Victor Velculescu - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Genetics, Oncology, Molecular Biology

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 van 't Erve I, Wesdorp NJ, Medina JE, Ferreira L, Leal A, Huiskens J, Bolhuis K, van Waesberghe JTM, Swijnenburg RJ, van den Broek D, Velculescu VE, Kazemier G, Punt CJA, Meijer GA, Fijneman RJA. A146 Mutations Are Associated With Distinct Clinical Behavior in Patients With Colorectal Liver Metastases. Jco Precision Oncology. 5. PMID 34820593 DOI: 10.1200/PO.21.00223  0.36
2021 Forde PM, Anagnostou V, Sun Z, Dahlberg SE, Kindler HL, Niknafs N, Purcell T, Santana-Davila R, Dudek AZ, Borghaei H, Lanis M, Belcaid Z, Smith KN, Balan A, White JR, ... ... Velculescu VE, et al. Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial. Nature Medicine. PMID 34750557 DOI: 10.1038/s41591-021-01541-0  0.361
2021 Mathios D, Johansen JS, Cristiano S, Medina JE, Phallen J, Larsen KR, Bruhm DC, Niknafs N, Ferreira L, Adleff V, Chiao JY, Leal A, Noe M, White JR, Arun AS, ... ... Velculescu VE, et al. Detection and characterization of lung cancer using cell-free DNA fragmentomes. Nature Communications. 12: 5060. PMID 34417454 DOI: 10.1038/s41467-021-24994-w  0.343
2020 Anagnostou V, Bruhm DC, Niknafs N, White JR, Shao XM, Sidhom JW, Stein J, Tsai HL, Wang H, Belcaid Z, Murray J, Balan A, Ferreira L, Ross-Macdonald P, Wind-Rotolo M, ... ... Velculescu VE, et al. Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma. Cell Reports. Medicine. 1: 100139. PMID 33294860 DOI: 10.1016/j.xcrm.2020.100139  0.316
2020 Anagnostou V, Niknafs N, Marrone K, Bruhm DC, White JR, Naidoo J, Hummelink K, Monkhorst K, Lalezari F, Lanis M, Rosner S, Reuss JE, Smith KN, Adleff V, Rodgers K, ... ... Velculescu VE, et al. Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer. Nature Cancer. 1: 99-111. PMID 32984843 DOI: 10.1038/s43018-019-0008-8  0.353
2020 Erve IV', Greuter MJE, Bolhuis K, Vessies DCL, Leal A, Vink GR, van den Broek D, Velculescu VE, Punt CJA, Meijer GA, Coupé VMH, Fijneman RJA. Diagnostic strategies towards clinical implementation of liquid biopsy RAS/BRAF circulating tumor DNA analyses in patients with metastatic colorectal cancer. The Journal of Molecular Diagnostics : Jmd. PMID 32961317 DOI: 10.1016/J.Jmoldx.2020.09.002  0.322
2020 Noë M, Niknafs N, Fischer CG, Hackeng WM, Beleva Guthrie V, Hosoda W, Debeljak M, Papp E, Adleff V, White JR, Luchini C, Pea A, Scarpa A, Butturini G, Zamboni G, ... ... Velculescu VE, et al. Genomic characterization of malignant progression in neoplastic pancreatic cysts. Nature Communications. 11: 4085. PMID 32796935 DOI: 10.1038/S41467-020-17917-8  0.37
2020 Leal A, van Grieken NCT, Palsgrove DN, Phallen J, Medina JE, Hruban C, Broeckaert MAM, Anagnostou V, Adleff V, Bruhm DC, Canzoniero JV, Fiksel J, Nordsmark M, Warmerdam FARM, Verheul HMW, ... ... Velculescu VE, et al. White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer. Nature Communications. 11: 525. PMID 31988276 DOI: 10.1038/S41467-020-14310-3  0.321
2020 Arniella M, Ravi A, Stewart C, Freeman S, Awad M, Forde P, Anagnostou V, Henick B, Riess J, Gibbons D, Pennell N, Velcheti V, Leshchiner I, Kim J, Digumarthy S, ... ... Velculescu V, et al. Abstract 5902: Integrative genomic analysis of checkpoint blockade in lung cancer: A multi-institution SU2C collaborative Cancer Research. 80: 5902-5902. DOI: 10.1158/1538-7445.Am2020-5902  0.37
2019 Georgiadis A, Durham JN, Keefer LA, Bartlett BR, Zielonka M, Murphy D, White JR, Lu S, Verner EL, Ruan F, Riley D, Anders RA, Gedvilaite E, Angiuoli S, Jones S, ... Velculescu VE, et al. Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31506389 DOI: 10.1158/1078-0432.Ccr-19-1372  0.366
2019 Mathios D, Hwang T, Xia Y, Phallen J, Rui Y, See AP, Maxwell R, Belcaid Z, Casaos J, Burger PC, McDonald KL, Gallia GL, Cope L, Kai M, Brem H, ... ... Velculescu VE, et al. Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types. International Journal of Cancer. PMID 31373686 DOI: 10.1002/Ijc.32587  0.34
2019 Cristiano S, Leal A, Phallen J, Fiksel J, Adleff V, Bruhm DC, Jensen SØ, Medina JE, Hruban C, White JR, Palsgrove DN, Niknafs N, Anagnostou V, Forde P, Naidoo J, ... ... Velculescu VE, et al. Genome-wide cell-free DNA fragmentation in patients with cancer. Nature. PMID 31142840 DOI: 10.1038/S41586-019-1272-6  0.363
2019 Leal A, Cristiano S, Phallen J, Fiksel J, Adleff V, Bruhm DC, Jensen SØ, Medina JE, Palsgrove DN, Niknafs N, Anagnostou V, Forde PM, Brahmer JR, Fijneman R, Johansen JS, ... ... Velculescu VE, et al. Genome-wide cell-free DNA fragmentation profiling for early cancer detection. Journal of Clinical Oncology. 37: 3018-3018. DOI: 10.1200/Jco.2019.37.15_Suppl.3018  0.307
