E John Wherry - Publications

Affiliations: 
Immunology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Immunology, Cell Biology, Virology Biology

89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ. Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. Immunity. PMID 27496729 DOI: 10.1016/j.immuni.2016.07.008  0.8
2016 Barnett BE, Staupe RP, Odorizzi PM, Palko O, Tomov VT, Mahan AE, Gunn B, Chen D, Paley MA, Alter G, Reiner SL, Lauer GM, Teijaro JR, Wherry EJ. Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 27430722 DOI: 10.4049/jimmunol.1500368  0.8
2016 Nice TJ, Osborne LC, Tomov VT, Artis D, Wherry EJ, Virgin HW. Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity. Plos Pathogens. 12: e1005684. PMID 27327515 DOI: 10.1371/journal.ppat.1005684  0.48
2016 Riou C, Strickland N, Soares AP, Corleis B, Kwon DS, Wherry EJ, Wilkinson RJ, Burgers WA. HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis-Specific CD4+ T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 26927799 DOI: 10.4049/jimmunol.1502094  0.64
2015 Pauken KE, Wherry EJ. SnapShot: T Cell Exhaustion. Cell. 163: 1038-1038.e1. PMID 26544946 DOI: 10.1016/j.cell.2015.10.054  0.64
2015 Rood JE, Rao S, Paessler M, Kreiger PA, Chu N, Stelekati E, Wherry EJ, Behrens EM. ST2 contributes to T cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice. Blood. PMID 26518437 DOI: 10.1182/blood-2015-07-659813  0.64
2015 Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, et al. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. Plos Pathogens. 11: e1005177. PMID 26485519 DOI: 10.1371/journal.ppat.1005177  0.64
2015 Lee JE, Walsh MC, Hoehn KL, James DE, Wherry EJ, Choi Y. Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses. Plos One. 10: e0137776. PMID 26367121 DOI: 10.1371/journal.pone.0137776  0.64
2015 Crosby EJ, Clark M, Novais FO, Wherry EJ, Scott P. Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbate Disease in Mice Coinfected with Leishmania major. Journal of Immunology (Baltimore, Md. : 1950). PMID 26290604 DOI: 10.4049/jimmunol.1500855  0.64
2015 Beiting DP, Hidano S, Baggs JE, Geskes JM, Fang Q, Wherry EJ, Hunter CA, Roos DS, Cherry S. The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii. Plos Biology. 13: e1002200. PMID 26196739 DOI: 10.1371/journal.pbio.1002200  0.64
2015 Odorizzi PM, Pauken KE, Paley MA, Sharpe A, Wherry EJ. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells. The Journal of Experimental Medicine. 212: 1125-37. PMID 26034050 DOI: 10.1084/jem.20142237  0.68
2015 Pombo C, Wherry EJ, Gostick E, Price DA, Betts MR. Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers. The Journal of Infectious Diseases. PMID 25883386 DOI: 10.1093/infdis/jiv226  0.64
2015 Schlie K, Westerback A, DeVorkin L, Hughson LR, Brandon JM, MacPherson S, Gadawski I, Townsend KN, Poon VI, Elrick MA, Côté HCF, Abraham N, Wherry EJ, Mizushima N, Lum JJ. Survival of effector CD8+ T cells during influenza infection is dependent on autophagy Journal of Immunology. 194: 4277-4286. PMID 25833396 DOI: 10.4049/jimmunol.1402571  0.64
2015 Gandhi SJ, Minn AJ, Vonderheide RH, Wherry EJ, Hahn SM, Maity A. Awakening the immune system with radiation: Optimal dose and fractionation. Cancer Letters. PMID 25799953 DOI: 10.1016/j.canlet.2015.03.024  0.64
2015 Pauken KE, Wherry EJ. Overcoming T cell exhaustion in infection and cancer. Trends in Immunology. 36: 265-76. PMID 25797516 DOI: 10.1016/j.it.2015.02.008  0.64
