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James E. Bear, Ph.D. - Publications

Affiliations: 
Cell and Developmental Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
cell migration
Website:
http://www.med.unc.edu/cellbiophysio/faculty/bear

92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Chandra A, Butler MT, Bear JE, Haugh JM. Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling. Biophysical Journal. 121: 102-118. PMID 34861242 DOI: 10.1016/j.bpj.2021.11.2889  0.35
2020 Eckly A, Scandola C, Oprescu A, Michel D, Rinckel JY, Proamer F, Hoffmann D, Receveur N, Léon C, Bear JE, Ghalloussi D, Harousseau G, Bergmeier W, Lanza F, Gaits-Iacovoni F, et al. Megakaryocytes use in vivo podosome-like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids. Journal of Thrombosis and Haemostasis : Jth. PMID 32702204 DOI: 10.1111/Jth.15024  0.315
2020 Nosbisch JL, Rahman A, Mohan K, Elston TC, Bear JE, Haugh JM. Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing. Plos Computational Biology. 16: e1007708. PMID 32255775 DOI: 10.1371/Journal.Pcbi.1007708  0.394
2020 Tessier S, Doolittle AC, Sao K, Rotty JD, Bear JE, Ulici V, Loeser RF, Shapiro IM, Diekman BO, Risbud MV. Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. Jci Insight. PMID 31961823 DOI: 10.1172/Jci.Insight.131382  0.391
2019 Miller CJ, LaFosse PK, Asokan SB, Haugh JM, Bear JE, Elston TC. Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 31365063 DOI: 10.1093/Intbio/Zyz023  0.39
2018 Castagnino A, Castro-Castro A, Irondelle M, Guichard A, Lodillinsky C, Fuhrmann L, Vacher S, Agüera-González S, Zagryazhskaya-Masson A, Romao M, El Kesrouani C, Noegel AA, Dubois T, Raposo G, Bear JE, et al. Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function. Oncogene. PMID 30065298 DOI: 10.1038/S41388-018-0422-X  0.322
2018 Graham DM, Andersen T, Sharek L, Uzer G, Rothenberg K, Hoffman BD, Rubin J, Balland M, Bear JE, Burridge K. Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction. The Journal of Cell Biology. PMID 29351995 DOI: 10.1083/Jcb.201706097  0.613
2017 Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE, Weyrich AS, Bear JE, et al. Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood Advances. 1: 1398-1408. PMID 29104956 DOI: 10.1182/Bloodadvances.2017006973  0.527
2017 Rotty JD, Brighton HE, Craig SL, Asokan SB, Cheng N, Ting JP, Bear JE. Arp2/3 Complex Is Required for Macrophage Integrin Functions but Is Dispensable for FcR Phagocytosis and In Vivo Motility. Developmental Cell. PMID 28867487 DOI: 10.1016/J.Devcel.2017.08.003  0.468
2017 Zimmerman SP, Asokan SB, Kuhlman B, Bear JE. Cells lay their own tracks: optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration. Journal of Cell Science. PMID 28754687 DOI: 10.1242/Jcs.205948  0.434
2017 Shutova MS, Asokan SB, Talwar S, Assoian RK, Bear JE, Svitkina TM. Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility. The Journal of Cell Biology. PMID 28701425 DOI: 10.1083/Jcb.201705167  0.426
2017 Mohan K, Nosbisch JL, Elston TC, Bear JE, Haugh JM. A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis. Biophysical Journal. 113: 185-194. PMID 28700916 DOI: 10.1016/J.Bpj.2017.05.035  0.36
2016 Qu F, Lorenzo DN, King SJ, Brooks R, Bear JE, Bennett V. Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. Elife. 5. PMID 27718357 DOI: 10.7554/Elife.20417  0.447
2016 Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB. MenaINV mediates synergistic crosstalk between signaling pathways driving chemotaxis and haptotaxis. Molecular Biology of the Cell. PMID 27559126 DOI: 10.1091/Mbc.E16-04-0212  0.637