2019 Kinose Y, Hallberg D, Mills G, Ince T, Velculescu V, Simpkins F, Drapkin R. Abstract GMM-036: COMPREHENSIVE GENOMIC, PROTEOMIC, AND EXPERIMENTAL CHARACTERIZATION OF OVARIAN CLEAR CELL CARCINOMA CELL LINES FOR IMPROVED DRUG DEVELOPMENT Clinical Cancer Research. 25. DOI: 10.1158/1557-3265.Ovcasymp18-Gmm-036  0.385
2019 Caushi JX, Ji Z, Zhang J, Asmar ME, Anagnostou V, Cottrell TR, Chan HY, Guo H, Merghoub T, Wolchok JD, Naidoo J, Marrone KA, Chaft JE, Hellmann MD, Gabrielson E, ... ... Velculescu VE, et al. Abstract 4041: Coupling neoantigen specific T cell clonotypes and their molecular phenotypes at the single cell level in resectable anti-PD-1 treated NSCLC Cancer Research. 79: 4041-4041. DOI: 10.1158/1538-7445.Am2019-4041  0.333
2019 Kinose Y, Hallberg D, Doberstein K, Mills G, Ince T, Velculescu V, Simpkins F, Drapkin R. Abstract 1065: Comprehensive molecular and experimental characterization of ovarian clear cell carcinoma cell lines forin vivodrug development Cancer Research. 79: 1065-1065. DOI: 10.1158/1538-7445.Am2019-1065  0.363
2018 Phallen J, Leal A, Woodward BD, Forde PM, Naidoo J, Marrone KA, Brahmer JR, Fiksel J, Medina JE, Cristiano S, Palsgrove DN, Gocke CD, Bruhm DC, Keshavarzian P, Adleff V, ... ... Velculescu VE, et al. Early Noninvasive Detection of Response to Targeted Therapy in Non-Small Cell Lung Cancer. Cancer Research. PMID 30573519 DOI: 10.1158/0008-5472.CAN-18-1082  0.33
2018 Papp E, Hallberg D, Konecny GE, Bruhm DC, Adleff V, Noë M, Kagiampakis I, Palsgrove D, Conklin D, Kinose Y, White JR, Press MF, Drapkin R, Easwaran H, Baylin SB, ... ... Velculescu VE, et al. Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines. Cell Reports. 25: 2617-2633. PMID 30485824 DOI: 10.1016/J.Celrep.2018.10.096  0.378
2018 Wood DE, White JR, Georgiadis A, Van Emburgh B, Parpart-Li S, Mitchell J, Anagnostou V, Niknafs N, Karchin R, Papp E, McCord C, LoVerso P, Riley D, Diaz LA, Jones S, ... ... Velculescu VE, et al. A machine learning approach for somatic mutation discovery. Science Translational Medicine. 10. PMID 30185652 DOI: 10.1126/Scitranslmed.Aar7939  0.44
2018 Forde PM, Chaft JE, Smith KN, Anagnostou V, Cottrell TR, Hellmann MD, Zahurak M, Yang SC, Jones DR, Broderick S, Battafarano RJ, Velez MJ, Rekhtman N, Olah Z, Naidoo J, ... ... Velculescu VE, et al. Neoadjuvant PD-1 Blockade in Resectable Lung Cancer. The New England Journal of Medicine. PMID 29658848 DOI: 10.1056/Nejmoa1716078  0.332
2018 Forde PM, Chaft JE, Smith KN, Anagnostou V, Cottrell TR, Hellmann MD, Zahurak M, Yang SC, Jones DR, Broderick S, Battafarano RJ, Velez MJ, Rekhtman N, Olah Z, Naidoo J, ... ... Velculescu VE, et al. Abstract CT079: Neoadjuvant PD-1 blockade in resectable lung cancer Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Ct079  0.319
2018 Anagnostou V, Forde P, Naidoo J, Marrone K, Adleff V, White J, Phallen J, Leal A, Hruban C, Sivakumar A, Verde F, Karchin R, Brahmer J, Velculescu V. Abstract 3668: ctDNA and TCR dynamics predict response toimmune checkpoint blockade in non-small cell lung cancer Cancer Research. 78: 3668-3668. DOI: 10.1158/1538-7445.Am2018-3668  0.372
2018 Wood D, White J, Georgiadis A, Emburgh BV, Parpart-Li S, Mitchell J, Anagnostou V, Niknafs N, Karchin R, Papp E, McCord C, Loverso P, Riley D, Diaz LA, Jones S, ... ... Velculescu VE, et al. Abstract 3271: A machine learning approach for somatic mutation discovery Cancer Research. 78: 3271-3271. DOI: 10.1158/1538-7445.Am2018-3271  0.422
2018 Nesselbush M, Jones S, Keefer L, Sengamalay N, Velculescu V, Diaz L, Sausen M, Angiuoli S. Abstract A027: Analytic validation of a pan-cancer tumor mutational burden assay Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-A027  0.425
2017 Labidi-Galy SI, Papp E, Hallberg D, Niknafs N, Adleff V, Noe M, Bhattacharya R, Novak M, Jones S, Phallen J, Hruban CA, Hirsch MS, Lin DI, Schwartz L, Maire CL, ... ... Velculescu VE, et al. High grade serous ovarian carcinomas originate in the fallopian tube. Nature Communications. 8: 1093. PMID 29061967 DOI: 10.1038/S41467-017-00962-1  0.361
2017 Phallen J, Sausen M, Adleff V, Leal A, Hruban C, White J, Anagnostou V, Fiksel J, Cristiano S, Papp E, Speir S, Reinert T, Orntoft MW, Woodward BD, Murphy D, ... ... Velculescu VE, et al. Direct detection of early-stage cancers using circulating tumor DNA. Science Translational Medicine. 9. PMID 28814544 DOI: 10.1126/Scitranslmed.Aan2415  0.451
2017 Barrett MT, Deiotte R, Lenkiewicz E, Malasi S, Holley T, Evers L, Posner RG, Jones T, Han H, Sausen M, Velculescu VE, Drebin J, O'Dwyer P, Jameson G, Ramanathan RK, et al. Clinical study of genomic drivers in pancreatic ductal adenocarcinoma. British Journal of Cancer. PMID 28720843 DOI: 10.1038/Bjc.2017.209  0.336
