Makarand V. Risbud - Publications

Affiliations: 
Cell and Developmental Biology Thomas Jefferson University 
Area:
Molecular Biology, Cell Biology, General Biology

85 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Tessier S, Madhu V, Johnson ZI, Shapiro IM, Risbud MV. NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis. Developmental Biology. PMID 31301300 DOI: 10.1016/j.ydbio.2019.07.004  0.76
2019 Gorth DJ, Shapiro IM, Risbud MV. A new understanding of the role of IL-1 in age-related intervertebral disc degeneration in a murine model. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 30875127 DOI: 10.1002/jbmr.3714  0.76
2019 Novais EM, Diekman BO, Shapiro IM, Risbud MV. p16 deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 30811968 DOI: 10.1016/j.matbio.2019.02.004  0.76
2018 Gorth DJ, Shapiro IM, Risbud MV. Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration. Cell Death & Disease. 10: 7. PMID 30584238 DOI: 10.1038/s41419-018-1246-x  0.76
2018 Pan H, Strickland A, Madhu V, Johnson ZI, Chand SN, Brody JR, Fertala A, Zheng Z, Shapiro IM, Risbud MV. RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 30092282 DOI: 10.1016/j.matbio.2018.08.003  0.76
2018 Choi H, Chaiyamongkol W, Doolittle AC, Johnson ZI, Gogate SS, Schoepflin ZR, Shapiro IM, Risbud MV. COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus Cells. The Journal of Biological Chemistry. PMID 29700115 DOI: 10.1074/jbc.RA117.001167  0.76
2018 Choi H, Tessier S, Silagi ES, Kyada R, Yousefi F, Pleshko N, Shapiro IM, Risbud MV. A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29605718 DOI: 10.1016/j.matbio.2018.03.019  0.76
2018 Silagi ES, Batista P, Shapiro IM, Risbud MV. Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. Scientific Reports. 8: 4856. PMID 29559661 DOI: 10.1038/s41598-018-23196-7  0.76
2018 Silagi ES, Shapiro IM, Risbud MV. Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc disease. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29501510 DOI: 10.1016/j.matbio.2018.02.025  0.76
2017 Silagi ES, Schoepflin ZR, Seifert EL, Merceron C, Schipani E, Shapiro IM, Risbud MV. Bicarbonate Recycling by HIF-1-dependent Carbonic Anhydrase isoforms 9 and 12 is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 28940640 DOI: 10.1002/jbmr.3293  0.76
2017 Johnson ZI, Doolittle AC, Snuggs JW, Shapiro IM, Le Maitre CL, Risbud MV. TNF-α Promotes Nuclear Enrichment of TonEBP/NFAT5 to Selectively Control Inflammatory but not Osmoregulatory Responses in Nucleus Pulposus Cells. The Journal of Biological Chemistry. PMID 28842479 DOI: 10.1074/jbc.M117.790378  0.76
2017 Liu C, Choi H, Johnson ZI, Tian J, Shapiro IM, Risbud MV. Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus. Scientific Reports. 7: 4543. PMID 28674405 DOI: 10.1038/s41598-017-04876-2  0.76
2017 Schoepflin ZR, Silagi ES, Shapiro IM, Risbud MV. PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28495754 DOI: 10.1096/fj.201601291R  0.76
2016 Johnson ZI, Shapiro IM, Risbud MV. RNA sequencing reveals a role of TonEBP in regulation of pro-inflammatory genes in response to hyperosmolarity in healthy nucleus pulposus cells: A homeostatic response? The Journal of Biological Chemistry. PMID 27875309 DOI: 10.1074/jbc.M116.757732  0.76
2016 Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 0. PMID 27314664 DOI: 10.1080/15548627.2016.1192753  0.76
2016 Suyama K, Silagi ES, Choi H, Sakabe K, Mochida J, Shapiro IM, Risbud MV. Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Oncotarget. PMID 27049729 DOI: 10.18632/oncotarget.8521  0.76
2016 Vo NV, Hartman RA, Patil PR, Risbud MV, Kletsas D, Iatridis JC, Hoyland JA, Le Maitre CL, Sowa GA, Kang JD. Molecular mechanisms of biological aging in intervertebral discs. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 26890203 DOI: 10.1002/jor.23195  0.76
