Herbert Y. Gaisano - Publications

Affiliations: 
Medical Science University of Toronto, Toronto, ON, Canada 
Area:
Physiology Biology, Cell Biology

98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Jiang J, Cui J, Wang A, Mu Y, Yan Y, Liu F, Pan Y, Li D, Li W, Liu G, Gaisano HY, Dou J, He Y. Association Between Age at Natural Menopause and Risk of Type 2 Diabetes in Postmenopausal Obese and Non-Obese Females. The Journal of Clinical Endocrinology and Metabolism. PMID 30896740 DOI: 10.1210/jc.2018-02310  0.32
2018 Zheng D, Dou J, Liu G, Pan Y, Yan Y, Liu F, Gaisano HY, Lu J, He Y. Association Between Triglyceride Level and Glycemic Control Among Insulin-treated Patients With Type 2 Diabetes. The Journal of Clinical Endocrinology and Metabolism. PMID 30418583 DOI: 10.1210/jc.2018-01656  0.32
2018 Bin NR, Ma K, Tien CW, Wang S, Zhu D, Park S, Turlova E, Sugita K, Shirakawa R, van der Sluijs P, Horiuchi H, Sun HS, Monnier PP, Gaisano HY, Sugita S. C2 Domains of Munc13-4 Are Crucial for Ca-Dependent Degranulation and Cytotoxicity in NK Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 29884704 DOI: 10.4049/jimmunol.1800426  0.36
2018 Greitzer-Antes D, Xie L, Qin T, Xie H, Zhu D, Dolai S, Liang T, Kang F, Hardy AB, He Y, Kang Y, Gaisano HY. Kv2.1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3. The Journal of Biological Chemistry. PMID 29549124 DOI: 10.1074/jbc.RA118.002703  0.4
2018 Dolai S, Liang T, Orabi AI, Holmyard D, Xie L, Greitzer-Antes D, Kang Y, Xie H, Javed TA, Lam PP, Rubin DC, Thorn P, Gaisano HY. Pancreatitis-induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis. Gastroenterology. PMID 29360461 DOI: 10.1053/j.gastro.2018.01.025  0.4
2017 Dolai S, Liang T, Orabi AI, Xie L, Holmyard D, Javed TA, Fernandez NA, Xie H, Cattral MS, Thurmond DC, Thorn P, Gaisano HY. Munc18c depletion attenuates caerulein hyperstimulation induced pancreatitis. The Journal of Biological Chemistry. PMID 29284677 DOI: 10.1074/jbc.RA117.000792  0.4
2017 Liang T, Dolai S, Xie L, Winter E, Orabi AI, Karimian N, Cosen-Binker LI, Huang YC, Thorn P, Cattral M, Gaisano HY. Ex Vivo Human Pancreatic Slice Preparations Offer a Valuable Model for Studying Pancreatic Exocrine Biology. The Journal of Biological Chemistry. PMID 28242761 DOI: 10.1074/jbc.M117.777433  0.56
2017 Qin T, Liang T, Zhu D, Kang Y, Xie L, Dolai S, Sugita S, Takahashi N, Ostenson CG, Banks K, Gaisano HY. Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis. Ebiomedicine. PMID 28163042 DOI: 10.1016/j.ebiom.2017.01.030  0.4
2017 Zhu D, Xie L, Kang Y, Dolai S, Hansen JB, Qin T, Xie H, Liang T, Rubin DC, Osborne L, Gaisano HY. Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis. Diabetes. PMID 28115395 DOI: 10.2337/db16-0636  0.4
2017 Pan Y, Jing J, Chen W, Zheng H, Jia Q, Mi D, Li H, Zhao X, Liu L, Wang C, Gaisano HY, He Y, Wang Y, Wang Y. Post-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke. Journal of the American Heart Association. 6. PMID 28108466 DOI: 10.1161/JAHA.116.004990  0.32
2016 Liang T, Qin T, Xie L, Dolai S, Zhu D, Prentice KJ, Wheeler M, Kang Y, Osborne L, Gaisano HY. New roles of Syntaxin-1A in insulin granule exocytosis and replenishment. The Journal of Biological Chemistry. PMID 28031464 DOI: 10.1074/jbc.M116.769885  0.4
2016 Dolai S, Xie L, Zhu D, Liang T, Qin T, Xie H, Kang Y, Chapman ER, Gaisano HY. Synaptotagmin-7 functions to replenish insulin granules for exocytosis in human islet β-cell. Diabetes. PMID 27207520 DOI: 10.2337/db15-1436  0.56
