes. Diabetes, Obesity & Metabolism. PMID 29569324 DOI: 10.1111/dom.13298  0.01
2018 Simons ZB, Morgan RC, Rose L, Nelson JB, Tersey SA, Mirmira RG. Hypoglycemia in a Patient With a Polyhormonal Pancreatic Neuroendocrine Tumor With Evidence of Endocrine Progenitors. Journal of the Endocrine Society. 2: 172-177. PMID 29568813 DOI: 10.1210/js.2017-00409  0.01
2018 Coomans de Brachène A, Dos Santos RS, Marroqui L, Colli ML, Marselli L, Mirmira RG, Marchetti P, Eizirik DL. IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells. Diabetologia. PMID 29305625 DOI: 10.1007/s00125-017-4536-4  0.01
2018 Mulukutla SN, Tersey SA, Hampe CS, Mirmira RG, Balasubramanyam A. Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes. Journal of Diabetes and Its Complications. 32: 193-195. PMID 29175121 DOI: 10.1016/j.jdiacomp.2017.10.013  0.01
2017 Anjanappa M, Hao Y, Simpson ER, Bhat-Nakshatri P, Nelson JB, Tersey SA, Mirmira RG, Cohen-Gadol AA, Saadatzadeh MR, Li L, Fang F, Nephew KP, Miller KD, Liu Y, Nakshatri H. A system for detecting high impact-low frequency mutations in primary tumors and metastases. Oncogene. PMID 28892047 DOI: 10.1038/onc.2017.322  0.01
2017 Samala N, Tersey SA, Chalasani N, Anderson RM, Mirmira RG. Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase. Journal of Diabetes and Its Complications. PMID 28886991 DOI: 10.1016/j.jdiacomp.2017.07.014  0.01
2017 Nyalwidhe JO, Grzesik WJ, Burch TC, Semeraro ML, Waseem T, Gerling IC, Mirmira RG, Morris MA, Nadler JL. Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes. Plos One. 12: e0183908. PMID 28877242 DOI: 10.1371/journal.pone.0183908  0.01
2017 Hernandez-Perez M, Chopra G, Fine J, Conteh AM, Anderson RM, Linnemann AK, Benjamin C, Nelson JB, Benninger KS, Nadler JL, Maloney DJ, Tersey SA, Mirmira RG. Inhibition of 12/15-Lipoxygenase Protects Against β Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes. Diabetes. PMID 28842399 DOI: 10.2337/Db17-0215  0.01
2017 Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Rüegg MA, Hall MN, Bernal-Mizrachi E. Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing. Nature Communications. 8: 16014. PMID 28699639 DOI: 10.1038/Ncomms16014  0.01
2017 Hatanaka M, Anderson-Baucum E, Lakhter A, Kono T, Maier B, Tersey SA, Tanizawa Y, Evans-Molina C, Mirmira RG, Sims EK. Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation. Scientific Reports. 7: 3758. PMID 28630491 DOI: 10.1038/S41598-017-03869-5  1
2017 Ma K, Park SH, Lindsey G, Laura J, Tatvam B, Weaver JR, Taylor-Fishwick DA, Luci DK, Maloney DJ, Mirmira RG, Imai Y, Nadler JL. 12-lipoxygenase inhibitor improves functions of cytokine-treated human islets and type 2 diabetic islets The Journal of Clinical Endocrinology and Metabolism. PMID 28609824 DOI: 10.1210/jc.2017-00267  0.01
2016 Tersey SA, Nelson JB, Fisher MM, Mirmira RG. Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death. Journal of Visualized Experiments : Jove. PMID 28060259 DOI: 10.3791/54838  0.04
2016 Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN. Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Scientific Reports. 6: 34969. PMID 27721427 DOI: 10.1038/srep34969  0.01
2016 Maganti AV, Tersey SA, Syed F, Nelson JB, Colvin SC, Maier B, Mirmira RG. Peroxisome Proliferator-Activated Receptor-γ Activation Augments the β Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-Obese Diabetic Mice. The Journal of Biological Chemistry. PMID 27613867 DOI: 10.1074/jbc.M116.741694  1
2016 Mirmira RG, Sims EK, Syed F, Evans-Molina C. Biomarkers of β-Cell Stress and Death in Type 1 Diabetes. Current Diabetes Reports. 16: 95. PMID 27541297 DOI: 10.1007/S11892-016-0783-X  1
