Raphael A. Nemenoff - Publications

Affiliations: 
Pharmacology University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Pharmacology, Molecular Biology, Physiology Biology, Pathology

119 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Johnson AM, Boland JM, Wrobel J, Klezcko EK, Weiser-Evans M, Hopp K, Heasley L, Clambey ET, Jordan K, Nemenoff RA, Schenk EL. Cancer cell-specific MHCII expression as a determinant of the immune infiltrate organization and function in the non-small cell lung cancer tumor microenvironment. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 34048945 DOI: 10.1016/j.jtho.2021.05.004  0.44
2021 Gurule NJ, McCoach CE, Hinz TK, Merrick DT, Van Bokhoven A, Kim J, Patil T, Calhoun J, Nemenoff RA, Tan AC, Doebele RC, Heasley LE. A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer. Npj Precision Oncology. 5: 41. PMID 34001994 DOI: 10.1038/s41698-021-00181-4  0.52
2021 Jolly AJ, Lu S, Strand KA, Dubner AM, Mutryn MF, Nemenoff RA, Majesky MW, Moulton KS, Weiser-Evans MCM. Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodeling. Cardiovascular Research. PMID 33989378 DOI: 10.1093/cvr/cvab174  0.32
2021 Gadwa J, Bickett TE, Darragh LB, Knitz MW, Bhatia S, Piper M, Van Court B, Bhuvane S, Nguyen D, Nangia V, Kleczko EK, Nemenoff RA, Karam SD. Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer. Journal For Immunotherapy of Cancer. 9. PMID 33789881 DOI: 10.1136/jitc-2021-002585  0.44
2021 Korpela SP, Hinz TK, Oweida A, Kim J, Calhoun J, Ferris R, Nemenoff RA, Karam SD, Clambey ET, Heasley LE. Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response. Journal of Translational Medicine. 19: 43. PMID 33485341 DOI: 10.1186/s12967-021-02706-8  0.52
2020 Johnson AM, Kleczko EK, Nemenoff RA. Eicosanoids in Cancer: New Roles in Immunoregulation. Frontiers in Pharmacology. 11: 595498. PMID 33364964 DOI: 10.3389/fphar.2020.595498  0.44
2020 Strand KA, Lu S, Mutryn MF, Li L, Zhou Q, Enyart BT, Jolly AJ, Dubner AM, Moulton KS, Nemenoff RA, Koch KA, LaBarbera D, Weiser-Evans MCM. High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314458. PMID 32580634 DOI: 10.1161/Atvbaha.120.314458  0.32
2020 Laskowski J, Renner B, Pickering MC, Serkova NJ, Smith-Jones PM, Clambey ET, Nemenoff RA, Thurman JM. Complement factor H-deficient mice develop spontaneous hepatic tumors. The Journal of Clinical Investigation. PMID 32369457 DOI: 10.1172/Jci135105  0.4
2020 Neuwelt AJ, Kimball AK, Johnson AM, Arnold BW, Bullock BL, Kaspar RE, Kleczko EK, Kwak JW, Wu MH, Heasley LE, Doebele RC, Li HY, Nemenoff RA, Clambey ET. Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms. Journal For Immunotherapy of Cancer. 8. PMID 32312906 DOI: 10.1136/Jitc-2019-000441  0.52
2020 Brown CN, Atwood DJ, Pokhrel D, Ravichandran K, Holditch SJ, Saxena S, Miyazaki M, Nemenoff R, Weiser-Evans MCM, Ljubanovic DG, Joy MS, Edelstein CL. The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice. Cellular Signalling. 109605. PMID 32194168 DOI: 10.1016/J.Cellsig.2020.109605  0.32
2020 Johnson AM, Bullock BL, Neuwelt AJ, Poczobutt JM, Kaspar RE, Li HY, Kwak JW, Hopp K, Weiser-Evans MCM, Heasley LE, Schenk EL, Clambey ET, Nemenoff RA. Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma. Journal of Immunology (Baltimore, Md. : 1950). PMID 32179637 DOI: 10.4049/Jimmunol.1900778  0.52
2020 Johnson AM, Bulock BL, Neuwelt AJ, Schenk EL, Clambey ET, Nemenoff RA. Abstract A20: Cancer cell-intrinsic expression of MHCII regulates the immune microenvironment and response to immune therapy in lung adenocarcinoma Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm19-A20  0.44
2020 Sisler D, Korpela S, Gurule N, Hinz T, Marek L, Bullock B, Li H, Joshi M, Sempeck C, Nemenoff R, Heasley L. Abstract B51: MAPK regulation of an innate immune response in KRAS-mutant lung adenocarcinoma Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-B51  0.48
2019 Nemenoff RA, Kleczko EK, Hopp K. Renal double negative T cells: unconventional cells in search of a function. Annals of Translational Medicine. 7: S342. PMID 32016060 DOI: 10.21037/Atm.2019.09.107  0.44