2016 Pan Y, Wang Y, Li H, Gaisano HY, Wang Y, He Y. Association of Diabetes and Prognosis of Minor Stroke and Its Subtypes: A Prospective Observational Study. Plos One. 11: e0153178. PMID 27070309 DOI: 10.1371/journal.pone.0153178  0.32
2016 Xie L, Dolai S, Kang Y, Liang T, Xie H, Qin T, Yang L, Chen L, Gaisano HY. Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells. Plos One. 11: e0147862. PMID 26848587 DOI: 10.1371/journal.pone.0147862  0.56
2015 Almaça J, Liang T, Gaisano HY, Nam HG, Berggren PO, Caicedo A. Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets. Diabetologia. PMID 26376795 DOI: 10.1007/s00125-015-3747-9  0.56
2015 Binker MG, Richards D, Gaisano HY, Cosen-Binker LI. ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation. Biochemical and Biophysical Research Communications. 463: 329-35. PMID 26022124 DOI: 10.1016/j.bbrc.2015.05.064  0.56
2015 Zhu D, Xie L, Karimian N, Liang T, Kang Y, Huang YC, Gaisano HY. Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells. Molecular Metabolism. 4: 418-26. PMID 25973389 DOI: 10.1016/j.molmet.2015.02.004  0.56
2015 Bin NR, Jung CH, Kim B, Chandrasegram P, Turlova E, Zhu D, Gaisano HY, Sun HS, Sugita S. Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis. Journal of Cell Science. 128: 1946-60. PMID 25795302 DOI: 10.1242/jcs.165662  0.36
2015 Xie L, Zhu D, Dolai S, Liang T, Qin T, Kang Y, Xie H, Huang YC, Gaisano HY. Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells. Diabetologia. 58: 1250-9. PMID 25762204 DOI: 10.1007/s00125-015-3545-4  0.56
2015 Wang L, Luk CT, Cai EP, Schroer SA, Allister EM, Shi SY, Wheeler MB, Gaisano HY, Woo M. PTEN deletion in pancreatic α-cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance. Diabetes. 64: 147-57. PMID 25092678 DOI: 10.2337/db13-1715  0.56
2014 Xie L, Liang T, Kang Y, Lin X, Sobbi R, Xie H, Chao C, Backx P, Feng ZP, Shyng SL, Gaisano HY. Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels. Journal of Molecular and Cellular Cardiology. 75: 100-10. PMID 25073062 DOI: 10.1016/j.yjmcc.2014.07.012  0.56
2014 Zhang M, Robitaille M, Showalter AD, Huang X, Liu Y, Bhattacharjee A, Willard FS, Han J, Froese S, Wei L, Gaisano HY, Angers S, Sloop KW, Dai FF, Wheeler MB. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Molecular & Cellular Proteomics : McP. 13: 3049-62. PMID 25044020 DOI: 10.1074/mcp.M114.040196  0.56
2014 Low JT, Zavortink M, Mitchell JM, Gan WJ, Do OH, Schwiening CJ, Gaisano HY, Thorn P. Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature. Diabetologia. 57: 1655-63. PMID 24795086 DOI: 10.1007/s00125-014-3252-6  0.56
2014 Do OH, Low JT, Gaisano HY, Thorn P. The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells. Diabetologia. 57: 1400-9. PMID 24705605 DOI: 10.1007/s00125-014-3226-8  0.56
2014 Banks K, Qin T, Liang T, Wang AJ, Gaisano HY. Biliopancreatic route for effective viral transduction of pancreatic islets. Pancreas. 43: 240-4. PMID 24518502 DOI: 10.1097/MPA.0000000000000096  0.36
2014 Liang T, Xie L, Chao C, Kang Y, Lin X, Qin T, Xie H, Feng ZP, Gaisano HY. Phosphatidylinositol 4,5-biphosphate (PIP2) modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-cell ATP-sensitive potassium channels. The Journal of Biological Chemistry. 289: 6028-40. PMID 24429282 DOI: 10.1074/jbc.M113.511808  0.56
2014 Li SK, Zhu D, Gaisano HY, Brubaker PL. Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell. Diabetologia. 57: 809-18. PMID 24356748 DOI: 10.1007/s00125-013-3143-2  0.56