2016 Sims EK, Chaudhry Z, Watkins R, Syed F, Blum J, Ouyang F, Perkins SM, Mirmira RG, Sosenko J, DiMeglio LA, Evans-Molina C. Elevations in the Fasting Serum Proinsulin-to-C-Peptide Ratio Precede the Onset of Type 1 Diabetes. Diabetes Care. PMID 27385327 DOI: 10.2337/Dc15-2849  1
2016 Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN. IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Scientific Reports. 6: 28177. PMID 27378176 DOI: 10.1038/srep28177  0.01
2016 Villa SR, Priyadarshini M, Fuller MH, Bhardwaj T, Brodsky MR, Angueira AR, Mosser RE, Carboneau BA, Tersey SA, Mancebo H, Gilchrist A, Mirmira RG, Gannon M, Layden BT. Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival. Scientific Reports. 6: 28159. PMID 27324831 DOI: 10.1038/Srep28159  1
2015 Shih H, Mirmira RG, Lin CC. Visible light-initiated interfacial thiol-norbornene photopolymerization for forming islet surface conformal coating. Journal of Materials Chemistry. B, Materials For Biology and Medicine. 3: 170-175. PMID 26509035 DOI: 10.1039/C4TB01593B  0.01
2015 Xiong X, Wang G, Tao R, Wu P, Kono T, Li K, Ding WX, Tong X, Tersey SA, Harris RA, Mirmira RG, Evans-Molina C, Dong XC. Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Diabetologia. PMID 26471901 DOI: 10.1007/S00125-015-3778-2  1
2015 Mirmira RG. Editorial: Lessons From the Classic Scientific Literature. Molecular Endocrinology (Baltimore, Md.). 29: 1385-7. PMID 26426488 DOI: 10.1210/me.2015-1231  0.01
2015 Watkins RA, Evans-Molina C, Terrell JK, Day KH, Guindon L, Restrepo IA, Mirmira RG, Blum JS, DiMeglio LA. Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 26397425 DOI: 10.1016/J.Trsl.2015.08.010  1
2015 Mastracci TL, Robertson MA, Mirmira RG, Anderson RM. Polyamine biosynthesis is critical for growth and differentiation of the pancreas. Scientific Reports. 5: 13269. PMID 26299433 DOI: 10.1038/srep13269  1
2015 Fisher MM, Watkins RA, Blum J, Evans-Molina C, Chalasani N, DiMeglio LA, Mather KJ, Tersey SA, Mirmira RG. Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes. Diabetes. 64: 3867-72. PMID 26216854 DOI: 10.2337/Db15-0430  1
2015 Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT. An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion. Molecular Endocrinology (Baltimore, Md.). 29: 1055-66. PMID 26075576 DOI: 10.1210/Me.2015-1007  1
2015 Fujimaki K, Ogihara T, Morris DL, Oda H, Iida H, Fujitani Y, Mirmira RG, Evans-Molina C, Watada H. Set7/9 Regulates Cytokine-Induced Expression of Inducible Nitric Oxide Synthase Through Methylation of Lysine 4 at Histone 3 in the Islet β cell. The Journal of Biological Chemistry. PMID 25995453 DOI: 10.1074/Jbc.M115.661777  1
2015 Tersey SA, Bolanis E, Holman TR, Maloney DJ, Nadler JL, Mirmira RG. Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes. Molecular Endocrinology (Baltimore, Md.). 29: 791-800. PMID 25803446 DOI: 10.1210/me.2015-1041  0.01
2015 Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG. Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9. The Journal of Biological Chemistry. 290: 9812-22. PMID 25713082 DOI: 10.1074/Jbc.M114.616219  1
2015 Filgueiras LR, Brandt SL, Wang S, Wang Z, Morris DL, Evans-Molina C, Mirmira RG, Jancar S, Serezani CH. Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes. Science Signaling. 8: ra10. PMID 25628460 DOI: 10.1126/Scisignal.2005568  1
2015 Tersey SA, Bolanis E, Holman TR, Maloney DJ, Nadler JL, Mirmira RG. Minireview: 12-lipoxygenase and islet β-cell dysfunction in diabetes Molecular Endocrinology. 29: 791-800. DOI: 10.1210/me.2015-1041  1
