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Dallas Flies, Ph.D. - Publications

Affiliations: 
2010 Johns Hopkins University, Baltimore, MD 
Area:
Immunology
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48/59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Prajapati K, Yan C, Yang Q, Arbitman S, Fitzgerald DP, Sharee S, Shaik J, Bosiacki J, Myers K, Paucarmayta A, Johnson DM, O'Neill T, Kundu S, Cusumano Z, Langermann S, ... ... Flies DB, et al. The FLRT3-UNC5B checkpoint pathway inhibits T cell-based cancer immunotherapies. Science Advances. 10: eadj4698. PMID 38427724 DOI: 10.1126/sciadv.adj4698  0.382
2023 Wang Q, He J, Flies DB, Luo L, Chen L. Author Correction: Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Scientific Reports. 13: 11603. PMID 37463928 DOI: 10.1038/s41598-023-37791-w  0.431
2021 Vijver SV, Singh A, Mommers-Elshof ETAM, Meeldijk J, Copeland R, Boon L, Langermann S, Flies D, Meyaard L, Ramos MIP. Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1. Frontiers in Immunology. 12: 733561. PMID 34691040 DOI: 10.3389/fimmu.2021.733561  0.314
2021 Ramos MIP, Tian L, de Ruiter EJ, Song C, Paucarmayta A, Singh A, Elshof E, Vijver SV, Shaik J, Bosiacki J, Cusumano Z, Jensen C, Willumsen N, Karsdal MA, Liu L, ... ... Flies D, et al. Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction. Elife. 10. PMID 34121658 DOI: 10.7554/eLife.62927  0.351
2019 Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, et al. PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. Science Translational Medicine. 11. PMID 31826980 DOI: 10.1126/Scitranslmed.Aax1159  0.508
2019 Wang J, Sun J, Liu LN, Flies DB, Nie X, Toki M, Zhang J, Song C, Zarr M, Zhou X, Han X, Archer KA, O'Neill T, Herbst RS, Boto AN, et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature Medicine. PMID 30833750 DOI: 10.1038/S41591-019-0374-X  0.603
2017 Wang Q, He J, Flies DB, Luo L, Chen L. Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Scientific Reports. 7: 6086. PMID 28729608 DOI: 10.1038/S41598-017-06410-W  0.568
2016 Flies DB, Higuchi T, Harris JC, Jha V, Gimotty PA, Adams SF. Immune checkpoint blockade reveals the stimulatory capacity of tumor-associated CD103(+) dendritic cells in late-stage ovarian cancer. Oncoimmunology. 5: e1185583. PMID 27622059 DOI: 10.1080/2162402X.2016.1185583  0.405
2015 Higuchi T, Flies DB, Marjon NA, Mantia-Smaldone G, Ronner L, Gimotty PA, Adams SF. CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer. Cancer Immunology Research. 3: 1257-68. PMID 26138335 DOI: 10.1158/2326-6066.Cir-15-0044  0.308
2015 Flies DB, Higuchi T, Chen L. Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens. Journal of Immunology (Baltimore, Md. : 1950). 194: 5294-304. PMID 25917101 DOI: 10.4049/Jimmunol.1402648  0.577
2014 Flies DB, Han X, Higuchi T, Zheng L, Sun J, Ye JJ, Chen L. Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity. The Journal of Clinical Investigation. 124: 1966-75. PMID 24743150 DOI: 10.1172/Jci74589  0.606
2013 Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nature Reviews. Immunology. 13: 227-42. PMID 23470321 DOI: 10.1038/Nri3405  0.509
2013 Chen L, Flies DB. Erratum: Molecular mechanisms of T cell co-stimulation and co-inhibition Nature Reviews Immunology. 13: 542-542. DOI: 10.1038/Nri3484  0.546
2011 Flies DB, Sandler BJ, Sznol M, Chen L. Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy. The Yale Journal of Biology and Medicine. 84: 409-21. PMID 22180678  0.522
2011 Flies DB, Wang S, Xu H, Chen L. Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models. Journal of Immunology (Baltimore, Md. : 1950). 187: 1537-41. PMID 21768399 DOI: 10.4049/Jimmunol.1100660  0.544
