Neil Ruderman - Publications

Boston University, Boston, MA, United States 
Medicine and Surgery, Molecular Biology, Endocrinology Biology

85 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. The effects of troglitazone on AMPK in HepG2 cells. Archives of Biochemistry and Biophysics. PMID 28526426 DOI: 10.1016/  0.48
2016 Attané C, Peyot ML, Lussier R, Poursharifi P, Zhao S, Zhang D, Morin J, Pineda M, Wang S, Dumortier O, Ruderman NB, Mitchell GA, Simons B, Madiraju SR, Joly E, et al. A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice. Diabetologia. PMID 27677764 DOI: 10.1007/s00125-016-4105-2  0.4
2016 Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Knockdown of GSK3β Increases Basal Autophagy and AMPK Signaling in Nutrient-laden Human Aortic Endothelial Cells. Bioscience Reports. PMID 27534430 DOI: 10.1042/BSR20160174  0.64
2016 Weikel KA, Ruderman NB, Cacicedo JM. Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights. Metabolism: Clinical and Experimental. 65: 634-45. PMID 27085772 DOI: 10.1016/j.metabol.2016.01.005  0.64
2016 Pepin É, Al-Mass A, Attané C, Zhang K, Lamontagne J, Lussier R, Madiraju SR, Joly E, Ruderman NB, Sladek R, Prentki M, Peyot ML. Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression. Plos One. 11: e0153017. PMID 27043434 DOI: 10.1371/journal.pone.0153017  0.4
2016 Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. The Journal of Biological Chemistry. PMID 26797128 DOI: 10.1074/jbc.M115.696849  0.48
2015 Nolan CJ, Ruderman NB, Kahn SE, Pedersen O, Prentki M. Response to Comments on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673-686. Diabetes. 64: e38-9. PMID 26405280 DOI: 10.2337/dbi15-0002  0.4
2015 Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. Plos One. 10: e0127388. PMID 25996822 DOI: 10.1371/journal.pone.0127388  0.6
2015 Brandon AE, Tid-Ang J, Wright LE, Stuart E, Suryana E, Bentley N, Turner N, Cooney GJ, Ruderman NB, Kraegen EW. Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. Plos One. 10: e0121959. PMID 25798922 DOI: 10.1371/journal.pone.0121959  0.6
2015 Nolan CJ, Ruderman NB, Kahn SE, Pedersen O, Prentki M. Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes. Diabetes. 64: 673-86. PMID 25713189 DOI: 10.2337/db14-0694  0.4
2015 Ido Y, Duranton A, Lan F, Weikel KA, Breton L, Ruderman NB. Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes. Plos One. 10: e0115341. PMID 25647160 DOI: 10.1371/journal.pone.0115341  0.64
2015 Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. American Journal of Physiology. Cell Physiology. 308: C249-63. PMID 25354528 DOI: 10.1152/ajpcell.00265.2014  0.64
2014 Gauthier MS, Pérusse JR, Lavoie MÈ, Sladek R, Madiraju SR, Ruderman NB, Coulombe B, Prentki M, Rabasa-Lhoret R. Increased subcutaneous adipose tissue expression of genes involved in glycerolipid-fatty acid cycling in obese insulin-resistant versus -sensitive individuals. The Journal of Clinical Endocrinology and Metabolism. 99: E2518-28. PMID 25210878 DOI: 10.1210/jc.2014-1662  0.6
2014 Valentine RJ, Coughlan KA, Ruderman NB, Saha AK. Insulin inhibits AMPK activity and phosphorylates AMPK Ser⁴⁸⁵/⁴⁹¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Archives of Biochemistry and Biophysics. 562: 62-9. PMID 25172224 DOI: 10.1016/  0.6
2014 Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 7: 241-53. PMID 25018645 DOI: 10.2147/DMSO.S43731  0.6
2014 Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. Plos One. 9: e97554. PMID 24835252 DOI: 10.1371/journal.pone.0097554  0.64
