George Witman - Publications

Affiliations: 
Cell biology UMASS Medical School, Worcester, MA, United States 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhao L, Hou Y, McNeill NA, Witman GB. The unity and diversity of the ciliary central apparatus. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 375: 20190164. PMID 31884923 DOI: 10.1098/rstb.2019.0164  0.36
2019 Fu G, Zhao L, Dymek E, Hou Y, Song K, Phan N, Shang Z, Smith EF, Witman GB, Nicastro D. Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus. The Journal of Cell Biology. PMID 31672705 DOI: 10.1083/jcb.201906006  0.36
2019 Zhao L, Hou Y, Picariello T, Craige B, Witman GB. Proteome of the central apparatus of a ciliary axoneme. The Journal of Cell Biology. PMID 31092556 DOI: 10.1083/jcb.201902017  0.36
2019 Picariello T, Brown JM, Hou Y, Swank G, Cochran DA, King OD, Lechtreck K, Pazour GJ, Witman GB. A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia. Journal of Cell Science. PMID 30659111 DOI: 10.1242/jcs.220749  0.68
2018 Kubo T, Hou Y, Cochran DA, Witman GB, Oda T. A microtubule-dynein tethering complex regulates the axonemal inner dynein(I1). Molecular Biology of the Cell. PMID 29540525 DOI: 10.1091/mbc.E17-11-0689  0.36
2017 Hou Y, Witman GB. The N-terminus of IFT46 mediates intraflagellar transport of outer arm dynein and its cargo-adaptor ODA16. Molecular Biology of the Cell. PMID 28701346 DOI: 10.1091/mbc.E17-03-0172  0.36
2017 Brown JM, Mosley M, Montes-Berrueta D, Hou Y, Yang F, Scarbrough C, Witman GB, Wirschell M. Characterization of a new oda3 allele, oda3-6, defective in assembly of the outer dynein arm-docking complex in Chlamydomonas reinhardtii. Plos One. 12: e0173842. PMID 28291812 DOI: 10.1371/journal.pone.0173842  0.36
2016 Kubo T, Brown JM, Bellve K, Craige B, Craft JM, Fogarty K, Lechtreck KF, Witman GB. The IFT81 and IFT74 N-termini together form the major module for intraflagellar transport of tubulin. Journal of Cell Science. PMID 27068536 DOI: 10.1242/jcs.187120  0.68
2016 Schmidts M, Hou Y, Cortés CR, Mans DA, Huber C, Boldt K, Patel M, van Reeuwijk J, Plaza JM, van Beersum SE, Yap ZM, Letteboer SJ, Taylor SP, Herridge W, Johnson CA, ... ... Witman GB, et al. Corrigendum: TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nature Communications. 7: 11270. PMID 27021811 DOI: 10.1038/ncomms11270  0.36
2015 San Agustin JT, Pazour GJ, Witman GB. Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm. Molecular Biology of the Cell. 26: 4358-72. PMID 26424803 DOI: 10.1091/mbc.E15-08-0578  0.68
2015 Awata J, Song K, Lin J, King SM, Sanderson MJ, Nicastro D, Witman GB. DRC3 connects the N-DRC to dynein g to regulate flagellar waveform. Molecular Biology of the Cell. PMID 26063732 DOI: 10.1091/mbc.E15-01-0018  0.68
2015 Brown JM, Cochran DA, Craige B, Kubo T, Witman GB. Assembly of IFT Trains at the Ciliary Base Depends on IFT74. Current Biology : Cb. 25: 1583-93. PMID 26051893 DOI: 10.1016/j.cub.2015.04.060  0.68
2015 Schmidts M, Hou Y, Cortés CR, Mans DA, Huber C, Boldt K, Patel M, van Reeuwijk J, Plaza JM, van Beersum SE, Yap ZM, Letteboer SJ, Taylor SP, Herridge W, Johnson CA, ... ... Witman GB, et al. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nature Communications. 6: 7074. PMID 26044572 DOI: 10.1038/ncomms8074  0.68
2015 Damerla RR, Cui C, Gabriel GC, Liu X, Craige B, Gibbs BC, Francis R, Li Y, Chatterjee B, San Agustin JT, Eguether T, Subramanian R, Witman GB, Michaud JL, Pazour GJ, et al. Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies. Human Molecular Genetics. 24: 3994-4005. PMID 25877302 DOI: 10.1093/hmg/ddv137  0.68
2015 Hou Y, Witman GB. Dynein and intraflagellar transport. Experimental Cell Research. 334: 26-34. PMID 25725253 DOI: 10.1016/j.yexcr.2015.02.017  0.36