2019 Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119313757. PMID 31852223 DOI: 10.1161/Atvbaha.119.313757  0.32
2019 Kleczko EK, Kwak JW, Schenk EL, Nemenoff RA. Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer. Frontiers in Immunology. 10: 954. PMID 31134065 DOI: 10.3389/Fimmu.2019.00954  0.44
2019 Bullock BL, Kimball AK, Poczobutt JM, Neuwelt AJ, Li HY, Johnson AM, Kwak JW, Kleczko EK, Kaspar RE, Wagner EK, Hopp K, Schenk EL, Weiser-Evans MC, Clambey ET, Nemenoff RA. Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC. Life Science Alliance. 2. PMID 31133614 DOI: 10.26508/lsa.201900328  0.44
2019 Sippel TR, Johnson AM, Li HY, Hanson D, Nguyen TT, Bullock BL, Poczobutt JM, Kwak JW, Kleczko EK, Weiser-Evans MC, Nemenoff RA. Activation of PPARγ in Myeloid Cells Promotes Progression of Epithelial Lung Tumors Through TGF-β1. Molecular Cancer Research : McR. PMID 31088909 DOI: 10.1158/1541-7786.Mcr-19-0236  0.44
2019 Oweida AJ, Darragh L, Phan A, Binder D, Bhatia S, Mueller A, Van Court B, Milner D, Raben D, Woessner R, Heasley L, Nemenoff R, Clambey E, Karam SD. The role of regulatory T cells in the response to radiation therapy in head and neck cancer. Journal of the National Cancer Institute. PMID 30863843 DOI: 10.1093/Jnci/Djz036  0.4
2019 Montford JR, Bauer C, Dobrinskikh E, Hopp K, Levi M, Weiser-Evans MC, Nemenoff RA, Furgeson SB. Inhibition of 5-Lipoxygenase Decreases Renal Fibrosis and Progression of Chronic Kidney Disease. American Journal of Physiology. Renal Physiology. PMID 30649890 DOI: 10.1152/Ajprenal.00262.2018  0.32
2018 Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML. Subcellular Localization and Activity of the Mitogen-activated Protein Kinase Kinase 7 (MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin. Molecular Pharmacology. PMID 30404891 DOI: 10.1124/Mol.118.113159  0.52
2018 Kleczko EK, Marsh KH, Tyler LC, Furgeson SB, Bullock BL, Altmann CJ, Miyazaki M, Gitomer BY, Harris PC, Weiser-Evans MCM, Chonchol MB, Clambey ET, Nemenoff RA, Hopp K. CD8 T cells modulate autosomal dominant polycystic kidney disease progression. Kidney International. PMID 30249452 DOI: 10.1016/J.Kint.2018.06.025  0.44
2018 Oweida A, Hararah M, Phan AV, Binder DC, Bhatia S, Lennon S, Bukkapatnam S, Van Court B, Uyanga N, Darragh L, Kim HM, Raben D, Tan AC, Heasley L, Clambey ET, ... Nemenoff RA, et al. Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation and regulatory T-cell infiltration. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30042205 DOI: 10.1158/1078-0432.Ccr-18-1038  0.4
2018 Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, ... ... Nemenoff RA, et al. Altered cell-cycle control, inflammation and adhesion in high-risk persistent bronchial dysplasia. Cancer Research. PMID 29997230 DOI: 10.1158/0008-5472.Can-17-3822  0.4
2018 Li HY, McSharry M, Walker D, Johnson A, Kwak J, Bullock B, Neuwelt A, Poczobutt JM, Sippel TR, Keith RL, Weiser-Evans MCM, Clambey E, Nemenoff RA. Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II. Oncoimmunology. 7: e1423182. PMID 29721380 DOI: 10.1080/2162402X.2017.1423182  0.32
2018 Moulton KS, Li M, Strand K, Burgett S, McClatchey P, Tucker R, Furgeson SB, Lu S, Kirkpatrick B, Cleveland JC, Nemenoff RA, Ambardekar AV, Weiser-Evans MC. PTEN deficiency promotes pathological vascular remodeling of human coronary arteries. Jci Insight. 3. PMID 29467331 DOI: 10.1172/Jci.Insight.97228  0.32
2018 Kimball AK, Oko LM, Bullock BL, Nemenoff RA, van Dyk LF, Clambey ET. A Beginner's Guide to Analyzing and Visualizing Mass Cytometry Data. Journal of Immunology (Baltimore, Md. : 1950). 200: 3-22. PMID 29255085 DOI: 10.4049/Jimmunol.1701494  0.4
2018 Oweida AJ, Hararah M, Phan A, Bhatia S, Lennon S, Binder D, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Abstract 2766: Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation in anti-PD-L1 refractory head and neck cancer Cancer Research. 78: 2766-2766. DOI: 10.1158/1538-7445.Am2018-2766  0.4
2017 Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB. Bone Marrow-Derived cPLA2α Contributes to Renal Fibrosis Progression. Journal of Lipid Research. PMID 29229740 DOI: 10.1194/Jlr.M082362  0.32
