Antonio Bedalov - Publications

Molecular and Cellular Biology University of Washington, Seattle, Seattle, WA 
Aging, Genetics, Molecular Biology

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Foss EJ, Sripathy S, Gatbonton-Schwager T, Kwak H, Thiesen AH, Lao U, Bedalov A. Chromosomal Mcm2-7 distribution and the genome replication program in species from yeast to humans. Plos Genetics. 17: e1009714. PMID 34473702 DOI: 10.1371/journal.pgen.1009714  1
2020 Dembitz V, Lalic H, Kodvanj I, Tomic B, Batinic J, Dubravcic K, Batinic D, Bedalov A, Visnjic D. 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts. Bmc Cancer. 20: 1090. PMID 33176741 DOI: 10.1186/s12885-020-07533-6  0.01
2020 Merlo LMF, Sprouffske K, Howard TC, Gardiner KL, Caulin AF, Blum SM, Evans P, Bedalov A, Sniegowski PD, Maley CC. Application of simultaneous selective pressures slows adaptation. Evolutionary Applications. 13: 1615-1625. PMID 32952608 DOI: 10.1111/Eva.13062  0.01
2020 Chowdhury S, Sripathy S, Webster A, Park A, Lao U, Hsu JH, Loe T, Bedalov A, Simon JA. Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies. Molecules (Basel, Switzerland). 25. PMID 31973227 DOI: 10.3390/Molecules25030455  1
2019 Dembitz V, Tomic B, Kodvanj I, Simon JA, Bedalov A, Visnjic D. The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 kinase via pyrimidine depletion. The Journal of Biological Chemistry. PMID 31431503 DOI: 10.1074/Jbc.Ra119.009396  1
2019 Foss EJ, Gatbonton-Schwager T, Thiesen AH, Taylor E, Soriano R, Lao U, MacAlpine DM, Bedalov A. Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats. Plos Genetics. 15: e1008138. PMID 31083663 DOI: 10.1371/Journal.Pgen.1008138  1
2018 Adrianse RL, Smith K, Gatbonton-Schwager T, Sripathy SP, Lao U, Foss EJ, Boers RG, Boers JB, Gribnau J, Bedalov A. Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion. Epigenetics & Chromatin. 11: 50. PMID 30170615 DOI: 10.1186/S13072-018-0219-8  1
2018 Foss EJ, Lao U, Bedalov A. G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome. Journal of Visualized Experiments : Jove. PMID 29630039 DOI: 10.3791/56286  1
2018 Leko V, Sripathy S, Adrianse RL, Loe T, Park A, Lao U, Foss EJ, Bartolomei MS, Bedalov A. Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome. Journal of Visualized Experiments : Jove. PMID 29553562 DOI: 10.3791/56398  1
2017 Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B, Paddison PJ, Grady WM, Lee JT, Bartolomei MS, Bedalov A. Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression. Proceedings of the National Academy of Sciences of the United States of America. PMID 28143937 DOI: 10.1073/Pnas.1621356114  1
2017 Foss EJ, Lao U, Dalrymple E, Adrianse RL, Loe T, Bedalov A. SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences. Proceedings of the National Academy of Sciences of the United States of America. PMID 28049846 DOI: 10.1073/Pnas.1614781114  1
2016 Lessing D, Dial TO, Wei C, Payer B, Carrette LL, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A, Theriault J, Hasaka T, Bedalov A, Bartolomei MS, Lee JT. A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation. Proceedings of the National Academy of Sciences of the United States of America. 113: 14366-14371. PMID 28182563 DOI: 10.1073/Pnas.1617597113  0.01
2016 Bedalov A, Chowdhury S, Simon JA. Biology, Chemistry, and Pharmacology of Sirtuins. Methods in Enzymology. 574: 183-211. PMID 27423863 DOI: 10.1016/Bs.Mie.2016.03.011  1
2016 Banfic H, Crljen V, Lukinovic-Skudar V, Dembitz V, Lalic H, Bedalov A, Visnjic D. Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length. Advances in Biological Regulation. 60: 22-8. PMID 26446451 DOI: 10.1016/j.jbior.2015.09.003  0.01
2016 Bedalov A, Chowdhury S, Simon JA. Biology, Chemistry, and Pharmacology of Sirtuins Methods in Enzymology. DOI: 10.1016/bs.mie.2016.03.011  1