2016 Zimmerman SP, Hallett R, Bourke AM, Bear JE, Kennedy MJ, Kuhlman B. Tuning the Binding Affinities and Reversion Kinetics of a Light Inducible Dimer Allows Control of Transmembrane Protein Localization. Biochemistry. PMID 27529180 DOI: 10.1021/Acs.Biochem.6B00529  0.306
2016 Liu X, Asokan SB, Bear JE, Haugh JM. Quantitative analysis of B-lymphocyte migration directed by CXCL13. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 27477203 DOI: 10.1039/C6Ib00128A  0.406
2016 King SJ, Asokan SB, Haynes EM, Zimmerman SP, Rotty JD, Alb JG, Tagliatela A, Blake DR, Lebedeva IP, Marston D, Johnson HE, Parsons M, Sharpless NE, Kuhlman B, Haugh JM, ... Bear JE, et al. Lamellipodia are critical for haptotactic sensing and response. Journal of Cell Science. PMID 27173494 DOI: 10.1242/Jcs.184507  0.473
2016 Brayford S, Bryce NS, Schevzov G, Haynes EM, Bear JE, Hardeman EC, Gunning PW. Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge. Current Biology : Cb. PMID 27112294 DOI: 10.1016/J.Cub.2016.03.028  0.541
2016 Yumerefendi H, Lerner AM, Zimmerman SP, Hahn K, Bear JE, Strahl BD, Kuhlman B. Light-induced nuclear export reveals rapid dynamics of epigenetic modifications. Nature Chemical Biology. PMID 27089030 DOI: 10.1038/Nchembio.2068  0.525
2016 Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, ... ... Bear JE, et al. Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression. Cancer Discovery. PMID 26811325 DOI: 10.1158/2159-8290.Cd-15-1183  0.595
2016 Qu F, Lorenzo DN, King SJ, Brooks R, Bear JE, Bennett V. Author response: Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes Elife. DOI: 10.7554/Elife.20417.022  0.318
2016 Oudin MJ, Jonas O, Kosciuk T, Broye L, Wyckoff J, Klazen J, Lamar J, Asokan S, Whittaker C, Langer R, Cima M, Wisinski K, Hynes R, Lauffenburger D, Keely P, ... Bear J, et al. Abstract PR15: Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-Pr15  0.616
2016 Allen JL, Walk EL, Rhodes KL, Beatty CJ, Markwell SM, Papenberg BW, Interval ET, Wu H, Garcia MV, Bear JE, Weed SA. Abstract 5064: CORO1B amplification and expression status identifies an aggressive subset of chromosome 11q13 amplified HNSCC Cancer Research. 76: 5064-5064. DOI: 10.1158/1538-7445.Am2016-5064  0.379
2015 Creed SJ, Le CP, Hassan M, Pon CK, Albold S, Chan KT, Berginski ME, Huang Z, Bear JE, Lane JR, Halls ML, Ferrari D, Nowell CJ, Sloan EK. β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion. Breast Cancer Research : Bcr. 17: 145. PMID 26607426 DOI: 10.1186/S13058-015-0655-3  0.401
2015 Hallett RA, Zimmerman SP, Yumerefendi H, Bear JE, Kuhlman B. Correlating in Vitro and in Vivo Activities of Light-Inducible Dimers: A Cellular Optogenetics Guide. Acs Synthetic Biology. PMID 26474029 DOI: 10.1021/Acssynbio.5B00119  0.33
2015 Rotty JD, Bear JE. Competition and Collaboration Between Different Actin Assembly Pathways Allows for Homeostatic Control of the Actin Cytoskeleton. Bioarchitecture. 0. PMID 26430713 DOI: 10.1080/19490992.2015.1090670  0.398
2015 Scott DW, Tolbert CE, Graham DM, Wittchen E, Bear JE, Burridge K. N-glycosylation controls the function of the Junctional Adhesion Molecule-A. Molecular Biology of the Cell. PMID 26224316 DOI: 10.1091/Mbc.E14-12-1604  0.581
2015 Andrade DM, Clausen MP, Keller J, Mueller V, Wu C, Bear JE, Hell SW, Lagerholm BC, Eggeling C. Cortical actin networks induce spatio-temporal confinement of phospholipids in the plasma membrane - a minimally invasive investigation by STED-FCS. Scientific Reports. 5: 11454. PMID 26118385 DOI: 10.1038/Srep11454  0.542
