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David L. Spector - Publications

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
Nuclear Domains

169 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Sun L, Kees T, Almeida AS, Liu B, He XY, Ng D, Han X, Spector DL, McNeish IA, Gimotty P, Adams S, Egeblad M. Activating a collaborative innate-adaptive immune response to control metastasis. Cancer Cell. PMID 34478639 DOI: 10.1016/j.ccell.2021.08.005  1
2021 Yu AT, Berasain C, Bhatia S, Rivera K, Liu B, Rigo F, Pappin DJ, Spector DL. lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR. Elife. 10. PMID 34002693 DOI: 10.7554/eLife.68263  1
2021 Chang KC, Spector DL. : a long non-coding RNA involved in breast cancer progression. Molecular & Cellular Oncology. 8: 1882286. PMID 33860086 DOI: 10.1080/23723556.2021.1882286  1
2020 Chang KC, Diermeier SD, Yu AT, Brine LD, Russo S, Bhatia S, Alsudani H, Kostroff K, Bhuiya T, Brogi E, Pappin DJ, Bennett CF, Rigo F, Spector DL. MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression. Nature Communications. 11: 6438. PMID 33353933 DOI: 10.1038/s41467-020-20207-y  1
2020 Aganezov S, Goodwin S, Sherman RM, Sedlazeck FJ, Arun G, Bhatia S, Lee I, Kirsche M, Wappel R, Kramer M, Kostroff K, Spector DL, Timp W, McCombie WR, Schatz MC. Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing. Genome Research. PMID 32887686 DOI: 10.1101/Gr.260497.119  1
2020 Arun G, Aggarwal D, Spector DL. Long Non-Coding RNA: Functional Implications. Non-Coding Rna. 6. PMID 32503170 DOI: 10.3390/Ncrna6020022  1
2019 Arun G, Spector DL. MALAT1 long non-coding RNA and breast cancer. Rna Biology. 1-4. PMID 30874469 DOI: 10.1080/15476286.2019.1592072  1
2019 Abulwerdi FA, Xu W, Ageeli AA, Yonkunas MJ, Arun G, Nam H, Schneekloth JS, Dayie TK, Spector D, Baird N, Le Grice SFJ. Selective small molecule targeting of a triple helix encoded by the long non-coding RNA, MALAT1. Acs Chemical Biology. PMID 30620551 DOI: 10.1021/Acschembio.8B00807  1
2018 Huang YH, Klingbeil O, He XY, Wu XS, Arun G, Lu B, Somerville TDD, Milazzo JP, Wilkinson JE, Demerdash OE, Spector DL, Egeblad M, Shi J, Vakoc CR. POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes & Development. PMID 29945888 DOI: 10.1101/Gad.314815.118  1
2018 Arun G, Diermeier SD, Spector DL. Therapeutic Targeting of Long Non-Coding RNAs in Cancer. Trends in Molecular Medicine. PMID 29449148 DOI: 10.1016/J.Molmed.2018.01.001  1
2017 Diermeier SD, Spector DL. Antisense Oligonucleotide-mediated Knockdown in Mammary Tumor Organoids. Bio-Protocol. 7. PMID 28932764 DOI: 10.21769/BioProtoc.2511  1
2017 Li MA, Amaral PP, Cheung P, Bergmann JH, Kinoshita M, Kalkan T, Ralser M, Robson S, Meyenn FV, Paramor M, Yang F, Chen C, Nichols J, Spector DL, Kouzarides T, et al. A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation. Elife. 6. PMID 28820723 DOI: 10.7554/Elife.23468  1
2017 Zhang B, Mao YS, Diermeier SD, Novikova IV, Nawrocki EP, Jones TA, Lazar Z, Tung CS, Luo W, Eddy SR, Sanbonmatsu KY, Spector DL. Identification and Characterization of a Class of MALAT1-like Genomic Loci. Cell Reports. 19: 1723-1738. PMID 28538188 DOI: 10.1016/J.Celrep.2017.05.006  1
2017 Li MA, Amaral PP, Cheung P, Bergmann JH, Kinoshita M, Kalkan T, Ralser M, Robson S, Meyenn Fv, Paramor M, Yang F, Chen C, Nichols J, Spector DL, Kouzarides T, et al. Author response: A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation Elife. DOI: 10.7554/Elife.23468.032  1
2016 Diermeier SD, Chang KC, Freier SM, Song J, El Demerdash O, Krasnitz A, Rigo F, Bennett CF, Spector DL. Mammary Tumor-Associated RNAs Impact Tumor Cell Proliferation, Invasion, and Migration. Cell Reports. 17: 261-74. PMID 27681436 DOI: 10.1016/J.Celrep.2016.08.081  1
2016 Pernar LI, Lockridge R, McCormack C, Chen J, Shikora SA, Spector D, Tavakkoli A, Vernon AH, Robinson MK. An Effort to Develop an Algorithm to Target Abdominal CT Scans for Patients After Gastric Bypass. Obesity Surgery. PMID 27523471 DOI: 10.1007/S11695-016-2324-8  1
2016 Arun G, Diermeier S, Akerman M, Chang K, Wilkinson JE, Hearn S, Kim Y, MacLeod AR, Krainer AR, Norton L, Brogi E, Egeblad M, Spector DL. Abstract PR11: Differentiation of mammary tumors and reduction in metastasis upon Malat1 LncRNA loss Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-Pr11  1
2016 Diermeier SD, Chang K, Freier SM, Rigo F, Bennett CF, Spector DL. Abstract A43: Long noncoding RNAs as targets of mammary tumor cell proliferation and migration Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-A43  1