2013 Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. Nutrient Excess in AMPK Downregulation and Insulin Resistance. Journal of Endocrinology, Diabetes & Obesity. 1: 1008. PMID 26120590  0.48
2013 Nolan CJ, Ruderman NB, Prentki M. Intensive insulin for type 2 diabetes: the risk of causing harm. The Lancet. Diabetes & Endocrinology. 1: 9-10. PMID 24622256 DOI: 10.1016/S2213-8587(13)70027-5  0.6
2013 Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. The Journal of Clinical Investigation. 123: 2764-72. PMID 23863634 DOI: 10.1172/JCI67227  0.6
2013 Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, ... ... Ruderman NB, et al. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Molecular Cell. 50: 686-98. PMID 23746352 DOI: 10.1016/j.molcel.2013.05.012  0.6
2013 Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot ML, Ruderman NB, Nolan CJ, Joly E, Madiraju SR, Poitout V, Prentki M. Pioglitazone acutely reduces energy metabolism and insulin secretion in rats. Diabetes. 62: 2122-9. PMID 23378607 DOI: 10.2337/db12-0428  0.6
2012 Ido Y, Duranton A, Lan F, Cacicedo JM, Chen TC, Breton L, Ruderman NB. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. Plos One. 7: e35092. PMID 22514710 DOI: 10.1371/journal.pone.0035092  0.64
2012 Ix JH, Biggs ML, Mukamal KJ, Kizer JR, Zieman SJ, Siscovick DS, Mozzaffarian D, Jensen MK, Nelson L, Ruderman N, Djousse L. Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study. Circulation. 125: 2316-22. PMID 22511752 DOI: 10.1161/CIRCULATIONAHA.111.072751  0.6
2012 Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. American Journal of Physiology. Cell Physiology. 303: C4-C13. PMID 22378745 DOI: 10.1152/ajpcell.00296.2011  0.6
2012 Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. Journal of Lipid Research. 53: 792-801. PMID 22323564 DOI: 10.1194/jlr.P022905  0.64
2011 Saha AK, Xu XJ, Balon TW, Brandon A, Kraegen EW, Ruderman NB. Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation? Cell Cycle (Georgetown, Tex.). 10: 3447-51. PMID 22067655 DOI: 10.4161/cc.10.20.17886  0.6
2011 Chuang JH, Kao YJ, Ruderman NB, Tung LC, Lin Y. Optimal concentrations of N-decanoyl-N-methylglucamine and sodium dodecyl sulfate allow the extraction and analysis of membrane proteins. Analytical Biochemistry. 418: 298-300. PMID 21871431 DOI: 10.1016/j.ab.2011.08.006  0.6
2011 Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 124: 806-13. PMID 21788586 DOI: 10.1161/CIRCULATIONAHA.110.003418  0.6
2011 Cacicedo JM, Gauthier MS, Lebrasseur NK, Jasuja R, Ruderman NB, Ido Y. Acute exercise activates AMPK and eNOS in the mouse aorta. American Journal of Physiology. Heart and Circulatory Physiology. 301: H1255-65. PMID 21724864 DOI: 10.1152/ajpheart.01279.2010  0.64
2011 Brandon AE, Hoy AJ, Wright LE, Turner N, Hegarty BD, Iseli TJ, Julia Xu X, Cooney GJ, Saha AK, Ruderman NB, Kraegen EW. The evolution of insulin resistance in muscle of the glucose infused rat. Archives of Biochemistry and Biophysics. 509: 133-41. PMID 21420928 DOI: 10.1016/  0.6
2011 Cacicedo JM, Benjachareonwong S, Chou E, Yagihashi N, Ruderman NB, Ido Y. Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. Investigative Ophthalmology & Visual Science. 52: 3630-9. PMID 21345991 DOI: 10.1167/iovs.10-5784  0.6
2011 Gauthier MS, O'Brien EL, Bigornia S, Mott M, Cacicedo JM, Xu XJ, Gokce N, Apovian C, Ruderman N. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochemical and Biophysical Research Communications. 404: 382-7. PMID 21130749 DOI: 10.1016/j.bbrc.2010.11.127  0.6
2010 Gauthier MS, Ruderman NB. Adipose tissue inflammation and insulin resistance: all obese humans are not created equal. The Biochemical Journal. 430: e1-4. PMID 20704568 DOI: 10.1042/BJ20101062  0.48