2011 Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L. B7-h2 is a costimulatory ligand for CD28 in human. Immunity. 34: 729-40. PMID 21530327 DOI: 10.1016/J.Immuni.2011.03.014  0.739
2010 Nguyen LT, Ciric B, Van Keulen VP, Rodriguez M, Pease LR, Tamada K, Flies DB, Chen L. Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Research. 70: 9528. PMID 21045150 DOI: 10.1158/0008-5472.Can-10-3461  0.471
2007 Flies DB, Chen L. The new B7s: playing a pivotal role in tumor immunity. Journal of Immunotherapy (Hagerstown, Md. : 1997). 30: 251-60. PMID 17414316 DOI: 10.1097/Cji.0B013E31802E085A  0.54
2007 Xu Y, Flies AS, Flies DB, Zhu G, Anand S, Flies SJ, Xu H, Anders RA, Hancock WW, Chen L, Tamada K. Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood. 109: 4097-104. PMID 17179227 DOI: 10.1182/Blood-2006-09-047332  0.701
2006 Flies DB, Chen L. Modulation of immune response by B7 family molecules in tumor microenvironments. Immunological Investigations. 35: 395-418. PMID 16916759 DOI: 10.1080/08820130600755017  0.479
2006 Anand S, Wang P, Yoshimura K, Choi IH, Hilliard A, Chen YH, Wang CR, Schulick R, Flies AS, Flies DB, Zhu G, Xu Y, Pardoll DM, Chen L, Tamada K. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. The Journal of Clinical Investigation. 116: 1045-51. PMID 16557300 DOI: 10.1172/Jci27083  0.679
2006 Drake CG, Kelleher C, Bruno T, Harris T, Flies D, Getnet D, Hipkiss E, Maris C, Grosso J. Blocking the regulatory T cell molecule LAG-3 augments in vivo anti-tumor immunity in an autochthonous model of prostate cancer Journal of Clinical Oncology. 24: 2573-2573. DOI: 10.1200/Jco.2006.24.18_Suppl.2573  0.552
2005 Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, Rietz C, Flies DB, Lau JS, Zhu G, Tamada K, Chen L. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Research. 65: 1089-96. PMID 15705911  0.598
2005 Aalamian-Mattheis M, Wang J, Jalla S, Hipkiss E, Flies D, Harris T, Drake CG, Pardoll DM, Fuchs EJ. 245: Regression of Prostate Cancer in Animals Treated with Donor Lymphocyte Infusion (DLI) and a Cell Based Tumor Vaccine after Conditioning with a Single Dose of Cyclophosphamide Journal of Urology. 173: 67-67. DOI: 10.1016/S0022-5347(18)34510-5  0.304
2004 Luo L, Chapoval AI, Flies DB, Zhu G, Hirano F, Wang S, Lau JS, Dong H, Tamada K, Flies AS, Liu Y, Chen L. B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 5445-50. PMID 15494491 DOI: 10.4049/Jimmunol.173.9.5445  0.645
2004 Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Levitsky HI, Powell JD, Pardoll DM, Drake CG, Vignali DA. Role of LAG-3 in regulatory T cells. Immunity. 21: 503-13. PMID 15485628 DOI: 10.1016/J.Immuni.2004.08.010  0.533
2004 Radhakrishnan S, Nguyen LT, Ciric B, Flies D, Van Keulen VP, Tamada K, Chen L, Rodriguez M, Pease LR. Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Research. 64: 4965-72. PMID 15256470 DOI: 10.1158/0008-5472.Can-03-3025  0.618
2004 Dong H, Zhu G, Tamada K, Flies DB, van Deursen JM, Chen L. B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity. 20: 327-36. PMID 15030776 DOI: 10.1016/S1074-7613(04)00050-0  0.59
2004 Wilcox RA, Tamada K, Flies DB, Zhu G, Chapoval AI, Blazar BR, Kast WM, Chen L. Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo. Blood. 103: 177-84. PMID 12969968 DOI: 10.1182/Blood-2003-06-2184  0.611
2003 Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L. Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. Journal of Immunology (Baltimore, Md. : 1950). 171: 4650-4. PMID 14568939 DOI: 10.4049/Jimmunol.171.9.4650  0.539
