Joseph L. Witztum - Publications

Affiliations: 
Biomedical Sciences University of California, San Diego, La Jolla, CA 
Area:
Physiology Biology, Molecular Biology

92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, ... ... Witztum JL, et al. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. PMID 30013121 DOI: 10.1038/s41586-018-0313-x  0.52
2018 Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, ... ... Witztum JL, et al. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. PMID 29875409 DOI: 10.1038/s41586-018-0198-8  0.52
2016 Binder CJ, Papac-Milicevic N, Witztum JL. Innate sensing of oxidation-specific epitopes in health and disease. Nature Reviews. Immunology. PMID 27346802 DOI: 10.1038/nri.2016.63  0.52
2016 Gruber S, Hendrikx T, Tsiantoulas D, Ozsvar-Kozma M, Göderle L, Mallat Z, Witztum JL, Shiri-Sverdlov R, Nitschke L, Binder CJ. Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells. Cell Reports. 14: 2348-61. PMID 26947073 DOI: 10.1016/j.celrep.2016.02.027  0.52
2015 Gaudet D, Alexander VJ, Baker BF, Brisson D, Tremblay K, Singleton W, Geary RS, Hughes SG, Viney NJ, Graham MJ, Crooke RM, Witztum JL, Brunzell JD, Kastelein JJ. Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. The New England Journal of Medicine. 373: 438-47. PMID 26222559 DOI: 10.1056/NEJMoa1400283  0.52
2015 Tsimikas S, Viney NJ, Hughes SG, Singleton W, Graham MJ, Baker BF, Burkey JL, Yang Q, Marcovina SM, Geary RS, Crooke RM, Witztum JL. Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study. Lancet (London, England). 386: 1472-83. PMID 26210642 DOI: 10.1016/S0140-6736(15)61252-1  0.52
2015 Rosenfeld SM, Perry HM, Gonen A, Prohaska TA, Srikakulapu P, Grewal S, Das D, McSkimming C, Taylor AM, Tsimikas S, Bender TP, Witztum JL, McNamara CA. B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. Circulation Research. 117: e28-39. PMID 26082558 DOI: 10.1161/CIRCRESAHA.117.306044  0.52
2015 Byun YS, Lee JH, Arsenault BJ, Yang X, Bao W, DeMicco D, Laskey R, Witztum JL, Tsimikas S. Relationship of oxidized phospholipids on apolipoprotein B-100 to cardiovascular outcomes in patients treated with intensive versus moderate atorvastatin therapy: the TNT trial. Journal of the American College of Cardiology. 65: 1286-95. PMID 25835440 DOI: 10.1016/j.jacc.2015.01.050  0.52
2015 Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, ... ... Witztum JL, et al. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Journal of Lipid Research. 56: 722-36. PMID 25598080 DOI: 10.1194/jlr.P056002  0.52
2015 Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska TA, Papac-Milicevic N, Millischer V, Bartel C, Hörkkö S, Boulanger CM, Tsimikas S, Fischer MB, Witztum JL, Lang IM, Binder CJ. Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. Journal of Lipid Research. 56: 440-8. PMID 25525116 DOI: 10.1194/jlr.P054569  0.52
2015 Pechlaner R, Willeit P, Summerer M, Santer P, Egger G, Kronenberg F, Demetz E, Weiss G, Tsimikas S, Witztum JL, Willeit K, Iglseder B, Paulweber B, Kedenko L, Haun M, et al. Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 229-36. PMID 25359861 DOI: 10.1161/ATVBAHA.114.304729  0.52
2014 Gaudet D, Brisson D, Tremblay K, Alexander VJ, Singleton W, Hughes SG, Geary RS, Baker BF, Graham MJ, Crooke RM, Witztum JL. Targeting APOC3 in the familial chylomicronemia syndrome. The New England Journal of Medicine. 371: 2200-6. PMID 25470695 DOI: 10.1056/NEJMoa1400284  0.52
2014 Gordts PL, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metabolism. 20: 813-26. PMID 25440058 DOI: 10.1016/j.cmet.2014.09.016  0.52
2014 Willeit P, Raschenberger J, Heydon EE, Tsimikas S, Haun M, Mayr A, Weger S, Witztum JL, Butterworth AS, Willeit J, Kronenberg F, Kiechl S. Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis. Plos One. 9: e112483. PMID 25390655 DOI: 10.1371/journal.pone.0112483  0.52