2015 Haynes EM, Asokan SB, King SJ, Johnson HE, Haugh JM, Bear JE. GMFβ controls branched actin content and lamellipodial retraction in fibroblasts. The Journal of Cell Biology. 209: 803-12. PMID 26101216 DOI: 10.1083/Jcb.201501094  0.503
2015 Yumerefendi H, Dickinson DJ, Wang H, Zimmerman SP, Bear JE, Goldstein B, Hahn K, Kuhlman B. Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation. Plos One. 10: e0128443. PMID 26083500 DOI: 10.1371/Journal.Pone.0128443  0.58
2015 Johnson HE, King SJ, Asokan SB, Rotty JD, Bear JE, Haugh JM. F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling. The Journal of Cell Biology. 208: 443-55. PMID 25666809 DOI: 10.1083/Jcb.201406102  0.452
2015 Rotty JD, Wu C, Haynes EM, Suarez C, Winkelman JD, Johnson HE, Haugh JM, Kovar DR, Bear JE. Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways. Developmental Cell. 32: 54-67. PMID 25543281 DOI: 10.1016/J.Devcel.2014.10.026  0.624
2015 Guntas G, Hallett RA, Zimmerman SP, Williams T, Yumerefendi H, Bear JE, Kuhlman B. Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins. Proceedings of the National Academy of Sciences of the United States of America. 112: 112-7. PMID 25535392 DOI: 10.1073/Pnas.1417910112  0.329
2015 Oudin MJ, Miller MA, Kosciuk T, Klazen J, Lussiez A, Lauffenburger D, Bear JE, Gertler FB. Abstract 5057: Mena at the nexus of chemotaxis and haptotaxis during tumor progression Cancer Research. 76: 5057-5057. DOI: 10.1158/1538-7445.Am2016-5057  0.641
2014 Asokan SB, Johnson HE, Rahman A, King SJ, Rotty JD, Lebedeva IP, Haugh JM, Bear JE. Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway. Developmental Cell. 31: 747-60. PMID 25482883 DOI: 10.1016/J.Devcel.2014.10.024  0.433
2014 Chan KT, Asokan SB, King SJ, Bo T, Dubose ES, Liu W, Berginski ME, Simon JM, Davis IJ, Gomez SM, Sharpless NE, Bear JE. LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues. The Journal of Cell Biology. 207: 299-315. PMID 25349262 DOI: 10.1083/Jcb.201404067  0.394
2014 Berginski ME, Creed SJ, Cochran S, Roadcap DW, Bear JE, Gomez SM. Automated analysis of invadopodia dynamics in live cells. Peerj. 2: e462. PMID 25071988 DOI: 10.7717/Peerj.462  0.394
2014 Bear JE, Haugh JM. Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet. Current Opinion in Cell Biology. 30: 74-82. PMID 24999834 DOI: 10.1016/J.Ceb.2014.06.005  0.468
2014 Fulton LM, Taylor NA, Coghill JM, West ML, Föger N, Bear JE, Baldwin AS, Panoskaltsis-Mortari A, Serody JS. Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease. European Journal of Immunology. 44: 1662-71. PMID 24752751 DOI: 10.1002/Eji.201344155  0.331
2014 Lin KL, Fulton LM, Berginski M, West ML, Taylor NA, Moran TP, Coghill JM, Blazar BR, Bear JE, Serody JS. Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD. Blood. 123: 1604-14. PMID 24415540 DOI: 10.1182/Blood-2013-09-526020  0.301
2014 Roode L, Bo T, Perry J, Luft JC, Bear JE, Davis IJ, DeSimone JM. Abstract 5401: Investigation of sub-tumor accumulation of PRINT nanoparticles reveals dose and route of administration dependence on particle association Cancer Research. 74: 5401-5401. DOI: 10.1158/1538-7445.Am2014-5401  0.302
2014 Oudin MJ, Broye LC, Lussiez A, Asokan SB, Miller MA, Lauffenburger DA, Bear JE, Gertler FB. Abstract 1988: MenaINV interaction with α5β1 promotes tumor cell invasion in response to gradients of growth factors and fibronectin Cancer Research. 74: 1988-1988. DOI: 10.1158/1538-7445.Am2014-1988  0.632