2016 Binch AL, Shapiro IM, Risbud MV. Syndecan-4 in intervertebral disc and cartilage: Saint or synner? Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26796346 DOI: 10.1016/j.matbio.2016.01.005  0.76
2016 Schoepflin ZR, Shapiro IM, Risbud MV. Class I and IIa HDACs Mediate HIF-1α Stability through PHD2-Dependent Mechanism while HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 26765925 DOI: 10.1002/jbmr.2787  0.76
2015 Tian Y, Yuan W, Li J, Wang H, Hunt MG, Liu C, Shapiro IM, Risbud MV. TGFβ regulates galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: Implications in intervertebral disc degeneration. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26639428 DOI: 10.1016/j.matbio.2015.11.008  0.76
2015 Gorth DJ, Shapiro IM, Risbud MV. Discovery of the drivers of inflammation induced chronic low back pain: from bacteria to diabetes. Discovery Medicine. 20: 177-84. PMID 26562470  0.76
2015 Shapiro IM, Landis WJ, Risbud MV. Matrix vesicles: Are they anchored exosomes? Bone. 79: 29-36. PMID 25980744 DOI: 10.1016/j.bone.2015.05.013  0.76
2015 Kepler CK, Markova DZ, Koerner JD, Mendelis J, Chen CM, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG. Substance P Receptor Antagonist Suppresses Inflammatory Cytokine Expression in Human Disc Cells. Spine. PMID 25929203 DOI: 10.1097/BRS.0000000000000954  0.76
2015 Johnson ZI, Gogate SS, Day R, Binch A, Markova DZ, Chiverton N, Cole A, Conner M, Shapiro IM, Le Maitre CL, Risbud MV. Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells. Oncotarget. 6: 11945-58. PMID 25844601  0.76
2015 Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro IM, Risbud MV. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. The Journal of Biological Chemistry. 290: 7195-207. PMID 25635047 DOI: 10.1074/jbc.M114.611483  0.76
2015 Choi H, Johnson ZI, Risbud MV. Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration. Current Stem Cell Research & Therapy. 10: 307-16. PMID 25584906  0.76
2015 Ye W, Zhou J, Markova DZ, Tian Y, Li J, Anderson DG, Shapiro IM, Risbud MV. Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3. The American Journal of Pathology. 185: 485-95. PMID 25476526 DOI: 10.1016/j.ajpath.2014.09.021  0.76
2015 Risbud MV, Schoepflin ZR, Mwale F, Kandel RA, Grad S, Iatridis JC, Sakai D, Hoyland JA. Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 33: 283-93. PMID 25411088 DOI: 10.1002/jor.22789  0.76
2014 Merceron C, Mangiavini L, Robling A, Wilson TL, Giaccia AJ, Shapiro IM, Schipani E, Risbud MV. Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus. Plos One. 9: e110768. PMID 25338007 DOI: 10.1371/journal.pone.0110768  0.76
2014 Johnson ZI, Shapiro IM, Risbud MV. Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP. Matrix Biology : Journal of the International Society For Matrix Biology. 40: 10-6. PMID 25172826 DOI: 10.1016/j.matbio.2014.08.014  0.76
2014 Wang X, Wang H, Yang H, Li J, Cai Q, Shapiro IM, Risbud MV. Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: implications in inflammatory disc disease. The American Journal of Pathology. 184: 2560-72. PMID 25063530 DOI: 10.1016/j.ajpath.2014.06.006  0.76
2014 Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. The Journal of Biological Chemistry. 289: 20594-605. PMID 24867948 DOI: 10.1074/jbc.M114.565101  0.76
2014 Fujita N, Hirose Y, Tran CM, Chiba K, Miyamoto T, Toyama Y, Shapiro IM, Risbud MV. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2455-65. PMID 24558194 DOI: 10.1096/fj.13-243741  0.76
2014 Tran CM, Schoepflin ZR, Markova DZ, Kepler CK, Anderson DG, Shapiro IM, Risbud MV. CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration. The Journal of Biological Chemistry. 289: 7374-87. PMID 24464580 DOI: 10.1074/jbc.M113.526111  0.76
