Christopher E. Pearson - Publications

Affiliations: 
Molecular and Medical Genetics University of Toronto, Toronto, ON, Canada 
Area:
Genetics, Molecular Biology

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shuen AY, Lanni S, Panigrahi GB, Edwards M, Yu L, Campbell BB, Mandel A, Zhang C, Zhukova N, Alharbi M, Bernstein M, Bowers DC, Carroll S, Cole KA, Constantini S, ... ... Pearson CE, et al. Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO1800474. PMID 30608896 DOI: 10.1200/JCO.18.00474  0.6
2018 Zamiri B, Mirceta M, Abu-Ghazalah R, Wold MS, Pearson CE, Macgregor RB. Stress-induced acidification may contribute to formation of unusual structures in C9orf72-repeats. Biochimica Et Biophysica Acta. PMID 29550431 DOI: 10.1016/j.bbagen.2018.03.001  0.56
2017 Alniss H, Zamiri B, Khalaj M, Pearson CE, Macgregor RB. Thermodynamic and spectroscopic investigations of TMPyP4 association with guanine- and cytosine-rich DNA and RNA repeats of C9orf72. Biochemical and Biophysical Research Communications. PMID 29274339 DOI: 10.1016/j.bbrc.2017.12.108  0.56
2017 Ishiguro T, Sato N, Ueyama M, Fujikake N, Sellier C, Kanegami A, Tokuda E, Zamiri B, Gall-Duncan T, Mirceta M, Furukawa Y, Yokota T, Wada K, Taylor JP, Pearson CE, et al. Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31. Neuron. PMID 28343865 DOI: 10.1016/j.neuron.2017.02.046  0.56
2017 Barbé L, Lanni S, López-Castel A, Franck S, Spits C, Keymolen K, Seneca S, Tomé S, Miron I, Letourneau J, Liang M, Choufani S, Weksberg R, Wilson MD, Sedlacek Z, ... ... Pearson CE, et al. CpG Methylation, a Parent-of-Origin Effect for Maternal-Biased Transmission of Congenital Myotonic Dystrophy. American Journal of Human Genetics. 100: 488-505. PMID 28257691 DOI: 10.1016/j.ajhg.2017.01.033  0.48
2016 Slean MM, Panigrahi GB, Castel AL, Pearson AB, Tomkinson AE, Pearson CE. Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks. Dna Repair. PMID 27155933 DOI: 10.1016/j.dnarep.2016.04.002  0.6
2015 Schmidt MH, Pearson CE. Disease-associated repeat instability and mismatch repair. Dna Repair. PMID 26774442 DOI: 10.1016/j.dnarep.2015.11.008  0.56
2015 Kansal R, Li X, Shen J, Samuel D, Laningham F, Lee H, Panigrahi GB, Shuen A, Kantarci S, Dorrani N, Reiss J, Shintaku P, Deignan JL, Strom SP, Pearson CE, et al. An infant with MLH3 variants, FOXG1-duplication and multiple, benign cranial and spinal tumors: A clinical exome sequencing study. Genes, Chromosomes & Cancer. PMID 26542077 DOI: 10.1002/gcc.22319  0.56
2015 Zamiri B, Mirceta M, Bomsztyk K, Macgregor RB, Pearson CE. Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation. Nucleic Acids Research. PMID 26432832 DOI: 10.1093/nar/gkv1008  0.56
2015 Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S, Pollett A, Lipman T, Heidari A, Deshmukh S, Avitzur N, ... ... Pearson CE, et al. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers. Nature Genetics. 47: 257-62. PMID 25642631 DOI: 10.1038/ng.3202  0.56
2015 Trang H, Stanley SY, Thorner P, Faghfoury H, Schulze A, Hawkins C, Pearson CE, Yoon G. Massive CAG repeat expansion and somatic instability in maternally transmitted infantile spinocerebellar ataxia type 7. Jama Neurology. 72: 219-23. PMID 25506882 DOI: 10.1001/jamaneurol.2014.1902  0.56
2014 Reddy K, Schmidt MH, Geist JM, Thakkar NP, Panigrahi GB, Wang YH, Pearson CE. Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability. Nucleic Acids Research. 42: 10473-87. PMID 25147206 DOI: 10.1093/nar/gku658  0.56
2014 Martins S, Pearson CE, Coutinho P, Provost S, Amorim A, Dubé MP, Sequeiros J, Rouleau GA. Modifiers of (CAG)(n) instability in Machado-Joseph disease (MJD/SCA3) transmissions: an association study with DNA replication, repair and recombination genes. Human Genetics. 133: 1311-8. PMID 25026993 DOI: 10.1007/s00439-014-1467-8  0.56