2013 Low JT, Mitchell JM, Do OH, Bax J, Rawlings A, Zavortink M, Morgan G, Parton RG, Gaisano HY, Thorn P. Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell. Diabetologia. 56: 2629-37. PMID 23995471 DOI: 10.1007/s00125-013-3019-5  0.56
2013 Xie L, Zhu D, Kang Y, Liang T, He Y, Gaisano HY. Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. Plos One. 8: e67561. PMID 23844030 DOI: 10.1371/journal.pone.0067561  0.4
2013 Karimian N, Qin T, Liang T, Osundiji M, Huang Y, Teich T, Riddell MC, Cattral MS, Coy DH, Vranic M, Gaisano HY. Somatostatin receptor type 2 antagonism improves glucagon counterregulation in biobreeding diabetic rats. Diabetes. 62: 2968-77. PMID 23630299 DOI: 10.2337/db13-0164  0.36
2013 Allister EM, Robson-Doucette CA, Prentice KJ, Hardy AB, Sultan S, Gaisano HY, Kong D, Gilon P, Herrera PL, Lowell BB, Wheeler MB. UCP2 regulates the glucagon response to fasting and starvation. Diabetes. 62: 1623-33. PMID 23434936 DOI: 10.2337/db12-0981  0.56
2013 Lam PP, Ohno M, Dolai S, He Y, Qin T, Liang T, Zhu D, Kang Y, Liu Y, Kauppi M, Xie L, Wan WC, Bin NR, Sugita S, Olkkonen VM, ... ... Gaisano HY, et al. Munc18b is a major mediator of insulin exocytosis in rat pancreatic β-cells. Diabetes. 62: 2416-28. PMID 23423569 DOI: 10.2337/db12-1380  0.56
2013 Xie L, Kang Y, Liang T, Dolai S, Xie H, Parsaud L, Lopez JA, He Y, Chidambaram S, Lam PP, James DE, Sugita S, Gaisano HY. RalA GTPase tethers insulin granules to L- and R-type calcium channels through binding α2 δ-1 subunit. Traffic (Copenhagen, Denmark). 14: 428-39. PMID 23346930 DOI: 10.1111/tra.12047  0.56
2013 Huang YC, Rupnik MS, Karimian N, Herrera PL, Gilon P, Feng ZP, Gaisano HY. In situ electrophysiological examination of pancreatic α cells in the streptozotocin-induced diabetes model, revealing the cellular basis of glucagon hypersecretion. Diabetes. 62: 519-30. PMID 23043159 DOI: 10.2337/db11-0786  0.56
2012 Zhu D, Zhang Y, Lam PP, Dolai S, Liu Y, Cai EP, Choi D, Schroer SA, Kang Y, Allister EM, Qin T, Wheeler MB, Wang CC, Hong WJ, Woo M, ... Gaisano HY, et al. Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth. Cell Metabolism. 16: 238-49. PMID 22841572 DOI: 10.1016/j.cmet.2012.07.001  0.56
2012 Dolai S, Liang T, Lam PP, Fernandez NA, Chidambaram S, Gaisano HY. Effects of ethanol metabolites on exocytosis of pancreatic acinar cells in rats. Gastroenterology. 143: 832-43.e1-7. PMID 22710192 DOI: 10.1053/j.gastro.2012.06.011  0.56
2012 Cai EP, Casimir M, Schroer SA, Luk CT, Shi SY, Choi D, Dai XQ, Hajmrle C, Spigelman AF, Zhu D, Gaisano HY, MacDonald PE, Woo M. In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking. Diabetes. 61: 1708-18. PMID 22498697 DOI: 10.2337/db11-1344  0.56
2011 Chao C, Liang T, Kang Y, Lin X, Xie H, Feng ZP, Gaisano HY. Syntaxin-1A inhibits KATP channels by interacting with specific conserved motifs within sulfonylurea receptor 2A. Journal of Molecular and Cellular Cardiology. 51: 790-802. PMID 21884702 DOI: 10.1016/j.yjmcc.2011.08.011  0.56
2011 Behrendorff N, Dolai S, Hong W, Gaisano HY, Thorn P. Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion. The Journal of Biological Chemistry. 286: 29627-34. PMID 21733851 DOI: 10.1074/jbc.M111.265199  0.56
2011 Huang YC, Gaisano HY, Leung YM. Electrophysiological identification of mouse islet α-cells: from isolated single α-cells to in situ assessment within pancreas slices. Islets. 3: 139-43. PMID 21623173 DOI: 10.4161/isl.3.4.16166  0.56