2017 Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 6: e1356153. PMID 29123967 DOI: 10.1080/2162402X.2017.1356153  0.4
2017 Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris J, Clambey ET, Thurman JM, Nemenoff RA. Complement activation via a C3a receptor pathway alters CD4+ T lymphocytes and mediates lung cancer progression. Cancer Research. PMID 29118090 DOI: 10.1158/0008-5472.Can-17-0240  0.44
2017 Li HY, McSharry MV, Bullock B, Nguyen TT, Kwak J, Poczobutt JM, Sippel TR, Heasley LE, Weiser-Evans MC, Clambey ET, Nemenoff RA. The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PDL1 Antibody Blockade. Cancer Immunology Research. PMID 28819064 DOI: 10.1158/2326-6066.Cir-16-0365  0.52
2016 Majesky MW, Horita H, Ostriker A, Lu S, Regan JN, Bagchi AK, Dong XR, Poczobutt JM, Nemenoff RA, Weiser-Evans MC. Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by KLF4. Circulation Research. PMID 27834190 DOI: 10.1161/Circresaha.116.309322  0.32
2016 Montford JR, Lehman AM, Scobey MS, Weiser-Evans MC, Nemenoff RA, Furgeson SB. Cytosolic phospholipase A2α increases proliferation and de-differentiation of human renal tubular epithelial cells. Prostaglandins & Other Lipid Mediators. 126: 1-8. PMID 27554058 DOI: 10.1016/J.Prostaglandins.2016.08.001  0.32
2016 Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC. Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nature Communications. 7: 10830. PMID 26940659 DOI: 10.1038/Ncomms10830  0.32
2016 Poczobutt JM, De S, Yadav VK, Nguyen TT, Li H, Sippel TR, Weiser-Evans MC, Nemenoff RA. Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer. Journal of Immunology (Baltimore, Md. : 1950). PMID 26873985 DOI: 10.4049/Jimmunol.1502364  0.52
2016 Li H, McSharry M, Clambey E, Nguyen T, McNamee E, Weiser-Evans M, Nemenoff R. Abstract A122: Non-small cell lung cancer cells induce PD-L1 expression in the tumor microenvironment in an orthotopic mouse model of lung cancer Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A122  0.32
2016 Kwak J, Li H, Laskowski J, Weiser-Evans M, Thurman J, Nemenoff RA. Abstract A121: Complement activation is critical for tumor progression in an orthotopic immunocompetent model of lung cancer Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A121  0.32
2015 Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA. Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. Journal of Immunology (Baltimore, Md. : 1950). PMID 26663781 DOI: 10.4049/Jimmunol.1501648  0.52
2015 Fernandez-Boyanapalli RF, Frasch SC, Thomas SM, Malcolm KC, Nicks M, Harbeck RJ, Jakubzick CV, Nemenoff R, Henson PM, Holland SM, Bratton DL. Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease. The Journal of Allergy and Clinical Immunology. 135: 517-527.e12. PMID 25498313 DOI: 10.1016/J.Jaci.2014.10.034  0.52
2014 Wang CA, Drasin D, Pham C, Jedlicka P, Zaberezhnyy V, Guney M, Li H, Nemenoff R, Costello JC, Tan AC, Ford HL. Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression. Cancer Research. 74: 7357-70. PMID 25348955 DOI: 10.1158/0008-5472.Can-14-0666  0.52
2014 Lehman AM, Montford JR, Horita H, Ostriker AC, Weiser-Evans MC, Nemenoff RA, Furgeson SB. Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells. Molecular Pharmacology. 86: 570-9. PMID 25169989 DOI: 10.1124/Mol.114.092163  0.52
2014 Marek LA, Hinz TK, von Mässenhausen A, Olszewski KA, Kleczko EK, Boehm D, Weiser-Evans MC, Nemenoff RA, Hoffmann H, Warth A, Gozgit JM, Perner S, Heasley LE. Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma. Molecular Cancer Research : McR. 12: 1460-9. PMID 24966347 DOI: 10.1158/1541-7786.Mcr-14-0038  0.52
2014 Ostriker A, Horita HN, Poczobutt J, Weiser-Evans MC, Nemenoff RA. Vascular smooth muscle cell-derived transforming growth factor-β promotes maturation of activated, neointima lesion-like macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 877-86. PMID 24526697 DOI: 10.1161/Atvbaha.114.303214  0.52
2014 Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, ... Nemenoff R, et al. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 40: 66-77. PMID 24412613 DOI: 10.1016/J.Immuni.2013.11.020  0.52
