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Ryan E. Temel - Publications

Affiliations: 
Molecular Pathology Wake Forest University, Winston-Salem, NC, United States 
Area:
Pathology, Cell Biology
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ye D, Wu C, Cai L, Howatt DA, Liang CL, Katsumata Y, Mullick AE, Temel RE, Danser AHJ, Daugherty A, Lu HS. Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice. Global Translational Medicine. 2. PMID 37293374 DOI: 10.36922/gtm.288  0.419
2021 Lang JM, Sedgeman LR, Cai L, Layne JD, Wang Z, Pan C, Lee R, Temel RE, Lusis AJ. Dietary and Pharmacologic Manipulations of Host Lipids and Their Interaction With the Gut Microbiome in Non-human Primates. Frontiers in Medicine. 8: 646710. PMID 34513856 DOI: 10.3389/fmed.2021.646710  0.411
2021 Gnanaguru G, Wagschal A, Oh J, Saez-Torres KL, Li T, Temel RE, Kleinman ME, Näär AM, D'Amore PA. Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33744470 DOI: 10.1016/j.ymthe.2021.03.014  0.358
2021 Gatineau E, Arthur G, Poupeau A, Nichols K, Spear B, Shelman N, Graf GA, Temel RE, Yiannikouris FB. The Prorenin Receptor and its Soluble Form Contribute to Lipid Homeostasis. American Journal of Physiology. Endocrinology and Metabolism. PMID 33459178 DOI: 10.1152/ajpendo.00135.2020  0.444
2020 Ito M, Ye X, Wang Q, Guo L, Hao D, Howatt D, Daugherty A, Cai L, Temel R, Li XA. SR-BI (Scavenger Receptor BI), Not LDL (Low-Density Lipoprotein) Receptor, Mediates Adrenal Stress Response. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314506. PMID 32522007 DOI: 10.1161/Atvbaha.120.314506  0.536
2020 Pathak P, Helsley RN, Brown AL, Buffa JA, Choucair I, Nemet I, Baleanu Gogonea C, Gogonea V, Wang Z, Garcia-Garcia JC, Cai L, Temel RE, Sangwan N, Hazen SL, Brown JM. Small Molecule Inhibition of Gut Microbial Choline Trimethylamine Lyase Activity Alters Host Cholesterol and Bile Acid Metabolism. American Journal of Physiology. Heart and Circulatory Physiology. PMID 32330092 DOI: 10.1152/Ajpheart.00584.2019  0.484
2019 Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, ... ... Temel RE, et al. The long noncoding RNA CHROME regulates cholesterol homeostasis in primates. Nature Metabolism. 1: 98-110. PMID 32694807 DOI: 10.1038/s42255-018-0004-9  0.404
2019 Lifsey HC, Kaur R, Thompson BH, Bennett L, Temel RE, Graf GA. Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine. The Journal of Nutritional Biochemistry. 76: 108263. PMID 31759199 DOI: 10.1016/J.Jnutbio.2019.108263  0.605
2019 Li J, Pijut SS, Wang Y, Ji A, Kaur R, Temel RE, van der Westhuyzen DR, Graf GA. Simultaneous Determination of Biliary and Intestinal Cholesterol Secretion Reveals That CETP (Cholesteryl Ester Transfer Protein) Alters Elimination Route in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119312952. PMID 31462090 DOI: 10.1161/Atvbaha.119.312952  0.625
2019 Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, ... ... Temel RE, et al. The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Nature Metabolism. 1: 98-110. PMID 31410392 DOI: 10.1038/s42255-018-0004-9  0.387
2019 AlSiraj Y, Chen X, Thatcher SE, Temel RE, Cai L, Blalock E, Katz W, Ali HM, Petriello M, Deng P, Morris AJ, Wang X, Lusis AJ, Arnold AP, Reue K, et al. XX sex chromosome complement promotes atherosclerosis in mice. Nature Communications. 10: 2631. PMID 31201301 DOI: 10.1038/S41467-019-10462-Z  0.394