2011 Chang N, Liang T, Lin X, Kang Y, Xie H, Feng ZP, Gaisano HY. Syntaxin-1A interacts with distinct domains within nucleotide-binding folds of sulfonylurea receptor 1 to inhibit beta-cell ATP-sensitive potassium channels. The Journal of Biological Chemistry. 286: 23308-18. PMID 21540180 DOI: 10.1074/jbc.M111.217950  0.56
2011 Fernandez NA, Liang T, Gaisano HY. Live pancreatic acinar imaging of exocytosis using syncollin-pHluorin. American Journal of Physiology. Cell Physiology. 300: C1513-23. PMID 21307342 DOI: 10.1152/ajpcell.00433.2010  0.36
2011 Dai XQ, Plummer G, Casimir M, Kang Y, Hajmrle C, Gaisano HY, Manning Fox JE, MacDonald PE. SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans Diabetes. 60: 838-847. PMID 21266332 DOI: 10.2337/db10-0440  0.56
2011 Chen PC, Bruederle CE, Gaisano HY, Shyng SL. Syntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels. American Journal of Physiology. Cell Physiology. 300: C506-16. PMID 21209369 DOI: 10.1152/ajpcell.00429.2010  0.56
2011 Kang Y, Zhang Y, Liang T, Leung YM, Ng B, Xie H, Chang N, Chan J, Shyng SL, Tsushima RG, Gaisano HY. ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channels. The Journal of Biological Chemistry. 286: 5876-83. PMID 21173146 DOI: 10.1074/jbc.M109.089607  0.56
2011 Chao CC, Mihic A, Tsushima RG, Gaisano HY. SNARE protein regulation of cardiac potassium channels and atrial natriuretic factor secretion. Journal of Molecular and Cellular Cardiology. 50: 401-7. PMID 21129378 DOI: 10.1016/j.yjmcc.2010.11.018  0.4
2011 Huang YC, Rupnik M, Gaisano HY. Unperturbed islet α-cell function examined in mouse pancreas tissue slices. The Journal of Physiology. 589: 395-408. PMID 21078586 DOI: 10.1113/jphysiol.2010.200345  0.56
2010 L'Heureux MC, Muinuddin A, Gaisano HY, Diamant NE. Nitric oxide activation of a potassium channel (BK(Ca)) in feline lower esophageal sphincter. World Journal of Gastroenterology. 16: 5852-60. PMID 21155007 DOI: 10.3748/wjg.v16.i46.5852  0.56
2010 Choi D, Schroer SA, Lu SY, Wang L, Wu X, Liu Y, Zhang Y, Gaisano HY, Wagner KU, Wu H, Retnakaran R, Woo M. Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. The Journal of Experimental Medicine. 207: 2831-42. PMID 21149549 DOI: 10.1084/jem.20100665  0.32
2009 Han L, Jiang T, Han GA, Malintan NT, Xie L, Wang L, Tse FW, Gaisano HY, Collins BM, Meunier FA, Sugita S. Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells. Molecular Biology of the Cell. 20: 4962-75. PMID 19812250 DOI: 10.1091/mbc.E09-08-0712  0.56
2009 Choi D, Radziszewska A, Schroer SA, Liadis N, Liu Y, Zhang Y, Lam PP, Sheu L, Hao Z, Gaisano HY, Woo M. Deletion of Fas in the pancreatic beta-cells leads to enhanced insulin secretion. American Journal of Physiology. Endocrinology and Metabolism. 297: E1304-12. PMID 19755672 DOI: 10.1152/ajpendo.00217.2009  0.4
2009 Zhang Y, Liu Y, Qu J, Hardy A, Zhang N, Diao J, Strijbos PJ, Tsushima R, Robinson RB, Gaisano HY, Wang Q, Wheeler MB. Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells. The Journal of Endocrinology. 203: 45-53. PMID 19654142 DOI: 10.1677/JOE-09-0068  0.32
2009 Wang P, Wang Q, Sun J, Wu J, Li H, Zhang N, Huang Y, Su B, Li RK, Liu L, Zhang Y, Elsholtz HP, Hu J, Gaisano HY, Jin T. POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP. The Journal of Biological Chemistry. 284: 26456-65. PMID 19617623 DOI: 10.1074/jbc.M109.030668  0.32
2009 Vikman J, Svensson H, Huang YC, Kang Y, Andersson SA, Gaisano HY, Eliasson L. Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells. American Journal of Physiology. Endocrinology and Metabolism. 297: E452-61. PMID 19509185 DOI: 10.1152/ajpendo.90585.2008  0.56