2015 Arun G, Diermeier S, Akerman M, Chang KC, Wilkinson JE, Hearn S, Kim Y, MacLeod AR, Krainer AR, Norton L, Brogi E, Egeblad M, Spector DL. Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes & Development. PMID 26701265 DOI: 10.1101/Gad.270959.115  1
2015 Zepeda-Mendoza CJ, Mukhopadhyay S, Wong ES, Harder N, Splinter E, de Wit E, Eckersley-Maslin MA, Ried T, Eils R, Rohr K, Mills A, de Laat W, Flicek P, Sengupta AM, Spector DL. Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2. Bmc Genomics. 16: 982. PMID 26589460 DOI: 10.1186/S12864-015-2137-5  1
2015 Bergmann JH, Li J, Eckersley-Maslin MA, Rigo F, Freier SM, Spector DL. Regulation of the ESC transcriptome by nuclear long noncoding RNAs. Genome Research. PMID 26048247 DOI: 10.1101/Gr.189027.114  1
2015 Hogan MS, Parfitt DE, Zepeda-Mendoza CJ, Shen MM, Spector DL. Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation. Cell Stem Cell. 16: 275-88. PMID 25748933 DOI: 10.1016/J.Stem.2015.02.001  1
2015 Spector D, Perry Z, Shah S, Kim JJ, Tarnoff ME, Shikora SA. Roux-en-Y gastric bypass: hyperamylasemia is associated with small bowel obstruction. Surgery For Obesity and Related Diseases : Official Journal of the American Society For Bariatric Surgery. 11: 38-43. PMID 25264325 DOI: 10.1016/J.Soard.2014.04.030  0.01
2015 Tektonidis M, Kim IH, Chen YC, Eils R, Spector DL, Rohr K. Non-rigid multi-frame registration of cell nuclei in live cell fluorescence microscopy image data. Medical Image Analysis. 19: 1-14. PMID 25181702 DOI: 10.1016/J.Media.2014.07.006  1
2014 Eckersley-Maslin MA, Spector DL. Random monoallelic expression: regulating gene expression one allele at a time. Trends in Genetics : Tig. 30: 237-44. PMID 24780084 DOI: 10.1016/J.Tig.2014.03.003  1
2014 Bell RD, Long X, Lin M, Bergmann JH, Nanda V, Cowan SL, Zhou Q, Han Y, Spector DL, Zheng D, Miano JM. Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1249-59. PMID 24578380 DOI: 10.1161/Atvbaha.114.303240  1
2014 Eckersley-Maslin MA, Thybert D, Bergmann JH, Marioni JC, Flicek P, Spector DL. Random monoallelic gene expression increases upon embryonic stem cell differentiation. Developmental Cell. 28: 351-65. PMID 24576421 DOI: 10.1016/J.Devcel.2014.01.017  1
2014 Bergmann JH, Spector DL. Long non-coding RNAs: modulators of nuclear structure and function. Current Opinion in Cell Biology. 26: 10-8. PMID 24529241 DOI: 10.1016/J.Ceb.2013.08.005  1
2013 Dowen JM, Bilodeau S, Orlando DA, Hübner MR, Abraham BJ, Spector DL, Young RA. Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements. Stem Cell Reports. 1: 371-8. PMID 24286025 DOI: 10.1016/J.Stemcr.2013.09.002  1
2013 Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, ... ... Spector DL, et al. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes & Development. 27: 2648-62. PMID 24285714 DOI: 10.1101/Gad.232710.113  1
2013 Chen Z, Jaafar L, Agyekum DG, Xiao H, Wade MF, Kumaran RI, Spector DL, Bao G, Porteus MH, Dynan WS, Meiler SE. Receptor-mediated delivery of engineered nucleases for genome modification. Nucleic Acids Research. 41: e182. PMID 23956220 DOI: 10.1093/Nar/Gkt710  1
2013 Bodnar MS, Spector DL. Chromatin meets its organizers. Cell. 153: 1187-9. PMID 23746835 DOI: 10.1016/J.Cell.2013.05.030  1
2013 Eckersley-Maslin MA, Bergmann JH, Lazar Z, Spector DL. Lamin A/C is expressed in pluripotent mouse embryonic stem cells. Nucleus (Austin, Tex.). 4: 53-60. PMID 23324457 DOI: 10.4161/Nucl.23384  1
2013 Hübner MR, Eckersley-Maslin MA, Spector DL. Chromatin organization and transcriptional regulation. Current Opinion in Genetics & Development. 23: 89-95. PMID 23270812 DOI: 10.1016/J.Gde.2012.11.006  1
2013 Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zörnig M, MacLeod AR, Spector DL, Diederichs S. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Research. 73: 1180-9. PMID 23243023 DOI: 10.1158/0008-5472.Can-12-2850  1
2013 Gutschner T, Hämmerle M, Eißmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Groß M, Zörnig M, MacLeod AR, Spector DL, Diederichs S. Abstract 1121: The long non-coding RNA MALAT1 is an essential gene regulator for lung cancer metastasis in a novel human knockout model . Cancer Research. 73: 1121-1121. DOI: 10.1158/1538-7445.Am2013-1121  1
2012 Zhang B, Arun G, Mao YS, Lazar Z, Hung G, Bhattacharjee G, Xiao X, Booth CJ, Wu J, Zhang C, Spector DL. The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. Cell Reports. 2: 111-23. PMID 22840402 DOI: 10.1016/J.Celrep.2012.06.003  1
