Zhe-Sheng Chen - Publications

St. John's University (New York), School of Pharmacy 
Cell Biology, Molecular Biology, Pharmacology

151 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cui Q, Cai CY, Wang JQ, Zhang S, Gupta P, Ji N, Yang Y, Dong X, Yang DH, Chen ZS. Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells. International Journal of Molecular Sciences. 20. PMID 31443367 DOI: 10.3390/ijms20174095  0.52
2019 Cai CY, Zhai H, Lei ZN, Tan CP, Chen BL, Du ZY, Wang JQ, Zhang YK, Wang YJ, Gupta P, Wang B, Chen ZS. Benzoyl indoles with metabolic stability as reversal agents for ABCG2-mediated multidrug resistance. European Journal of Medicinal Chemistry. 179: 849-862. PMID 31302589 DOI: 10.1016/j.ejmech.2019.06.066  0.52
2019 Ji N, Yang Y, Cai CY, Wang JQ, Lei ZN, Wu ZX, Cui Q, Yang DH, Chen ZS, Kong D. Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an Study. Frontiers in Oncology. 9: 514. PMID 31275850 DOI: 10.3389/fonc.2019.00514  0.36
2019 Teng QX, Ashar YV, Gupta P, Gadee E, Fan YF, Reznik SE, Wurpel JND, Chen ZS. Revisiting mTOR inhibitors as anticancer agents. Drug Discovery Today. PMID 31173912 DOI: 10.1016/j.drudis.2019.05.030  0.52
2019 Cui Q, Cai CY, Gao HL, Ren L, Ji N, Gupta P, Yang Y, Shukla S, Ambudkar SV, Yang DH, Chen ZS. Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells. Frontiers in Oncology. 9: 313. PMID 31106148 DOI: 10.3389/fonc.2019.00313  0.52
2019 Wen Y, Zhao R, Gupta P, Fan Y, Zhang Y, Huang Z, Li X, Su Y, Liao L, Xie YA, Yang D, Chen ZS, Liang G. The epigallocatechin gallate derivative Y reverses drug resistance mediated by the ABCB1 transporter both and . Acta Pharmaceutica Sinica. B. 9: 316-323. PMID 30972279 DOI: 10.1016/j.apsb.2018.10.001  0.52
2019 Zeng L, Li J, Zhang C, Zhang YK, Zhang W, Huang J, Ashby CR, Chen ZS, Chao H. An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms. Chemical Communications (Cambridge, England). PMID 30869688 DOI: 10.1039/c9cc00882a  0.4
2019 Cui Q, Yang Y, Ji N, Wang JQ, Ren L, Yang DH, Chen ZS. Gaseous signaling molecules and their application in resistant cancer treatment: from invisible to visible. Future Medicinal Chemistry. PMID 30802141 DOI: 10.4155/fmc-2018-0403  0.36
2019 Narayanan S, Gupta P, Nazim U, Ali M, Karadkhelkar N, Ahmad M, Chen ZS. Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines. The International Journal of Biochemistry & Cell Biology. PMID 30794858 DOI: 10.1016/j.biocel.2019.02.004  0.52
2019 Gupta P, Gao HL, Ashar YV, Karadkhelkar NM, Yoganathan S, Chen ZS. Ciprofloxacin Enhances the Chemosensitivity of Cancer Cells to ABCB1 Substrates. International Journal of Molecular Sciences. 20. PMID 30641875 DOI: 10.3390/ijms20020268  0.52
2018 Zhao RQ, Wen Y, Gupta P, Lei ZN, Cai CY, Liang G, Yang DH, Chen ZS, Xie YA. Y, an Epigallocatechin Gallate Derivative, Reverses ABCG2-Mediated Mitoxantrone Resistance. Frontiers in Pharmacology. 9: 1545. PMID 30687102 DOI: 10.3389/fphar.2018.01545  0.52
2018 Li W, Xu F, Shuai W, Sun H, Yao H, Ma C, Xu S, Yao H, Zhu Z, Yang DH, Chen ZS, Xu J. Discovery of Novel Quinoline-Chalcone Derivatives as Potent Anti-tumor Agents with Microtubule Polymerization Inhibitory Activity. Journal of Medicinal Chemistry. PMID 30525584 DOI: 10.1021/acs.jmedchem.8b01755  0.36
2018 Cui Q, Wang JQ, Assaraf YG, Ren L, Gupta P, Wei L, Ashby CR, Yang DH, Chen ZS. Modulating ROS to overcome multidrug resistance in cancer. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 41: 1-25. PMID 30471641 DOI: 10.1016/j.drup.2018.11.001  0.52
2018 Ji N, Yang Y, Lei ZN, Cai CY, Wang JQ, Gupta P, Xian X, Yang DH, Kong D, Chen ZS. Ulixertinib (BVD-523) antagonizes ABCB1- and ABCG2-mediated chemotherapeutic drug resistance. Biochemical Pharmacology. 158: 274-285. PMID 30431011 DOI: 10.1016/j.bcp.2018.10.028  0.52
2018 Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Teng QX, Chen ZS, Kong D, Yang DH. VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters. Frontiers in Pharmacology. 9: 1236. PMID 30425643 DOI: 10.3389/fphar.2018.01236  0.52
2018 Zhang YK, Wang YJ, Lei ZN, Zhang GN, Zhang XY, Wang DS, Al Rihani SB, Shukla S, Ambudkar SV, Kaddoumi A, Shi Z, Chen ZS. Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer. Cancer Letters. PMID 30392788 DOI: 10.1016/j.canlet.2018.10.032  0.4
2018 De Vera AA, Gupta P, Lei Z, Liao D, Narayanan S, Teng Q, Reznik SE, Chen ZS. Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo. Cancer Letters. PMID 30391357 DOI: 10.1016/j.canlet.2018.10.020  0.52
2018 Zhang W, Fan YF, Cai CY, Wang JQ, Teng QX, Lei ZN, Zeng L, Gupta P, Chen ZS. Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells. Frontiers in Pharmacology. 9: 1097. PMID 30356705 DOI: 10.3389/fphar.2018.01097  0.52