2015 Shih H, Mirmira RG, Lin CC. Visible light-initiated interfacial thiol-norbornene photopolymerization for forming an islet surface conformal coating Journal of Materials Chemistry B. 3: 170-175. DOI: 10.1039/c4tb01593b  1
2014 Maganti A, Evans-Molina C, Mirmira R. From immunobiology to β-cell biology: the changing perspective on type 1 diabetes. Islets. 6: e28778. PMID 25483958 DOI: 10.4161/Isl.28778  1
2014 Fonseca V, Del Prato S, Mirmira RG. Progress and change. Journal of Diabetes and Its Complications. PMID 25432316 DOI: 10.1016/j.jdiacomp.2014.11.004  0.01
2014 Templin AT, Maier B, Tersey SA, Hatanaka M, Mirmira RG. Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response. Molecular Endocrinology (Baltimore, Md.). 28: 1820-30. PMID 25251389 DOI: 10.1210/me.2014-1157  1
2014 Tersey SA, Maier B, Nishiki Y, Maganti AV, Nadler JL, Mirmira RG. 12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets. Molecular and Cellular Biology. 34: 3735-45. PMID 25071151 DOI: 10.1128/MCB.00157-14  1
2014 Elahi D, Mirmira RG, Kushner JA. Editorial: in praise of scientific review officers. Molecular Endocrinology (Baltimore, Md.). 28: 987-8. PMID 24983311 DOI: 10.1210/me.2014-1179  0.01
2014 Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, et al. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E2319-28. PMID 24843127 DOI: 10.1073/Pnas.1323066111  1
2014 Hatanaka M, Maier B, Sims EK, Templin AT, Kulkarni RN, Evans-Molina C, Mirmira RG. Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway. Diabetes. 63: 3404-15. PMID 24834975 DOI: 10.2337/Db14-0105  1
2014 Mirmira RG. Editorial: The vulnerable physician-scientist. Molecular Endocrinology (Baltimore, Md.). 28: 603-6. PMID 24786416 DOI: 10.1210/me.2014-1085  0.01
2014 Oh E, Stull ND, Mirmira RG, Thurmond DC. Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus. The Journal of Clinical Endocrinology and Metabolism. 99: E866-70. PMID 24552216 DOI: 10.1210/jc.2013-2221  1
2014 Imam S, Mirmira RG, Jaume JC. Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes. American Journal of Physiology. Endocrinology and Metabolism. 306: E791-8. PMID 24496311 DOI: 10.1152/ajpendo.00537.2013  0.01
2014 Tersey SA, Colvin SC, Maier B, Mirmira RG. Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy. Amino Acids. 46: 633-42. PMID 23846959 DOI: 10.1007/s00726-013-1560-7  1
2013 Colvin SC, Maier B, Morris DL, Tersey SA, Mirmira RG. Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes. The Journal of Biological Chemistry. 288: 36226-35. PMID 24196968 DOI: 10.1074/jbc.M113.473942  1
2013 Sims EK, Hatanaka M, Morris DL, Tersey SA, Kono T, Chaudry ZZ, Day KH, Moss DR, Stull ND, Mirmira RG, Evans-Molina C. Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains. American Journal of Physiology. Endocrinology and Metabolism. 305: E1495-511. PMID 24169046 DOI: 10.1152/Ajpendo.00366.2013  1
2013 Nishiki Y, Farb TB, Friedrich J, Bokvist K, Mirmira RG, Maier B. Characterization of a novel polyclonal anti-hypusine antibody. Springerplus. 2: 421. PMID 24024105 DOI: 10.1186/2193-1801-2-421  1
2013 Evans-Molina C, Hatanaka M, Mirmira RG. Lost in translation: endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitus. Diabetes, Obesity & Metabolism. 15: 159-69. PMID 24003933 DOI: 10.1111/Dom.12163  1
2013 Jaroch DB, Lu J, Madangopal R, Stull ND, Stensberg M, Shi J, Kahn JL, Herrera-Perez R, Zeitchek M, Sturgis J, Robinson JP, Yoder MC, Porterfield DM, Mirmira RG, Rickus JL. Mouse and human islets survive and function after coating by biosilicification. American Journal of Physiology. Endocrinology and Metabolism. 305: E1230-40. PMID 24002572 DOI: 10.1152/Ajpendo.00081.2013  0.01