2015 Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, ... ... Wherry EJ, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature. 520: 373-7. PMID 25754329 DOI: 10.1038/nature14292  0.64
2015 Winograd R, Byrne KT, Evans RA, Odorizzi PM, Meyer AR, Bajor DL, Clendenin C, Stanger BZ, Furth EE, Wherry EJ, Vonderheide RH. Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma. Cancer Immunology Research. 3: 399-411. PMID 25678581 DOI: 10.1158/2326-6066.CIR-14-0215  0.64
2015 Kahan SM, Wherry EJ, Zajac AJ. T cell exhaustion during persistent viral infections. Virology. 479: 180-93. PMID 25620767 DOI: 10.1016/j.virol.2014.12.033  0.64
2015 Penaloza-MacMaster P, Barber DL, Wherry EJ, Provine NM, Teigler JE, Parenteau L, Blackmore S, Borducchi EN, Larocca RA, Yates KB, Shen H, Haining WN, Sommerstein R, Pinschewer DD, Ahmed R, et al. Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection. Science (New York, N.Y.). 347: 278-82. PMID 25593185 DOI: 10.1126/science.aaa2148  0.64
2014 Pauken KE, Wherry EJ. TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit. Cancer Cell. 26: 785-7. PMID 25490444 DOI: 10.1016/j.ccell.2014.11.016  0.64
2014 Chang JT, Wherry EJ, Goldrath AW. Molecular regulation of effector and memory T cell differentiation. Nature Immunology. 15: 1104-15. PMID 25396352 DOI: 10.1038/ni.3031  0.64
2014 Herati RS, Reuter MA, Dolfi DV, Mansfield KD, Aung H, Badwan OZ, Kurupati RK, Kannan S, Ertl H, Schmader KE, Betts MR, Canaday DH, Wherry EJ. Circulating CXCR5+PD-1+response predicts influenza vaccine antibody responses in young adults but not elderly adults Journal of Immunology. 193: 3528-3537. PMID 25172499 DOI: 10.4049/jimmunol.1302503  0.64
2014 Osborne LC, Monticelli LA, Nice TJ, Sutherland TE, Siracusa MC, Hepworth MR, Tomov VT, Kobuley D, Tran SV, Bittinger K, Bailey AG, Laughlin AL, Boucher JL, Wherry EJ, Bushman FD, et al. Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation. Science (New York, N.Y.). 345: 578-82. PMID 25082704 DOI: 10.1126/science.1256942  0.64
2014 Moon EK, Wang LC, Dolfi DV, Wilson CB, Ranganathan R, Sun J, Kapoor V, Scholler J, Puré E, Milone MC, June CH, Riley JL, Wherry EJ, Albelda SM. Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 4262-73. PMID 24919573 DOI: 10.1158/1078-0432.CCR-13-2627  0.64
2014 Stelekati E, Shin H, Doering TA, Dolfi DV, Ziegler CG, Beiting DP, Dawson L, Liboon J, Wolski D, Ali MA, Katsikis PD, Shen H, Roos DS, Haining WN, Lauer GM, ... Wherry EJ, et al. Bystander chronic infection negatively impacts development of CD8(+) T cell memory. Immunity. 40: 801-13. PMID 24837104 DOI: 10.1016/j.immuni.2014.04.010  0.64
2014 Barnett LG, Simkins HMA, Barnett BE, Korn LL, Johnson AL, Wherry EJ, Wu GF, Laufer TM. B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation Journal of Immunology. 192: 3607-3617. PMID 24646739 DOI: 10.4049/jimmunol.1301284  0.64
2014 Schadler KL, Crosby EJ, Zhou AY, Bhang DH, Braunstein L, Baek KH, Crawford D, Crawford A, Angelosanto J, Wherry EJ, Ryeom S. Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1. Cancer Research. 74: 2171-81. PMID 24590059 DOI: 10.1158/0008-5472.CAN-13-0094  0.64
2014 Kurachi M, Barnitz RA, Yosef N, Odorizzi PM, DiIorio MA, Lemieux ME, Yates K, Godec J, Klatt MG, Regev A, Wherry EJ, Haining WN. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nature Immunology. 15: 373-83. PMID 24584090 DOI: 10.1038/ni.2834  0.64
