Nir Barzilai - Publications

Yeshiva University, New York, NY, United States 
Genetics, Aging, Molecular Biology

179 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kulkarni AS, Aleksic S, Berger DM, Sierra F, Kuchel GA, Barzilai N. Geroscience-guided repurposing of FDA-approved drugs to target aging: A proposed process and prioritization. Aging Cell. e13596. PMID 35343051 DOI: 10.1111/acel.13596  0.669
2020 Kulkarni AS, Peck BD, Walton RG, Kern PA, Mar JC, Windham ST, Bamman MM, Barzilai N, Peterson CA. Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults. Aging. 12. PMID 33071237 DOI: 10.18632/aging.104096  0.664
2020 Justice JN, Gubbi S, Kulkarni AS, Bartley JM, Kuchel GA, Barzilai N. A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin. Geroscience. PMID 32902818 DOI: 10.1007/s11357-020-00261-6  0.655
2020 Barzilai N, Appleby JC, Austad SN, Cuervo AM, Kaeberlein M, Gonzalez-Billault C, Lederman S, Stambler I, Sierra F. Geroscience in the Age of COVID-19. Aging and Disease. 11: 725-729. PMID 32765937 DOI: 10.14336/Ad.2020.0629  0.31
2020 Sathyan S, Ayers E, Gao T, Milman S, Barzilai N, Verghese J. Plasma proteomic profile of frailty. Aging Cell. e13193. PMID 32762010 DOI: 10.1111/Acel.13193  0.301
2020 Zhang WB, Aleksic S, Gao T, Weiss EF, Demetriou E, Verghese J, Holtzer R, Barzilai N, Milman S. Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults. Cells. 9. PMID 32492897 DOI: 10.3390/Cells9061368  0.351
2020 Kulkarni AS, Gubbi S, Barzilai N. Benefits of Metformin in Attenuating the Hallmarks of Aging. Cell Metabolism. PMID 32333835 DOI: 10.1016/J.Cmet.2020.04.001  0.694
2020 Rozanov L, Ravichandran M, Grigolon G, Zanellati MC, Mansfeld J, Zarse K, Barzilai N, Atzmon G, Fischer F, Ristow M. Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A. Redox Biology. 32: 101448. PMID 32203922 DOI: 10.1016/J.Redox.2020.101448  0.368
2019 Lehallier B, Gate D, Schaum N, Nanasi T, Lee SE, Yousef H, Moran Losada P, Berdnik D, Keller A, Verghese J, Sathyan S, Franceschi C, Milman S, Barzilai N, Wyss-Coray T. Undulating changes in human plasma proteome profiles across the lifespan. Nature Medicine. 25: 1843-1850. PMID 31806903 DOI: 10.1038/S41591-019-0673-2  0.367
2019 Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner MI, Jensen MB, Calkhoven CF, Chen D, Grey ADNJ, Feige JN, Georgievskaya A, Gladyshev VN, Golato T, Gudkov AV, et al. Latest advances in aging research and drug discovery. Aging. 11. PMID 31770722 DOI: 10.18632/Aging.102487  0.329
2019 Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, ... ... Barzilai N, et al. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nature Communications. 10: 3669. PMID 31413261 DOI: 10.1038/S41467-019-11558-2  0.33
2019 Newman JC, Sokoloski JL, Robbins PD, Niedernhofer LJ, Reed MJ, Wei J, Austad SN, Barzilai N, Cohen HJ, Kuchel GA, Kirkland JL, Pignolo RJ. Creating the Next Generation of Translational Geroscientists. Journal of the American Geriatrics Society. PMID 31287934 DOI: 10.1111/Jgs.16055  0.303
2019 Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, et al. Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series. Journal of the American Geriatrics Society. PMID 30693953 DOI: 10.1111/Jgs.15788  0.341
2019 Fleming GA, Zhao JH, Seoh TC, Barzilai N. A Regulatory Pathway for Medicines That Target Aging Public Policy & Aging Report. 29: 128-133. DOI: 10.1093/Ppar/Prz018  0.309
2019 Justice JN, Kuchel GA, Barzilai N, Kritchevsky S. BIOMARKER STRATEGIES FOR GEROSCIENCE-GUIDED CLINICAL TRIALS Innovation in Aging. 3: S745-S746. DOI: 10.1093/Geroni/Igz038.2731  0.331
2018 Walters RO, Arias E, Diaz A, Burgos ES, Guan F, Tiano S, Mao K, Green CL, Qiu Y, Shah H, Wang D, Hudgins AD, Tabrizian T, Tosti V, Shechter D, ... ... Barzilai N, et al. Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. Cell Reports. 25: 663-676.e6. PMID 30332646 DOI: 10.1016/J.Celrep.2018.09.065  0.373
2018 Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, et al. APOE Alleles and Extreme Human Longevity. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 30060062 DOI: 10.1093/Gerona/Gly174  0.339
2018 Mao K, Quipildor GF, Tabrizian T, Novaj A, Guan F, Walters RO, Delahaye F, Hubbard GB, Ikeno Y, Ejima K, Li P, Allison DB, Salimi-Moosavi H, Beltran PJ, Cohen P, ... Barzilai N, et al. Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nature Communications. 9: 2394. PMID 29921922 DOI: 10.1038/S41467-018-04805-5  0.35
2018 Sathyan S, Barzilai N, Atzmon G, Milman S, Ayers E, Verghese J. Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty. Frontiers in Medicine. 5: 105. PMID 29765957 DOI: 10.3389/Fmed.2018.00105  0.323
2018 Gubbi S, Quipildor GF, Barzilai N, Huffman DM, Milman S. IGF-1: The Jekyll & Hyde of the aging brain. Journal of Molecular Endocrinology. PMID 29739805 DOI: 10.1530/Jme-18-0093  0.356
2018 Kulkarni AS, Brutsaert EF, Anghel V, Zhang K, Bloomgarden N, Pollak M, Mar JC, Hawkins M, Crandall JP, Barzilai N. Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults. Aging Cell. PMID 29383869 DOI: 10.1111/Acel.12723  0.786
2018 Barzilai N. HOW TO PROVE THAT AGING CAN BE TAMED AND THAT APPROPRIATE REGULATION CAN BE FOLLOWED? Innovation in Aging. 2: 544-544. DOI: 10.1093/Geroni/Igy023.2008  0.326
