Reuben J. Shaw - Publications

Affiliations: 
Biology University of California, San Diego, La Jolla, CA 
Area:
Molecular Biology

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Eichner LJ, Brun SN, Herzig S, Young NP, Curtis SD, Shackelford DB, Shokhirev MN, Leblanc M, Vera LI, Hutchins A, Ross DS, Shaw RJ, Svensson RU. Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models. Cell Metabolism. PMID 30415923 DOI: 10.1016/j.cmet.2018.10.005  0.44
2016 Young NP, Kamireddy A, Van Nostrand JL, Eichner LJ, Shokhirev MN, Dayn Y, Shaw RJ. AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes & Development. 30: 535-52. PMID 26944679 DOI: 10.1101/gad.274142.115  0.44
2016 Toyama EQ, Herzig S, Courchet J, Lewis TL, Losón OC, Hellberg K, Young NP, Chen H, Polleux F, Chan DC, Shaw RJ. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science (New York, N.Y.). 351: 275-281. PMID 26816379 DOI: 10.1126/science.aab4138  0.44
2015 Shaw RJ. AMPK Keeps Tumor Cells from Starving to Death. Cell Stem Cell. 17: 503-4. PMID 26544110 DOI: 10.1016/j.stem.2015.10.007  0.44
2015 Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Molecular Cell. PMID 26118643 DOI: 10.1016/j.molcel.2015.05.031  0.44
2015 Shaw RJ. Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK. Current Biology : Cb. 25: R418-20. PMID 25989082 DOI: 10.1016/j.cub.2015.03.019  0.44
2014 Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. Molecular Cell. 55: 436-50. PMID 25042806 DOI: 10.1016/j.molcel.2014.06.021  0.44
2014 Faubert B, Vincent EE, Griss T, Samborska B, Izreig S, Svensson RU, Mamer OA, Avizonis D, Shackelford DB, Shaw RJ, Jones RG. Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. Proceedings of the National Academy of Sciences of the United States of America. 111: 2554-9. PMID 24550282 DOI: 10.1073/pnas.1312570111  0.44
2013 Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, Iwanami A, Liu F, Villa GR, Gu Y, Campos C, Zhu S, Yang H, Yong WH, Cloughesy TF, ... ... Shaw RJ, et al. mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metabolism. 18: 726-39. PMID 24140020 DOI: 10.1016/j.cmet.2013.09.013  0.44
2013 Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, ... ... Shaw RJ, et al. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discovery. 3: 870-9. PMID 23715154 DOI: 10.1158/2159-8290.CD-13-0015  0.44
2013 Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell. 23: 143-58. PMID 23352126 DOI: 10.1016/j.ccr.2012.12.008  0.44
2013 Mihaylova MM, Shaw RJ. Metabolic reprogramming by class I and II histone deacetylases. Trends in Endocrinology and Metabolism: Tem. 24: 48-57. PMID 23062770 DOI: 10.1016/j.tem.2012.09.003  0.76
2012 Shaw RJ, Cantley LC. Cell biology. Ancient sensor for ancient drug. Science (New York, N.Y.). 336: 813-4. PMID 22605741 DOI: 10.1126/science.1223140  0.44
2012 Xia Y, Yeddula N, Leblanc M, Ke E, Zhang Y, Oldfield E, Shaw RJ, Verma IM. Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nature Cell Biology. 14: 257-65. PMID 22327365 DOI: 10.1038/ncb2428  0.44
2012 Shaw RJ, Cantley LC. Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice. F1000 Biology Reports. 4: 2. PMID 22242042 DOI: 10.3410/B4-2  0.44
2011 Akhtar A, Fuchs E, Mitchison T, Shaw RJ, St Johnston D, Strasser A, Taylor S, Walczak C, Zerial M. A decade of molecular cell biology: achievements and challenges. Nature Reviews. Molecular Cell Biology. 12: 669-74. PMID 21941276 DOI: 10.1038/nrm3187  0.44
2011 Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nature Cell Biology. 13: 1016-23. PMID 21892142 DOI: 10.1038/ncb2329  0.76
2011 Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell. 145: 607-21. PMID 21565617 DOI: 10.1016/j.cell.2011.03.043  0.44
2011 Wang B, Moya N, Niessen S, Hoover H, Mihaylova MM, Shaw RJ, Yates JR, Fischer WH, Thomas JB, Montminy M. A hormone-dependent module regulating energy balance. Cell. 145: 596-606. PMID 21565616 DOI: 10.1016/j.cell.2011.04.013  0.44
2011 Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metabolism. 13: 376-88. PMID 21459323 DOI: 10.1016/j.cmet.2011.03.009  0.44
2011 Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 470: 404-8. PMID 21331044 DOI: 10.1038/nature09706  0.44
2011 Birnbaum MJ, Shaw RJ. Genomics: Drugs, diabetes and cancer. Nature. 470: 338-9. PMID 21331030 DOI: 10.1038/470338a  0.44
2011 Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, ... ... Shaw RJ, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (New York, N.Y.). 331: 456-61. PMID 21205641 DOI: 10.1126/science.1196371  0.44
2010 Shaw RJ, Evans RM, Simon MC. Metabolism and cancer in La Jolla. Cancer Research. 70: 3864-9. PMID 20442287 DOI: 10.1158/0008-5472.CAN-09-4529  0.44
2010 Gwinn DM, Asara JM, Shaw RJ. Raptor is phosphorylated by cdc2 during mitosis. Plos One. 5: e9197. PMID 20169205 DOI: 10.1371/journal.pone.0009197  0.52
2009 Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF, Vasquez DS, Juguilon H, Panda S, Shaw RJ, Thompson CB, Evans RM. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (New York, N.Y.). 326: 437-40. PMID 19833968 DOI: 10.1126/science.1172156  0.44
2009 Ikeda Y, Sato K, Pimentel DR, Sam F, Shaw RJ, Dyck JR, Walsh K. Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. The Journal of Biological Chemistry. 284: 35839-49. PMID 19828446 DOI: 10.1074/jbc.M109.057273  0.44
2009 Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nature Reviews. Cancer. 9: 563-75. PMID 19629071 DOI: 10.1038/nrc2676  0.44
2009 Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, Vera DR, Shaw RJ. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proceedings of the National Academy of Sciences of the United States of America. 106: 11137-42. PMID 19541609 DOI: 10.1073/pnas.0900465106  0.44
2009 Mair W, Panowski SH, Shaw RJ, Dillin A. Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. Plos One. 4: e4535. PMID 19229346 DOI: 10.1371/journal.pone.0004535  0.44
2008 Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. AMPK and PPARdelta agonists are exercise mimetics. Cell. 134: 405-15. PMID 18674809 DOI: 10.1016/j.cell.2008.06.051  0.44
2008 Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Molecular Cell. 30: 214-26. PMID 18439900 DOI: 10.1016/j.molcel.2008.03.003  0.44
2006 Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, ... ... Shaw RJ, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 444: 337-42. PMID 17086191 DOI: 10.1038/nature05354  0.44
2006 Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth Nature. 441: 424-430. PMID 16724053 DOI: 10.1038/nature04869  0.44
2005 Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (New York, N.Y.). 310: 1642-6. PMID 16308421 DOI: 10.1126/science.1120781  0.44
2005 Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. The Journal of Biological Chemistry. 280: 15158-64. PMID 15713674 DOI: 10.1074/jbc.M412065200  0.44
2004 Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 6: 91-9. PMID 15261145 DOI: 10.1016/j.ccr.2004.06.007  0.44
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