2014 Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL, Tarling EJ. ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. Journal of Immunology (Baltimore, Md. : 1950). 193: 5637-48. PMID 25339664 DOI: 10.4049/jimmunol.1400606  0.52
2014 Briley-Saebo K, Yeang C, Witztum JL, Tsimikas S. Imaging of oxidation-specific epitopes with targeted nanoparticles to detect high-risk atherosclerotic lesions: progress and future directions. Journal of Cardiovascular Translational Research. 7: 719-36. PMID 25297940 DOI: 10.1007/s12265-014-9590-4  0.52
2014 Willeit P, Kiechl S, Kronenberg F, Witztum JL, Santer P, Mayr M, Xu Q, Mayr A, Willeit J, Tsimikas S. Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study. Journal of the American College of Cardiology. 64: 851-60. PMID 25169167 DOI: 10.1016/j.jacc.2014.03.061  0.52
2014 Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K. Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine. Journal of Lipid Research. 55: 2137-55. PMID 25143462 DOI: 10.1194/jlr.M053256  0.52
2014 Tsiantoulas D, Diehl CJ, Witztum JL, Binder CJ. B cells and humoral immunity in atherosclerosis. Circulation Research. 114: 1743-56. PMID 24855199 DOI: 10.1161/CIRCRESAHA.113.301145  0.52
2014 Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum JL, Tsimikas S. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. Journal of the American College of Cardiology. 63: 1961-71. PMID 24613321 DOI: 10.1016/j.jacc.2014.01.055  0.52
2014 Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, ... Witztum JL, et al. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation. 129: 1677-87. PMID 24488984 DOI: 10.1161/CIRCULATIONAHA.113.006381  0.52
2014 Witztum JL, Lichtman AH. The influence of innate and adaptive immune responses on atherosclerosis. Annual Review of Pathology. 9: 73-102. PMID 23937439 DOI: 10.1146/annurev-pathol-020712-163936  0.52
2013 Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum JL, Miller YI. Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. Plos One. 8: e83145. PMID 24376657 DOI: 10.1371/journal.pone.0083145  0.52
2013 Perry HM, Oldham SN, Fahl SP, Que X, Gonen A, Harmon DB, Tsimikas S, Witztum JL, Bender TP, McNamara CA. Helix-loop-helix factor inhibitor of differentiation 3 regulates interleukin-5 expression and B-1a B cell proliferation. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2771-9. PMID 24115031 DOI: 10.1161/ATVBAHA.113.302571  0.52
2013 Montano EN, Boullier A, Almazan F, Binder CJ, Witztum JL, Hartvigsen K. Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors Journal of Lipid Research. 54: 3206-3214. PMID 23997238 DOI: 10.1194/jlr.D040923  0.52
2013 Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum JL, Haddad GG, Li AC. Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice. Journal of Applied Physiology (Bethesda, Md. : 1985). 115: 1694-704. PMID 23990245 DOI: 10.1152/japplphysiol.00442.2013  0.52
2013 Que X, Widhopf GF, Amir S, Hartvigsen K, Hansen LF, Woelkers D, Tsimikas S, Binder CJ, Kipps TJ, Witztum JL. IGHV1-69-Encoded Antibodies Expressed in Chronic Lymphocytic Leukemia React with Malondialdehyde-Acetaldehyde Adduct, an Immunodominant Oxidation-Specific Epitope Plos One. 8. PMID 23840319 DOI: 10.1371/journal.pone.0065203  0.52
2013 Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller YI. MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. Journal of Lipid Research. 54: 1877-83. PMID 23667177 DOI: 10.1194/jlr.M036343  0.52
2013 Lichtman AH, Binder CJ, Tsimikas S, Witztum JL. Adaptive immunity in atherogenesis: new insights and therapeutic approaches. The Journal of Clinical Investigation. 123: 27-36. PMID 23281407 DOI: 10.1172/JCI63108  0.52
