| Year |
Citation |
Score |
| 2020 |
Saponaro F, Sestito S, Runfola M, Rapposelli S, Chiellini G. Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders. Frontiers in Medicine. 7: 331. PMID 32733906 DOI: 10.3389/Fmed.2020.00331 |
0.439 |
|
| 2020 |
Perra A, Kowalik MA, Cabras L, Runfola M, Sestito S, Migliore C, Giordano S, Chiellini G, Rapposelli S, Columbano A. Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration. Cell Proliferation. e12808. PMID 32347601 DOI: 10.1111/Cpr.12808 |
0.477 |
|
| 2020 |
Rutigliano G, Bandini L, Sestito S, Chiellini G. 3-Iodothyronamine and Derivatives: New Allies Against Metabolic Syndrome? International Journal of Molecular Sciences. 21. PMID 32183490 DOI: 10.3390/Ijms21062005 |
0.346 |
|
| 2020 |
Bellusci L, Runfola M, Carnicelli V, Sestito S, Fulceri F, Santucci F, Lenzi P, Fornai F, Rapposelli S, Origlia N, Zucchi R, Chiellini G. Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6. Molecules (Basel, Switzerland). 25. PMID 32110992 DOI: 10.3390/Molecules25051054 |
0.322 |
|
| 2019 |
Runfola M, Sestito S, Bellusci L, La Pietra V, D'Amore VM, Kowalik MA, Chiellini G, Gul S, Perra A, Columbano A, Marinelli L, Novellino E, Rapposelli S. Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis. European Journal of Medicinal Chemistry. 188: 112006. PMID 31931337 DOI: 10.1016/J.Ejmech.2019.112006 |
0.424 |
|
| 2019 |
Rogowski M, Bellusci L, Sabatini M, Rapposelli S, Rahman SM, Chiellini G, Assadi-Porter FM. Lipolytic Effects of 3-Iodothyronamine (T1AM) and a Novel Thyronamine-Like Analog SG-2 through the AMPK Pathway. International Journal of Molecular Sciences. 20. PMID 31434215 DOI: 10.3390/Ijms20164054 |
0.33 |
|
| 2019 |
Laurino A, Landucci E, Cinci L, Gencarelli M, De Siena G, Bellusci L, Chiellini G, Raimondi L. Brain Histamine Modulates the Antidepressant-Like Effect of the 3-Iodothyroacetic Acid (TA1). Frontiers in Cellular Neuroscience. 13: 176. PMID 31133807 DOI: 10.3389/Fncel.2019.00176 |
0.308 |
|
| 2019 |
Sestito S, Daniele S, Pietrobono D, Citi V, Bellusci L, Chiellini G, Calderone V, Martini C, Rapposelli S. Memantine prodrug as a new agent for Alzheimer's Disease. Scientific Reports. 9: 4612. PMID 30874573 DOI: 10.1038/S41598-019-40925-8 |
0.301 |
|
| 2017 |
Bellusci L, Laurino A, Sabatini M, Sestito S, Lenzi P, Raimondi L, Rapposelli S, Biagioni F, Fornai F, Salvetti A, Rossi L, Zucchi R, Chiellini G. New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection. Frontiers in Pharmacology. 8: 905. PMID 29311919 DOI: 10.3389/Fphar.2017.00905 |
0.357 |
|
| 2017 |
Columbano A, Chiellini G, Kowalik MA. GC-1: a thyromimetic with multiple therapeutic applications in liver disease. Gene Expression. PMID 28635586 DOI: 10.3727/105221617X14968563796227 |
0.372 |
|
| 2017 |
Accorroni A, Chiellini G, Origlia N. Effects of thyroid hormones and their metabolites on learning and memory in normal and pathological conditions. Current Drug Metabolism. PMID 28093992 DOI: 10.2174/1389200218666170116112407 |
0.372 |
|
| 2017 |
Selen Alpergin ES, Bolandnazar Z, Sabatini M, Rogowski M, Chiellini G, Zucchi R, Assadi-Porter FM. Metabolic profiling reveals reprogramming of lipid metabolic pathways in treatment of polycystic ovary syndrome with 3-iodothyronamine. Physiological Reports. 5. PMID 28082426 DOI: 10.14814/Phy2.13097 |
0.342 |
|
| 2017 |
Chiellini G, Bellusci L, Sabatini M, Zucchi R. Thyronamines and analogues - Translational research on thyronergic amines - The route from rediscovery of thyronamines to the bedside. Molecular and Cellular Endocrinology. PMID 28069535 DOI: 10.1016/J.Mce.2017.01.002 |