2014 Zamiri B, Reddy K, Macgregor RB, Pearson CE. TMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins. The Journal of Biological Chemistry. 289: 4653-9. PMID 24371143 DOI: 10.1074/jbc.C113.502336  0.56
2014 Mason AG, Tomé S, Simard JP, Libby RT, Bammler TK, Beyer RP, Morton AJ, Pearson CE, La Spada AR. Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age. Human Molecular Genetics. 23: 1606-18. PMID 24191263 DOI: 10.1093/hmg/ddt551  0.56
2013 Axford MM, Wang YH, Nakamori M, Zannis-Hadjopoulos M, Thornton CA, Pearson CE. Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues. Plos Genetics. 9: e1003866. PMID 24367268 DOI: 10.1371/journal.pgen.1003866  0.56
2013 Pinto RM, Dragileva E, Kirby A, Lloret A, Lopez E, St Claire J, Panigrahi GB, Hou C, Holloway K, Gillis T, Guide JR, Cohen PE, Li GM, Pearson CE, Daly MJ, et al. Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches. Plos Genetics. 9: e1003930. PMID 24204323 DOI: 10.1371/journal.pgen.1003930  0.56
2013 Reddy K, Pearson CE. RAN translation: fragile X in the running. Neuron. 78: 405-8. PMID 23664607 DOI: 10.1016/j.neuron.2013.04.034  1
2013 Tomé S, Manley K, Simard JP, Clark GW, Slean MM, Swami M, Shelbourne PF, Tillier ER, Monckton DG, Messer A, Pearson CE. MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice. Plos Genetics. 9: e1003280. PMID 23468640 DOI: 10.1371/journal.pgen.1003280  0.56
2013 Axford MM, Pearson CE. Illuminating CNS and cognitive issues in myotonic dystrophy: Workshop report. Neuromuscular Disorders : Nmd. 23: 370-4. PMID 23453858 DOI: 10.1016/j.nmd.2013.01.003  0.6
2013 Reddy K, Zamiri B, Stanley SY, Macgregor RB, Pearson CE. The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures. The Journal of Biological Chemistry. 288: 9860-6. PMID 23423380 DOI: 10.1074/jbc.C113.452532  1
2013 Slean MM, Reddy K, Wu B, Nichol Edamura K, Kekis M, Nelissen FH, Aspers RL, Tessari M, Schärer OD, Wijmenga SS, Pearson CE. Interconverting conformations of slipped-DNA junctions formed by trinucleotide repeats affect repair outcome. Biochemistry. 52: 773-85. PMID 23339280 DOI: 10.1021/bi301369b  0.56
2013 Tomé S, Simard JP, Slean MM, Holt I, Morris GE, Wojciechowicz K, te Riele H, Pearson CE. Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. Dna Repair. 12: 46-52. PMID 23228367 DOI: 10.1016/j.dnarep.2012.10.006  0.56
2013 Hick A, Wattenhofer-Donzé M, Chintawar S, Tropel P, Simard JP, Vaucamps N, Gall D, Lambot L, André C, Reutenauer L, Rai M, Teletin M, Messaddeq N, Schiffmann SN, Viville S, ... Pearson CE, et al. Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich's ataxia. Disease Models & Mechanisms. 6: 608-21. PMID 23136396 DOI: 10.1242/dmm.010900  0.4
2012 Pearson CE. Repeat-associated diseases, mutagenesis, pathogenesis, and therapeutic avenues. Rinshō Shinkeigaku = Clinical Neurology. 52: 1023. PMID 23196503 DOI: DN/JST.JSTAGE/clinicalneurol/52.1023  0.56
2012 Panigrahi GB, Slean MM, Simard JP, Pearson CE. Human mismatch repair protein hMutLα is required to repair short slipped-DNAs of trinucleotide repeats. The Journal of Biological Chemistry. 287: 41844-50. PMID 23086927 DOI: 10.1074/jbc.M112.420398  0.6
2012 Rudnicki DD, Margolis RL, Pearson CE, Krzyzosiak WJ. Diced triplets expose neurons to RISC. Plos Genetics. 8: e1002545. PMID 22383898 DOI: 10.1371/journal.pgen.1002545  0.56
2012 Eyries M, Coulet F, Girerd B, Montani D, Humbert M, Lacombe P, Chinet T, Gouya L, Roume J, Axford MM, Pearson CE, Soubrier F. ACVRL1 germinal mosaic with two mutant alleles in hereditary hemorrhagic telangiectasia associated with pulmonary arterial hypertension. Clinical Genetics. 82: 173-9. PMID 21651515 DOI: 10.1111/j.1399-0004.2011.01727.x  0.6
