Rene Medema - Publications

Affiliations: 
2001-2005 Cell Biology Netherlands Cancer Institute 
 2005- Utrecht University, Utrecht, Netherlands 
Area:
oncology
Website:
http://www.umcutrecht.nl/nl/Ziekenhuis/Zorgverleners/Medema-RH.aspx

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Laine A, Nagelli SG, Farrington C, Butt U, Cvrljevic AN, Vainonen JP, Feringa FM, Grönroos TJ, Gautam P, Khan S, Sihto H, Qiao X, Pavic K, Connolly DC, Kronqvist P, ... ... Medema RH, et al. CIP2A interacts with TopBP1 and drives basal-like breast cancer tumorigenesis. Cancer Research. PMID 34145035 DOI: 10.1158/0008-5472.CAN-20-3651  0.333
2021 Storchova R, Burdova K, Palek M, Medema RH, Macurek L. A novel assay for screening WIP1 phosphatase substrates in nuclear extracts. The Febs Journal. PMID 33982878 DOI: 10.1111/febs.15965  0.3
2021 Schep R, Brinkman EK, Leemans C, Vergara X, van der Weide RH, Morris B, van Schaik T, Manzo SG, Peric-Hupkes D, van den Berg J, Beijersbergen RL, Medema RH, van Steensel B. Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance. Molecular Cell. 81: 2216-2230.e10. PMID 33848455 DOI: 10.1016/j.molcel.2021.03.032  0.304
2021 Shaltiel IA, Llopis A, Aprelia M, Klompmaker R, Menegakis A, Krenning L, Medema RH. Combined Inactivation of Pocket Proteins and APC/C by Cdk4/6 Controls Recovery from DNA Damage in G1 Phase. Cells. 10. PMID 33806417 DOI: 10.3390/cells10030550  0.821
2021 Menegakis A, Klompmaker R, Vennin C, Arbusà A, Damen M, van den Broek B, Zips D, van Rheenen J, Krenning L, Medema RH. Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence. Cells. 10. PMID 33801903 DOI: 10.3390/cells10030610  0.786
2021 Will Castro LSEP, Pieters W, Alemdehy MF, Aslam MA, Buoninfante OA, Raaijmakers JA, Pilzecker B, van den Berk PCM, Te Riele H, Medema RH, Pedrosa RC, Jacobs H. The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity. Frontiers in Pharmacology. 12: 596535. PMID 33679394 DOI: 10.3389/fphar.2021.596535  0.361
2021 García-Santisteban I, Llopis A, Krenning L, Vallejo-Rodríguez J, van den Broek B, Zubiaga AM, Medema RH. Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells. Bmc Biology. 19: 35. PMID 33607997 DOI: 10.1186/s12915-021-00965-x  0.822
2021 Hornsveld M, Feringa FM, Krenning L, van den Berg J, Smits LMM, Nguyen NBT, Rodríguez-Colman MJ, Dansen TB, Medema RH, Burgering BMT. A FOXO-dependent replication checkpoint restricts proliferation of damaged cells. Cell Reports. 34: 108675. PMID 33503422 DOI: 10.1016/j.celrep.2020.108675  0.809
2021 Krenning L, Raaijmakers JA, Medema RH. Centrosomes: Please keep your social distance! The Embo Journal. e107525. PMID 33491191 DOI: 10.15252/embj.2020107525  0.798
2020 Hoevenaar WHM, Janssen A, Quirindongo AI, Ma H, Klaasen SJ, Teixeira A, van Gerwen B, Lansu N, Morsink FHM, Offerhaus GJA, Medema RH, Kops GJPL, Jelluma N. Degree and site of chromosomal instability define its oncogenic potential. Nature Communications. 11: 1501. PMID 32198375 DOI: 10.1038/S41467-020-15279-9  0.558
2019 Warmerdam DO, Alonso-de Vega I, Wiegant WW, van den Broek B, Rother MB, Wolthuis RM, Freire R, van Attikum H, Medema RH, Smits VA. PHF6 promotes non-homologous end joining and G2 checkpoint recovery. Embo Reports. e48460. PMID 31782600 DOI: 10.15252/embr.201948460  0.337
2019 Krenning L, van den Berg J, Medema RH. Life or Death after a Break: What Determines the Choice? Molecular Cell. PMID 31561953 DOI: 10.1016/J.Molcel.2019.08.023  0.801
2018 Feringa FM, Raaijmakers JA, Hadders MA, Vaarting C, Macurek L, Heitink L, Krenning L, Medema RH. Persistent repair intermediates induce senescence. Nature Communications. 9: 3923. PMID 30254262 DOI: 10.1038/S41467-018-06308-9  0.822
2018 van den Berg J, G Manjón A, Kielbassa K, Feringa FM, Freire R, Medema RH. A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression. Nucleic Acids Research. PMID 30184135 DOI: 10.1093/nar/gky786  0.312
