Jacek Hawiger - Publications

Microbiology and Immunology Vanderbilt University, Nashville, TN 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chiusa M, Hu W, Zienkiewicz J, Chen X, Zhang MZ, Harris RC, Vanacore RM, Bentz JA, Remuzzi G, Benigni A, Fogo AB, Luo W, Mili S, Wilson MH, Zent R, ... Hawiger J, et al. EGF receptor-mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling. The Journal of Cell Biology. 219. PMID 32678881 DOI: 10.1083/Jcb.202001120  0.3
2019 Hawiger J, Zienkiewicz J. Decoding Inflammation, Its Causes, Genomic Responses, and Emerging Countermeasures. Scandinavian Journal of Immunology. e12812. PMID 31378956 DOI: 10.1111/Sji.12812  0.33
2018 Hawiger J. Heartfelt sepsis: microvascular injury due to genomic storm. Kardiologia Polska. PMID 29974447 DOI: 10.5603/Kp.A2018.0146  0.302
2017 Veach RA, Liu Y, Zienkiewicz J, Wylezinski LS, Boyd KL, Wynn JL, Hawiger J. Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles. Plos One. 12: e0179468. PMID 28628637 DOI: 10.1371/Journal.Pone.0179468  0.352
2016 Wylezinski LS, Hawiger J. Interleukin 2 Activates Brain Microvascular Endothelial Cells Resulting in Destabilization of Adherens Junctions. The Journal of Biological Chemistry. 291: 22913-22923. PMID 27601468 DOI: 10.1074/Jbc.M116.729038  0.304
2016 Wynn JL, Wilson CS, Hawiger J, Scumpia PO, Marshall AF, Liu JH, Zharkikh I, Wong HR, Lahni P, Benjamin JT, Plosa EJ, Weitkamp JH, Sherwood ER, Moldawer LL, Ungaro R, et al. Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114524 DOI: 10.1073/Pnas.1515793113  0.523
2015 Hawiger J, Veach RA, Zienkiewicz J. New paradigms in sepsis: from prevention to protection of failing microcirculation Journal of Thrombosis and Haemostasis. 13: 1743-1756. PMID 26190521 DOI: 10.1111/Jth.13061  0.306
2014 DiGiandomenico A, Veach RA, Zienkiewicz J, Moore DJ, Wylezinski LS, Hutchens MA, Hawiger J. The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation. Plos One. 9: e110183. PMID 25329889 DOI: 10.1371/Journal.Pone.0110183  0.57
2014 Qiao H, Liu Y, Veach RA, Wylezinski L, Hawiger J. The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli. The Journal of Biological Chemistry. 289: 21973-83. PMID 24958727 DOI: 10.1074/Jbc.M114.588723  0.357
2013 Zienkiewicz J, Armitage A, Hawiger J. Targeting nuclear import shuttles, importins/karyopherins alpha by a peptide mimicking the NFκB1/p50 nuclear localization sequence. Journal of the American Heart Association. 2: e000386. PMID 24042087 DOI: 10.1161/Jaha.113.000386  0.328
2013 Sethman CR, Hawiger J. The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling. Plos One. 8: e70994. PMID 23923041 DOI: 10.1371/Journal.Pone.0070994  0.334
2013 Liu Y, Major AS, Zienkiewicz J, Gabriel CL, Veach RA, Moore DJ, Collins RD, Hawiger J. Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver. Journal of the American Heart Association. 2: e000093. PMID 23563994 DOI: 10.1161/Jaha.113.000093  0.512
2012 Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J, Ruley HE. Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 188: 2493-7. PMID 22323537 DOI: 10.4049/Jimmunol.1101502  0.569
2010 Moore DJ, Zienkiewicz J, Kendall PL, Liu D, Liu X, Veach RA, Collins RD, Hawiger J. In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes. Plos One. 5: e13235. PMID 20949090 DOI: 10.1371/Journal.Pone.0013235  0.531
2009 Liu D, Zienkiewicz J, DiGiandomenico A, Hawiger J. Suppression of acute lung inflammation by intracellular peptide delivery of a nuclear import inhibitor. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 796-802. PMID 19259070 DOI: 10.1038/Mt.2009.18  0.341
2008 Zanchi C, Zoja C, Morigi M, Valsecchi F, Liu XY, Rottoli D, Locatelli M, Buelli S, Pezzotta A, Mapelli P, Geelen J, Remuzzi G, Hawiger J. Fractalkine and CX3CR1 mediate leukocyte capture by endothelium in response to Shiga toxin. Journal of Immunology (Baltimore, Md. : 1950). 181: 1460-9. PMID 18606701 DOI: 10.4049/Jimmunol.181.2.1460  0.359
