Rene Medema - Publications

Affiliations: 
2001-2005 Cell Biology Netherlands Cancer Institute 
 2005- Utrecht University, Utrecht, Netherlands 
Area:
oncology
Website:
http://www.umcutrecht.nl/nl/Ziekenhuis/Zorgverleners/Medema-RH.aspx

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Warmerdam DO, Alonso-de Vega I, Wiegant WW, van den Broek B, Rother MB, Wolthuis RM, Freire R, van Attikum H, Medema RH, Smits VA. PHF6 promotes non-homologous end joining and G2 checkpoint recovery. Embo Reports. e48460. PMID 31782600 DOI: 10.15252/embr.201948460  0.32
2019 Raaijmakers JA, Medema RH. Killing a zombie: a full deletion of the BUB1 gene in HAP1 cells. The Embo Journal. e102423. PMID 31642077 DOI: 10.15252/embj.2019102423  0.64
2019 Elbatsh AMO, Kim E, Eeftens JM, Raaijmakers JA, van der Weide RH, García-Nieto A, Bravo S, Ganji M, Uit de Bos J, Teunissen H, Medema RH, de Wit E, Haering CH, Dekker C, Rowland BD. Distinct Roles for Condensin's Two ATPase Sites in Chromosome Condensation. Molecular Cell. PMID 31629658 DOI: 10.1016/j.molcel.2019.09.020  0.64
2019 Krenning L, van den Berg J, Medema RH. Life or Death after a Break: What Determines the Choice? Molecular Cell. PMID 31561953 DOI: 10.1016/j.molcel.2019.08.023  1
2019 Soto M, Raaijmakers JA, Medema RH. Consequences of Genomic Diversification Induced by Segregation Errors. Trends in Genetics : Tig. PMID 30745166 DOI: 10.1016/j.tig.2019.01.003  0.64
2018 Hansen MJ, Feringa FM, Kobauri P, Szymanski W, Medema RH, Feringa BL. Photoactivation of MDM2 Inhibitors: Controlling Protein-Protein Interaction with Light. Journal of the American Chemical Society. PMID 30284823 DOI: 10.1021/jacs.8b04870  0.64
2018 van den Berg J, G Manjón A, Kielbassa K, Feringa FM, Freire R, Medema RH. A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression. Nucleic Acids Research. PMID 30184135 DOI: 10.1093/nar/gky786  0.64
2018 Janssen LME, Averink TV, Blomen VA, Brummelkamp TR, Medema RH, Raaijmakers JA. Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores. Current Biology : Cb. PMID 30122526 DOI: 10.1016/j.cub.2018.06.026  0.64
2018 Soto M, García-Santisteban I, Krenning L, Medema RH, Raaijmakers JA. Chromosomes trapped in micronuclei are liable to segregation errors. Journal of Cell Science. PMID 29930083 DOI: 10.1242/jcs.214742  1
2018 Eifler K, Cuijpers SAG, Willemstein E, Raaijmakers JA, El Atmioui D, Ovaa H, Medema RH, Vertegaal ACO. SUMO targets the APC/C to regulate transition from metaphase to anaphase. Nature Communications. 9: 1119. PMID 29549242 DOI: 10.1038/s41467-018-03486-4  0.64
2018 Halim VA, García-Santisteban I, Warmerdam DO, van den Broek B, Heck AJR, Mohammed S, Medema RH. Doxorubicin-induced DNA damage causes extensive ubiquitination of ribosomal proteins associated with a decrease in protein translation. Molecular & Cellular Proteomics : McP. PMID 29438997 DOI: 10.1074/mcp.RA118.000652  0.4
2018 Raaijmakers JA, van Heesbeen RGHP, Blomen VA, Janssen LME, van Diemen F, Brummelkamp TR, Medema RH. BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised. Cell Reports. 22: 1424-1438. PMID 29425499 DOI: 10.1016/j.celrep.2018.01.034  0.64
2017 Tame MA, Manjón AG, Belokhvostova D, Raaijmakers JA, Medema RH. TUBB3 overexpression has a negligible effect on the sensitivity to taxol in cultured cell lines. Oncotarget. 8: 71536-71547. PMID 29069726 DOI: 10.18632/oncotarget.17740  0.64