2013 Yigitkanli K, Pekcec A, Karatas H, Pallast S, Mandeville E, Joshi N, Smirnova N, Gazaryan I, Ratan RR, Witztum JL, Montaner J, Holman TR, Lo EH, van Leyen K. Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Annals of Neurology. 73: 129-35. PMID 23192915 DOI: 10.1002/ana.23734  0.52
2013 Yoshida H, Shoda T, Yanai H, Ikewaki K, Kurata H, Ito K, Furutani N, Tada N, Witztum JL, Tsimikas S. Effects of pitavastatin and atorvastatin on lipoprotein oxidation biomarkers in patients with dyslipidemia. Atherosclerosis. 226: 161-4. PMID 23174369 DOI: 10.1016/j.atherosclerosis.2012.10.069  0.52
2012 Tsimikas S, Willeit P, Willeit J, Santer P, Mayr M, Xu Q, Mayr A, Witztum JL, Kiechl S. Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events Journal of the American College of Cardiology. 60: 2218-2229. PMID 23122790 DOI: 10.1016/j.jacc.2012.08.979  0.52
2012 Holleboom AG, Daniil G, Fu X, Zhang R, Hovingh GK, Schimmel AW, Kastelein JJ, Stroes ES, Witztum JL, Hutten BA, Tsimikas S, Hazen SL, Chroni A, Kuivenhoven JA. Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 3066-75. PMID 23023370 DOI: 10.1161/ATVBAHA.112.255711  0.52
2012 van Dijk RA, Kolodgie F, Ravandi A, Leibundgut G, Hu PP, Prasad A, Mahmud E, Dennis E, Curtiss LK, Witztum JL, Wasserman BA, Otsuka F, Virmani R, Tsimikas S. Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions. Journal of Lipid Research. 53: 2773-90. PMID 22969153 DOI: 10.1194/jlr.P030890  0.52
2012 Turner WW, Hartvigsen K, Boullier A, Montano EN, Witztum JL, VanNieuwenhze MS. Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. Journal of Medicinal Chemistry. 55: 8178-82. PMID 22934615 DOI: 10.1021/jm300685s  0.52
2012 Amir S, Hartvigsen K, Gonen A, Leibundgut G, Que X, Jensen-Jarolim E, Wagner O, Tsimikas S, Witztum JL, Binder CJ. Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease Journal of Lipid Research. 53: 1316-1326. PMID 22508944 DOI: 10.1194/jlr.M025445  0.52
2012 Barish GD, Yu RT, Karunasiri MS, Becerra D, Kim J, Tseng TW, Tai LJ, Leblanc M, Diehl C, Cerchietti L, Miller YI, Witztum JL, Melnick AM, Dent AL, Tangirala RK, et al. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metabolism. 15: 554-62. PMID 22465074 DOI: 10.1016/j.cmet.2012.02.012  0.52
2012 Briley-Saebo KC, Nguyen TH, Saeboe AM, Cho YS, Ryu SK, Volkova ER, Volkava E, Dickson S, Leibundgut G, Wiesner P, Weisner P, Green S, Casanada F, Miller YI, Shaw W, ... Witztum JL, et al. In vivo detection of oxidation-specific epitopes in atherosclerotic lesions using biocompatible manganese molecular magnetic imaging probes. Journal of the American College of Cardiology. 59: 616-26. PMID 22300697 DOI: 10.1016/j.jacc.2011.10.881  0.52
2012 Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum JL, Tsimikas S, Bender TP, et al. B-cell aortic homing and atheroprotection depend on Id3. Circulation Research. 110: e1-12. PMID 22034493 DOI: 10.1161/CIRCRESAHA.111.256438  0.52
2011 Fang L, Green SR, Baek JS, Lee SH, Ellett F, Deer E, Lieschke GJ, Witztum JL, Tsimikas S, Miller YI. In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish. The Journal of Clinical Investigation. 121: 4861-9. PMID 22105168 DOI: 10.1172/JCI57755  0.52
2011 Binder CJ, Witztum JL. Is atherosclerosis an allergic disease? Circulation Research. 109: 1103-4. PMID 22034478 DOI: 10.1161/RES.0b013e31823a8c44  0.52
2011 Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, ... ... Witztum JL, et al. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. Journal of the American College of Cardiology. 58: 1715-27. PMID 21982317 DOI: 10.1016/j.jacc.2011.07.017  0.52
2011 Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 478: 76-81. PMID 21979047 DOI: 10.1038/nature10449  0.52