2006 Bezbradica JS, Gordy LE, Stanic AK, Dragovic S, Hill T, Hawiger J, Unutmaz D, Van Kaer L, Joyce S. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity. 25: 487-97. PMID 16949316 DOI: 10.1016/J.Immuni.2006.06.017  0.326
2005 Jo D, Liu D, Yao S, Collins RD, Hawiger J. Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis. Nature Medicine. 11: 892-8. PMID 16007096 DOI: 10.1038/Nm1269  0.344
2005 Li C, Zienkiewicz J, Hawiger J. Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway. The Journal of Biological Chemistry. 280: 26152-9. PMID 15849357 DOI: 10.1074/Jbc.M503262200  0.335
2004 Liu D, Li C, Chen Y, Burnett C, Liu XY, Downs S, Collins RD, Hawiger J. Nuclear import of proinflammatory transcription factors is required for massive liver apoptosis induced by bacterial lipopolysaccharide. The Journal of Biological Chemistry. 279: 48434-42. PMID 15345713 DOI: 10.1074/Jbc.M407190200  0.351
2004 Liu D, Liu XY, Robinson D, Burnett C, Jackson C, Seele L, Veach RA, Downs S, Collins RD, Ballard DW, Hawiger J. Suppression of Staphylococcal Enterotoxin B-induced Toxicity by a Nuclear Import Inhibitor. The Journal of Biological Chemistry. 279: 19239-46. PMID 14732709 DOI: 10.1074/Jbc.M313442200  0.364
2004 Veach RA, Liu D, Yao S, Chen Y, Liu XY, Downs S, Hawiger J. Receptor/transporter-independent targeting of functional peptides across the plasma membrane. The Journal of Biological Chemistry. 279: 11425-31. PMID 14699109 DOI: 10.1074/Jbc.M311089200  0.352
2001 Hawiger J. Innate immunity and inflammation: a transcriptional paradigm. Immunologic Research. 23: 99-109. PMID 11444396 DOI: 10.1385/Ir:23:2-3:099  0.363
2000 Liu XY, Robinson D, Veach RA, Liu D, Timmons S, Collins RD, Hawiger J. Peptide-directed Suppression of a Pro-inflammatory Cytokine Response Journal of Biological Chemistry. 275: 16774-16778. PMID 10751381 DOI: 10.1074/Jbc.C000083200  0.372
1999 Ware S, Donahue JP, Hawiger J, Anderson WF. Structure of the fibrinogen gamma-chain integrin binding and factor XIIIa cross-linking sites obtained through carrier protein driven crystallization. Protein Science : a Publication of the Protein Society. 8: 2663-71. PMID 10631982 DOI: 10.1110/Ps.8.12.2663  0.322
1999 Hawiger J. Noninvasive intracellular delivery of functional peptides and proteins. Current Opinion in Chemical Biology. 3: 89-94. PMID 10021415 DOI: 10.1016/S1367-5931(99)80016-7  0.334
1999 Hawiger J, Veach RA, Liu X, Timmons S, Ballard DW. IκB Kinase Complex Is an Intracellular Target for Endotoxic Lipopolysaccharide in Human Monocytic Cells Blood. 94: 1711-1716. DOI: 10.1182/Blood.V94.5.1711.417K20_1711_1716  0.346
1998 Zhang L, Torgerson TR, Liu X, Timmons S, Colosia AD, Hawiger J, Tam JP. Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules. Proceedings of the National Academy of Sciences of the United States of America. 95: 9184-9189. PMID 9689055 DOI: 10.1073/Pnas.95.16.9184  0.335
1998 Chu ZL, DiDonato JA, Hawiger J, Ballard DW. The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta. The Journal of Biological Chemistry. 273: 15891-4. PMID 9632633 DOI: 10.1074/Jbc.273.26.15891  0.314
1997 Hawiger J. Cellular import of functional peptides to block intracellular signaling Current Opinion in Immunology. 9: 189-194. PMID 9099795 DOI: 10.1016/S0952-7915(97)80134-3  0.355
1996 Liu X, Timmons S, Lin Y, Hawiger J. Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs Proceedings of the National Academy of Sciences of the United States of America. 93: 11819-11824. PMID 8876221 DOI: 10.1073/Pnas.93.21.11819  0.319
1996 Lin Y, Yao S, Hawiger J. Role of the Nuclear Localization Sequence in Fibroblast Growth Factor-1-stimulated Mitogenic Pathways Journal of Biological Chemistry. 271: 5305-5308. PMID 8621379 DOI: 10.1074/Jbc.271.10.5305  0.318