2017 van der Vaart B, Fischböck J, Mieck C, Pichler P, Mechtler K, Medema RH, Westermann S. TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2. The Journal of Cell Biology. PMID 28972103 DOI: 10.1083/jcb.201606080  0.44
2017 Hiruma Y, Koch A, Hazraty N, Tsakou F, Medema RH, Joosten RP, Perrakis A. Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures. The Journal of Biological Chemistry. PMID 28726638 DOI: 10.1074/jbc.M117.783555  0.32
2017 Soto M, Raaijmakers JA, Bakker B, Spierings DCJ, Lansdorp PM, Foijer F, Medema RH. p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies. Cell Reports. 19: 2423-2431. PMID 28636931 DOI: 10.1016/j.celrep.2017.05.055  0.64
2017 Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, Helleday T, Medema RH, Macurek L, Lindqvist A. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. The Embo Journal. PMID 28607002 DOI: 10.15252/embj.201696082  0.44
2017 Tame MA, Manjón AG, Belokhvostova D, Raaijmakers JA, Medema RH. TUBB3 overexpression has a negligible effect on the sensitivity to taxol in cultured cell lines. Oncotarget. PMID 28548923 DOI: 10.18632/oncotarget.17740  0.64
2017 Sansregret L, Patterson JO, Dewhurst S, López-García C, Koch A, McGranahan N, Chao WC, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, et al. APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. Cancer Discovery. PMID 28069571 DOI: 10.1158/2159-8290.CD-16-0645  0.32
2016 Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJ, de Rink I, Medema RH, Giepmans BN, Perrakis A, Jalink K, Versteeg R, Moolenaar WH. Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome. Cancer Cell. 30: 986. PMID 27960089 DOI: 10.1016/j.ccell.2016.11.008  0.64
2016 Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJ, de Rink I, Medema RH, Giepmans BN, Perrakis A, Jalink K, Versteeg R, Moolenaar WH. Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome. Cancer Cell. PMID 27693046 DOI: 10.1016/j.ccell.2016.08.016  0.64
2016 Omta WA, van Heesbeen RG, Pagliero RJ, van der Velden LM, Lelieveld D, Nellen M, Kramer M, Yeong M, Saeidi AM, Medema RH, Spruit M, Brinkkemper S, Klumperman J, Egan DA. HC StratoMineR: A Web-Based Tool for the Rapid Analysis of High-Content Datasets. Assay and Drug Development Technologies. 14: 439-452. PMID 27636821 DOI: 10.1089/adt.2016.726  0.76
2016 Feringa FM, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, Medema RH. Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. Nature Communications. 7: 12618. PMID 27561326 DOI: 10.1038/ncomms12618  1
2016 van Heesbeen RG, Raaijmakers JA, Tanenbaum ME, Halim VA, Lelieveld D, Lieftink C, Heck AJ, Egan DA, Medema RH. Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation. Chromosoma. PMID 27354041 DOI: 10.1007/s00412-016-0607-4  0.6
2016 Vecchione L, Gambino V, Raaijmakers J, Schlicker A, Fumagalli A, Russo M, Villanueva A, Beerling E, Bartolini A, Mollevi DG, El-Murr N, Chiron M, Calvet L, Nicolazzi C, Combeau C, ... ... Medema RH, et al. A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility. Cell. 165: 317-30. PMID 27058664 DOI: 10.1016/j.cell.2016.02.059  0.6
2016 Warmerdam DO, van den Berg J, Medema RH. Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats. Cell Reports. 14: 2519-27. PMID 26972008 DOI: 10.1016/j.celrep.2016.02.048  0.64