2009 Zhang Y, Kang YH, Chang N, Lam PP, Liu Y, Olkkonen VM, Gaisano HY. Cab45b, a Munc18b-interacting partner, regulates exocytosis in pancreatic beta-cells. The Journal of Biological Chemistry. 284: 20840-7. PMID 19487699 DOI: 10.1074/jbc.M109.017467  0.32
2009 Gaisano HY, Gorelick FS. New insights into the mechanisms of pancreatitis. Gastroenterology. 136: 2040-4. PMID 19379751 DOI: 10.1053/j.gastro.2009.04.023  0.56
2009 Masson E, Koren S, Razik F, Goldberg H, Kwan EP, Sheu L, Gaisano HY, Fantus IG. High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice. American Journal of Physiology. Endocrinology and Metabolism. 296: E1251-61. PMID 19223654 DOI: 10.1152/ajpendo.90619.2008  0.56
2009 Kwan EP, Gaisano HY. Rescuing the subprime meltdown in insulin exocytosis in diabetes. Annals of the New York Academy of Sciences. 1152: 154-64. PMID 19161386 DOI: 10.1111/j.1749-6632.2008.03990.x  0.56
2008 Ng B, Kang Y, Xie H, Sun H, Gaisano HY. Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel. Cardiovascular Research. 80: 365-74. PMID 18703534 DOI: 10.1093/cvr/cvn210  0.4
2008 Xia F, Xie L, Mihic A, Gao X, Chen Y, Gaisano HY, Tsushima RG. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 149: 5136-45. PMID 18599549 DOI: 10.1210/en.2008-0161  0.4
2008 Gaisano HY, Leung YM. Pancreatic islet alpha cell commands itself: secrete more glucagon! Cell Metabolism. 7: 474-5. PMID 18522828 DOI: 10.1016/j.cmet.2008.05.003  0.56
2008 Lopez JA, Kwan EP, Xie L, He Y, James DE, Gaisano HY. The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells. The Journal of Biological Chemistry. 283: 17939-45. PMID 18426794 DOI: 10.1074/jbc.M800321200  0.56
2008 Cosen-Binker LI, Morris GP, Vanner S, Gaisano HY. Munc18/SNARE proteins' regulation of exocytosis in guinea pig duodenal Brunner's gland acini. World Journal of Gastroenterology. 14: 2314-22. PMID 18416456 DOI: 10.3748/wjg.14.2314  0.56
2008 Webster NJ, Searle GJ, Lam PP, Huang YC, Riedel MJ, Harb G, Gaisano HY, Holt A, Light PE. Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels. Endocrinology. 149: 3679-87. PMID 18372336 DOI: 10.1210/en.2007-1138  0.56
2008 He Y, Elias CL, Huang YC, Gao X, Leung YM, Kang Y, Xie H, Chaddock JA, Tsushima RG, Gaisano HY. Botulinum neurotoxin A and neurotoxin E cleavage products of synaptosome-associated protein of 25 kd exhibit distinct actions on pancreatic islet beta-cell Kv2.1 channel gating. Pancreas. 36: 10-7. PMID 18192874 DOI: 10.1097/mpa.0b013e31812eee28  0.56
2008 Arunachalam L, Han L, Tassew NG, He Y, Wang L, Xie L, Fujita Y, Kwan E, Davletov B, Monnier PP, Gaisano HY, Sugita S. Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells. Molecular Biology of the Cell. 19: 722-34. PMID 18077557 DOI: 10.1091/mbc.E07-07-0662  0.56
2007 Leung YM, Kwan EP, Ng B, Kang Y, Gaisano HY. SNAREing Voltage-Gated K+ and ATP-Sensitive K+ Channels: Tuning β-Cell Excitability with Syntaxin-1A and Other Exocytotic Proteins. Endocrine Reviews. 28: 653-663. PMID 28199496 DOI: 10.1210/er.2007-0010  0.56
2007 Kwan EP, Gao X, Leung YM, Gaisano HY. Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells. Pancreas. 35: e45-54. PMID 17895835 DOI: 10.1097/mpa.0b013e318073d1c9  0.56
2007 Leung YM, Kwan EP, Ng B, Kang Y, Gaisano HY. SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins. Endocrine Reviews. 28: 653-63. PMID 17878408 DOI: 10.1210/er.2007-0010  0.56
2007 Min L, Leung YM, Tomas A, Watson RT, Gaisano HY, Halban PA, Pessin JE, Hou JC. Dynamin is functionally coupled to insulin granule exocytosis. The Journal of Biological Chemistry. 282: 33530-6. PMID 17848579 DOI: 10.1074/jbc.M703402200  0.56