2018 Janssen LME, Averink TV, Blomen VA, Brummelkamp TR, Medema RH, Raaijmakers JA. Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores. Current Biology : Cb. PMID 30122526 DOI: 10.1016/j.cub.2018.06.026  0.323
2018 Macedo JC, Vaz S, Bakker B, Ribeiro R, Bakker PL, Escandell JM, Ferreira MG, Medema R, Foijer F, Logarinho E. FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence. Nature Communications. 9: 2834. PMID 30026603 DOI: 10.1038/S41467-018-05258-6  0.307
2018 Soto M, García-Santisteban I, Krenning L, Medema RH, Raaijmakers JA. Chromosomes trapped in micronuclei are liable to segregation errors. Journal of Cell Science. PMID 29930083 DOI: 10.1242/Jcs.214742  0.816
2018 Eifler K, Cuijpers SAG, Willemstein E, Raaijmakers JA, El Atmioui D, Ovaa H, Medema RH, Vertegaal ACO. SUMO targets the APC/C to regulate transition from metaphase to anaphase. Nature Communications. 9: 1119. PMID 29549242 DOI: 10.1038/S41467-018-03486-4  0.302
2018 Halim VA, García-Santisteban I, Warmerdam DO, van den Broek B, Heck AJR, Mohammed S, Medema RH. Doxorubicin-induced DNA damage causes extensive ubiquitination of ribosomal proteins associated with a decrease in protein translation. Molecular & Cellular Proteomics : McP. PMID 29438997 DOI: 10.1074/Mcp.Ra118.000652  0.315
2018 Raaijmakers JA, van Heesbeen RGHP, Blomen VA, Janssen LME, van Diemen F, Brummelkamp TR, Medema RH. BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised. Cell Reports. 22: 1424-1438. PMID 29425499 DOI: 10.1016/j.celrep.2018.01.034  0.361
2018 Menegakis A, Van den Broek B, Medema R. EP-2334: A method to assess radiation-induced DNA damage and microenvironmental parameters in tumor spheroids Radiotherapy and Oncology. 127: S1287-S1288. DOI: 10.1016/S0167-8140(18)32643-4  0.307
2017 van der Vaart B, Fischböck J, Mieck C, Pichler P, Mechtler K, Medema RH, Westermann S. TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2. The Journal of Cell Biology. PMID 28972103 DOI: 10.1083/jcb.201606080  0.366
2017 Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, Helleday T, Medema RH, Macurek L, Lindqvist A. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. The Embo Journal. PMID 28607002 DOI: 10.15252/embj.201696082  0.428
2017 Libouban MAA, de Roos JADM, Uitdehaag JCM, Willemsen-Seegers N, Mainardi S, Dylus J, de Man J, Tops B, Meijerink JPP, Storchová Z, Buijsman RC, Medema RH, Zaman GJR. Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines. Oncotarget. PMID 28415765 DOI: 10.18632/oncotarget.16213  0.322
2016 Bruinsma W, Aprelia M, García-Santisteban I, Kool J, Xu YJ, Medema RH. Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora. Oncogene. PMID 27721411 DOI: 10.1038/onc.2016.347  0.354
2016 Feringa FM, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, Medema RH. Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. Nature Communications. 7: 12618. PMID 27561326 DOI: 10.1038/Ncomms12618  0.829
2016 van Heesbeen RG, Raaijmakers JA, Tanenbaum ME, Halim VA, Lelieveld D, Lieftink C, Heck AJ, Egan DA, Medema RH. Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation. Chromosoma. PMID 27354041 DOI: 10.1007/S00412-016-0607-4  0.816
2016 Warmerdam DO, van den Berg J, Medema RH. Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats. Cell Reports. 14: 2519-27. PMID 26972008 DOI: 10.1016/j.celrep.2016.02.048  0.325
2016 Bruinsma W, van den Berg J, Aprelia M, Medema RH. Tousled-like kinase 2 regulates recovery from a DNA damage-induced G2 arrest. Embo Reports. 17: 659-70. PMID 26931568 DOI: 10.15252/embr.201540767  0.428
2015 Koch A, Maia A, Janssen A, Medema RH. Molecular basis underlying resistance to Mps1/TTK inhibitors. Oncogene. PMID 26364596 DOI: 10.1038/Onc.2015.319  0.56
2015 Maia AR, de Man J, Boon U, Janssen A, Song JY, Omerzu M, Sterrenburg JG, Prinsen MB, Willemsen-Seegers N, de Roos JA, van Doornmalen AM, Uitdehaag JC, Kops GJ, Jonkers J, Buijsman RC, ... ... Medema RH, et al. Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 26: 2180-92. PMID 26153498 DOI: 10.1093/Annonc/Mdv293  0.564