2013 Wu C, Haynes EM, Asokan SB, Simon JM, Sharpless NE, Baldwin AS, Davis IJ, Johnson GL, Bear JE. Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling. The Journal of Cell Biology. 203: 907-16. PMID 24344184 DOI: 10.1083/Jcb.201306032  0.595
2013 Mitin N, Rossman KL, Currin R, Anne S, Marshall TW, Bear JE, Bautch VL, Der CJ. The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility. Plos One. 8: e66260. PMID 23825001 DOI: 10.1371/Journal.Pone.0066260  0.688
2013 Usatyuk PV, Burns M, Mohan V, Pendyala S, He D, Ebenezer DL, Harijith A, Fu P, Huang LS, Bear JE, Garcia JG, Natarajan V. Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. Plos One. 8: e63007. PMID 23667561 DOI: 10.1371/Journal.Pone.0063007  0.448
2013 Rotty JD, Wu C, Bear JE. New insights into the regulation and cellular functions of the ARP2/3 complex. Nature Reviews. Molecular Cell Biology. 14: 7-12. PMID 23212475 DOI: 10.1038/Nrm3492  0.619
2013 Oudin MJ, Hughes-Alford SK, Miller M, Asokan SB, Bear JE, Lauffenburger DA, Gertler FB. Abstract C41: MenaINVdysregulation of receptor tyrosine kinase signaling Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-C41  0.634
2013 Chan KT, Asokan SB, Bo T, Berginski ME, Liu W, Cochran SD, Sharpless NE, Bear JE. Abstract C14: Loss of haptotaxis facilitates invasion in LKB1-deficient melanoma Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-C14  0.359
2013 Debebe Z, Porter M, Hull-Ryde EE, Rasmussen N, Sendor A, Norris-Drouin J, Chan K, Bear JE, Janzen WP, Rathmell K. Abstract B206: Ror2 as a therapeutic target in renal cell carcinoma and other invasive cancers. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B206  0.398
2012 Gach PC, Xu W, King SJ, Sims CE, Bear J, Allbritton NL. Microfabricated arrays for splitting and assay of clonal colonies. Analytical Chemistry. 84: 10614-20. PMID 23153031 DOI: 10.1021/Ac301895T  0.34
2012 Liu W, Monahan KB, Pfefferle AD, Shimamura T, Sorrentino J, Chan KT, Roadcap DW, Ollila DW, Thomas NE, Castrillon DH, Miller CR, Perou CM, Wong KK, Bear JE, Sharpless NE. LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell. 21: 751-64. PMID 22698401 DOI: 10.1016/J.Ccr.2012.03.048  0.301
2012 Williams HC, San Martín A, Adamo CM, Seidel-Rogol B, Pounkova L, Datla SR, Lassègue B, Bear JE, Griendling K. Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells. Circulation Research. 111: 56-65. PMID 22619279 DOI: 10.1161/Circresaha.111.255745  0.367
2012 Wu C, Asokan SB, Berginski ME, Haynes EM, Sharpless NE, Griffith JD, Gomez SM, Bear JE. Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell. 148: 973-87. PMID 22385962 DOI: 10.1016/J.Cell.2011.12.034  0.604
2012 Chan KT, Roadcap DW, Holoweckyj N, Bear JE. Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin. The Biochemical Journal. 444: 89-96. PMID 22364218 DOI: 10.1042/Bj20120209  0.416
2011 Roney KE, O'Connor BP, Wen H, Holl EK, Guthrie EH, Davis BK, Jones SW, Jha S, Sharek L, Garcia-Mata R, Bear JE, Ting JP. Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. Plos One. 6: e24795. PMID 21966369 DOI: 10.1371/Journal.Pone.0024795  0.444
2011 Chan KT, Creed SJ, Bear JE. Unraveling the enigma: progress towards understanding the coronin family of actin regulators. Trends in Cell Biology. 21: 481-8. PMID 21632254 DOI: 10.1016/J.Tcb.2011.04.004  0.483
2011 Lin KL, West ML, Coghill J, Jones S, Bear JE, Serody JS. In Vivo Assessment of T Effector, T Regulatory Cell, Dendritic Cell Interaction in Lymphoid Tissue Using Intravital Imaging During Acute GvHD Blood. 118: 818-818. DOI: 10.1182/Blood.V118.21.818.818  0.307