2017 Spira A, Yurgelun MB, Alexandrov L, Rao A, Bejar R, Polyak K, Giannakis M, Shilatifard A, Finn OJ, Dhodapkar M, Kay NE, Braggio E, Vilar E, Mazzilli SA, Rebbeck TR, ... ... Velculescu VE, et al. Precancer Atlas to Drive Precision Prevention Trials. Cancer Research. 77: 1510-1541. PMID 28373404 DOI: 10.1158/0008-5472.Can-16-2346  0.351
2017 Yeung KT, More S, Woodward B, Velculescu V, Husain H. Circulating Tumor DNA for Mutation Detection and Identification of Mechanisms of Resistance in Non-Small Cell Lung Cancer. Molecular Diagnosis & Therapy. PMID 28337711 DOI: 10.1007/S40291-017-0260-5  0.363
2017 Novak M, Angiuoli S, Diaz LA, Georgiadis A, Jones S, Loverso PR, Parpart-Li S, Sevdali M, Velculescu VE, Verner EL, White J, Zhang T, Sausen M. Abstract 604: Accurate identification and prioritization of candidate neoantigens from integrated cancer exome and transcriptome sequencing of FFPE samples Cancer Research. 77: 604-604. DOI: 10.1158/1538-7445.Am2017-604  0.349
2016 Anagnostou V, Smith KN, Forde PM, Niknafs N, Bhattacharya R, White J, Zhang T, Adleff V, Phallen J, Wali N, Hruban C, Guthrie VB, Rodgers K, Naidoo J, Kang H, ... ... Velculescu VE, et al. Evolution of Neoantigen Landscape During Immune Checkpoint Blockade in Non-Small Cell Lung Cancer. Cancer Discovery. PMID 28031159 DOI: 10.1158/2159-8290.Cd-16-0828  0.34
2016 Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, ... ... Velculescu VE, et al. Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. Nature Communications. 7: 11971. PMID 27321283 DOI: 10.1038/Ncomms11971  0.334
2016 Hamm CA, Moran D, Rao K, Trusk PB, Pry K, Sausen M, Jones S, Velculescu VE, Cristofanilli M, Bacus S. Genomic and immunological tumor profiling identifies targetable pathways and extensive CD8+/PDL1+ immune infiltration in inflammatory breast cancer tumors. Molecular Cancer Therapeutics. PMID 27196778 DOI: 10.1158/1535-7163.MCT-15-0353  0.371
2016 White J, Simmons J, Angiuoli S, Sausen M, Jones S, Kann L, Shukla M, Sevdali M, Velculescu V, Diaz L, Zhang T. Abstract A039: Accurate identification and prioritization of candidate neoantigens from cancer exome sequencing Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A039  0.387
2016 White J, Angiuoli S, Sausen M, Jones S, Kann L, Shukla M, Sevdali M, Velculescu V, Diaz L, Zhang T. Abstract 528: Identify and prioritize candidate neoantigens from cancer exome sequencing with unmatched accuracy Cancer Research. 76: 528-528. DOI: 10.1158/1538-7445.Am2016-528  0.39
2016 Parpart-Li ST, Bartlett B, Popoli M, Adleff V, Brahmer J, Azad N, Bonerigo S, Browner I, Ryan A, Velculescu V, Sausen M, Diaz LA. Abstract 3957: Optimized plasma collection procedures for liquid biopsy analyses in cancer Cancer Research. 76: 3957-3957. DOI: 10.1158/1538-7445.Am2016-3957  0.341
2016 Vaz MP, Hwang SY, Patil A, Phallen J, Murphy L, Zahnow CA, Velculescu VE, Easwaran H, Baylin SB. Abstract 2773: Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to transformation Cancer Research. 76: 2773-2773. DOI: 10.1158/1538-7445.Am2016-2773  0.323
2015 Bertotti A, Papp E, Jones S, Adleff V, Anagnostou V, Lupo B, Sausen M, Phallen J, Hruban CA, Tokheim C, Niknafs N, Nesselbush M, Lytle K, Sassi F, Cottino F, ... ... Velculescu VE, et al. The genomic landscape of response to EGFR blockade in colorectal cancer. Nature. PMID 26416732 DOI: 10.1038/Nature14969  0.38
2015 Elias KM, Emori MM, Papp E, MacDuffie E, Konecny GE, Velculescu VE, Drapkin R. Beyond genomics: Critical evaluation of cell line utility for ovarian cancer research. Gynecologic Oncology. 139: 97-103. PMID 26321251 DOI: 10.1016/J.Ygyno.2015.08.017  0.338
2015 Sausen M, Phallen J, Adleff V, Jones S, Leary RJ, Barrett MT, Anagnostou V, Parpart-Li S, Murphy D, Kay Li Q, Hruban CA, Scharpf R, White JR, O'Dwyer PJ, Allen PJ, ... ... Velculescu VE, et al. Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients. Nature Communications. 6: 7686. PMID 26154128 DOI: 10.1038/Ncomms8686  0.754
2015 Jones S, Anagnostou V, Lytle K, Parpart-Li S, Nesselbush M, Riley DR, Shukla M, Chesnick B, Kadan M, Papp E, Galens KG, Murphy D, Zhang T, Kann L, Sausen M, ... ... Velculescu VE, et al. Personalized genomic analyses for cancer mutation discovery and interpretation. Science Translational Medicine. 7: 283ra53. PMID 25877891 DOI: 10.1200/Jco.2015.33.15_Suppl.1529  0.449
2015 Izumchenko E, Sun K, Jones S, Brait M, Agrawal N, Koch W, McCord CL, Riley DR, Angiuoli SV, Velculescu VE, Jiang WW, Sidransky D. Notch1 mutations are drivers of oral tumorigenesis. Cancer Prevention Research (Philadelphia, Pa.). 8: 277-86. PMID 25406187 DOI: 10.1158/1940-6207.CAPR-14-0257  0.321
2015 Wang JS, Sausen M, Parpart-Li S, Murphy DM, Velculescu VE, Wood LD, Solt-Linville S, Sugar E, Bartlett B, Blair C, Dauses T, Jaffee EM, Hruban RH, Laheru D, Diaz LA. Circulating tumor DNA (ctDNA) as a prognostic marker for recurrence in resected pancreas cancer. Journal of Clinical Oncology. 33: 11025-11025. DOI: 10.1200/Jco.2015.33.15_Suppl.11025  0.388