2015 Maia AF, Tanenbaum ME, Galli M, Lelieveld D, Egan DA, Gassmann R, Sunkel CE, van den Heuvel S, Medema RH. Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1. Scientific Data. 2: 150020. PMID 25984351 DOI: 10.1038/Sdata.2015.20  0.792
2015 Shaltiel IA, Krenning L, Bruinsma W, Medema RH. The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle. Journal of Cell Science. 128: 607-20. PMID 25609713 DOI: 10.1242/Jcs.163766  0.826
2015 Zaman G, de Man J, Uitdehaag J, Maia A, Boon U, Sterrenburg J, Prinsen M, Willemsen-Seegers N, Jonkers J, Kops G, Medema R, Buijsman R. Identification of selective inhibitors of the spindle assembly checkpoint kinase TTK (Mps1) for treatment of triple negative breast cancer Annals of Oncology. 26: ii28. DOI: 10.1093/Annonc/Mdv095.9  0.373
2014 Medema R, Maia AR, Janssen A, Koch A, Boon U, Buijsman RC, Zaman GJ, Jonkers J. 6INTHE INTERFACE BETWEEN CANCER NUMERICAL AND STRUCTURAL CHROMOSOMAL INSTABILITY: MECHANISMS ACCELERATING CANCER DIVERSITY. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 25: iv4. PMID 28170562 DOI: 10.1093/Annonc/Mdu290.3  0.668
2014 Krenning L, Medema RH. Enter the nucleus to exit the cycle. Cell Cycle (Georgetown, Tex.). 13: 2651-2. PMID 25486348 DOI: 10.4161/15384101.2014.948783  0.773
2014 Kim J, D'Annibale S, Magliozzi R, Low TY, Jansen P, Shaltiel IA, Mohammed S, Heck AJ, Medema RH, Guardavaccaro D. USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response. Molecular and Cellular Biology. 34: 4177-85. PMID 25202122 DOI: 10.1128/Mcb.00530-14  0.372
2014 van Heesbeen RG, Tanenbaum ME, Medema RH. Balanced activity of three mitotic motors is required for bipolar spindle assembly and chromosome segregation. Cell Reports. 8: 948-56. PMID 25127142 DOI: 10.1016/J.Celrep.2014.07.015  0.793
2014 Krenning L, Feringa FM, Shaltiel IA, van den Berg J, Medema RH. Transient activation of p53 in G2 phase is sufficient to induce senescence. Molecular Cell. 55: 59-72. PMID 24910099 DOI: 10.1016/J.Molcel.2014.05.007  0.816
2014 Raaijmakers JA, Medema RH. Function and regulation of dynein in mitotic chromosome segregation. Chromosoma. 123: 407-22. PMID 24871939 DOI: 10.1007/s00412-014-0468-7  0.333
2014 Shaltiel IA, Aprelia M, Saurin AT, Chowdhury D, Kops GJPL, Voest EE, Medema RH. Distinct phosphatases antagonize the p53 response in different phases of the cell cycle Proceedings of the National Academy of Sciences of the United States of America. 111: 7313-7318. PMID 24711418 DOI: 10.1073/pnas.1322021111  0.34
2014 Schimmel J, Eifler K, Sigurðsson JO, Cuijpers SA, Hendriks IA, Verlaan-de Vries M, Kelstrup CD, Francavilla C, Medema RH, Olsen JV, Vertegaal AC. Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein. Molecular Cell. 53: 1053-66. PMID 24582501 DOI: 10.1016/j.molcel.2014.02.001  0.367
2014 Akopyan K, Silva Cascales H, Hukasova E, Saurin AT, Müllers E, Jaiswal H, Hollman DA, Kops GJ, Medema RH, Lindqvist A. Assessing kinetics from fixed cells reveals activation of the mitotic entry network at the S/G2 transition. Molecular Cell. 53: 843-53. PMID 24582498 DOI: 10.1016/j.molcel.2014.01.031  0.367
2014 Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Medema RH, Hung MC, Huang S. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis. The Journal of Clinical Investigation. 124: 564-79. PMID 24382352 DOI: 10.1172/Jci71104  0.363
2014 Khongkow P, Karunarathna U, Khongkow M, Gong C, Gomes AR, Yagüe E, Monteiro LJ, Kongsema M, Zona S, Man EP, Tsang JW, Coombes RC, Wu KJ, Khoo US, Medema RH, et al. FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance. Oncogene. 33: 4144-55. PMID 24141789 DOI: 10.1038/onc.2013.457  0.348
2013 Haarhuis JH, Elbatsh AM, van den Broek B, Camps D, Erkan H, Jalink K, Medema RH, Rowland BD. WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy. Current Biology : Cb. 23: 2071-7. PMID 24055153 DOI: 10.1016/j.cub.2013.09.003  0.365
