| Year |
Citation |
Score |
| 2022 |
Vekariya U, Toma MM, Nieborowska-Skorska M, Le BV, Caron MC, Kukuyan AM, Sullivan-Reed K, Podszywalow-Bartnicka P, Chitrala KN, Atkins J, Drzewiecka M, Feng W, Chan J, Chatla S, Golovine K, ... ... Sykes S, et al. DNA polymerase theta protects leukemia cells from metabolic-induced DNA damage. Blood. PMID 36580665 DOI: 10.1182/blood.2022018428 |
0.332 |
|
| 2021 |
Maifrede S, Le BV, Nieborowska-Skorska M, Golovine K, Sullivan-Reed K, Dunuwille WMB, Nacson J, Hulse M, Keith K, Madzo J, Caruso LB, Gazze Z, Lian Z, Padella A, Chitrala KN, ... ... Sykes SM, et al. TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors. Cancer Research. PMID 34215619 DOI: 10.1158/0008-5472.CAN-20-3761 |
0.357 |
|
| 2021 |
Stanek TJ, Gennaro VJ, Tracewell MA, Di Marcantonio D, Pauley KL, Butt S, McNair C, Wang F, Kossenkov AV, Knudsen KE, Butt T, Sykes SM, McMahon SB. The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22. The Embo Journal. e102509. PMID 34155658 DOI: 10.15252/embj.2019102509 |
0.59 |
|
| 2020 |
Nacson J, Di Marcantonio D, Wang Y, Bernhardy AJ, Clausen E, Hua X, Cai KQ, Martinez E, Feng W, Callén E, Wu W, Gupta GP, Testa JR, Nussenzweig A, Sykes SM, et al. BRCA1 Mutational Complementation Induces Synthetic Viability. Molecular Cell. PMID 32359443 DOI: 10.1016/J.Molcel.2020.04.006 |
0.366 |
|
| 2019 |
Peshkova IO, Aghayev T, Fatkhullina AR, Makhov P, Titerina EK, Eguchi S, Tan YF, Kossenkov AV, Khoreva MV, Gankovskaya LV, Sykes SM, Koltsova EK. IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development. Nature Communications. 10: 5046. PMID 31695038 DOI: 10.1038/S41467-019-13017-4 |
0.307 |
|
| 2019 |
Di Marcantonio D, Sykes SM. Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia. Journal of Visualized Experiments : Jove. PMID 31545325 DOI: 10.3791/59593 |
0.311 |
|
| 2019 |
Sykes SM. NCAM1 supports therapy resistance and LSC function in AML. Blood. 133: 2247-2248. PMID 31122937 DOI: 10.1182/Blood-2019-03-901017 |
0.377 |
|
| 2018 |
Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, ... ... Sykes SM, et al. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Reports. 25: 1384. PMID 30380426 DOI: 10.1016/J.Celrep.2018.10.009 |
0.338 |
|
| 2018 |
Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, ... ... Sykes SM, et al. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Reports. 24: 3513-3527.e7. PMID 30257212 DOI: 10.1016/J.Celrep.2018.08.086 |
0.42 |
|
| 2018 |
Maifrede S, Nieborowska-Skorska M, Sullivan K, Dasgupta Y, Podszywalow-Bartnicka P, Le BV, Solecka M, Lian Z, Belyaeva EA, Nersesyan A, Machnicki MM, Toma M, Chatain N, Rydzanicz M, Zhao H, ... ... Sykes SM, et al. Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors. Blood. PMID 29784639 DOI: 10.1182/Blood-2018-02-834895 |
0.433 |
|
| 2018 |
Rudat S, Pfaus A, Cheng YY, Holtmann J, Ellegast JM, Bühler C, Marcantonio DD, Martinez E, Göllner S, Wickenhauser C, Müller-Tidow C, Lutz C, Bullinger L, Milsom MD, Sykes SM, et al. RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia. Leukemia. PMID 29654265 DOI: 10.1038/S41375-018-0102-4 |