2018 Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Shukla S, Ambudkar SV, Kong D, Chen ZS. Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. Cancer Letters. PMID 30315846 DOI: 10.1016/j.canlet.2018.10.007  0.52
2018 Lamson TL, Khan S, Wang Z, Zhang YK, Yu Y, Chen ZS, Xu H. Patterned Synthesis of ZnO Nanorod Arrays for Nanoplasmonic Waveguide Applications. Optics Communications. 411: 53-58. PMID 30140109 DOI: 10.1016/j.optcom.2017.10.070  0.4
2018 Wang B, Ma LY, Wang JQ, Lei ZN, Gupta P, Zhao YD, Li ZH, Liu Y, Zhang XH, Li YN, Zhao B, Chen ZS, Liu HM. Discovery of 5-cyano-6-phenylpyrimidin derivatives containing an acylurea moiety as orally bioavailable reversal agents against P-glycoprotein-mediated mutidrug resistance. Journal of Medicinal Chemistry. PMID 29975529 DOI: 10.1021/acs.jmedchem.8b00335  0.52
2018 Cui Q, Yang DH, Chen ZS. Special Issue: Natural Products: Anticancer and Beyond. Molecules (Basel, Switzerland). 23. PMID 29882875 DOI: 10.3390/molecules23061246  0.36
2018 Zhang GN, Zhang YK, Wang YJ, Gupta P, Ashby CR, Alqahtani S, Deng T, Bates SE, Kaddoumi A, Wurpel JND, Lei YX, Chen ZS. Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo. Cancer Letters. PMID 29518481 DOI: 10.1016/j.canlet.2018.02.040  0.52
2018 Gupta P, Zhang YK, Zhang XY, Wang YJ, Lu KW, Hall T, Peng R, Yang DH, Xie N, Chen ZS. Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 45: 1515-1528. PMID 29486476 DOI: 10.1159/000487578  0.52
2018 Fan YF, Zhang W, Zeng L, Lei ZN, Cai CY, Gupta P, Yang DH, Cui Q, Qin ZD, Chen ZS, Trombetta LD. Dacomitinib antagonizes multidrug resistance (MDR) in cancer cells by inhibiting the efflux activity of ABCB1 and ABCG2 transporters. Cancer Letters. PMID 29331420 DOI: 10.1016/j.canlet.2018.01.021  0.52
2017 Patel BA, Abel B, Barbuti AM, Velagapudi UK, Chen ZS, Ambudkar SV, Talele TT. Comprehensive Synthesis of Amino Acid-derived Thiazole Peptidomimetic Analogues to Understand Enigmatic Drug/Substrate-Binding Site of P-glycoprotein. Journal of Medicinal Chemistry. PMID 29251928 DOI: 10.1021/acs.jmedchem.7b01340  0.4
2017 Li J, Kumar P, Anreddy N, Zhang YK, Wang YJ, Chen Y, Talele TT, Gupta K, Trombetta LD, Chen ZS. Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies. Oncotarget. 8: 93785-93799. PMID 29212189 DOI: 10.18632/oncotarget.21078  0.72
2017 Zhang YK, Dai C, Yuan CG, Wu HC, Xiao Z, Lei ZN, Yang DH, Le XC, Fu L, Chen ZS. Establishment and characterization of arsenic trioxide resistant KB/ATO cells. Acta Pharmaceutica Sinica. B. 7: 564-570. PMID 28924550 DOI: 10.1016/j.apsb.2017.04.001  0.4
2017 Gujarati NA, Zeng L, Gupta P, Chen ZS, Korlipara VL. Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28916341 DOI: 10.1016/j.bmcl.2017.09.009  0.52
2017 Zeng L, Gupta P, Chen Y, Wang E, Ji L, Chao H, Chen ZS. The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials. Chemical Society Reviews. PMID 28654103 DOI: 10.1039/c7cs00195a  0.52
2017 Patel A, Li TW, Anreddy N, Wang DS, Sodani K, Gadhia S, Kathawala R, Yang DH, Cheng C, Chen ZS. Suppression of ABCG2 mediated MDR in vitro and in vivo by a novel inhibitor of ABCG2 drug transport. Pharmacological Research. PMID 28455266 DOI: 10.1016/j.phrs.2017.04.025  0.72
2017 Wen Y, Zhao RQ, Zhang YK, Gupta P, Fu LX, Tang AZ, Liu BM, Chen ZS, Yang DH, Liang G. Effect of Y6, an epigallocatechingallate derivative, on reversing doxorubicin drug resistance in human hepatocellular carcinoma cells. Oncotarget. PMID 28423656 DOI: 10.18632/oncotarget.15964  0.52
2017 Wang YJ, Zhang YK, Zhang GN, Al Rihani SB, Wei MN, Gupta P, Zhang XY, Shukla S, Ambudkar SV, Kaddoumi A, Shi Z, Chen ZS. Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study. Cancer Letters. PMID 28302530 DOI: 10.1016/j.canlet.2017.03.011  0.52
2017 Gupta P, Xie M, Narayanan S, Wang YJ, Wang XQ, Yuan T, Wang Z, Yang DH, Chen ZS. GSK1904529A, a Potent IGF-IR Inhibitor, Reverses MRP1-mediated Multidrug Resistance. Journal of Cellular Biochemistry. PMID 28266043 DOI: 10.1002/jcb.25975  0.52
2017 Zhang H, Patel AS, Wang YJ, Zhang YK, Kathawala RJ, Qiu LH, Patel BA, Huang LH, Shukla S, Yang DH, Ambudkar SV, Fu L, Chen ZS. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Molecular Cancer Therapeutics. PMID 28265007 DOI: 10.1158/1535-7163.MCT-16-0511  0.72
2017 Zhang YK, Zhang XY, Zhang GN, Wang YJ, Xu H, Zhang D, Shukla S, Liu L, Yang DH, Ambudkar SV, Chen ZS. Selective Reversal of BCRP-mediated MDR by VEGFR-2 inhibitor ZM323881. Biochemical Pharmacology. PMID 28242251 DOI: 10.1016/j.bcp.2017.02.019  0.4