2013 van Heesbeen RG, Raaijmakers JA, Tanenbaum ME, Medema RH. Nuclear envelope-associated dynein cooperates with Eg5 to drive prophase centrosome separation. Communicative & Integrative Biology. 6: e23841. PMID 23713137 DOI: 10.4161/Cib.23841  0.815
2013 Janssen A, Beerling E, Medema R, van Rheenen J. Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy. Plos One. 8: e64029. PMID 23691140 DOI: 10.1371/Journal.Pone.0064029  0.627
2013 Halim VA, Alvarez-Fernández M, Xu YJ, Aprelia M, van den Toorn HW, Heck AJ, Mohammed S, Medema RH. Comparative phosphoproteomic analysis of checkpoint recovery identifies new regulators of the DNA damage response. Science Signaling. 6: rs9. PMID 23612710 DOI: 10.1126/Scisignal.2003664  0.418
2013 Raaijmakers JA, Tanenbaum ME, Medema RH. Systematic dissection of dynein regulators in mitosis. The Journal of Cell Biology. 201: 201-15. PMID 23589491 DOI: 10.1083/Jcb.201208098  0.8
2013 Warmerdam DO, Brinkman EK, Marteijn JA, Medema RH, Kanaar R, Smits VA. UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway. Journal of Cell Science. 126: 1923-30. PMID 23447674 DOI: 10.1242/jcs.118265  0.334
2013 Janssen A, Medema RH. Cancer: Stress mixes chromosomes. Nature. 494: 439-41. PMID 23446415 DOI: 10.1038/494439A  0.614
2013 Macurek L, Benada J, Müllers E, Halim VA, Krejčíková K, Burdová K, Pecháčková S, Hodný Z, Lindqvist A, Medema RH, Bartek J. Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis. Cell Cycle (Georgetown, Tex.). 12: 251-62. PMID 23255129 DOI: 10.4161/cc.23057  0.465
2013 Monteiro LJ, Khongkow P, Kongsema M, Morris JR, Man C, Weekes D, Koo CY, Gomes AR, Pinto PH, Varghese V, Kenny LM, Charles Coombes R, Freire R, Medema RH, Lam EW. The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment. Oncogene. 32: 4634-45. PMID 23108394 DOI: 10.1038/onc.2012.491  0.329
2012 Janssen A, Medema RH. Genetic instability: tipping the balance. Oncogene. 32: 4459-70. PMID 23246960 DOI: 10.1038/Onc.2012.576  0.583
2012 Raaijmakers JA, van Heesbeen RG, Meaders JL, Geers EF, Fernandez-Garcia B, Medema RH, Tanenbaum ME. Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation. The Embo Journal. 31: 4179-90. PMID 23034402 DOI: 10.1038/Emboj.2012.272  0.814
2012 Höpker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger-Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, ... ... Medema RH, et al. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. The Embo Journal. 31: 3961-75. PMID 22909821 DOI: 10.1038/Emboj.2012.236  0.539
2011 Medema RH, Macůrek L. Checkpoint control and cancer. Oncogene. 31: 2601-13. PMID 21963855 DOI: 10.1038/onc.2011.451  0.349
2011 Janssen A, van der Burg M, Szuhai K, Kops GJ, Medema RH. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science (New York, N.Y.). 333: 1895-8. PMID 21960636 DOI: 10.1126/Science.1210214  0.632
2011 Tanenbaum ME, Medema RH, Akhmanova A. Regulation of localization and activity of the microtubule depolymerase MCAK. Bioarchitecture. 1: 80-87. PMID 21866268 DOI: 10.4161/bioa.1.2.15807  0.809
2011 Domínguez-Kelly R, Martín Y, Koundrioukoff S, Tanenbaum ME, Smits VA, Medema RH, Debatisse M, Freire R. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. The Journal of Cell Biology. 194: 567-79. PMID 21859861 DOI: 10.1083/Jcb.201101047  0.821
2011 Tanenbaum ME, Macurek L, van der Vaart B, Galli M, Akhmanova A, Medema RH. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Current Biology : Cb. 21: 1356-65. PMID 21820309 DOI: 10.1016/J.Cub.2011.07.017  0.806
2011 Alvarez-Fernández M, Halim VA, Aprelia M, Laoukili J, Mohammed S, Medema RH. Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation. The Journal of Biological Chemistry. 286: 33029-36. PMID 21813648 DOI: 10.1074/jbc.M111.253724  0.337
2011 Tanenbaum ME, Medema RH. Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly. Chromosoma. 120: 599-607. PMID 21786106 DOI: 10.1007/S00412-011-0334-9  0.791