0.425 |
|
| 2018 |
Di Marcantonio D, Masselli E, Martinez E, Araiza-Olivera D, Gobbi G, Mirandola P, Vitale M, Sykes SM. Pkcε Is a Central Regulator of Mitochondrial Function and Metabolism in Acute Myeloid Leukemia Blood. 132: 3926-3926. DOI: 10.1182/Blood-2018-99-119758 |
0.401 |
|
| 2018 |
Sykes SM, Di Marcantonio D, Martinez E, Huhn J, Gupta A, Mistry R. JUN and ATF3 Regulate the Transcriptional Output of the Unfolded Protein Response to Support Acute Myeloid Leukemia Blood. 132: 1327-1327. DOI: 10.1182/Blood-2018-99-119742 |
0.494 |
|
| 2017 |
Di Marcantonio D, Martinez E, Sidoli S, Vadaketh J, Nieborowska-Skorska M, Gupta A, Meadows JM, Ferraro F, Masselli E, Challen GA, Milsom MD, Scholl C, Froehling S, Balachandran S, Skorski T, ... ... Sykes SM, et al. PKC epsilon is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29127121 DOI: 10.1158/1078-0432.Ccr-17-2684 |
0.337 |
|
| 2017 |
Nieborowska-Skorska M, Sullivan K, Dasgupta Y, Podszywalow-Bartnicka P, Hoser G, Maifrede S, Martinez E, Di Marcantonio D, Bolton-Gillespie E, Cramer-Morales K, Lee J, Li M, Slupianek A, Gritsyuk D, Cerny-Reiterer S, ... ... Sykes SM, et al. Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. The Journal of Clinical Investigation. PMID 28481221 DOI: 10.1172/Jci90825 |
0.471 |
|
| 2016 |
Zhou C, Martinez E, Di Marcantonio D, Patel-Solanki N, Aghayev T, Peri S, Ferraro F, Skorski T, Scholl C, Fröhling S, Balachandran S, Wiest DL, Sykes SM. JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia. Leukemia. PMID 27840425 DOI: 10.1038/Leu.2016.329 |
0.439 |
|
| 2016 |
Monteith JA, Mellert H, Sammons MA, Kuswanto LA, Sykes SM, Resnick-Silverman L, Manfredi JJ, Berger SL, McMahon SB. A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction. Molecular Oncology. PMID 27341992 DOI: 10.1016/J.Molonc.2016.05.007 |
0.759 |
|
| 2016 |
Rudat S, Pfaus A, Bühler C, Rabe S, Bullinger L, Gröschel S, Sykes SM, Milsom MD, Ellegast JM, Fröhling S, Scholl C. The RET Receptor Tyrosine Kinase Promotes Acute Myeloid Leukemia through Protection of FLT3-ITD Mutants from Autophagic Degradation Blood. 128: 2849-2849. DOI: 10.1182/Blood.V128.22.2849.2849 |
0.445 |
|
| 2016 |
Harris B, Fahl S, Perrigoue J, Sykes SM, Verma A, Wiest DL. Ribosomal Protein L22 Loss Predisposes Stem Cells to Transformation By Altering Metabolism Blood. 128: 2733-2733. DOI: 10.1182/Blood.V128.22.2733.2733 |
0.379 |
|
| 2015 |
Sykes SM, Kokkaliaris KD, Milsom MD, Levine RL, Majeti R. Clonal Evolution of Preleukemic hematopoietic stem cells in acute myeloid leukemia. Experimental Hematology. PMID 26455528 DOI: 10.1016/J.Exphem.2015.08.012 |
0.363 |
|
| 2015 |
Harris B, Perrigoue J, Kessel RM, Fahl S, Sykes SM, Verma A, Wiest DL. Rpl22 Deficiency Predisposes Hematopoietic Stem and Progenitor Cells to Leukemogenesis Blood. 126: 899-899. DOI: 10.1182/Blood.V126.23.899.899 |
0.406 |
|
| 2015 |