2014 Lee J, Walsh MC, Hoehn KL, James DE, Wherry EJ, Choi Y. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. Journal of Immunology (Baltimore, Md. : 1950). 192: 3190-9. PMID 24567531 DOI: 10.4049/jimmunol.1302985  0.64
2014 Crawford A, Angelosanto JM, Kao C, Doering TA, Odorizzi PM, Barnett BE, Wherry EJ. Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection. Immunity. 40: 289-302. PMID 24530057 DOI: 10.1016/j.immuni.2014.01.005  0.64
2014 Lagor WR, Fields DW, Bauer RC, Crawford A, Abt MC, Artis D, Wherry EJ, Rader DJ. Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis. Atherosclerosis. 233: 234-41. PMID 24529150 DOI: 10.1016/j.atherosclerosis.2013.12.043  0.64
2014 Beiting DP, Peixoto L, Akopyants NS, Beverley SM, Wherry EJ, Christian DA, Hunter CA, Brodsky IE, Roos DS. Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. Plos One. 9: e88398. PMID 24505488 DOI: 10.1371/journal.pone.0088398  0.64
2014 Kroy DC, Ciuffreda D, Cooperrider JH, Tomlinson M, Hauck GD, Aneja J, Berger C, Wolski D, Carrington M, Wherry EJ, Chung RT, Tanabe KK, Elias N, Freeman GJ, de Kruyff RH, et al. Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology. 146: 550-61. PMID 24148617 DOI: 10.1053/j.gastro.2013.10.022  0.64
2014 Turner DL, Bickham KL, Thome JJ, Kim CY, D'Ovidio F, Wherry EJ, Farber DL. Lung niches for the generation and maintenance of tissue-resident memory T cells. Mucosal Immunology. 7: 501-10. PMID 24064670 DOI: 10.1038/mi.2013.67  0.64
2014 Mays LE, Wang L, Lin J, Bell P, Crawford A, Wherry EJ, Wilson JM. AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 28-41. PMID 23778424 DOI: 10.1038/mt.2013.134  0.64
2013 Parzych EM, DiMenna LJ, Latimer BP, Small JC, Kannan S, Manson B, Lasaro MO, Wherry EJ, Ertl HC. Influenza virus specific CD8⁺ T cells exacerbate infection following high dose influenza challenge of aged mice. Biomed Research International. 2013: 876314. PMID 24187666 DOI: 10.1155/2013/876314  0.64
2013 Dolfi DV, Mansfield KD, Kurupati RK, Kannan S, Doyle SA, Ertl HC, Schmader KE, Wherry EJ. Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans. Plos One. 8: e77164. PMID 24155927 DOI: 10.1371/journal.pone.0077164  0.64
2013 Saenz SA, Siracusa MC, Monticelli LA, Ziegler CG, Kim BS, Brestoff JR, Peterson LW, Wherry EJ, Goldrath AW, Bhandoola A, Artis D. IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. The Journal of Experimental Medicine. 210: 1823-37. PMID 23960191 DOI: 10.1084/jem.20122332  0.64
2013 Buchlis G, Odorizzi P, Soto PC, Pearce OM, Hui DJ, Jordan MS, Varki A, Wherry EJ, High KA. Enhanced T cell function in a mouse model of human glycosylation. Journal of Immunology (Baltimore, Md. : 1950). 191: 228-37. PMID 23709682 DOI: 10.4049/jimmunol.1202905  0.64
2013 Bedoya F, Cheng GS, Leibow A, Zakhary N, Weissler K, Garcia V, Aitken M, Kropf E, Garlick DS, Wherry EJ, Erikson J, Caton AJ. Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice. Journal of Immunology (Baltimore, Md. : 1950). 190: 6115-25. PMID 23667113 DOI: 10.4049/jimmunol.1203302  0.64
2013 Gracias DT, Stelekati E, Hope JL, Boesteanu AC, Doering TA, Norton J, Mueller YM, Fraietta JA, Wherry EJ, Turner M, Katsikis PD. The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nature Immunology. 14: 593-602. PMID 23603793 DOI: 10.1038/ni.2576  0.64
2013 Tomov VT, Osborne LC, Dolfi DV, Sonnenberg GF, Monticelli LA, Mansfield K, Virgin HW, Artis D, Wherry EJ. Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses. Journal of Virology. 87: 7015-31. PMID 23596300 DOI: 10.1128/JVI.03389-12  0.64