2019 Kim S, Graham MJ, Lee RG, Yang L, Kim S, Subramanian V, Layne JD, Cai L, Temel RE, Shih D, Lusis AJ, Berliner JA, Lee S. Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis. Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd. PMID 30738642 DOI: 10.1016/J.Numecd.2018.12.006  0.308
2019 Coffey AR, Kanke M, Smallwood TL, Albright J, Pitman W, Gharaibeh RZ, Hua K, Gertz E, Biddinger SB, Temel RE, Pomp D, Sethupathy P, Bennett BJ. microRNA-146a association with the cardiometabolic disease risk factor TMAO. Physiological Genomics. PMID 30633643 DOI: 10.1152/Physiolgenomics.00079.2018  0.424
2018 Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, ... ... Temel RE, et al. Author Correction: Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates. Nature Biomedical Engineering. 2: 623. PMID 31015637 DOI: 10.1038/S41551-018-0281-3  0.308
2018 Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, ... ... Temel RE, et al. Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates. Nature Biomedical Engineering. 2: 279-292. PMID 30936448 DOI: 10.1038/S41551-018-0221-2  0.361
2018 Patel SB, Graf G, Temel R. ABCG5 and ABCG8: More than a defense against xenosterols. Journal of Lipid Research. PMID 29728459 DOI: 10.1194/Jlr.R084244  0.448
2018 Allen SD, Liu YG, Bobbala S, Cai L, Hecker PI, Temel R, Scott EA. Polymersomes scalably fabricated via flash nanoprecipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration Nano Research. 11: 5689-5703. DOI: 10.1007/S12274-018-2069-X  0.334
2017 Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, de Aguiar Vallim TQ, Sallam T, Tontonoz P. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. Elife. 6. PMID 29068315 DOI: 10.7554/Elife.28766  0.585
2017 Cheng HS, Besla R, Li A, Chen Z, Shikatani EA, Nazari-Jahantigh M, Hammoutène A, Nguyen MA, Geoffrion M, Cai L, Khyzha N, Li T, MacParland SA, Husain M, Cybulsky MI, ... ... Temel RE, et al. Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a. Circulation Research. PMID 28637783 DOI: 10.1161/Circresaha.116.310529  0.367
2017 Brown JM, Temel RE, Graf GA. Para-bile-osis Establishes a Role for Nonbiliary Macrophage to Feces Reverse Cholesterol Transport. Arteriosclerosis, Thrombosis, and Vascular Biology. 37: 738-739. PMID 28446467 DOI: 10.1161/Atvbaha.117.309224  0.476
2017 Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, Vallim TQdA, Sallam T, Tontonoz P. Author response: Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP Elife. DOI: 10.7554/Elife.28766.018  0.432
2016 Ouimet M, Hennessy EJ, van Solingen C, Koelwyn GJ, Hussein MA, Ramkhelawon B, Rayner KJ, Temel RE, Perisic L, Hedin U, Maegdefessel L, Garabedian MJ, Holdt LM, Teupser D, Moore KJ. miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26941018 DOI: 10.1161/Atvbaha.116.307282  0.557
2015 Temel RE, Brown JM. A new model of reverse cholesterol transport: enTICEing strategies to stimulate intestinal cholesterol excretion. Trends in Pharmacological Sciences. PMID 25930707 DOI: 10.1016/J.Tips.2015.04.002  0.53
2015 Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, ... ... Temel RE, et al. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Cell Reports. PMID 25600868 DOI: 10.1016/J.Celrep.2014.12.036  0.801
2015 Okla M, Ha JH, Temel RE, Chung S. BMP7 drives human adipogenic stem cells into metabolically active beige adipocytes. Lipids. 50: 111-20. PMID 25534037 DOI: 10.1007/S11745-014-3981-9  0.354
2015 Temel RE. Hepatic or intestinal ABCG5 and ABCG8 are sufficient to block the development of sitosterolemia Journal of Lipid Research. 56: 201-202. PMID 25527605 DOI: 10.1194/Jlr.C056945  0.594