Di Marcantonio D, Vadaketh J, Martinez E, Mirandola P, Gobbi G, Milsom MD, Scholl C, Fröhling S, Vitale M, Sykes SM. Pkc Epsilon Regulates Mitochondrial Redox Biology to Support the Differentiation Blockade in Acute Myeloid Leukemia Blood. 126: 444-444. DOI: 10.1182/Blood.V126.23.444.444 |
0.485 |
|
| 2015 |
Zhou C, Di Marcantonio D, Martinez E, Solanki-Patel N, Peri S, Scholl C, Fröhling S, Wiest DL, Sykes SM. C-Jun Regulates ER Stress Signaling to Promote Chemotherapy Resistance in Acute Myeloid Leukemia Blood. 126: 2464-2464. DOI: 10.1182/Blood.V126.23.2464.2464 |
0.405 |
|
| 2015 |
Aghayev T, Zhou C, Klein A, Martinez E, Scholl C, Fröhling S, Sykes SM. Foxos Suppress Lipid Peroxidation to Promote AML Progression and Chemotherapy Resistance Blood. 126: 1861-1861. DOI: 10.1182/Blood.V126.23.1861.1861 |
0.486 |
|
| 2014 |
Lee D, Sykes SM, Kalaitzidis D, Lane AA, Kfoury Y, Raaijmakers MH, Wang YH, Armstrong SA, Scadden DT. Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. Stem Cell Reports. 3: 832-40. PMID 25418727 DOI: 10.1016/j.stemcr.2014.08.011 |
0.301 |
|
| 2014 |
Limon JJ, So L, Jellbauer S, Chiu H, Corado J, Sykes SM, Raffatellu M, Fruman DA. mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition. Proceedings of the National Academy of Sciences of the United States of America. 111: E5076-85. PMID 25385646 DOI: 10.1073/Pnas.1407104111 |
0.352 |
|
| 2014 |
Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, et al. Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning. Blood. 124: 2937-47. PMID 25202142 DOI: 10.1182/Blood-2014-08-593426 |
0.364 |
|
| 2014 |
Placke T, Faber K, Nonami A, Putwain SL, Salih HR, Heidel FH, Krämer A, Root DE, Barbie DA, Krivtsov AV, Armstrong SA, Hahn WC, Huntly BJ, Sykes SM, Milsom MD, et al. Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. Blood. 124: 13-23. PMID 24764564 DOI: 10.1182/Blood-2014-02-558114 |
0.454 |
|
| 2014 |
Nieborowska-Skorska M, Sullivan K, Podszywalow-Bartnicka P, Hoser G, Bolton-Gillespie E, Cramer-Morales K, Slupianek A, Zhou C, Cerny-Reiterer S, Stoklosa T, Sykes SM, Valent P, Civin CI, Muschen M, Minden MD, et al. Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells Blood. 124: 480-480. DOI: 10.1182/Blood.V124.21.480.480 |
0.467 |
|
| 2013 |
Sykes SM, Scadden DT. Modeling human hematopoietic stem cell biology in the mouse. Seminars in Hematology. 50: 92-100. PMID 24216169 DOI: 10.1053/J.Seminhematol.2013.03.029 |
0.36 |
|
| 2013 |
Gobbi G, Mirandola P, Carubbi C, Masselli E, Sykes SM, Ferraro F, Nouvenne A, Thon JN, Italiano JE, Vitale M. Proplatelet generation in the mouse requires PKCε-dependent RhoA inhibition. Blood. 122: 1305-11. PMID 23838351 DOI: 10.1182/Blood-2013-04-490599 |
0.32 |
|
| 2013 |
Faber K, Bullinger L, Ragu C, Garding A, Mertens D, Miller C, Martin D, Walcher D, Döhner K, Döhner H, Claus R, Plass C, Sykes SM, Lane SW, Scholl C, et al. CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling. The Journal of Clinical Investigation. 123: 299-314. PMID 23202735 DOI: 10.1172/Jci64745 |
0.454 |
|
| 2013 |