2015 Song K, Awata J, Tritschler D, Bower R, Witman GB, Porter ME, Nicastro D. In situ localization of N and C termini of subunits of the flagellar nexin-dynein regulatory complex (N-DRC) using SNAP tag and cryo-electron tomography. The Journal of Biological Chemistry. 290: 5341-53. PMID 25564608 DOI: 10.1074/jbc.M114.626556  0.68
2014 Craige B, Witman GB. Flipping a phosphate switch on kinesin-II to turn IFT around. Developmental Cell. 30: 492-3. PMID 25203204 DOI: 10.1016/j.devcel.2014.08.019  0.68
2014 Awata J, Takada S, Standley C, Lechtreck KF, Bellvé KD, Pazour GJ, Fogarty KE, Witman GB. NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone. Journal of Cell Science. 127: 4714-27. PMID 25150219 DOI: 10.1242/jcs.155275  0.68
2014 Owa M, Furuta A, Usukura J, Arisaka F, King SM, Witman GB, Kamiya R, Wakabayashi K. Cooperative binding of the outer arm-docking complex underlies the regular arrangement of outer arm dynein in the axoneme. Proceedings of the National Academy of Sciences of the United States of America. 111: 9461-6. PMID 24979786 DOI: 10.1073/pnas.1403101111  0.68
2014 Johnson EA, Rice SL, Preimesberger MR, Nye DB, Gilevicius L, Wenke BB, Brown JM, Witman GB, Lecomte JT. Characterization of THB1, a Chlamydomonas reinhardtii truncated hemoglobin: linkage to nitrogen metabolism and identification of lysine as the distal heme ligand. Biochemistry. 53: 4573-89. PMID 24964018 DOI: 10.1021/bi5005206  0.68
2014 Blaby IK, Blaby-Haas CE, Tourasse N, Hom EF, Lopez D, Aksoy M, Grossman A, Umen J, Dutcher S, Porter M, King S, Witman GB, Stanke M, Harris EH, Goodstein D, et al. The Chlamydomonas genome project: a decade on. Trends in Plant Science. 19: 672-80. PMID 24950814 DOI: 10.1016/j.tplants.2014.05.008  0.68
2013 Lechtreck KF, Gould TJ, Witman GB. Flagellar central pair assembly in Chlamydomonas reinhardtii. Cilia. 2: 15. PMID 24283352 DOI: 10.1186/2046-2530-2-15  0.68
2013 Craige B, Brown JM, Witman GB. Isolation of Chlamydomonas flagella. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 3.41.1-9. PMID 23728744 DOI: 10.1002/0471143030.cb0341s59  0.68
2013 Lechtreck KF, Brown JM, Sampaio JL, Craft JM, Shevchenko A, Evans JE, Witman GB. Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase. The Journal of Cell Biology. 201: 249-61. PMID 23589493 DOI: 10.1083/jcb.201207139  0.68
2013 Ludington WB, Wemmer KA, Lechtreck KF, Witman GB, Marshall WF. Avalanche-like behavior in ciliary import. Proceedings of the National Academy of Sciences of the United States of America. 110: 3925-30. PMID 23431147 DOI: 10.1073/pnas.1217354110  0.68
2012 Engel BD, Ishikawa H, Wemmer KA, Geimer S, Wakabayashi K, Hirono M, Craige B, Pazour GJ, Witman GB, Kamiya R, Marshall WF. The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function. The Journal of Cell Biology. 199: 151-67. PMID 23027906 DOI: 10.1083/jcb.201206068  0.68
2012 Brown JM, Dipetrillo CG, Smith EF, Witman GB. A FAP46 mutant provides new insights into the function and assembly of the C1d complex of the ciliary central apparatus. Journal of Cell Science. 125: 3904-13. PMID 22573824 DOI: 10.1242/jcs.107151  0.68
2011 Hom EF, Witman GB, Harris EH, Dutcher SK, Kamiya R, Mitchell DR, Pazour GJ, Porter ME, Sale WS, Wirschell M, Yagi T, King SM. A unified taxonomy for ciliary dyneins. Cytoskeleton (Hoboken, N.J.). 68: 555-65. PMID 21953912 DOI: 10.1002/cm.20533  0.68
2011 Yang Y, Cochran DA, Gargano MD, King I, Samhat NK, Burger BP, Sabourin KR, Hou Y, Awata J, Parry DA, Marshall WF, Witman GB, Lu X. Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50. Molecular Biology of the Cell. 22: 976-87. PMID 21289096 DOI: 10.1091/mbc.E10-04-0331  0.68
2010 Craige B, Tsao CC, Diener DR, Hou Y, Lechtreck KF, Rosenbaum JL, Witman GB. CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content. The Journal of Cell Biology. 190: 927-40. PMID 20819941 DOI: 10.1083/jcb.201006105  0.68
2009 Engel BD, Lechtreck KF, Sakai T, Ikebe M, Witman GB, Marshall WF. Total internal reflection fluorescence (TIRF) microscopy of Chlamydomonas flagella. Methods in Cell Biology. 93: 157-77. PMID 20409817 DOI: 10.1016/S0091-679X(08)93009-0  0.68