2014 Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, ... Temel RE, et al. The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice. Cell Metabolism. 20: 910-8. PMID 25440061 DOI: 10.1016/J.Cmet.2014.10.001  0.796
2014 Zhang H, Temel RE, Martel C. Cholesterol and lipoprotein metabolism: Early Career Committee contribution. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1791-4. PMID 25142876 DOI: 10.1161/Atvbaha.114.304267  0.596
2014 Medina MW, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, Schubert C, Mangravite LM, Rudel LL, Temel RE, Runz H, Krauss RM. Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1917-23. PMID 25035345 DOI: 10.1161/Atvbaha.113.302806  0.508
2014 Chung S, Cuffe H, Marshall SM, McDaniel AL, Ha JH, Kavanagh K, Hong C, Tontonoz P, Temel RE, Parks JS. Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1880-7. PMID 24969772 DOI: 10.1161/Atvbaha.114.303896  0.772
2014 Marshall SM, Gromovsky AD, Kelley KL, Davis MA, Wilson MD, Lee RG, Crooke RM, Graham MJ, Rudel LL, Brown JM, Temel RE. Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion. Plos One. 9: e98953. PMID 24901470 DOI: 10.1371/Journal.Pone.0098953  0.589
2014 Marshall SM, Kelley KL, Davis MA, Wilson MD, McDaniel AL, Lee RG, Crooke RM, Graham MJ, Rudel LL, Brown JM, Temel RE. Reduction of VLDL secretion decreases cholesterol excretion in niemann-pick C1-like 1 hepatic transgenic mice. Plos One. 9: e84418. PMID 24404162 DOI: 10.1371/Journal.Pone.0084418  0.822
2013 Bura KS, Lord C, Marshall S, McDaniel A, Thomas G, Warrier M, Zhang J, Davis MA, Sawyer JK, Shah R, Wilson MD, Dikkers A, Tietge UJ, Collet X, Rudel LL, ... Temel RE, et al. Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice. Journal of Lipid Research. 54: 1567-77. PMID 23564696 DOI: 10.1194/Jlr.M034454  0.812
2013 McDaniel AL, Alger HM, Sawyer JK, Kelley KL, Kock ND, Brown JM, Temel RE, Rudel LL. Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice. The American Journal of Pathology. 182: 1131-8. PMID 23380580 DOI: 10.1016/J.Ajpath.2012.12.014  0.759
2013 Voruganti VS, Jorgensen MJ, Kaplan JR, Kavanagh K, Rudel LL, Temel R, Fairbanks LA, Comuzzie AG. Significant genotype by diet (G × D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus). American Journal of Primatology. 75: 491-9. PMID 23315630 DOI: 10.1002/Ajp.22125  0.393
2013 Saddar S, Carriere V, Lee WR, Tanigaki K, Yuhanna IS, Parathath S, Morel E, Warrier M, Sawyer JK, Gerard RD, Temel RE, Brown JM, Connelly M, Mineo C, Shaul PW. Scavenger receptor class B type I is a plasma membrane cholesterol sensor. Circulation Research. 112: 140-51. PMID 23023567 DOI: 10.1161/Circresaha.112.280081  0.445
2013 Beason DP, Hsu JE, Marshall SM, McDaniel AL, Temel RE, Abboud JA, Soslowsky LJ. Hypercholesterolemia increases supraspinatus tendon stiffness and elastic modulus across multiple species. Journal of Shoulder and Elbow Surgery / American Shoulder and Elbow Surgeons ... [Et Al.]. 22: 681-6. PMID 22981355 DOI: 10.1016/J.Jse.2012.07.008  0.768
2012 Temel RE, Brown JM. Biliary and nonbiliary contributions to reverse cholesterol transport. Current Opinion in Lipidology. 23: 85-90. PMID 22262055 DOI: 10.1097/Mol.0B013E3283508C21  0.503
2012 Owens AP, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, ... ... Temel RE, et al. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. The Journal of Clinical Investigation. 122: 558-68. PMID 22214850 DOI: 10.1172/Jci58969  0.784
