Tyler Jacks - Publications

Affiliations: 
Biology Massachusetts Institute of Technology, Cambridge, MA, United States 

148 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Guimaraes PPG, Tan M, Tammela T, Wu K, Chung A, Oberli M, Wang K, Spektor R, Riley RS, Viana CTR, Jacks T, Langer R, Mitchell MJ. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30290244 DOI: 10.1016/j.jconrel.2018.09.025  1
2018 Lo JH, Hao L, Muzumdar MD, Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS, Hahn WC, Jacks T, Bhatia SN. iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer. Molecular Cancer Therapeutics. PMID 30097486 DOI: 10.1158/1535-7163.MCT-17-1090  1
2018 Dayton TL, Gocheva V, Miller KM, Bhutkar A, Lewis CA, Bronson RT, Vander Heiden MG, Jacks T. Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma. Cancer & Metabolism. 6: 6. PMID 29854399 DOI: 10.1186/s40170-018-0179-2  1
2018 Tao Z, Muzumdar MD, Detappe A, Huang X, Xu E, Yu Y, Mouhieddine TH, Song H, Jacks T, Ghoroghchian PP. Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer. Nano Letters. PMID 29533667 DOI: 10.1021/acs.nanolett.7b04043  1
2018 Roper J, Tammela T, Akkad A, Almeqdadi M, Santos SB, Jacks T, Yilmaz ÖH. Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. Nature Protocols. 13: 217-234. PMID 29300388 DOI: 10.1038/nprot.2017.136  1
2017 Chen PY, Muzumdar MD, Dorans KJ, Robbins RA, Bhutkar A, Del Rosario AM, Mertins P, Qiao J, Schäfer C, Gertler FB, Carr SA, Jacks T. Adaptive and reversible resistance to Kras inhibition in pancreatic cancer cells. Cancer Research. PMID 29279356 DOI: 10.1158/0008-5472.CAN-17-2129  1
2017 Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, ... ... Jacks T, et al. Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nature Biotechnology. 35: 1211. PMID 29220013 DOI: 10.1038/nbt1217-1211a  1
2017 Muzumdar MD, Chen PY, Dorans KJ, Chung KM, Bhutkar A, Hong E, Noll EM, Sprick MR, Trumpp A, Jacks T. Survival of pancreatic cancer cells lacking KRAS function. Nature Communications. 8: 1090. PMID 29061961 DOI: 10.1038/s41467-017-00942-5  1
2017 Lee JH, Tammela T, Hofree M, Choi J, Marjanovic ND, Han S, Canner D, Wu K, Paschini M, Bhang DH, Jacks T, Regev A, Kim CF. Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6. Cell. 170: 1149-1163.e12. PMID 28886383 DOI: 10.1016/j.cell.2017.07.028  1
2017 Gocheva V, Naba A, Bhutkar A, Guardia T, Miller KM, Li CM, Dayton TL, Sanchez-Rivera FJ, Kim-Kiselak C, Jailkhani N, Winslow MM, Del Rosario A, Hynes RO, Jacks T. Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652369 DOI: 10.1073/pnas.1707054114  1
2017 Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz ÖH, Xue W, ... ... Jacks T, et al. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Nature. PMID 28489818 DOI: 10.1038/nature22334  1
2017 Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, ... ... Jacks T, et al. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nature Biotechnology. PMID 28459449 DOI: 10.1038/nbt.3836  1
2016 McFadden DG, Politi K, Bhutkar A, Chen FK, Song X, Pirun M, Santiago PM, Kim-Kiselak C, Platt JT, Lee E, Hodges E, Rosebrock AP, Bronson RT, Socci ND, Hannon GJ, ... Jacks T, et al. Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27702896 DOI: 10.1073/pnas.1613601113  1
2016 Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, et al. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science (New York, N.Y.). 353: 1161-5. PMID 27609895 DOI: 10.1126/science.aaf5171  1
2016 Muzumdar MD, Dorans KJ, Chung KM, Robbins R, Tammela T, Gocheva V, Li CM, Jacks T. Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers. Nature Communications. 7: 12685. PMID 27585860 DOI: 10.1038/ncomms12685  1
2016 Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P. Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. Cell. 165: 896-909. PMID 27153497 DOI: 10.1016/j.cell.2016.04.039  1
2016 Dayton TL, Gocheva V, Miller KM, Israelsen WJ, Bhutkar A, Clish CB, Davidson SM, Luengo A, Bronson RT, Jacks T, Vander Heiden MG. Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Genes & Development. PMID 27125672 DOI: 10.1101/gad.278549.116  1