0.456 |
|
| 2016 |
Chiellini G, Nesi G, Sestito S, Chiarugi S, Runfola M, Espinoza S, Sabatini M, Bellusci L, Laurino A, Cichero E, Gainetdinov RR, Fossa P, Raimondi L, Zucchi R, Rapposelli S. Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study. Journal of Medicinal Chemistry. PMID 27731647 DOI: 10.1021/Acs.Jmedchem.6B01092 |
0.429 |
|
| 2015 |
Chiellini G, Nesi G, Digiacomo M, Malvasi R, Espinoza S, Sabatini M, Frascarelli S, Laurino A, Cichero E, Macchia M, Gainetdinov RR, Fossa P, Raimondi L, Zucchi R, Rapposelli S. Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists. Journal of Medicinal Chemistry. 58: 5096-107. PMID 26010728 DOI: 10.1021/Acs.Jmedchem.5B00526 |
0.407 |
|
| 2014 |
Mariotti V, Melissari E, Iofrida C, Righi M, Di Russo M, Donzelli R, Saba A, Frascarelli S, Chiellini G, Zucchi R, Pellegrini S. Modulation of gene expression by 3-iodothyronamine: genetic evidence for a lipolytic pattern. Plos One. 9: e106923. PMID 25379707 DOI: 10.1371/Journal.Pone.0106923 |
0.349 |
|
| 2014 |
Zucchi R, Accorroni A, Chiellini G. Update on 3-iodothyronamine and its neurological and metabolic actions. Frontiers in Physiology. 5: 402. PMID 25360120 DOI: 10.3389/Fphys.2014.00402 |
0.469 |
|
| 2014 |
Ghelardoni S, Chiellini G, Frascarelli S, Saba A, Zucchi R. Uptake and metabolic effects of 3-iodothyronamine in hepatocytes. The Journal of Endocrinology. 221: 101-10. PMID 24627446 DOI: 10.1530/Joe-13-0311 |
0.334 |
|
| 2013 |
Haviland JA, Reiland H, Butz DE, Tonelli M, Porter WP, Zucchi R, Scanlan TS, Chiellini G, Assadi-Porter FM. NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T(1)AM treatment. Obesity (Silver Spring, Md.). 21: 2538-44. PMID 23512955 DOI: 10.1002/Oby.20391 |
0.569 |
|
| 2012 |
Chiellini G, Erba P, Carnicelli V, Manfredi C, Frascarelli S, Ghelardoni S, Mariani G, Zucchi R. Distribution of exogenous [ 125I]-3-iodothyronamine in mouse in vivo: Relationship with trace amine-associated receptors Journal of Endocrinology. 213: 223-230. PMID 22442117 DOI: 10.1530/Joe-12-0055 |
0.394 |
|
| 2012 |
Manni ME, De Siena G, Saba A, Marchini M, Dicembrini I, Bigagli E, Cinci L, Lodovici M, Chiellini G, Zucchi R, Raimondi L. 3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice. British Journal of Pharmacology. 166: 650-8. PMID 22225569 DOI: 10.1111/J.1476-5381.2011.01823.X |
0.328 |
|
| 2012 |
Chiellini G, Rapposelli S, Zhu J, Massarelli I, Saraceno M, Bianucci AM, Plum LA, Clagett-Dame M, Deluca HF. Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase Steroids. 77: 212-223. PMID 22133546 DOI: 10.1016/J.Steroids.2011.11.007 |
0.331 |
|
| 2011 |
Frascarelli S, Ghelardoni S, Chiellini G, Galli E, Ronca F, Scanlan TS, Zucchi R. Cardioprotective effect of 3-iodothyronamine in perfused rat heart subjected to ischemia and reperfusion Cardiovascular Drugs and Therapy. 25: 307-313. PMID 21786214 DOI: 10.1007/S10557-011-6320-X |
0.597 |
|
| 2011 |
Venditti P, Napolitano G, Di Stefano L, Chiellini G, Zucchi R, Scanlan TS, Di Meo S. Effects of the thyroid hormone derivatives 3-iodothyronamine and thyronamine on rat liver oxidative capacity Molecular and Cellular Endocrinology. 341: 55-62. PMID 21664427 DOI: 10.1016/J.Mce.2011.05.013 |
0.607 |
|
| 2011 |
Agretti P, de Marco G, Russo L, Saba A, Raffaelli A, Marchini M, Chiellini G, Grasso L, Pinchera A, Vitti P, Scanlan TS, Zucchi R, Tonacchera M. 3-iodothyronamine metabolism and functional effects in FRTL5 thyroid cells Journal of Molecular Endocrinology. 47: 23-32. PMID 21511808 DOI: 10.1530/Jme-10-0168 |