2015 Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, ... ... Bedalov A, et al. Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. PMID 26176914 DOI: 10.1038/Nature14671  1
2015 Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, ... ... Bedalov A, et al. Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 521: E1-4. PMID 25993969 DOI: 10.1038/Nature14444  1
2014 Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD, Morrissey C, Corey E, Montgomery B, Mostaghel E, Clegg N, Coleman I, Brown CM, Schneider EL, Craik C, ... ... Bedalov A, et al. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discovery. 4: 1310-25. PMID 25122198 DOI: 10.1158/2159-8290.Cd-13-1010  1
2014 Mahajan SS, Scian M, Sripathy S, Posakony J, Lao U, Loe TK, Leko V, Thalhofer A, Schuler AD, Bedalov A, Simon JA. Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors. Journal of Medicinal Chemistry. 57: 3283-94. PMID 24697269 DOI: 10.1021/Jm4018064  1
2013 Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK. Sirtuins in yeast: phenotypes and tools. Methods in Molecular Biology (Clifton, N.J.). 1077: 11-37. PMID 24014397 DOI: 10.1007/978-1-62703-637-5_2  1
2013 Leko V, Park GJ, Lao U, Simon JA, Bedalov A. Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. Plos One. 8: e66283. PMID 23799088 DOI: 10.1371/Journal.Pone.0066283  1
2013 Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. Plos Genetics. 9: e1003329. PMID 23505383 DOI: 10.1371/Journal.Pgen.1003329  1
2013 Banfic H, Bedalov A, York JD, Visnjic D. Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 288: 1717-25. PMID 23179856 DOI: 10.1074/Jbc.M112.412288  0.01
2012 Foss EJ, Radulovic D, Stirewalt DL, Radich J, Sala-Torra O, Pogosova-Agadjanyan EL, Hengel SM, Loeb KR, Deeg HJ, Meshinchi S, Goodlett DR, Bedalov A. Proteomic classification of acute leukemias by alignment-based quantitation of LC-MS/MS data sets. Journal of Proteome Research. 11: 5005-10. PMID 22900933 DOI: 10.1021/Pr300567R  1
2012 Leko V, Varnum-Finney B, Li H, Gu Y, Flowers D, Nourigat C, Bernstein ID, Bedalov A. SIRT1 is dispensable for function of hematopoietic stem cells in adult mice. Blood. 119: 1856-60. PMID 22219225 DOI: 10.1182/Blood-2011-09-377077  1
2011 Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, ... ... Bedalov A, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature. 477: 482-5. PMID 21938067 DOI: 10.1038/Nature10296  1
2011 Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A. Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. Plos Biology. 9: e1001144. PMID 21909241 DOI: 10.1371/Journal.Pbio.1001144  1
2011 Kwan EX, Foss E, Kruglyak L, Bedalov A. Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. Plos Genetics. 7: e1002250. PMID 21901113 DOI: 10.1371/Journal.Pgen.1002250  1
2011 Mahajan SS, Leko V, Simon JA, Bedalov A. Sirtuin modulators. Handbook of Experimental Pharmacology. 206: 241-55. PMID 21879453 DOI: 10.1007/978-3-642-21631-2_11  1
2011 Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, Iraci N, Valli E, Ling D, Thomas W, van Bekkum M, Sekyere E, Jankowski K, Trahair T, Mackenzie KL, et al. SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. Plos Genetics. 7: e1002135. PMID 21698133 DOI: 10.1371/Journal.Pgen.1002135  1
2011 Nemecek ER, Guthrie KA, Sorror ML, Wood BL, Doney KC, Hilger RA, Scott BL, Kovacsovics TJ, Maziarz RT, Woolfrey AE, Bedalov A, Sanders JE, Pagel JM, Sickle EJ, Witherspoon R, et al. Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic cell transplantation for high-risk hematologic malignancies. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 17: 341-50. PMID 20685259 DOI: 10.1016/J.Bbmt.2010.05.007  1
2011 Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, Iraci N, MacKenzie KL, Haber M, Norris MD, Biankin AV, Perini G, Liu T. Abstract 3027: SIRT1 promotes N-Myc oncogenesis stabilizing N-Myc protein Cancer Research. 71: 3027-3027. DOI: 10.1158/1538-7445.Am2011-3027  1
