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Daniel M. Appledorn, Ph.D. - Publications

Affiliations: 
2006 Michigan State University, East Lansing, MI 
Area:
Cell Biology
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Schramm CL, Rauch JN, Oupicka L, Skerlos LA, Bevan NJ, Lovell GF, Perez-Garrido S, Filonov GS, Chen YX, Kovalenko I, Foltin S, Campwala H, Dale TJ, Appledorn DM. Abstract 1834: Real-time visualization and quantification of flexible, multi-parameter indicators of cancer cell heath and metabolism using live-cell analysis Cancer Research. 80: 1834-1834. DOI: 10.1158/1538-7445.Am2020-1834  0.339
2016 Roddy M, Rauch J, O’Clair L, Appledorn DM. Abstract 5084: Real-time, quantitative cellular analysis of migration and invasion Cancer Research. 76: 5084-5084. DOI: 10.1158/1538-7445.Am2016-5084  0.318
2015 Quiroga D, Aldhamen YA, Appledorn DM, Godbehere S, Amalfitano A. Strengthened tumor antigen immune recognition by inclusion of a recombinant Eimeria antigen in therapeutic cancer vaccination. Cancer Immunology, Immunotherapy : Cii. 64: 479-91. PMID 25655760 DOI: 10.1007/S00262-015-1659-7  0.429
2013 Aldhamen YA, Seregin SS, Kousa YA, Rastall DP, Appledorn DM, Godbehere S, Schutte BC, Amalfitano A. Improved cytotoxic T-lymphocyte immune responses to a tumor antigen by vaccines co-expressing the SLAM-associated adaptor EAT-2. Cancer Gene Therapy. 20: 564-75. PMID 23949283 DOI: 10.1038/Cgt.2013.53  0.451
2011 Schuldt NJ, Aldhamen YA, Appledorn DM, Seregin SS, Kousa Y, Godbehere S, Amalfitano A. Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses. Plos One. 6: e24147. PMID 21912619 DOI: 10.1371/Journal.Pone.0024147  0.41
2011 Seregin SS, Aldhamen YA, Appledorn DM, Aylsworth CF, Godbehere S, Liu CJ, Quiroga D, Amalfitano A. TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo. Plos One. 6: e22064. PMID 21760953 DOI: 10.1371/Journal.Pone.0022064  0.465
2011 Seregin SS, Aldhamen YA, Appledorn DM, Zehnder J, Voss T, Godbehere S, Amalfitano A. Use of DAF-displaying adenovirus vectors reduces induction of transgene- and vector-specific adaptive immune responses in mice. Human Gene Therapy. 22: 1083-94. PMID 21388344 DOI: 10.1089/Hum.2010.218  0.435
2011 Aldhamen YA, Appledorn DM, Seregin SS, Liu CJ, Schuldt NJ, Godbehere S, Amalfitano A. Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens. Journal of Immunology (Baltimore, Md. : 1950). 186: 722-32. PMID 21149608 DOI: 10.4049/Jimmunol.1002105  0.452
2011 Appledorn DM, Aldhamen YA, Godbehere S, Seregin SS, Amalfitano A. Sublingual administration of an adenovirus serotype 5 (Ad5)-based vaccine confirms Toll-like receptor agonist activity in the oral cavity and elicits improved mucosal and systemic cell-mediated responses against HIV antigens despite preexisting Ad5 immunity. Clinical and Vaccine Immunology : Cvi. 18: 150-60. PMID 21084461 DOI: 10.1128/Cvi.00341-10  0.424
2011 Patial S, Shahi S, Saini Y, Lee T, Packiriswamy N, Appledorn DM, Lapres JJ, Amalfitano A, Parameswaran N. G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice. Journal of Cellular Physiology. 226: 1323-33. PMID 20945396 DOI: 10.1002/Jcp.22460  0.332
2011 Patial S, Saini Y, Parvataneni S, Appledorn DM, Dorn GW, Lapres JJ, Amalfitano A, Senagore P, Parameswaran N. Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice. Journal of Cellular Physiology. 226: 627-37. PMID 20717897 DOI: 10.1002/Jcp.22384  0.355
2010 Seregin SS, Aldhamen YA, Appledorn DM, Hartman ZC, Schuldt NJ, Scott J, Godbehere S, Jiang H, Frank MM, Amalfitano A. Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo. Blood. 116: 1669-77. PMID 20511542 DOI: 10.1182/Blood-2010-03-276949  0.427