0.596 |
|
| 2010 |
Saba A, Chiellini G, Frascarelli S, Marchini M, Ghelardoni S, Raffaelli A, Tonacchera M, Vitti P, Scanlan TS, Zucchi R. Tissue distribution and cardiac metabolism of 3-iodothyronamine Endocrinology. 151: 5063-5073. PMID 20739399 DOI: 10.1210/En.2010-0491 |
0.596 |
|
| 2010 |
Venditti P, Chiellini G, Di Stefano L, Napolitano G, Zucchi R, Columbano A, Scanlan TS, Di Meo S. The TRβ-selective agonist, GC-1, stimulates mitochondrial oxidative processes to a lesser extent than triiodothyronine Journal of Endocrinology. 205: 279-289. PMID 20360308 DOI: 10.1677/Joe-10-0036 |
0.607 |
|
| 2010 |
Zucchi R, Ghelardoni S, Chiellini G. Cardiac effects of thyronamines. Heart Failure Reviews. 15: 171-6. PMID 19016324 DOI: 10.1007/S10741-008-9120-Z |
0.457 |
|
| 2009 |
Ghelardoni S, Suffredini S, Frascarelli S, Brogioni S, Chiellini G, Ronca-Testoni S, Grandy DK, Scanlan TS, Cerbai E, Zucchi R. Modulation of cardiac ionic homeostasis by 3-iodothyronamine Journal of Cellular and Molecular Medicine. 13: 3082-3090. PMID 19298522 DOI: 10.1111/J.1582-4934.2009.00728.X |
0.574 |
|
| 2009 |
Venditti P, Chiellini G, Bari A, Di Stefano L, Zucchi R, Columbano A, Scanlan TS, Di Meo S. T3 and the thyroid hormone beta-receptor agonist GC-1 differentially affect metabolic capacity and oxidative damage in rat tissues. The Journal of Experimental Biology. 212: 986-93. PMID 19282495 DOI: 10.1242/Jeb.021808 |
0.596 |
|
| 2008 |
Chiellini G, Grzywacz P, Plum LA, Barycki R, Clagett-Dame M, DeLuca HF. Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists. Bioorganic & Medicinal Chemistry. 16: 8563-73. PMID 18722130 DOI: 10.1016/J.Bmc.2008.08.011 |
0.332 |
|
| 2008 |
Frascarelli S, Ghelardoni S, Chiellini G, Vargiu R, Ronca-Testoni S, Scanlan TS, Grandy DK, Zucchi R. Cardiac effects of trace amines: Pharmacological characterization of trace amine-associated receptors European Journal of Pharmacology. 587: 231-236. PMID 18486124 DOI: 10.1016/J.Ejphar.2008.03.055 |
0.59 |
|
| 2008 |
Chiellini G, Ghelardoni S, Frascarelli S, Testoni S, Scanlan TS, Grandy DK, Zucchi R. 3-Iodothyronamine (T1AM) induces variation in phosphorylation pattern of tyrosine residues in rat heart Journal of Molecular and Cellular Cardiology. 44: 773-774. DOI: 10.1016/J.Yjmcc.2008.02.149 |
0.509 |
|
| 2008 |
Frascarelli S, Chiellini G, Ghelardoni S, Ronca-Testoni S, Grandy D, Scanlan T, Zucchi R. Cardioprotection by 3-iodothyronamine, a new endogenous chemical messenger Journal of Molecular and Cellular Cardiology. 44: 773. DOI: 10.1016/J.Yjmcc.2008.02.148 |
0.516 |
|
| 2007 |
Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, DeBarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. Cardiac effects of 3-iodothyronamine: A new aminergic system modulating cardiac function Faseb Journal. 21: 1597-1608. PMID 17284482 DOI: 10.1096/Fj.06-7474Com |
0.579 |
|
| 2007 |
Zucchi R, Chiellini G, Frascarelli S, Carnicelli V, Brogioni S, Ghelardoni S, Testoni S, Grandy DK, Cerbai E, Scanlan TS. Modulation of cardiac inotropic state by 3‐iodothyronamine: evidence for a novel signalling pathway mediated by trace amine‐associated receptors The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A246-D |
0.548 |
|
| 2006 |
Zucchi R, Chiellini G, Scanlan TS, Grandy DK. Trace amine-associated receptors and their ligands British Journal of Pharmacology. 149: 967-978. PMID 17088868 DOI: 10.1038/Sj.Bjp.0706948 |