2015 Sausen M, Phallen J, Adleff V, Jones S, Leary RJ, Lytle K, Parpart-Li S, Murphy D, Barrett MT, Linehan DC, Maitra A, Hruban R, Hoff DDV, Johansen JS, Diaz LA, ... ... Velculescu VE, et al. Abstract 619: Identification of clinically actionable genomic alterations in the tumor and circulation of pancreatic cancer patients Cancer Research. 75: 619-619. DOI: 10.1158/1538-7445.Am2015-619  0.799
2015 Jones S, Sausen M, Anagnostou V, Angiuoli SV, Chesnick B, Galens K, Kadan M, Kann L, Lytle K, Murphy D, Nesselbush M, Papp E, Parpart-Li S, Riley D, Shukla M, ... ... Velculescu VE, et al. Abstract 3894: The importance of matched tumor and normal DNA for somatic mutation discovery and clinical interpretation Cancer Research. 75: 3894-3894. DOI: 10.1158/1538-7445.Am2015-3894  0.428
2014 Jones S, Stransky N, McCord CL, Cerami E, Lagowski J, Kelly D, Angiuoli SV, Sausen M, Kann L, Shukla M, Makar R, Wood LD, Diaz LA, Lengauer C, Velculescu VE. Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes. Nature Communications. 5: 5006. PMID 25233892 DOI: 10.1038/ncomms6006  0.304
2014 Haber DA, Velculescu VE. Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA. Cancer Discovery. 4: 650-61. PMID 24801577 DOI: 10.1158/2159-8290.Cd-13-1014  0.359
2014 Guerrero-Preston R, Michailidi C, Marchionni L, Pickering CR, Frederick MJ, Myers JN, Yegnasubramanian S, Hadar T, Noordhuis MG, Zizkova V, Fertig E, Agrawal N, Westra W, Koch W, Califano J, ... Velculescu VE, et al. Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer. Epigenetics : Official Journal of the Dna Methylation Society. 9: 1031-46. PMID 24786473 DOI: 10.4161/Epi.29025  0.367
2014 Garralda E, Paz K, López-Casas PP, Jones S, Katz A, Kann LM, López-Rios F, Sarno F, Al-Shahrour F, Vasquez D, Bruckheimer E, Angiuoli SV, Calles A, Diaz LA, Velculescu VE, et al. Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 2476-84. PMID 24634382 DOI: 10.1158/1078-0432.Ccr-13-3047  0.335
2014 Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, Antonarakis ES, Azad NS, Bardelli A, Brem H, Cameron JL, ... ... Velculescu VE, et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Science Translational Medicine. 6: 224ra24. PMID 24553385 DOI: 10.1126/Scitranslmed.3007094  0.787
2014 Guerrero-Preston R, Michailidi C, Marchionni L, Pickering C, Frederick M, Myers J, Yegnasubramanian S, Hadar T, Noordhuis M, Fertig E, Agrawal N, Westra W, Koch W, Califano J, Velculescu V, et al. Abstract 2482: Key tumor suppressor genes inactivated by promoter methylation and somatic mutations in head and neck cancer Cancer Research. 74: 2482-2482. DOI: 10.1158/1538-7445.Am2014-2482  0.419
2013 Jiao Y, Pawlik TM, Anders RA, Selaru FM, Streppel MM, Lucas DJ, Niknafs N, Guthrie VB, Maitra A, Argani P, Offerhaus GJ, Roa JC, Roberts LR, Gores GJ, Popescu I, ... ... Velculescu VE, et al. Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nature Genetics. 45: 1470-3. PMID 24185509 DOI: 10.1038/Ng.2813  0.303
2013 Leary RJ, Sausen M, Diaz LA, Velculescu VE. Cancer detection using whole-genome sequencing of cell free DNA. Oncotarget. 4: 1119-20. PMID 23912395 DOI: 10.18632/Oncotarget.1183  0.796
2013 Bardelli A, Corso S, Bertotti A, Hobor S, Valtorta E, Siravegna G, Sartore-Bianchi A, Scala E, Cassingena A, Zecchin D, Apicella M, Migliardi G, Galimi F, Lauricella C, Zanon C, ... ... Velculescu VE, et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discovery. 3: 658-73. PMID 23729478 DOI: 10.1158/2159-8290.CD-12-0558  0.359
2013 Ihnen M, zu Eulenburg C, Kolarova T, Qi JW, Manivong K, Chalukya M, Dering J, Anderson L, Ginther C, Meuter A, Winterhoff B, Jones S, Velculescu VE, Venkatesan N, Rong HM, et al. Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer. Molecular Cancer Therapeutics. 12: 1002-15. PMID 23729402 DOI: 10.1158/1535-7163.Mct-12-0813  0.384
2013 Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA, Kinzler KW. Cancer genome landscapes. Science (New York, N.Y.). 339: 1546-58. PMID 23539594 DOI: 10.1126/Science.1235122  0.443
2013 Agrawal N, Jiao Y, Sausen M, Leary R, Bettegowda C, Roberts NJ, Bhan S, Ho AS, Khan Z, Bishop J, Westra WH, Wood LD, Hruban RH, Tufano RP, Robinson B, ... ... Velculescu VE, et al. Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS. The Journal of Clinical Endocrinology and Metabolism. 98: E364-9. PMID 23264394 DOI: 10.1210/Jc.2012-2703  0.773
2013 Sausen M, Leary RJ, Jones S, Wu J, Reynolds CP, Liu X, Blackford A, Parmigiani G, Diaz LA, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE, Hogarty MD. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nature Genetics. 45: 12-7. PMID 23202128 DOI: 10.1038/Ng.2493  0.763