2017 Wang YJ, Patel BA, Anreddy N, Zhang YK, Zhang GN, Alqahtani S, Singh S, Shukla S, Kaddoumi A, Ambudkar SV, Talele TT, Chen ZS. Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1. Scientific Reports. 7: 42106. PMID 28181548 DOI: 10.1038/srep42106  0.72
2017 Xu S, Yao H, Luo S, Zhang YK, Yang DH, Li D, Wang G, Hu M, Qiu Y, Wu X, Yao H, Xie W, Chen ZS, Xu J. A novel potent anticancer compound optimized from a natural oridonin scaffold induces apoptosis and cell cycle arrest through the mitochondrial pathway. Journal of Medicinal Chemistry. PMID 28165738 DOI: 10.1021/acs.jmedchem.6b01652  0.4
2017 Zhang GN, Zhang YK, Wang YJ, Barbuti AM, Zhu XJ, Yu XY, Wen AW, Wurpel JN, Chen ZS. Modulating the function of ATP-binding cassette subfamily G member 2 (ABCG2) inhibitor cabozantinib. Pharmacological Research. PMID 28131876 DOI: 10.1016/j.phrs.2017.01.024  0.72
2017 Kathawala RJ, Li T, Yang D, Guo HQ, Yang DH, Chen X, Cheng C, Chen ZS. 2-Trifluoromethyl-2-Hydroxypropionamide Derivatives as Novel Reversal Agents of ABCG2 (BCRP)-Mediated Multidrug Resistance: Synthesis and Biological Evaluations. Journal of Cellular Biochemistry. PMID 28120346 DOI: 10.1002/jcb.25908  0.72
2016 Whitt JD, Keeton AB, Gary BD, Sklar LA, Sodani K, Chen ZS, Piazza GA. Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion. Journal of Biomedical Research. 30: 120-133. PMID 28276667 DOI: 10.7555/JBR.30.20150108  0.72
2016 Zhang WJ, Li Y, Wei MN, Chen Y, Qiu JG, Jiang QW, Yang Y, Zheng DW, Qin WM, Huang JR, Wang K, Zhang WJ, Wang YJ, Yang DH, Chen ZS, et al. Synergistic antitumor activity of regorafenib and lapatinib in preclinical models of human colorectal cancer. Cancer Letters. PMID 27864115 DOI: 10.1016/j.canlet.2016.11.011  0.4
2016 Gupta P, Kathawala RJ, Wei L, Wang F, Wang X, Druker BJ, Fu LW, Chen ZS. PBA2, a novel inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia. Cancer Letters. PMID 27720778 DOI: 10.1016/j.canlet.2016.09.025  0.72
2016 Zhang XY, Zhang YK, Wang YJ, Gupta P, Zeng L, Xu M, Wang XQ, Yang DH, Chen ZS. Osimertinib (AZD9291), a Mutant-Selective EGFR Inhibitor, Reverses ABCB1-Mediated Drug Resistance in Cancer Cells. Molecules (Basel, Switzerland). 21. PMID 27649127 DOI: 10.3390/molecules21091236  0.32
2016 Li W, Zhang H, Assaraf YG, Zhao K, Xu X, Xie J, Yang DH, Chen ZS. Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 27: 14-29. PMID 27449595 DOI: 10.1016/j.drup.2016.05.001  0.36
2016 Zhang YK, Zhang GN, Wang YJ, Patel BA, Talele TT, Yang DH, Chen ZS. Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters. Scientific Reports. 6: 25694. PMID 27157787 DOI: 10.1038/srep25694  0.4
2016 Jones VS, Huang RY, Chen LP, Chen ZS, Fu L, Huang RP. Cytokines in cancer drug resistance: Cues to new therapeutic strategies. Biochimica Et Biophysica Acta. PMID 26993403 DOI: 10.1016/j.bbcan.2016.03.005  0.32
2016 Gupta P, Jani KA, Yang DH, Sadoqi M, Squillante E, Chen ZS. Revisiting the role of nanoparticles as modulators of drug resistance and metabolism in cancer. Expert Opinion On Drug Metabolism & Toxicology. PMID 26799671 DOI: 10.1517/17425255.2016.1145655  0.32
2015 Wang YJ, Huang Y, Anreddy N, Zhang GN, Zhang YK, Xie M, Lin D, Yang DH, Zhang M, Chen ZS. Tea nanoparticle, a safe and biocompatible nanocarrier, greatly potentiates the anticancer activity of doxorubicin. Oncotarget. PMID 26716507 DOI: 10.18632/oncotarget.6711  0.32
2015 Anreddy N, Patel A, Zhang YK, Wang YJ, Shukla S, Kathawala RJ, Kumar P, Gupta P, Ambudkar SV, Wurpel JN, Chen ZS, Guo H. A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo. Oncotarget. PMID 26515463 DOI: 10.18632/oncotarget.5747  0.72
2015 Yao N, Li YJ, Zhang DM, Liu DL, Tang MK, Yiu A, Li Y, Chen WM, Lan P, Yao Z, Chen ZS, Ye WC. B4G2 Induces Mitochondrial Apoptosis by the ROS-Mediated Opening of Ca2+-Dependent Permeability Transition Pores. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 37: 838-852. PMID 26382946 DOI: 10.1159/000430212  0.32
2015 Zhang GN, Ashby CR, Zhang YK, Chen ZS, Guo H. The reversal of antineoplastic drug resistance in cancer cells by β-elemene. Chinese Journal of Cancer. 34: 45. PMID 26370907 DOI: 10.1186/s40880-015-0048-0  0.4
2015 Singha B, Gatla HR, Phyo S, Patel A, Chen ZS, Vancurova I. IKK inhibition increases bortezomib effectiveness in ovarian cancer. Oncotarget. 6: 26347-58. PMID 26267322 DOI: 10.18632/oncotarget.4713  0.72
2015 Huang Y, Wang YJ, Wang Y, Yi S, Fan Z, Sun L, Lin D, Anreddy N, Zhu H, Schmidt M, Chen ZS, Zhang M. Exploring naturally occurring ivy nanoparticles as an alternative biomaterial. Acta Biomaterialia. PMID 26219859 DOI: 10.1016/j.actbio.2015.07.035  0.32