0.617 |
|
| 2006 |
Columbano A, Pibiri M, Deidda M, Cossu C, Scanlan TS, Chiellini G, Muntoni S, Ledda-Columbano GM. The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas Endocrinology. 147: 3211-3218. PMID 16574785 DOI: 10.1210/En.2005-1561 |
0.641 |
|
| 2006 |
Chiellini G, Ghelardoni S, Frascarelli S, Carnicelli V, Hart M, Ronca-Testoni S, Scanlan TS, Zucchi R. Stimulation of cardiac trace amine receptors by 3-iodothyronamine modulates tyrosine phosphorylation and induces cardioprotection Journal of Molecular and Cellular Cardiology. 40: 962. DOI: 10.1016/J.Yjmcc.2006.03.130 |
0.56 |
|
| 2006 |
Brogioni S, Chiellini G, Hart M, Scanlan TS, Cerbai E, Zucchi R. 3-Iodothyronamine affects calcium handling in isolated cardiomyocytes Journal of Molecular and Cellular Cardiology. 40: 925. DOI: 10.1016/j.yjmcc.2006.03.029 |
0.423 |
|
| 2005 |
Gloss B, Giannocco G, Swanson EA, Moriscot AS, Chiellini G, Scanlan T, Baxter JD, Dillmann WH. Different configurations of specific thyroid hormone response elements mediate opposite effects of thyroid hormone and GC-1 on gene expression Endocrinology. 146: 4926-4933. PMID 16081636 DOI: 10.1210/En.2005-0631 |
0.578 |
|
| 2004 |
Mishra MK, Wilson FE, Scanlan TS, Chiellini G. Thyroid hormone-dependent seasonality in American tree sparrows (Spizella arborea): Effects of GC-1, a thyroid receptor β-selective agonist, and of iopanoic acid, a deiodinase inhibitor Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology. 174: 471-479. PMID 15235810 DOI: 10.1007/s00360-004-0433-5 |
0.52 |
|
| 2004 |
Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin ET, Hatton D, Zucchi R, Grandy DK. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone Nature Medicine. 10: 638-642. PMID 15146179 DOI: 10.1038/Nm1051 |
0.631 |
|
| 2004 |
Furlow JD, Yang HY, Hsu M, Lim W, Ermio DJ, Chiellini G, Scanlan TS. Induction of Larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1 Journal of Biological Chemistry. 279: 26555-26562. PMID 15056670 DOI: 10.1074/Jbc.M402847200 |
0.622 |
|
| 2004 |
Grover GJ, Egan DM, Sleph PG, Beehler BC, Chiellini G, Nguyen NH, Baxter JD, Scanlan TS. Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: Selective actions relative to 3,5,3′-triiodo-L-thyronine Endocrinology. 145: 1656-1661. PMID 14701670 DOI: 10.1210/En.2003-0973 |
0.684 |
|
| 2003 |
Borngraeber S, Budny MJ, Chiellini G, Cunha-Lima ST, Togashi M, Webb P, Baxter JD, Scanlan TS, Fletterick RJ. Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proceedings of the National Academy of Sciences of the United States of America. 100: 15358-63. PMID 14673100 DOI: 10.1073/Pnas.2136689100 |
0.624 |
|
| 2002 |
Webb P, Nguyen NH, Chiellini G, Yoshihara HA, Cunha Lima ST, Apriletti JW, Ribeiro RC, Marimuthu A, West BL, Goede P, Mellstrom K, Nilsson S, Kushner PJ, Fletterick RJ, Scanlan TS, et al. Design of thyroid hormone receptor antagonists from first principles. The Journal of Steroid Biochemistry and Molecular Biology. 83: 59-73. PMID 12650702 DOI: 10.1016/S0960-0760(02)00270-4 |
0.761 |
|
| 2002 |
Chiellini G, Nguyen NH, Apriletti JW, Baxter JD, Scanlan TS. Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorganic & Medicinal Chemistry. 10: 333-46. PMID 11741782 DOI: 10.1016/S0968-0896(01)00284-X |
0.731 |
|
| 2001 |
Scanlan TS, Yoshihara HA, Nguyen NH, Chiellini G. Selective thyromimetics: tissue-selective thyroid hormone analogs. Current Opinion in Drug Discovery & Development. 4: 614-22. PMID 12825456 |
