| Year |
Citation |
Score |
| 2023 |
Xu G, Chen J, Lu B, Sethupathy P, Qian WJ, Shalev A. Verapamil prevents decline of IGF-1 in subjects with T1D and promotes beta-cell IGF-1 signaling. Diabetes. PMID 37494660 DOI: 10.2337/db23-0256 |
0.424 |
|
| 2022 |
Lu B, Chen J, Xu G, Grayson TB, Jing G, Jo S, Shalev A. Alpha cell TXNIP deletion improves diabetes-associated hyperglycemia and hyperglucagonemia. Endocrinology. PMID 35957590 DOI: 10.1210/endocr/bqac133 |
0.409 |
|
| 2022 |
Xu G, Chen J, Jo SH, Grayson TB, Ramanadham S, Koizumi A, Germain-Lee EL, Lee SJ, Shalev A. Deletion of Gdf15 reduces ER stress-induced beta cell apoptosis and diabetes. Endocrinology. PMID 35290443 DOI: 10.1210/endocr/bqac030 |
0.345 |
|
| 2022 |
Xu G, Grimes TD, Grayson TB, Chen J, Thielen LA, Tse HM, Li P, Kanke M, Lin TT, Schepmoes AA, Swensen AC, Petyuk VA, Ovalle F, Sethupathy P, Qian WJ, ... Shalev A, et al. Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes. Nature Communications. 13: 1159. PMID 35241690 DOI: 10.1038/s41467-022-28826-3 |
0.339 |
|
| 2020 |
Thielen LA, Chen J, Jing G, Moukha-Chafiq O, Xu G, Jo S, Grayson TB, Lu B, Li P, Augelli-Szafran CE, Suto MJ, Kanke M, Sethupathy P, Kim JK, Shalev A. Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. Cell Metabolism. PMID 32726606 DOI: 10.1016/J.Cmet.2020.07.002 |
0.477 |
|
| 2020 |
Xu G, Jo S, Chen J, Grayson T, Shalev A. 50-OR: Beta Cell GDF15 Contributes to Diabetic Stress-Induced Beta-Cell Loss Diabetes. 69. DOI: 10.2337/Db20-50-Or |
0.454 |
|
| 2020 |
Jo S, Xu G, Jing G, Shalev A. 2304-PUB: Increased Glucagon Expression in Diabetes: The Role of miR-320a Diabetes. 69. DOI: 10.2337/Db20-2304-Pub |
0.353 |
|
| 2019 |
Xu G, Thielen LA, Chen J, Grayson TB, Grimes T, Bridges SL, Tse HM, Smith B, Patel R, Li P, Evans-Molina C, Ovalle F, Shalev A. Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss. American Journal of Physiology. Endocrinology and Metabolism. PMID 31408375 DOI: 10.1152/Ajpendo.00122.2019 |
0.423 |
|
| 2018 |
Ovalle F, Grimes T, Xu G, Patel AJ, Grayson TB, Thielen LA, Li P, Shalev A. Verapamil and beta cell function in adults with recent-onset type 1 diabetes. Nature Medicine. PMID 29988125 DOI: 10.1038/S41591-018-0089-4 |
0.49 |
|
| 2018 |
Thielen L, Shalev A. Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP. Current Opinion in Endocrinology, Diabetes and Obesity. 25: 75-80. PMID 29356688 DOI: 10.1097/Med.0000000000000391 |
0.385 |
|
| 2018 |
Thielen L, Chen J, Xu G, Jing G, Grayson T, Jo S, Shalev A. Novel Small Molecule TXNIP Inhibitor Protects Against Diabetes Diabetes. 67. DOI: 10.2337/Db18-87-Or |
0.491 |
|
| 2018 |
Jing G, Chen J, Xu G, Shalev A. Mir-128 Targets Thioredoxin-Interacting Protein 3’UTR and Downregulates Its Expression in Pancreatic Beta Cells Diabetes. 67. DOI: 10.2337/Db18-80-Or |
0.456 |
|
| 2018 |
Jo S, Chen J, Xu G, Grayson T, Thielen L, Shalev A. miR-204 Antagomir Enhances GLP-1 Receptor Function and Glucose Control Diabetes. 67. DOI: 10.2337/Db18-2149-P |
0.465 |
|
| 2018 |