2011 Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Goedeke L, Liu X, Khatsenko OG, Kaimal V, Lees CJ, Fernandez-Hernando C, Fisher EA, ... Temel RE, et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature. 478: 404-7. PMID 22012398 DOI: 10.1038/Nature10486  0.761
2011 Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, van Gils JM, Rayner AJ, Chang AN, Suarez Y, Fernandez-Hernando C, Fisher EA, Moore KJ. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. The Journal of Clinical Investigation. 121: 2921-31. PMID 21646721 DOI: 10.1172/Jci57275  0.503
2011 Medina MW, Gao F, Naidoo D, Rudel LL, Temel RE, McDaniel AL, Marshall SM, Krauss RM. Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. Plos One. 6: e19420. PMID 21559365 DOI: 10.1371/Journal.Pone.0019420  0.786
2010 Temel RE, Brown JM. A new framework for reverse cholesterol transport: non-biliary contributions to reverse cholesterol transport. World Journal of Gastroenterology : Wjg. 16: 5946-52. PMID 21157970 DOI: 10.3748/Wjg.V16.I47.5946  0.555
2010 Temel RE, Sawyer JK, Yu L, Lord C, Degirolamo C, McDaniel A, Marshall S, Wang N, Shah R, Rudel LL, Brown JM. Biliary sterol secretion is not required for macrophage reverse cholesterol transport. Cell Metabolism. 12: 96-102. PMID 20620999 DOI: 10.1016/J.Cmet.2010.05.011  0.798
2009 Temel RE, Brown JM, Ma Y, Tang W, Rudel LL, Ioannou YA, Davies JP, Yu L. Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent Journal of Lipid Research. 50: 915-923. PMID 19141868 DOI: 10.1194/Jlr.M800631-Jlr200  0.647
2007 Temel RE, Rudel LL. Diet effects on atherosclerosis in mice. Current Drug Targets. 8: 1150-60. PMID 18045093 DOI: 10.2174/138945007782403847  0.557
2007 Temel RE, Tang W, Ma Y, Rudel LL, Willingham MC, Ioannou YA, Davies JP, Nilsson LM, Yu L. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe Journal of Clinical Investigation. 117: 1968-1978. PMID 17571164 DOI: 10.1172/Jci30060  0.598
2007 Temel RE, Hou L, Rudel LL, Shelness GS. ACAT2 stimulates cholesteryl ester secretion in apoB-containing lipoproteins. Journal of Lipid Research. 48: 1618-27. PMID 17438337 DOI: 10.1194/Jlr.M700109-Jlr200  0.513
2005 Temel RE, Lee RG, Kelley KL, Davis MA, Shah R, Sawyer JK, Wilson MD, Rudel LL. Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2. Journal of Lipid Research. 46: 2423-31. PMID 16150828 DOI: 10.1194/Jlr.M500232-Jlr200  0.623
2003 Temel RE, Gebre AK, Parks JS, Rudel LL. Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol. The Journal of Biological Chemistry. 278: 47594-601. PMID 12975367 DOI: 10.1074/Jbc.M308235200  0.556
2003 Temel RE, Parks JS, Williams DL. Enhancement of scavenger receptor class B type I-mediated selective cholesteryl ester uptake from apoA-I(-/-) high density lipoprotein (HDL) by apolipoprotein A-I requires HDL reorganization by lecithin cholesterol acyltransferase. The Journal of Biological Chemistry. 278: 4792-9. PMID 12473673 DOI: 10.1074/Jbc.M208160200  0.544
2002 Temel RE, Walzem RL, Banka CL, Williams DL. Apolipoprotein A-I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI-mediated cholesteryl ester-selective uptake. The Journal of Biological Chemistry. 277: 26565-72. PMID 12000760 DOI: 10.1074/jbc.M203014200  0.432
1999 Williams DL, Connelly MA, Temel RE, Swarnakar S, Phillips MC, De la Llera-Moya M, Rothblat GH. Scavenger receptor BI and cholesterol trafficking Current Opinion in Lipidology. 10: 329-339. PMID 10482136 DOI: 10.1097/00041433-199908000-00007  0.488
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