2013 Fisher MM, Perez Chumbiauca CN, Mather KJ, Mirmira RG, Tersey SA. Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA. Endocrinology. 154: 3476-81. PMID 23825129 DOI: 10.1210/en.2013-1223  1
2013 Evans-Molina C, Mirmira RG. Achieving "PeaK-A" insulin secretion. Diabetes. 62: 1389-90. PMID 23613561 DOI: 10.2337/Db13-0196  1
2013 Cabrera SM, Colvin SC, Tersey SA, Maier B, Nadler JL, Mirmira RG. Effects of combination therapy with dipeptidyl peptidase-IV and histone deacetylase inhibitors in the non-obese diabetic mouse model of type 1 diabetes. Clinical and Experimental Immunology. 172: 375-82. PMID 23600825 DOI: 10.1111/cei.12068  1
2013 Green-Mitchell SM, Tersey SA, Cole BK, Ma K, Kuhn NS, Cunningham TD, Maybee NA, Chakrabarti SK, McDuffie M, Taylor-Fishwick DA, Mirmira RG, Nadler JL, Morris MA. Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. Plos One. 8: e56763. PMID 23437231 DOI: 10.1371/journal.pone.0056763  1
2013 Nishiki Y, Adewola A, Hatanaka M, Templin AT, Maier B, Mirmira RG. Translational control of inducible nitric oxide synthase by p38 MAPK in islet β-cells. Molecular Endocrinology (Baltimore, Md.). 27: 336-49. PMID 23250488 DOI: 10.1210/me.2012-1230  1
2013 Chen YC, Colvin ES, Maier BF, Mirmira RG, Fueger PT. Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death. Molecular Endocrinology (Baltimore, Md.). 27: 162-71. PMID 23204325 DOI: 10.1210/me.2012-1174  1
2012 Tersey SA, Carter JD, Rosenberg L, Taylor-Fishwick DA, Mirmira RG, Nadler JL. Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline. Journal of Diabetes Mellitus. 2: 251-257. PMID 26473085 DOI: 10.4236/jdm.2012.22040  0.01
2012 Stull ND, Breite A, McCarthy R, Tersey SA, Mirmira RG. Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease. Journal of Visualized Experiments : Jove. PMID 22987198 DOI: 10.3791/4137  0.04
2012 Eggleston E, Liu Z, Mirmira RG, Silva CM, Shu J, Santen RJ. Insights into mentorship for endocrinologists. The Journal of Clinical Endocrinology and Metabolism. 97: 3891-6. PMID 22969142 DOI: 10.1210/jc.2012-2215  0.01
2012 Cabrera SM, Rigby MR, Mirmira RG. Targeting regulatory T cells in the treatment of type 1 diabetes mellitus. Current Molecular Medicine. 12: 1261-72. PMID 22709273 DOI: 10.2174/156652412803833634  0.01
2012 Mirmira RG. Saturated free fatty acids: islet β cell "stressERs". Endocrine. 42: 1-2. PMID 22653726 DOI: 10.1007/s12020-012-9713-0  0.01
2012 Tersey SA, Nishiki Y, Templin AT, Cabrera SM, Stull ND, Colvin SC, Evans-Molina C, Rickus JL, Maier B, Mirmira RG. Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes. 61: 818-27. PMID 22442300 DOI: 10.2337/Db11-1293  1
2011 Templin AT, Maier B, Nishiki Y, Tersey SA, Mirmira RG. Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling. Cell Cycle (Georgetown, Tex.). 10: 1043-9. PMID 21389784 DOI: 10.4161/cc.10.7.15206  1
2011 Hinault C, Kawamori D, Liew CW, Maier B, Hu J, Keller SR, Mirmira RG, Scrable H, Kulkarni RN. Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice. Diabetes. 60: 1210-22. PMID 21357466 DOI: 10.2337/Db09-1379  1
2011 Fullenkamp AM, Bell LN, Robbins RD, Lee L, Saxena R, Alloosh M, Klaunig JE, Mirmira RG, Sturek M, Chalasani N. Effect of different obesogenic diets on pancreatic histology in Ossabaw miniature swine. Pancreas. 40: 438-43. PMID 21240032 DOI: 10.1097/Mpa.0B013E3182061583  1