2016 Bruinsma W, van den Berg J, Aprelia M, Medema RH. Tousled-like kinase 2 regulates recovery from a DNA damage-induced G2 arrest. Embo Reports. 17: 659-70. PMID 26931568 DOI: 10.15252/embr.201540767  0.64
2016 Elbatsh AM, Haarhuis JH, Petela N, Chapard C, Fish A, Celie PH, Stadnik M, Ristic D, Wyman C, Medema RH, Nasmyth K, Rowland BD. Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening. Molecular Cell. 61: 575-88. PMID 26895426 DOI: 10.1016/j.molcel.2016.01.025  0.6
2016 Tame MA, Raaijmakers JA, Afanasyev P, Medema RH. Chromosome misalignments induce spindle-positioning defects. Embo Reports. 17: 317-25. PMID 26882550 DOI: 10.15252/embr.201541143  0.6
2015 Bruinsma W, Aprelia M, Kool J, Macurek L, Lindqvist A, Medema RH. Spatial Separation of Plk1 Phosphorylation and Activity. Frontiers in Oncology. 5: 132. PMID 26114094 DOI: 10.3389/fonc.2015.00132  0.6
2015 Maia AF, Tanenbaum ME, Galli M, Lelieveld D, Egan DA, Gassmann R, Sunkel CE, van den Heuvel S, Medema RH. Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1. Scientific Data. 2: 150020. PMID 25984351 DOI: 10.1038/sdata.2015.20  0.6
2015 Shaltiel IA, Krenning L, Bruinsma W, Medema RH. The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle. Journal of Cell Science. 128: 607-20. PMID 25609713 DOI: 10.1242/jcs.163766  1
2014 Krenning L, Medema RH. Enter the nucleus to exit the cycle. Cell Cycle (Georgetown, Tex.). 13: 2651-2. PMID 25486348 DOI: 10.4161/15384101.2014.948783  1
2014 Kim J, D'Annibale S, Magliozzi R, Low TY, Jansen P, Shaltiel IA, Mohammed S, Heck AJ, Medema RH, Guardavaccaro D. USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response. Molecular and Cellular Biology. 34: 4177-85. PMID 25202122 DOI: 10.1128/MCB.00530-14  0.6
2014 van Heesbeen RG, Tanenbaum ME, Medema RH. Balanced activity of three mitotic motors is required for bipolar spindle assembly and chromosome segregation. Cell Reports. 8: 948-56. PMID 25127142 DOI: 10.1016/j.celrep.2014.07.015  0.96
2014 Maia AR, van Heesbeen RG, Medema RH. A growing role for Aurora A in chromosome instability. Nature Cell Biology. 16: 739-41. PMID 25082197 DOI: 10.1038/ncb3018  0.76
2014 Elbatsh AMO, Medema RH, Rowland BD. Genomic stability: Boosting cohesion corrects CIN Current Biology. 24. PMID 24937285 DOI: 10.1016/j.cub.2014.05.009  0.6
2014 Krenning L, Feringa FM, Shaltiel IA, van den Berg J, Medema RH. Transient activation of p53 in G2 phase is sufficient to induce senescence. Molecular Cell. 55: 59-72. PMID 24910099 DOI: 10.1016/j.molcel.2014.05.007  1
2014 Shaltiel IA, Aprelia M, Saurin AT, Chowdhury D, Kops GJPL, Voest EE, Medema RH. Distinct phosphatases antagonize the p53 response in different phases of the cell cycle Proceedings of the National Academy of Sciences of the United States of America. 111: 7313-7318. PMID 24711418 DOI: 10.1073/pnas.1322021111  0.6
2014 Schimmel J, Eifler K, Sigurðsson JO, Cuijpers SA, Hendriks IA, Verlaan-de Vries M, Kelstrup CD, Francavilla C, Medema RH, Olsen JV, Vertegaal AC. Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein. Molecular Cell. 53: 1053-66. PMID 24582501 DOI: 10.1016/j.molcel.2014.02.001  0.6
2014 Akopyan K, Silva Cascales H, Hukasova E, Saurin AT, Müllers E, Jaiswal H, Hollman DA, Kops GJ, Medema RH, Lindqvist A. Assessing kinetics from fixed cells reveals activation of the mitotic entry network at the S/G2 transition. Molecular Cell. 53: 843-53. PMID 24582498 DOI: 10.1016/j.molcel.2014.01.031  0.6