2011 Zhao R, Nakamura T, Fu Y, Lazar Z, Spector DL. Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation. Nature Cell Biology. 13: 1295-304. PMID 21983563 DOI: 10.1038/Ncb2341  1
2011 Spector DL. Immunofluorescence localization of nuclear proteins. Cold Spring Harbor Protocols. 2011: 1276-80. PMID 21969615 DOI: 10.1101/Pdb.Prot065755  1
2011 Mao YS, Zhang B, Spector DL. Biogenesis and function of nuclear bodies. Trends in Genetics : Tig. 27: 295-306. PMID 21680045 DOI: 10.1016/J.Tig.2011.05.006  1
2011 Shi L, Wang J, Hong F, Spector DL, Fang Y. Four amino acids guide the assembly or disassembly of Arabidopsis histone H3.3-containing nucleosomes. Proceedings of the National Academy of Sciences of the United States of America. 108: 10574-8. PMID 21670303 DOI: 10.1073/Pnas.1017882108  1
2011 Mao YS, Sunwoo H, Zhang B, Spector DL. Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs. Nature Cell Biology. 13: 95-101. PMID 21170033 DOI: 10.1038/Ncb2140  1
2011 Spector DL, Lamond AI. Nuclear speckles. Cold Spring Harbor Perspectives in Biology. 3. PMID 20926517 DOI: 10.1101/cshperspect.a000646  1
2011 Kim IH, Chen YC, Spector DL, Eils R, Rohr K. Nonrigid registration of 2-D and 3-D dynamic cell nuclei images for improved classification of subcellular particle motion. Ieee Transactions On Image Processing : a Publication of the Ieee Signal Processing Society. 20: 1011-22. PMID 20840894 DOI: 10.1109/Tip.2010.2076377  1
2011 Harder N, Bodnar M, Eils R, Spector DL, Rohr K. 3D segmentation and quantification of mouse embryonic stem cells in fluorescence microscopy images Informatik Aktuell. 34-38. DOI: 10.1007/978-3-642-19335-4_9  1
2010 Hübner MR, Spector DL. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harbor Symposia On Quantitative Biology. 75: 43-9. PMID 21209387 DOI: 10.1101/Sqb.2010.75.020  1
2010 Spector DL, Goldman RD. Constructing and expressing fluorescent protein fusions. Cold Spring Harbor Protocols. 2010: pdb.top87. PMID 21041402 DOI: 10.1101/Pdb.Top87  1
2010 Spector DL, Goldman RD. Transfection of mammalian cells with fluorescent protein fusions. Cold Spring Harbor Protocols. 2010: pdb.prot5517. PMID 21041390 DOI: 10.1101/Pdb.Prot5517  1
2010 Oda H, Hübner MR, Beck DB, Vermeulen M, Hurwitz J, Spector DL, Reinberg D. Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Molecular Cell. 40: 364-76. PMID 21035370 DOI: 10.1016/J.Molcel.2010.10.011  1
2010 Prasanth KV, Camiolo M, Chan G, Tripathi V, Denis L, Nakamura T, Hübner MR, Spector DL. Nuclear organization and dynamics of 7SK RNA in regulating gene expression. Molecular Biology of the Cell. 21: 4184-96. PMID 20881057 DOI: 10.1091/Mbc.E10-02-0105  1
2010 Bernard D, Prasanth KV, Tripathi V, Colasse S, Nakamura T, Xuan Z, Zhang MQ, Sedel F, Jourdren L, Coulpier F, Triller A, Spector DL, Bessis A. A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. The Embo Journal. 29: 3082-93. PMID 20729808 DOI: 10.1038/Emboj.2010.199  1
2010 Hübner MR, Spector DL. Chromatin dynamics. Annual Review of Biophysics. 39: 471-89. PMID 20462379 DOI: 10.1146/annurev.biophys.093008.131348  1
2010 Ben-Ari Y, Brody Y, Kinor N, Mor A, Tsukamoto T, Spector DL, Singer RH, Shav-Tal Y. The life of an mRNA in space and time. Journal of Cell Science. 123: 1761-74. PMID 20427315 DOI: 10.1242/Jcs.062638  1
2010 Spector D, Shikora S. Neuro-modulation and bariatric surgery for type 2 diabetes mellitus International Journal of Clinical Practice. Supplement. 53-58. PMID 20377665 DOI: 10.1111/J.1742-1241.2009.02279.X  1
2010 Fang Y, Spector DL. Live cell imaging of plants. Cold Spring Harbor Protocols. 2010: pdb.top68. PMID 20150164 DOI: 10.1101/Pdb.Top68  1
2010 Fang Y, Spector DL. Four-dimensional imaging of plant cells during the cell cycle. Cold Spring Harbor Protocols. 2010: pdb.prot5381. PMID 20150144 DOI: 10.1101/Pdb.Prot5381  1
2010 Fang Y, Spector DL. BiFC imaging assay for plant protein-protein interactions. Cold Spring Harbor Protocols. 2010: pdb.prot5380. PMID 20150143 DOI: 10.1101/Pdb.Prot5380  1
2010 Wilusz JE, Spector DL. An unexpected ending: noncanonical 3' end processing mechanisms. Rna (New York, N.Y.). 16: 259-66. PMID 20007330 DOI: 10.1261/Rna.1907510  1
2009 Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional surprises from the RNA world. Genes & Development. 23: 1494-504. PMID 19571179 DOI: 10.1101/Gad.1800909  1