2011 McMahon M, Skaggs BJ, Sahakian L, Grossman J, FitzGerald J, Ragavendra N, Charles-Schoeman C, Chernishof M, Gorn A, Witztum JL, Wong WK, Weisman M, Wallace DJ, La Cava A, Hahn BH. High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Annals of the Rheumatic Diseases. 70: 1619-24. PMID 21670088 DOI: 10.1136/ard.2010.142737  0.52
2011 Haider L, Fischer MT, Frischer JM, Bauer J, Höftberger R, Botond G, Esterbauer H, Binder CJ, Witztum JL, Lassmann H. Oxidative damage in multiple sclerosis lesions. Brain : a Journal of Neurology. 134: 1914-24. PMID 21653539 DOI: 10.1093/brain/awr128  0.52
2011 Diehl CJ, Barish GD, Downes M, Chou MY, Heinz S, Glass CK, Evans RM, Witztum JL. Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells. Molecular Endocrinology (Baltimore, Md.). 25: 529-45. PMID 21273443 DOI: 10.1210/me.2010-0384  0.52
2011 Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circulation Research. 108: 235-48. PMID 21252151 DOI: 10.1161/CIRCRESAHA.110.223875  0.52
2011 Mendez-Fernandez YV, Stevenson BG, Diehl CJ, Braun NA, Wade NS, Covarrubias R, van Leuven S, Witztum JL, Major AS. The inhibitory FcγRIIb modulates the inflammatory response and influences atherosclerosis in male apoE(-/-) mice. Atherosclerosis. 214: 73-80. PMID 21084088 DOI: 10.1016/j.atherosclerosis.2010.10.018  0.52
2011 Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum JL, Reardon CA, Getz GS. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 290-300. PMID 20876212 DOI: 10.1096/fj.10-165670  0.52
2010 Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum JL, Esko JD, Moulton KS. Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. Plos One. 5: e13919. PMID 21085708 DOI: 10.1371/journal.pone.0013919  0.52
2010 Steinberg D, Witztum JL. Oxidized low-density lipoprotein and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2311-6. PMID 21084697 DOI: 10.1161/ATVBAHA.108.179697  0.52
2010 Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum JL, Tsimikas S, Golenbock D, Moore KJ, Tabas I. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metabolism. 12: 467-82. PMID 21035758 DOI: 10.1016/j.cmet.2010.09.010  0.52
2010 Tsimikas S, Mallat Z, Talmud PJ, Kastelein JJ, Wareham NJ, Sandhu MS, Miller ER, Benessiano J, Tedgui A, Witztum JL, Khaw KT, Boekholdt SM. Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary events. Journal of the American College of Cardiology. 56: 946-55. PMID 20828647 DOI: 10.1016/j.jacc.2010.04.048  0.52
2010 Faghihnia N, Tsimikas S, Miller ER, Witztum JL, Krauss RM. Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet. Journal of Lipid Research. 51: 3324-30. PMID 20713651 DOI: 10.1194/jlr.M005769  0.52
2010 Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. The Journal of Biological Chemistry. 285: 32343-51. PMID 20710028 DOI: 10.1074/jbc.M110.137257  0.52
2010 Sun J, Hartvigsen K, Chou MY, Zhang Y, Sukhova GK, Zhang J, Lopez-Ilasaca M, Diehl CJ, Yakov N, Harats D, George J, Witztum JL, Libby P, Ploegh H, Shi GP. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation. 122: 808-20. PMID 20697023 DOI: 10.1161/CIRCULATIONAHA.109.891887  0.52
2010 Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circulation Research. 107: 56-65. PMID 20489162 DOI: 10.1161/CIRCRESAHA.110.218420  0.52
2010 Yvan-Charvet L, Pagler TA, Seimon TA, Thorp E, Welch CL, Witztum JL, Tabas I, Tall AR. ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circulation Research. 106: 1861-9. PMID 20431058 DOI: 10.1161/CIRCRESAHA.110.217281  0.52
2010 Shao B, Pennathur S, Pagani I, Oda MN, Witztum JL, Oram JF, Heinecke JW. Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. The Journal of Biological Chemistry. 285: 18473-84. PMID 20378541 DOI: 10.1074/jbc.M110.118182  0.52