2011 Medema RH, Macurek L. Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer. F1000 Biology Reports. 3: 10. PMID 21655336 DOI: 10.3410/B3-10  0.357
2011 Saurin AT, van der Waal MS, Medema RH, Lens SM, Kops GJ. Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nature Communications. 2: 316. PMID 21587233 DOI: 10.1038/ncomms1319  0.305
2011 Tanenbaum ME, Akhmanova A, Medema RH. Bi-directional transport of the nucleus by dynein and kinesin-1. Communicative & Integrative Biology. 4: 21-5. PMID 21509171 DOI: 10.4161/Cib.4.1.13780  0.804
2011 Janssen A, Kops GJ, Medema RH. Targeting the mitotic checkpoint to kill tumor cells. Hormones & Cancer. 2: 113-6. PMID 21475725 DOI: 10.1007/S12672-010-0059-X  0.633
2011 Janssen A, Medema RH. Entosis: aneuploidy by invasion. Nature Cell Biology. 13: 199-201. PMID 21364569 DOI: 10.1038/Ncb0311-199  0.613
2011 Janssen A, Medema RH. Mitosis as an anti-cancer target. Oncogene. 30: 2799-809. PMID 21339734 DOI: 10.1038/Onc.2011.30  0.607
2010 Alvarez-Fernández M, Medema RH, Lindqvist A. Transcriptional regulation underlying recovery from a DNA damage-induced arrest. Transcription. 1: 32-5. PMID 21327155 DOI: 10.4161/trns.1.1.12063  0.377
2010 Tanenbaum ME, Medema RH. Mechanisms of centrosome separation and bipolar spindle assembly. Developmental Cell. 19: 797-806. PMID 21145497 DOI: 10.1016/J.Devcel.2010.11.011  0.808
2010 Tanenbaum ME, Akhmanova A, Medema RH. Dynein at the nuclear envelope. Embo Reports. 11: 649. PMID 20805838 DOI: 10.1038/Embor.2010.127  0.799
2010 Splinter D, Tanenbaum ME, Lindqvist A, Jaarsma D, Flotho A, Yu KL, Grigoriev I, Engelsma D, Haasdijk ED, Keijzer N, Demmers J, Fornerod M, Melchior F, Hoogenraad CC, Medema RH, et al. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry Plos Biology. 8. PMID 20386726 DOI: 10.1371/Journal.Pbio.1000350  0.812
2010 Alvarez-Fernández M, Halim VA, Krenning L, Aprelia M, Mohammed S, Heck AJ, Medema RH. Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1. Embo Reports. 11: 452-8. PMID 20379221 DOI: 10.1038/Embor.2010.46  0.827
2010 Tanenbaum ME, Vallenius T, Geers EF, Greene L, Mäkelä TP, Medema RH. Cyclin G-associated kinase promotes microtubule outgrowth from chromosomes during spindle assembly. Chromosoma. 119: 415-24. PMID 20237935 DOI: 10.1007/S00412-010-0267-8  0.81
2010 Macůrek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH. Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition. Oncogene. 29: 2281-91. PMID 20101220 DOI: 10.1038/onc.2009.501  0.386
2009 De Marco V, Gillespie PJ, Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov MV, Iliou MS, Lygerou Z, Medema RH, Blow JJ, Svergun DI, Taraviras S, et al. Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing. Proceedings of the National Academy of Sciences of the United States of America. 106: 19807-12. PMID 19906994 DOI: 10.1073/Pnas.0905281106  0.326
2009 Janssen A, Kops GJ, Medema RH. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 19108-13. PMID 19855003 DOI: 10.1073/Pnas.0904343106  0.626
2009 Tanenbaum ME, Macůrek L, Janssen A, Geers EF, Alvarez-Fernández M, Medema RH. Kif15 cooperates with eg5 to promote bipolar spindle assembly. Current Biology : Cb. 19: 1703-11. PMID 19818618 DOI: 10.1016/J.Cub.2009.08.027  0.802
2009 Lindqvist A, de Bruijn M, Macurek L, Brás A, Mensinga A, Bruinsma W, Voets O, Kranenburg O, Medema RH. Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. The Embo Journal. 28: 3196-206. PMID 19713933 DOI: 10.1038/emboj.2009.246  0.429
2009 Raaijmakers JA, Tanenbaum ME, Maia AF, Medema RH. RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment. Journal of Cell Science. 122: 2436-45. PMID 19549680 DOI: 10.1242/Jcs.051912  0.805
2009 van Leuken R, Clijsters L, van Zon W, Lim D, Yao XB, Wolthuis RMF, Yaffe MB, Medema RH, van Vugt MATM. Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1 Plos One. 4. PMID 19390576 DOI: 10.1371/Journal.Pone.0005282  0.511