2014 Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nature Reviews. Rheumatology. 10: 44-56. PMID 24166242 DOI: 10.1038/nrrheum.2013.160  0.76
2013 Markova DZ, Kepler CK, Addya S, Murray HB, Vaccaro AR, Shapiro IM, Anderson DG, Albert TJ, Risbud MV. An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes. Arthritis Research & Therapy. 15: R121. PMID 24171898 DOI: 10.1186/ar4301  0.76
2013 Kepler CK, Markova DZ, Hilibrand AS, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG. Substance P stimulates production of inflammatory cytokines in human disc cells. Spine. 38: E1291-9. PMID 23873242 DOI: 10.1097/BRS.0b013e3182a42bc2  0.76
2013 Kepler CK, Markova DZ, Dibra F, Yadla S, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG. Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1β in painful human intervertebral discs. Spine. 38: 873-80. PMID 23660804 DOI: 10.1097/BRS.0b013e318285ae08  0.76
2013 Tian Y, Yuan W, Fujita N, Wang J, Wang H, Shapiro IM, Risbud MV. Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB. The American Journal of Pathology. 182: 2310-21. PMID 23602832 DOI: 10.1016/j.ajpath.2013.02.037  0.76
2013 Wang H, Tian Y, Wang J, Phillips KL, Binch AL, Dunn S, Cross A, Chiverton N, Zheng Z, Shapiro IM, Le Maitre CL, Risbud MV. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. The Journal of Biological Chemistry. 288: 16761-74. PMID 23589286 DOI: 10.1074/jbc.M112.446633  0.76
2013 Tran CM, Shapiro IM, Risbud MV. Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues. Matrix Biology : Journal of the International Society For Matrix Biology. 32: 298-306. PMID 23567513 DOI: 10.1016/j.matbio.2013.03.006  0.76
2013 Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity. The Journal of Biological Chemistry. 288: 12654-66. PMID 23530034 DOI: 10.1074/jbc.M112.448860  0.76
2013 Wang J, Tian Y, Phillips KL, Chiverton N, Haddock G, Bunning RA, Cross AK, Shapiro IM, Le Maitre CL, Risbud MV. Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. Arthritis and Rheumatism. 65: 832-42. PMID 23233369 DOI: 10.1002/art.37819  0.76
2012 Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV. Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling. The Journal of Biological Chemistry. 287: 39942-53. PMID 22948157 DOI: 10.1074/jbc.M112.375964  0.76
2012 Wu Q, Wang J, Skubutyte R, Kepler CK, Huang Z, Anderson DG, Shapiro IM, Risbud MV. Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease. Arthritis and Rheumatism. 64: 3324-33. PMID 22674034 DOI: 10.1002/art.34570  0.76
2012 Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia. The Journal of Biological Chemistry. 287: 16975-86. PMID 22451659 DOI: 10.1074/jbc.M111.334466  0.76
2012 Gogate SS, Fujita N, Skubutyte R, Shapiro IM, Risbud MV. Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: role of Hsp70 in HIF-1α degradation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 1106-17. PMID 22322648 DOI: 10.1002/jbmr.1571  0.76
2012 Shapiro IM, Vresilovic EJ, Risbud MV. Is the spinal motion segment a diarthrodial polyaxial joint: what a nice nucleus like you doing in a joint like this? Bone. 50: 771-6. PMID 22197996 DOI: 10.1016/j.bone.2011.12.004  0.76
2012 Fujita N, Chiba K, Shapiro IM, Risbud MV. HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 401-12. PMID 21987385 DOI: 10.1002/jbmr.538  0.76
2011 Ponnappan RK, Markova DZ, Antonio PJ, Murray HB, Vaccaro AR, Shapiro IM, Anderson DG, Albert TJ, Risbud MV. An organ culture system to model early degenerative changes of the intervertebral disc. Arthritis Research & Therapy. 13: R171. PMID 22018279 DOI: 10.1186/ar3494  0.76
2011 Risbud MV, Shapiro IM. Notochordal cells in the adult intervertebral disc: new perspective on an old question. Critical Reviews in Eukaryotic Gene Expression. 21: 29-41. PMID 21967331  0.76