2011 Fulton LM, Coghill J, West ML, Foger N, Bear J, Serody JS. Impaired Donor T Cell Egress From Recipient Lymphoid Tissue Profoundly Diminishes Acute GvHD, Blood. 118: 4022-4022. DOI: 10.1182/Blood.V118.21.4022.4022  0.329
2011 Walk EL, Wu H, Garcia MV, Bear JE, Weed SA. Abstract 4752: Cortactin and coronin 1B cooperate to promote tumor cell invasion in head and neck squamous cell carcinoma Cancer Research. 71: 4752-4752. DOI: 10.1158/1538-7445.Am2011-4752  0.46
2010 Rozenberg GI, Monahan KB, Torrice C, Bear JE, Sharpless NE. Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation. Melanoma Research. 20: 361-71. PMID 20679910 DOI: 10.1097/Cmr.0B013E328336Ee17  0.342
2009 Uetrecht AC, Bear JE. Golgi polarity does not correlate with speed or persistence of freely migrating fibroblasts. European Journal of Cell Biology. 88: 711-7. PMID 19726103 DOI: 10.1016/J.Ejcb.2009.08.001  0.781
2009 Marshall TW, Aloor HL, Bear JE. Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. Journal of Cell Science. 122: 3061-9. PMID 19654210 DOI: 10.1242/Jcs.051482  0.61
2009 Bear JE, Gertler FB. Ena/VASP: towards resolving a pointed controversy at the barbed end. Journal of Cell Science. 122: 1947-53. PMID 19494122 DOI: 10.1242/Jcs.038125  0.667
2009 Roadcap DW, Bear JE. Double JMY: making actin fast. Nature Cell Biology. 11: 375-6. PMID 19337319 DOI: 10.1038/Ncb0409-375  0.5
2008 Shiow LR, Roadcap DW, Paris K, Watson SR, Grigorova IL, Lebet T, An J, Xu Y, Jenne CN, Föger N, Sorensen RU, Goodnow CC, Bear JE, Puck JM, Cyster JG. The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nature Immunology. 9: 1307-15. PMID 18836449 DOI: 10.1038/Ni.1662  0.411
2008 Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cell. 134: 828-42. PMID 18775315 DOI: 10.1016/J.Cell.2008.06.054  0.75
2008 Rybakin V, Rastetter RH, Stumpf M, Uetrecht AC, Bear JE, Noegel AA, Clemen CS. Molecular mechanism underlying the association of Coronin-7 with Golgi membranes. Cellular and Molecular Life Sciences : Cmls. 65: 2419-30. PMID 18581049 DOI: 10.1007/S00018-008-8278-9  0.775
2008 Bear JE. Follow the monomer. Cell. 133: 765-7. PMID 18510919 DOI: 10.1016/J.Cell.2008.05.012  0.479
2008 Liu Y, Boukhelifa M, Tribble E, Morin-Kensicki E, Uetrecht A, Bear JE, Bankaitis VA. The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals. Molecular Biology of the Cell. 19: 3080-96. PMID 18480408 DOI: 10.1091/Mbc.E07-12-1290  0.772
2008 Cai L, Bear JE. Peering deeply inside the branch. The Journal of Cell Biology. 180: 853-5. PMID 18316414 DOI: 10.1083/Jcb.200802062  0.545
2007 Cai L, Makhov AM, Bear JE. F-actin binding is essential for coronin 1B function in vivo. Journal of Cell Science. 120: 1779-90. PMID 17456547 DOI: 10.1242/Jcs.007641  0.564
2007 Vitriol EA, Uetrecht AC, Shen F, Jacobson K, Bear JE. Enhanced EGFP-chromophore-assisted laser inactivation using deficient cells rescued with functional EGFP-fusion proteins. Proceedings of the National Academy of Sciences of the United States of America. 104: 6702-7. PMID 17420475 DOI: 10.1073/Pnas.0701801104  0.79
2007 Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cell. 128: 915-29. PMID 17350576 DOI: 10.1016/J.Cell.2007.01.031  0.769
2007 Shields JM, Thomas NE, Cregger M, Berger AJ, Leslie M, Torrice C, Hao H, Penland S, Arbiser J, Scott G, Zhou T, Bar-Eli M, Bear JE, Der CJ, Kaufmann WK, et al. Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. Cancer Research. 67: 1502-12. PMID 17308088 DOI: 10.1158/0008-5472.Can-06-3311  0.334