2017 Knight CM, Gutierrez-Juarez R, Lam TKT, Arrieta-Cruz I, Huang L, Schwartz G, Barzilai N, Rossetti L. Erratum. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol's Effects on Insulin Action in Rats. Diabetes 2011;60:2691-2700. Diabetes. 66: 3143-3144. PMID 29162736 DOI: 10.2337/Db17-Er12C  0.328
2017 Martinez-Lopez N, Tarabra E, Toledo M, Garcia-Macia M, Sahu S, Coletto L, Batista-Gonzalez A, Barzilai N, Pessin JE, Schwartz GJ, Kersten S, Singh R. System-wide Benefits of Intermeal Fasting by Autophagy. Cell Metabolism. PMID 29107505 DOI: 10.1016/J.Cmet.2017.09.020  0.358
2017 Ben-Avraham D, Govindaraju DR, Budagov T, Fradin D, Durda P, Liu B, Ott S, Gutman D, Sharvit L, Kaplan R, Bougnères P, Reiner A, Shuldiner AR, Cohen P, Barzilai N, et al. The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. Science Advances. 3: e1602025. PMID 28630896 DOI: 10.1126/Sciadv.1602025  0.332
2017 Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, ... ... Barzilai N, et al. A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. PMID 28341696 DOI: 10.2337/Db16-1329  0.4
2017 Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, et al. Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 28329397 DOI: 10.1093/Gerona/Glx041  0.758
2016 Hodes RJ, Sierra F, Austad SN, Epel E, Neigh GN, Erlandson KM, Schafer MJ, LeBrasseur NK, Wiley C, Campisi J, Sehl ME, Scalia R, Eguchi S, Kasinath BS, Halter JB, ... ... Barzilai N, et al. Disease drivers of aging. Annals of the New York Academy of Sciences. 1386: 45-68. PMID 27943360 DOI: 10.1111/Nyas.13299  0.323
2016 Huffman DM, Justice JN, Stout MB, Kirkland JL, Barzilai N, Austad SN. Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27535967 DOI: 10.1093/Gerona/Glw106  0.316
2016 Justice J, Miller JD, Newman JC, Hashmi SK, Halter J, Austad SN, Barzilai N, Kirkland JL. Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27535966 DOI: 10.1093/Gerona/Glw126  0.31
2016 Heo HJ, Tozour JN, Delahaye F, Zhao Y, Cui L, Barzilai N, Einstein FH. Advanced aging phenotype is revealed by epigenetic modifications in rat liver after in utero malnutrition. Aging Cell. PMID 27470058 DOI: 10.1111/Acel.12505  0.369
2016 Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA. Metformin as a Tool to Target Aging. Cell Metabolism. 23: 1060-5. PMID 27304507 DOI: 10.1016/J.Cmet.2016.05.011  0.34
2016 Milman S, Huffman DM, Barzilai N. The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research. Cell Metabolism. 23: 980-9. PMID 27304500 DOI: 10.1016/J.Cmet.2016.05.014  0.396
2016 Marzec M, Hawkes CP, Eletto D, Boyle S, Rosenfeld R, Hwa V, Wit JM, van Duyvenvoorde HA, Oostdijk W, Losekoot M, Pedersen O, Beng Yeap B, Flicker L, Barzilai N, Atzmon G, et al. A human variant of Glucose-regulated protein 94 that inefficiently supports IGF production. Endocrinology. en20152058. PMID 26982636 DOI: 10.1210/En.2015-2058  0.359
2016 Milman S, Barzilai N. Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span. Cold Spring Harbor Perspectives in Medicine. 6: a025098. PMID 26637439 DOI: 10.1101/Cshperspect.A025098  0.373
2015 Fortney K, Dobriban E, Garagnani P, Pirazzini C, Monti D, Mari D, Atzmon G, Barzilai N, Franceschi C, Owen AB, Kim SK. Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity. Plos Genetics. 11: e1005728. PMID 26677855 DOI: 10.1371/Journal.Pgen.1005728  0.319
2015 Huffman DM, Farias Quipildor G, Mao K, Zhang X, Wan J, Apontes P, Cohen P, Barzilai N. Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline. Aging Cell. PMID 26534869 DOI: 10.1111/Acel.12415  0.459
2015 Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 14: 497-510. PMID 25902704 DOI: 10.1111/Acel.12338  0.337
2015 Han J, Atzmon G, Barzilai N, Suh Y. Genetic variation in Sirtuin 1 (SIRT1) is associated with lipid profiles but not with longevity in Ashkenazi Jews. Translational Research : the Journal of Laboratory and Clinical Medicine. 165: 480-1. PMID 25305471 DOI: 10.1016/J.Trsl.2014.09.008  0.327
2014 Ayers E, Barzilai N, Crandall JP, Milman S, Verghese J. Association of exceptional parental longevity and physical function in aging. Age (Dordrecht, Netherlands). 36: 9677. PMID 24997018 DOI: 10.1007/S11357-014-9677-5  0.303
2014 Eny KM, Lutgers HL, Maynard J, Klein BE, Lee KE, Atzmon G, Monnier VM, van Vliet-Ostaptchouk JV, Graaff R, van der Harst P, Snieder H, van der Klauw MM, Sell DR, Hosseini SM, Cleary PA, ... ... Barzilai N, et al. GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence. Diabetologia. 57: 1623-34. PMID 24934506 DOI: 10.1007/S00125-014-3286-9  0.317
2014 Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell. 13: 769-71. PMID 24618355 DOI: 10.1111/Acel.12213  0.314
2014 Kolovou G, Barzilai N, Caruso C, Sikora E, Capri M, Tzanetakou IP, Bilianou H, Avery P, Katsiki N, Panotopoulos G, Franceschi C, Benetos A, Mikhailidis DP. The challenges in moving from ageing to successful longevity. Current Vascular Pharmacology. 12: 662-73. PMID 24350930 DOI: 10.2174/1570161111666131219095114  0.344
2014 Avery P, Barzilai N, Benetos A, Bilianou H, Capri M, Caruso C, Franceschi C, Katsiki N, Mikhailidis DP, Panotopoulos G, Sikora E, Tzanetakou IP, Kolovou G. Ageing, longevity, exceptional longevity and related genetic and non genetics markers: panel statement. Current Vascular Pharmacology. 12: 659-61. PMID 24350929 DOI: 10.2174/1570161111666131219101226  0.338