Xu G, Thielen L, Chen J, Jo S, Shalev A. GDF15 Is Induced by T1D-Associated Cytokines and ER Stress and Promotes Beta-Cell Apoptosis Diabetes. 67. DOI: 10.2337/Db18-2109-P |
0.433 |
|
| 2017 |
Hwang PTJ, Shah DK, Garcia JA, Alexander GC, Lim DJ, Cui W, Cooper DK, Shalev A, Kin T, Kim JA, Jun HW. Encapsulation of Human Islets Using a Biomimetic Self-Assembled Nanomatrix Gel for Protection against Cellular Inflammatory Responses. Acs Biomaterials Science & Engineering. 3: 2110-2119. PMID 31289747 DOI: 10.1021/Acsbiomaterials.7B00261 |
0.392 |
|
| 2017 |
Jo S, Chen J, Xu G, Grayson TB, Thielen LA, Shalev A. Mir-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function. Diabetes. PMID 29101219 DOI: 10.2337/Db17-0506 |
0.503 |
|
| 2016 |
Jing G, Chen J, Xu G, Shalev A. Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop. Molecular Metabolism. 5: 1208-1215. PMID 27900263 DOI: 10.1016/J.Molmet.2016.09.010 |
0.494 |
|
| 2016 |
Xu G, Chen J, Jing G, Grayson TB, Shalev A. MiR-204 targets PERK and regulates UPR signaling and beta cell apoptosis. Molecular Endocrinology (Baltimore, Md.). me20161056. PMID 27384111 DOI: 10.1210/Me.2016-1056 |
0.402 |
|
| 2016 |
Chen J, Young ME, Chatham JC, Crossman DK, Dell'Italia LJ, Shalev A. TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00151.2016. PMID 27199118 DOI: 10.1152/Ajpheart.00151.2016 |
0.373 |
|
| 2016 |
Hong K, Xu G, Grayson TB, Shalev A. Cytokines Regulate β-Cell TXNIP via Distinct Mechanisms and Pathways. The Journal of Biological Chemistry. PMID 26858253 DOI: 10.1074/Jbc.M115.698365 |
0.397 |
|
| 2016 |
Khodneva Y, Shalev A, Frank SJ, Carson AP, Safford MM. Calcium channel blocker use is associated with lower fasting serum glucose among adults with diabetes from the REGARDS study. Diabetes Research and Clinical Practice. PMID 26818894 DOI: 10.1016/J.Diabres.2016.01.021 |
0.388 |
|
| 2015 |
Peliciari-Garcia RA, Goel M, Aristorenas JA, Shah K, He L, Yang Q, Shalev A, Bailey SM, Prabhu SD, Chatham JC, Gamble KL, Young ME. Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice. Biochimica Et Biophysica Acta. PMID 26721420 DOI: 10.1016/J.Bbalip.2015.12.012 |
0.313 |
|
| 2015 |
Filios SR, Shalev A. β-Cell MicroRNAs: Small but Powerful. Diabetes. 64: 3631-44. PMID 26494215 DOI: 10.2337/Db15-0831 |
0.333 |
|
| 2014 |
Filios SR, Xu G, Chen J, Hong K, Jing G, Shalev A. MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cell apoptosis. The Journal of Biological Chemistry. 289: 36275-83. PMID 25391656 DOI: 10.1074/Jbc.M114.592360 |
0.44 |
|
| 2014 |
Shalev A. Minireview: Thioredoxin-interacting protein: regulation and function in the pancreatic β-cell. Molecular Endocrinology (Baltimore, Md.). 28: 1211-20. PMID 24911120 DOI: 10.1210/Me.2014-1095 |
0.425 |
|
| 2014 |
Lim DJ, Andukuri A, Vines JB, Rahman SM, Hwang PT, Kim J, Shalev A, Corbett JA, Jun HW. Enhanced MIN-6 beta cell survival and function on a nitric oxide-releasing peptide amphiphile nanomatrix. International Journal of Nanomedicine. 9: 13-21. PMID 24872700 DOI: 10.2147/Ijn.S50873 |