2016 Akama-Garren EH, Joshi NS, Tammela T, Chang GP, Wagner BL, Lee DY, Rideout Iii WM, Papagiannakopoulos T, Xue W, Jacks T. A Modular Assembly Platform for Rapid Generation of DNA Constructs. Scientific Reports. 6: 16836. PMID 26887506 DOI: 10.1038/srep16836  1
2015 Dimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong RM, Miller KM, Bendor J, Jacks T. Stromal expression of miR-143/145 promotes neoangiogenesis in lung cancer development. Cancer Discovery. PMID 26586766 DOI: 10.1158/2159-8290.CD-15-0854  1
2015 Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, ... ... Jacks T, et al. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nature Medicine. PMID 26390243 DOI: 10.1038/nm.3952  0.68
2015 Li CM, Gocheva V, Oudin MJ, Bhutkar A, Wang SY, Date SR, Ng SR, Whittaker CA, Bronson RT, Snyder EL, Gertler FB, Jacks T. Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis. Genes & Development. 29: 1850-62. PMID 26341558 DOI: 10.1101/gad.267393.115  1
2015 Joshi NS, Akama-Garren EH, Lu Y, Lee DY, Chang GP, Li A, DuPage M, Tammela T, Kerper NR, Farago AF, Robbins R, Crowley DM, Bronson RT, Jacks T. Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses. Immunity. 43: 579-90. PMID 26341400 DOI: 10.1016/j.immuni.2015.08.006  1
2015 Li Y, Park AI, Mou H, Colpan C, Bizhanova A, Akama-Garren E, Joshi N, Hendrickson EA, Feldser D, Yin H, Anderson DG, Jacks T, Weng Z, Xue W. A versatile reporter system for CRISPR-mediated chromosomal rearrangements. Genome Biology. 16: 111. PMID 26018130 DOI: 10.1186/s13059-015-0680-7  1
2015 Khan OF, Zaia EW, Jhunjhunwala S, Xue W, Cai W, Yun DS, Barnes CM, Dahlman JE, Dong Y, Pelet JM, Webber MJ, Tsosie JK, Jacks TE, Langer R, Anderson DG. Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature. Nano Letters. 15: 3008-16. PMID 25789998 DOI: 10.1021/nl5048972  1
2015 Faber AC, Farago AF, Costa C, Dastur A, Gomez-Caraballo M, Robbins R, Wagner BL, Rideout WM, Jakubik CT, Ham J, Edelman EJ, Ebi H, Yeo AT, Hata AN, Song Y, ... ... Jacks T, et al. Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 112: E1288-96. PMID 25737542 DOI: 10.1073/pnas.1411848112  1
2015 Gazdar AF, Savage TK, Johnson JE, Berns A, Sage J, Linnoila RI, MacPherson D, McFadden DG, Farago A, Jacks T, Travis WD, Brambilla E. The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 10: 553-64. PMID 25675280 DOI: 10.1097/JTO.0000000000000459  1
2014 Sánchez-Rivera FJ, Papagiannakopoulos T, Romero R, Tammela T, Bauer MR, Bhutkar A, Joshi NS, Subbaraj L, Bronson RT, Xue W, Jacks T. Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Nature. 516: 428-31. PMID 25337879 DOI: 10.1038/nature13906  1
2014 Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 514: 380-4. PMID 25119044 DOI: 10.1038/nature13589  1
2014 Xue W, Dahlman JE, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, ... Jacks T, et al. Small RNA combination therapy for lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: E3553-61. PMID 25114235 DOI: 10.1073/pnas.1412686111  1
2014 Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, Schinzel AC, Sood S, Rosenbluh J, Kim JW, Zwang Y, Roberts TM, Root DE, Jacks T, Hahn WC. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell. 158: 171-84. PMID 24954536 DOI: 10.1016/j.cell.2014.06.004  1
2014 Chiou SH, Kim-Kiselak C, Risca VI, Heimann MK, Chuang CH, Burds AA, Greenleaf WJ, Jacks TE, Feldser DM, Winslow MM. A conditional system to specifically link disruption of protein-coding function with reporter expression in mice. Cell Reports. 7: 2078-86. PMID 24931605 DOI: 10.1016/j.celrep.2014.05.031  1
2014 Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discovery. 4: 914-27. PMID 24875857 DOI: 10.1158/2159-8290.CD-14-0363  1
2014 Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T. LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Molecular Cell. 54: 777-90. PMID 24857549 DOI: 10.1016/j.molcel.2014.04.025  1
