Antonio Bedalov - Publications

Molecular and Cellular Biology University of Washington, Seattle, Seattle, WA 
Aging, Genetics, Molecular Biology

23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, ... ... Bedalov A, et al. Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 521: E1-4. PMID 25993969 DOI: 10.1038/nature14444  0.4
2014 Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD, Morrissey C, Corey E, Montgomery B, Mostaghel E, Clegg N, Coleman I, Brown CM, Schneider EL, Craik C, ... ... Bedalov A, et al. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discovery. 4: 1310-25. PMID 25122198 DOI: 10.1158/2159-8290.CD-13-1010  0.4
2014 Mahajan SS, Scian M, Sripathy S, Posakony J, Lao U, Loe TK, Leko V, Thalhofer A, Schuler AD, Bedalov A, Simon JA. Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors. Journal of Medicinal Chemistry. 57: 3283-94. PMID 24697269 DOI: 10.1021/jm4018064  0.4
2013 Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK. Sirtuins in yeast: phenotypes and tools. Methods in Molecular Biology (Clifton, N.J.). 1077: 11-37. PMID 24014397 DOI: 10.1007/978-1-62703-637-5_2  0.4
2013 Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. Plos Genetics. 9: e1003329. PMID 23505383 DOI: 10.1371/journal.pgen.1003329  0.4
2011 Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, ... ... Bedalov A, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature. 477: 482-5. PMID 21938067 DOI: 10.1038/nature10296  0.4
2011 Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A. Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. Plos Biology. 9: e1001144. PMID 21909241 DOI: 10.1371/journal.pbio.1001144  0.4
2011 Kwan EX, Foss E, Kruglyak L, Bedalov A. Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. Plos Genetics. 7: e1002250. PMID 21901113 DOI: 10.1371/journal.pgen.1002250  0.4
2011 Mahajan SS, Leko V, Simon JA, Bedalov A. Sirtuin modulators. Handbook of Experimental Pharmacology. 206: 241-55. PMID 21879453 DOI: 10.1007/978-3-642-21631-2_11  0.4
2011 Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, Iraci N, Valli E, Ling D, Thomas W, van Bekkum M, Sekyere E, Jankowski K, Trahair T, Mackenzie KL, et al. SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. Plos Genetics. 7: e1002135. PMID 21698133 DOI: 10.1371/journal.pgen.1002135  0.4
2011 Nemecek ER, Guthrie KA, Sorror ML, Wood BL, Doney KC, Hilger RA, Scott BL, Kovacsovics TJ, Maziarz RT, Woolfrey AE, Bedalov A, Sanders JE, Pagel JM, Sickle EJ, Witherspoon R, et al. Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic cell transplantation for high-risk hematologic malignancies. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 17: 341-50. PMID 20685259 DOI: 10.1016/j.bbmt.2010.05.007  0.4
2009 Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nature Medicine. 15: 206-10. PMID 19151729 DOI: 10.1038/nm.1906  0.4
2008 Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A, Giaever G, Nislow C, Merrill AR, Merrill RA, Lory S, et al. Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. Plos Genetics. 4: e1000005. PMID 18454192 DOI: 10.1371/journal.pgen.1000005  0.4
2007 Thaminy S, Newcomb B, Kim J, Gatbonton T, Foss E, Simon J, Bedalov A. Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56. The Journal of Biological Chemistry. 282: 37805-14. PMID 17977840 DOI: 10.1074/jbc.M706384200  0.4
2007 Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. Genetic basis of proteome variation in yeast. Nature Genetics. 39: 1369-75. PMID 17952072 DOI: 10.1038/ng.2007.22  0.4
2006 Foss E, Bedalov A. Pharmacogenetics: yeast lead the way. Chemistry & Biology. 13: 236-8. PMID 16638528 DOI: 10.1016/j.chembiol.2006.03.001  0.4
2006 Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Research. 66: 4368-77. PMID 16618762 DOI: 10.1158/0008-5472.CAN-05-3617  0.4
2006 Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. Plos Genetics. 2: e35. PMID 16552446 DOI: 10.1371/journal.pgen.0020035  0.4
2005 Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Substrate-specific activation of sirtuins by resveratrol. The Journal of Biological Chemistry. 280: 17038-45. PMID 15684413 DOI: 10.1074/jbc.M500655200  0.4
2004 Posakony J, Hirao M, Bedalov A. Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast. Combinatorial Chemistry & High Throughput Screening. 7: 661-8. PMID 15578928  0.4
2004 Posakony J, Hirao M, Stevens S, Simon JA, Bedalov A. Inhibitors of Sir2: evaluation of splitomicin analogues. Journal of Medicinal Chemistry. 47: 2635-44. PMID 15115404 DOI: 10.1021/jm030473r  0.4
2003 Hirao M, Posakony J, Nelson M, Hruby H, Jung M, Simon JA, Bedalov A. Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast. The Journal of Biological Chemistry. 278: 52773-82. PMID 14534292 DOI: 10.1074/jbc.M308966200  0.4
2003 Bedalov A, Hirao M, Posakony J, Nelson M, Simon JA. NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Molecular and Cellular Biology. 23: 7044-54. PMID 12972620 DOI: 10.1128/MCB.23.19.7044-7054.2003  0.4
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