2013 Barrett MT, Lenkiewicz E, Lisa E, Perez-Mancera P, Tuveson D, Aust D, Pilarsky C, Aziz M, Posner R, Ramanathan R, Velculescu V, Kramer A, Drebin J, Hoff DDV. Abstract 798: Clonal analysis and clinical translation of pancreatic adenocarcinoma genomes. Cancer Research. 73: 798-798. DOI: 10.1158/1538-7445.Am2013-798  0.403
2013 Garralda E, Paz K, López-Casas PP, Jones S, Katz A, Kann LM, López-Rios F, Sarno F, Al-Shahrour F, Vasquez D, Bruckheimer E, Angiuoli SV, Diaz LA, Valencia A, Velculescu VE, et al. Abstract 2205: Integrated next generation sequencing and patient-derived xenografts to personalized cancer treatment. Cancer Research. 73: 2205-2205. DOI: 10.1158/1538-7445.Am2013-2205  0.327
2012 Leary RJ, Sausen M, Kinde I, Papadopoulos N, Carpten JD, Craig D, O'Shaughnessy J, Kinzler KW, Parmigiani G, Vogelstein B, Diaz LA, Velculescu VE. Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Science Translational Medicine. 4: 162ra154. PMID 23197571 DOI: 10.1126/Scitranslmed.3004742  0.788
2012 Yachida S, White CM, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM, Morgan RA, Saunders T, Laheru DA, Herman JM, Hruban RH, Klein AP, Jones S, Velculescu V, Wolfgang CL, et al. Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 6339-47. PMID 22991414 DOI: 10.1158/1078-0432.Ccr-12-1215  0.321
2012 Kim MS, Kuppireddy SV, Sakamuri S, Singal M, Getnet D, Harsha HC, Goel R, Balakrishnan L, Jacob HK, Kashyap MK, Tankala SG, Maitra A, Iacobuzio-Donahue CA, Jaffee E, Goggins MG, ... Velculescu VE, et al. Rapid characterization of candidate biomarkers for pancreatic cancer using cell microarrays (CMAs). Journal of Proteome Research. 11: 5556-63. PMID 22985314 DOI: 10.1021/Pr300483R  0.315
2012 Iacobuzio-Donahue CA, Velculescu VE, Wolfgang CL, Hruban RH. Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 4257-65. PMID 22896692 DOI: 10.1158/1078-0432.CCR-12-0315  0.379
2012 Agrawal N, Jiao Y, Bettegowda C, Hutfless SM, Wang Y, David S, Cheng Y, Twaddell WS, Latt NL, Shin EJ, Wang LD, Wang L, Yang W, Velculescu VE, Vogelstein B, et al. Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discovery. 2: 899-905. PMID 22877736 DOI: 10.1158/2159-8290.Cd-12-0189  0.351
2012 Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy ML, Gallinger S, Schwartz AG, Syngal S, Cote ML, Axilbund J, Schulick R, Ali SZ, Eshleman JR, Velculescu VE, et al. ATM mutations in patients with hereditary pancreatic cancer Cancer Discovery. 2: 41-46. PMID 22585167 DOI: 10.1158/2159-8290.Cd-11-0194  0.396
2012 Willard MD, Lajiness ME, Wulur IH, Feng B, Swearingen ML, Uhlik MT, Kinzler KW, Velculescu VE, Sjöblom T, Markowitz SD, Powell SM, Vogelstein B, Barber TD. Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes. Molecular Cancer Research : McR. 10: 739-49. PMID 22516348 DOI: 10.1158/1541-7786.Mcr-11-0483  0.309
2012 Jones S, Wang TL, Kurman RJ, Nakayama K, Velculescu VE, Vogelstein B, Kinzler KW, Papadopoulos N, Shih IM. Low-grade serous carcinomas of the ovary contain very few point mutations Journal of Pathology. 226: 413-420. PMID 22102435 DOI: 10.1002/Path.3967  0.329
2012 Jones S, Li M, Williams Parsons D, Zhang X, Wesseling J, Kristel P, Schmidt MK, Markowitz S, Yan H, Bigner D, Hruban RH, Eshleman JR, Iacobuzio-Donahue CA, Goggins M, Maitra A, ... ... Velculescu VE, et al. Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types Human Mutation. 33: 100-103. PMID 22009941 DOI: 10.1002/Humu.21633  0.403
2012 Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy M, Gallinger S, Schwartz AG, Syngal S, Cote ML, Axilbund J, Schulick R, Ali SZ, Eshleman JR, Velculescu V, et al. Abstract 2628: Genome-wide sequencing identifiesATMas a pancreatic cancer susceptibility gene Cancer Research. 72: 2628-2628. DOI: 10.1158/1538-7445.Am2012-2628  0.378
2011 Velculescu VE, Diaz LA. Understanding the enemy. Science Translational Medicine. 3: 98ps37. PMID 21885403 DOI: 10.1126/scitranslmed.3003001  0.303
2011 Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH, Rodriguez FJ, Cahill DP, McLendon R, Riggins G, Velculescu VE, Oba-Shinjo SM, Marie SK, Vogelstein B, Bigner D, et al. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science (New York, N.Y.). 333: 1453-5. PMID 21817013 DOI: 10.1126/Science.1210557  0.328
2011 Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Treviño L, ... ... Velculescu VE, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (New York, N.Y.). 333: 1154-7. PMID 21798897 DOI: 10.1126/Science.1206923  0.392
2011 Shih IeM, Panuganti PK, Kuo KT, Mao TL, Kuhn E, Jones S, Velculescu VE, Kurman RJ, Wang TL. Somatic mutations of PPP2R1A in ovarian and uterine carcinomas. The American Journal of Pathology. 178: 1442-7. PMID 21435433 DOI: 10.1016/J.Ajpath.2011.01.009  0.319
2011 Bessarabova M, Pustovalova O, Shi W, Serebriyskaya T, Ishkin A, Polyak K, Velculescu VE, Nikolskaya T, Nikolsky Y. Functional synergies yet distinct modulators affected by genetic alterations in common human cancers. Cancer Research. 71: 3471-81. PMID 21398405 DOI: 10.1158/0008-5472.CAN-10-3038  0.344