2010 Seregin SS, Hartman ZC, Appledorn DM, Godbehere S, Jiang H, Frank MM, Amalfitano A. Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor. Journal of Innate Immunity. 2: 353-9. PMID 20375551 DOI: 10.1159/000284368  0.347
2010 Appledorn DM, Aldhamen YA, Depas W, Seregin SS, Liu CJ, Schuldt N, Quach D, Quiroga D, Godbehere S, Zlatkin I, Kim S, McCormick JJ, Amalfitano A. A new adenovirus based vaccine vector expressing an Eimeria tenella derived TLR agonist improves cellular immune responses to an antigenic target. Plos One. 5: e9579. PMID 20221448 DOI: 10.1371/Journal.Pone.0009579  0.623
2010 Appledorn DM, Dao KH, O'Reilly S, Maher VM, McCormick JJ. Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts. Bmc Cancer. 10: 13. PMID 20067638 DOI: 10.1186/1471-2407-10-13  0.635
2010 Seregin SS, Appledorn DM, Patial S, Bujold M, Nance W, Godbehere S, Parameswaran N, Amalfitano A. beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2. Virus Research. 147: 123-34. PMID 19896992 DOI: 10.1016/J.Virusres.2009.10.023  0.384
2009 Appledorn DM, Patial S, Godbehere S, Parameswaran N, Amalfitano A. TRIF, and TRIF-interacting TLRs differentially modulate several adenovirus vector-induced immune responses. Journal of Innate Immunity. 1: 376-88. PMID 20375595 DOI: 10.1159/000207194  0.457
2009 Seregin SS, Aldhamen YA, Appledorn DM, Schuldt NJ, McBride AJ, Bujold M, Godbehere SS, Amalfitano A. CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies. Gene Therapy. 16: 1245-59. PMID 19554032 DOI: 10.1038/Gt.2009.77  0.457
2009 Rathinam VA, Appledorn DM, Hoag KA, Amalfitano A, Mansfield LS. Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes. Infection and Immunity. 77: 2499-507. PMID 19332531 DOI: 10.1128/Iai.01562-08  0.354
2009 Seregin SS, Appledorn DM, McBride AJ, Schuldt NJ, Aldhamen YA, Voss T, Wei J, Bujold M, Nance W, Godbehere S, Amalfitano A. Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 685-96. PMID 19174760 DOI: 10.1038/Mt.2008.297  0.446
2009 Lito P, Mets BD, Appledorn DM, Maher VM, McCormick JJ. Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts. The Journal of Biological Chemistry. 284: 848-54. PMID 19008219 DOI: 10.1074/Jbc.M808045200  0.612
2008 Appledorn DM, Patial S, McBride A, Godbehere S, Van Rooijen N, Parameswaran N, Amalfitano A. Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo. Journal of Immunology (Baltimore, Md. : 1950). 181: 2134-44. PMID 18641352 DOI: 10.4049/Jimmunol.181.3.2134  0.457
2008 Appledorn DM, McBride A, Seregin S, Scott JM, Schuldt N, Kiang A, Godbehere S, Amalfitano A. Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectors. Gene Therapy. 15: 1606-17. PMID 18615115 DOI: 10.1038/Gt.2008.114  0.428
2008 Appledorn DM, Seregin S, Amalfitano A. Adenovirus vectors for renal-targeted gene delivery. Contributions to Nephrology. 159: 47-62. PMID 18391584 DOI: 10.1159/000125581  0.32
2008 Appledorn DM, Kiang A, McBride A, Jiang H, Seregin S, Scott JM, Stringer R, Kousa Y, Hoban M, Frank MM, Amalfitano A. Wild-type adenoviruses from groups A-F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent. Gene Therapy. 15: 885-901. PMID 18288208 DOI: 10.1038/Gt.2008.18  0.439
2008 Hartman ZC, Appledorn DM, Serra D, Glass O, Mendelson TB, Clay TM, Amalfitano A. Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system. Virology. 374: 453-67. PMID 18280530 DOI: 10.1016/J.Virol.2008.01.017  0.344
2008 Hartman ZC, Appledorn DM, Amalfitano A. Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications. Virus Research. 132: 1-14. PMID 18036698 DOI: 10.1016/J.Virusres.2007.10.005  0.437
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