2014 McFadden DG, Vernon A, Santiago PM, Martinez-McFaline R, Bhutkar A, Crowley DM, McMahon M, Sadow PM, Jacks T. p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: E1600-9. PMID 24711431 DOI: 10.1073/pnas.1404357111  1
2014 Gierut JJ, Jacks TE, Haigis KM. Whole-mount X-Gal staining of mouse tissues. Cold Spring Harbor Protocols. 2014: 417-9. PMID 24692489 DOI: 10.1101/pdb.prot073452  0.72
2014 Gierut JJ, Jacks TE, Haigis KM. Strategies to achieve conditional gene mutation in mice. Cold Spring Harbor Protocols. 2014: 339-49. PMID 24692485 DOI: 10.1101/pdb.top069807  0.72
2014 Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nature Biotechnology. 32: 551-3. PMID 24681508 DOI: 10.1038/nbt.2884  1
2014 McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Stewart C, Carter SL, Cibulskis K, Bhutkar A, McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, ... ... Jacks T, et al. Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. Cell. 156: 1298-311. PMID 24630729 DOI: 10.1016/j.cell.2014.02.031  1
2014 Gierut JJ, Jacks TE, Haigis KM. In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation. Cold Spring Harbor Protocols. 2014: 307-9. PMID 24591689 DOI: 10.1101/pdb.prot073445  0.72
2014 Gierut JJ, Jacks TE, Haigis KM. Producing and concentrating lenti-Cre for mouse infections. Cold Spring Harbor Protocols. 2014: 304-6. PMID 24591688 DOI: 10.1101/pdb.prot073437  0.72
2014 Vanden Borre P, McFadden DG, Gunda V, Sadow PM, Varmeh S, Bernasconi M, Jacks T, Parangi S. The next generation of orthotopic thyroid cancer models: immunocompetent orthotopic mouse models of BRAF V600E-positive papillary and anaplastic thyroid carcinoma. Thyroid : Official Journal of the American Thyroid Association. 24: 705-14. PMID 24295207 DOI: 10.1089/thy.2013.0483  1
2013 Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB. A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response InVivo Cell Reports. 5: 868-877. PMID 24239348 DOI: 10.1016/j.celrep.2013.10.025  1
2013 Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, ... Jacks T, et al. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 155: 397-409. PMID 24120138 DOI: 10.1016/j.cell.2013.09.025  1
2013 Li CM, Chen G, Dayton TL, Kim-Kiselak C, Hoersch S, Whittaker CA, Bronson RT, Beer DG, Winslow MM, Jacks T. Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma. Genes & Development. 27: 1557-67. PMID 23873940 DOI: 10.1101/gad.222745.113  1
2013 Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, Snyder E, Santanam U, Dipaola RS, Jacks T, Rabinowitz JD, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes & Development. 27: 1447-61. PMID 23824538 DOI: 10.1101/gad.219642.113  1
2013 Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon K. Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discovery. 3: 993-1001. PMID 23733505 DOI: 10.1158/2159-8290.CD-13-0096  0.72
2013 Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, Moon JY, Jacks T, Sabatini DM, Kalaany NY. Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. Cancer Discovery. 3: 908-21. PMID 23719831 DOI: 10.1158/2159-8290.CD-12-0507  1
2013 Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... ... Jacks T, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/srep01449  1
2013 Byun S, Son S, Amodei D, Cermak N, Shaw J, Kang JH, Hecht VC, Winslow MM, Jacks T, Mallick P, Manalis SR. Characterizing deformability and surface friction of cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 7580-5. PMID 23610435 DOI: 10.1073/pnas.1218806110  1
2013 Snyder EL, Watanabe H, Magendantz M, Hoersch S, Chen TA, Wang DG, Crowley D, Whittaker CA, Meyerson M, Kimura S, Jacks T. Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma. Molecular Cell. 50: 185-99. PMID 23523371 DOI: 10.1016/j.molcel.2013.02.018  1
2013 Joshi NS, Jacks T. Immunology. Guilty by association. Science (New York, N.Y.). 339: 1160-1. PMID 23471395 DOI: 10.1126/science.1235528  1