2010 Saha AK, Xu XJ, Lawson E, Deoliveira R, Brandon AE, Kraegen EW, Ruderman NB. Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes. 59: 2426-34. PMID 20682696 DOI: 10.2337/db09-1870  0.48
2010 Liu Q, Gauthier MS, Sun L, Ruderman N, Lodish H. Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: Requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio Faseb Journal. 24: 4229-4239. PMID 20667975 DOI: 10.1096/fj.10-159723  0.6
2010 Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/nature08778  0.6
2010 Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y. AMPK and SIRT1: a long-standing partnership? American Journal of Physiology. Endocrinology and Metabolism. 298: E751-60. PMID 20103737 DOI: 10.1152/ajpendo.00745.2009  0.64
2009 Joly E, Roduit R, Peyot ML, Habinowski SA, Ruderman NB, Witters LA, Prentki M. Glucose represses PPARα gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic β-cell. Journal of Diabetes. 1: 263-72. PMID 20923527 DOI: 10.1111/j.1753-0407.2009.00043.x  0.6
2009 Bendayan M, Londono I, Kemp BE, Hardie GD, Ruderman N, Prentki M. Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 57: 963-71. PMID 19581628 DOI: 10.1369/jhc.2009.954016  0.6
2009 Kelly M, Gauthier MS, Saha AK, Ruderman NB. Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. Diabetes. 58: 1953-60. PMID 19502419 DOI: 10.2337/db08-1293  0.48
2009 Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metabolism. 9: 428-39. PMID 19416713 DOI: 10.1016/j.cmet.2009.04.001  0.48
2009 Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, Madiraju SR, Nolan CJ, Prentki M. Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology. 150: 3465-74. PMID 19406947 DOI: 10.1210/en.2008-1557  0.6
2009 Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M. Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. The Journal of Biological Chemistry. 284: 16848-59. PMID 19389712 DOI: 10.1074/jbc.M109.006650  0.6
2009 Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochemical and Biophysical Research Communications. 378: 836-41. PMID 19071085 DOI: 10.1016/j.bbrc.2008.11.130  0.6
2008 Lan F, Cacicedo JM, Ruderman N, Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. The Journal of Biological Chemistry. 283: 27628-35. PMID 18687677 DOI: 10.1074/jbc.M805711200  0.64
2008 Gauthier MS, Miyoshi H, Souza SC, Cacicedo JM, Saha AK, Greenberg AS, Ruderman NB. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. The Journal of Biological Chemistry. 283: 16514-24. PMID 18390901 DOI: 10.1074/jbc.M708177200  0.6
2007 Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF, Vita JA. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 2650-6. PMID 17932315 DOI: 10.1161/ATVBAHA.107.153288  0.6
2006 Ruderman NB, Keller C, Richard AM, Saha AK, Luo Z, Xiang X, Giralt M, Ritov VB, Menshikova EV, Kelley DE, Hidalgo J, Pedersen BK, Kelly M. Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes. 55: S48-54. PMID 17130644 DOI: 10.2337/diabetes.  0.48
2006 Saha AK, Persons K, Safer JD, Luo Z, Holick MF, Ruderman NB. AMPK regulation of the growth of cultured human keratinocytes. Biochemical and Biophysical Research Communications. 349: 519-24. PMID 16949049 DOI: 10.1016/j.bbrc.2006.08.107  0.48
2006 Ruderman NB, Saha AK. Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Obesity (Silver Spring, Md.). 14: 25S-33S. PMID 16642960 DOI: 10.1038/oby.2006.279  0.48
2006 LeBrasseur NK, Kelly M, Tsao TS, Farmer SR, Saha AK, Ruderman NB, Tomas E. Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. American Journal of Physiology. Endocrinology and Metabolism. 291: E175-81. PMID 16464908 DOI: 10.1152/ajpendo.00453.2005  0.6
