Reuben J. Shaw - Publications

Affiliations: 
Biology University of California, San Diego, La Jolla, CA 
Area:
Molecular Biology

90 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Schmitt DL, Curtis SD, Lyons AC, Zhang JF, Chen M, He CY, Mehta S, Shaw RJ, Zhang J. Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter. Nature Communications. 13: 3856. PMID 35790710 DOI: 10.1038/s41467-022-31190-x  0.421
2020 Van Nostrand JL, Hellberg K, Luo EC, Van Nostrand EL, Dayn A, Yu J, Shokhirev MN, Dayn Y, Yeo GW, Shaw RJ. AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation. Genes & Development. PMID 32912901 DOI: 10.1101/Gad.339895.120  0.462
2020 Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Rombold O, Agar NYR, Goodyear LJ, Shaw RJ, et al. PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. Cell Metabolism. PMID 32663458 DOI: 10.1016/J.Cmet.2020.06.017  0.388
2020 Schmitt DL, Zhang J, Chen M, Leung A, He CY, Curtis SD, Mehta S, Shaw RJ, Rangamani P, Zhang J. Illuminating Spatiotemporal Regulation of AMPK with a Genetically Encoded Excitation‐Ratiometric Biosensor for AMPK The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03063  0.306
2020 Garcia D, Mihaylova MM, Shaw RJ. AMPK: Central Regulator of Glucose and Lipid Metabolism and Target of Type 2 Diabetes Therapeutics Liver. 472-484. DOI: 10.1002/9781119436812.Ch38  0.727
2019 Stein BD, Calzolari D, Hellberg K, Hu YS, He L, Hung CM, Toyama EQ, Ross DS, Lillemeier BF, Cantley LC, Yates JR, Shaw RJ. Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. Cell Reports. 29: 3331-3348.e7. PMID 31801093 DOI: 10.1016/J.Celrep.2019.10.117  0.471
2019 Stein BD, Herzig S, Martínez-Bartolomé S, Lavallée-Adam M, Shaw RJ, Yates JR. Comparison of CRISPR Genomic Tagging and Endogenous Immunoprecipitation coupled with Quantitative Mass Spectrometry to Identify Dynamic AMPK alpha 2 Protein Interactions. Journal of Proteome Research. PMID 31398040 DOI: 10.1021/Acs.Jproteome.9B00378  0.307
2019 Rodón L, Svensson RU, Wiater E, Chun MGH, Tsai WW, Eichner LJ, Shaw RJ, Montminy M. The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer. Science Advances. 5: eaaw6455. PMID 31355336 DOI: 10.1126/Sciadv.Aaw6455  0.439
2019 Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ. The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC. Cancer Discovery. PMID 31350328 DOI: 10.1158/2159-8290.Cd-18-1261  0.438
2019 Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Sancho-Martinez I, Takahashi Y, Hatanaka F, Wu J, Ocampo A, Reddy P, Wu MZ, Gerken L, Shaw RJ, Rodriguez Esteban C, Benner C, Nakagawa H, et al. Mutations in foregut SOX2 cells induce efficient proliferation via CXCR2 pathway. Protein & Cell. PMID 31041783 DOI: 10.1007/S13238-019-0630-3  0.357
2019 Nassour J, Radford R, Correia A, Fusté JM, Schoell B, Jauch A, Shaw RJ, Karlseder J. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. PMID 30675059 DOI: 10.1038/S41586-019-0885-0  0.376
2019 Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell Reports. 26: 192-208.e6. PMID 30605676 DOI: 10.1016/J.Celrep.2018.12.036  0.382
2018 Limpert AS, Lambert LJ, Bakas NA, Bata N, Brun SN, Shaw RJ, Cosford NDP. Autophagy in Cancer: Regulation by Small Molecules. Trends in Pharmacological Sciences. 39: 1021-1032. PMID 30454769 DOI: 10.1016/J.Tips.2018.10.004  0.365
2018 Eichner LJ, Brun SN, Herzig S, Young NP, Curtis SD, Shackelford DB, Shokhirev MN, Leblanc M, Vera LI, Hutchins A, Ross DS, Shaw RJ, Svensson RU. Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models. Cell Metabolism. PMID 30415923 DOI: 10.1016/J.Cmet.2018.10.005  0.345