2003 Strome SE, Dong H, Tamura H, Voss SG, Flies DB, Tamada K, Salomao D, Cheville J, Hirano F, Lin W, Kasperbauer JL, Ballman KV, Chen L. B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Research. 63: 6501-5. PMID 14559843  0.597
2003 Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity. 18: 849-61. PMID 12818165 DOI: 10.1016/S1074-7613(03)00152-3  0.618
2003 Flies DB, Chen L. A simple and rapid vortex method for preparing antigen/adjuvant emulsions for immunization. Journal of Immunological Methods. 276: 239-42. PMID 12738377 DOI: 10.1016/S0022-1759(03)00081-4  0.413
2003 Wang S, Bajorath J, Flies DB, Dong H, Honjo T, Chen L. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. The Journal of Experimental Medicine. 197: 1083-91. PMID 12719480 DOI: 10.1084/Jem.20021752  0.517
2003 Dong H, Strome SE, Matteson EL, Moder KG, Flies DB, Zhu G, Tamura H, Driscoll CLW, Chen L. Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis Journal of Clinical Investigation. 111: 363-370. PMID 12569162 DOI: 10.1172/Jci16015  0.62
2002 Wilcox RA, Flies DB, Wang H, Tamada K, Johnson AJ, Pease LR, Rodriguez M, Guo Y, Chen L. Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy. Cancer Research. 62: 4413-8. PMID 12154048  0.534
2002 Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nature Medicine. 8: 793-800. PMID 12091876 DOI: 10.1038/Nm730  0.634
2002 Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB, Tamada K, Mittler RS, Tsuchiya H, Pardoll DM, Chen L. Cutting edge: Expression of functional CD137 receptor by dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 168: 4262-7. PMID 11970964 DOI: 10.4049/Jimmunol.168.9.4262  0.574
2002 Strome SE, Voss S, Wilcox R, Wakefield TL, Tamada K, Flies D, Chapoval A, Lu J, Kasperbauer JL, Padley D, Vile R, Gastineau D, Wettstein P, Chen L. Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Research. 62: 1884-9. PMID 11912169  0.516
2002 Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, Strome SE, Pease LR, Chen L. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. The Journal of Clinical Investigation. 109: 651-9. PMID 11877473 DOI: 10.1172/Jci14184  0.528
2002 Strome SE, Martin E, Flies D, Khurana D, Salomao D, Tamada K, Chapoval AI, Kasperbauer JL, Olsen KD, Chen L. Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 126: 180-7. PMID 11870350 DOI: 10.1067/Mhn.2002.122263  0.557
2002 Tamada K, Tamura H, Flies D, Fu YX, Celis E, Pease LR, Blazar BR, Chen L. Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. The Journal of Clinical Investigation. 109: 549-57. PMID 11854328 DOI: 10.1172/JCI13604  0.616
2002 Tamada K, Tamura H, Flies D, Fu YX, Celis E, Pease LR, Blazar BR, Chen L. Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease Journal of Clinical Investigation. 109: 549-557. DOI: 10.1172/Jci200213604  0.651
2001 Zhu G, Flies DB, Tamada K, Sun Y, Rodriguez M, Fu YX, Chen L. Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 167: 2671-6. PMID 11509610 DOI: 10.4049/Jimmunol.167.5.2671  0.592
2001 Tamura H, Dong H, Zhu G, Sica GL, Flies DB, Tamada K, Chen L. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood. 97: 1809-16. PMID 11238124 DOI: 10.1182/Blood.V97.6.1809  0.652
2001 Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nature Immunology. 2: 269-74. PMID 11224528 DOI: 10.1038/85339  0.651
2000 Strome SE, Martin B, Flies D, Tamada K, Chapoval AI, Sargent DJ, Shu S, Chen L. Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma. Journal of Immunotherapy (Hagerstown, Md. : 1997). 23: 430-7. PMID 10916752 DOI: 10.1097/00002371-200007000-00006  0.635