2008 Tanenbaum ME, Macůrek L, Galjart N, Medema RH. Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. The Embo Journal. 27: 3235-45. PMID 19020519 DOI: 10.1038/Emboj.2008.242  0.8
2008 Laoukili J, Alvarez-Fernandez M, Stahl M, Medema RH. FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner. Cell Cycle (Georgetown, Tex.). 7: 2720-6. PMID 18758239 DOI: 10.4161/cc.7.17.6580  0.308
2008 Mac?rek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery Nature. 455: 119-123. PMID 18615013 DOI: 10.1038/Nature07185  0.529
2008 Jelluma N, Brenkman AB, McLeod I, Yates JR, Cleveland DW, Medema RH, Kops GJ. Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. Plos One. 3: e2415. PMID 18545697 DOI: 10.1371/journal.pone.0002415  0.339
2008 Wolthuis R, Clay-Farrace L, van Zon W, Yekezare M, Koop L, Ogink J, Medema R, Pines J. Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Molecular Cell. 30: 290-302. PMID 18471975 DOI: 10.1016/J.Molcel.2008.02.027  0.462
2008 Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 132: 233-46. PMID 18243099 DOI: 10.1016/j.cell.2007.11.046  0.308
2007 Tanenbaum ME, Medema RH. Cell fate in the Hand of Plk4. Nature Cell Biology. 9: 1127-9. PMID 17909526 DOI: 10.1038/Ncb1007-1127  0.784
2007 Vader G, Cruijsen CW, van Harn T, Vromans MJ, Medema RH, Lens SM. The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions. Molecular Biology of the Cell. 18: 4553-64. PMID 17699588 DOI: 10.1091/mbc.E07-04-0328  0.385
2007 Laoukili J, Stahl M, Medema RH. FoxM1: at the crossroads of ageing and cancer. Biochimica Et Biophysica Acta. 1775: 92-102. PMID 17014965 DOI: 10.1016/j.bbcan.2006.08.006  0.309
2006 Freire R, van Vugt MA, Mamely I, Medema RH. Claspin: timing the cell cycle arrest when the genome is damaged. Cell Cycle (Georgetown, Tex.). 5: 2831-4. PMID 17172868 DOI: 10.4161/cc.5.24.3559  0.755
2006 Lens SM, Vader G, Medema RH. The case for Survivin as mitotic regulator. Current Opinion in Cell Biology. 18: 616-22. PMID 16962308 DOI: 10.1016/j.ceb.2006.08.016  0.335
2006 Mamely I, van Vugt MA, Smits VA, Semple JI, Lemmens B, Perrakis A, Medema RH, Freire R. Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Current Biology : Cb. 16: 1950-5. PMID 16934469 DOI: 10.1016/j.cub.2006.08.026  0.743
2006 Tanenbaum ME, Galjart N, van Vugt MA, Medema RH. CLIP-170 facilitates the formation of kinetochore-microtubule attachments. The Embo Journal. 25: 45-57. PMID 16362039 DOI: 10.1038/Sj.Emboj.7600916  0.802
2006 Schmidt M, Medema RH. Exploiting the compromised spindle assembly checkpoint function of tumor cells: dawn on the horizon? Cell Cycle (Georgetown, Tex.). 5: 159-63. PMID 16357537 DOI: 10.4161/cc.5.2.2309  0.358
2005 Foijer F, Wolthuis RM, Doodeman V, Medema RH, te Riele H. Mitogen requirement for cell cycle progression in the absence of pocket protein activity. Cancer Cell. 8: 455-66. PMID 16338659 DOI: 10.1016/j.ccr.2005.10.021  0.335
2005 Akhmanova A, Mausset-Bonnefont AL, van Cappellen W, Keijzer N, Hoogenraad CC, Stepanova T, Drabek K, van der Wees J, Mommaas M, Onderwater J, van der Meulen H, Tanenbaum ME, Medema RH, Hoogerbrugge J, Vreeburg J, et al. The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Genes & Development. 19: 2501-15. PMID 16230537 DOI: 10.1101/Gad.344505  0.767
2005 Schmidt M, Budirahardja Y, Klompmaker R, Medema RH. Ablation of the spindle assembly checkpoint by a compound targeting Mps1. Embo Reports. 6: 866-72. PMID 16113653 DOI: 10.1038/sj.embor.7400483  0.368
2005 van Vugt MA, Bràs A, Medema RH. Restarting the cell cycle when the checkpoint comes to a halt. Cancer Research. 65: 7037-40. PMID 16103048 DOI: 10.1158/0008-5472.CAN-05-1054  0.744
2005 van Vugt MA, Medema RH. Getting in and out of mitosis with Polo-like kinase-1. Oncogene. 24: 2844-59. PMID 15838519 DOI: 10.1038/sj.onc.1208617  0.744