Nieborowska-Skorska M, Slupianek A, Hoser G, Bolton-Gillespie E, Tulin A, Cerny-Reiterer S, Valent P, Muschen M, Sykes SM, Skorski T. Oncogene-Induced DNA Repair Defects Promote PARP1-Mediated “Dual Synthetic Lethality” To Eradicate Quiescent and Proliferating Leukemia Stem and Progenitor Cells Blood. 122: 810-810. DOI: 10.1182/Blood.V122.21.810.810 |
0.468 |
|
| 2012 |
Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA, Armstrong SA. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 11: 429-39. PMID 22958934 DOI: 10.1016/j.stem.2012.06.009 |
0.398 |
|
| 2012 |
Saez B, Ferraro F, Yusuf RZ, Cook CM, Sykes SM, Pardo A, Yu VW, Lotinun S, Palchaudhuri R, Lee D, Lymperi S, Day R, Vasic R, Acharya SS, Baron R, et al. Hematopoietic Stem/Progenitor Cell Retention in the Bone Marrow Depends On Tissue Specific Heparan Sulfate Proteoglycans Blood. 120: 637-637. DOI: 10.1182/Blood.V120.21.637.637 |
0.382 |
|
| 2012 |
Yusuf RZ, Acharya SS, Yu VW, Saez B, Cobert JM, Doench J, Bullinger L, S'aulis D, Lee D, Palchaudhuri R, Uzosike AC, Duvet M, Logan DJ, Das S, Cook CM, ... ... Sykes SM, et al. Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells Blood. 120: 208-208. DOI: 10.1182/Blood.V120.21.208.208 |
0.414 |
|
| 2011 |
Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Schöll C, Tothova Z, Attar EC, et al. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 146: 697-708. PMID 21884932 DOI: 10.1016/J.Cell.2011.07.032 |
0.433 |
|
| 2011 |
Lane SW, Wang YJ, Lo Celso C, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DA. Differential niche and Wnt requirements during acute myeloid leukemia progression Blood. 118: 2849-2856. PMID 21765021 DOI: 10.1182/Blood-2011-03-345165 |
0.383 |
|
| 2011 |
Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T. Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. Blood. 118: 1264-73. PMID 21653327 DOI: 10.1182/Blood-2011-01-328567 |
0.377 |
|
| 2011 |
Mellert HS, Stanek TJ, Sykes SM, Rauscher FJ, Schultz DC, McMahon SB. Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis. The Journal of Biological Chemistry. 286: 4264-70. PMID 21148320 DOI: 10.1074/Jbc.M110.184663 |
0.773 |
|
| 2011 |
Yusuf RZ, Acharya SS, Yu V, Saez B, Duvet M, Scadden E, Warraich G, Clish C, Churchill M, Doench J, Logan DJ, Cook C, Das S, Brown A, Sykes SM, et al. Distinct Metabolic Dependency of Normal and Leukemic Cells in a Mouse Model Blood. 118: 759-759. DOI: 10.1182/Blood.V118.21.759.759 |
0.356 |
|
| 2011 |
Faber K, Bullinger L, Garding A, Mertens D, Martin D, Walcher D, Döhner K, Döhner H, Sykes SM, Claus R, Plass C, Lane SW, Scholl C, Fröhling S. Myeloid Leukemogenesis Driven by Aberrant CDX2 Expression Involves Transcriptional Repression of KLF4 and Deregulated PPARγ Signaling Blood. 118: 1355-1355. DOI: 10.1182/Blood.V118.21.1355.1355 |
0.472 |
|
| 2011 |
Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Fröhling S, et al. Erratum: AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias (Cell (2011) 146 (697-708)) Cell. 147. DOI: 10.1016/J.Cell.2011.09.015 |
0.359 |
|
| 2010 |