2015 Kathawala RJ, Wang YJ, Shukla S, Zhang YK, Alqahtani S, Kaddoumi A, Ambudkar SV, Ashby CR, Chen ZS. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel. Chinese Journal of Cancer. 34: 115-20. PMID 25962593 DOI: 10.1186/s40880-015-0003-0  0.72
2015 Zhang Y, Zhang YK, Wang YJ, Vispute SG, Jain S, Chen Y, Li J, Youssef DT, Sayed KA, Chen ZS. Esters of the marine-derived triterpene sipholenol A reverse P-GP-mediated drug resistance. Marine Drugs. 13: 2267-86. PMID 25874923 DOI: 10.3390/md13042267  0.4
2015 Zhang YK, Wang YJ, Gupta P, Chen ZS. Multidrug Resistance Proteins (MRPs) and Cancer Therapy. The Aaps Journal. 17: 802-12. PMID 25840885 DOI: 10.1208/s12248-015-9757-1  0.52
2015 Liu DL, Li YJ, Yang DH, Wang CR, Xu J, Yao N, Zhang XQ, Chen ZS, Ye WC, Zhang DM. Ganoderma lucidum derived ganoderenic acid B reverses ABCB1-mediated multidrug resistance in HepG2/ADM cells. International Journal of Oncology. 46: 2029-38. PMID 25779097 DOI: 10.3892/ijo.2015.2925  0.32
2015 Kathawala RJ, Gupta P, Ashby CR, Chen ZS. The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 18: 1-17. PMID 25554624 DOI: 10.1016/j.drup.2014.11.002  0.72
2015 Hasinoff BB, Wu X, Yadav AA, Patel D, Zhang H, Wang DS, Chen ZS, Yalowich JC. Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II). Biochemical Pharmacology. 93: 266-76. PMID 25550273 DOI: 10.1016/j.bcp.2014.12.008  0.4
2015 Wei L, Lu J, Xu H, Patel A, Chen ZS, Chen G. Silver nanoparticles: synthesis, properties, and therapeutic applications. Drug Discovery Today. 20: 595-601. PMID 25543008 DOI: 10.1016/j.drudis.2014.11.014  0.32
2015 Kathawala RJ, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, Zhang YK, Wang YJ, Sodani K, Kaddoumi A, Ashby CR, Chen ZS. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 6: 510-21. PMID 25402202 DOI: 10.18632/oncotarget.2638  0.72
2014 Anreddy N, Patel A, Sodani K, Kathawala RJ, Chen EP, Wurpel JN, Chen ZS. PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR. Acta Pharmaceutica Sinica. B. 4: 202-207. PMID 26579384 DOI: 10.1016/j.apsb.2014.02.003  0.72
2014 Wang J, Wang YJ, Chen ZS, Kwon CH. Synthesis and evaluation of sulfonylethyl-containing phosphotriesters of 3'-azido-3'-deoxythymidine as anticancer prodrugs. Bioorganic & Medicinal Chemistry. 22: 5747-56. PMID 25440502 DOI: 10.1016/j.bmc.2014.09.046  0.32
2014 Wang YJ, Zhang YK, Kathawala RJ, Chen ZS. Repositioning of Tyrosine Kinase Inhibitors as Antagonists of ATP-Binding Cassette Transporters in Anticancer Drug Resistance. Cancers. 6: 1925-52. PMID 25268163 DOI: 10.3390/cancers6041925  0.72
2014 Minami K, Kamijo Y, Nishizawa Y, Tabata S, Horikuchi F, Yamamoto M, Kawahara K, Shinsato Y, Tachiwada T, Chen ZS, Tsujikawa K, Nakagawa M, Seki N, Akiyama S, Arima K, et al. Expression of ABCB6 is related to resistance to 5-FU, SN-38 and vincristine. Anticancer Research. 34: 4767-73. PMID 25202056  0.32
2014 Anreddy N, Gupta P, Kathawala RJ, Patel A, Wurpel JN, Chen ZS. Tyrosine kinase inhibitors as reversal agents for ABC transporter mediated drug resistance. Molecules (Basel, Switzerland). 19: 13848-77. PMID 25191874 DOI: 10.3390/molecules190913848  0.72
2014 Wang DS, Rizwani GH, Guo H, Ahmed M, Ahmed M, Hassan SZ, Hassan A, Chen ZS, Xu RH. Annona squamosa Linn: cytotoxic activity found in leaf extract against human tumor cell lines. Pakistan Journal of Pharmaceutical Sciences. 27: 1559-63. PMID 25176251  0.4
2014 Zhang H, Patel A, Ma SL, Li XJ, Zhang YK, Yang PQ, Kathawala RJ, Wang YJ, Anreddy N, Fu LW, Chen ZS. In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1. British Journal of Pharmacology. 171: 5845-57. PMID 25164592 DOI: 10.1111/bph.12889  0.32
2014 Tang SJ, Chen LK, Wang F, Zhang YK, Huang ZC, To KK, Wang XK, Talele TT, Chen ZS, Chen WQ, Fu LW. CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function. Biochemical Pharmacology. 91: 144-56. PMID 25058526 DOI: 10.1016/j.bcp.2014.07.008  0.4
2014 Xu S, Pei L, Wang C, Zhang YK, Li D, Yao H, Wu X, Chen ZS, Sun Y, Xu J. Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. Acs Medicinal Chemistry Letters. 5: 797-802. PMID 25050168 DOI: 10.1021/ml500141f  0.4
2014 Wang DS, Patel A, Shukla S, Zhang YK, Wang YJ, Kathawala RJ, Robey RW, Zhang L, Yang DH, Talele TT, Bates SE, Ambudkar SV, Xu RH, Chen ZS. Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2. Oncotarget. 5: 4529-42. PMID 24980828 DOI: 10.18632/oncotarget.2102  0.72
2014 Huang XC, Xiao X, Zhang YK, Talele TT, Salim AA, Chen ZS, Capon RJ. Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells. Marine Drugs. 12: 3818-37. PMID 24979269 DOI: 10.3390/md12073818  0.4