2009 Zhao R, Bodnar MS, Spector DL. Nuclear neighborhoods and gene expression. Current Opinion in Genetics & Development. 19: 172-9. PMID 19339170 DOI: 10.1016/J.Gde.2009.02.007  1
2009 Sunwoo H, Dinger ME, Wilusz JE, Amaral PP, Mattick JS, Spector DL. MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Research. 19: 347-59. PMID 19106332 DOI: 10.1101/Gr.087775.108  1
2008 Wilusz JE, Freier SM, Spector DL. 3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell. 135: 919-32. PMID 19041754 DOI: 10.1016/J.Cell.2008.10.012  1
2008 Dimitrova N, Chen YC, Spector DL, de Lange T. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature. 456: 524-8. PMID 18931659 DOI: 10.1038/Nature07433  1
2008 Chen YC, Kappel C, Beaudouin J, Eils R, Spector DL. Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis. Molecular Biology of the Cell. 19: 3147-62. PMID 18480407 DOI: 10.1091/Mbc.E08-01-0035  1
2008 Rosin FM, Watanabe N, Cacas JL, Kato N, Arroyo JM, Fang Y, May B, Vaughn M, Simorowski J, Ramu U, McCombie RW, Spector DL, Martienssen RA, Lam E. Genome-wide transposon tagging reveals location-dependent effects on transcription and chromatin organization in Arabidopsis. The Plant Journal : For Cell and Molecular Biology. 55: 514-25. PMID 18410481 DOI: 10.1111/J.1365-313X.2008.03517.X  1
2008 Kumaran RI, Thakar R, Spector DL. Chromatin dynamics and gene positioning. Cell. 132: 929-34. PMID 18358806 DOI: 10.1016/J.Cell.2008.03.004  1
2008 Kumaran RI, Spector DL. A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence. The Journal of Cell Biology. 180: 51-65. PMID 18195101 DOI: 10.1083/Jcb.200706060  1
2007 Fang Y, Spector DL. Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants. Current Biology : Cb. 17: 818-23. PMID 17442570 DOI: 10.1016/J.Cub.2007.04.005  1
2007 Prasanth KV, Spector DL. Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum. Genes & Development. 21: 11-42. PMID 17210785 DOI: 10.1101/Gad.1484207  1
2006 Spector DL, Goldman RD. Constructing and Expressing GFP Fusion Proteins. Csh Protocols. 2006. PMID 22484672 DOI: 10.1101/Pdb.Prot4649  1
2006 Spector DL. SnapShot: Cellular bodies. Cell. 127: 1071. PMID 17129789 DOI: 10.1016/J.Cell.2006.11.026  1
2006 Lee H, Quinn JC, Prasanth KV, Swiss VA, Economides KD, Camacho MM, Spector DL, Abate-Shen C. PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein. Genes & Development. 20: 784-94. PMID 16600910 DOI: 10.1101/Gad.1392006  1
2006 Politz JC, Tuft RA, Prasanth KV, Baudendistel N, Fogarty KE, Lifshitz LM, Langowski J, Spector DL, Pederson T. Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm. Molecular Biology of the Cell. 17: 1239-49. PMID 16371503 DOI: 10.1091/Mbc.E05-10-0952  1
2005 May BP, Lippman ZB, Fang Y, Spector DL, Martienssen RA. Differential regulation of strand-specific transcripts from Arabidopsis centromeric satellite repeats. Plos Genetics. 1: e79. PMID 16389298 DOI: 10.1371/Journal.Pgen.0010079  1
2005 Prasanth KV, Prasanth SG, Xuan Z, Hearn S, Freier SM, Bennett CF, Zhang MQ, Spector DL. Regulating gene expression through RNA nuclear retention. Cell. 123: 249-63. PMID 16239143 DOI: 10.1016/J.Cell.2005.08.033  1
2005 Fang Y, Spector DL. Centromere positioning and dynamics in living Arabidopsis plants. Molecular Biology of the Cell. 16: 5710-8. PMID 16195344 DOI: 10.1091/Mbc.E05-08-0706  1
2005 Spector DL, Goldman RD, Leinwand LA, Harlow E, Lane D. Immunoblot affinity purification Nature Methods. 2. DOI: 10.1038/Nmeth1005-797  1
2004 Bubulya PA, Prasanth KV, Deerinck TJ, Gerlich D, Beaudouin J, Ellisman MH, Ellenberg J, Spector DL. Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei. The Journal of Cell Biology. 167: 51-63. PMID 15479736 DOI: 10.1083/Jcb.200404120  1
2004 Spector DL. Stopping for FISH and chips along the chromatin fiber superhighway. Molecular Cell. 15: 844-6. PMID 15383273 DOI: 10.1016/J.Molcel.2004.09.013  1
2004 Prasanth SG, Prasanth KV, Siddiqui K, Spector DL, Stillman B. Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. The Embo Journal. 23: 2651-63. PMID 15215892 DOI: 10.1038/Sj.Emboj.7600624  1
2004 Shav-Tal Y, Darzacq X, Shenoy SM, Fusco D, Janicki SM, Spector DL, Singer RH. Dynamics of single mRNPs in nuclei of living cells. Science (New York, N.Y.). 304: 1797-800. PMID 15205532 DOI: 10.1126/Science.1099754  1
2004 Saitoh N, Spahr CS, Patterson SD, Bubulya P, Neuwald AF, Spector DL. Proteomic analysis of interchromatin granule clusters. Molecular Biology of the Cell. 15: 3876-90. PMID 15169873 DOI: 10.1091/Mbc.E04-03-0253  1