2013 Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Izzo F, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, ... ... Jacks T, et al. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes & Development. 27: 197-210. PMID 23322301 DOI: 10.1101/gad.203208.112  1
2012 Reticker-Flynn NE, Malta DF, Winslow MM, Lamar JM, Xu MJ, Underhill GH, Hynes RO, Jacks TE, Bhatia SN. A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nature Communications. 3: 1122. PMID 23047680 DOI: 10.1038/ncomms2128  1
2012 Ravi A, Gurtan AM, Kumar MS, Bhutkar A, Chin C, Lu V, Lees JA, Jacks T, Sharp PA. Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Cancer Cell. 21: 848-55. PMID 22698408 DOI: 10.1016/j.ccr.2012.04.037  1
2012 DuPage M, Mazumdar C, Schmidt LM, Cheung AF, Jacks T. Expression of tumour-specific antigens underlies cancer immunoediting. Nature. 482: 405-9. PMID 22318517 DOI: 10.1038/nature10803  1
2012 Itzkovitz S, Blat IC, Jacks T, Clevers H, van Oudenaarden A. Optimality in the development of intestinal crypts. Cell. 148: 608-19. PMID 22304925 DOI: 10.1016/j.cell.2011.12.025  1
2012 Schroeder A, Heller DA, Winslow MM, Dahlman JE, Pratt GW, Langer R, Jacks T, Anderson DG. Treating metastatic cancer with nanotechnology. Nature Reviews. Cancer. 12: 39-50. PMID 22193407 DOI: 10.1038/nrc3180  1
2012 Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, Lees J, Jacks T, Clevers H, van Oudenaarden A. Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nature Cell Biology. 14: 106-14. PMID 22119784 DOI: 10.1038/ncb2384  1
2011 Xue W, Meylan E, Oliver TG, Feldser DM, Winslow MM, Bronson R, Jacks T. Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma. Cancer Discovery. 1: 236-47. PMID 21874163 DOI: 10.1158/2159-8290.CD-11-0073  1
2011 To MD, Quigley DA, Mao JH, Del Rosario R, Hsu J, Hodgson G, Jacks T, Balmain A. Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer. Molecular Cancer Research : McR. 9: 1339-45. PMID 21807965 DOI: 10.1158/1541-7786.MCR-11-0219  1
2011 Dooley AL, Winslow MM, Chiang DY, Banerji S, Stransky N, Dayton TL, Snyder EL, Senna S, Whittaker CA, Bronson RT, Crowley D, Barretina J, Garraway L, Meyerson M, Jacks T. Nuclear factor I/B is an oncogene in small cell lung cancer. Genes & Development. 25: 1470-5. PMID 21764851 DOI: 10.1101/gad.2046711  1
2011 Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T. Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Molecular Cell. 43: 57-71. PMID 21726810 DOI: 10.1016/j.molcel.2011.06.012  1
2011 Shaw AT, Winslow MM, Magendantz M, Ouyang C, Dowdle J, Subramanian A, Lewis TA, Maglathin RL, Tolliday N, Jacks T. Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 108: 8773-8. PMID 21555567 DOI: 10.1073/pnas.1105941108  1
2011 Young NP, Crowley D, Jacks T. Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis. Cancer Research. 71: 4040-7. PMID 21512139 DOI: 10.1158/0008-5472.CAN-10-4563  1
2011 Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, Chiang DY, Meyerson M, ... Jacks T, et al. Suppression of lung adenocarcinoma progression by Nkx2-1. Nature. 473: 101-4. PMID 21471965 DOI: 10.1038/nature09881  1
2011 Cellurale C, Sabio G, Kennedy NJ, Das M, Barlow M, Sandy P, Jacks T, Davis RJ. Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation. Molecular and Cellular Biology. 31: 1565-76. PMID 21282468 DOI: 10.1128/MCB.01122-10  1
2011 DuPage M, Cheung AF, Mazumdar C, Winslow MM, Bronson R, Schmidt LM, Crowley D, Chen J, Jacks T. Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. Cancer Cell. 19: 72-85. PMID 21251614 DOI: 10.1016/j.ccr.2010.11.011  1
2011 Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 117: 2022-32. PMID 21163920 DOI: 10.1182/blood-2010-04-280750  1
2010 Feldser DM, Kostova KK, Winslow MM, Taylor SE, Cashman C, Whittaker CA, Sanchez-Rivera FJ, Resnick R, Bronson R, Hemann MT, Jacks T. Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature. 468: 572-5. PMID 21107428 DOI: 10.1038/nature09535  1
2010 Doles J, Oliver TG, Cameron ER, Hsu G, Jacks T, Walker GC, Hemann MT. Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. 107: 20786-91. PMID 21068376 DOI: 10.1073/pnas.1011409107  1