2014 Tame MA, Raaijmakers JA, van den Broek B, Lindqvist A, Jalink K, Medema RH. Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning. Cell Cycle (Georgetown, Tex.). 13: 1162-70. PMID 24553118 DOI: 10.4161/cc.28031  0.6
2014 Bruinsma W, Macurek L, Freire R, Lindqvist A, Medema RH. Bora and Aurora-A continue to activate Plk1 in mitosis. Journal of Cell Science. 127: 801-11. PMID 24338364 DOI: 10.1242/jcs.137216  0.6
2013 Haarhuis JH, Elbatsh AM, van den Broek B, Camps D, Erkan H, Jalink K, Medema RH, Rowland BD. WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy. Current Biology : Cb. 23: 2071-7. PMID 24055153 DOI: 10.1016/j.cub.2013.09.003  0.6
2013 van Heesbeen RG, Raaijmakers JA, Tanenbaum ME, Medema RH. Nuclear envelope-associated dynein cooperates with Eg5 to drive prophase centrosome separation. Communicative & Integrative Biology. 6: e23841. PMID 23713137 DOI: 10.4161/cib.23841  0.96
2013 Janssen A, Beerling E, Medema R, van Rheenen J. Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy. Plos One. 8: e64029. PMID 23691140 DOI: 10.1371/journal.pone.0064029  0.92
2013 Kleiblova P, Shaltiel IA, Benada J, Ševčík J, Pecháčková S, Pohlreich P, Voest EE, Dundr P, Bartek J, Kleibl Z, Medema RH, Macurek L. Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. The Journal of Cell Biology. 201: 511-21. PMID 23649806 DOI: 10.1083/jcb.201210031  0.64
2013 Halim VA, Alvarez-Fernández M, Xu YJ, Aprelia M, van den Toorn HW, Heck AJ, Mohammed S, Medema RH. Comparative phosphoproteomic analysis of checkpoint recovery identifies new regulators of the DNA damage response. Science Signaling. 6: rs9. PMID 23612710 DOI: 10.1126/scisignal.2003664  0.6
2013 Basten SG, Davis EE, Gillis AJ, van Rooijen E, Stoop H, Babala N, Logister I, Heath ZG, Jonges TN, Katsanis N, Voest EE, van Eeden FJ, Medema RH, Ketting RF, Schulte-Merker S, et al. Mutations in LRRC50 predispose zebrafish and humans to seminomas. Plos Genetics. 9: e1003384. PMID 23599692 DOI: 10.1371/journal.pgen.1003384  0.6
2013 Raaijmakers JA, Tanenbaum ME, Medema RH. Systematic dissection of dynein regulators in mitosis. The Journal of Cell Biology. 201: 201-15. PMID 23589491 DOI: 10.1083/jcb.201208098  0.96
2013 Alvarez-Fernández M, Medema RH. Novel functions of FoxM1: from molecular mechanisms to cancer therapy. Frontiers in Oncology. 3: 30. PMID 23467617 DOI: 10.3389/fonc.2013.00030  0.6
2013 Warmerdam DO, Brinkman EK, Marteijn JA, Medema RH, Kanaar R, Smits VA. UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway. Journal of Cell Science. 126: 1923-30. PMID 23447674 DOI: 10.1242/jcs.118265  0.6
2013 Janssen A, Medema RH. Cancer: Stress mixes chromosomes. Nature. 494: 439-41. PMID 23446415 DOI: 10.1038/494439a  0.92
2013 Macurek L, Benada J, Müllers E, Halim VA, Krejčíková K, Burdová K, Pecháčková S, Hodný Z, Lindqvist A, Medema RH, Bartek J. Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis. Cell Cycle (Georgetown, Tex.). 12: 251-62. PMID 23255129 DOI: 10.4161/cc.23057  0.44
2012 Bruinsma W, Raaijmakers JA, Medema RH. Switching Polo-like kinase-1 on and off in time and space. Trends in Biochemical Sciences. 37: 534-42. PMID 23141205 DOI: 10.1016/j.tibs.2012.09.005  0.64
2012 Raaijmakers JA, van Heesbeen RG, Meaders JL, Geers EF, Fernandez-Garcia B, Medema RH, Tanenbaum ME. Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation. The Embo Journal. 31: 4179-90. PMID 23034402 DOI: 10.1038/emboj.2012.272  0.96