2014 Milman S, Atzmon G, Crandall J, Barzilai N. Phenotypes and genotypes of high density lipoprotein cholesterol in exceptional longevity. Current Vascular Pharmacology. 12: 690-7. PMID 24350928 DOI: 10.2174/1570161111666131219101551  0.34
2014 Chang AL, Atzmon G, Bergman A, Brugmann S, Atwood SX, Chang HY, Barzilai N. Identification of genes promoting skin youthfulness by genome-wide association study. The Journal of Investigative Dermatology. 134: 651-7. PMID 24037343 DOI: 10.1038/Jid.2013.381  0.304
2013 Kuliawat R, Klein L, Gong Z, Nicoletta-Gentile M, Nemkal A, Cui L, Bastie C, Su K, Huffman D, Surana M, Barzilai N, Fleischer N, Muzumdar R. Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 4890-8. PMID 23995290 DOI: 10.1096/Fj.13-231092  0.422
2013 Verghese J, Holtzer R, Wang C, Katz MJ, Barzilai N, Lipton RB. Role of APOE genotype in gait decline and disability in aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 1395-401. PMID 23902934 DOI: 10.1093/Gerona/Glt115  0.32
2013 Crandall JP, Barzilai N. Exploring the promise of resveratrol: where do we go from here? Diabetes. 62: 1022-3. PMID 23520278 DOI: 10.2337/Db12-1788  0.426
2013 Han J, Ryu S, Moskowitz DM, Rothenberg D, Leahy DJ, Atzmon G, Barzilai N, Suh Y. Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing. Mechanisms of Ageing and Development. 134: 478-85. PMID 23376243 DOI: 10.1016/J.Mad.2013.01.005  0.317
2013 Heo H, Huffman D, Delahaye F, Karakash S, Zhao Y, Barzilai N, Einstein F. 51: Moderate voluntary running protects against hepatic insulin resistance and restores the placenta-pup glucose uptake gradient in diet-induced obese pregnant rats American Journal of Obstetrics and Gynecology. 208: S30-S31. DOI: 10.1016/J.Ajog.2012.10.225  0.395
2012 Esterson YB, Kishore P, Koppaka S, Li W, Zhang K, Tonelli J, Lee DE, Kehlenbrink S, Lawrence S, Crandall J, Barzilai N, Hawkins M. Fatty acid-induced production of plasminogen activator inhibitor-1 by adipose macrophages is greater in middle-aged versus younger adult participants. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 1321-8. PMID 23089338 DOI: 10.1093/Gerona/Gls200  0.658
2012 Barzilai N, Ferrucci L. Insulin resistance and aging: a cause or a protective response? The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 1329-31. PMID 22859390 DOI: 10.1093/Gerona/Gls145  0.415
2012 Barzilai N, Guarente L, Kirkwood TB, Partridge L, Rando TA, Slagboom PE. The place of genetics in ageing research. Nature Reviews. Genetics. 13: 589-94. PMID 22777128 DOI: 10.1038/Nrg3290  0.336
2012 Barzilai N, Huffman DM, Muzumdar RH, Bartke A. The critical role of metabolic pathways in aging. Diabetes. 61: 1315-22. PMID 22618766 DOI: 10.2337/Db11-1300  0.434
2012 Huffman DM, Deelen J, Ye K, Bergman A, Slagboom EP, Barzilai N, Atzmon G. Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 1153-60. PMID 22496539 DOI: 10.1093/Gerona/Gls103  0.312
2012 Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell. 11: 475-81. PMID 22340368 DOI: 10.1111/J.1474-9726.2012.00808.X  0.312
2012 Crandall JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai N. Pilot study of resveratrol in older adults with impaired glucose tolerance. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 1307-12. PMID 22219517 DOI: 10.1093/Gerona/Glr235  0.655
2012 Ben-Shlomo S, Einstein FH, Zvibel I, Atias D, Shlomai A, Halpern Z, Barzilai N, Fishman S. Perinephric and epididymal fat affect hepatic metabolism in rats. Obesity (Silver Spring, Md.). 20: 151-6. PMID 21818154 DOI: 10.1038/Oby.2011.261  0.406
2012 Heo H, Karakash S, Huffman D, Delahaye F, Zhao Y, Barzilai N, Einstein F. 205: Sedentary behavior during pregnancy does not alter maternal fat distribution or insulin action American Journal of Obstetrics and Gynecology. 206: S103-S104. DOI: 10.1016/J.Ajog.2011.10.223  0.324
2012 Heo H, Slomko H, Karakash S, Delahaye F, Zhao Y, Huffman D, Barzilai N, Einstein F. 204: Impact of maternal diet on peripheral vs hepatic insulin resistance in young female offspring American Journal of Obstetrics and Gynecology. 206: S103. DOI: 10.1016/J.Ajog.2011.10.222  0.397
2011 Knight CM, Gutierrez-Juarez R, Lam TK, Arrieta-Cruz I, Huang L, Schwartz G, Barzilai N, Rossetti L. Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Diabetes. 60: 2691-700. PMID 21896928 DOI: 10.2337/Db10-0987  0.373
2011 Tazearslan C, Huang J, Barzilai N, Suh Y. Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles. Aging Cell. 10: 551-4. PMID 21388493 DOI: 10.1111/J.1474-9726.2011.00697.X  0.34
2011 Ben-Shlomo S, Zvibel I, Shnell M, Shlomai A, Chepurko E, Halpern Z, Barzilai N, Oren R, Fishman S. Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase. Journal of Hepatology. 54: 1214-23. PMID 21145820 DOI: 10.1016/J.Jhep.2010.09.032  0.337
2011 Heo H, Hou L, Karakash S, Zhao Y, Atzmon G, Barzilai N, Einstein F. 212: Metabolic alterations in visceral fat and liver contribute to persistent insulin resistance early postpartum American Journal of Obstetrics and Gynecology. 204: S93. DOI: 10.1016/J.Ajog.2010.10.228  0.388