2010 Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O, Amit I, Rabani M, Attardi LD, Regev A, Lander ES, Jacks T, Rinn JL. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell. 142: 409-19. PMID 20673990 DOI: 10.1016/j.cell.2010.06.040  1
2010 Mazumdar J, Hickey MM, Pant DK, Durham AC, Sweet-Cordero A, Vachani A, Jacks T, Chodosh LA, Kissil JL, Simon MC, Keith B. HIF-2alpha deletion promotes Kras-driven lung tumor development. Proceedings of the National Academy of Sciences of the United States of America. 107: 14182-7. PMID 20660313 DOI: 10.1073/pnas.1001296107  1
2010 Young NP, Jacks T. Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. Proceedings of the National Academy of Sciences of the United States of America. 107: 10184-9. PMID 20479239 DOI: 10.1073/pnas.1004796107  1
2010 Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Research. 70: 3843-50. PMID 20406974 DOI: 10.1158/0008-5472.CAN-09-3421  1
2010 Oliver TG, Mercer KL, Sayles LC, Burke JR, Mendus D, Lovejoy KS, Cheng MH, Subramanian A, Mu D, Powers S, Crowley D, Bronson RT, Whittaker CA, Bhutkar A, Lippard SJ, ... ... Jacks T, et al. Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes & Development. 24: 837-52. PMID 20395368 DOI: 10.1101/gad.1897010  1
2010 Zhou Y, Rideout WM, Zi T, Bressel A, Reddypalli S, Rancourt R, Woo JK, Horner JW, Chin L, Chiu MI, Bosenberg M, Jacks T, Clark SC, Depinho RA, Robinson MO, et al. Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas. Nature Biotechnology. 28: 71-8. PMID 20023657 DOI: 10.1038/nbt.1595  1
2010 Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, ... ... Jacks T, et al. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (New York, N.Y.). 327: 593-6. PMID 20019247 DOI: 10.1126/science.1166202  1
2010 Cheung AF, Carter AM, Kostova KK, Woodruff JF, Crowley D, Bronson RT, Haigis KM, Jacks T. Complete deletion of Apc results in severe polyposis in mice. Oncogene. 29: 1857-64. PMID 20010873 DOI: 10.1038/onc.2009.457  1
2009 Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG. Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. Plos One. 4: e8075. PMID 19956606 DOI: 10.1371/journal.pone.0008075  1
2009 Kumar MS, Pester RE, Chen CY, Lane K, Chin C, Lu J, Kirsch DG, Golub TR, Jacks T. Dicer1 functions as a haploinsufficient tumor suppressor. Genes & Development. 23: 2700-4. PMID 19903759 DOI: 10.1101/gad.1848209  1
2009 Gidekel Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Vasile E, DePinho RA, Jacks T. Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell. 16: 379-89. PMID 19878870 DOI: 10.1016/j.ccr.2009.09.027  1
2009 Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, ... ... Jacks T, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 462: 108-12. PMID 19847166 DOI: 10.1038/nature08460  1
2009 Meylan E, Dooley AL, Feldser DM, Shen L, Turk E, Ouyang C, Jacks T. Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature. 462: 104-7. PMID 19847165 DOI: 10.1038/nature08462  1
2009 Lin YL, Sengupta S, Gurdziel K, Bell GW, Jacks T, Flores ER. p63 and p73 transcriptionally regulate genes involved in DNA repair. Plos Genetics. 5: e1000680. PMID 19816568 DOI: 10.1371/journal.pgen.1000680  1
2009 Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, ... ... Jacks T, et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 16: 21-32. PMID 19573809 DOI: 10.1016/j.ccr.2009.04.012  1
2009 Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, et al. Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. International Journal of Radiation Oncology, Biology, Physics. 74: 1207-16. PMID 19545786 DOI: 10.1016/j.ijrobp.2009.02.052  1
2009 Scholl C, Fröhling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, ... Jacks T, et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell. 137: 821-34. PMID 19490892 DOI: 10.1016/j.cell.2009.03.017  1