2012 Höpker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger-Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, ... ... Medema RH, et al. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. The Embo Journal. 31: 3961-75. PMID 22909821 DOI: 10.1038/emboj.2012.236  0.6
2012 van der Waal MS, Saurin AT, Vromans MJ, Vleugel M, Wurzenberger C, Gerlich DW, Medema RH, Kops GJ, Lens SM. Mps1 promotes rapid centromere accumulation of Aurora B. Embo Reports. 13: 847-54. PMID 22732840 DOI: 10.1038/embor.2012.93  0.6
2012 Fairley JA, Mitchell LE, Berg T, Kenneth NS, von Schubert C, Silljé HH, Medema RH, Nigg EA, White RJ. Direct regulation of tRNA and 5S rRNA gene transcription by Polo-like kinase 1. Molecular Cell. 45: 541-52. PMID 22281053 DOI: 10.1016/j.molcel.2011.11.030  0.6
2011 Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, et al. FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell. 20: 427-42. PMID 22014570 DOI: 10.1016/j.ccr.2011.08.016  0.6
2011 Janssen A, van der Burg M, Szuhai K, Kops GJ, Medema RH. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science (New York, N.Y.). 333: 1895-8. PMID 21960636 DOI: 10.1126/science.1210214  0.92
2011 Roodhart JM, Daenen LG, Stigter EC, Prins HJ, Gerrits J, Houthuijzen JM, Gerritsen MG, Schipper HS, Backer MJ, van Amersfoort M, Vermaat JS, Moerer P, Ishihara K, Kalkhoven E, Beijnen JH, ... ... Medema RH, et al. Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Cancer Cell. 20: 370-83. PMID 21907927 DOI: 10.1016/j.ccr.2011.08.010  0.6
2011 Tanenbaum ME, Medema RH, Akhmanova A. Regulation of localization and activity of the microtubule depolymerase MCAK. Bioarchitecture. 1: 80-87. PMID 21866268 DOI: 10.4161/bioa.1.2.15807  0.96
2011 Domínguez-Kelly R, Martín Y, Koundrioukoff S, Tanenbaum ME, Smits VA, Medema RH, Debatisse M, Freire R. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. The Journal of Cell Biology. 194: 567-79. PMID 21859861 DOI: 10.1083/jcb.201101047  0.96
2011 Tanenbaum ME, Macurek L, van der Vaart B, Galli M, Akhmanova A, Medema RH. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Current Biology : Cb. 21: 1356-65. PMID 21820309 DOI: 10.1016/j.cub.2011.07.017  0.96
2011 Alvarez-Fernández M, Halim VA, Aprelia M, Laoukili J, Mohammed S, Medema RH. Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation. The Journal of Biological Chemistry. 286: 33029-36. PMID 21813648 DOI: 10.1074/jbc.M111.253724  0.6
2011 Tanenbaum ME, Medema RH. Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly. Chromosoma. 120: 599-607. PMID 21786106 DOI: 10.1007/s00412-011-0334-9  0.96
2011 Medema RH, Macurek L. Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer. F1000 Biology Reports. 3: 10. PMID 21655336 DOI: 10.3410/B3-10  0.44
2011 Saurin AT, van der Waal MS, Medema RH, Lens SM, Kops GJ. Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nature Communications. 2: 316. PMID 21587233 DOI: 10.1038/ncomms1319  0.6
2011 Tanenbaum ME, Akhmanova A, Medema RH. Bi-directional transport of the nucleus by dynein and kinesin-1. Communicative & Integrative Biology. 4: 21-5. PMID 21509171 DOI: 10.4161/cib.4.1.13780  0.96
2011 Janssen A, Kops GJ, Medema RH. Targeting the mitotic checkpoint to kill tumor cells. Hormones & Cancer. 2: 113-6. PMID 21475725 DOI: 10.1007/s12672-010-0059-x  0.92