2014 Wang DS, Patel A, Sim HM, Zhang YK, Wang YJ, Kathawala RJ, Zhang H, Talele TT, Ambudkar SV, Xu RH, Chen ZS. ARRY-334543 reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2. Journal of Cellular Biochemistry. 115: 1381-91. PMID 24939447 DOI: 10.1002/jcb.24787  0.72
2014 Wang YJ, Kathawala RJ, Zhang YK, Patel A, Kumar P, Shukla S, Fung KL, Ambudkar SV, Talele TT, Chen ZS. Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1. Biochemical Pharmacology. 90: 367-78. PMID 24937702 DOI: 10.1016/j.bcp.2014.06.006  0.72
2014 Zhang H, Zhang YK, Wang YJ, Kathawala RJ, Patel A, Zhu H, Sodani K, Talele TT, Ambudkar SV, Chen ZS, Fu LW. WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells. Cancer Science. 105: 1071-8. PMID 24903205 DOI: 10.1111/cas.12462  0.72
2014 Singh S, Prasad NR, Chufan EE, Patel BA, Wang YJ, Chen ZS, Ambudkar SV, Talele TT. Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid. Journal of Medicinal Chemistry. 57: 4058-72. PMID 24773054 DOI: 10.1021/jm401966m  0.32
2014 Zhang H, Wang YJ, Zhang YK, Wang DS, Kathawala RJ, Patel A, Talele TT, Chen ZS, Fu LW. AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Cancer Letters. 350: 61-8. PMID 24747122 DOI: 10.1016/j.canlet.2014.04.008  0.72
2014 Zhang H, Kathawala RJ, Wang YJ, Zhang YK, Patel A, Shukla S, Robey RW, Talele TT, Ashby CR, Ambudkar SV, Bates SE, Fu LW, Chen ZS. Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance. The International Journal of Biochemistry & Cell Biology. 51: 111-9. PMID 24726739 DOI: 10.1016/j.biocel.2014.03.026  0.72
2014 Liu DL, Li YJ, Yao N, Xu J, Chen ZS, Yiu A, Zhang CX, Ye WC, Zhang DM. Acerinol, a cyclolanstane triterpenoid from Cimicifuga acerina, reverses ABCB1-mediated multidrug resistance in HepG2/ADM and MCF-7/ADR cells. European Journal of Pharmacology. 733: 34-44. PMID 24704556 DOI: 10.1016/j.ejphar.2014.03.043  0.32
2014 Kathawala RJ, Chen JJ, Zhang YK, Wang YJ, Patel A, Wang DS, Talele TT, Ashby CR, Chen ZS. Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. International Journal of Oncology. 44: 1634-42. PMID 24626598 DOI: 10.3892/ijo.2014.2341  0.72
2014 Sodani K, Patel A, Anreddy N, Singh S, Yang DH, Kathawala RJ, Kumar P, Talele TT, Chen ZS. Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Biochemical Pharmacology. 89: 52-61. PMID 24565910 DOI: 10.1016/j.bcp.2014.02.012  0.72
2014 Sun YL, Kumar P, Sodani K, Patel A, Pan Y, Baer MR, Chen ZS, Jiang WQ. Ponatinib enhances anticancer drug sensitivity in MRP7-overexpressing cells. Oncology Reports. 31: 1605-12. PMID 24481648 DOI: 10.3892/or.2014.3002  0.4
2014 Kathawala RJ, Sodani K, Chen K, Patel A, Abuznait AH, Anreddy N, Sun YL, Kaddoumi A, Ashby CR, Chen ZS. Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study. Molecular Cancer Therapeutics. 13: 714-23. PMID 24431074 DOI: 10.1158/1535-7163.MCT-13-0743  0.72
2014 Yang D, Kathawala RJ, Chufan EE, Patel A, Ambudkar SV, Chen ZS, Chen X. Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP). Future Oncology (London, England). 10: 1827-41. PMID 24295377 DOI: 10.2217/fon.13.253  0.72
2014 Guo HQ, Zhang GN, Wang YJ, Zhang YK, Sodani K, Talele TT, Ashby CR, Chen ZS. β-Elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter. Oncology Reports. 31: 858-66. PMID 24284783 DOI: 10.3892/or.2013.2870  0.72
2014 Kathawala RJ, Wang YJ, Ashby CR, Chen ZS. Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs. Chinese Journal of Cancer. 33: 223-30. PMID 24103790 DOI: 10.5732/cjc.013.10122  0.72
2013 Guo H, Wang DS, Rizwani GH, Ahmed M, Ahmed M, Hassan A, Xu RH, Mansoor N, Tiwari AK, Chen ZS. Antineoplastic activity of Holoptelea integrifolia (Roxb.) Planch bark extracts (in vitro). Pakistan Journal of Pharmaceutical Sciences. 26: 1151-6. PMID 24191320  0.4
2013 Chen JJ, Patel A, Sodani K, Xiao ZJ, Tiwari AK, Zhang DM, Li YJ, Yang DH, Ye WC, Chen SD, Chen ZS. bba, a synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10). Plos One. 8: e74573. PMID 24069321 DOI: 10.1371/journal.pone.0074573  0.72
2013 Chen J, Brown DP, Wang YJ, Chen ZS. New phenstatin-fatty acid conjugates: synthesis and evaluation. Bioorganic & Medicinal Chemistry Letters. 23: 5119-22. PMID 23932339 DOI: 10.1016/j.bmcl.2013.07.025  0.32
2013 Tiwari AK, Chen ZS. Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants. Frontiers in Pharmacology. 4: 82. PMID 23805103 DOI: 10.3389/fphar.2013.00082  0.4
2013 Patel A, Tiwari AK, Chufan EE, Sodani K, Anreddy N, Singh S, Ambudkar SV, Stephani R, Chen ZS. PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. Cancer Chemotherapy and Pharmacology. 72: 189-99. PMID 23673445 DOI: 10.1007/s00280-013-2184-z  0.32
2013 Zhao XQ, Dai CL, Ohnuma S, Liang YJ, Deng W, Chen JJ, Zeng MS, Ambudkar SV, Chen ZS, Fu LW. Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 49: 441-50. PMID 23619284 DOI: 10.1016/j.ejps.2013.04.015  0.32