2006 Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, et al. Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. American Journal of Physiology. Endocrinology and Metabolism. 290: E1296-303. PMID 16434556 DOI: 10.1152/ajpendo.00341.2005  0.6
2006 Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. The Journal of Biological Chemistry. 281: 2654-60. PMID 16326714 DOI: 10.1074/jbc.M505311200  0.48
2006 Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB. Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. American Journal of Physiology. Endocrinology and Metabolism. 290: E471-9. PMID 16234268 DOI: 10.1152/ajpendo.00316.2005  0.48
2005 Joly E, Bendayan M, Roduit R, Saha AK, Ruderman NB, Prentki M. Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes. Febs Letters. 579: 6581-6. PMID 16298369 DOI: 10.1016/j.febslet.2005.10.050  0.6
2005 Miller TA, LeBrasseur NK, Cote GM, Trucillo MP, Pimentel DR, Ido Y, Ruderman NB, Sawyer DB. Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. Biochemical and Biophysical Research Communications. 336: 309-15. PMID 16126172 DOI: 10.1016/j.bbrc.2005.08.088  0.64
2005 Assifi MM, Suchankova G, Constant S, Prentki M, Saha AK, Ruderman NB. AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. American Journal of Physiology. Endocrinology and Metabolism. 289: E794-800. PMID 15956049 DOI: 10.1152/ajpendo.00144.2005  0.6
2005 Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y. Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes. 54: 1838-45. PMID 15919807 DOI: 10.2337/diabetes.54.6.1838  0.6
2005 Luo Z, Saha AK, Xiang X, Ruderman NB. AMPK, the metabolic syndrome and cancer. Trends in Pharmacological Sciences. 26: 69-76. PMID 15681023 DOI: 10.1016/  0.48
2005 Suchankova G, Tekle M, Saha AK, Ruderman NB, Clarke SD, Gettys TW. Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats. Biochemical and Biophysical Research Communications. 326: 851-8. PMID 15607747 DOI: 10.1016/j.bbrc.2004.11.114  0.48
2005 Roepstorff C, Halberg N, Hillig T, Saha AK, Ruderman NB, Wojtaszewski JF, Richter EA, Kiens B. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. American Journal of Physiology. Endocrinology and Metabolism. 288: E133-42. PMID 15383373 DOI: 10.1152/ajpendo.00379.2004  0.48
2004 Cacicedo JM, Yagihashi N, Keaney JF, Ruderman NB, Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications. 324: 1204-9. PMID 15504342 DOI: 10.1016/j.bbrc.2004.09.177  0.64
2004 Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. The Journal of Biological Chemistry. 279: 47898-905. PMID 15371448 DOI: 10.1074/jbc.M408149200  0.6
2004 Xiang X, Saha AK, Wen R, Ruderman NB, Luo Z. AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochemical and Biophysical Research Communications. 321: 161-7. PMID 15358229 DOI: 10.1016/j.bbrc.2004.06.133  0.6
2004 Tomas E, Kelly M, Xiang X, Tsao TS, Keller C, Keller P, Luo Z, Lodish H, Saha AK, Unger R, Ruderman NB. Metabolic and hormonal interactions between muscle and adipose tissue. The Proceedings of the Nutrition Society. 63: 381-5. PMID 15294059 DOI: 10.1079/PNS2004356  0.48
2004 Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, Xiang X, Giralt M, Hidalgo J, Saha AK, Pedersen BK, Ruderman NB. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochemical and Biophysical Research Communications. 320: 449-54. PMID 15219849 DOI: 10.1016/j.bbrc.2004.05.188  0.48
2004 Ruderman N, Prentki M. AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nature Reviews. Drug Discovery. 3: 340-51. PMID 15060529 DOI: 10.1038/nrd1344  0.6