2011 Janssen A, Medema RH. Entosis: aneuploidy by invasion. Nature Cell Biology. 13: 199-201. PMID 21364569 DOI: 10.1038/ncb0311-199  0.92
2010 Alvarez-Fernández M, Medema RH, Lindqvist A. Transcriptional regulation underlying recovery from a DNA damage-induced arrest. Transcription. 1: 32-5. PMID 21327155 DOI: 10.4161/trns.1.1.12063  0.6
2010 Tanenbaum ME, Medema RH. Mechanisms of centrosome separation and bipolar spindle assembly. Developmental Cell. 19: 797-806. PMID 21145497 DOI: 10.1016/j.devcel.2010.11.011  0.96
2010 Tanenbaum ME, Akhmanova A, Medema RH. Dynein at the nuclear envelope. Embo Reports. 11: 649. PMID 20805838 DOI: 10.1038/embor.2010.127  0.96
2010 Alvarez-Fernández M, Medema RH. A new role for Cdks in the DNA damage response. Cell Cycle (Georgetown, Tex.). 9: 2915-6. PMID 20714217 DOI: 10.4161/cc.9.15.12700  0.6
2010 Splinter D, Tanenbaum ME, Lindqvist A, Jaarsma D, Flotho A, Yu KL, Grigoriev I, Engelsma D, Haasdijk ED, Keijzer N, Demmers J, Fornerod M, Melchior F, Hoogenraad CC, Medema RH, et al. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry Plos Biology. 8. PMID 20386726 DOI: 10.1371/journal.pbio.1000350  0.6
2010 Alvarez-Fernández M, Halim VA, Krenning L, Aprelia M, Mohammed S, Heck AJ, Medema RH. Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1. Embo Reports. 11: 452-8. PMID 20379221 DOI: 10.1038/embor.2010.46  1
2010 Tanenbaum ME, Vallenius T, Geers EF, Greene L, Mäkelä TP, Medema RH. Cyclin G-associated kinase promotes microtubule outgrowth from chromosomes during spindle assembly. Chromosoma. 119: 415-24. PMID 20237935 DOI: 10.1007/s00412-010-0267-8  0.96
2010 Langenberg MH, Nijkamp MW, Roodhart JM, Snoeren N, Tang T, Shaked Y, van Hillegersberg R, Witteveen PO, Vermaat JS, Kranenburg O, Kerbel RS, Medema RH, Borel Rinkes IH, Voest EE. Liver surgery induces an immediate mobilization of progenitor cells in liver cancer patients: A potential role for G-CSF. Cancer Biology & Therapy. 9: 743-8. PMID 20215863 DOI: 10.4161/cbt.9.9.11551  0.6
2009 Janssen A, Kops GJ, Medema RH. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 19108-13. PMID 19855003 DOI: 10.1073/pnas.0904343106  0.92
2009 Tanenbaum ME, Macůrek L, Janssen A, Geers EF, Alvarez-Fernández M, Medema RH. Kif15 cooperates with eg5 to promote bipolar spindle assembly. Current Biology : Cb. 19: 1703-11. PMID 19818618 DOI: 10.1016/j.cub.2009.08.027  0.96
2009 Rieder CL, Medema RH. No way out for tumor cells. Cancer Cell. 16: 274-5. PMID 19800571 DOI: 10.1016/j.ccr.2009.09.021  0.6
2009 Lindqvist A, de Bruijn M, Macurek L, Brás A, Mensinga A, Bruinsma W, Voets O, Kranenburg O, Medema RH. Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. The Embo Journal. 28: 3196-206. PMID 19713933 DOI: 10.1038/emboj.2009.246  0.6
2009 Raaijmakers JA, Tanenbaum ME, Maia AF, Medema RH. RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment. Journal of Cell Science. 122: 2436-45. PMID 19549680 DOI: 10.1242/jcs.051912  0.96
2009 Macurek L, Lindqvist A, Medema RH. Aurora-A and hBora join the game of Polo. Cancer Research. 69: 4555-8. PMID 19487276 DOI: 10.1158/0008-5472.CAN-09-0142  0.44
2009 van Leuken R, Clijsters L, van Zon W, Lim D, Yao XB, Wolthuis RMF, Yaffe MB, Medema RH, van Vugt MATM. Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1 Plos One. 4. PMID 19390576 DOI: 10.1371/journal.pone.0005282  0.6