2013 Laidlaw BJ, Decman V, Ali MA, Abt MC, Wolf AI, Monticelli LA, Mozdzanowska K, Angelosanto JM, Artis D, Erikson J, Wherry EJ. Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity. Plos Pathogens. 9: e1003207. PMID 23516357 DOI: 10.1371/journal.ppat.1003207  0.64
2013 Jackson SR, Berrien-Elliott MM, Meyer JM, Wherry EJ, Teague RM. CD8+ T cell exhaustion during persistent viral infection is regulated independently of the virus-specific T cell receptor. Immunological Investigations. 42: 204-20. PMID 23461613 DOI: 10.3109/08820139.2012.751397  0.64
2013 McLane LM, Banerjee PP, Cosma GL, Makedonas G, Wherry EJ, Orange JS, Betts MR. Differential localization of T-bet and Eomes in CD8 T cell memory populations Journal of Immunology. 190: 3207-3215. PMID 23455505 DOI: 10.4049/jimmunol.1201556  0.64
2013 Dolfi DV, Mansfield KD, Polley AM, Doyle SA, Freeman GJ, Pircher H, Schmader KE, Wherry EJ. Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans. Journal of Leukocyte Biology. 93: 825-36. PMID 23440501 DOI: 10.1189/jlb.0912438  0.64
2013 Paley MA, Gordon SM, Bikoff EK, Robertson EJ, Wherry EJ, Reiner SL. Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes. Journal of Leukocyte Biology. 93: 307-15. PMID 23192430 DOI: 10.1189/jlb.0812400  0.64
2012 Paley MA, Kroy DC, Odorizzi PM, Johnnidis JB, Dolfi DV, Barnett BE, Bikoff EK, Robertson EJ, Lauer GM, Reiner SL, Wherry EJ. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science (New York, N.Y.). 338: 1220-5. PMID 23197535 DOI: 10.1126/science.1229620  0.64
2012 Doering TA, Crawford A, Angelosanto JM, Paley MA, Ziegler CG, Wherry EJ. Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory. Immunity. 37: 1130-44. PMID 23159438 DOI: 10.1016/j.immuni.2012.08.021  0.8
2012 Abt MC, Osborne LC, Monticelli LA, Doering TA, Alenghat T, Sonnenberg GF, Paley MA, Antenus M, Williams KL, Erikson J, Wherry EJ, Artis D. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity. 37: 158-70. PMID 22705104 DOI: 10.1016/j.immuni.2012.04.011  0.64
2012 Walsh KB, Teijaro JR, Zuniga EI, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host & Microbe. 11: 643-53. PMID 22704624 DOI: 10.1016/j.chom.2012.04.016  0.64
2012 Angelosanto JM, Blackburn SD, Crawford A, Wherry EJ. Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection. Journal of Virology. 86: 8161-70. PMID 22623779 DOI: 10.1128/JVI.00889-12  0.64
2012 Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. Journal of Immunology (Baltimore, Md. : 1950). 188: 4866-75. PMID 22504644 DOI: 10.4049/jimmunol.1200402  0.64
2012 Harris JE, Harris TH, Weninger W, Wherry EJ, Hunter CA, Turka LA. A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin. The Journal of Investigative Dermatology. 132: 1869-76. PMID 22297636 DOI: 10.1038/jid.2011.463  0.64
2012 Youngblood B, Wherry EJ, Ahmed R. Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells. Current Opinion in Hiv and Aids. 7: 50-7. PMID 22134341 DOI: 10.1097/COH.0b013e32834ddcf2  0.64
2012 Iyer SS, Chatraw JH, Tan WG, Wherry EJ, Becker TC, Ahmed R, Kapasi ZF. Protein energy malnutrition impairs homeostatic proliferation of memory CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 77-84. PMID 22116826 DOI: 10.4049/jimmunol.1004027  0.64
2011 Teijaro JR, Turner D, Pham Q, Wherry EJ, Lefrançois L, Farber DL. Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. Journal of Immunology (Baltimore, Md. : 1950). 187: 5510-4. PMID 22058417 DOI: 10.4049/jimmunol.1102243  0.64