2005 van de Weerdt BC, van Vugt MA, Lindon C, Kauw JJ, Rozendaal MJ, Klompmaker R, Wolthuis RM, Medema RH. Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1. Molecular and Cellular Biology. 25: 2031-44. PMID 15713655 DOI: 10.1128/MCB.25.5.2031-2044.2005  0.711
2005 Kuiperij HB, van der Horst A, Raaijmakers J, Weijzen S, Medema RH, Bos JL, Burgering BM, Zwartkruis FJ. Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP. Oncogene. 24: 2087-95. PMID 15688004 DOI: 10.1038/Sj.Onc.1208450  0.574
2005 Laoukili J, Kooistra MR, Brás A, Kauw J, Kerkhoven RM, Morrison A, Clevers H, Medema RH. FoxM1 is required for execution of the mitotic programme and chromosome stability. Nature Cell Biology. 7: 126-36. PMID 15654331 DOI: 10.1038/Ncb1217  0.369
2005 van Vugt MA, Medema RH. Polo-like kinase-1: activity measurement and RNAi-mediated knockdown. Methods in Molecular Biology (Clifton, N.J.). 296: 355-69. PMID 15576944  0.708
2004 van Vugt MA, Medema RH. Checkpoint adaptation and recovery: back with Polo after the break. Cell Cycle (Georgetown, Tex.). 3: 1383-6. PMID 15492511 DOI: 10.4161/cc.3.11.1248  0.743
2004 van Vugt MA, Brás A, Medema RH. Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Molecular Cell. 15: 799-811. PMID 15350223 DOI: 10.1016/J.MOLCEL.2004.07.015  0.758
2004 van Vugt MA, van de Weerdt BC, Vader G, Janssen H, Calafat J, Klompmaker R, Wolthuis RM, Medema RH. Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis. The Journal of Biological Chemistry. 279: 36841-54. PMID 15210710 DOI: 10.1074/JBC.M313681200  0.762
2004 Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G. Cell death by mitotic catastrophe: a molecular definition. Oncogene. 23: 2825-37. PMID 15077146 DOI: 10.1038/Sj.Onc.1207528  0.497
2004 Castedo M, Perfettini JL, Roumier T, Valent A, Raslova H, Yakushijin K, Horne D, Feunteun J, Lenoir G, Medema R, Vainchenker W, Kroemer G. Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy Oncogene. 23: 4362-4370. PMID 15048075 DOI: 10.1038/Sj.Onc.1207572  0.505
2004 Castedo M, Perfettini JL, Roumier T, Yakushijin K, Horne D, Medema R, Kroemer G. The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe Oncogene. 23: 4353-4361. PMID 15048074 DOI: 10.1038/Sj.Onc.1207573  0.514
2003 Lens SM, Wolthuis RM, Klompmaker R, Kauw J, Agami R, Brummelkamp T, Kops G, Medema RH. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. The Embo Journal. 22: 2934-47. PMID 12805209 DOI: 10.1093/emboj/cdg307  0.432
2002 van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, ... ... Medema R, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 111: 241-50. PMID 12408868 DOI: 10.1016/S0092-8674(02)01014-0  0.325
2002 Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature. 419: 316-21. PMID 12239572 DOI: 10.1038/Nature01036  0.537
2002 Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ, Lam EW, Burgering BM. Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Molecular and Cellular Biology. 22: 2025-36. PMID 11884591 DOI: 10.1128/Mcb.22.7.2025-2036.2002  0.362
2001 van Vugt MA, Smits VA, Klompmaker R, Medema RH. Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion. The Journal of Biological Chemistry. 276: 41656-60. PMID 11514540 DOI: 10.1074/JBC.M101831200  0.729
2001 Smits VA, Medema RH. Checking out the G(2)/M transition. Biochimica Et Biophysica Acta. 1519: 1-12. PMID 11406266 DOI: 10.1016/S0167-4781(01)00204-4  0.446
2001 Fajas L, Paul C, Vié A, Estrach S, Medema R, Blanchard JM, Sardet C, Vignais ML. Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1. Molecular and Cellular Biology. 21: 2956-66. PMID 11283272 DOI: 10.1128/Mcb.21.8.2956-2966.2001  0.447
2001 Smits VA, Klompmaker R, Arnaud L, Rijksen G, Nigg EA, Medema RH. Polo-like kinase-1 is a target of the DNA damage checkpoint. Nature Cell Biology. 2: 672-6. PMID 10980711 DOI: 10.1038/35023629  0.396
2000 Smits VA, Klompmaker R, Vallenius T, Rijksen G, Mäkela TP, Medema RH. p21 inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA damage checkpoint. The Journal of Biological Chemistry. 275: 30638-43. PMID 10913154 DOI: 10.1074/jbc.M005437200  0.352