0.341 |
|
| 2014 |
Chen J, Jing G, Xu G, Shalev A. Thioredoxin-interacting protein stimulates its own expression via a positive feedback loop. Molecular Endocrinology (Baltimore, Md.). 28: 674-80. PMID 24628418 DOI: 10.1210/Me.2014-1041 |
0.485 |
|
| 2014 |
Jing G, Westwell-Roper C, Chen J, Xu G, Verchere CB, Shalev A. Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2. The Journal of Biological Chemistry. 289: 11807-15. PMID 24627476 DOI: 10.1074/Jbc.M113.525022 |
0.486 |
|
| 2013 |
Xu G, Chen J, Jing G, Shalev A. Thioredoxin-interacting protein regulates insulin transcription through microRNA-204. Nature Medicine. 19: 1141-6. PMID 23975026 DOI: 10.1038/Nm.3287 |
0.486 |
|
| 2013 |
Kibbe C, Chen J, Xu G, Jing G, Shalev A. FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells. The Journal of Biological Chemistry. 288: 23194-202. PMID 23803610 DOI: 10.1074/Jbc.M113.473082 |
0.451 |
|
| 2012 |
Cha-Molstad H, Xu G, Chen J, Jing G, Young ME, Chatham JC, Shalev A. Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes. Molecular Pharmacology. 82: 541-9. PMID 22734068 DOI: 10.1124/Mol.112.078253 |
0.332 |
|
| 2012 |
Xu G, Chen J, Jing G, Shalev A. Preventing β-cell loss and diabetes with calcium channel blockers. Diabetes. 61: 848-56. PMID 22442301 DOI: 10.2337/Db11-0955 |
0.453 |
|
| 2010 |
Saxena G, Chen J, Shalev A. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. The Journal of Biological Chemistry. 285: 3997-4005. PMID 19959470 DOI: 10.1074/Jbc.M109.034421 |
0.418 |
|
| 2010 |
Chen J, Fontes G, Saxena G, Poitout V, Shalev A. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes. 59: 440-7. PMID 19875615 DOI: 10.2337/Db09-0949 |
0.426 |
|
| 2009 |
Cha-Molstad H, Saxena G, Chen J, Shalev A. Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells. The Journal of Biological Chemistry. 284: 16898-905. PMID 19411249 DOI: 10.1074/Jbc.M109.010504 |
0.484 |
|
| 2009 |
Chen J, Cha-Molstad H, Szabo A, Shalev A. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. American Journal of Physiology. Endocrinology and Metabolism. 296: E1133-9. PMID 19258488 DOI: 10.1152/Ajpendo.90944.2008 |
0.409 |
|
| 2008 |
Shalev A. Lack of TXNIP protects beta-cells against glucotoxicity. Biochemical Society Transactions. 36: 963-5. PMID 18793170 DOI: 10.1042/Bst0360963 |
0.48 |
|
| 2008 |
Chen J, Hui ST, Couto FM, Mungrue IN, Davis DB, Attie AD, Lusis AJ, Davis RA, Shalev A. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3581-94. PMID 18552236 DOI: 10.1096/Fj.08-111690 |
0.463 |
|
| 2008 |
Carper MJ, Cade WT, Cam M, Zhang S, Shalev A, Yarasheski KE, Ramanadham S. HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus. American Journal of Physiology. Endocrinology and Metabolism. 294: E558-67. PMID 18171911 DOI: 10.1152/Ajpendo.00167.2007 |
0.384 |
|
| 2008 |
Chen J, Saxena G, Mungrue IN, Lusis AJ, Shalev A. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes. 57: 938-44. PMID 18171713 DOI: 10.2337/Db07-0715 |
0.473 |
|
| 2007 |