2010 Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D, Bergman A. Genetic studies reveal the role of the endocrine and metabolic systems in aging. The Journal of Clinical Endocrinology and Metabolism. 95: 4493-500. PMID 20926537 DOI: 10.1210/Jc.2010-0859  0.378
2010 Einstein FH, Huffman DM, Fishman S, Jerschow E, Heo HJ, Atzmon G, Schechter C, Barzilai N, Muzumdar RH. Aging per se increases the susceptibility to free fatty acid-induced insulin resistance. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 800-8. PMID 20504893 DOI: 10.1093/Gerona/Glq078  0.428
2010 Thompson RF, Atzmon G, Gheorghe C, Liang HQ, Lowes C, Greally JM, Barzilai N. Tissue-specific dysregulation of DNA methylation in aging. Aging Cell. 9: 506-18. PMID 20497131 DOI: 10.1111/J.1474-9726.2010.00577.X  0.701
2010 Thompson RF, Fazzari MJ, Niu H, Barzilai N, Simmons RA, Greally JM. Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats. The Journal of Biological Chemistry. 285: 15111-8. PMID 20194508 DOI: 10.1074/Jbc.M109.095133  0.714
2010 Einstein F, Thompson RF, Bhagat TD, Fazzari MJ, Verma A, Barzilai N, Greally JM. Cytosine methylation dysregulation in neonates following intrauterine growth restriction. Plos One. 5: e8887. PMID 20126273 DOI: 10.1371/Journal.Pone.0008887  0.676
2010 Atzmon G, Cho M, Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, Suh Y. Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proceedings of the National Academy of Sciences of the United States of America. 107: 1710-7. PMID 19915151 DOI: 10.1073/Pnas.0906191106  0.351
2010 Barzilai N. Genetic and Epigenetic Contributions to Longevity Blood. 116. DOI: 10.1182/Blood.V116.21.Sci-1.Sci-1  0.374
2009 Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, et al. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. Plos One. 4: e8210. PMID 20011587 DOI: 10.1371/Journal.Pone.0008210  0.356
2009 Muniyappa R, Chen H, Muzumdar RH, Einstein FH, Yan X, Yue LQ, Barzilai N, Quon MJ. Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats. American Journal of Physiology. Endocrinology and Metabolism. 297: E1023-9. PMID 19706785 DOI: 10.1152/Ajpendo.00397.2009  0.423
2009 Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P. Humanin: a novel central regulator of peripheral insulin action. Plos One. 4: e6334. PMID 19623253 DOI: 10.1371/Journal.Pone.0006334  0.427
2009 Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner AH, Schork NJ, Hsueh WC, Reiner AP, Psaty BM, Atzmon G, Barzilai N, Cummings SR, Browner WS, et al. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell. 8: 460-72. PMID 19489743 DOI: 10.1111/J.1474-9726.2009.00493.X  0.381
2009 Huffman DM, Barzilai N. Role of visceral adipose tissue in aging. Biochimica Et Biophysica Acta. 1790: 1117-23. PMID 19364483 DOI: 10.1016/J.Bbagen.2009.01.008  0.404
2009 Walston JD, Matteini AM, Nievergelt C, Lange LA, Fallin DM, Barzilai N, Ziv E, Pawlikowska L, Kwok P, Cummings SR, Kooperberg C, LaCroix A, Tracy RP, Atzmon G, Lange EM, et al. Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. Experimental Gerontology. 44: 350-5. PMID 19249341 DOI: 10.1016/J.Exger.2009.02.004  0.302
2009 Barzilai N, Bartke A. Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 64: 187-91. PMID 19228789 DOI: 10.1093/Gerona/Gln061  0.314
2009 Barzilai N, Muzumdar R, Cohen P. Central regulation of peripheral insulin action Experimental Gerontology. 44: 123. DOI: 10.1016/J.Exger.2008.08.010  0.39
2009 Heo H, Donepudi R, Madankumar R, Huffman DM, Muzumdar R, Barzilai N, Einstein FH. 233: Hexosamine biosynthetic pathway: does it contribute to insulin resistance of pregnancy? American Journal of Obstetrics and Gynecology. 201: S97. DOI: 10.1016/J.Ajog.2009.10.248  0.358
2008 Einstein FH, Fishman S, Bauman J, Thompson RF, Huffman DM, Atzmon G, Barzilai N, Muzumdar RH. Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3450-7. PMID 18566293 DOI: 10.1096/Fj.08-109041  0.701
2008 Atzmon G, Pollin TI, Crandall J, Tanner K, Schechter CB, Scherer PE, Rincon M, Siegel G, Katz M, Lipton RB, Shuldiner AR, Barzilai N. Adiponectin levels and genotype: a potential regulator of life span in humans. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 63: 447-53. PMID 18511746 DOI: 10.1093/Gerona/63.5.447  0.351
2008 Muzumdar R, Allison DB, Huffman DM, Ma X, Atzmon G, Einstein FH, Fishman S, Poduval AD, McVei T, Keith SW, Barzilai N. Visceral adipose tissue modulates mammalian longevity. Aging Cell. 7: 438-40. PMID 18363902 DOI: 10.1111/J.1474-9726.2008.00391.X  0.364
2008 Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proceedings of the National Academy of Sciences of the United States of America. 105: 3438-42. PMID 18316725 DOI: 10.1073/Pnas.0705467105  0.396
2008 Einstein FH, Fishman S, Muzumdar RH, Yang XM, Atzmon G, Barzilai N. Accretion of visceral fat and hepatic insulin resistance in pregnant rats. American Journal of Physiology. Endocrinology and Metabolism. 294: E451-5. PMID 18073320 DOI: 10.1152/Ajpendo.00570.2007  0.398
2008 Barzilai N. Abstract ED04-02: The role of genes in protecting against age-related disease in cancer Cancer Prevention Research. 1. DOI: 10.1158/1940-6207.Prev-08-Ed04-02  0.383
2008 Einstein F, Heo H, Cui L, Huffman DM, Muzumdar RH, Barzilai N. 717: Physiological insulin resistance of pregnancy leads to increased glucose uptake rat pups American Journal of Obstetrics and Gynecology. 199: S205. DOI: 10.1016/J.Ajog.2008.09.748  0.399