2013 Deng W, Dai CL, Chen JJ, Kathawala RJ, Sun YL, Chen HF, Fu LW, Chen ZS. Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10). Oncology Reports. 29: 2479-85. PMID 23525656 DOI: 10.3892/or.2013.2362  0.72
2013 Zhang DM, Li YJ, Shu C, Ruan ZX, Chen WM, Yiu A, Peng YH, Wang J, Lan P, Yao Z, Fung KP, Fu LW, Chen ZS, Ye WC. Bipiperidinyl derivatives of 23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cells. Anti-Cancer Drugs. 24: 441-54. PMID 23466650 DOI: 10.1097/CAD.0b013e32835fcc77  0.32
2013 Huang XC, Sun YL, Salim AA, Chen ZS, Capon RJ. Parguerenes: Marine red alga bromoditerpenes as inhibitors of P-glycoprotein (ABCB1) in multidrug resistant human cancer cells. Biochemical Pharmacology. 85: 1257-68. PMID 23415901 DOI: 10.1016/j.bcp.2013.02.005  0.4
2013 Sun YL, Chen JJ, Kumar P, Chen K, Sodani K, Patel A, Chen YL, Chen SD, Jiang WQ, Chen ZS. Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar. Plos One. 8: e55576. PMID 23393594 DOI: 10.1371/journal.pone.0055576  0.72
2013 He D, Zhao XQ, Chen XG, Fang Y, Singh S, Talele TT, Qiu HJ, Liang YJ, Wang XK, Zhang GQ, Chen ZS, Fu LW. BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells. Plos One. 8: e54181. PMID 23349819 DOI: 10.1371/journal.pone.0054181  0.4
2013 Tiwari AK, Sodani K, Dai CL, Abuznait AH, Singh S, Xiao ZJ, Patel A, Talele TT, Fu L, Kaddoumi A, Gallo JM, Chen ZS. Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models. Cancer Letters. 328: 307-17. PMID 23063650 DOI: 10.1016/j.canlet.2012.10.001  0.72
2013 Liu KJ, He JH, Su XD, Sim HM, Xie JD, Chen XG, Wang F, Liang YJ, Singh S, Sodani K, Talele TT, Ambudkar SV, Chen ZS, Wu HY, Fu LW. Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo. International Journal of Cancer. Journal International Du Cancer. 132: 224-35. PMID 22623106 DOI: 10.1002/ijc.27649  0.72
2012 Kumar P, Zhang DM, Degenhardt K, Chen ZS. Autophagy and transporter-based multi-drug resistance. Cells. 1: 558-75. PMID 24710490 DOI: 10.3390/cells1030558  0.4
2012 Abraham I, El Sayed K, Chen ZS, Guo H. Current status on marine products with reversal effect on cancer multidrug resistance. Marine Drugs. 10: 2312-21. PMID 23170086 DOI: 10.3390/md10102312  0.36
2012 Li T, Yang Y, Cheng C, Tiwari AK, Sodani K, Zhao Y, Abraham I, Chen ZS. Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 22: 7268-71. PMID 23067553 DOI: 10.1016/j.bmcl.2012.07.057  0.72
2012 Zhang DM, Shu C, Chen JJ, Sodani K, Wang J, Bhatnagar J, Lan P, Ruan ZX, Xiao ZJ, Ambudkar SV, Chen WM, Chen ZS, Ye WC. BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo. Molecular Pharmaceutics. 9: 3147-59. PMID 23046348 DOI: 10.1021/mp300249s  0.72
2012 Shi Z, Yang WM, Chen LP, Yang DH, Zhou Q, Zhu J, Chen JJ, Huang RC, Chen ZS, Huang RP. Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production. Breast Cancer Research and Treatment. 135: 737-47. PMID 22923236 DOI: 10.1007/s10549-012-2196-0  0.4
2012 Sen R, Natarajan K, Bhullar J, Shukla S, Fang HB, Cai L, Chen ZS, Ambudkar SV, Baer MR. The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2. Molecular Cancer Therapeutics. 11: 2033-44. PMID 22778153 DOI: 10.1158/1535-7163.MCT-12-0302  0.32
2012 Kuang YH, Patel JP, Sodani K, Wu CP, Liao LQ, Patel A, Tiwari AK, Dai CL, Chen X, Fu LW, Ambudkar SV, Korlipara VL, Chen ZS. OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance. Biochemical Pharmacology. 84: 766-74. PMID 22750060 DOI: 10.1016/j.bcp.2012.06.019  0.32
2012 Cheng C, Liu ZG, Zhang H, Xie JD, Chen XG, Zhao XQ, Wang F, Liang YJ, Chen LK, Singh S, Chen JJ, Talele TT, Chen ZS, Zhong FT, Fu LW. Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202. Molecular Pharmaceutics. 9: 1971-82. PMID 22632055 DOI: 10.1021/mp2006714  0.4
2012 Sun YL, Kathawala RJ, Singh S, Zheng K, Talele TT, Jiang WQ, Chen ZS. Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Anti-Cancer Drugs. 23: 865-73. PMID 22614107 DOI: 10.1097/CAD.0b013e328354a196  0.72
2012 Chen JJ, Sun YL, Tiwari AK, Xiao ZJ, Sodani K, Yang DH, Vispute SG, Jiang WQ, Chen SD, Chen ZS. PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter. Cancer Science. 103: 1531-7. PMID 22578167 DOI: 10.1111/j.1349-7006.2012.02328.x  0.72
2012 Zhao XQ, Xie JD, Chen XG, Sim HM, Zhang X, Liang YJ, Singh S, Talele TT, Sun Y, Ambudkar SV, Chen ZS, Fu LW. Neratinib reverses ATP-binding cassette B1-mediated chemotherapeutic drug resistance in vitro, in vivo, and ex vivo. Molecular Pharmacology. 82: 47-58. PMID 22491935 DOI: 10.1124/mol.111.076299  0.4