Couto FM, Minn AH, Pise-Masison CA, Radonovich M, Brady JN, Hanson M, Fernandez LA, Wang P, Kendziorski C, Shalev A. Exenatide blocks JAK1-STAT1 in pancreatic beta cells. Metabolism: Clinical and Experimental. 56: 915-8. PMID 17570252 DOI: 10.1016/J.Metabol.2007.02.004 |
0.464 |
|
| 2007 |
Wicksteed B, Uchizono Y, Alarcon C, McCuaig JF, Shalev A, Rhodes CJ. A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation. Cell Metabolism. 5: 221-7. PMID 17339029 DOI: 10.1016/J.Cmet.2007.02.007 |
0.408 |
|
| 2006 |
Cheng DW, Jiang Y, Shalev A, Kowluru R, Crook ED, Singh LP. An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells. Archives of Physiology and Biochemistry. 112: 189-218. PMID 17178593 DOI: 10.1080/13813450601093518 |
0.392 |
|
| 2006 |
Schulze PC, Liu H, Choe E, Yoshioka J, Shalev A, Bloch KD, Lee RT. Nitric oxide-dependent suppression of thioredoxin-interacting protein expression enhances thioredoxin activity. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2666-72. PMID 17023680 DOI: 10.1161/01.Atv.0000248914.21018.F1 |
0.302 |
|
| 2006 |
Minn AH, Couto FM, Shalev A. Metabolism-independent sugar effects on gene transcription: the role of 3-O-methylglucose. Biochemistry. 45: 11047-51. PMID 16964965 DOI: 10.1021/Bi0603625 |
0.431 |
|
| 2006 |
Chen J, Couto FM, Minn AH, Shalev A. Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein. Biochemical and Biophysical Research Communications. 346: 1067-74. PMID 16782054 DOI: 10.1016/J.Bbrc.2006.06.027 |
0.46 |
|
| 2005 |
Minn AH, Pise-Masison CA, Radonovich M, Brady JN, Wang P, Kendziorski C, Shalev A. Gene expression profiling in INS-1 cells overexpressing thioredoxin-interacting protein. Biochemical and Biophysical Research Communications. 336: 770-8. PMID 16143294 DOI: 10.1016/J.Bbrc.2005.08.161 |
0.453 |
|
| 2005 |
Minn AH, Hafele C, Shalev A. Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. Endocrinology. 146: 2397-405. PMID 15705778 DOI: 10.1210/En.2004-1378 |
0.527 |
|
| 2005 |
Minn AH, Lan H, Rabaglia ME, Harlan DM, Peculis BA, Attie AD, Shalev A. Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance. Molecular Endocrinology (Baltimore, Md.). 19: 794-803. PMID 15550470 DOI: 10.1210/Me.2004-0119 |
0.474 |
|
| 2004 |
Minn AH, Kayton M, Lorang D, Hoffmann SC, Harlan DM, Libutti SK, Shalev A. Insulinomas and expression of an insulin splice variant. Lancet (London, England). 363: 363-7. PMID 15070567 DOI: 10.1016/S0140-6736(04)15438-X |
0.459 |
|
| 2004 |
Shalev A, Patterson NB, Hirshberg B, Rother KI, Harlan DM. Resistin serum levels in type 1 diabetes pre- and post-islet transplantation. Metabolism: Clinical and Experimental. 53: 403-4. PMID 15045683 DOI: 10.1016/J.Metabol.2003.11.014 |
0.365 |
|
| 2003 |
Kayton ML, Costouros NG, Lorang D, Alexander HR, Hewitt SM, Cochran C, Shalev A, Harlan D, Skarulis MC, Gorden P, Libutti SK. Peak stimulated insulin secretion is associated with specific changes in gene expression profiles in sporadic insulinomas. Surgery. 134: 982-7; discussion 98. PMID 14668731 DOI: 10.1016/J.Surg.2003.07.011 |