2004 Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Massé F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes. 53: 1007-19. PMID 15047616 DOI: 10.2337/diabetes.53.4.1007  0.6
2004 Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB. Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochemical and Biophysical Research Communications. 314: 580-5. PMID 14733947  0.48
2003 Saha AK, Ruderman NB. Malonyl-CoA and AMP-activated protein kinase: an expanding partnership. Molecular and Cellular Biochemistry. 253: 65-70. PMID 14619957  0.48
2003 Tsao TS, Tomas E, Murrey HE, Hug C, Lee DH, Ruderman NB, Heuser JE, Lodish HF. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. The Journal of Biological Chemistry. 278: 50810-7. PMID 14522956 DOI: 10.1074/jbc.M309469200  0.6
2003 Ruderman NB, Saha AK, Kraegen EW. Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. Endocrinology. 144: 5166-71. PMID 14500570 DOI: 10.1210/en.2003-0849  0.48
2003 Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB. Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes. 52: 1635-40. PMID 12829626  0.48
2003 Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochemical Society Transactions. 31: 202-6. PMID 12546685 DOI: 10.1042/  0.6
2003 Båvenholm PN, Kuhl J, Pigon J, Saha AK, Ruderman NB, Efendic S. Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. The Journal of Clinical Endocrinology and Metabolism. 88: 82-7. PMID 12519834 DOI: 10.1210/jc.2002-020330  0.48
2003 Zinman B, Ruderman N, Campaigne BN, Devlin JT, Schneider SH. Physical activity/exercise and diabetes mellitus. Diabetes Care. 26: S73-7. PMID 12502622  0.6
2002 Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc, Itani SI, Lodish HF, Ruderman NB. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation Proceedings of the National Academy of Sciences of the United States of America. 99: 16309-16313. PMID 12456889 DOI: 10.1073/pnas.222657499  0.6
2002 Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW. AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes. 51: 2886-94. PMID 12351423  0.48
2002 Shafrir E, Ziv E, Saha AK, Ruderman NB. Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus. Diabetes/Metabolism Research and Reviews. 18: 217-23. PMID 12112940 DOI: 10.1002/dmrr.288  0.48
2002 Tomás E, Lin YS, Dagher Z, Saha A, Luo Z, Ido Y, Ruderman NB. Hyperglycemia and insulin resistance: possible mechanisms. Annals of the New York Academy of Sciences. 967: 43-51. PMID 12079834  0.64
2002 Park H, Kaushik VK, Constant S, Prentki M, Przybytkowski E, Ruderman NB, Saha AK. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. The Journal of Biological Chemistry. 277: 32571-7. PMID 12065578 DOI: 10.1074/jbc.M201692200  0.6
2002 Eckel RH, Wassef M, Chait A, Sobel B, Barrett E, King G, Lopes-Virella M, Reusch J, Ruderman N, Steiner G, Vlassara H. Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes Circulation. 105: e138-143. PMID 11994264  0.6
2002 Xiang X, Yuan M, Song Y, Ruderman N, Wen R, Luo Z. 14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1. Molecular Endocrinology (Baltimore, Md.). 16: 552-62. PMID 11875115 DOI: 10.1210/mend.16.3.0790  0.6
2002 Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. 51: 159-67. PMID 11756336  0.6
1999 Ruderman NB, Saha AK, Vavvas D, Witters LA. Malonyl-CoA, fuel sensing, and insulin resistance. American Journal of Physiology. Endocrinology and Metabolism. 276: E1-E18. PMID 29590890 DOI: 10.1152/ajpendo.1999.276.1.E1  0.48
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