2011 Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA, Vogelstein B, Kinzler KW, Hruban RH, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (New York, N.Y.). 331: 1199-203. PMID 21252315 DOI: 10.1126/Science.1200609  0.352
2011 Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, ... ... Velculescu VE, et al. The genetic landscape of the childhood cancer medulloblastoma. Science (New York, N.Y.). 331: 435-9. PMID 21163964 DOI: 10.1126/Science.1198056  0.773
2011 Guerrero-Preston R, Agrawal N, Sidransky D, Li RJ, Westra WH, Koch WM, Califano JA, Vogelstein B, Velculescu VE, Papadopoulos N, Kinzler KW. Abstract PR3: Exome sequencing of head and neck squamous cell carcinoma reveals a higher frequency of mutations in TP53 among African Americans Cancer Epidemiology, Biomarkers & Prevention. 20. DOI: 10.1158/1055-9965.Disp-11-Pr3  0.314
2010 Boca SM, Kinzler KW, Velculescu VE, Vogelstein B, Parmigiani G. Patient-oriented gene set analysis for cancer mutation data Genome Biology. 11. PMID 21092299 DOI: 10.1186/Gb-2010-11-11-R112  0.308
2010 Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA. Distant metastasis occurs late during the genetic evolution of pancreatic cancer Nature. 467: 1114-1117. PMID 20981102 DOI: 10.1038/Nature09515  0.777
2010 Jones S, Wang TL, Shih IeM, Mao TL, Nakayama K, Roden R, Glas R, Slamon D, Diaz LA, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science (New York, N.Y.). 330: 228-31. PMID 20826764 DOI: 10.1126/Science.1196333  0.419
2010 Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, ... ... Velculescu VE, et al. International network of cancer genome projects. Nature. 464: 993-8. PMID 20393554 DOI: 10.1038/Nature08987  0.342
2010 Leary RJ, Kinde I, Diehl F, Schmidt K, Clouser C, Duncan C, Antipova A, Lee C, McKernan K, De La Vega FM, Kinzler KW, Vogelstein B, Diaz LA, Velculescu VE. Development of personalized tumor biomarkers using massively parallel sequencing. Science Translational Medicine. 2: 20ra14. PMID 20371490 DOI: 10.1126/Scitranslmed.3000702  0.787
2010 Zhang X, Li M, Ouillette P, Diaz L, Reis M, Velculescu V, Kinzler K, Malek S, Vogelstein B. Identification of Somatically Acquired Gene Mutations In the Kineome and Exome In CLL Blood. 116: 2410-2410. DOI: 10.1182/Blood.V116.21.2410.2410  0.369
2009 Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science (New York, N.Y.). 325: 1555-9. PMID 19661383 DOI: 10.1126/Science.1174229  0.327
2009 Carter H, Chen S, Isik L, Tyekucheva S, Velculescu VE, Kinzler KW, Vogelstein B, Karchin R. Cancer-specific high-throughput annotation of somatic mutations: Computational prediction of driver missense mutations Cancer Research. 69: 6660-6667. PMID 19654296 DOI: 10.1158/0008-5472.Can-09-1133  0.343
2009 Guda K, Moinova H, He J, Jamison O, Ravi L, Natale L, Lutterbaugh J, Lawrence E, Lewis S, Willson JKV, Lowe JB, Wiesner GL, Parmigiani G, Barnholtz-Sloan J, Dawson DW, ... Velculescu VE, et al. Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers Proceedings of the National Academy of Sciences of the United States of America. 106: 12921-12925. PMID 19617566 DOI: 10.1073/Pnas.0901454106  0.403
2009 Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, ... ... Velculescu VE, et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 4674-9. PMID 19584151 DOI: 10.1158/1078-0432.Ccr-09-0227  0.783
2009 Duncan CG, Leary RJ, Lin JC, Cummins J, Di C, Schaefer CF, Wang TL, Riggins GJ, Edwards J, Bigner D, Kopelovich L, Vogelstein B, Kinzler KW, Velculescu VE, Yan H. Identification of microbial DNA in human cancer. Bmc Medical Genomics. 2: 22. PMID 19426505 DOI: 10.1186/1755-8794-2-22  0.752
2009 Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JCH, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, ... ... Velculescu VE, et al. Genetic mutations associated with Cigarette smoking in pancreatic cancer Cancer Research. 69: 3681-3688. PMID 19351817 DOI: 10.1158/0008-5472.Can-09-0015  0.752
2009 Kuo KT, Mao TL, Jones S, Veras E, Ayhan A, Wang TL, Glas R, Slamon D, Velculescu VE, Kuman RJ, Shih IeM. Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma. The American Journal of Pathology. 174: 1597-601. PMID 19349352 DOI: 10.2353/ajpath.2009.081000  0.411
2009 Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW, Lin JCH, Palmisano E, Brune K, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Parmigiani G, Kern SE, Velculescu VE, et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene Science. 324: 217. PMID 19264984 DOI: 10.1126/Science.1171202  0.371
2009 Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, ... Velculescu VE, et al. IDH1 and IDH2 mutations in gliomas. The New England Journal of Medicine. 360: 765-73. PMID 19228619 DOI: 10.1056/Nejmoa0808710  0.346