0.396 |
|
| 2003 |
Minn AH, Patterson NB, Pack S, Hoffmann SC, Gavrilova O, Vinson C, Harlan DM, Shalev A. Resistin is expressed in pancreatic islets. Biochemical and Biophysical Research Communications. 310: 641-5. PMID 14521959 DOI: 10.1016/J.Bbrc.2003.09.061 |
0.446 |
|
| 2003 |
Shalev A, Holst JJ, Keller U. Effects of glucagon-like peptide 1 (7-36 amide) on whole-body protein metabolism in healthy man. European Journal of Clinical Investigation. 27: 10-16. PMID 9041371 DOI: 10.1046/J.1365-2362.1997.540613.X |
0.402 |
|
| 2002 |
Shalev A, Pise-Masison CA, Radonovich M, Hoffmann SC, Hirshberg B, Brady JN, Harlan DM. Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway. Endocrinology. 143: 3695-8. PMID 12193586 DOI: 10.1210/En.2002-220564 |
0.478 |
|
| 2002 |
Shalev A, Blair PJ, Hoffmann SC, Hirshberg B, Peculis BA, Harlan DM. A proinsulin gene splice variant with increased translation efficiency is expressed in human pancreatic islets. Endocrinology. 143: 2541-7. PMID 12072386 DOI: 10.1210/Endo.143.7.8920 |
0.422 |
|
| 2001 |
Shalev A, Valášek L, Pise-Masison CA, Radonovich M, Phan L, Clayton J, He H, Brady JN, Hinnebusch AG, Asano K. Saccharomyces cerevisiae Protein Pci8p and Human Protein eIF3e/Int-6 Interact with the eIF3 Core Complex by Binding to Cognate eIF3b Subunits Journal of Biological Chemistry. 276: 34948-34957. DOI: 10.1074/Jbc.M102161200 |
0.32 |
|
| 1999 |
Shalev A. Hope for insulin mimetic oral antidiabetic drugs. European Journal of Endocrinology. 141: 561-562. PMID 10601956 DOI: 10.1530/Eje.0.1410561 |
0.433 |
|
| 1999 |
Shalev A. The crucial role of a phosphatase in insulin resistance and obesity. European Journal of Endocrinology. 141: 323-324. PMID 10526242 DOI: 10.1530/Eje.0.1410323 |
0.368 |
|
| 1998 |
Shalev A. Insulin receptor substrate-2 - a new candidate gene for NIDDM? European Journal of Endocrinology. 139: 263-264. PMID 9758433 DOI: 10.1530/Eje.0.1390263 |
0.354 |
|
| 1998 |
Shalev A, Ninnis R, Keller U. Effects of glucagon-like peptide 1 (7-36 amide) on glucose kinetics during somatostatin-induced suppression of insulin secretion in healthy men Hormone Research in Paediatrics. 49: 221-225. PMID 9568806 DOI: 10.1159/000023175 |
0.429 |
|
| 1997 |
Shalev A. The role of glucagon-like peptide 1 in the regulation of glucose homeostasis and satiety European Journal of Endocrinology. 137: 220-221. PMID 9330582 DOI: 10.1530/Eje.0.1370220 |
0.492 |
|
| 1997 |
Shalev A, Vosmeer S, Keller U. Absence of short-term effects of glucagon-like peptide-1 and of hyperglycemia on plasma leptin levels in man. Metabolism-Clinical and Experimental. 46: 723-725. PMID 9225821 DOI: 10.1016/S0026-0495(97)90112-8 |
0.361 |
|
| 1996 |
Shalev A, Siegrist-Kaiser CA, Yen PM, Wahli W, Burger AG, Chin WW, Meier CA. The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. Endocrinology. 137: 4499-502. PMID 8828512 DOI: 10.1210/Endo.137.10.8828512 |
0.401 |
|
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