2011 Axford MM, López-Castel A, Nakamori M, Thornton CA, Pearson CE. Replacement of the myotonic dystrophy type 1 CTG repeat with 'non-CTG repeat' insertions in specific tissues. Journal of Medical Genetics. 48: 438-43. PMID 21622935 DOI: 10.1136/jmg.2010.085944  0.6
2011 Tomé S, Panigrahi GB, López Castel A, Foiry L, Melton DW, Gourdon G, Pearson CE. Maternal germline-specific effect of DNA ligase I on CTG/CAG instability. Human Molecular Genetics. 20: 2131-43. PMID 21378394 DOI: 10.1093/hmg/ddr099  0.56
2011 López Castel A, Nakamori M, Thornton CA, Pearson CE. Identification of restriction endonucleases sensitive to 5-cytosine methylation at non-CpG sites, including expanded (CAG)n/(CTG)n repeats. Epigenetics : Official Journal of the Dna Methylation Society. 6: 416-20. PMID 21364324  0.76
2011 Nakamori M, Pearson CE, Thornton CA. Bidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats. Human Molecular Genetics. 20: 580-8. PMID 21088112 DOI: 10.1093/hmg/ddq501  0.48
2011 Reddy K, Tam M, Bowater RP, Barber M, Tomlinson M, Nichol Edamura K, Wang YH, Pearson CE. Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats. Nucleic Acids Research. 39: 1749-62. PMID 21051337 DOI: 10.1093/nar/gkq935  1
2011 López Castel A, Nakamori M, Tomé S, Chitayat D, Gourdon G, Thornton CA, Pearson CE. Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues. Human Molecular Genetics. 20: 1-15. PMID 21044947 DOI: 10.1093/hmg/ddq427  0.76
2011 Seriola A, Spits C, Simard JP, Hilven P, Haentjens P, Pearson CE, Sermon K. Huntington's and myotonic dystrophy hESCs: down-regulated trinucleotide repeat instability and mismatch repair machinery expression upon differentiation. Human Molecular Genetics. 20: 176-85. PMID 20935170 DOI: 10.1093/hmg/ddq456  0.4
2010 Cleary JD, Tomé S, López Castel A, Panigrahi GB, Foiry L, Hagerman KA, Sroka H, Chitayat D, Gourdon G, Pearson CE. Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus. Nature Structural & Molecular Biology. 17: 1079-87. PMID 20711191 DOI: 10.1038/nsmb.1876  0.92
2010 Panigrahi GB, Slean MM, Simard JP, Gileadi O, Pearson CE. Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired. Proceedings of the National Academy of Sciences of the United States of America. 107: 12593-8. PMID 20571119 DOI: 10.1073/pnas.0909087107  0.6
2010 López Castel A, Cleary JD, Pearson CE. Repeat instability as the basis for human diseases and as a potential target for therapy. Nature Reviews. Molecular Cell Biology. 11: 165-70. PMID 20177394 DOI: 10.1038/nrm2854  0.92
2009 López Castel A, Tomkinson AE, Pearson CE. CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair. The Journal of Biological Chemistry. 284: 26631-45. PMID 19628465 DOI: 10.1074/jbc.M109.034405  0.56
2009 Tomé S, Holt I, Edelmann W, Morris GE, Munnich A, Pearson CE, Gourdon G. MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice. Plos Genetics. 5: e1000482. PMID 19436705 DOI: 10.1371/journal.pgen.1000482  0.56
2009 Hagerman KA, Ruan H, Edamura KN, Matsuura T, Pearson CE, Wang YH. The ATTCT repeats of spinocerebellar ataxia type 10 display strong nucleosome assembly which is enhanced by repeat interruptions. Gene. 434: 29-34. PMID 19171184 DOI: 10.1016/j.gene.2008.12.011  0.56
2008 Libby RT, Hagerman KA, Pineda VV, Lau R, Cho DH, Baccam SL, Axford MM, Cleary JD, Moore JM, Sopher BL, Tapscott SJ, Filippova GN, Pearson CE, La Spada AR. CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination. Plos Genetics. 4: e1000257. PMID 19008940 DOI: 10.1371/journal.pgen.1000257  0.56
2008 Slean MM, Panigrahi GB, Ranum LP, Pearson CE. Mutagenic roles of DNA "repair" proteins in antibody diversity and disease-associated trinucleotide repeat instability. Dna Repair. 7: 1135-54. PMID 18485833 DOI: 10.1016/j.dnarep.2008.03.014  0.6