2011 Monticelli LA, Sonnenberg GF, Abt MC, Alenghat T, Ziegler CG, Doering TA, Angelosanto JM, Laidlaw BJ, Yang CY, Sathaliyawala T, Kubota M, Turner D, Diamond JM, Goldrath AW, Farber DL, ... ... Wherry EJ, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nature Immunology. 12: 1045-54. PMID 21946417 DOI: 10.1031/ni.2131  0.64
2011 Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF, et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature. 477: 229-33. PMID 21841801 DOI: 10.1038/nature10329  0.64
2011 Crawford A, Angelosanto JM, Nadwodny KL, Blackburn SD, Wherry EJ. A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection. Plos Pathogens. 7: e1002098. PMID 21814510 DOI: 10.1371/journal.ppat.1002098  0.56
2011 Kao C, Oestreich KJ, Paley MA, Crawford A, Angelosanto JM, Ali MA, Intlekofer AM, Boss JM, Reiner SL, Weinmann AS, Wherry EJ. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nature Immunology. 12: 663-71. PMID 21623380 DOI: 10.1038/ni.2046  0.64
2011 Zediak VP, Wherry EJ, Berger SL. The contribution of epigenetic memory to immunologic memory. Current Opinion in Genetics & Development. 21: 154-9. PMID 21330128 DOI: 10.1016/j.gde.2011.01.016  0.64
2011 Zediak VP, Johnnidis JB, Wherry EJ, Berger SL. Cutting edge: persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status. Journal of Immunology (Baltimore, Md. : 1950). 186: 2705-9. PMID 21278341 DOI: 10.4049/jimmunol.1003741  0.64
2011 Rahman AH, Zhang R, Blosser CD, Hou B, Defranco AL, Maltzman JS, Wherry EJ, Turka LA. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood. 117: 3123-30. PMID 21233312 DOI: 10.1182/blood-2010-11-318485  0.64
2010 Banerjee A, Gordon SM, Intlekofer AM, Paley MA, Mooney EC, Lindsten T, Wherry EJ, Reiner SL. Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. Journal of Immunology (Baltimore, Md. : 1950). 185: 4988-92. PMID 20935204 DOI: 10.4049/jimmunol.1002042  0.64
2010 Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S, Russell K, Toth I, Piechocka-Trocha A, Dolfi D, Angelosanto J, ... ... Wherry EJ, et al. Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nature Medicine. 16: 1147-51. PMID 20890291 DOI: 10.1038/nm.2232  0.64
2010 Wiehagen KR, Corbo E, Schmidt M, Shin H, Wherry EJ, Maltzman JS. Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells Blood. 116: 5560-5570. PMID 20884806 DOI: 10.1182/blood-2010-06-292458  0.64
2010 Smith-Garvin JE, Burns JC, Gohil M, Zou T, Kim JS, Maltzman JS, Wherry EJ, Koretzky GA, Jordan MS. T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool. Blood. 116: 5548-59. PMID 20847203 DOI: 10.1182/blood-2010-06-292748  0.64
2010 Paley MA, Wherry EJ. TCF-1 flips the switch on Eomes. Immunity. 33: 145-7. PMID 20732636 DOI: 10.1016/j.immuni.2010.08.008  0.8
2010 Brown KE, Freeman GJ, Wherry EJ, Sharpe AH. Role of PD-1 in regulating acute infections. Current Opinion in Immunology. 22: 397-401. PMID 20427170 DOI: 10.1016/j.coi.2010.03.007  0.64
2010 Makedonas G, Hutnick N, Haney D, Amick AC, Gardner J, Cosma G, Hersperger AR, Dolfi D, Wherry EJ, Ferrari G, Betts MR. Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. Plos Pathogens. 6: e1000798. PMID 20221423 DOI: 10.1371/journal.ppat.1000798  0.64
2010 Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, Akondy R, Wang J, Casey KA, Barber DL, Kawamura KS, Fraser KA, Webby RJ, Brinkmann V, Butcher EC, Newell KA, et al. Dynamic T cell migration program provides resident memory within intestinal epithelium. The Journal of Experimental Medicine. 207: 553-64. PMID 20156972 DOI: 10.1084/jem.20090858  0.64