2010 Cardilo-Reis L, Witztum JL, Binder CJ. When monocytes come (too) close to our hearts. Journal of the American College of Cardiology. 55: 1639-41. PMID 20378084 DOI: 10.1016/j.jacc.2009.11.068  0.52
2010 Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum JL, Kane JP, Tsimikas S. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. Atherosclerosis. 209: 498-503. PMID 19880117 DOI: 10.1016/j.atherosclerosis.2009.09.077  0.52
2010 Kelly JA, Griffin ME, Fava RA, Wood SG, Bessette KA, Miller ER, Huber SA, Binder CJ, Witztum JL, Morganelli PM. Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10. Cardiovascular Research. 85: 224-31. PMID 19720605 DOI: 10.1093/cvr/cvp300  0.52
2009 Durand CA, Hartvigsen K, Fogelstrand L, Kim S, Iritani S, Vanhaesebroeck B, Witztum JL, Puri KD, Gold MR. Phosphoinositide 3-kinase p110δ regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses Journal of Immunology. 183: 5673-5684. PMID 19843950 DOI: 10.4049/jimmunol.0900432  0.52
2009 Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A. Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 114: 5225-35. PMID 19828701 DOI: 10.1182/blood-2009-05-220400  0.52
2009 Stanford KI, Bishop JR, Foley EM, Gonzales JC, Niesman IR, Witztum JL, Esko JD. Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. The Journal of Clinical Investigation. 119: 3236-45. PMID 19805913 DOI: 10.1172/JCI38251  0.52
2009 Crowe CR, Chen K, Pociask DA, Alcorn JF, Krivich C, Enelow RI, Ross TM, Witztum JL, Kolls JK. Critical role of IL-17RA in immunopathology of influenza infection. Journal of Immunology (Baltimore, Md. : 1950). 183: 5301-10. PMID 19783685 DOI: 10.4049/jimmunol.0900995  0.52
2009 Steinberg D, Witztum JL. Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels. Proceedings of the National Academy of Sciences of the United States of America. 106: 9546-7. PMID 19506257 DOI: 10.1073/pnas.0904560106  0.52
2009 Fraley AE, Schwartz GG, Olsson AG, Kinlay S, Szarek M, Rifai N, Libby P, Ganz P, Witztum JL, Tsimikas S. Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial. Journal of the American College of Cardiology. 53: 2186-96. PMID 19497447 DOI: 10.1016/j.jacc.2009.02.041  0.52
2009 Choi SH, Harkewicz R, Lee JH, Boullier A, Almazan F, Li AC, Witztum JL, Bae YS, Miller YI. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake Circulation Research. 104: 1355-1363. PMID 19461045 DOI: 10.1161/CIRCRESAHA.108.192880  0.52
2009 Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans Journal of Clinical Investigation. 119: 1335-1349. PMID 19363291 DOI: 10.1172/JCI36800  0.52
2009 Dennis EA, Witztum JL. Fifty years of research on lipids. Journal of Lipid Research. 50: S1. PMID 19346336 DOI: 10.1194/jlr.SUPPEDITORIAL-50/4-JLR  0.52
2009 Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller YI. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circulation Research. 104: 952-60. PMID 19265037 DOI: 10.1161/CIRCRESAHA.108.189803  0.52
2009 Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. The role of innate immunity in atherogenesis Journal of Lipid Research. 50. PMID 19106070 DOI: 10.1194/jlr.R800100-JLR200  0.52
2009 Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circulation Research. 104: 210-8, 21p following. PMID 19096031 DOI: 10.1161/CIRCRESAHA.108.181040  0.52
2008 Steinberg D, Glass CK, Witztum JL. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation. 118: 672-7. PMID 18678783 DOI: 10.1161/CIRCULATIONAHA.107.753152  0.52
2008 Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. The Journal of Clinical Investigation. 118: 2917-28. PMID 18636118 DOI: 10.1172/JCI34189  0.52