2012 Sodani K, Tiwari AK, Singh S, Patel A, Xiao ZJ, Chen JJ, Sun YL, Talele TT, Chen ZS. GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance. Biochemical Pharmacology. 83: 1613-22. PMID 22414725 DOI: 10.1016/j.bcp.2012.02.028  0.72
2012 Shukla S, Chen ZS, Ambudkar SV. Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 70-80. PMID 22325423 DOI: 10.1016/j.drup.2012.01.005  0.32
2012 Sun YL, Patel A, Kumar P, Chen ZS. Role of ABC transporters in cancer chemotherapy. Chinese Journal of Cancer. 31: 51-7. PMID 22257384 DOI: 10.5732/cjc.011.10466  0.72
2012 Sodani K, Patel A, Kathawala RJ, Chen ZS. Multidrug resistance associated proteins in multidrug resistance. Chinese Journal of Cancer. 31: 58-72. PMID 22098952 DOI: 10.5732/cjc.011.10329  0.72
2012 Peng XX, Tiwari AK, Wu HC, Chen ZS. Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells. Chinese Journal of Cancer. 31: 110-8. PMID 22098951 DOI: 10.5732/cjc.011.10327  0.4
2011 Peng XX, Shi Z, Tiwari AK, Damaraju VL, Fu L, Cass CE, Ashby CR, Kruh GD, Chen ZS. Up-regulation of P-glycoprotein confers acquired resistance to 6-mercaptopurine in human chronic myeloid leukemia cells. Oncology Letters. 2: 549-556. PMID 22866119 DOI: 10.3892/ol.2011.288  0.4
2011 Patel JP, Kuang YH, Chen ZS, Korlipara VL. Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930 Bioorganic and Medicinal Chemistry Letters. 21: 6495-6499. PMID 21920748 DOI: 10.1016/j.bmcl.2011.08.070  0.32
2011 Yan YY, Zheng LS, Zhang X, Chen LK, Singh S, Wang F, Zhang JY, Liang YJ, Dai CL, Gu LQ, Zeng MS, Talele TT, Chen ZS, Fu LW. Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu. Molecular Pharmaceutics. 8: 1687-97. PMID 21812426 DOI: 10.1021/mp2000499  0.4
2011 Chen ZS, Tiwari AK. Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases. The Febs Journal. 278: 3226-45. PMID 21740521 DOI: 10.1111/j.1742-4658.2011.08235.x  0.4
2011 Shi Z, Tiwari AK, Patel AS, Fu LW, Chen ZS. Roles of sildenafil in enhancing drug sensitivity in cancer. Cancer Research. 71: 3735-8. PMID 21610107 DOI: 10.1158/0008-5472.CAN-11-0375  0.4
2011 Hopper-Borge EA, Churchill T, Paulose C, Nicolas E, Jacobs JD, Ngo O, Kuang Y, Grinberg A, Westphal H, Chen ZS, Klein-Szanto AJ, Belinsky MG, Kruh GD. Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice. Cancer Research. 71: 3649-57. PMID 21576088 DOI: 10.1158/0008-5472.CAN-10-3623  0.32
2011 Ding PR, Tiwari AK, Ohnuma S, Lee JW, An X, Dai CL, Lu QS, Singh S, Yang DH, Talele TT, Ambudkar SV, Chen ZS. The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter. Plos One. 6: e19329. PMID 21552528 DOI: 10.1371/journal.pone.0019329  0.32
2011 Shi Z, Tiwari AK, Shukla S, Robey RW, Singh S, Kim IW, Bates SE, Peng X, Abraham I, Ambudkar SV, Talele TT, Fu LW, Chen ZS. Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance. Cancer Research. 71: 3029-41. PMID 21402712 DOI: 10.1158/0008-5472.CAN-10-3820  0.4
2011 Tiwari AK, Sodani K, Dai CL, Ashby CR, Chen ZS. Revisiting the ABCs of multidrug resistance in cancer chemotherapy. Current Pharmaceutical Biotechnology. 12: 570-94. PMID 21118094  0.72
2010 Mi YJ, Liang YJ, Huang HB, Zhao HY, Wu CP, Wang F, Tao LY, Zhang CZ, Dai CL, Tiwari AK, Ma XX, To KK, Ambudkar SV, Chen ZS, Fu LW. Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Research. 70: 7981-91. PMID 20876799 DOI: 10.1158/0008-5472.CAN-10-0111  0.4
2010 Abraham I, Jain S, Wu CP, Khanfar MA, Kuang Y, Dai CL, Shi Z, Chen X, Fu L, Ambudkar SV, El Sayed K, Chen ZS. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Biochemical Pharmacology. 80: 1497-506. PMID 20696137 DOI: 10.1016/j.bcp.2010.08.001  0.32
2010 An X, Tiwari AK, Sun Y, Ding PR, Ashby CR, Chen ZS. BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review. Leukemia Research. 34: 1255-68. PMID 20537386 DOI: 10.1016/j.leukres.2010.04.016  0.4
2010 Tiwari AK, An X, Chen ZS. The role of stem cell markers in multidrug resistance mediated by ABC transporters. Leukemia Research. 34: 696-7. PMID 20061021 DOI: 10.1016/j.leukres.2009.12.007  0.4
2010 Kuang YH, Shen T, Chen X, Sodani K, Hopper-Borge E, Tiwari AK, Lee JW, Fu LW, Chen ZS. Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. Biochemical Pharmacology. 79: 154-61. PMID 19720054 DOI: 10.1016/j.bcp.2009.08.021  0.72
2009 Shen T, Kuang YH, Ashby CR, Lei Y, Chen A, Zhou Y, Chen X, Tiwari AK, Hopper-Borge E, Ouyang J, Chen ZS. Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10). Plos One. 4: e7520. PMID 19841739 DOI: 10.1371/journal.pone.0007520  0.4
2009 Jain S, Abraham I, Carvalho P, Kuang YH, Shaala LA, Youssef DT, Avery MA, Chen ZS, El Sayed KA. Sipholane triterpenoids: chemistry, reversal of ABCB1/P-glycoprotein-mediated multidrug resistance, and pharmacophore modeling. Journal of Natural Products. 72: 1291-8. PMID 19534474 DOI: 10.1021/np900091y  0.36