2018 Fiedler EC, Shaw RJ. AMPK Regulates the Epigenome through Phosphorylation of TET2. Cell Metabolism. 28: 534-536. PMID 30282044 DOI: 10.1016/J.Cmet.2018.09.015  0.437
2018 Hollstein PE, Shaw RJ. Inflamed T cells and stroma drive gut tumors. Science (New York, N.Y.). 361: 332-333. PMID 30049865 DOI: 10.1126/Science.Aau4804  0.364
2018 Hollstein PE, Shaw RJ. GNAS shifts metabolism in pancreatic cancer. Nature Cell Biology. PMID 29941928 DOI: 10.1038/S41556-018-0120-5  0.394
2017 Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nature Reviews. Molecular Cell Biology. PMID 28974774 DOI: 10.1038/Nrm.2017.95  0.475
2017 Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, ... ... Shaw RJ, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. PMID 28965760 DOI: 10.1016/J.Cell.2017.08.051  0.377
2017 Ruggero D, Shaw RJ. Editorial overview: Cell regulation: 1000 Flavors including chocolate and chili peppers. Current Opinion in Cell Biology. 45: iv-vi. PMID 28641761 DOI: 10.1016/J.Ceb.2017.05.008  0.383
2017 Garcia D, Shaw RJ. AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. Molecular Cell. 66: 789-800. PMID 28622524 DOI: 10.1016/J.Molcel.2017.05.032  0.471
2017 Svensson RU, Shaw RJ. Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer. Cold Spring Harbor Symposia On Quantitative Biology. PMID 28062532 DOI: 10.1101/Sqb.2016.81.030874  0.365
2016 Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. Cell Metabolism. PMID 28089566 DOI: 10.1016/J.Cmet.2016.12.009  0.425
2016 Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM. LKB1 promotes metabolic flexibility in response to energy stress. Metabolic Engineering. PMID 28034771 DOI: 10.1016/J.Ymben.2016.12.010  0.487
2016 Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, ... ... Shaw RJ, et al. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nature Medicine. PMID 27643638 DOI: 10.1038/Nm.4181  0.334
2016 Merkwirth C, Jovaisaite V, Durieux J, Matilainen O, Jordan SD, Quiros PM, Steffen KK, Williams EG, Mouchiroud L, Tronnes SU, Murillo V, Wolff SC, Shaw RJ, Auwerx J, Dillin A. Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity. Cell. PMID 27133168 DOI: 10.1016/J.Cell.2016.04.012  0.331
2016 Young NP, Kamireddy A, Van Nostrand JL, Eichner LJ, Shokhirev MN, Dayn Y, Shaw RJ. AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes & Development. 30: 535-52. PMID 26944679 DOI: 10.1101/Gad.274142.115  0.449
2016 Toyama EQ, Herzig S, Courchet J, Lewis TL, Losón OC, Hellberg K, Young NP, Chen H, Polleux F, Chan DC, Shaw RJ. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science (New York, N.Y.). 351: 275-281. PMID 26816379 DOI: 10.1126/Science.Aab4138  0.336
2015 Shaw RJ. AMPK Keeps Tumor Cells from Starving to Death. Cell Stem Cell. 17: 503-4. PMID 26544110 DOI: 10.1016/J.Stem.2015.10.007  0.447
2015 Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM, Brunet A. Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. Cell Metabolism. 22: 907-21. PMID 26456332 DOI: 10.1016/J.Cmet.2015.09.009  0.454
2015 Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Molecular Cell. PMID 26118643 DOI: 10.1016/J.Molcel.2015.05.031  0.465
2015 Shaw RJ. Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK. Current Biology : Cb. 25: R418-20. PMID 25989082 DOI: 10.1016/J.Cub.2015.03.019  0.37