2011 Wang J, Markova D, Anderson DG, Zheng Z, Shapiro IM, Risbud MV. TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. The Journal of Biological Chemistry. 286: 39738-49. PMID 21949132 DOI: 10.1074/jbc.M111.264549  0.76
2011 Tran CM, Smith HE, Symes A, Rittié L, Perbal B, Shapiro IM, Risbud MV. Transforming growth factor β controls CCN3 expression in nucleus pulposus cells of the intervertebral disc. Arthritis and Rheumatism. 63: 3022-31. PMID 21618206 DOI: 10.1002/art.30468  0.76
2011 Gogate SS, Nasser R, Shapiro IM, Risbud MV. Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins. Arthritis and Rheumatism. 63: 1950-60. PMID 21400481 DOI: 10.1002/art.30342  0.76
2011 Hiyama A, Skubutyte R, Markova D, Anderson DG, Yadla S, Sakai D, Mochida J, Albert TJ, Shapiro IM, Risbud MV. Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease. Arthritis and Rheumatism. 63: 1355-64. PMID 21305512 DOI: 10.1002/art.30246  0.76
2010 Risbud MV, Schaer TP, Shapiro IM. Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 2141-8. PMID 20568241 DOI: 10.1002/dvdy.22350  0.76
2010 Shapiro IM, Risbud MV. Transcriptional profiling of the nucleus pulposus: say yes to notochord. Arthritis Research & Therapy. 12: 117. PMID 20497604 DOI: 10.1186/ar3003  0.76
2010 Skubutyte R, Markova D, Freeman TA, Anderson DG, Dion AS, Williams CJ, Shapiro IM, Risbud MV. Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc. Arthritis and Rheumatism. 62: 2707-15. PMID 20496369 DOI: 10.1002/art.27558  0.76
2010 Tran CM, Markova D, Smith HE, Susarla B, Ponnappan RK, Anderson DG, Symes A, Shapiro IM, Risbud MV. Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling. Arthritis and Rheumatism. 62: 1983-92. PMID 20222112 DOI: 10.1002/art.27445  0.76
2010 Risbud MV, Schipani E, Shapiro IM. Hypoxic regulation of nucleus pulposus cell survival: from niche to notch. The American Journal of Pathology. 176: 1577-83. PMID 20133815 DOI: 10.2353/ajpath.2010.090734  0.76
2010 Hiyama A, Gogate SS, Gajghate S, Mochida J, Shapiro IM, Risbud MV. BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 25: 1179-90. PMID 19961337 DOI: 10.1359/jbmr.091202  0.76
2010 Saraiya M, Nasser R, Zeng Y, Addya S, Ponnappan RK, Fortina P, Anderson DG, Albert TJ, Shapiro IM, Risbud MV. Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells. Tissue Engineering. Part A. 16: 1443-55. PMID 19947906 DOI: 10.1089/ten.TEA.2009.0343  0.76
2009 Cheng CC, Uchiyama Y, Hiyama A, Gajghate S, Shapiro IM, Risbud MV. PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc. Journal of Cellular Physiology. 221: 668-76. PMID 19711351 DOI: 10.1002/jcp.21904  0.76
2009 Hiyama A, Gajghate S, Sakai D, Mochida J, Shapiro IM, Risbud MV. Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc. The Journal of Biological Chemistry. 284: 9824-34. PMID 19147493 DOI: 10.1074/jbc.M807081200  0.76
2009 Gajghate S, Hiyama A, Shah M, Sakai D, Anderson DG, Shapiro IM, Risbud MV. Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 992-1001. PMID 19138132 DOI: 10.1359/jbmr.090103  0.76
2008 Agrawal A, Gajghate S, Smith H, Anderson DG, Albert TJ, Shapiro IM, Risbud MV. Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc. Arthritis and Rheumatism. 58: 3798-808. PMID 19035510 DOI: 10.1002/art.24073  0.76
2008 Uchiyama Y, Guttapalli A, Gajghate S, Mochida J, Shapiro IM, Risbud MV. SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 23: 1619-28. PMID 18466073 DOI: 10.1359/jbmr.080502  0.76
2007 Risbud MV, Guttapalli A, Tsai TT, Lee JY, Danielson KG, Vaccaro AR, Albert TJ, Gazit Z, Gazit D, Shapiro IM. Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine. 32: 2537-44. PMID 17978651 DOI: 10.1097/BRS.0b013e318158dea6  0.76
2007 Uchiyama Y, Cheng CC, Danielson KG, Mochida J, Albert TJ, Shapiro IM, Risbud MV. Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 1996-2006. PMID 17696763 DOI: 10.1359/jbmr.070805  0.76