2000 Tamada K, Shimozaki K, Chapoval AI, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu YX, Nagata S, Ni J, Chen L. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nature Medicine. 6: 283-9. PMID 10700230 DOI: 10.1038/73136  0.641
Low-probability matches (unlikely to be authored by this person)
2022 Horn LA, Chariou PL, Gameiro SR, Qin H, Iida M, Fousek K, Meyer TJ, Cam M, Flies D, Langermann S, Schlom J, Palena C. Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1-mediated tumor eradication. The Journal of Clinical Investigation. PMID 35230974 DOI: 10.1172/JCI155148  0.299
2023 Aung TN, Gavrielatou N, Vathiotis IA, Fernandez AI, Shafi S, Yaghoobi V, Burela S, MacNeil T, Ahmed FS, Myint H, Flies DB, Langermann S, Rimm DL. Quantitative, Spatially Defined Expression of Leukocyte-associated Immunoglobulin-like Receptor in Non-small Cell Lung Cancer. Cancer Research Communications. 3: 471-482. PMID 36960400 DOI: 10.1158/2767-9764.CRC-22-0334  0.275
2023 Flies DB, Langermann S, Jensen C, Karsdal MA, Willumsen N. Regulation of tumor immunity and immunotherapy by the tumor collagen extracellular matrix. Frontiers in Immunology. 14: 1199513. PMID 37662958 DOI: 10.3389/fimmu.2023.1199513  0.268
2023 Lovewell RR, Hong J, Kundu S, Fielder CM, Hu Q, Kim KW, Ramsey HE, Gorska AE, Fuller LS, Tian L, Kothari P, Paucarmayta A, Mason EF, Meza I, Manzanarez Y, ... ... Flies DB, et al. LAIR-1 agonism as a therapy for acute myeloid leukemia. The Journal of Clinical Investigation. 133. PMID 37966113 DOI: 10.1172/JCI169519  0.242
2014 Higuchi T, Flies D, Mantia-Smaldone G, Ronner P, Alldredge J, Orsulic S, Adams S. PARP inhibition synergizes with anti-CTLA-4 immune therapy to promote rejection of peritoneal tumors in mouse models of ovarian cancer Gynecologic Oncology. 133: 115-116. DOI: 10.1016/J.Ygyno.2014.03.305  0.222
2024 Singh A, Mommers-Elshof ETAM, Vijver SV, Jansen JHM, Gonder S, Lebbink RJ, Bihan D, Farndale RW, Boon L, Langermann S, Leusen JHW, Flies D, Meyaard L, Pascoal Ramos MI. Leukocyte-associated immunoglobulin-like receptor-1 blockade in combination with programmed death-ligand 1 targeting therapy mediates increased tumour control in mice. Cancer Immunology, Immunotherapy : Cii. 73: 16. PMID 38236251 DOI: 10.1007/s00262-023-03600-6  0.219
2005 Drake CG, Doody AD, Mihalyo MA, Huang CT, Kelleher E, Ravi S, Hipkiss EL, Flies DB, Kennedy EP, Long M, McGary PW, Coryell L, Nelson WG, Pardoll DM, Adler AJ. Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer Cell. 7: 239-49. PMID 15766662 DOI: 10.1016/j.ccr.2005.01.027  0.161
2020 Adams SF, Grimm AJ, Chiang CL, Mookerjee A, Flies D, Jean S, McCann GA, Michaux J, Pak H, Huber F, Neal C, Dangaj D, Bassani-Sternberg M, Rusakiewicz S, Facciabene A, et al. Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes. Journal For Immunotherapy of Cancer. 8. PMID 32817208 DOI: 10.1136/Jitc-2020-000875  0.142
2013 Jackson CM, Flies DB, Mosse CA, Parwani A, Hipkiss EL, Drake CG. Strain-specific induction of experimental autoimmune prostatitis (EAP) in mice. The Prostate. 73: 651-6. PMID 23129407 DOI: 10.1002/Pros.22606  0.073
2014 Alldredge J, Flies D, Higuchi T, Ma T, Adams SF. Impaired interleukin-10 signaling and ovarian cancer growth in the peritoneal cavity. Journal of Clinical Oncology. 32: e22094-e22094. DOI: 10.1200/JCO.2014.32.15_SUPPL.E22094  0.067
2016 Ager C, Reilley M, Nicholas C, Bartkowiak T, Jaiswal A, Curran M, Albershardt TC, Bajaj A, Archer JF, Reeves RS, Ngo LY, Berglund P, ter Meulen J, Denis C, Ghadially H, ... ... Flies DB, et al. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two Journal For Immunotherapy of Cancer. 4. DOI: 10.1186/S40425-016-0173-6  0.062
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