2014 Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. Molecular Cell. 55: 436-50. PMID 25042806 DOI: 10.1016/J.Molcel.2014.06.021  0.477
2014 Mouchiroud L, Eichner LJ, Shaw RJ, Auwerx J. Transcriptional coregulators: fine-tuning metabolism. Cell Metabolism. 20: 26-40. PMID 24794975 DOI: 10.1016/J.Cmet.2014.03.027  0.401
2014 Luan B, Goodarzi MO, Phillips NG, Guo X, Chen YD, Yao J, Allison M, Rotter JI, Shaw R, Montminy M. Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metabolism. 19: 1058-65. PMID 24768298 DOI: 10.1016/J.Cmet.2014.03.024  0.383
2014 Faubert B, Vincent EE, Griss T, Samborska B, Izreig S, Svensson RU, Mamer OA, Avizonis D, Shackelford DB, Shaw RJ, Jones RG. Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. Proceedings of the National Academy of Sciences of the United States of America. 111: 2554-9. PMID 24550282 DOI: 10.1073/Pnas.1312570111  0.472
2014 Howell JJ, Hellberg K, Shaw RJ, Manning BD. Mechanisms and consequences of hepatic regulation of mTORC1 by metformin Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-P28  0.483
2014 Svensson R, Harriman G, Greenwood J, Bhat S, Harwood HJ, Kapeller R, Shaw R. Abstract 2679: Acetyl-CoA carboxylase inhibition by ND646 reduces fatty acid synthesis and inhibits cell proliferation in human non-small cell lung cancer cells Cancer Research. 74: 2679-2679. DOI: 10.1158/1538-7445.Am2014-2679  0.365
2013 Shaw RJ. Metformin trims fats to restore insulin sensitivity. Nature Medicine. 19: 1570-2. PMID 24309653 DOI: 10.1038/Nm.3414  0.377
2013 Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, Iwanami A, Liu F, Villa GR, Gu Y, Campos C, Zhu S, Yang H, Yong WH, Cloughesy TF, ... ... Shaw RJ, et al. mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metabolism. 18: 726-39. PMID 24140020 DOI: 10.1016/J.Cmet.2013.09.013  0.409
2013 Chun MG, Shaw RJ. Cancer metabolism in breadth and depth. Nature Biotechnology. 31: 505-7. PMID 23752435 DOI: 10.1038/Nbt.2611  0.363
2013 Shaw RJ. Cell biology. GATORs take a bite out of mTOR. Science (New York, N.Y.). 340: 1056-7. PMID 23723225 DOI: 10.1126/Science.1240315  0.46
2013 Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, ... ... Shaw RJ, et al. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discovery. 3: 870-9. PMID 23715154 DOI: 10.1158/2159-8290.Cd-13-0015  0.389
2013 Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell. 23: 143-58. PMID 23352126 DOI: 10.1016/J.Ccr.2012.12.008  0.422
2013 Mihaylova MM, Shaw RJ. Metabolic reprogramming by class I and II histone deacetylases. Trends in Endocrinology and Metabolism: Tem. 24: 48-57. PMID 23062770 DOI: 10.1016/J.Tem.2012.09.003  0.73
2013 Goodwin JM, Svensson RU, Shackelford DB, Winslow MM, Shaw RJ. Abstract A59: Dixdc1 links the LKB1 tumor suppressor to Snail, noncanonical Wnt signaling, and metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A59  0.426
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Shaw RJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.611
2012 Svensson RU, Shaw RJ. Cancer metabolism: Tumour friend or foe. Nature. 485: 590-1. PMID 22660317 DOI: 10.1038/485590A  0.356
2012 Shaw RJ, Cantley LC. Cell biology. Ancient sensor for ancient drug. Science (New York, N.Y.). 336: 813-4. PMID 22605741 DOI: 10.1126/Science.1223140  0.418
2012 Xia Y, Yeddula N, Leblanc M, Ke E, Zhang Y, Oldfield E, Shaw RJ, Verma IM. Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nature Cell Biology. 14: 257-65. PMID 22327365 DOI: 10.1038/Ncb2428  0.317