2007 Zeng Y, Danielson KG, Albert TJ, Shapiro IM, Risbud MV. HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 1851-61. PMID 17592963 DOI: 10.1359/jbmr.070620  0.76
2007 Agrawal A, Guttapalli A, Narayan S, Albert TJ, Shapiro IM, Risbud MV. Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk. American Journal of Physiology. Cell Physiology. 293: C621-31. PMID 17442734 DOI: 10.1152/ajpcell.00538.2006  0.76
2007 Tsai TT, Guttapalli A, Agrawal A, Albert TJ, Shapiro IM, Risbud MV. MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 965-74. PMID 17371162 DOI: 10.1359/jbmr.070322  0.76
2007 Tsai TT, Guttapalli A, Oguz E, Chen LH, Vaccaro AR, Albert TJ, Shapiro IM, Risbud MV. Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro: implications for cell-based transplantation therapy. Spine. 32: 495-502. PMID 17334282 DOI: 10.1097/01.brs.0000257341.88880.f1  0.76
2007 Oguz E, Tsai TT, Di Martino A, Guttapalli A, Albert TJ, Shapiro IM, Risbud MV. Galectin-3 expression in the intervertebral disc: a useful marker of the notochord phenotype? Spine. 32: 9-16. PMID 17202886 DOI: 10.1097/01.brs.0000250302.74574.98  0.76
2006 Tsai TT, Danielson KG, Guttapalli A, Oguz E, Albert TJ, Shapiro IM, Risbud MV. TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc. The Journal of Biological Chemistry. 281: 25416-24. PMID 16772300 DOI: 10.1074/jbc.M601969200  0.76
2006 Risbud MV, Di Martino A, Guttapalli A, Seghatoleslami R, Denaro V, Vaccaro AR, Albert TJ, Shapiro IM. Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling. Spine. 31: 884-90. PMID 16622376 DOI: 10.1097/01.brs.0000209335.57767.b5  0.76
2006 Risbud MV, Guttapalli A, Stokes DG, Hawkins D, Danielson KG, Schaer TP, Albert TJ, Shapiro IM. Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. Journal of Cellular Biochemistry. 98: 152-9. PMID 16408279 DOI: 10.1002/jcb.20765  0.76
2006 Risbud MV, Shapiro IM, Guttapalli A, Di Martino A, Danielson KG, Beiner JM, Hillibrand A, Albert TJ, Anderson DG, Vaccaro AR. Osteogenic potential of adult human stem cells of the lumbar vertebral body and the iliac crest. Spine. 31: 83-9. PMID 16395182  0.76
2005 Anderson DG, Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ. Cell-based therapy for disc repair. The Spine Journal : Official Journal of the North American Spine Society. 5: 297S-303S. PMID 16291126 DOI: 10.1016/j.spinee.2005.02.019  0.76
2005 Risbud MV, Guttapalli A, Albert TJ, Shapiro IM. Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival. Spine. 30: 2503-9. PMID 16284587  0.76
2005 Risbud MV, Fertala J, Vresilovic EJ, Albert TJ, Shapiro IM. Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal. Spine. 30: 882-9. PMID 15834331  0.76
2004 Risbud MV, Albert TJ, Guttapalli A, Vresilovic EJ, Hillibrand AS, Vaccaro AR, Shapiro IM. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Spine. 29: 2627-32. PMID 15564911  0.76
2004 Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ. Stem cell regeneration of the nucleus pulposus. The Spine Journal : Official Journal of the North American Spine Society. 4: 348S-353S. PMID 15541688 DOI: 10.1016/j.spinee.2004.07.031  0.76
2003 Risbud MV, Izzo MW, Adams CS, Arnold WW, Hillibrand AS, Vresilovic EJ, Vaccaro AR, Albert TJ, Shapiro IM. An organ culture system for the study of the nucleus pulposus: description of the system and evaluation of the cells. Spine. 28: 2652-8; discussion 2. PMID 14673364 DOI: 10.1097/01.BRS.0000099384.58981.C6  0.76
2002 Rajpurohit R, Risbud MV, Ducheyne P, Vresilovic EJ, Shapiro IM. Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell and Tissue Research. 308: 401-7. PMID 12107433 DOI: 10.1007/s00441-002-0563-6  0.76
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