2008 Bergmark C, Dewan A, Orsoni A, Merki E, Miller ER, Shin MJ, Binder CJ, Hörkkö S, Krauss RM, Chapman MJ, Witztum JL, Tsimikas S. A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. Journal of Lipid Research. 49: 2230-9. PMID 18594118 DOI: 10.1194/jlr.M800174-JLR200  0.52
2008 Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum JL, Fuster V, Tsimikas S, Fayad ZA. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 117: 3206-15. PMID 18541740 DOI: 10.1161/CIRCULATIONAHA.107.757120  0.36
2008 Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum JL, FitzGerald GA, Rader DJ. The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. Journal of the American College of Cardiology. 51: 1653-62. PMID 18436117 DOI: 10.1016/j.jacc.2008.01.026  0.52
2008 Chou MY, Hartvigsen K, Hansen LF, Fogelstrand L, Shaw PX, Boullier A, Binder CJ, Witztum JL. Oxidation-specific epitopes are important targets of innate immunity Journal of Internal Medicine. 263: 479-488. PMID 18410591 DOI: 10.1111/j.1365-2796.2008.01968.x  0.52
2008 Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum JL. Natural antibodies in murine atherosclerosis Current Drug Targets. 9: 190-195. PMID 18336236 DOI: 10.2174/138945008783755520  0.52
2008 Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. The Journal of Biological Chemistry. 283: 10241-51. PMID 18263582 DOI: 10.1074/jbc.M709006200  0.52
2007 Binder CJ, Hartvigsen K, Witztum JL. Promise of Immune Modulation to Inhibit Atherogenesis**Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology Journal of the American College of Cardiology. 50: 547-550. PMID 17678739 DOI: 10.1016/j.jacc.2007.04.054  0.52
2007 Bro S, Binder CJ, Witztum JL, Olgaard K, Nielsen LB. Inhibition of the renin-angiotensin system abolishes the proatherogenic effect of uremia in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1080-6. PMID 17347482 DOI: 10.1161/ATVBAHA.107.139634  0.52
2007 Hartvigsen K, Binder CJ, Hansen LF, Rafia A, Juliano J, Hörkkö S, Steinberg D, Palinski W, Witztum JL, Li AC. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 878-885. PMID 17255537 DOI: 10.1161/01.ATV.0000258790.35810.02  0.52
2005 Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum JL. The role of natural antibodies in atherogenesis. Journal of Lipid Research. 46: 1353-63. PMID 15897601 DOI: 10.1194/jlr.R500005-JLR200  0.52
2005 Buono C, Binder CJ, Stavrakis G, Witztum JL, Glimcher LH, Lichtman AH. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America. 102: 1596-601. PMID 15665085 DOI: 10.1073/pnas.0409015102  0.52
2004 Chang MK, Binder CJ, Miller YI, Subbanagounder G, Silverman GJ, Berliner JA, Witztum JL. Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. The Journal of Experimental Medicine. 200: 1359-70. PMID 15583011 DOI: 10.1084/jem.20031763  0.52
2004 Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL, Palinski W, Glass CK. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. The Journal of Clinical Investigation. 114: 1564-76. PMID 15578089 DOI: 10.1172/JCI18730  0.52
2004 Binder CJ, Hartvigsen K, Chang MK, Miller M, Broide D, Palinski W, Curtiss LK, Corr M, Witztum JL. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. The Journal of Clinical Investigation. 114: 427-37. PMID 15286809 DOI: 10.1172/JCI20479  0.52
2004 Reardon CA, Miller ER, Blachowicz L, Lukens J, Binder CJ, Witztum JL, Getz GS. Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice. Journal of Lipid Research. 45: 1347-54. PMID 15102879 DOI: 10.1194/jlr.M400075-JLR200  0.52
2003 Miller YI, Chang MK, Binder CJ, Shaw PX, Witztum JL. Oxidized low density lipoprotein and innate immune receptors. Current Opinion in Lipidology. 14: 437-45. PMID 14501582 DOI: 10.1097/01.mol.0000092631.86399.49  0.52
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