2014 Merrick DT, Edwards MG, Franklin WA, Sugita M, Friedman M, Miller YE, Dwyer-Nield L, Tennis M, Choo K, Hickey G, Adriaan vB, Heasley L, Bunn PA, Geraci M, Keith RL, ... Nemenoff R, et al. Abstract 231: Gene expression analysis of persistent and regressive bronchial dysplasia identifies polo-like kinase 1 (PLK1) and epoxide hydrolase 3 (EPHX3) as potential mediators of malignant progression Cancer Research. 74: 231-231. DOI: 10.1158/1538-7445.Am2014-231  0.4
2013 Poczobutt JM, Gijon M, Amin J, Hanson D, Li H, Walker D, Weiser-Evans M, Lu X, Murphy RC, Nemenoff RA. Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment. Plos One. 8: e79633. PMID 24244531 DOI: 10.1371/Journal.Pone.0079633  0.52
2013 Horita H, Furgeson SB, Ostriker A, Olszewski KA, Sullivan T, Villegas LR, Levine M, Parr JE, Cool CD, Nemenoff RA, Weiser-Evans MC. Selective inactivation of PTEN in smooth muscle cells synergizes with hypoxia to induce severe pulmonary hypertension. Journal of the American Heart Association. 2: e000188. PMID 23727701 DOI: 10.1161/Jaha.113.000188  0.52
2012 Majka SM, Miller HL, Sullivan T, Erickson PF, Kong R, Weiser-Evans M, Nemenoff R, Moldovan R, Morandi SA, Davis JA, Klemm DJ. Adipose lineage specification of bone marrow-derived myeloid cells. Adipocyte. 1: 215-229. PMID 23700536 DOI: 10.4161/adip.21496  0.32
2012 Yu JA, Mauchley D, Li H, Meng X, Nemenoff RA, Fullerton DA, Weyant MJ. Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo The Journal of Thoracic and Cardiovascular Surgery. 144: 1185-1191. PMID 23079010 DOI: 10.1016/J.Jtcvs.2012.08.003  0.52
2012 Yu JA, Li H, Meng X, Fullerton DA, Nemenoff RA, Mitchell JD, Weyant MJ. Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells Journal of Thoracic and Cardiovascular Surgery. 144: 1479-1485. PMID 23026567 DOI: 10.1016/J.Jtcvs.2012.08.064  0.52
2012 Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, et al. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circulation Research. 110: 739-48. PMID 22282194 DOI: 10.1161/Circresaha.111.258426  0.52
2011 Horita HN, Simpson PA, Ostriker A, Furgeson S, Van Putten V, Weiser-Evans MC, Nemenoff RA. Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 2909-19. PMID 21940949 DOI: 10.1161/Atvbaha.111.233585  0.52
2011 Andrés-Hernando A, Altmann C, Ahuja N, Lanaspa MA, Nemenoff R, He Z, Ishimoto T, Simpson PA, Weiser-Evans MC, Bacalja J, Faubel S. Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice. American Journal of Physiology. Renal Physiology. 301: F907-16. PMID 21677145 DOI: 10.1152/Ajprenal.00107.2011  0.52
2011 Nemenoff RA, Horita H, Ostriker AC, Furgeson SB, Simpson PA, VanPutten V, Crossno J, Offermanns S, Weiser-Evans MC. SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1300-8. PMID 21415388 DOI: 10.1161/Atvbaha.111.223701  0.52
2010 Tennis MA, Van Scoyk MM, Freeman SV, Vandervest KM, Nemenoff RA, Winn RA. Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer. Molecular Cancer Research : McR. 8: 833-43. PMID 20501643 DOI: 10.1158/1541-7786.Mcr-09-0400  0.52
2010 Tennis MA, Van Scoyk M, Heasley LE, Vandervest K, Weiser-Evans M, Freeman S, Keith RL, Simpson P, Nemenoff RA, Winn RA. Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1. Neoplasia (New York, N.Y.). 12: 244-53. PMID 20234818 DOI: 10.1593/Neo.91690  0.52
2010 Choudhary R, Li H, Winn RA, Sorenson AL, Weiser-Evans MCM, Nemenoff RA. Peroxisome proliferator-activated receptor-γ inhibits transformed growth of non-small cell lung cancer cells through selective suppression of snail Neoplasia. 12: 224-234. PMID 20234816 DOI: 10.1593/Neo.91638  0.52
2010 Meng L, Van Putten V, Qu L, Nemenoff RA, Shang MY, Cai SQ, Li X. Altered expression of genes profiles modulated by a combination of Astragali Radix and Angelicae Sinensis Radix in obstructed rat kidney. Planta Medica. 76: 1431-8. PMID 20195958 DOI: 10.1055/S-0029-1240943  0.56
2010 Furgeson SB, Simpson PA, Park I, Vanputten V, Horita H, Kontos CD, Nemenoff RA, Weiser-Evans MC. Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation. Cardiovascular Research. 86: 274-82. PMID 20051384 DOI: 10.1093/Cvr/Cvp425  0.52