2004 Ono T, Fang Y, Spector DL, Hirano T. Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells. Molecular Biology of the Cell. 15: 3296-308. PMID 15146063 DOI: 10.1091/Mbc.E04-03-0242  1
2004 Bubulya PA, Spector DL. "On the move"ments of nuclear components in living cells. Experimental Cell Research. 296: 4-11. PMID 15120987 DOI: 10.1016/J.Yexcr.2004.03.018  1
2004 Fang Y, Hearn S, Spector DL. Tissue-specific expression and dynamic organization of SR splicing factors in Arabidopsis. Molecular Biology of the Cell. 15: 2664-73. PMID 15034145 DOI: 10.1091/Mbc.E04-02-0100  1
2004 Janicki SM, Tsukamoto T, Salghetti SE, Tansey WP, Sachidanandam R, Prasanth KV, Ried T, Shav-Tal Y, Bertrand E, Singer RH, Spector DL. From silencing to gene expression: real-time analysis in single cells. Cell. 116: 683-98. PMID 15006351 DOI: 10.1016/S0092-8674(04)00171-0  1
2004 Izaurralde E, Spector DL. Nucleus and gene expression: The interplay of transcriptional and post-transcriptional mechanisms that regulate gene expression Current Opinion in Cell Biology. 16: 219-222. DOI: 10.1016/J.Ceb.2004.04.005  1
2003 Spector DL. The dynamics of chromosome organization and gene regulation. Annual Review of Biochemistry. 72: 573-608. PMID 14527325 DOI: 10.1146/Annurev.Biochem.72.121801.161724  1
2003 Lamond AI, Spector DL. Nuclear speckles: a model for nuclear organelles. Nature Reviews. Molecular Cell Biology. 4: 605-12. PMID 12923522 DOI: 10.1038/Nrm1172  1
2003 Narita M, N?nez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell. 113: 703-16. PMID 12809602 DOI: 10.1016/S0092-8674(03)00401-X  1
2003 Janicki SM, Spector DL. Nuclear choreography: interpretations from living cells. Current Opinion in Cell Biology. 15: 149-57. PMID 12648670 DOI: 10.1016/S0955-0674(03)00012-7  1
2003 Prasanth KV, Sacco-Bubulya PA, Prasanth SG, Spector DL. Sequential entry of components of the gene expression machinery into daughter nuclei. Molecular Biology of the Cell. 14: 1043-57. PMID 12631722 DOI: 10.1091/Mbc.E02-10-0669  1
2003 Spector DL, Gasser SM. A molecular dissection of nuclear function. Conference on the dynamic nucleus: questions and implications. Embo Reports. 4: 18-23. PMID 12524514 DOI: 10.1038/Sj.Embor.Embor701  1
2002 Sacco-Bubulya P, Spector DL. Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing. The Journal of Cell Biology. 156: 425-36. PMID 11827980 DOI: 10.1083/Jcb.200107017  1
2002 Muratani M, Gerlich D, Janicki SM, Gebhard M, Eils R, Spector DL. Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus. Nature Cell Biology. 4: 106-10. PMID 11753375 DOI: 10.1038/Ncb740  1
2002 Boggs BA, Cheung P, Heard E, Spector DL, Chinault AC, Allis CD. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nature Genetics. 30: 73-6. PMID 11740495 DOI: 10.1038/Ng787  1
2001 Heard E, Rougeulle C, Arnaud D, Avner P, Allis CD, Spector DL. Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Cell. 107: 727-38. PMID 11747809 DOI: 10.1016/S0092-8674(01)00598-0  1
2001 Spector DL. Nuclear domains. Journal of Cell Science. 114: 2891-3. PMID 11686292  1
2000 Tsukamoto T, Hashiguchi N, Janicki SM, Tumbar T, Belmont AS, Spector DL. Visualization of gene activity in living cells. Nature Cell Biology. 2: 871-8. PMID 11146650 DOI: 10.1038/35046510  1
2000 Mintz PJ, Spector DL. Compartmentalization of RNA processing factors within nuclear speckles. Journal of Structural Biology. 129: 241-51. PMID 10806074 DOI: 10.1006/Jsbi.2000.4213  1
2000 Raska I, Spector DL. An "Eclipse" over the cell nucleus at the turn of the century Journal of Structural Biology. 129: 101. PMID 10806062 DOI: 10.1006/Jsbi.2000.4257  1
2000 Eils R, Gerlich D, Tvaruskó W, Spector DL, Misteli T. Quantitative imaging of pre-mRNA splicing factors in living cells. Molecular Biology of the Cell. 11: 413-8. PMID 10679003 DOI: 10.1091/Mbc.11.2.413  1
2000 Lorenz P, Misteli T, Baker BF, Bennett CF, Spector DL. Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides. Nucleic Acids Research. 28: 582-92. PMID 10606658 DOI: 10.1093/Nar/28.2.582  1
2000 Spector DL. Studying Subnuclear Dynamics in Living Cells Microscopy and Microanalysis. 6: 836-837. DOI: 10.1017/S1431927600036679  0.01
1999 Spector DL, Misteli T. 8 dynamics of gene expression The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 47: 1644C-1644. PMID 10567455  1