2007 Yamakawa T, Saith S, Li Y, Gao X, Gaisano HY, Tsushima RG. Interaction of syntaxin 1A with the N-terminus of Kv4.2 modulates channel surface expression and gating. Biochemistry. 46: 10942-9. PMID 17725325 DOI: 10.1021/bi7006806  0.4
2007 Kwan EP, Xie L, Sheu L, Ohtsuka T, Gaisano HY. Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells. Diabetes. 56: 2579-88. PMID 17639022 DOI: 10.2337/db06-1207  0.56
2007 Liadis N, Salmena L, Kwan E, Tajmir P, Schroer SA, Radziszewska A, Li X, Sheu L, Eweida M, Xu S, Gaisano HY, Hakem R, Woo M. Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models. Diabetes. 56: 2302-11. PMID 17563067 DOI: 10.2337/db06-1771  0.56
2007 Fujita Y, Xu A, Xie L, Arunachalam L, Chou TC, Jiang T, Chiew SK, Kourtesis J, Wang L, Gaisano HY, Sugita S. Ca2+-dependent activator protein for secretion 1 is critical for constitutive and regulated exocytosis but not for loading of transmitters into dense core vesicles. The Journal of Biological Chemistry. 282: 21392-403. PMID 17540763 DOI: 10.1074/jbc.M703699200  0.36
2007 Ahmed I, Cosen-Binker LI, Leung YM, Gaisano HY, Diamant NE. Modulation of the K(v)4.3 channel by syntaxin 1A. Biochemical and Biophysical Research Communications. 358: 789-95. PMID 17506992 DOI: 10.1016/j.bbrc.2007.04.182  0.56
2007 Ng B, Kang Y, Elias CL, He Y, Xie H, Hansen JB, Wahl P, Gaisano HY. The actions of a novel potent islet beta-cell specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1. Diabetes. 56: 2124-34. PMID 17496234 DOI: 10.2337/db07-0030  0.4
2007 Ostenson CG, Chen J, Sheu L, Gaisano HY. Effects of palmitate on insulin secretion and exocytotic proteins in islets of diabetic Goto-Kakizaki rats. Pancreas. 34: 359-63. PMID 17414060 DOI: 10.1097/MPA.0b013e3180304825  0.4
2007 Xia F, Leung YM, Gaisano G, Gao X, Chen Y, Fox JE, Bhattacharjee A, Wheeler MB, Gaisano HY, Tsushima RG. Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling. Endocrinology. 148: 2157-67. PMID 17303668 DOI: 10.1210/en.2006-1296  0.56
2007 Neshatian L, Leung YM, Kang Y, Gao X, Xie H, Tsushima RG, Gaisano HY, Diamant NE. Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A. American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G1233-42. PMID 17234891 DOI: 10.1152/ajpgi.00473.2006  0.56
2006 Wolf-Goldberg T, Michaelevski I, Sheu L, Gaisano HY, Chikvashvili D, Lotan I. Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNARES) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels Molecular Pharmacology. 70: 818-828. PMID 16754785 DOI: 10.1124/mol.105.021717  0.56
2006 Dai FF, Zhang Y, Kang Y, Wang Q, Gaisano HY, Braunewell KH, Chan CB, Wheeler MB. The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. The Journal of Biological Chemistry. 281: 21942-53. PMID 16731532 DOI: 10.1074/jbc.M512924200  0.56
2006 Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, Gaisano HY. Two populations of pancreatic islet alpha-cells displaying distinct Ca2+ channel properties. Biochemical and Biophysical Research Communications. 345: 340-4. PMID 16678791 DOI: 10.1016/j.bbrc.2006.04.066  0.56
2006 Kang Y, Ng B, Leung YM, He Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG, Gaisano HY. Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation. The Journal of Biological Chemistry. 281: 19019-28. PMID 16672225 DOI: 10.1074/jbc.M513160200  0.56
2006 Lotfi S, Li Z, Sun J, Zuo Y, Lam PP, Kang Y, Rahimi M, Islam D, Wang P, Gaisano HY, Jin T. Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells. Endocrinology. 147: 3727-36. PMID 16644915 DOI: 10.1210/en.2006-0056  0.56