2009 Lechtreck KF, Sanderson MJ, Witman GB. High-speed digital imaging of ependymal cilia in the murine brain. Methods in Cell Biology. 91: 255-64. PMID 20409790 DOI: 10.1016/S0091-679X(08)91013-X  0.68
2009 Lechtreck KF, Johnson EC, Sakai T, Cochran D, Ballif BA, Rush J, Pazour GJ, Ikebe M, Witman GB. The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella. The Journal of Cell Biology. 187: 1117-32. PMID 20038682 DOI: 10.1083/jcb.200909183  0.68
2009 Wirschell M, Yang C, Yang P, Fox L, Yanagisawa HA, Kamiya R, Witman GB, Porter ME, Sale WS. IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding. Molecular Biology of the Cell. 20: 3044-54. PMID 19420136 DOI: 10.1091/mbc.E09-04-0276  0.68
2008 Lechtreck KF, Delmotte P, Robinson ML, Sanderson MJ, Witman GB. Mutations in Hydin impair ciliary motility in mice. The Journal of Cell Biology. 180: 633-43. PMID 18250199 DOI: 10.1083/jcb.200710162  0.68
2007 Huang K, Diener DR, Mitchell A, Pazour GJ, Witman GB, Rosenbaum JL. Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella. The Journal of Cell Biology. 179: 501-14. PMID 17984324 DOI: 10.1083/jcb.200704069  0.68
2007 Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Maréchal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, et al. The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science (New York, N.Y.). 318: 245-50. PMID 17932292 DOI: 10.1126/science.1143609  0.68
2007 Hou Y, Qin H, Follit JA, Pazour GJ, Rosenbaum JL, Witman GB. Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella. The Journal of Cell Biology. 176: 653-65. PMID 17312020 DOI: 10.1083/jcb.200608041  0.68
2006 Yang P, Diener DR, Yang C, Kohno T, Pazour GJ, Dienes JM, Agrin NS, King SM, Sale WS, Kamiya R, Rosenbaum JL, Witman GB. Radial spoke proteins of Chlamydomonas flagella. Journal of Cell Science. 119: 1165-74. PMID 16507594 DOI: 10.1242/jcs.02811  0.68
2006 Pazour GJ, Agrin N, Walker BL, Witman GB. Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes. Journal of Medical Genetics. 43: 62-73. PMID 15937072 DOI: 10.1136/jmg.2005.033001  0.68
2005 Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB. Cytoplasmic dynein nomenclature. The Journal of Cell Biology. 171: 411-3. PMID 16260502 DOI: 10.1083/jcb.200508078  0.68
2005 DiBella LM, Gorbatyuk O, Sakato M, Wakabayashi K, Patel-King RS, Pazour GJ, Witman GB, King SM. Differential light chain assembly influences outer arm dynein motor function. Molecular Biology of the Cell. 16: 5661-74. PMID 16195342 DOI: 10.1091/mbc.E05-08-0732  0.68
2005 Pazour GJ, Agrin N, Leszyk J, Witman GB. Proteomic analysis of a eukaryotic cilium. The Journal of Cell Biology. 170: 103-13. PMID 15998802 DOI: 10.1083/jcb.200504008  0.68
2004 Wang H, San Agustin JT, Witman GB, Kilpatrick DL. Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression. Molecular and Cellular Biology. 24: 10681-8. PMID 15572673 DOI: 10.1128/MCB.24.24.10681-10688.2004  0.68
2004 Jurczyk A, Gromley A, Redick S, San Agustin J, Witman G, Pazour GJ, Peters DJ, Doxsey S. Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. The Journal of Cell Biology. 166: 637-43. PMID 15337773 DOI: 10.1083/jcb.200405023  0.68
2004 Hou Y, Pazour GJ, Witman GB. A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport. Molecular Biology of the Cell. 15: 4382-94. PMID 15269286 DOI: 10.1091/mbc.E04-05-0377  0.68
2004 Wirschell M, Pazour G, Yoda A, Hirono M, Kamiya R, Witman GB. Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase. Molecular Biology of the Cell. 15: 2729-41. PMID 15064350 DOI: 10.1091/mbc.E03-11-0820  0.68
2003 Casey DM, Inaba K, Pazour GJ, Takada S, Wakabayashi K, Wilkerson CG, Kamiya R, Witman GB. DC3, the 21-kDa subunit of the outer dynein arm-docking complex (ODA-DC), is a novel EF-hand protein important for assembly of both the outer arm and the ODA-DC. Molecular Biology of the Cell. 14: 3650-63. PMID 12972554 DOI: 10.1091/mbc.E03-01-0057  0.68