2008 Einstein F, Thompson RF, Heo H, Budagov T, Atzmon G, Goffman D, Barzilai N, Montagna C, Greally JM. 600: Abnormal intrauterine growth induces global epigenetic changes in human stem cells American Journal of Obstetrics and Gynecology. 199: S173. DOI: 10.1016/J.Ajog.2008.09.630  0.653
2008 Heo H, Cui L, Muzumdar RH, Huffman DM, Barzilai N, Einstein F. 539: Hepatic and peripheral insulin resistance of pregnancy are not reversed in early postpartum rats American Journal of Obstetrics and Gynecology. 199: S158. DOI: 10.1016/J.Ajog.2008.09.569  0.35
2007 Hwang JH, Stein DT, Barzilai N, Cui MH, Tonelli J, Kishore P, Hawkins M. Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. American Journal of Physiology. Endocrinology and Metabolism. 293: E1663-9. PMID 17911339 DOI: 10.1152/Ajpendo.00590.2006  0.654
2007 Bergman A, Atzmon G, Ye K, MacCarthy T, Barzilai N. Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. Plos Computational Biology. 3: e170. PMID 17784782 DOI: 10.1371/Journal.Pcbi.0030170  0.366
2007 Martin GM, Bergman A, Barzilai N. Genetic determinants of human health span and life span: progress and new opportunities. Plos Genetics. 3: e125. PMID 17677003 DOI: 10.1371/Journal.Pgen.0030125  0.331
2007 Kim HS, Ali O, Shim M, Lee KW, Vuguin P, Muzumdar R, Barzilai N, Cohen P. Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo. Pediatric Research. 61: 159-64. PMID 17237715 DOI: 10.1203/Pdr.0B013E31802D8A30  0.425
2007 Fishman S, Muzumdar RH, Atzmon G, Ma X, Yang X, Einstein FH, Barzilai N. Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 53-60. PMID 17099068 DOI: 10.1096/Fj.06-6557Com  0.405
2007 Einstein FH, Lo LW, Muzumdar RH, Fishman S, Atzmon G, Barzilai N. 43: Recurrent pregnancy is associated with visceral adiposity and insulin resistance, but not beta-cell dysfunction in a rodent model American Journal of Obstetrics and Gynecology. 197: S19. DOI: 10.1016/J.Ajog.2007.10.048  0.338
2006 Muzumdar RH, Ma X, Fishman S, Yang X, Atzmon G, Vuguin P, Einstein FH, Hwang D, Cohen P, Barzilai N. Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action. Diabetes. 55: 2788-96. PMID 17003344 DOI: 10.2337/Db06-0318  0.42
2006 Atzmon G, Rincon M, Schechter CB, Shuldiner AR, Lipton RB, Bergman A, Barzilai N. Lipoprotein genotype and conserved pathway for exceptional longevity in humans. Plos Biology. 4: e113. PMID 16602826 DOI: 10.1371/Journal.Pbio.0040113  0.393
2006 Muzumdar RH, Ma X, Yang X, Atzmon G, Barzilai N. Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging. Neurobiology of Aging. 27: 1308-14. PMID 16122839 DOI: 10.1016/J.Neurobiolaging.2005.07.007  0.444
2006 Muzumdar R, Ma X, Yang X, Atzmon G, Cohen P, Barzilai N. OR13-4 DIRECT, CENTRAL, AND OPPOSING EFFECTS OF IGF-1 AND IGFBP-3 ON SYSTEMIC INSULIN ACTION Growth Hormone & Igf Research. 16: S25. DOI: 10.1016/S1096-6374(07)70260-5  0.364
2006 Einstein F, Fishman S, Muzumdar R, Yang XM, Atzmon G, Merkatz I, Barzilai N. Pregnancy alters adipose biology and its conribution to thrombosis, insulin action and inflammation American Journal of Obstetrics and Gynecology. 195: S152. DOI: 10.1016/J.Ajog.2006.10.537  0.369
2006 Einstein F, Fishman S, Muzumdar R, Yang XM, Atzmon G, Merkatz I, Barzilai N. Increased hepatic insulin resistance is detemined by visceral fat accretion and accumulation of hepatic triglycerides during pregnancy American Journal of Obstetrics and Gynecology. 195: S152. DOI: 10.1016/J.Ajog.2006.10.536  0.357
2005 Rincon M, Rudin E, Barzilai N. The insulin/IGF-1 signaling in mammals and its relevance to human longevity. Experimental Gerontology. 40: 873-7. PMID 16168602 DOI: 10.1016/J.Exger.2005.06.014  0.411
2005 Einstein FH, Atzmon G, Yang XM, Ma XH, Rincon M, Rudin E, Muzumdar R, Barzilai N. Differential responses of visceral and subcutaneous fat depots to nutrients. Diabetes. 54: 672-8. PMID 15734842 DOI: 10.2337/Diabetes.54.3.672  0.371
2005 Rudin E, Barzilai N. Inflammatory peptides derived from adipose tissue. Immunity & Ageing : I & A. 2: 1. PMID 15679897 DOI: 10.1186/1742-4933-2-1  0.34
2005 Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circulation Research. 96: 412-8. PMID 15677572 DOI: 10.1161/01.Res.0000157171.04054.30  0.305
2005 Atzmon G, Rincon M, Rabizadeh P, Barzilai N. Biological evidence for inheritance of exceptional longevity. Mechanisms of Ageing and Development. 126: 341-5. PMID 15621216 DOI: 10.1016/J.Mad.2004.08.026  0.348
2005 Globerson A, Barzilai N. The voyage to healthy longevity: from experimental models to the ultimate goal. Mechanisms of Ageing and Development. 126: 225-9. PMID 15621200 DOI: 10.1016/J.Mad.2004.08.013  0.308
2005 Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Combs TP, Rajala MW, Du X, Rollman B, Li W, Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, Brownlee M, et al. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. The Journal of Biological Chemistry. 280: 4617-26. PMID 15536073 DOI: 10.1074/Jbc.M411863200  0.656
2005 Rincon M, Muzumdar R, Atzmon G, Barzilai N. The paradox of the insulin/IGF-1 signaling pathway in longevity. Mechanisms of Ageing and Development. 125: 397-403. PMID 15272501 DOI: 10.1016/J.Mad.2004.03.006  0.419