1995 Donald R, Ballard DW, Hawiger J. Proteolytic Processing of NF-B/IB in Human Monocytes ATP-DEPENDENT INDUCTION BY PRO-INFLAMMATORY MEDIATORS Journal of Biological Chemistry. 270: 9-12. PMID 7814425 DOI: 10.1074/Jbc.270.1.9  0.33
1995 Lin Y, Yao S, Veach RA, Torgerson TR, Hawiger J. Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence Journal of Biological Chemistry. 270: 14255-14258. PMID 7782278 DOI: 10.1074/Jbc.270.24.14255  0.358
1995 Hawiger J. Mechanisms involved in platelet vessel wall interaction. Thrombosis and Haemostasis. 74: 369-372. DOI: 10.1055/S-0038-1642704  0.359
1993 Read MA, Cordle SR, Veach RA, Carlisle CD, Hawiger J. Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopolysaccharide in human endothelial cells Proceedings of the National Academy of Sciences of the United States of America. 90: 9887-9891. PMID 7694295 DOI: 10.1073/Pnas.90.21.9887  0.32
1992 Hawiger J, Timmons S. Binding of fibrinogen and von Willebrand factor to platelet glycoprotein IIb-IIIa complex. Methods in Enzymology. 215: 228-243. PMID 1435324 DOI: 10.1016/0076-6879(92)15067-M  0.322
1992 Hawiger J. Repertoire of platelet receptors Methods in Enzymology. 215: 131-136. PMID 1435318 DOI: 10.1016/0076-6879(92)15058-K  0.313
1992 Blumenstein M, Matsueda GR, Timmons S, Hawiger J. A beta-turn is present in the 392-411 segment of the human fibrinogen gamma-chain. Effects of structural changes in this segment on affinity to antibody 4A5. Biochemistry. 31: 10692-10698. PMID 1420184 DOI: 10.1021/Bi00159A008  0.324
1991 Hawiger J. Adhesive Interactions of Platelets and Their Blockadea Annals of the New York Academy of Sciences. 614: 270-278. PMID 2024888 DOI: 10.1111/J.1749-6632.1991.Tb43709.X  0.39
1991 Chen CS, Hawiger J. Reactivity of synthetic peptide analogs of adhesive proteins in regard to the interaction of human endothelial cells with extracellular matrix. Blood. 77: 2200-2206. DOI: 10.1182/Blood.V77.10.2200.2200  0.324
1990 Bauer K, Kass B, Cate Ht, Hawiger J, Rosenberg R. Factor IX is activated in vivo by the tissue factor mechanism. Blood. 76: 731-736. DOI: 10.1182/Blood.V76.4.731.Bloodjournal764731  0.325
1989 Weiss HJ, Hawiger J, Ruggeri ZM, Turitto VT, Thiagarajan P, Hoffman T. Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate Journal of Clinical Investigation. 83: 288-297. PMID 2910912 DOI: 10.1172/Jci113871  0.373
1989 Timmons S, Bednarek MA, Kloczewiak M, Hawiger J. Antiplatelet "hybrid" peptides analogous to receptor recognition domains on gamma and alpha chains of human fibrinogen. Biochemistry. 28: 2919-2923. PMID 2742820 DOI: 10.1021/Bi00433A026  0.3
1989 Hawiger J, Kloczewiak M, Bednarek MA, Timmons S. Platelet receptor recognition domains on the .alpha. chain of human fibrinogen: structure-function analysis Biochemistry. 28: 2909-2914. PMID 2742818 DOI: 10.1021/Bi00433A024  0.357
1989 Timmons S, Hawiger J. Isolation of human platelets by albumin gradient and gel filtration. Methods in Enzymology. 169: 11-21. PMID 2716523 DOI: 10.1016/0076-6879(89)69046-5  0.331
1989 Hawiger J. Platelet secretory pathways: an overview Methods in Enzymology. 169: 191-195. PMID 2654559 DOI: 10.1016/0076-6879(89)69059-3  0.342
1989 Bauer K, Kass B, Cate Ht, Bednarek M, Hawiger J, Rosenberg R. Detection of factor X activation in humans. Blood. 74: 2007-2015. DOI: 10.1182/Blood.V74.6.2007.2007  0.322
1989 Kloczewiak M, Timmons S, Bednarek MA, Sakon M, Hawiger J. Platelet receptor recognition domain on the .gamma. chain of human fibrinogen and its synthetic peptide analogs [Erratum to document cited in CA110(17):151810E] Biochemistry. 28: 7974-7974. DOI: 10.1021/Bi00445A065  0.33
1988 Grabarek J, Timmons S, Hawiger J. Modulation of human platelet protein kinase C by endotoxic lipid A. Journal of Clinical Investigation. 82: 964-971. PMID 3047171 DOI: 10.1172/Jci113705  0.336