2011 Shi J, McLamore ES, Jaroch D, Claussen JC, Mirmira RG, Rickus JL, Porterfield DM. Oscillatory glucose flux in INS 1 pancreatic β cells: a self-referencing microbiosensor study. Analytical Biochemistry. 411: 185-93. PMID 21167120 DOI: 10.1016/J.Ab.2010.12.019  0.01
2010 Ogihara T, Mirmira RG. An islet in distress: β cell failure in type 2 diabetes. Journal of Diabetes Investigation. 1: 123-33. PMID 24843420 DOI: 10.1111/j.2040-1124.2010.00021.x  1
2010 Robbins RD, Tersey SA, Ogihara T, Gupta D, Farb TB, Ficorilli J, Bokvist K, Maier B, Mirmira RG. Inhibition of deoxyhypusine synthase enhances islet β cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes Journal of Biological Chemistry. 285: 39943-39952. PMID 20956533 DOI: 10.1074/Jbc.M110.170142  1
2010 Maier B, Tersey SA, Mirmira RG. Hypusine: a new target for therapeutic intervention in diabetic inflammation. Discovery Medicine. 10: 18-23. PMID 20670594  1
2010 Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L, Sosa-Pineda B, Ogihara T, Mirmira RG, Sussel L, Stein R. Islet β-cell-specific MafA transcription requires the 5′-Flanking conserved region 3 control domain Molecular and Cellular Biology. 30: 4234-4244. PMID 20584984 DOI: 10.1128/Mcb.01396-09  1
2010 Sturek JM, Castle JD, Trace AP, Page LC, Castle AM, Evans-Molina C, Parks JS, Mirmira RG, Hedrick CC. An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. The Journal of Clinical Investigation. 120: 2575-89. PMID 20530872 DOI: 10.1172/Jci41280  1
2010 Zmuda EJ, Qi L, Zhu MX, Mirmira RG, Montminy MR, Hai T. The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Molecular Endocrinology (Baltimore, Md.). 24: 1423-33. PMID 20519332 DOI: 10.1210/Me.2009-0463  0.01
2010 Maier B, Ogihara T, Trace AP, Tersey SA, Robbins RD, Chakrabarti SK, Nunemaker CS, Stull ND, Taylor CA, Thompson JE, Dondero RS, Lewis EC, Dinarello CA, Nadler JL, Mirmira RG. The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. The Journal of Clinical Investigation. 120: 2156-70. PMID 20501948 DOI: 10.1172/Jci38924  1
2010 Crim WS, Wu R, Carter JD, Cole BK, Trace AP, Mirmira RG, Kunsch C, Nadler JL, Nunemaker CS. AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Molecular and Cellular Endocrinology. 323: 246-55. PMID 20211684 DOI: 10.1016/J.Mce.2010.02.041  1
2010 Mirmira RG. Stem cells and the future of organ transplantation. Current Opinion in Organ Transplantation. 15: 52-3. PMID 20071989 DOI: 10.1097/MOT.0b013e328334c8e8  0.01
2010 Ogihara T, Chuang JC, Vestermark GL, Garmey JC, Ketchum RJ, Huang X, Brayman KL, Thorner MO, Repa JJ, Mirmira RG, Evans-Molina C. Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. The Journal of Biological Chemistry. 285: 5392-404. PMID 20007976 DOI: 10.1074/Jbc.M109.064659  1
2010 Robbins RD, Prasain N, Maier BF, Yoder MC, Mirmira RG. Inducible pluripotent stem cells: not quite ready for prime time? Current Opinion in Organ Transplantation. 15: 61-7. PMID 19855280 DOI: 10.1097/Mot.0B013E3283337196  1
2010 Ogihara T, Mirmira RG. An islet in distress: β cell failure in type 2 diabetes Journal of Diabetes Investigation. 1: 123-133. DOI: 10.1111/j.2040-1124.2010.00021.x  1
2009 Ogihara T, Vanderford NL, Maier B, Stein RW, Mirmira RG. Expression and function of Set7/9 in pancreatic islets. Islets. 1: 269-72. PMID 21099283 DOI: 10.4161/Isl.1.3.9779  1
2009 Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, Stoffers DA. Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proceedings of the National Academy of Sciences of the United States of America. 106: 19090-5. PMID 19855005 DOI: 10.1073/Pnas.0904849106  1