2010 Coldren CD, Sugita M, Gao D, Miller YE, Merrick DT, Franklin WA, Keith RL, Hirsch FR, Geraci MW, Nemenoff RA. Assessing lung cancer risk in bronchial dysplasia by identification of prognostic gene expression profiles Clinical Cancer Research. 16. DOI: 10.1158/Diag-10-B15  0.4
2010 Li HY, Sorenson A, Amin J, Middleton D, Weiser-Evans M, Nemenoff RA. Abstract 2266: Pioglitazone increases tumor progression and metastasis in an orthotopic mouse model of non-small cell lung cancer Cancer Research. 70: 2266-2266. DOI: 10.1158/1538-7445.Am10-2266  0.32
2009 Weiser-Evans MCM, Wang XQ, Amin J, Van Putten V, Choudhary R, Winn RA, Scheinman R, Simpson P, Geraci MW, Nemenoff RA. Depletion of cytosolic phospholipase A 2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis Cancer Research. 69: 1733-1738. PMID 19208832 DOI: 10.1158/0008-5472.Can-08-3766  0.52
2009 Wang XQ, Li H, Van Putten V, Winn RA, Heasley LE, Nemenoff RA. Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9. Molecular Biology of the Cell. 20: 791-800. PMID 19037103 DOI: 10.1091/Mbc.E08-07-0732  0.52
2009 Marek L, Ware KE, Fritzsche A, Hercule P, Helton WR, Smith JE, McDermott LA, Coldren CD, Nemenoff RA, Merrick DT, Helfrich BA, Bunn PA, Heasley LE. Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells. Molecular Pharmacology. 75: 196-207. PMID 18849352 DOI: 10.1124/Mol.108.049544  0.52
2008 Nemenoff R, Meyer AM, Hudish TM, Mozer AB, Snee A, Narumiya S, Stearman RS, Winn RA, Weiser-Evans M, Geraci MW, Keith RL. Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator--activated receptor gamma. Cancer Prevention Research (Philadelphia, Pa.). 1: 349-56. PMID 19138979 DOI: 10.1158/1940-6207.Capr-08-0145  0.52
2008 Nemenoff RA, Weiser-Evans M, Winn RA. Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-gamma Ligands in Lung Cancer. Ppar Research. 2008: 156875. PMID 18509496 DOI: 10.1155/2008/156875  0.32
2008 Nemenoff RA, Simpson PA, Furgeson SB, Kaplan-Albuquerque N, Crossno J, Garl PJ, Cooper J, Weiser-Evans MC. Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha. Circulation Research. 102: 1036-45. PMID 18340011 DOI: 10.1161/Circresaha.107.169896  0.32
2008 Bren-Mattison Y, Meyer AM, Van Putten V, Li H, Kuhn K, Stearman R, Weiser-Evans M, Winn RA, Heasley LE, Nemenoff RA. Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB. Molecular Pharmacology. 73: 709-17. PMID 18055759 DOI: 10.1124/Mol.107.042002  0.52
2008 Nemenoff RA, Weiser-Evans M, Winn RA. Activation and molecular targets of peroxisome proliferator-activated receptor-γ ligands in lung cancer Ppar Research. DOI: 10.1155/2008/156875  0.52
2006 Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT, Heasley LE, Nemenoff RA. Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma. The Journal of Biological Chemistry. 281: 26943-50. PMID 16835228 DOI: 10.1074/Jbc.M604145200  0.52
2006 Meyer AM, Dwyer-Nield LD, Hurteau G, Keith RL, Ouyang Y, Freed BM, Kisley LR, Geraci MW, Bonventre JV, Nemenoff RA, Malkinson AM. Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L1260-6. PMID 16443645 DOI: 10.1152/Ajplung.00182.2005  0.52
2005 Nana-Sinkam P, Oyer RJ, Stearman RS, Sotto-Santiago S, Moore MD, Bull TM, Grady MC, Choudhery Q, Nemenoff RA, Lane K, Loyd JE, Geraci MW. Prostacyclin synthase promoter regulation and familial pulmonary arterial hypertension. Chest. 128: 612S. PMID 16373865 DOI: 10.1378/Chest.128.6_Suppl.612S  0.32
2005 Ihida-Stansbury K, McKean DM, Gebb SA, Martin JF, Stevens T, Nemenoff R, Vaughn J, Lane K, Loyd J, Wheeler L, Morrell NW, Ivy D, Jones PL. Regulation and functions of the paired-related homeobox gene PRX1 in pulmonary vascular development and disease. Chest. 128: 591S. PMID 16373852 DOI: 10.1378/Chest.128.6_Suppl.591S  0.52
2005 Stearman RS, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn PA, Johnson GL, Hirsch FR, Merrick DT, Franklin WA, Baron AE, Keith RL, Nemenoff RA, Malkinson AM, Geraci MW. Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. The American Journal of Pathology. 167: 1763-75. PMID 16314486 DOI: 10.1016/S0002-9440(10)61257-6  0.52