0.782 |
|
| 2001 |
Ribeiro MO, Carvalho SD, Schultz JJ, Chiellini G, Scanlan TS, Bianco AC, Brent GA. Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific. The Journal of Clinical Investigation. 108: 97-105. PMID 11435461 DOI: 10.1172/JCI12584 |
0.594 |
|
| 2001 |
Ribeiro MO, Carvalho SD, Schultz JJ, Chiellini G, Scanlan TS, Bianco AC, Brent GA. Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific Journal of Clinical Investigation. 108: 97-105. DOI: 10.1172/Jci200112584 |
0.431 |
|
| 2000 |
Trost SU, Swanson E, Gloss B, Wang-Iverson DB, Zhang H, Volodarsky T, Grover GJ, Baxter JD, Chiellini G, Scanlan TS, Dillmann WH. The Thyroid Hormone Receptor-β-Selective Agonist GC-1 Differentially Affects Plasma Lipids and Cardiac Activity. Endocrinology. 141: 3057-3064. PMID 28204388 DOI: 10.1210/endo.141.9.7681 |
0.576 |
|
| 2000 |
Chiellini G, Nguyen NH, Yoshihara HA, Scanlan TS. Improved synthesis of the iodine-free thyromimetic GC-1. Bioorganic & Medicinal Chemistry Letters. 10: 2607-11. PMID 11128634 DOI: 10.1016/S0960-894X(00)00531-X |
0.735 |
|
| 2000 |
Trost SU, Swanson E, Gloss B, Wang-Iverson DB, Zhang H, Volodarsky T, Grover GJ, Baxter JD, Chiellini G, Scanlan TS, Dillmann WH. The thyroid hormone receptor-beta-selective agonist GC-1 differentially affects plasma lipids and cardiac activity. Endocrinology. 141: 3057-64. PMID 10965874 DOI: 10.1210/Endo.141.9.7681 |
0.603 |
|
| 1998 |
Yoshihara HA, Chiellini G, Mitchison TJ, Scanlan TS. An efficient substitution reaction for the preparation of thyroid hormone analogues. Bioorganic & Medicinal Chemistry. 6: 1179-83. PMID 9784860 DOI: 10.1016/S0968-0896(98)00085-6 |
0.746 |
|
| 1998 |
Chiellini G, Apriletti JW, Yoshihara HA, Baxter JD, Ribeiro RC, Scanlan TS. A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chemistry & Biology. 5: 299-306. PMID 9653548 DOI: 10.1016/S1074-5521(98)90168-5 |
0.78 |
|
| 1996 |
Balsamo A, Breschi MC, Chiellini G, Cozzini P, Domiano P, Macchia M, Manera C, Martinelli A, Nencetti S, Rossello A, Sacca P, Scatizzi R. Chiral 2-(3′-(5′-p-chlorophenyl)isoxazolidinyl)ethanolamines as conformationally restrained analogs of methyloxyiminomethyl (MOIM) β-adrenergic antagonists: synthesis, configuration and β-adrenergic properties* European Journal of Medicinal Chemistry. 31: 291-300. DOI: 10.1016/0223-5234(96)80366-7 |
0.316 |
|
| 1995 |
Dalpiaz A, Varani K, Borea PA, Martini C, Chiellini G, Lucacchini A. Biochemical and pharmacological characterization of periodate-oxidized adenosine analogues at adenosine A1 receptors Biochimica Et Biophysica Acta. 1267: 145-151. PMID 7612668 DOI: 10.1016/0167-4889(95)00045-T |
0.376 |
|
| 1995 |
Balsamo A, Breschi MC, Chiellini G, Favero L, Macchia M, Martinelli A, Martini C, Rossello A, Scatizzi R. Synthesis and β-adrenergic properties of (E)-N-[3-(alkylamino)-2-hydroxypropylidene](methyloxy)amines substituted with an aromatic group on their [(methyloxy)imino]methyl moiety (MOIMM): an investigation into the biopharmacological effects of an aryl substitution in the class of MOIM β-blocking drugs European Journal of Medicinal Chemistry. 30: 743-755. DOI: 10.1016/0223-5234(96)88293-6 |
0.307 |
|
| 1993 |
Macchia B, Balsamo A, Breschi MC, Chiellini G, Lapucci A, Macchia M, Manera C, Martinelli A, Martini C, Scatizzi R. Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives. Journal of Medicinal Chemistry. 36: 3077-86. PMID 8230093 DOI: 10.1021/Jm00073A006 |
0.31 |
|
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