2010 Blackburn SD, Crawford A, Shin H, Polley A, Freeman GJ, Wherry EJ. Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion. Journal of Virology. 84: 2078-89. PMID 19955307 DOI: 10.1128/JVI.01579-09  0.96
2009 Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, Wherry EJ. A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity. 31: 309-20. PMID 19664943 DOI: 10.1016/j.immuni.2009.06.019  0.64
2009 Virgin HW, Wherry EJ, Ahmed R. Redefining chronic viral infection. Cell. 138: 30-50. PMID 19596234 DOI: 10.1016/j.cell.2009.06.036  0.76
2009 Blattman JN, Wherry EJ, Ha SJ, van der Most RG, Ahmed R. Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. Journal of Virology. 83: 4386-94. PMID 19211743 DOI: 10.1128/JVI.02524-08  0.64
2009 Wilson EH, Harris TH, Mrass P, John B, Tait ED, Wu GF, Pepper M, Wherry EJ, Dzierzinski F, Roos D, Haydon PG, Laufer TM, Weninger W, Hunter CA. Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers. Immunity. 30: 300-11. PMID 19167248 DOI: 10.1016/j.immuni.2008.12.013  0.64
2009 Wolf AI, Buehler D, Hensley SE, Cavanagh LL, Wherry EJ, Kastner P, Chan S, Weninger W. Plasmacytoid dendritic cells are dispensable during primary influenza virus infection. Journal of Immunology (Baltimore, Md. : 1950). 182: 871-9. PMID 19124730  0.64
2009 Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DA, Wherry EJ. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nature Immunology. 10: 29-37. PMID 19043418 DOI: 10.1038/ni.1679  0.64
2008 Blackburn SD, Shin H, Freeman GJ, Wherry EJ. Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade. Proceedings of the National Academy of Sciences of the United States of America. 105: 15016-21. PMID 18809920 DOI: 10.1073/pnas.0801497105  0.96
2008 Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, et al. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 1859-68. PMID 18641323  0.64
2008 Intlekofer AM, Banerjee A, Takemoto N, Gordon SM, Dejong CS, Shin H, Hunter CA, Wherry EJ, Lindsten T, Reiner SL. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science (New York, N.Y.). 321: 408-11. PMID 18635804 DOI: 10.1126/science.1159806  0.64
2008 Chatraw JH, Wherry EJ, Ahmed R, Kapasi ZF. Diminished primary CD8 T cell response to viral infection during protein energy malnutrition in mice is due to changes in microenvironment and low numbers of viral-specific CD8 T cell precursors. The Journal of Nutrition. 138: 806-12. PMID 18356339  0.76
2008 Ha SJ, Mueller SN, Wherry EJ, Barber DL, Aubert RD, Sharpe AH, Freeman GJ, Ahmed R. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. The Journal of Experimental Medicine. 205: 543-55. PMID 18332181 DOI: 10.1084/jem.20071949  0.64
2008 Lasaro MO, Tatsis N, Hensley SE, Whitbeck JC, Lin SW, Rux JJ, Wherry EJ, Cohen GH, Eisenberg RJ, Ertl HC. Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses. Nature Medicine. 14: 205-12. PMID 18193057 DOI: 10.1038/nm1704  0.64
2007 Sarkar S, Teichgräber V, Kalia V, Polley A, Masopust D, Harrington LE, Ahmed R, Wherry EJ. Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. Journal of Immunology (Baltimore, Md. : 1950). 179: 6704-14. PMID 17982060  0.64
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2007 Shin H, Blackburn SD, Blattman JN, Wherry EJ. Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection. The Journal of Experimental Medicine. 204: 941-9. PMID 17420267 DOI: 10.1084/jem.20061937  0.64
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