2009 Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, Cabili MN, Jaenisch R, Mikkelsen TS, Jacks T, Hacohen N, et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature. 458: 223-7. PMID 19182780 DOI: 10.1038/nature07672  1
2008 Cheung AF, Dupage MJ, Dong HK, Chen J, Jacks T. Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer. Cancer Research. 68: 9459-68. PMID 19010921 DOI: 10.1158/0008-5472.CAN-08-2634  1
2008 Godar S, Ince TA, Bell GW, Feldser D, Donaher JL, Bergh J, Liu A, Miu K, Watnick RS, Reinhardt F, McAllister SS, Jacks T, Weinberg RA. Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell. 134: 62-73. PMID 18614011 DOI: 10.1016/j.cell.2008.06.006  1
2008 Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, et al. A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biology. 9: R93. PMID 18522751 DOI: 10.1186/gb-2008-9-6-r93  1
2008 Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nature Genetics. 40: 600-8. PMID 18372904 DOI: 10.1038/ng.115  1
2008 Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 132: 875-86. PMID 18329372 DOI: 10.1016/j.cell.2008.02.019  1
2008 Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA, Jacks T. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proceedings of the National Academy of Sciences of the United States of America. 105: 3903-8. PMID 18308936 DOI: 10.1073/pnas.0712321105  1
2007 Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T. Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Research. 67: 8089-94. PMID 17804720 DOI: 10.1158/0008-5472.CAN-07-2300  1
2007 Pandey J, Umphress SM, Kang Y, Angdisen J, Naumova A, Mercer KL, Jacks T, Jakowlew SB. Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency. Carcinogenesis. 28: 2589-96. PMID 17690114 DOI: 10.1093/carcin/bgm136  1
2007 Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, ... ... Jacks T, et al. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nature Medicine. 13: 992-7. PMID 17676052 DOI: 10.1038/nm1602  1
2007 Wijnhoven SWP, Speksnijder EN, Liu X, Zwart E, VanOostrom CTM, Beems RB, Hoogervorst EM, Schaap MM, Attardi LD, Jacks T, Van Steeg H, Jonkers J, De Vries A. Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage Cancer Research. 67: 4648-4656. PMID 17510390 DOI: 10.1158/0008-5472.CAN-06-4681  1
2007 Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nature Genetics. 39: 673-7. PMID 17401365 DOI: 10.1038/ng2003  1
2007 Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch R, Jacks T. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes & Development. 21: 694-707. PMID 17369402 DOI: 10.1101/gad.1526207  1
2007 McLaughlin ME, Kruger GM, Slocum KL, Crowley D, Michaud NA, Huang J, Magendantz M, Jacks T. The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. Proceedings of the National Academy of Sciences of the United States of America. 104: 3261-6. PMID 17360635 DOI: 10.1073/pnas.0700044104  1
2007 Zhang J, Liu Y, Beard C, Tuveson DA, Jaenisch R, Jacks TE, Lodish HF. Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways. Blood. 109: 5238-41. PMID 17317860 DOI: 10.1182/blood-2006-09-047050  1
2007 Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T. Restoration of p53 function leads to tumour regression in vivo. Nature. 445: 661-5. PMID 17251932 DOI: 10.1038/nature05541  1
2007 Keller JW, Haigis KM, Franklin JL, Whitehead RH, Jacks T, Coffey RJ. Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex. Oncogene. 26: 3051-9. PMID 17130841 DOI: 10.1038/sj.onc.1210103  1
2006 Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Research. 66: 7473-81. PMID 16885344 DOI: 10.1158/0008-5472.CAN-06-1193  1
2006 To MD, Perez-Losada J, Mao JH, Hsu J, Jacks T, Balmain A. A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nature Genetics. 38: 926-30. PMID 16823377 DOI: 10.1038/ng1836  1
2006 Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood. 108: 2041-4. PMID 16720837 DOI: 10.1182/blood-2006-01-013490  1
2006 Tuveson DA, Zhu L, Gopinathan A, Willis NA, Kachatrian L, Grochow R, Pin CL, Mitin NY, Taparowsky EJ, Gimotty PA, Hruban RH, Jacks T, Konieczny SF. Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Research. 66: 242-7. PMID 16397237 DOI: 10.1158/0008-5472.CAN-05-2305  1