2005 Einstein FH, Ma XH, Yang XM, Eric R, Muzumdar R, Merkatz IR, Barzilai N. Role of visceral fat in insulin resistance of pregnancy American Journal of Obstetrics and Gynecology. 193: S9. DOI: 10.1016/J.Ajog.2005.10.022  0.356
2004 Vuguin P, Raab E, Liu B, Barzilai N, Simmons R. Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation. Diabetes. 53: 2617-22. PMID 15448092 DOI: 10.2337/Diabetes.53.10.2617  0.451
2004 Barzilai N, Rossetti L, Lipton RB. Einstein's Institute for Aging Research: collaborative and programmatic approaches in the search for successful aging. Experimental Gerontology. 39: 151-7. PMID 15036407 DOI: 10.1016/J.Exger.2003.10.009  0.314
2004 Das M, Gabriely I, Barzilai N. Caloric restriction, body fat and ageing in experimental models. Obesity Reviews : An Official Journal of the International Association For the Study of Obesity. 5: 13-9. PMID 14969503 DOI: 10.1111/J.1467-789X.2004.00115.X  0.401
2004 Muzumdar R, Ma X, Atzmon G, Vuguin P, Yang X, Barzilai N. Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action. Diabetes. 53: 441-6. PMID 14747296 DOI: 10.2337/Diabetes.53.2.441  0.47
2004 Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, Barzilai N. Clinical phenotype of families with longevity. Journal of the American Geriatrics Society. 52: 274-7. PMID 14728640 DOI: 10.1111/J.1532-5415.2004.52068.X  0.314
2003 Atwood CS, Barzilai N, Bowen RL, Brown-Borg HM, Jarrard DF, Fu VX, Heilbronn LK, Ingram DK, Ravussin E, Schwartz RS, Weindruch R. Pennington scientific symposium on mechanisms and retardation of aging. Experimental Gerontology. 38: 1217-26. PMID 14580876 DOI: 10.1016/J.Exger.2003.08.005  0.353
2003 Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR. Unique lipoprotein phenotype and genotype associated with exceptional longevity. Jama. 290: 2030-40. PMID 14559957 DOI: 10.1016/J.Accreview.2003.12.029  0.328
2003 Gabriely I, Barzilai N. Surgical removal of visceral adipose tissue: effects on insulin action. Current Diabetes Reports. 3: 201-6. PMID 12762966 DOI: 10.1007/S11892-003-0064-3  0.436
2003 Muzumdar R, Ma X, Yang X, Atzmon G, Bernstein J, Karkanias G, Barzilai N. Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1130-2. PMID 12709405 DOI: 10.1096/Fj.02-0991Fje  0.424
2003 Ma X, Muzumdar R, Gabriely I, Atzmon G, Barzilai N. Does the brain lead the metabolic decline in aging? Clinical Neuroscience Research. 2: 339-344. DOI: 10.1016/S1566-2772(03)00011-2  0.433
2002 Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes. 51: 2951-8. PMID 12351432 DOI: 10.2337/Diabetes.51.10.2951  0.467
2002 Rajala MW, Lin Y, Ranalletta M, Yang XM, Qian H, Gingerich R, Barzilai N, Scherer PE. Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue. Molecular Endocrinology (Baltimore, Md.). 16: 1920-30. PMID 12145345 DOI: 10.1210/Me.2002-0048  0.339
2002 Ma XH, Muzumdar R, Yang XM, Gabriely I, Berger R, Barzilai N. Aging is associated with resistance to effects of leptin on fat distribution and insulin action. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 57: B225-31. PMID 12023258 DOI: 10.1093/Gerona/57.6.B225  0.446
2002 Gabriely I, Ma XH, Yang XM, Rossetti L, Barzilai N. Leptin resistance during aging is independent of fat mass. Diabetes. 51: 1016-21. PMID 11916920 DOI: 10.2337/Diabetes.51.4.1016  0.41
2002 Gabriely I, Yang XM, Cases JA, Ma XH, Rossetti L, Barzilai N. Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway. Atherosclerosis. 160: 115-22. PMID 11755928 DOI: 10.1016/S0021-9150(01)00574-3  0.387
2001 Wang J, Obici S, Morgan K, Barzilai N, Feng Z, Rossetti L. Overfeeding rapidly induces leptin and insulin resistance. Diabetes. 50: 2786-91. PMID 11723062 DOI: 10.2337/Diabetes.50.12.2786  0.427
2001 Lin Y, Rajala MW, Berger JP, Moller DE, Barzilai N, Scherer PE. Hyperglycemia-induced production of acute phase reactants in adipose tissue. The Journal of Biological Chemistry. 276: 42077-83. PMID 11546817 DOI: 10.1074/Jbc.M107101200  0.314
2001 Gabriely I, Barzilai N. The role of fat cell derived peptides in age-related metabolic alterations. Mechanisms of Ageing and Development. 122: 1565-76. PMID 11511397 DOI: 10.1016/S0047-6374(01)00287-1  0.353
2001 Gabriely I, Yang XM, Cases JA, Ma XH, Rossetti L, Barzilai N. Hyperglycemia modulates angiotensinogen gene expression. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 281: R795-802. PMID 11506994 DOI: 10.1152/Ajpregu.2001.281.3.R795  0.414
2001 Cases JA, Gabriely I, Ma XH, Yang XM, Michaeli T, Fleischer N, Rossetti L, Barzilai N. Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. Diabetes. 50: 348-52. PMID 11272146 DOI: 10.2337/Diabetes.50.2.348  0.43
2001 Vuguin P, Ma X, Yang X, Surana M, Liu B, Barzilai N. Food deprivation limits insulin secretory capacity in postpubertal rats. Pediatric Research. 49: 468-73. PMID 11264428 DOI: 10.1203/00006450-200104000-00006  0.419
2001 Barzilai N, Gabriely I. The role of fat depletion in the biological benefits of caloric restriction. The Journal of Nutrition. 131: 903S-906S. PMID 11238783 DOI: 10.1093/Jn/131.3.903S  0.339
2001 Barzilai N, Shuldiner AR. Searching for human longevity genes: the future history of gerontology in the post-genomic era. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 56: M83-7. PMID 11213281 DOI: 10.1093/Gerona/56.2.M83  0.31