2012 Shaw RJ, Cantley LC. Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice. F1000 Biology Reports. 4: 2. PMID 22242042 DOI: 10.3410/B4-2  0.388
2012 Xia Y, Yeddula N, Leblanc M, Shaw R, Verma I. Abstract PR3: NSCLC and SCLC mouse models mediated by lentiviral gene delivery Clinical Cancer Research. 18: PR3-PR3. DOI: 10.1158/1078-0432.12Aacriaslc-Pr3  0.33
2011 Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nature Cell Biology. 13: 1016-23. PMID 21892142 DOI: 10.1038/Ncb2329  0.787
2011 Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell. 145: 607-21. PMID 21565617 DOI: 10.1016/J.Cell.2011.03.043  0.743
2011 Wang B, Moya N, Niessen S, Hoover H, Mihaylova MM, Shaw RJ, Yates JR, Fischer WH, Thomas JB, Montminy M. A hormone-dependent module regulating energy balance. Cell. 145: 596-606. PMID 21565616 DOI: 10.1016/J.Cell.2011.04.013  0.773
2011 Egan D, Kim J, Shaw RJ, Guan KL. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy. 7: 643-4. PMID 21460621 DOI: 10.4161/Auto.7.6.15123  0.488
2011 Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metabolism. 13: 376-88. PMID 21459323 DOI: 10.1016/J.Cmet.2011.03.009  0.754
2011 Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 470: 404-8. PMID 21331044 DOI: 10.1038/Nature09706  0.427
2011 Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, ... ... Shaw RJ, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (New York, N.Y.). 331: 456-61. PMID 21205641 DOI: 10.1126/Science.1196371  0.768
2010 Ohashi K, Ouchi N, Higuchi A, Shaw RJ, Walsh K. LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis. The Journal of Biological Chemistry. 285: 22291-8. PMID 20489196 DOI: 10.1074/Jbc.M110.123794  0.427
2010 Shaw RJ, Evans RM, Simon MC. Metabolism and cancer in La Jolla. Cancer Research. 70: 3864-9. PMID 20442287 DOI: 10.1158/0008-5472.Can-09-4529  0.418
2010 Shaw RJ. Metabolism and cancer mix in Madrid. Embo Reports. 11: 249-51. PMID 20300115 DOI: 10.1038/Embor.2010.40  0.342
2010 Gwinn DM, Asara JM, Shaw RJ. Raptor is phosphorylated by cdc2 during mitosis. Plos One. 5: e9197. PMID 20169205 DOI: 10.1371/Journal.Pone.0009197  0.79
2010 Gwinn DM, Shaw RJ. 3 – AMPK Control of mTOR Signaling and Growth The Enzymes. 28: 49-75. DOI: 10.1016/S1874-6047(10)28003-4  0.811
2009 Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF, Vasquez DS, Juguilon H, Panda S, Shaw RJ, Thompson CB, Evans RM. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (New York, N.Y.). 326: 437-40. PMID 19833968 DOI: 10.1126/Science.1172156  0.415
2009 Ikeda Y, Sato K, Pimentel DR, Sam F, Shaw RJ, Dyck JR, Walsh K. Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. The Journal of Biological Chemistry. 284: 35839-49. PMID 19828446 DOI: 10.1074/Jbc.M109.057273  0.356
2009 Shaw RJ. Tumor suppression by LKB1: SIK-ness prevents metastasis. Science Signaling. 2: pe55. PMID 19724060 DOI: 10.1126/Scisignal.286Pe55  0.451
2009 Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nature Reviews. Cancer. 9: 563-75. PMID 19629071 DOI: 10.1038/Nrc2676  0.468
2009 Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, Vera DR, Shaw RJ. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proceedings of the National Academy of Sciences of the United States of America. 106: 11137-42. PMID 19541609 DOI: 10.1073/Pnas.0900465106  0.39
2009 Shaw R, Dillin A. PPTR-1 counterAkts insulin signaling. Cell. 136: 816-8. PMID 19269361 DOI: 10.1016/J.Cell.2009.02.029  0.383