1987 Hawiger J. Formation and regulation of platelet and fibrin hemostatic plug Human Pathology. 18: 111-122. PMID 3804319 DOI: 10.1016/S0046-8177(87)80330-1  0.392
1987 Hawiger J. Macromolecules That Link Platelets following Vessel Wall Injurya Annals of the New York Academy of Sciences. 509: 131-141. PMID 2827552 DOI: 10.1111/J.1749-6632.1987.Tb30990.X  0.379
1986 Timmons S, Huzoor-Akbar, Grabarek J, Kloczewiak M, Hawiger J. Mechanism of human platelet activation by endotoxic glycolipid-bearing mutant Re595 of Salmonella minnesota Blood. 68: 1015-1023. DOI: 10.1182/Blood.V68.5.1015.Bloodjournal6851015  0.379
1986 McManama G, Lindon J, Kloczewiak M, Smith M, Ware J, Hawiger J, Merrill E, Salzman E. Platelet aggregation by fibrinogen polymers crosslinked across the E domain Blood. 68: 363-371. DOI: 10.1182/Blood.V68.2.363.363  0.357
1984 Kloczewiak M, Timmons S, Lukas TJ, Hawiger J. Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the gamma chain. Biochemistry. 23: 1767-1774. PMID 6326808 DOI: 10.1021/Bi00303A028  0.36
1984 Timmons S, Kloczewiak M, Hawiger J. ADP-dependent common receptor mechanism for binding of von Willebrand factor and fibrinogen to human platelets. Proceedings of the National Academy of Sciences of the United States of America. 81: 4935-4939. PMID 6087354 DOI: 10.1073/Pnas.81.15.4935  0.365
1983 Kloczewiak M, Timmons S, Hawiger J. Recognition site for the platelet receptor is present on the 15-residue carboxy-terminal fragment of the γ chain of human fibrinogen and is not involved in the fibrin polymerization reaction Thrombosis Research. 29: 249-254. PMID 6302942 DOI: 10.1016/0049-3848(83)90147-0  0.376
1983 Hawiger J, Kloczewiak M, Timmons S, Strong D, Doolittle RF. Interaction of fibrinogen with staphylococcal clumping factor and with platelets. Annals of the New York Academy of Sciences. 408: 521-35. PMID 6223560 DOI: 10.1111/J.1749-6632.1983.Tb23270.X  0.375
1982 Kloczewiak M, Timmons S, Hawiger J. Localization of a site interacting with human platelet receptor on carboxy-terminal segment of human fibrinogen γ chain Biochemical and Biophysical Research Communications. 107: 181-187. PMID 6289817 DOI: 10.1016/0006-291X(82)91686-2  0.386
1982 Fujimoto T, Ohara S, Hawiger J. Thrombin-induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets. Journal of Clinical Investigation. 69: 1212-1222. PMID 6282932 DOI: 10.1172/Jci110560  0.345
1982 Hawiger J, Timmons S, Kloczewiak M, Strong DD, Doolittle RF. γ and α chains of human fibrinogen possess sites reactive with human platelet receptors Proceedings of the National Academy of Sciences of the United States of America. 79: 2068-2071. PMID 6281794 DOI: 10.1073/Pnas.79.6.2068  0.367
1980 Des Prez RM, Steckley S, Stroud RM, Hawiger J. Interaction of Histoplasma capsulatum with human platelets. The Journal of Infectious Diseases. 142: 32-9. PMID 7400626 DOI: 10.1093/Infdis/142.1.32  0.344
1977 Hawiger J, Hawiger A, Steckley S, Timmons S, Cheng C. Membrane Changes in Human Platelets Induced by Lipopolysaccharide Endotoxin British Journal of Haematology. 35: 285-299. PMID 322697 DOI: 10.1111/J.1365-2141.1977.Tb00585.X  0.373
1975 Hawiger J, Hawiger A, Timmons S. Endotoxin-sensitive membrane component of human platelets. Nature. 256: 125-127. PMID 1097934 DOI: 10.1038/256125A0  0.363
1972 Hawiger J, Marney SR, Colley DG, Des Prez RM. Complement-dependent platelet injury by staphylococcal protein A. The Journal of Experimental Medicine. 136: 68-80. PMID 4624450 DOI: 10.1084/Jem.136.1.68  0.343
1969 Hawiger J, Collins RD, Horn RG. Precipitation of soluble fibrin monomer complexes by lysosomal protein fraction of polymorphonuclear leukocytes. Experimental Biology and Medicine. 131: 349-353. PMID 5787109 DOI: 10.3181/00379727-131-33875  0.305
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