2005 Nemenoff RA, Winn RA. Role of nuclear receptors in lung tumourigenesis European Journal of Cancer. 41: 2561-2568. PMID 16199155 DOI: 10.1016/J.Ejca.2005.08.015  0.52
2005 Kaplan-Albuquerque N, Van Putten V, Weiser-Evans MC, Nemenoff RA. Depletion of serum response factor by RNA interference mimics the mitogenic effects of platelet derived growth factor-BB in vascular smooth muscle cells. Circulation Research. 97: 427-33. PMID 16081871 DOI: 10.1161/01.Res.0000179776.40216.A9  0.56
2005 Kaplan-Albuquerque N, Bogaert YE, Van Putten V, Weiser-Evans MC, Nemenoff RA. Patterns of gene expression differentially regulated by platelet-derived growth factor and hypertrophic stimuli in vascular smooth muscle cells: markers for phenotypic modulation and response to injury. The Journal of Biological Chemistry. 280: 19966-76. PMID 15774477 DOI: 10.1074/Jbc.M500917200  0.56
2005 Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N, Bren-Mattison Y, Van Raay TJ, Nemenoff RA, Heasley LE. Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. The Journal of Biological Chemistry. 280: 19625-34. PMID 15705594 DOI: 10.1074/Jbc.M409392200  0.52
2005 Bren-Mattison Y, Van Putten V, Chan D, Winn R, Geraci MW, Nemenoff RA. Peroxisome proliferator-activated receptor-gamma (PPAR(gamma)) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC). Oncogene. 24: 1412-22. PMID 15608671 DOI: 10.1038/Sj.Onc.1208333  0.52
2005 Wick MJ, Blaine S, Van Putten V, Saavedra M, Nemenoff RA. Lung Krüppel-like factor (LKLF) is a transcriptional activator of the cytosolic phospholipase A2 alpha promoter. The Biochemical Journal. 387: 239-46. PMID 15540987 DOI: 10.1042/Bj20041458  0.56
2005 Blaine SA, Meyer AM, Hurteau G, Wick M, Hankin JA, Murphy RC, Dannenberg AJ, Geraci MW, Subbaramaiah K, Nemenoff RA. Targeted over-expression of mPGES-1 and elevated PGE2 production is not sufficient for lung tumorigenesis in mice. Carcinogenesis. 26: 209-17. PMID 15471895 DOI: 10.1093/Carcin/Bgh302  0.52
2004 Marek L, Levresse V, Amura C, Zentrich E, Van Putten V, Nemenoff RA, Heasley LE. Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells. Journal of Cellular Physiology. 201: 459-69. PMID 15389548 DOI: 10.1002/Jcp.20087  0.52
2004 Keith RL, Miller YE, Hudish TM, Girod CE, Sotto-Santiago S, Franklin WA, Nemenoff RA, March TH, Nana-Sinkam SP, Geraci MW. Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice. Cancer Research. 64: 5897-904. PMID 15313935 DOI: 10.1158/0008-5472.Can-04-1070  0.52
2004 Nana-Sinkam P, Golpon H, Keith RL, Oyer RJ, Sotto-Santiago S, Moore MD, Franklin W, Nemenoff RA, Geraci MW. Prostacyclin in human non-small cell lung cancers. Chest. 125: 141S. PMID 15136467 DOI: 10.1378/Chest.125.5_Suppl.141S  0.52
2004 Ihida-Stansbury K, McKean DM, Gebb SA, Martin JF, Stevens T, Nemenoff R, Akeson A, Vaughn J, Jones PL. Paired-related homeobox gene Prx1 is required for pulmonary vascular development. Circulation Research. 94: 1507-14. PMID 15117820 DOI: 10.1161/01.Res.0000130656.72424.20  0.52
2004 Meyer AM, Dwyer-Nield LD, Hurteau GJ, Keith RL, O'Leary E, You M, Bonventre JV, Nemenoff RA, Malkinson AM. Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2. Carcinogenesis. 25: 1517-24. PMID 15033900 DOI: 10.1093/Carcin/Bgh150  0.52
2003 Kaplan-Albuquerque N, Garat C, Desseva C, Jones PL, Nemenoff RA. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. The Journal of Biological Chemistry. 278: 39830-8. PMID 12882977 DOI: 10.1074/Jbc.M305991200  0.56
2003 Kaplan-Albuquerque N, Garat C, Van Putten V, Nemenoff RA. Regulation of SM22 alpha expression by arginine vasopressin and PDGF-BB in vascular smooth muscle cells. American Journal of Physiology. Heart and Circulatory Physiology. 285: H1444-52. PMID 12829429 DOI: 10.1152/Ajpheart.00306.2003  0.56
2003 Walker HA, Whitelock JM, Garl PJ, Nemenoff RA, Stenmark KR, Weiser-Evans MC. Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling. Molecular Biology of the Cell. 14: 1941-52. PMID 12802066 DOI: 10.1091/Mbc.E02-08-0508  0.52