2001 Cases JA, Barzilai N. The regulation of body fat distribution and the modulation of insulin action. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. S63-6. PMID 11126245 DOI: 10.1038/Sj.Ijo.0801508  0.423
2000 Barzilai N, Gupta G. Interaction between aging and syndrome X: new insights on the pathophysiology of fat distribution. Annals of the New York Academy of Sciences. 892: 58-72. PMID 10842652 DOI: 10.1111/J.1749-6632.1999.Tb07785.X  0.466
2000 Gupta G, Cases JA, She L, Ma XH, Yang XM, Hu M, Wu J, Rossetti L, Barzilai N. Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation. American Journal of Physiology. Endocrinology and Metabolism. 278: E985-91. PMID 10826999 DOI: 10.1152/Ajpendo.2000.278.6.E985  0.421
2000 Gupta G, She L, Ma XH, Yang XM, Hu M, Cases JA, Vuguin P, Rossetti L, Barzilai N. Aging does not contribute to the decline in insulin action on storage of muscle glycogen in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 278: R111-7. PMID 10644628 DOI: 10.1152/Ajpregu.2000.278.1.R111  0.416
1999 Hawkins M, Hu M, Yu J, Eder H, Vuguin P, She L, Barzilai N, Leiser M, Backer JM, Rossetti L. Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinositol 3-kinase activity Journal of Biological Chemistry. 274: 31312-31319. PMID 10531330 DOI: 10.1074/Jbc.274.44.31312  0.677
1999 Barzilai N, She L, Liu L, Wang J, Hu M, Vuguin P, Rossetti L. Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action. The American Journal of Physiology. 277: E291-8. PMID 10444425 DOI: 10.1152/Ajpendo.1999.277.2.E291  0.406
1999 Wang J, Liu R, Liu L, Chowdhury R, Barzilai N, Tan J, Rossetti L. The effect of leptin on Lep expression is tissue-specific and nutritionally regulated. Nature Medicine. 5: 895-9. PMID 10426312 DOI: 10.1038/11335  0.316
1999 Barzilai N, Gupta G. Revisiting the role of fat mass in the life extension induced by caloric restriction. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 54: B89-96; discussion B. PMID 10191831 DOI: 10.1093/Gerona/54.3.B89  0.388
1999 Barzilai N, She L, Liu BQ, Vuguin P, Cohen P, Wang J, Rossetti L. Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes. 48: 94-8. PMID 9892227 DOI: 10.2337/Diabetes.48.1.94  0.448
1999 Vuguin P, She L, Surana N, Liu B, Saenger P, Barzilai N. Marked Increase in the Ability of the β-Cells to Secrete Insulin in Response to Glucose and FFA Occurs Post-Puberty Pediatric Research. 45: 99A-99A. DOI: 10.1203/00006450-199904020-00593  0.391
1999 Barzilai N. Author's Repsonse to Commentary on "Revisiting the Role of Fat Mass in the Life Extension Induced by Caloric Restriction" The Journals of Gerontology Series a: Biological Sciences and Medical Sciences. 54: B98-B98. DOI: 10.1093/Gerona/54.3.B98  0.376
1998 Liu L, Karkanias GB, Morales JC, Hawkins M, Barzilai N, Wang J, Rossetti L. Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. The Journal of Biological Chemistry. 273: 31160-7. PMID 9813020 DOI: 10.1074/Jbc.273.47.31160  0.67
1998 Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature. 393: 684-8. PMID 9641678 DOI: 10.1038/31474  0.629
1998 Barzilai N, Banerjee S, Hawkins M, Chen W, Rossetti L. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. The Journal of Clinical Investigation. 101: 1353-61. PMID 9525977 DOI: 10.1172/Jci485  0.687
1998 Barzilai N, Banerjee S, Hawkins M, Chang CJ, Chen W, Rossetti L. The effect of age-dependent increase in fat mass on peripheral insulin action is saturable. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 53: B141-6. PMID 9520910 DOI: 10.1093/Gerona/53A.2.B141  0.697
1998 Massillon D, Chen W, Barzilai N, Prus-Wertheimer D, Hawkins M, Liu R, Taub R, Rossetti L. Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats. The Journal of Biological Chemistry. 273: 228-34. PMID 9417069 DOI: 10.1074/Jbc.273.1.228  0.618
1998 Barzilai N, Wang J, Massilon D, Vuguin P, Hawkins M, Rossetti L. Leptin selectively decreases visceral adiposity and enhances insulin action. The Journal of Clinical Investigation. 100: 3105-10. PMID 9399957 DOI: 10.1172/Jci119865  0.686
1997 Banerjee S, Saenger P, Hu M, Chen W, Barzilai N. Fat accretion and the regulation of insulin-mediated glycogen synthesis after puberty in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 273: R1534-R1539. PMID 29586743 DOI: 10.1152/Ajpregu.1997.273.4.R1534  0.413
1997 Rossetti L, Chen W, Hu M, Hawkins M, Barzilai N, Efrat S. Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. American Journal of Physiology. Endocrinology and Metabolism. 273: E743-E750. PMID 29585232 DOI: 10.1152/Ajpendo.1997.273.4.E743  0.657
1997 Rossetti L, Massillon D, Barzilai N, Vuguin P, Chen W, Hawkins M, Wu J, Wang J. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. The Journal of Biological Chemistry. 272: 27758-63. PMID 9346919 DOI: 10.1074/Jbc.272.44.27758  0.685
1997 Rossetti L, Stenbit AE, Chen W, Hu M, Barzilai N, Katz EB, Charron MJ. Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene Journal of Clinical Investigation. 100: 1831-1839. PMID 9312184 DOI: 10.1172/Jci119711  0.42
1997 Hawkins M, Barzilai N, Liu R, Hu M, Chen W, Rossetti L. Role of the glucosamine pathway in fat-induced insulin resistance. The Journal of Clinical Investigation. 99: 2173-82. PMID 9151789 DOI: 10.1172/Jci119390  0.671