2006 Uetrecht AC, Bear JE. Coronins: the return of the crown. Trends in Cell Biology. 16: 421-6. PMID 16806932 DOI: 10.1016/J.Tcb.2006.06.002  0.807
2006 Marshall TW, Cai L, Bear JE. Chemistry comes to the cell: ASCB 2005. Nature Chemical Biology. 2: 119-22. PMID 16484998 DOI: 10.1038/Nchembio0306-119  0.625
2005 Cai L, Holoweckyj N, Schaller MD, Bear JE. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. The Journal of Biological Chemistry. 280: 31913-23. PMID 16027158 DOI: 10.1074/Jbc.M504146200  0.704
2004 Boukhelifa M, Parast MM, Bear JE, Gertler FB, Otey CA. Palladin is a novel binding partner for Ena/VASP family members. Cell Motility and the Cytoskeleton. 58: 17-29. PMID 14983521 DOI: 10.1002/Cm.10173  0.625
2004 Bear JE. Cell Motility Moves Ahead Developmental Cell. 7: 165-166. DOI: 10.1016/J.Devcel.2004.07.011  0.475
2003 Krause M, Dent EW, Bear JE, Loureiro JJ, Gertler FB. Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annual Review of Cell and Developmental Biology. 19: 541-64. PMID 14570581 DOI: 10.1146/Annurev.Cellbio.19.050103.103356  0.705
2003 Apostol BL, Kazantsev A, Raffioni S, Illes K, Pallos J, Bodai L, Slepko N, Bear JE, Gertler FB, Hersch S, Housman DE, Marsh JL, Thompson LM. A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 100: 5950-5. PMID 12730384 DOI: 10.1073/Pnas.2628045100  0.551
2002 Krause M, Bear JE, Loureiro JJ, Gertler FB. The Ena/VASP enigma. Journal of Cell Science. 115: 4721-6. PMID 12432060 DOI: 10.1242/Jcs.00218  0.662
2002 Bear JE. Formins: taking a ride on the barbed end. Developmental Cell. 3: 149-50. PMID 12194842 DOI: 10.1016/S1534-5807(02)00230-7  0.427
2002 Loureiro JJ, Rubinson DA, Bear JE, Baltus GA, Kwiatkowski AV, Gertler FB. Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Molecular Biology of the Cell. 13: 2533-46. PMID 12134088 DOI: 10.1091/Mbc.E01-10-0102  0.695
2002 Geese M, Loureiro JJ, Bear JE, Wehland J, Gertler FB, Sechi AS. Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization. Molecular Biology of the Cell. 13: 2383-96. PMID 12134077 DOI: 10.1091/Mbc.E02-01-0058  0.692
2002 Bear JE, Svitkina TM, Krause M, Schafer DA, Loureiro JJ, Strasser GA, Maly IV, Chaga OY, Cooper JA, Borisy GG, Gertler FB. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell. 109: 509-21. PMID 12086607 DOI: 10.1016/S0092-8674(02)00731-6  0.803
2002 Kazantsev A, Walker HA, Slepko N, Bear JE, Preisinger E, Steffan JS, Zhu YZ, Gertler FB, Housman DE, Marsh JL, Thompson LM. A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nature Genetics. 30: 367-76. PMID 11925563 DOI: 10.1038/Ng864  0.55
2001 Seastone DJ, Harris E, Temesvari LA, Bear JE, Saxe CL, Cardelli J. The WASp-like protein scar regulates macropinocytosis, phagocytosis and endosomal membrane flow in Dictyostelium. Journal of Cell Science. 114: 2673-83. PMID 11683394  0.742
2001 Bear JE, Krause M, Gertler FB. Regulating cellular actin assembly. Current Opinion in Cell Biology. 13: 158-66. PMID 11248549 DOI: 10.1016/S0955-0674(00)00193-9  0.682
2000 Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB. cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. The Journal of Biological Chemistry. 275: 36143-51. PMID 10945997 DOI: 10.1074/Jbc.M006274200  0.654
2000 Bear JE, Loureiro JJ, Libova I, Fässler R, Wehland J, Gertler FB. Negative regulation of fibroblast motility by Ena/VASP proteins. Cell. 101: 717-28. PMID 10892743 DOI: 10.1016/S0092-8674(00)80884-3  0.678
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