2009 Evans-Molina C, Vestermark GL, Mirmira RG. Development of insulin-producing cells from primitive biologic precursors. Current Opinion in Organ Transplantation. 14: 56-63. PMID 19337148 DOI: 10.1097/Mot.0B013E3283186Fc1  1
2009 Chhabra P, Mirmira RG, Brayman KL. Regenerative medicine and tissue engineering: contribution of stem cells in organ transplantation. Current Opinion in Organ Transplantation. 14: 46-50. PMID 19337146 DOI: 10.1097/MOT.0b013e328322f989  0.01
2009 Evans-Molina C, Robbins RD, Kono T, Tersey SA, Vestermark GL, Nunemaker CS, Garmey JC, Deering TG, Keller SR, Maier B, Mirmira RG. Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure. Molecular and Cellular Biology. 29: 2053-67. PMID 19237535 DOI: 10.1128/Mcb.01179-08  1
2009 Antkowiak PF, Tersey SA, Carter JD, Vandsburger MH, Nadler JL, Epstein FH, Mirmira RG. Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging. American Journal of Physiology. Endocrinology and Metabolism. 296: E573-8. PMID 19116376 DOI: 10.1152/Ajpendo.90336.2008  1
2009 Deering TG, Ogihara T, Trace AP, Maier B, Mirmira RG. Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes. Diabetes. 58: 185-93. PMID 18984737 DOI: 10.2337/db08-1150  1
2008 Hinault C, Hu J, Maier BF, Mirmira RG, Kulkarni RN. Differential expression of cell cycle proteins during ageing of pancreatic islet cells. Diabetes, Obesity & Metabolism. 10: 136-46. PMID 18834441 DOI: 10.1111/j.1463-1326.2008.00947.x  0.04
2008 Chuang JC, Cha JY, Garmey JC, Mirmira RG, Repa JJ. Research resource: nuclear hormone receptor expression in the endocrine pancreas. Molecular Endocrinology (Baltimore, Md.). 22: 2353-63. PMID 18669644 DOI: 10.1210/me.2007-0568  1
2008 Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Tessem JS, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, Newgard CB. Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Molecular and Cellular Biology. 28: 3465-76. PMID 18347054 DOI: 10.1128/Mcb.01791-07  1
2008 Fueger PT, Schisler JC, Lu D, Babu DA, Mirmira RG, Newgard CB, Hohmeier HE. Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. Molecular Endocrinology (Baltimore, Md.). 22: 1251-9. PMID 18258687 DOI: 10.1210/Me.2007-0500  1
2008 Babu DA, Chakrabarti SK, Garmey JC, Mirmira RG. Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene. The Journal of Biological Chemistry. 283: 8164-72. PMID 18252719 DOI: 10.1074/Jbc.M800336200  1
2008 Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V. Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes. 57: 424-31. PMID 17991758 DOI: 10.2337/Db07-1285  1
2007 Babu DA, Deering TG, Mirmira RG. A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis. Molecular Genetics and Metabolism. 92: 43-55. PMID 17659992 DOI: 10.1016/J.Ymgme.2007.06.008  1
2007 Evans-Molina C, Garmey JC, Ketchum R, Brayman KL, Deng S, Mirmira RG. Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets. Diabetes. 56: 827-35. PMID 17327454 DOI: 10.2337/Db06-1440  1
2006 Francis J, Babu DA, Deering TG, Chakrabarti SK, Garmey JC, Evans-Molina C, Taylor DG, Mirmira RG. Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1. Molecular Endocrinology (Baltimore, Md.). 20: 3133-45. PMID 16901969 DOI: 10.1210/Me.2006-0126  1
2005 Francis J, Chakrabarti SK, Garmey JC, Mirmira RG. Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription. The Journal of Biological Chemistry. 280: 36244-53. PMID 16141209 DOI: 10.1074/Jbc.M505741200  1
2005 Taylor DG, Babu D, Mirmira RG. The C-terminal domain of the beta cell homeodomain factor Nkx6.1 enhances sequence-selective DNA binding at the insulin promoter. Biochemistry. 44: 11269-78. PMID 16101311 DOI: 10.1021/Bi050821M  1