2003 McKean DM, Sisbarro L, Ilic D, Kaplan-Alburquerque N, Nemenoff R, Weiser-Evans M, Kern MJ, Jones PL. FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration. The Journal of Cell Biology. 161: 393-402. PMID 12741393 DOI: 10.1083/Jcb.Jcb.200302126  0.52
2003 Ameshima S, Golpon H, Cool CD, Chan D, Vandivier RW, Gardai SJ, Wick M, Nemenoff RA, Geraci MW, Voelkel NF. Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. Circulation Research. 92: 1162-9. PMID 12714563 DOI: 10.1161/01.Res.0000073585.50092.14  0.64
2003 Tock J, Van Putten V, Stenmark KR, Nemenoff RA. Induction of SM-alpha-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase. Biochemical and Biophysical Research Communications. 301: 1116-21. PMID 12589828 DOI: 10.1016/S0006-291X(03)00087-1  0.56
2002 Gurevich AK, Falk SA, Nemenoff RA, Weinberger HD, Summer SN, Rizeq M, Gengaro PE, Bedigian MP, Schrier RW. Effects of angiotensin receptor blockade on haemodynamics and gene expression after myocardial infarction Drugs in R and D. 3: 239-249. PMID 12455200 DOI: 10.2165/00126839-200203040-00004  0.52
2002 Wick M, Hurteau G, Dessev C, Chan D, Geraci MW, Winn RA, Heasley LE, Nemenoff RA. Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth. Molecular Pharmacology. 62: 1207-14. PMID 12391285 DOI: 10.1124/Mol.62.5.1207  0.52
2002 Keith RL, Miller YE, Hoshikawa Y, Moore MD, Gesell TL, Gao B, Malkinson AM, Golpon HA, Nemenoff RA, Geraci MW. Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer. Cancer Research. 62: 734-40. PMID 11830527  0.52
2001 Blaine SA, Wick M, Dessev C, Nemenoff RA. Induction of cPLA2 in lung epithelial cells and non-small cell lung cancer is mediated by Sp1 and c-Jun. The Journal of Biological Chemistry. 276: 42737-43. PMID 11559711 DOI: 10.1074/Jbc.M107773200  0.64
2001 Van Putten V, Refaat Z, Dessev C, Blaine S, Wick M, Butterfield L, Han SY, Heasley LE, Nemenoff RA. Induction of cytosolic phospholipase A2 by oncogenic Ras is mediated through the JNK and ERK pathways in rat epithelial cells. The Journal of Biological Chemistry. 276: 1226-32. PMID 11042196 DOI: 10.1074/Jbc.M003581200  0.52
2000 Garat C, Van Putten V, Refaat ZA, Dessev C, Han SY, Nemenoff RA. Induction of smooth muscle alpha-actin in vascular smooth muscle cells by arginine vasopressin is mediated by c-Jun amino-terminal kinases and p38 mitogen-activated protein kinase. The Journal of Biological Chemistry. 275: 22537-43. PMID 10807920 DOI: 10.1074/Jbc.M003000200  0.64
1999 Stenmark KR, Frid M, Nemenoff R, Dempsey EC, Das M. Hypoxia induces cell-specific changes in gene expression in vascular wall cells: implications for pulmonary hypertension. Advances in Experimental Medicine and Biology. 474: 231-58. PMID 10635005 DOI: 10.1007/978-1-4615-4711-2_19  0.52
1999 Frid MG, Aldashev AA, Nemenoff RA, Higashito R, Westcott JY, Stenmark KR. Subendothelial cells from normal bovine arteries exhibit autonomous growth and constitutively activated intracellular signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 2884-93. PMID 10591665 DOI: 10.1161/01.Atv.19.12.2884  0.52
1997 Li X, Van Putten V, Zarinetchi F, Nicks ME, Thaler S, Heasley LE, Nemenoff RA. Suppression of smooth-muscle alpha-actin expression by platelet-derived growth factor in vascular smooth-muscle cells involves Ras and cytosolic phospholipase A2. The Biochemical Journal. 327: 709-16. PMID 9581546 DOI: 10.1042/bj3270709  0.52
1997 Edelstein CL, Ling H, Gengaro PE, Nemenoff RA, Bahr BA, Schrier RW. Effect of glycine on prelethal and postlethal increases in calpain activity in rat renal proximal tubules. Kidney International. 52: 1271-8. PMID 9350650 DOI: 10.1038/Ki.1997.452  0.52
1997 Higashita R, Li L, Van Putten V, Yamamura Y, Zarinetchi F, Heasley L, Nemenoff RA. Galpha16 mimics vasoconstrictor action to induce smooth muscle alpha-actin in vascular smooth muscle cells through a Jun-NH2-terminal kinase-dependent pathway. The Journal of Biological Chemistry. 272: 25845-50. PMID 9325315 DOI: 10.1074/Jbc.272.41.25845  0.52
1997 Heasley LE, Thaler S, Nicks M, Price B, Skorecki K, Nemenoff RA. Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer. The Journal of Biological Chemistry. 272: 14501-4. PMID 9169405 DOI: 10.1074/Jbc.272.23.14501  0.52