2006 Haigis K, Sage J, Glickman J, Shafer S, Jacks T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. The Journal of Biological Chemistry. 281: 638-47. PMID 16258171 DOI: 10.1074/jbc.M509053200  0.56
2005 Jackson EL, Olive KP, Tuveson DA, Bronson R, Crowley D, Brown M, Jacks T. The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Research. 65: 10280-8. PMID 16288016 DOI: 10.1158/0008-5472.CAN-05-2193  1
2005 Wijnhoven SW, Zwart E, Speksnijder EN, Beems RB, Olive KP, Tuveson DA, Jonkers J, Schaap MM, van den Berg J, Jacks T, van Steeg H, de Vries A. Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development. Cancer Research. 65: 8166-73. PMID 16166291 DOI: 10.1158/0008-5472.CAN-05-1650  1
2004 Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 119: 847-60. PMID 15607980 DOI: 10.1016/j.cell.2004.11.004  1
2004 Spike BT, Dirlam A, Dibling BC, Marvin J, Williams BO, Jacks T, Macleod KF. The Rb tumor suppressor is required for stress erythropoiesis. The Embo Journal. 23: 4319-29. PMID 15457215 DOI: 10.1038/sj.emboj.7600432  1
2004 Bruins W, Zwart E, Attardi LD, Iwakuma T, Hoogervorst EM, Beems RB, Miranda B, Van Oostrom CTM, Van Den Berg J, Van Den Aardweg GJ, Lozano G, Van Steeg H, Jacks T, De Vries A. Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389 Molecular and Cellular Biology. 24: 8884-8894. PMID 15456863 DOI: 10.1128/MCB.24.20.8884-8894.2004  1
2004 MacPherson D, Sage J, Kim T, Ho D, McLaughlin ME, Jacks T. Cell type-specific effects of Rb deletion in the murine retina. Genes & Development. 18: 1681-94. PMID 15231717 DOI: 10.1101/gad.1203304  1
2004 Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, ... ... Jacks T, et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 5: 375-87. PMID 15093544 DOI: 10.1016/S1535-6108(04)00085-6  1
2004 Mayhew CN, Perkin LM, Zhang X, Sage J, Jacks T, Knudsen ES. Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents. Oncogene. 23: 4107-20. PMID 15064736 DOI: 10.1038/sj.onc.1207503  0.56
2004 Chan IT, Kutok JL, Williams IR, Cohen S, Kelly L, Shigematsu H, Johnson L, Akashi K, Tuveson DA, Jacks T, Gilliland DG. Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. The Journal of Clinical Investigation. 113: 528-38. PMID 14966562 DOI: 10.1172/JCI20476  1
2004 Attardi LD, De Vries A, Jacks T. Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer Oncogene. 23: 973-980. PMID 14749764 DOI: 10.1038/sj.onc.1207026  1
2004 Bosco EE, Mayhew CN, Hennigan RF, Sage J, Jacks T, Knudsen ES. RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult Nucleic Acids Research. 32: 25-34. PMID 14704340 DOI: 10.1093/nar/gkg919  1
2004 Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proceedings of the National Academy of Sciences of the United States of America. 101: 597-602. PMID 14699048 DOI: 10.1073/pnas.0307203101  1
2003 Reczek EE, Flores ER, Tsay AS, Attardi LD, Jacks T. Multiple Response Elements and Differential p53 Binding Control Perp Expression during Apoptosis Molecular Cancer Research. 1: 1048-1057. PMID 14707288  1
2003 Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, ... Jacks T, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 4: 437-50. PMID 14706336 DOI: 10.1016/S1535-6108(03)00309-X  1
2003 Balsitis SJ, Sage J, Duensing S, Münger K, Jacks T, Lambert PF. Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo. Molecular and Cellular Biology. 23: 9094-103. PMID 14645521 DOI: 10.1128/MCB.23.24.9094-9103.2003  1
2003 Ihrie RA, Reczek E, Horner JS, Khachatrian L, Sage J, Jacks T, Attardi LD. Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types Current Biology. 13: 1985-1990. PMID 14614825 DOI: 10.1016/j.cub.2003.10.055  1
2003 Sage J, Miller AL, Pérez-Mancera PA, Wysocki JM, Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 424: 223-8. PMID 12853964 DOI: 10.1038/nature01764  0.56