2000 Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C. pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. Proceedings of the National Academy of Sciences of the United States of America. 97: 7738-43. PMID 10869426 DOI: 10.1073/Pnas.130198397  0.343
2000 Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature. 404: 782-7. PMID 10783894 DOI: 10.1038/35008115  0.575
2000 Smits VA, van Peer MA, Essers MA, Klompmaker R, Rijksen G, Medema RH. Negative growth regulation of SK-N-MC cells by bFGF defines a growth factor-sensitive point in G2. The Journal of Biological Chemistry. 275: 19375-81. PMID 10770932 DOI: 10.1074/JBC.M001764200  0.331
1999 Smits VA, Essers MA, Loomans DS, Klompmaker R, Rijksen G, Medema RH. Inhibition of cell proliferation by lithium is associated with interference in cdc2 activation. Febs Letters. 457: 23-7. PMID 10486556 DOI: 10.1016/S0014-5793(99)01002-9  0.371
1999 Geng Y, Whoriskey W, Park MY, Bronson RT, Medema RH, Li T, Weinberg RA, Sicinski P. Rescue of cyclin D1 deficiency by knockin cyclin E Cell. 97: 767-777. PMID 10380928 DOI: 10.1016/S0092-8674(00)80788-6  0.406
1999 Korver W, Schilham MW, Moerer P, van den Hoff MJ, Dam K, Lamers WH, Medema RH, Clevers H. Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident. Current Biology : Cb. 8: 1327-30. PMID 9843684 DOI: 10.1016/S0960-9822(07)00563-5  0.359
1998 van Oijen MG, Medema RH, Slootweg PJ, Rijksen G. Positivity of the proliferation marker Ki-67 in noncycling cells. American Journal of Clinical Pathology. 110: 24-31. PMID 9661919 DOI: 10.1093/AJCP/110.1.24  0.311
1998 Medema RH, Klompmaker R, Smits VA, Rijksen G. p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases. Oncogene. 16: 431-41. PMID 9484832 DOI: 10.1038/sj.onc.1201558  0.404
1995 Medema RH, Herrera RE, Lam F, Weinberg RA. Growth suppression by p16ink4 requires functional retinoblastoma protein. Proceedings of the National Academy of Sciences of the United States of America. 92: 6289-93. PMID 7603984 DOI: 10.1073/Pnas.92.14.6289  0.518
1994 Burgering BM, de Vries-Smits AM, Medema RH, van Weeren PC, Tertoolen LG, Bos JL. Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Molecular and Cellular Biology. 13: 7248-56. PMID 8246947 DOI: 10.1128/Mcb.13.12.7248  0.529
1994 Pronk GJ, de Vries-Smits AM, Buday L, Downward J, Maassen JA, Medema RH, Bos JL. Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras. Molecular and Cellular Biology. 14: 1575-81. PMID 8114695 DOI: 10.1128/Mcb.14.3.1575  0.591
1993 Osterop AP, Medema RH, vd Zon GC, Bos JL, Möller W, Maassen JA. Epidermal-growth-factor receptors generate Ras.GTP more efficiently than insulin receptors. European Journal of Biochemistry. 212: 477-82. PMID 8444185 DOI: 10.1111/J.1432-1033.1993.Tb17684.X  0.446
1993 Medema RH, de Vries-Smits AM, van der Zon GC, Maassen JA, Bos JL. Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras. Molecular and Cellular Biology. 13: 155-62. PMID 8417322 DOI: 10.1128/Mcb.13.1.155  0.47
1993 van Corven EJ, Hordijk PL, Medema RH, Bos JL, Moolenaar WH. Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 90: 1257-61. PMID 7679495 DOI: 10.1073/Pnas.90.4.1257  0.515
1992 Maassen JA, Burgering BM, Medema RH, Osterop AP, van der Zon GC, Möller W, Bos JL. The role of ras proteins in insulin signal transduction. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 24: 214-8. PMID 1398459 DOI: 10.1055/s-2007-1003296  0.438
1992 Medema RH, de Laat WL, Martin GA, McCormick F, Bos JL. GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion. Molecular and Cellular Biology. 12: 3425-30. PMID 1321335 DOI: 10.1128/Mcb.12.8.3425  0.487
1991 Medema RH, Wubbolts R, Bos JL. Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression. Molecular and Cellular Biology. 11: 5963-7. PMID 1658621 DOI: 10.1128/Mcb.11.12.5963  0.448
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