2009 Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR, Chen X, Chen ZS. Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochemical Pharmacology. 78: 153-61. PMID 19427995 DOI: 10.1016/j.bcp.2009.04.002  0.72
2009 Dai CL, Liang YJ, Chen LM, Zhang X, Deng WJ, Su XD, Shi Z, Wu CP, Ashby CR, Akiyama S, Ambudkar SV, Chen ZS, Fu LW. Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function. Biochemical Pharmacology. 78: 355-64. PMID 19410561 DOI: 10.1016/j.bcp.2009.04.023  0.4
2009 Guo Y, Köck K, Ritter CA, Chen ZS, Grube M, Jedlitschky G, Illmer T, Ayres M, Beck JF, Siegmund W, Ehninger G, Gandhi V, Kroemer HK, Kruh GD, Schaich M. Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 1762-9. PMID 19240178 DOI: 10.1158/1078-0432.CCR-08-0442  0.32
2009 Dai CL, Liang YJ, Wang YS, Tiwari AK, Yan YY, Wang F, Chen ZS, Tong XZ, Fu LW. Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Letters. 279: 74-83. PMID 19232821 DOI: 10.1016/j.canlet.2009.01.027  0.4
2009 Zhou Y, Hopper-Borge E, Shen T, Huang XC, Shi Z, Kuang YH, Furukawa T, Akiyama S, Peng XX, Ashby CR, Chen X, Kruh GD, Chen ZS. Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. Biochemical Pharmacology. 77: 993-1001. PMID 19150344 DOI: 10.1016/j.bcp.2008.12.005  0.4
2009 Shi Z, Parmar S, Peng XX, Shen T, Robey RW, Bates SE, Fu LW, Shao Y, Chen YM, Zang F, Chen ZS. The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance. Oncology Reports. 21: 483-9. PMID 19148526  0.36
2009 Kuang YH, Chen X, Su J, Wu LS, Liao LQ, Li D, Chen ZS, Kanekura T. RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion. Cancer Letters. 276: 189-95. PMID 19097686 DOI: 10.1016/j.canlet.2008.11.010  0.32
2009 Shi Z, Tiwari AK, Shukla S, Robey RW, Kim IW, Parmar S, Bates SE, Si QS, Goldblatt CS, Abraham I, Fu LW, Ambudkar SV, Chen ZS. Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochemical Pharmacology. 77: 781-93. PMID 19059384 DOI: 10.1016/j.bcp.2008.11.007  0.4
2008 Dai CL, Tiwari AK, Wu CP, Su XD, Wang SR, Liu DG, Ashby CR, Huang Y, Robey RW, Liang YJ, Chen LM, Shi CJ, Ambudkar SV, Chen ZS, Fu LW. Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Research. 68: 7905-14. PMID 18829547 DOI: 10.1158/0008-5472.CAN-08-0499  0.4
2008 Kuang YH, Chen X, Su J, Wu LS, Li J, Chang J, Qiu Y, Chen ZS, Kanekura T. Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencing. Journal of Proteome Research. 7: 4784-91. PMID 18816083 DOI: 10.1021/pr800355b  0.32
2008 Peng XX, Shi Z, Damaraju VL, Huang XC, Kruh GD, Wu HC, Zhou Y, Tiwari A, Fu L, Cass CE, Chen ZS. Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine. Leukemia Research. 32: 799-809. PMID 17996297 DOI: 10.1016/j.leukres.2007.09.015  0.36
2007 Shi Z, Peng XX, Kim IW, Shukla S, Si QS, Robey RW, Bates SE, Shen T, Ashby CR, Fu LW, Ambudkar SV, Chen ZS. Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance. Cancer Research. 67: 11012-20. PMID 18006847 DOI: 10.1158/0008-5472.CAN-07-2686  0.4
2007 Shi Z, Jain S, Kim IW, Peng XX, Abraham I, Youssef DT, Fu LW, El Sayed K, Ambudkar SV, Chen ZS. Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Cancer Science. 98: 1373-80. PMID 17640301 DOI: 10.1111/j.1349-7006.2007.00554.x  0.36
2005 Belinsky MG, Dawson PA, Shchaveleva I, Bain LJ, Wang R, Ling V, Chen ZS, Grinberg A, Westphal H, Klein-Szanto A, Lerro A, Kruh GD. Analysis of the in vivo functions of Mrp3. Molecular Pharmacology. 68: 160-8. PMID 15814571 DOI: 10.1124/mol.104.010587  0.32
2005 Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Molecular Pharmacology. 67: 545-57. PMID 15537867 DOI: 10.1124/mol.104.007138  0.32
2003 Guo Y, Kotova E, Chen ZS, Lee K, Hopper-Borge E, Belinsky MG, Kruh GD. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. The Journal of Biological Chemistry. 278: 29509-14. PMID 12764137 DOI: 10.1074/jbc.M304059200  0.32
2003 Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Molecular Pharmacology. 63: 351-8. PMID 12527806 DOI: 10.1124/mol.63.2.351  0.32
2002 Haraguchi M, Tsujimoto H, Fukushima M, Higuchi I, Kuribayashi H, Utsumi H, Nakayama A, Hashizume Y, Hirato J, Yoshida H, Hara H, Hamano S, Kawaguchi H, Furukawa T, Miyazono K, ... ... Chen ZS, et al. Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Molecular and Cellular Biology. 22: 5212-21. PMID 12077348 DOI: 10.1128/MCB.22.14.5212-5221.2002  0.32
2002 Mukai M, Kanzaki A, Chen ZS, Miyashita H, Sumizawa T, Furukawa T, Haraguchi M, Takebayashi Y, Takamatsu H, Akiyama S. Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells. Oncology Reports. 9: 839-44. PMID 12066219  0.32
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