2002 Jacks T, Weinberg RA. Taking the study of cancer cell survival to a new dimension. Cell. 111: 923-5. PMID 12507419 DOI: 10.1016/S0092-8674(02)01229-1  1
2002 Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass CK. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell. 109: 169-80. PMID 12007404 DOI: 10.1016/S0092-8674(02)00714-6  1
2002 Yang H, Williams BO, Hinds PW, Shih TS, Jacks T, Bronson RT, Livingston DM. Tumor suppression by a severely truncated species of retinoblastoma protein Molecular and Cellular Biology. 22: 3103-3110. PMID 11940667 DOI: 10.1128/MCB.22.9.3103-3110.2002  1
2002 de Vries A, Flores ER, Miranda B, Hsieh HM, van Oostrom CT, Sage J, Jacks T. Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proceedings of the National Academy of Sciences of the United States of America. 99: 2948-53. PMID 11867759 DOI: 10.1073/pnas.052713099  1
2002 Kim TJ, Cariappa A, Iacomini J, Tang M, Shih S, Bernards A, Jacks T, Pillai S. Defective proliferative responses in B lymphocytes and thymocytes that lack neurofibromin Molecular Immunology. 38: 701-708. PMID 11858825 DOI: 10.1016/S0161-5890(01)00101-8  1
2002 Tuveson DA, Jacks T. Technologically advanced cancer modeling in mice. Current Opinion in Genetics & Development. 12: 105-10. PMID 11790563 DOI: 10.1016/S0959-437X(01)00272-6  1
1998 Jacks T, Weinberg RA. The expanding role of cell cycle regulators Science. 280: 1035-1036. PMID 9616080 DOI: 10.1126/science.280.5366.1035  1
1997 Jones JM, Attardi L, Godley LA, Laucirica R, Medina D, Jacks T, Varmus HE, Donehower LA. Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 8: 829-38. PMID 9269892  1
1996 Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes & Development. 10: 1633-44. PMID 8682294  1
1996 Jacks T, Weinberg RA. Cell-cycle control and its watchman. Nature. 381: 643-4. PMID 8649505 DOI: 10.1038/381643a0  0.92
1996 Herrera RE, Sah VP, Williams BO, Mäkelä TP, Weinberg RA, Jacks T. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts Molecular and Cellular Biology. 16: 2402-2407. PMID 8628308  1
1995 Tischler AS, Shih TS, Williams BO, Jacks T. Characterization of Pheochromocytomas in a Mouse Strain with a Targeted Disruptive Mutation of the Neurofibromatosis Gene Nf1. Endocrine Pathology. 6: 323-335. PMID 12114814  0.52
1994 Williams BO, Schmitt EM, Remington L, Bronson RT, Albert DM, Weinberg RA, Jacks T. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences Embo Journal. 13: 4251-4259. PMID 7925270  1
1994 Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA. Tumor spectrum analysis in p53-mutant mice Current Biology. 4: 1-7. PMID 7922305 DOI: 10.1016/S0960-9822(00)00002-6  1
1994 Jacks T, Shih TS, Schmitt EM, Bronson RT, Bernards A, Weinberg RA. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1 Nature Genetics. 7: 353-361. PMID 7920653 DOI: 10.1038/ng0794-353  1
1994 Hatakeyama M, Herrera RA, Makela T, Dowdy SF, Jacks T, Weinberg RA. The cancer cell and the cell cycle clock. Cold Spring Harbor Symposia On Quantitative Biology. 59: 1-10. PMID 7587058  1
1993 Cobrinik D, Whyte P, Peeper DS, Jacks T, Weinberg RA. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes & Development. 7: 2392-404. PMID 8253385  0.92
1992 Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA. Effects of an Rb mutation in the mouse Nature. 359: 295-300. PMID 1406933  1
1988 Jacks T, Madhani HD, Masiarz FR, Varmus HE. Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region Cell. 55: 447-458. PMID 2846182 DOI: 10.1016/0092-8674(88)90031-1  1
1988 Jacks T, Power MD, Masiarz FR, Luciw PA, Barr PJ, Varmus HE. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression Nature. 331: 280-283. PMID 2447506  1
1987 Jacks T, Townsley K, Varmus HE, Majors J. Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins Proceedings of the National Academy of Sciences of the United States of America. 84: 4298-4302. PMID 3035577  1
1985 Jacks T, Varmus HE. Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting Science. 230: 1237-1242. PMID 2416054  1
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