1996 Nègre-Aminou P, Nemenoff RA, Wood MR, De La Houssaye BA, Pfenninger KH. Characterization of phospholipase A2 activity enriched in the nerve growth cone Journal of Neurochemistry. 67: 2599-2608. PMID 8931495 DOI: 10.1046/J.1471-4159.1996.67062599.X  0.52
1996 Alkhunaizi AM, Yaqoob MM, Edelstein CL, Gengaro PE, Burke TJ, Nemenoff RA, Schrier RW. Arachidonic acid protects against hypoxic injury in rat proximal tubules Kidney International. 49: 620-625. PMID 8648901 DOI: 10.1038/Ki.1996.89  0.52
1996 Ginès P, Li X, Brown SE, Nakamura T, Guzelian PS, Heasley LE, Schrier RW, Nemenoff RA. Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes. Hepatology (Baltimore, Md.). 23: 1167-73. PMID 8621150 DOI: 10.1002/Hep.510230535  0.52
1995 Kim DK, Rordorf G, Nemenoff RA, Koroshetz WJ, Bonventre JV. Glutamate stably enhances the activity of two cytosolic forms of phospholipase A2 in brain cortical cultures. The Biochemical Journal. 310: 83-90. PMID 7646475 DOI: 10.1042/Bj3100083  0.52
1995 Edelstein CL, Wieder ED, Yaqoob MM, Gengaro PE, Burke TJ, Nemenoff RA, Schrier RW. The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury Proceedings of the National Academy of Sciences of the United States of America. 92: 7662-7666. PMID 7644473 DOI: 10.1073/Pnas.92.17.7662  0.52
1995 Ginès P, Li X, Zamarripa JL, Brown SE, Wieder ED, Nakamura T, Guzelian PS, Schrier RW, Heasley LE, Nemenoff RA. Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes. Hepatology (Baltimore, Md.). 22: 1296-303. PMID 7557884 DOI: 10.1016/0270-9139(95)90642-8  0.52
1994 Bunnachak D, Almeida ARP, Wetzels JFM, Gengaro P, Nemenoff RA, Burke TJ, Schrier RW. Ca2+ uptake, fatty acid, and LDH release during proximal tubule hypoxia: Effects of mepacrine and dibucaine American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 266. PMID 8141320 DOI: 10.1152/Ajprenal.1994.266.2.F196  0.52
1994 Gronich J, Konieczkowski M, Gelb MH, Nemenoff RA, Sedor JR. Interleukin 1α causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells Journal of Clinical Investigation. 93: 1224-1233. PMID 8132762 DOI: 10.1172/Jci117076  0.52
1993 Wetzels JFM, Wang X, Gengaro PE, Nemenoff RA, Burke TJ, Schrier RW. Glycine protection against hypoxic but not phospholipase A2-induced injury in rat proximal tubules American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 264. PMID 8430835 DOI: 10.1152/Ajprenal.1993.264.1.F94  0.52
1987 Blackshear PJ, Nemenoff RA, Hovis JG, Halsey DL, Stumpo DJ, Huang JK. Insulin action in normal and protein kinase C-deficient rat hepatoma cells. Effects on protein phosphorylation, protein kinase activities, and ornithine decarboxylase activities and messenger ribonucleic acid levels. Molecular Endocrinology (Baltimore, Md.). 1: 44-52. PMID 3331710 DOI: 10.1210/Mend-1-1-44  0.52
1986 Blackshear PJ, Wen L, Nemenoff RA, Gunsalus JR, Witters LA. Chapter 16 Growth factor activation of protein kinase C-dependent and -independent pathways of protein phosphorylation in fibroblasts: relevance to activation of protein kinase C in neuronal tissues Progress in Brain Research. 69: 183-195. PMID 3447230 DOI: 10.1016/S0079-6123(08)61059-6  0.52
1984 Blackshear PJ, Nemenoff RA, Avruch J. Characteristics of insulin and epidermal growth factor stimulation of receptor autophosphorylation in detergent extracts of rat liver and transplantable rat hepatomas Endocrinology. 114: 141-152. PMID 6317340 DOI: 10.1210/Endo-114-1-141  0.52
1983 Blackshear PJ, Nemenoff RA, Avruch J. Insulin binds to and promotes the phosphorylation of a Mr 210 000 component of its receptor in detergent extracts of rat liver microsomes Febs Letters. 158: 243-246. PMID 6347713 DOI: 10.1016/0014-5793(83)80587-0  0.52
1982 Blackshear PJ, Nemenoff RA, Avruch J. Preliminary characterization of a heat-stable protein from rat adipose tissue whose phosphorylation is stimulated by insulin Biochemical Journal. 204: 817-824. PMID 6751318 DOI: 10.1042/Bj2040817  0.52
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