2005 Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB. The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells Proceedings of the National Academy of Sciences of the United States of America. 102: 7297-7302. PMID 15883383 DOI: 10.1073/Pnas.0502168102  1
2005 Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG. Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: Application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes Journal of Biological Chemistry. 280: 16798-16807. PMID 15743769 DOI: 10.1074/Jbc.M414381200  1
2004 Gasa R, Mrejen C, Leachman N, Otten M, Barnes M, Wang J, Chakrabarti S, Mirmira R, German M. Proendocrine genes coordinate the pancreatic islet differentiation program in vitro. Proceedings of the National Academy of Sciences of the United States of America. 101: 13245-50. PMID 15340143 DOI: 10.1073/Pnas.0405301101  0.01
2004 Iype T, Taylor DG, Ziesmann SM, Garmey JC, Watada H, Mirmira RG. The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1. Molecular Endocrinology (Baltimore, Md.). 18: 1363-75. PMID 15056733 DOI: 10.1210/me.2004-0006  1
2003 Chakrabarti SK, Francis J, Ziesmann SM, Garmey JC, Mirmira RG. Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells. The Journal of Biological Chemistry. 278: 23617-23. PMID 12711597 DOI: 10.1074/Jbc.M303423200  1
2003 Chakrabarti SK, Mirmira RG. Transcription factors direct the development and function of pancreatic beta cells. Trends in Endocrinology and Metabolism: Tem. 14: 78-84. PMID 12591178  1
2002 Chakrabarti SK, James JC, Mirmira RG. Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. The Journal of Biological Chemistry. 277: 13286-93. PMID 11825903 DOI: 10.1074/jbc.M111857200  1
2001 Lee JC, Smith SB, Watada H, Lin J, Scheel D, Wang J, Mirmira RG, German MS. Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes. 50: 928-36. PMID 11334435 DOI: 10.2337/Diabetes.50.5.928  0.01
2000 Watada H, Mirmira RG, Kalamaras J, German MS. Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins. Proceedings of the National Academy of Sciences of the United States of America. 97: 9443-8. PMID 10944215 DOI: 10.1073/PNAS.97.17.9443  0.01
2000 Watada H, Mirmira RG, Leung J, German MS. Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1. The Journal of Biological Chemistry. 275: 34224-30. PMID 10938085 DOI: 10.1074/jbc.M004981200  0.01
2000 Mirmira RG, Watada H, German MS. Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains. The Journal of Biological Chemistry. 275: 14743-51. PMID 10799563 DOI: 10.1074/JBC.275.19.14743  0.01
2000 Ohneda K, Mirmira RG, Wang J, Johnson JD, German MS. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Molecular and Cellular Biology. 20: 900-11. PMID 10629047 DOI: 10.1128/MCB.20.3.900-911.2000  0.01
1997 Ku J, Mirmira RG, Liu L, Santi DV. Expression of a functional non-ribosomal peptide synthetase module in Escherichia coli by coexpression with a phosphopantetheinyl transferase. Chemistry & Biology. 4: 203-7. PMID 9115412 DOI: 10.1016/S1074-5521(97)90289-1  0.01
1991 Kotake S, Hey P, Mirmira RG, Copeland RA. Physicochemical characterization of bovine retinal arrestin. Archives of Biochemistry and Biophysics. 285: 126-33. PMID 1990970 DOI: 10.1016/0003-9861(91)90338-J  0.01
1991 Mirmira RG, Tager HS. Disposition of the phenylalanine B25 side chain during insulin-receptor and insulin-insulin interactions. Biochemistry. 30: 8222-9. PMID 1868095 DOI: 10.1021/Bi00247A019  1
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