1999 Mintz PJ, Patterson SD, Neuwald AF, Spahr CS, Spector DL. Purification and biochemical characterization of interchromatin granule clusters. The Embo Journal. 18: 4308-20. PMID 10428969 DOI: 10.1093/Emboj/18.15.4308  1
1999 Misteli T, Spector DL. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Molecular Cell. 3: 697-705. PMID 10394358 DOI: 10.1016/S1097-2765(01)80002-2  1
1999 Tvaruskó W, Bentele M, Misteli T, Rudolf R, Kaether C, Spector DL, Gerdes HH, Eils R. Time-resolved analysis and visualization of dynamic processes in living cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 7950-5. PMID 10393928 DOI: 10.1073/Pnas.96.14.7950  1
1998 Misteli T, Cáceres JF, Clement JQ, Krainer AR, Wilkinson MF, Spector DL. Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. The Journal of Cell Biology. 143: 297-307. PMID 9786943 DOI: 10.1083/Jcb.143.2.297  1
1998 Huang S, Deerinck TJ, Ellisman MH, Spector DL. The perinucleolar compartment and transcription. The Journal of Cell Biology. 143: 35-47. PMID 9763419 DOI: 10.1083/Jcb.143.1.35  1
1998 Misteli T, Spector DL. The cellular organization of gene expression. Current Opinion in Cell Biology. 10: 323-31. PMID 9640532 DOI: 10.1016/S0955-0674(98)80007-0  1
1998 Lorenz P, Baker BF, Bennett CF, Spector DL. Phosphorothioate antisense oligonucleotides induce the formation of nuclear bodies. Molecular Biology of the Cell. 9: 1007-23. PMID 9571236 DOI: 10.1091/Mbc.9.5.1007  1
1997 Misteli T, Spector DL. Protein phosphorylation and the nuclear organization of pre-mRNA splicing. Trends in Cell Biology. 7: 135-8. PMID 17708924 DOI: 10.1016/S0962-8924(96)20043-1  1
1997 Misteli T, Spector DL. Applications of the green fluorescent protein in cell biology and biotechnology. Nature Biotechnology. 15: 961-4. PMID 9335045 DOI: 10.1038/Nbt1097-961  1
1997 Cáceres JF, Misteli T, Screaton GR, Spector DL, Krainer AR. Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. The Journal of Cell Biology. 138: 225-38. PMID 9230067 DOI: 10.1083/Jcb.138.2.225  1
1997 Powell RD, Halsey CM, Spector DL, Kaurin SL, McCann J, Hainfeld JF. A covalent fluorescent-gold immunoprobe: simultaneous detection of a pre-mRNA splicing factor by light and electron microscopy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 45: 947-56. PMID 9212820 DOI: 10.1177/002215549704500704  1
1997 Huang S, Mayeda A, Krainer AR, Spector DL. RCC1 and nuclear organization. Molecular Biology of the Cell. 8: 1143-57. PMID 9201722 DOI: 10.1091/Mbc.8.6.1143  1
1997 Misteli T, Cáceres JF, Spector DL. The dynamics of a pre-mRNA splicing factor in living cells. Nature. 387: 523-7. PMID 9168118 DOI: 10.1038/387523A0  1
1997 Huang S, Deerinck TJ, Ellisman MH, Spector DL. The dynamic organization of the perinucleolar compartment in the cell nucleus. The Journal of Cell Biology. 137: 965-74. PMID 9166399 DOI: 10.1083/Jcb.137.5.965  1
1996 Spector DL. Nuclear organization and gene expression. Experimental Cell Research. 229: 189-97. PMID 8986596 DOI: 10.1006/Excr.1996.0358  1
1996 Misteli T, Spector DL. Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors. Molecular Biology of the Cell. 7: 1559-72. PMID 8898362 DOI: 10.1091/Mbc.7.10.1559  1
1996 Huang S, Spector DL. Dynamic organization of pre-mRNA splicing factors. Journal of Cellular Biochemistry. 62: 191-7. PMID 8844399 DOI: 10.1002/(Sici)1097-4644(199608)62:2<191::Aid-Jcb7>3.0.Co;2-N  1
1996 Tani T, Derby RJ, Hiraoka Y, Spector DL. Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport. Molecular Biology of the Cell. 7: 173-92. PMID 8741848  1
1996 Huang S, Spector DL. Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription. The Journal of Cell Biology. 133: 719-32. PMID 8666659 DOI: 10.1083/Jcb.133.4.719  1
1995 Tani T, Derby RJ, Hiraoka Y, Spector DL. Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport. Molecular Biology of the Cell. 6: 1515-34. PMID 8589453 DOI: 10.1091/Mbc.6.11.1515  1
1994 O'Keefe RT, Mayeda A, Sadowski CL, Krainer AR, Spector DL. Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. The Journal of Cell Biology. 124: 249-60. PMID 8294510 DOI: 10.1083/Jcb.124.3.249  1
1994 Jiménez-García LF, Segura-Valdez ML, Ochs RL, Rothblum LI, Hannan R, Spector DL. Nucleologenesis: U3 snRNA-containing prenucleolar bodies move to sites of active pre-rRNA transcription after mitosis. Molecular Biology of the Cell. 5: 955-66. PMID 7841523 DOI: 10.1091/Mbc.5.9.955  1
1994 Deerinck TJ, Martone ME, Lev-Ram V, Green DP, Tsien RY, Spector DL, Huang S, Ellisman MH. Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy. The Journal of Cell Biology. 126: 901-10. PMID 7519623 DOI: 10.1083/Jcb.126.4.901  1