2009 van Veelen W, Klompmaker R, Gloerich M, van Gasteren CJ, Kalkhoven E, Berger R, Lips CJ, Medema RH, Höppener JW, Acton DS. P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development. International Journal of Cancer. Journal International Du Cancer. 124: 339-45. PMID 18942719 DOI: 10.1002/ijc.23977  0.6
2008 Tanenbaum ME, Macůrek L, Galjart N, Medema RH. Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. The Embo Journal. 27: 3235-45. PMID 19020519 DOI: 10.1038/emboj.2008.242  0.96
2008 van Leuken RJ, Luna-Vargas MP, Sixma TK, Wolthuis RM, Medema RH. Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B. Cell Cycle (Georgetown, Tex.). 7: 2710-9. PMID 18728397  0.6
2008 Mac?rek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery Nature. 455: 119-123. PMID 18615013 DOI: 10.1038/nature07185  0.6
2008 Jelluma N, Brenkman AB, McLeod I, Yates JR, Cleveland DW, Medema RH, Kops GJ. Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. Plos One. 3: e2415. PMID 18545697 DOI: 10.1371/journal.pone.0002415  0.6
2008 van de Weerdt BC, Littler DR, Klompmaker R, Huseinovic A, Fish A, Perrakis A, Medema RH. Polo-box domains confer target specificity to the Polo-like kinase family. Biochimica Et Biophysica Acta. 1783: 1015-22. PMID 18359294 DOI: 10.1016/j.bbamcr.2008.02.019  0.6
2008 Laoukili J, Alvarez M, Meijer LA, Stahl M, Mohammed S, Kleij L, Heck AJ, Medema RH. Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain. Molecular and Cellular Biology. 28: 3076-87. PMID 18285455 DOI: 10.1128/MCB.01710-07  0.32
2008 Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 132: 233-46. PMID 18243099 DOI: 10.1016/j.cell.2007.11.046  0.6
2007 Tanenbaum ME, Medema RH. Cell fate in the Hand of Plk4. Nature Cell Biology. 9: 1127-9. PMID 17909526 DOI: 10.1038/ncb1007-1127  0.96
2007 Schüller U, Zhao Q, Godinho SA, Heine VM, Medema RH, Pellman D, Rowitch DH. Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors. Molecular and Cellular Biology. 27: 8259-70. PMID 17893320 DOI: 10.1128/MCB.00707-07  0.6
2007 Wheatley SP, Barrett RM, Andrews PD, Medema RH, Morley SJ, Swedlow JR, Lens SM. Phosphorylation by aurora-B negatively regulates survivin function during mitosis. Cell Cycle (Georgetown, Tex.). 6: 1220-30. PMID 17457057  0.6
2006 Tanenbaum ME, Galjart N, van Vugt MA, Medema RH. CLIP-170 facilitates the formation of kinetochore-microtubule attachments. The Embo Journal. 25: 45-57. PMID 16362039 DOI: 10.1038/sj.emboj.7600916  0.96
2005 Akhmanova A, Mausset-Bonnefont AL, van Cappellen W, Keijzer N, Hoogenraad CC, Stepanova T, Drabek K, van der Wees J, Mommaas M, Onderwater J, van der Meulen H, Tanenbaum ME, Medema RH, Hoogerbrugge J, Vreeburg J, et al. The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Genes & Development. 19: 2501-15. PMID 16230537 DOI: 10.1101/gad.344505  0.6
2005 van de Weerdt BC, van Vugt MA, Lindon C, Kauw JJ, Rozendaal MJ, Klompmaker R, Wolthuis RM, Medema RH. Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1. Molecular and Cellular Biology. 25: 2031-44. PMID 15713655 DOI: 10.1128/MCB.25.5.2031-2044.2005  0.6
2005 Kuiperij HB, van der Horst A, Raaijmakers J, Weijzen S, Medema RH, Bos JL, Burgering BM, Zwartkruis FJ. Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP. Oncogene. 24: 2087-95. PMID 15688004 DOI: 10.1038/sj.onc.1208450  0.6
2002 Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature. 419: 316-21. PMID 12239572 DOI: 10.1038/nature01036  0.6
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