1997 Raghavan S, Saenger P, Hu M, Barzilai N. Intracellular pathways of insulin-mediated glucose uptake before and after puberty in conscious rats. Pediatric Research. 41: 340-5. PMID 9078532 DOI: 10.1203/00006450-199703000-00006  0.439
1997 Hawkins M, Angelov I, Liu R, Barzilai N, Rossetti L. The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake. The Journal of Biological Chemistry. 272: 4889-95. PMID 9030547 DOI: 10.1074/Jbc.272.8.4889  0.666
1997 Massillon D, Barzilai N, Hawkins M, Prus-Wertheimer D, Rossetti L. Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion. Diabetes. 46: 153-7. PMID 8971097 DOI: 10.2337/Diab.46.1.153  0.669
1997 Banerjee S, Saenger P, Chen W, Rossetti L, Barzilai N. Prevention of Fat Accretion through Puberty restores Insulin Action on Glycogen Synthesis to Prepubertal Levels in Conscious Rats. † 373 Pediatric Research. 41: 65-65. DOI: 10.1203/00006450-199704001-00393  0.386
1996 Hawkins M, Barzilai N, Chen W, Angelov I, Hu M, Cohen P, Rossetti L. Increased hexosamine availability similarly impairs the action of insulin and IGF-1 on glucose disposal. Diabetes. 45: 1734-43. PMID 8922359 DOI: 10.2337/Diab.45.12.1734  0.673
1996 Barzilai N, Hawkins M, Angelov I, Hu M, Rossetti L. Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production. Diabetes. 45: 1329-35. PMID 8826967 DOI: 10.2337/Diab.45.10.1329  0.658
1996 Barzilai N, Rossetti L. Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats. The American Journal of Physiology. 270: E930-6. PMID 8764175 DOI: 10.1152/Ajpendo.1996.270.6.E930  0.463
1996 Barzilai N, Groop PH, Groop L, DeFronzo RA. A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin. Acta Diabetologica. 32: 273-8. PMID 8750768 DOI: 10.1007/Bf00576262  0.422
1996 Massillon D, Barzilai N, Chen W, Hu M, Rossetti L. Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats. The Journal of Biological Chemistry. 271: 9871-4. PMID 8626617 DOI: 10.1074/Jbc.271.17.9871  0.409
1996 Massillon D, Chen W, Hawkins M, Liu R, Barzilai N, Rossetti L. Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice. The American Journal of Physiology. 269: E1037-43. PMID 8572194 DOI: 10.1152/Ajpendo.1995.269.6.E1037  0.64
1996 Rossetti L, Barzilai N, Chen W, Harris T, Yang D, Rogler CE. Hepatic overexpression of insulin-like growth factor-II in adulthood increases basal and insulin-stimulated glucose disposal in conscious mice. The Journal of Biological Chemistry. 271: 203-8. PMID 8550560 DOI: 10.1074/Jbc.271.1.203  0.418
1995 Bali D, Svetlanov A, Lee HW, Fusco-DeMane D, Leiser M, Li B, Barzilai N, Surana M, Hou H, Fleischer N, DePinho R, Rossetti L, Efrat S. Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene Journal of Biological Chemistry. 270: 21464-21467. PMID 7665557 DOI: 10.1074/Jbc.270.37.21464  0.424
1995 Rossetti L, Hawkins M, Chen W, Gindi J, Barzilai N. In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. The Journal of Clinical Investigation. 96: 132-40. PMID 7615783 DOI: 10.1172/Jci118013  0.671
1995 Barzilai N, Massillon D, Rossetti L. Effects of fasting on hepatic and peripheral glucose metabolism in conscious rats with near-total fat depletion. The Biochemical Journal. 819-26. PMID 7575414 DOI: 10.1042/Bj3100819  0.417
1995 Barzilai N, Rossetti L. Relationship between changes in body composition and insulin responsiveness in models of the aging rat. The American Journal of Physiology. 269: E591-7. PMID 7573438 DOI: 10.1152/Ajpendo.1995.269.3.E591  0.456
1993 Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. The Journal of Clinical Investigation. 92: 1126-34. PMID 8397219 DOI: 10.1172/Jci116681  0.388
1992 DeFronzo RA, Barzilai N, Simonson DC. Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. The Journal of Clinical Endocrinology and Metabolism. 73: 1294-301. PMID 1955512 DOI: 10.1210/jcem-73-6-1294  0.302
1992 Barzilai N, Cohen P, Karnieli E, Enat R, Epstein O, Owen J, McIntyre N. In vivo insulin action in hepatocellular and cholestatic liver cirrhosis. Journal of Endocrinological Investigation. 14: 727-35. PMID 1761807 DOI: 10.1007/BF03347904  0.323
1991 Groop LC, Barzilai N, Ratheiser K, Luzi L, Wåhlin-Boll E, Melander A, DeFronzo RA. Dose-dependent effects of glyburide on insulin secretion and glucose uptake in humans. Diabetes Care. 14: 724-7. PMID 1954808 DOI: 10.2337/Diacare.14.8.724  0.412
1991 Barzilai N, Cohen P, Bar-Illan R, McIntyre N, Karnieli E. Case report: increased insulin sensitivity in tumor hypoglycemia in a diabetic patient: glucose metabolism in tumor hypoglycemia. The American Journal of the Medical Sciences. 302: 229-34. PMID 1656753 DOI: 10.1097/00000441-199110000-00007  0.314
1990 Cohen P, Harel C, Bergman R, Daoud D, Pam Z, Barzilai N, Armoni M, Karnieli E. Insulin resistance and acanthosis nigricans: evidence for a postbinding defect in vivo. Metabolism: Clinical and Experimental. 39: 1006-11. PMID 2215248 DOI: 10.1016/0026-0495(90)90158-9  0.316
1989 Barzilai N, Stessman J, Cohen P, Morali G, Barzilai D, Karnieli E. Glucoregulatory hormone influence on hepatic glucose production in the elderly Age. 12: 13-17. DOI: 10.1007/Bf02432513  0.342
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