1994 Huang S, Deerinck TJ, Ellisman MH, Spector DL. In vivo analysis of the stability and transport of nuclear poly(A)+ RNA. The Journal of Cell Biology. 126: 877-99. PMID 7519622 DOI: 10.1083/Jcb.126.4.877  1
1994 Spector DL. Cycling splicing factors Nature. 369: 604. DOI: 10.1038/369604A0  1
1994 Huang S, Deerinck TJ, Ellisman MH, Spector DL. Nuclear organization of pre-mRNA splicing factors and their substrates Proceedings - Annual Meeting, Microscopy Society of America. 18-19.  1
1993 Jiménez-García LF, Spector DL. In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism Cell. 73: 47-59. PMID 8462102 DOI: 10.1016/0092-8674(93)90159-N  1
1993 Spector DL. Nuclear organization of pre-mRNA processing Current Opinion in Cell Biology. 5: 442-447. PMID 8352961 DOI: 10.1016/0955-0674(93)90009-F  1
1993 Spector DL. Macromolecular domains within the cell nculeus Annual Review of Cell Biology. 9: 265-315. PMID 8280462 DOI: 10.1146/Annurev.Cb.09.110193.001405  1
1993 Spector DL, Landon S, O'Keefe RT. Organization of RNA polymerase II transcription and pre-mRNA splicing within the mammalian cell nucleus Biochemical Society Transactions. 21: 918-920. PMID 8132093 DOI: 10.1042/Bst0210918  1
1993 Spector DL, O'Keefe RT, Jimenez-Garcia LF. Dynamics of transcription and pre-mRNA splicing within the mammalian cell nucleus Cold Spring Harbor Symposia On Quantitative Biology. 58: 799-805. PMID 7956094 DOI: 10.1101/Sqb.1993.058.01.087  1
1993 Jiménez-García LF, Green SR, Mathews MB, Spector DL. Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells. Journal of Cell Science. 106: 11-22. PMID 7903669  1
1992 O'Keefe RT, Henderson SC, Spector DL. Dynamic organization of DNA replication in mammalian cell nuclei: Spatially and temporally defined replication of chromosome-specific α-satellite DNA sequences Journal of Cell Biology. 116: 1095-1110. PMID 1740468 DOI: 10.1083/Jcb.116.5.1095  1
1992 Spector DL, Lark G, Huang S. Differences in snRNP localization between transformed and nontransformed cells Molecular Biology of the Cell. 3: 555-569. PMID 1535243 DOI: 10.1091/Mbc.3.5.555  1
1992 Huang S, Spector DL. U1 and U2 small nuclear RNAs are present in nuclear speckles Proceedings of the National Academy of Sciences of the United States of America. 89: 305-308. PMID 1530887 DOI: 10.1073/Pnas.89.1.305  1
1992 Romanelli MG, Mavromara-Nazos P, Spector D, Roizman B. Mutational analysis of the ICP4 binding sites in the 5' transcribed noncoding domains of the herpes simplex virus 1 UL 49.5 gamma 2 gene. Journal of Virology. 66: 4855-63. PMID 1321274 DOI: 10.1128/Jvi.66.8.4855-4863.1992  1
1992 Purves FC, Spector D, Roizman B. UL34, the target of the herpes simplex virus U(S)3 protein kinase, is a membrane protein which in its unphosphorylated state associates with novel phosphoproteins. Journal of Virology. 66: 4295-303. PMID 1318405 DOI: 10.1128/Jvi.66.7.4295-4303.1992  1
1992 Huang S, Spector DL. Will the real splicing sites please light up? Current Biology. 2: 188-190. DOI: 10.1016/0960-9822(92)90516-D  1
1991 Yu IJ, Spector DL, Bae YS, Marshak DR. Immunocytochemical localization of casein kinase II during interphase and mitosis Journal of Cell Biology. 114: 1217-1232. PMID 1894695 DOI: 10.1083/Jcb.114.6.1217  1
1991 Spector DL, Fu XD, Maniatis T. Associations between distinct pre-mRNA splicing components and the cell nucleus Embo Journal. 10: 3467-3481. PMID 1833187 DOI: 10.1002/J.1460-2075.1991.Tb04911.X  1
1991 Huang S, Spector DL. Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors Genes and Development. 5: 2288-2302. PMID 1748285 DOI: 10.1101/Gad.5.12A.2288  1
1991 Purves FC, Spector D, Roizman B. The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene. Journal of Virology. 65: 5757-64. PMID 1656069 DOI: 10.1128/Jvi.65.11.5757-5764.1991  1
1990 Potashkin JA, Derby RJ, Spector DL. Differential distribution of factors involved in pre-mRNA processing in the yeast cell nucleus. Molecular and Cellular Biology. 10: 3524-34. PMID 2192258 DOI: 10.1128/Mcb.10.7.3524  1
1990 Powers AC, Efrat S, Mojsov S, Spector D, Habener JF, Hanahan D. Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor. Diabetes. 39: 406-14. PMID 2156740 DOI: 10.2337/Diab.39.4.406  1