Parmar K, Kim J, Sykes SM, Shimamura A, Stuckert P, Zhu K, Hamilton A, Deloach MK, Kutok JL, Akashi K, Gilliland DG, D'andrea A. Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1. Stem Cells (Dayton, Ohio). 28: 1186-95. PMID 20506303 DOI: 10.1002/Stem.437 |
0.315 |
|
| 2010 |
Lane SW, Sykes SM, Al-Shahrour F, Shterental S, Paktinat M, Lo Celso C, Jesneck JL, Ebert BL, Williams DA, Gilliland DG. The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood. 115: 3489-97. PMID 20197553 DOI: 10.1182/Blood-2009-11-251728 |
0.382 |
|
| 2010 |
Lane SW, Sykes SM, Ferraro F, Lin CP, Gilliland DG, Williams DA, Scadden DT, Celso CL. Leukemia stem cells occupy niches that are physically distinct and independent of the normal constraints that apply to hematopoietic stem cells Experimental Hematology. 38. DOI: 10.1016/J.Exphem.2010.07.008 |
0.316 |
|
| 2009 |
Sykes SM, Stanek TJ, Frank A, Murphy ME, McMahon SB. Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. The Journal of Biological Chemistry. 284: 20197-205. PMID 19494119 DOI: 10.1074/Jbc.M109.026096 |
0.723 |
|
| 2009 |
Cornejo MG, Sykes SM, Celso CL, Tothova Z, Aster J, DePinho RA, Scadden DT, Gilliland DG, Mercher T. A Regulatory Network Between Notch and AKT Signaling Pathways Differentially Controls Megakaryocyte Development From Hematopoietic Stem or Committed Progenitor Cells. Blood. 114: 384-384. DOI: 10.1182/Blood.V114.22.384.384 |
0.417 |
|
| 2009 |
Lane SW, Celso CL, Sykes SM, Shterental S, Paktinat M, Lin CP, Williams DA, Scadden DT, Gilliland DG. Leukemia Stem Cells Are Resistant to In Vivo, Cell Non-Autonomous Wnt Inhibition. Blood. 114: 1025-1025. DOI: 10.1182/Blood.V114.22.1025.1025 |
0.421 |
|
| 2008 |
Pietsch EC, Sykes SM, McMahon SB, Murphy ME. The p53 family and programmed cell death. Oncogene. 27: 6507-21. PMID 18955976 DOI: 10.1038/Onc.2008.315 |
0.704 |
|
| 2008 |
Zhang XY, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL, McMahon SB. The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Molecular Cell. 29: 102-11. PMID 18206973 DOI: 10.1016/J.Molcel.2007.12.015 |
0.652 |
|
| 2008 |
Tothova Z, Sykes SM, Leeman DS, Horner JW, Sharpless N, DePinho RA, Gilliland DG. p16INK4a Is a Key Downstream Mediator of the Deleterious Effects of FoxO Deficiency on Maintenance of the Hematopoietic Stem Cell Compartment. Blood. 112: 1405-1405. DOI: 10.1182/Blood.V112.11.1405.1405 |
0.413 |
|
| 2007 |
Mellert H, Sykes SM, Murphy ME, McMahon SB. The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle (Georgetown, Tex.). 6: 1304-6. PMID 17534149 DOI: 10.4161/Cc.6.11.4343 |
0.756 |
|
| 2006 |
Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Molecular Cell. 24: 841-51. PMID 17189187 DOI: 10.1016/J.Molcel.2006.11.026 |
0.765 |
|
| 2004 |
Schnepp RW, Mao H, Sykes SM, Zong WX, Silva A, La P, Hua X. Menin induces apoptosis in murine embryonic fibroblasts. The Journal of Biological Chemistry. 279: 10685-91. PMID 14688275 DOI: 10.1074/Jbc.M308073200 |
0.399 |
|
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