2009 Parmigiani G, Boca S, Lin J, Kinzler KW, Velculescu V, Vogelstein B. Design and analysis issues in genome-wide somatic mutation studies of cancer Genomics. 93: 17-21. PMID 18692126 DOI: 10.1016/J.Ygeno.2008.07.005  0.385
2009 Konecny GE, Manivong K, Guorong E, Glas R, Dering J, Anderson L, Ginther C, Velculescu V, Calzone F, Slamon DJ. Abstract B232: Preclinical evaluation of AMG479 a fully human insulin‐like growth factor receptor‐1 (IGFR1) antibody in ovarian cancer cells Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B232  0.327
2008 Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, Parsons DW, Jones S, Sjöblom T, Park BH, Parsons R, Willis J, Dawson D, Willson JK, Nikolskaya T, Nikolsky Y, ... ... Velculescu VE, et al. Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 105: 16224-9. PMID 18852474 DOI: 10.1073/Pnas.0808041105  0.781
2008 Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, ... ... Velculescu VE, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (New York, N.Y.). 321: 1801-6. PMID 18772397 DOI: 10.1126/Science.1164368  0.794
2008 Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, ... ... Velculescu VE, et al. An integrated genomic analysis of human glioblastoma multiforme. Science (New York, N.Y.). 321: 1807-12. PMID 18772396 DOI: 10.1126/Science.1164382  0.791
2008 Chan TA, Glockner S, Yi JM, Chen W, Van Neste L, Cope L, Herman JG, Velculescu V, Schuebel KE, Ahuja N, Baylin SB. Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. Plos Medicine. 5: e114. PMID 18507500 DOI: 10.1371/Journal.Pmed.0050114  0.45
2008 Velculescu VE. Defining the blueprint of the cancer genome. Carcinogenesis. 29: 1087-91. PMID 18495658 DOI: 10.1093/carcin/bgn096  0.449
2008 Picelli S, Vandrovcova J, Jones S, Djureinovic T, Skoglund J, Zhou XL, Velculescu VE, Vogelstein B, Lindblom A. Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q Bmc Cancer. 8. PMID 18380902 DOI: 10.1186/1471-2407-8-87  0.304
2008 Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, Traulsen A, Nowak MA, Siegel C, Velculescu VE, Kinzler KW, Vogelstein B, Willis J, Markowitz SD. Comparative lesion sequencing provides insights into tumor evolution. Proceedings of the National Academy of Sciences of the United States of America. 105: 4283-8. PMID 18337506 DOI: 10.1073/Pnas.0712345105  0.409
2008 Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, Shen D, Barrett I, Nouhi Y, Spencer F, Markowitz S, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C, Hieter P. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 105: 3443-8. PMID 18299561 DOI: 10.1073/Pnas.0712384105  0.338
2008 Segal NH, Parsons DW, Peggs KS, Velculescu V, Kinzler KW, Vogelstein B, Allison JP. Epitope landscape in breast and colorectal cancer Cancer Research. 68: 889-892. PMID 18245491 DOI: 10.1158/0008-5472.Can-07-3095  0.394
2007 Beerenwinkel N, Antal T, Dingli D, Traulsen A, Kinzler KW, Velculescu VE, Vogelstein B, Nowak MA. Genetic progression and the waiting time to cancer. Plos Computational Biology. 3: e225. PMID 17997597 DOI: 10.1371/Journal.Pcbi.0030225  0.383
2007 Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, ... ... Velculescu VE, et al. The genomic landscapes of human breast and colorectal cancers. Science (New York, N.Y.). 318: 1108-13. PMID 17932254 DOI: 10.1126/science.1145720  0.799
2007 Leary RJ, Cummins J, Wang TL, Velculescu VE. Digital karyotyping. Nature Protocols. 2: 1973-86. PMID 17703209 DOI: 10.1038/nprot.2007.276  0.724
2007 Lin J, Gan CM, Zhang X, Jones S, Sjöblom T, Wood LD, Parsons DW, Papadopoulos N, Kinzler KW, Vogelstein B, Parmigiani G, Velculescu VE. A multidimensional analysis of genes mutated in breast and colorectal cancers Genome Research. 17: 1304-1318. PMID 17693572 DOI: 10.1101/Gr.6431107  0.37
2006 Edkins S, O'Meara S, Parker A, Stevens C, Reis M, Jones S, Greenman C, Davies H, Dalgliesh G, Forbes S, Hunter C, Smith R, Stephens P, Goldstraw P, Nicholson A, ... ... Velculescu VE, et al. Recurrent KRAS codon 146 mutations in human colorectal cancer. Cancer Biology & Therapy. 5: 928-32. PMID 16969076 DOI: 10.4161/Cbt.5.8.3251  0.36
2006 Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, ... ... Velculescu VE, et al. The consensus coding sequences of human breast and colorectal cancers Science. 314: 268-274. PMID 16959974 DOI: 10.1126/science.1133427  0.791
2006 Wood LD, Calhoun ES, Silliman N, Ptak J, Szabo S, Powell SM, Riggins GJ, Wang TL, Yan H, Gazdar A, Kern SE, Pennacchio L, Kinzler KW, Vogelstein B, Velculescu VE. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers Human Mutation.. 27: 1060-1061. PMID 16941478 DOI: 10.1002/Humu.9452  0.399
2006 Nakayama K, Nakayama N, Kurman RJ, Cope L, Pohl G, Samuels Y, Velculescu VE, Wang TL, Shih IeM. Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biology & Therapy. 5: 779-85. PMID 16721043  0.407