2006 Kwan EP, Xie L, Sheu L, Nolan CJ, Prentki M, Betz A, Brose N, Gaisano HY. Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes. 55: 1421-9. PMID 16644700 DOI: 10.2337/db05-1263  0.56
2006 Chai Y, Huang X, Cong B, Liu S, Chen K, Li G, Gaisano HY. Involvement of VAMP-2 in exocytosis of IL-1 beta in turbot (Scophthalmus maximus) leukocytes after Vibrio anguillarum infection. Biochemical and Biophysical Research Communications. 342: 509-13. PMID 16487935 DOI: 10.1016/j.bbrc.2006.01.138  0.32
2006 He Y, Kang Y, Leung YM, Xia F, Gao X, Xie H, Gaisano HY, Tsushima RG. Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25. The Biochemical Journal. 396: 363-9. PMID 16478442 DOI: 10.1042/BJ20051478  0.56
2006 Leung YM, Ahmed I, Sheu L, Gao X, Hara M, Tsushima RG, Diamant NE, Gaisano HY. Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition. Endocrinology. 147: 2155-62. PMID 16455778 DOI: 10.1210/en.2005-1249  0.56
2006 L'Heureux MC, Muinuddin A, Gaisano HY, Diamant NE. Feline lower esophageal sphincter sling and circular muscles have different functional inhibitory neuronal responses. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G23-9. PMID 16166343 DOI: 10.1152/ajpgi.00303.2005  0.56
2005 Lam PP, Leung YM, Sheu L, Ellis J, Tsushima RG, Osborne LR, Gaisano HY. Transgenic mouse overexpressing syntaxin-1A as a diabetes model. Diabetes. 54: 2744-54. PMID 16123365  0.56
2005 Kwan EP, Gaisano HY. Glucagon-like peptide 1 regulates sequential and compound exocytosis in pancreatic islet beta-cells. Diabetes. 54: 2734-43. PMID 16123364 DOI: 10.2337/diabetes.54.9.2734  0.56
2005 Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, Hara M, Gaisano HY. Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse. Endocrinology. 146: 4766-75. PMID 16109783 DOI: 10.1210/en.2005-0803  0.56
2005 Liadis N, Murakami K, Eweida M, Elford AR, Sheu L, Gaisano HY, Hakem R, Ohashi PS, Woo M. Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Molecular and Cellular Biology. 25: 3620-9. PMID 15831467 DOI: 10.1128/MCB.25.9.3620-3629.2005  0.56
2005 Muinuddin A, Naqvi K, Sheu L, Gaisano HY, Diamant NE. Regional differences in cholinergic regulation of potassium current in feline esophageal circular smooth muscle. American Journal of Physiology. Gastrointestinal and Liver Physiology. 288: G1233-40. PMID 15691872 DOI: 10.1152/ajpgi.00310.2004  0.56
2005 Leung YM, Kang Y, Xia F, Sheu L, Gao X, Xie H, Tsushima RG, Gaisano HY. Open form of syntaxin-1A is a more potent inhibitor than wild-type syntaxin-1A of Kv2.1 channels. The Biochemical Journal. 387: 195-202. PMID 15518587 DOI: 10.1042/BJ20041625  0.56
2004 Cui N, Kang Y, He Y, Leung YM, Xie H, Pasyk EA, Gao X, Sheu L, Hansen JB, Wahl P, Tsushima RG, Gaisano HY. H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2. The Journal of Biological Chemistry. 279: 53259-65. PMID 15485808 DOI: 10.1074/jbc.M410171200  0.56
2004 Kang Y, Leung YM, Manning-Fox JE, Xia F, Xie H, Sheu L, Tsushima RG, Light PE, Gaisano HY. Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A. The Journal of Biological Chemistry. 279: 47125-31. PMID 15339904 DOI: 10.1074/jbc.M404954200  0.56
2004 Muinuddin A, Kang Y, Gaisano HY, Diamant NE. Regional differences in L-type Ca2+ channel expression in feline lower esophageal sphincter. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G772-81. PMID 15178551 DOI: 10.1152/ajpgi.00102.2004  0.56
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