Francis C. Lynn, Ph.D. - Publications

2003 University of British Columbia, Vancouver, Vancouver, BC, Canada 
Animal Physiology Biology, Molecular Biology, Pathology

15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang CH, Sagar, Arrigoni L, Dalgaard K, Teperino R, Enders L, Selvaraj M, Ruf M, Raja SJ, ... ... Lynn FC, et al. The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes. Cell Metabolism. PMID 29754954 DOI: 10.1016/j.cmet.2018.04.013  0.32
2018 Sabatini PV, Speckmann T, Nian C, Glavas MM, Wong CK, Yoon JS, Kin T, Shapiro AMJ, Gibson WT, Verchere CB, Lynn FC. Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine Cells. Cell Reports. 22: 163-174. PMID 29298418 DOI: 10.1016/j.celrep.2017.12.033  0.4
2017 Xu EE, Sasaki S, Speckmann T, Nian C, Lynn FC. SOX4 Allows Facultative β-Cell Proliferation Through Repression of Cdkn1a. Diabetes. PMID 28495880 DOI: 10.2337/db16-1074  0.4
2017 Krentz NAJ, van Hoof D, Li Z, Watanabe A, Tang M, Nian C, German MS, Lynn FC. Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors. Developmental Cell. 41: 129-142.e6. PMID 28441528 DOI: 10.1016/j.devcel.2017.02.006  0.4
2015 Speckmann T, Sabatini PV, Nian C, Smith RG, Lynn FC. Npas4 transcription factor expression is regulated by calcium signalling pathways and prevents tacrolimus-induced cytotoxicity in pancreatic beta cells. The Journal of Biological Chemistry. PMID 26663079 DOI: 10.1074/jbc.M115.704098  0.4
2015 Xu EE, Krentz NA, Tan S, Chow SZ, Tang M, Nian C, Lynn FC. SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia. 58: 1013-23. PMID 25652387 DOI: 10.1007/s00125-015-3507-x  0.4
2014 Krentz NA, Nian C, Lynn FC. TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm. Plos One. 9: e114275. PMID 25474420 DOI: 10.1371/journal.pone.0114275  0.4
2014 Chow SZ, Speck M, Yoganathan P, Nackiewicz D, Hansen AM, Ladefoged M, Rabe B, Rose-John S, Voshol PJ, Lynn FC, Herrera PL, Müller W, Ellingsgaard H, Ehses JA. Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes. Diabetes. 63: 2984-95. PMID 24812426 DOI: 10.2337/db13-1121  0.32
2013 Sabatini PV, Krentz NA, Zarrouki B, Westwell-Roper CY, Nian C, Uy RA, Shapiro AM, Poitout V, Lynn FC. Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells. Diabetes. 62: 2808-20. PMID 23656887 DOI: 10.2337/db12-1527  0.4
2003 Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes. 52: 741-50. PMID 12606516  0.4
2003 Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA. Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis. American Journal of Physiology. Endocrinology and Metabolism. 284: E931-9. PMID 12540373 DOI: 10.1152/ajpendo.00270.2002  0.4
2003 Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA. A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 91-3. PMID 12475913 DOI: 10.1096/fj.02-0243fje  0.4
2001 Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. 50: 1004-11. PMID 11334402  0.4
1999 McIntosh CH, Bremsak I, Lynn FC, Gill R, Hinke SA, Gelling R, Nian C, McKnight G, Jaspers S, Pederson RA. Glucose-Dependent Insulinotropic Polypeptide Stimulation of Lipolysis in Differentiated 3T3-L1 Cells: Wortmannin-Sensitive Inhibition by Insulin* * This work was supported by grants from Zymogenetics Inc. (Seattle, WA), the Medical Research Council of Canada (5-90007-RAP/CHSM) and the Canadian Diabetes Association (CHSM/RAP). Endocrinology. 140: 398-404. PMID 28200744 DOI: 10.1210/endo.140.1.6464  0.4
1999 McIntosh CH, Bremsak I, Lynn FC, Gill R, Hinke SA, Gelling R, Nian C, McKnight G, Jaspers S, Pederson RA. Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin. Endocrinology. 140: 398-404. PMID 9886851 DOI: 10.1210/endo.140.1.6464  0.4
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