2003 Pazour GJ, Witman GB. The vertebrate primary cilium is a sensory organelle. Current Opinion in Cell Biology. 15: 105-10. PMID 12517711  0.68
2002 Rosenbaum JL, Witman GB. Intraflagellar transport. Nature Reviews. Molecular Cell Biology. 3: 813-25. PMID 12415299 DOI: 10.1038/nrm952  0.68
2002 Pazour GJ, San Agustin JT, Follit JA, Rosenbaum JL, Witman GB. Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Current Biology : Cb. 12: R378-80. PMID 12062067 DOI: 10.1016/S0960-9822(02)00877-1  0.68
2002 Pazour GJ, Baker SA, Deane JA, Cole DG, Dickert BL, Rosenbaum JL, Witman GB, Besharse JC. The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance. The Journal of Cell Biology. 157: 103-13. PMID 11916979 DOI: 10.1083/jcb.200107108  0.68
2000 Pazour GJ, Witman GB. Forward and reverse genetic analysis of microtubule motors in Chlamydomonas. Methods (San Diego, Calif.). 22: 285-98. PMID 11133235 DOI: 10.1006/meth.2000.1081  0.68
2000 Pazour GJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL, Witman GB, Cole DG. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. The Journal of Cell Biology. 151: 709-18. PMID 11062270 DOI: 10.1083/jcb.151.3.709  0.68
1999 Pazour GJ, Koutoulis A, Benashski SE, Dickert BL, Sheng H, Patel-King RS, King SM, Witman GB. LC2, the chlamydomonas homologue of the t complex-encoded protein Tctex2, is essential for outer dynein arm assembly. Molecular Biology of the Cell. 10: 3507-20. PMID 10512883  0.68
1999 Horst CJ, Fishkind DJ, Pazour GJ, Witman GB. An insertional mutant of Chlamydomonas reinhardtii with defective microtubule positioning Cell Motility and the Cytoskeleton. 44: 143-154. PMID 10506749 DOI: 10.1002/(SICI)1097-0169(199910)44:2<143::AID-CM6>3.0.CO;2-3  0.68
1999 Pazour GJ, Dickert BL, Witman GB. The DHC1b (DHC2) isoform of cytoplasmic dynein is required for flagellar assembly. The Journal of Cell Biology. 144: 473-81. PMID 9971742  0.68
1998 Pazour GJ, Wilkerson CG, Witman GB. A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT). The Journal of Cell Biology. 141: 979-92. PMID 9585416  0.68
1997 Koutoulis A, Pazour GJ, Wilkerson CG, Inaba K, Sheng H, Takada S, Witman GB. The Chlamydomonas reinhardtii ODA3 gene encodes a protein of the outer dynein arm docking complex. The Journal of Cell Biology. 137: 1069-80. PMID 9166407  0.68
1995 Wilkerson CG, King SM, Koutoulis A, Pazour GJ, Witman GB. The 78,000 M(r) intermediate chain of Chlamydomonas outer arm dynein isa WD-repeat protein required for arm assembly. The Journal of Cell Biology. 129: 169-78. PMID 7698982  0.68
1995 Pazour GJ, Sineshchekov OA, Witman GB. Mutational analysis of the phototransduction pathway of Chlamydomonas reinhardtii. The Journal of Cell Biology. 131: 427-40. PMID 7593169  0.68
1995 Moss AG, Pazour GJ, Witman GB. Assay of Chlamydomonas phototaxis. Methods in Cell Biology. 47: 281-7. PMID 7476500  0.68
1974 Dentler WL, Granett S, Witman GB, Rosenbaum JL. Directionality of brain microtubule assembly in vitro Proceedings of the National Academy of Sciences of the United States of America. 71: 1710-1714. PMID 4134974  0.68
1972 Witman GB, Carlson K, Rosenbaum JL. Chlamydomonas flagella. II. The distribution of tubulins 1 and 2 in the outer doublet microtubules Journal of Cell Biology. 54: 540-555. PMID 5044758  0.68
1972 Witman GB, Carlson K, Berliner J, Rosenbaum JL. Chlamydomonas flagella. I. Isolation and electrophoretic analysis of microtubules, matrix, membranes, and mastigonemes Journal of Cell Biology. 54: 507-539. PMID 4558009  0.68
1971 Olmsted JB, Witman GB, Carlson K, Rosenbaum JL. Comparison of the microtubule proteins of neuroblastoma cells, brain, and Chlamydomonas flagella Proceedings of the National Academy of Sciences of the United States of America. 68: 2273-2277. PMID 5289385  0.68
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