2009 Shaw RJ. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiologica (Oxford, England). 196: 65-80. PMID 19245654 DOI: 10.1111/J.1748-1716.2009.01972.X  0.544
2009 Mair W, Panowski SH, Shaw RJ, Dillin A. Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. Plos One. 4: e4535. PMID 19229346 DOI: 10.1371/Journal.Pone.0004535  0.351
2008 Shaw RJ. Raptor swoops in on metabolism. Cell Metabolism. 8: 343-4. PMID 19046565 DOI: 10.1016/J.Cmet.2008.10.007  0.42
2008 Shaw RJ. LKB1: cancer, polarity, metabolism, and now fertility. The Biochemical Journal. 416: e1-3. PMID 18939946 DOI: 10.1042/Bj20082023  0.472
2008 Shaw RJ. mTOR signaling: RAG GTPases transmit the amino acid signal. Trends in Biochemical Sciences. 33: 565-8. PMID 18929489 DOI: 10.1016/J.Tibs.2008.09.005  0.325
2008 Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. AMPK and PPARdelta agonists are exercise mimetics. Cell. 134: 405-15. PMID 18674809 DOI: 10.1016/J.Cell.2008.06.051  0.721
2008 Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Molecular Cell. 30: 214-26. PMID 18439900 DOI: 10.1016/J.Molcel.2008.03.003  0.77
2008 Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. AMPK and PPARδ Agonists Are Exercise Mimetics (DOI:10.1016/j.cell.2008.06.051) Cell. 135: 189. DOI: 10.1016/J.Cell.2008.09.014  0.7
2006 Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, ... ... Shaw RJ, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 444: 337-42. PMID 17086191 DOI: 10.1038/Nature05354  0.764
2006 Shaw RJ. Glucose metabolism and cancer. Current Opinion in Cell Biology. 18: 598-608. PMID 17046224 DOI: 10.1016/J.Ceb.2006.10.005  0.469
2006 Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth Nature. 441: 424-430. PMID 16724053 DOI: 10.1038/Nature04869  0.385
2005 Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (New York, N.Y.). 310: 1642-6. PMID 16308421 DOI: 10.1126/Science.1120781  0.433
2005 Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. The Journal of Biological Chemistry. 280: 15158-64. PMID 15713674 DOI: 10.1074/Jbc.M412065200  0.369
2004 Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 6: 91-9. PMID 15261145 DOI: 10.1016/J.Ccr.2004.06.007  0.453
2004 Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proceedings of the National Academy of Sciences of the United States of America. 101: 3329-35. PMID 14985505 DOI: 10.1073/Pnas.0308061100  0.525
2001 Shaw RJ, Paez JG, Curto M, Yaktine A, Pruitt WM, Saotome I, O'Bryan JP, Gupta V, Ratner N, Der CJ, Jacks T, McClatchey AI. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Developmental Cell. 1: 63-72. PMID 11703924 DOI: 10.1016/S1534-5807(01)00009-0  0.639
2001 Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death Molecular Cell. 7: 1307-1319. PMID 11430832 DOI: 10.1016/S1097-2765(01)00258-1  0.388
1998 Shaw RJ, McClatchey AI, Jacks T. Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. The Journal of Biological Chemistry. 273: 7757-64. PMID 9516485 DOI: 10.1074/Jbc.273.13.7757  0.661
1998 Shaw RJ, Henry M, Solomon F, Jacks T. RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. Molecular Biology of the Cell. 9: 403-19. PMID 9450964 DOI: 10.1091/Mbc.9.2.403  0.648
1995 Platko JV, Leonard DA, Adra CN, Shaw RJ, Cerione RA, Lim B. A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors Proceedings of the National Academy of Sciences of the United States of America. 92: 2974-2978. PMID 7708758 DOI: 10.1073/Pnas.92.7.2974  0.302
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