2006 Christodoulou J, Craig HJ, Walker DC, Weaving LS, Pearson CE, McInnes RR. Deletion hotspot in the argininosuccinate lyase gene: association with topoisomerase II and DNA polymerase alpha sites. Human Mutation. 27: 1065-71. PMID 16941645 DOI: 10.1002/humu.20352  0.56
2006 Matsuura T, Fang P, Pearson CE, Jayakar P, Ashizawa T, Roa BB, Nelson DL. Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier? American Journal of Human Genetics. 78: 125-9. PMID 16385455 DOI: 10.1086/498654  0.44
2005 Pearson CE, Nichol Edamura K, Cleary JD. Repeat instability: mechanisms of dynamic mutations. Nature Reviews. Genetics. 6: 729-42. PMID 16205713 DOI: 10.1038/nrg1689  0.92
2005 Panigrahi GB, Lau R, Montgomery SE, Leonard MR, Pearson CE. Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair. Nature Structural & Molecular Biology. 12: 654-62. PMID 16025129 DOI: 10.1038/nsmb959  0.56
2005 Cleary JD, Pearson CE. Replication fork dynamics and dynamic mutations: the fork-shift model of repeat instability. Trends in Genetics : Tig. 21: 272-80. PMID 15851063 DOI: 10.1016/j.tig.2005.03.008  0.92
2005 Nichol Edamura K, Leonard MR, Pearson CE. Role of replication and CpG methylation in fragile X syndrome CGG deletions in primate cells. American Journal of Human Genetics. 76: 302-11. PMID 15625623 DOI: 10.1086/427928  0.68
2005 Mulvihill DJ, Nichol Edamura K, Hagerman KA, Pearson CE, Wang YH. Effect of CAT or AGG interruptions and CpG methylation on nucleosome assembly upon trinucleotide repeats on spinocerebellar ataxia, type 1 and fragile X syndrome. The Journal of Biological Chemistry. 280: 4498-503. PMID 15574425 DOI: 10.1074/jbc.M413239200  0.68
2003 Yang Z, Lau R, Marcadier JL, Chitayat D, Pearson CE. Replication inhibitors modulate instability of an expanded trinucleotide repeat at the myotonic dystrophy type 1 disease locus in human cells. American Journal of Human Genetics. 73: 1092-105. PMID 14574643 DOI: 10.1086/379523  0.48
2003 Tam M, Erin Montgomery S, Kekis M, Stollar BD, Price GB, Pearson CE. Slipped (CTG).(CAG) repeats of the myotonic dystrophy locus: surface probing with anti-DNA antibodies. Journal of Molecular Biology. 332: 585-600. PMID 12963369 DOI: 10.1016/S0022-2836(03)00880-5  0.56
2003 Jin P, Zarnescu DC, Zhang F, Pearson CE, Lucchesi JC, Moses K, Warren ST. RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron. 39: 739-47. PMID 12948442 DOI: 10.1016/S0896-6273(03)00533-6  0.56
2003 Libby RT, Monckton DG, Fu YH, Martinez RA, McAbney JP, Lau R, Einum DD, Nichol K, Ware CB, Ptacek LJ, Pearson CE, La Spada AR. Genomic context drives SCA7 CAG repeat instability, while expressed SCA7 cDNAs are intergenerationally and somatically stable in transgenic mice. Human Molecular Genetics. 12: 41-50. PMID 12490531 DOI: 10.1093/hmg/ddg006  0.56
2002 Pearson CE, Tam M, Wang YH, Montgomery SE, Dar AC, Cleary JD, Nichol K. Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions. Nucleic Acids Research. 30: 4534-47. PMID 12384601  0.92
2002 Nichol K, Pearson CE. CpG methylation modifies the genetic stability of cloned repeat sequences. Genome Research. 12: 1246-56. PMID 12176932 DOI: 10.1101/gr.74502  0.56
2002 Cleary JD, Nichol K, Wang YH, Pearson CE. Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells. Nature Genetics. 31: 37-46. PMID 11967533 DOI: 10.1038/ng870  0.92
2002 Panigrahi GB, Cleary JD, Pearson CE. In vitro (CTG)*(CAG) expansions and deletions by human cell extracts. The Journal of Biological Chemistry. 277: 13926-34. PMID 11832482 DOI: 10.1074/jbc.M109761200  0.92
2002 Novac O, Alvarez D, Pearson CE, Price GB, Zannis-Hadjopoulos M. The human cruciform-binding protein, CBP, is involved in DNA replication and associates in vivo with mammalian replication origins. The Journal of Biological Chemistry. 277: 11174-83. PMID 11805087 DOI: 10.1074/jbc.M107902200  0.56
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