2006 Nakayama K, Nakayama N, Davidson B, Katabuchi H, Kurman RJ, Velculescu VE, Shih IeM, Wang TL. Homozygous deletion of MKK4 in ovarian serous carcinoma. Cancer Biology & Therapy. 5: 630-4. PMID 16627982  0.315
2006 Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, ... Velculescu VE, et al. The colorectal microRNAome. Proceedings of the National Academy of Sciences of the United States of America. 103: 3687-92. PMID 16505370 DOI: 10.1073/Pnas.0511155103  0.687
2005 Samuels Y, Diaz LA, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell. 7: 561-73. PMID 15950905 DOI: 10.1016/J.Ccr.2005.05.014  0.377
2005 Bardelli A, Velculescu VE. Mutational analysis of gene families in human cancer. Current Opinion in Genetics & Development. 15: 5-12. PMID 15661527 DOI: 10.1016/j.gde.2004.12.009  0.417
2004 Barber TD, Vogelstein B, Kinzler KW, Velculescu VE. Somatic mutations of EGFR in colorectal cancers and glioblastomas [6] New England Journal of Medicine. 351: 2883. PMID 15625347 DOI: 10.1056/Nejm200412303512724  0.354
2004 Bentires-Alj M, Paez JG, David FS, Keilhack H, Halmos B, Naoki K, Maris JM, Richardson A, Bardelli A, Sugarbaker DJ, Richards WG, Du J, Girard L, Minna JD, Loh ML, ... ... Velculescu VE, et al. Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Research. 64: 8816-20. PMID 15604238 DOI: 10.1158/0008-5472.Can-04-1923  0.323
2004 Samuels Y, Velculescu VE. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle (Georgetown, Tex.). 3: 1221-4. PMID 15467468 DOI: 10.4161/cc.3.10.1164  0.372
2004 Broderick DK, Di C, Parrett TJ, Samuels YR, Cummins JM, McLendon RE, Fults DW, Velculescu VE, Bigner DD, Yan H. Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer Research. 64: 5048-50. PMID 15289301 DOI: 10.1158/0008-5472.Can-04-1170  0.411
2004 Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, Peters BA, Velculescu VE, Park BH. The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biology & Therapy. 3: 772-5. PMID 15254419 DOI: 10.4161/Cbt.3.8.994  0.338
2004 Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, ... ... Velculescu VE, et al. Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science (New York, N.Y.). 304: 1164-6. PMID 15155950 DOI: 10.1126/Science.1096096  0.384
2004 Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz SD, Goldberg ML, ... ... Velculescu VE, et al. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Research. 64: 2998-3001. PMID 15126332 DOI: 10.1158/0008-5472.Can-04-0587  0.331
2004 Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C. Inactivation of hCDC4 can cause chromosomal instability Nature. 428: 77-81. PMID 14999283 DOI: 10.1038/Nature02313  0.31
2004 Wang TL, Diaz LA, Romans K, Bardelli A, Saha S, Galizia G, Choti M, Donehower R, Parmigiani G, Shih IM, Iacobuzio-Donahue C, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients Proceedings of the National Academy of Sciences of the United States of America. 101: 3089-3094. PMID 14970324 DOI: 10.1073/Pnas.0308716101  0.326
2003 Bardelli A, Saha S, Sager JA, Romans KE, Xin B, Markowitz SD, Lengauer C, Velculescu VE, Kinzler KW, Vogelstein B. PRL-3 Expression in Metastatic Cancers Clinical Cancer Research. 9: 5607-5615. PMID 14654542  0.306
2003 Buckhaults P, Zhang Z, Chen YC, Wang TL, St Croix B, Saha S, Bardelli A, Morin PJ, Polyak K, Hruban RH, Velculescu VE, Shih IeM. Identifying tumor origin using a gene expression-based classification map. Cancer Research. 63: 4144-9. PMID 12874019  0.316
2002 Wang TL, Maierhofer C, Speicher MR, Lengauer C, Vogelstein B, Kinzler KW, Velculescu VE. Digital karyotyping. Proceedings of the National Academy of Sciences of the United States of America. 99: 16156-61. PMID 12461184 DOI: 10.1073/Pnas.202610899  0.305
2002 Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. RAF/RAS oncogenes and mismatch-repair status Nature. 418: 934. PMID 12198537 DOI: 10.1038/418934A  0.358
2002 Wang TL, Rago C, Silliman N, Ptak J, Markowitz S, Willson JK, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE. Prevalence of somatic alterations in the colorectal cancer cell genome. Proceedings of the National Academy of Sciences of the United States of America. 99: 3076-80. PMID 11867767 DOI: 10.1073/Pnas.261714699  0.432
2001 Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B. A phosphatase associated with metastasis of colorectal cancer. Science (New York, N.Y.). 294: 1343-6. PMID 11598267 DOI: 10.1126/Science.1065817  0.365
2001 Howe JR, Bair JL, Sayed MG, Anderson ME, Mitros FA, Petersen GM, Velculescu VE, Traverso G, Vogelstein B. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nature Genetics. 28: 184-7. PMID 11381269 DOI: 10.1038/88919  0.308
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