2009 Newcomb B, Bedalov A. Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens. Methods in Molecular Biology (Clifton, N.J.). 548: 145-60. PMID 19521823 DOI: 10.1007/978-1-59745-540-4_8  1
2009 Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nature Medicine. 15: 206-10. PMID 19151729 DOI: 10.1038/Nm.1906  1
2008 Chevillet JR, Park GJ, Bedalov A, Simon JA, Vasioukhin VI. Identification and characterization of small-molecule inhibitors of hepsin. Molecular Cancer Therapeutics. 7: 3343-51. PMID 18852137 DOI: 10.1158/1535-7163.Mct-08-0446  1
2008 Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A, Giaever G, Nislow C, Merrill AR, Merrill RA, Lory S, et al. Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. Plos Genetics. 4: e1000005. PMID 18454192 DOI: 10.1371/Journal.Pgen.1000005  1
2007 Thaminy S, Newcomb B, Kim J, Gatbonton T, Foss E, Simon J, Bedalov A. Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56. The Journal of Biological Chemistry. 282: 37805-14. PMID 17977840 DOI: 10.1074/Jbc.M706384200  1
2007 Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. Genetic basis of proteome variation in yeast. Nature Genetics. 39: 1369-75. PMID 17952072 DOI: 10.1038/Ng.2007.22  1
2007 Chang C, Storer BE, Scott BL, Bryant EM, Shulman HM, Flowers ME, Sandmaier BM, Witherspoon RP, Nash RA, Sanders JE, Bedalov A, Hansen JA, Clurman BE, Storb R, Appelbaum FR, et al. Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic disorders. Blood. 110: 1379-87. PMID 17488876 DOI: 10.1182/Blood-2007-02-076307  1
2006 Foss E, Bedalov A. Pharmacogenetics: yeast lead the way. Chemistry & Biology. 13: 236-8. PMID 16638528 DOI: 10.1016/J.Chembiol.2006.03.001  1
2006 Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Research. 66: 4368-77. PMID 16618762 DOI: 10.1158/0008-5472.Can-05-3617  1
2006 Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. Plos Genetics. 2: e35. PMID 16552446 DOI: 10.1371/Journal.Pgen.0020035  1
2005 Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Substrate-specific activation of sirtuins by resveratrol. The Journal of Biological Chemistry. 280: 17038-45. PMID 15684413 DOI: 10.1074/Jbc.M500655200  1
2004 Posakony J, Hirao M, Bedalov A. Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast. Combinatorial Chemistry & High Throughput Screening. 7: 661-8. PMID 15578928 DOI: 10.2174/1386207043328346  1
2004 Bedalov A, Simon JA. Neuroscience. NAD to the rescue. Science (New York, N.Y.). 305: 954-5. PMID 15310883 DOI: 10.1126/Science.1102497  1
2004 Simon JA, Bedalov A. Yeast as a model system for anticancer drug discovery. Nature Reviews. Cancer. 4: 481-92. PMID 15170450 DOI: 10.1038/Nrc1372  1
2004 Posakony J, Hirao M, Stevens S, Simon JA, Bedalov A. Inhibitors of Sir2: evaluation of splitomicin analogues. Journal of Medicinal Chemistry. 47: 2635-44. PMID 15115404 DOI: 10.1021/Jm030473R  1
2003 Hirao M, Posakony J, Nelson M, Hruby H, Jung M, Simon JA, Bedalov A. Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast. The Journal of Biological Chemistry. 278: 52773-82. PMID 14534292 DOI: 10.1074/Jbc.M308966200  1
2003 Bedalov A, Hirao M, Posakony J, Nelson M, Simon JA. NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Molecular and Cellular Biology. 23: 7044-54. PMID 12972620 DOI: 10.1128/Mcb.23.19.7044-7054.2003  1
2003 Bedalov A, Simon JA. Sir2 flexes its muscle. Developmental Cell. 5: 188-9. PMID 12919668 DOI: 10.1016/S1534-5807(03)00237-5  1
2001 Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA. Identification of a small molecule inhibitor of Sir2p. Proceedings of the National Academy of Sciences of the United States of America. 98: 15113-8. PMID 11752457 DOI: 10.1073/Pnas.261574398  1
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