1990 Spector DL. Higher order nuclear organization: Three-dimensional distribution of small nuclear ribonucleoprotein particles Proceedings of the National Academy of Sciences of the United States of America. 87: 147-151. PMID 2136950 DOI: 10.1073/Pnas.87.1.147  1
1989 Conway GC, Krainer AR, Spector DL, Roberts RJ. Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing. Molecular and Cellular Biology. 9: 5273-80. PMID 2531283 DOI: 10.1128/Mcb.9.12.5273  1
1988 White E, Spector D, Welch W. Differential distribution of the adenovirus E1A proteins and colocalization of E1A with the 70-kilodalton cellular heat shock protein in infected cells Journal of Virology. 62: 4153-4166. PMID 2971821 DOI: 10.1128/Jvi.62.11.4153-4166.1988  1
1988 Efrat S, Linde S, Kofod H, Spector D, Delannoy M, Grant S, Hanahan D, Baekkeskov S. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proceedings of the National Academy of Sciences of the United States of America. 85: 9037-41. PMID 2848253 DOI: 10.1073/Pnas.85.23.9037  1
1988 Michael N, Spector D, Mavromara-Nazos P, Kristie TM, Roizman B. The DNA-binding properties of the major regulatory protein alpha 4 of herpes simplex viruses. Science (New York, N.Y.). 239: 1531-4. PMID 2832940 DOI: 10.1126/Science.2832940  1
1987 Spector DL, Watt RA, Sullivan NF. The v- and c-myc oncogene proteins colocalize in situ with small nuclear ribonucleoprotein particles Oncogene. 1: 5-12. PMID 2963988  1
1987 Scolnik PA, Hinton P, Greenblatt IM, Giuliano G, Delanoy MR, Spector DL, Pollock D. Somatic instability of carotenoid biosynthesis in the tomato ghost mutant and its effect on plastid development Planta. 171: 11-18. DOI: 10.1007/Bf00395063  1
1986 Sullivan NF, Watt RA, Delannoy MR, Green CL, Spector DL. Colocalization of the myc oncogene protein and small nuclear ribonucleoprotein particles Cold Spring Harbor Symposia On Quantitative Biology. 51: 943-947. PMID 2953548 DOI: 10.1101/Sqb.1986.051.01.107  1
1986 Smith HC, Ochs RL, Fernandez EA, Spector DL. Macromolecular domains containing nuclear protein p107 and U-snRNP protein p28: Further evidence for an in situ nuclear matrix Molecular and Cellular Biochemistry. 70: 151-168. PMID 2941679 DOI: 10.1007/Bf00229430  1
1986 Bennett CF, Spector DL, Yeoman LC. Nonhistone protein BA is a glutatione S-transferase localized to interchromatinic regions of the cell nucleus Journal of Cell Biology. 102: 600-609. PMID 2935545 DOI: 10.1083/Jcb.102.2.600  1
1986 Spector DL, Smith HC. Redistribution of U-snRNPs during mitosis Experimental Cell Research. 163: 87-94. PMID 2935418 DOI: 10.1016/0014-4827(86)90560-4  1
1985 Busch H, Ochs RL, Smith HC, Spector DL. Nuclear antigenic structures. Scandinavian Journal of Rheumatology. Supplement. 56: 10-21. PMID 3858986  1
1985 Smith HC, Spector DL, Woodcock CLF, Ochs RL, Bhorjee J. Alterations in chromatin conformation are accompanied by reorganization of nonchromatin domains that contain U-snRNP protein p28 and nuclear protein p107 Journal of Cell Biology. 101: 560-567. PMID 2991302 DOI: 10.1083/Jcb.101.2.560  1
1985 Reddy R, Henning D, Liu MH, Spector D, Busch H. Identification and characterization of a polyadenylated small RNA (s-poly A+ RNA) in dinoflagellates. Biochemical and Biophysical Research Communications. 127: 552-7. PMID 2579655 DOI: 10.1016/S0006-291X(85)80195-9  1
1984 Spector DL. Colocalization of U1 and U2 small nuclear RNPs by immunocytochemistry Biology of the Cell. 51: 109-112. PMID 6207877 DOI: 10.1111/J.1768-322X.1984.Tb00289.X  1
1984 Spector DL, Ochs RL, Busch H. Silver staining, immunofluorescence, and immunoelectron microscopic localization of nucleolar phosphoproteins B23 and C23. Chromosoma. 90: 139-48. PMID 6206987 DOI: 10.1007/Bf00292451  1
1984 Liu M, Reddy R, Henning D, Spector D, Busch H. Primary and secondary structure of dinoflagellate U5 small nuclear RNA. Nucleic Acids Research. 12: 1529-1542. PMID 6199742 DOI: 10.1093/Nar/12.3.1529  1
1983 Spector DL, Schrier WH, Busch H. Immunoelectron microscopic localization of snRNPs. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 49: 1-10. PMID 6230127 DOI: 10.1111/J.1768-322X.1984.Tb00215.X  1
1981 Spector DL, Triemer RE. Chromosome structure and mitosis in the dinoflagellates: An ultrastructural approach to an evolutionary problem Biosystems. 14: 289-298. PMID 7199946 DOI: 10.1016/0303-2647(81)90035-6  1
1981 Spector DL, Vasconcelos AC, Triemer RE. DNA duplication and chromosome structure in the Dinoflagellates Protoplasma. 105: 185-194. PMID 7194490 DOI: 10.1007/Bf01279217  1
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