Serge Roche - Publications

Affiliations: 
Université de Montpellier I. UFR des sciences pharmaceutiques et biologiques (1968-2014) 
Area:
Colorectal cancer, Collagen receptor DDR1, Metastases, , Tyrosine kinase, Adaptor protein, Signaling, Tyrosine kinases, Phosphoproteomic, Cell invasion

95 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lecointre C, Fourgous E, Montarras I, Kerneur C, Simon V, Boublik Y, Bonenfant D, Robert B, Martineau P, Roche S. Oncogenic Signalling of PEAK2 Pseudokinase in Colon Cancer. Cancers. 14. PMID 35740644 DOI: 10.3390/cancers14122981  0.481
2022 Aponte E, Lafitte M, Sirvent A, Simon V, Barbery M, Fourgous E, Boublik Y, Maffei M, Armand F, Hamelin R, Pannequin J, Fort P, Pons M, Roche S. Regulation of Src tumor activity by its N-terminal intrinsically disordered region. Oncogene. 41: 960-970. PMID 34999732 DOI: 10.1038/s41388-021-02092-x  0.452
2021 Ounoughene Y, Fourgous E, Boublik Y, Saland E, Guiraud N, Recher C, Urbach S, Fort P, Sarry JE, Fesquet D, Roche S. SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase. Cancers. 13. PMID 34944965 DOI: 10.3390/cancers13246344  0.465
2020 Sirvent A, Mevizou R, Naim D, Lafitte M, Roche S. Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis. Cancers. 12. PMID 32717909 DOI: 10.3390/Cancers12082014  0.588
2020 Lafitte M, Sirvent A, Roche S. Collagen Kinase Receptors as Potential Therapeutic Targets in Metastatic Colon Cancer. Frontiers in Oncology. 10: 125. PMID 32117772 DOI: 10.3389/Fonc.2020.00125  0.417
2019 Lafitte M, Lecointre C, Roche S. Roles of exosomes in metastatic colon cancer. American Journal of Physiology. Cell Physiology. PMID 31291143 DOI: 10.1152/Ajpcell.00218.2019  0.402
2019 Mevizou R, Sirvent A, Roche S. Control of Tyrosine Kinase Signalling by Small Adaptors in Colorectal Cancer. Cancers. 11. PMID 31091767 DOI: 10.3390/Cancers11050669  0.558
2019 Roche S, Lecointre C, Simon V, Labesse G. SHEDding light on the role of Pragmin pseudo-kinases in cancer. American Journal of Cancer Research. 9: 449-454. PMID 30906642  0.455
2018 Lecointre C, Simon V, Kerneur C, Allemand F, Fournet A, Montarras I, Pons JL, Gelin M, Brignatz C, Urbach S, Labesse G, Roche S. Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation. Structure (London, England : 1993). 26: 1563. PMID 30403993 DOI: 10.1016/j.str.2018.10.020  0.416
2018 Sirvent A, Lafitte M, Roche S. DDR1 inhibition as a new therapeutic strategy for colorectal cancer. Molecular & Cellular Oncology. 5: e1465882. PMID 30250919 DOI: 10.1080/23723556.2018.1465882  0.554
2018 Lecointre C, Simon V, Kerneur C, Allemand F, Fournet A, Montarras I, Pons JL, Gelin M, Brignatz C, Urbach S, Labesse G, Roche S. Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation. Structure (London, England : 1993). PMID 29503074 DOI: 10.1016/J.Str.2018.01.017  0.543
2018 Jeitany M, Leroy C, Tosti P, Lafitte M, Le Guet J, Simon V, Bonenfant D, Robert B, Grillet F, Mollevi C, El Messaoudi S, Otandault A, Canterel-Thouennon L, Busson M, Thierry AR, ... ... Roche S, et al. Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer. Embo Molecular Medicine. PMID 29438985 DOI: 10.15252/Emmm.201707918  0.834
2017 Imjeti NS, Menck K, Egea-Jimenez AL, Lecointre C, Lembo F, Bouguenina H, Badache A, Ghossoub R, David G, Roche S, Zimmermann P. Syntenin mediates SRC function in exosomal cell-to-cell communication. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109268 DOI: 10.1073/Pnas.1713433114  0.492
2017 Arbesú M, Maffei M, Cordeiro TN, Teixeira JM, Pérez Y, Bernadó P, Roche S, Pons M. The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases. Structure (London, England : 1993). PMID 28319009 DOI: 10.1016/J.Str.2017.02.011  0.326
2016 Chevalier C, Roche S, Bénistant C. Vesicular trafficking regulators are new players in breast cancer progression: Role of TOM1L1 in ERBB2-dependent invasion. Molecular & Cellular Oncology. 3: e1182241. PMID 27652326 DOI: 10.1080/23723556.2016.1182241  0.357
2016 Chevalier C, Collin G, Descamps S, Touaitahuata H, Simon V, Reymond N, Fernandez L, Milhiet PE, Georget V, Urbach S, Lasorsa L, Orsetti B, Boissière-Michot F, Lopez-Crapez E, Theillet C, ... Roche S, et al. TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion. Nature Communications. 7: 10765. PMID 26899482 DOI: 10.1038/Ncomms10765  0.797
2016 Naudin C, Chevalier C, Roche S. The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancer. Oncotarget. 7: 11033-55. PMID 26788993 DOI: 10.18632/Oncotarget.6929  0.75
2016 Tosti P, Leroy C, Jeitany M, Simon V, Bonenfant D, Thouennon L, Elmessaoudi S, Mollevi C, Thierry A, Martineau P, Robert B, Sirvent A, Roche S. The anti-leukemic drug nilotinib inhibits metastatic properties of colorectal cancer cells by targeting the receptor tyrosine kinase DDR1 European Journal of Cancer. 61: S148-S149. DOI: 10.1016/S0959-8049(16)61524-1  0.779
2015 Dubois F, Leroy C, Simon V, Benistant C, Roche S. YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells. American Journal of Cancer Research. 5: 1972-87. PMID 26269757  0.789
2015 Gioia R, Trégoat C, Dumas PY, Lagarde V, Prouzet-Mauléon V, Desplat V, Sirvent A, Praloran V, Lippert E, Villacreces A, Leconet W, Robert B, Vigon I, Roche S, Mahon FX, et al. CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-resistant chronic myeloid leukaemia. The Journal of Pathology. 237: 14-24. PMID 25965880 DOI: 10.1002/Path.4561  0.502
2015 Chevalier C, Cannet A, Descamps S, Sirvent A, Simon V, Roche S, Benistant C. ABL tyrosine kinase inhibition variable effects on the invasive properties of different triple negative breast cancer cell lines. Plos One. 10: e0118854. PMID 25803821 DOI: 10.1371/Journal.Pone.0118854  0.497
2015 Sirvent A, Urbach S, Roche S. Contribution of phosphoproteomics in understanding SRC signaling in normal and tumor cells. Proteomics. 15: 232-44. PMID 25403792 DOI: 10.1002/Pmic.201400162  0.539
2015 Fénié N, Bertrand C, Lacombe A, Roche S, Bousquet C, Gouazé-Andersson V, Toulas C, Moyal E, Ferrand A. Abstract B16: Progastrin activates colon fibroblasts and participates to the dialogue between tumor epithelial cells and stromal fibroblasts in colorectal cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Chtme14-B16  0.453
2015 Gioia R, Trégoat C, Dumas PY, Lagarde V, Prouzet-Mauléon V, Desplat V, Sirvent A, Praloran V, Lippert E, Villacreces A, Leconet W, Robert B, Vigon I, Roche S, Mahon FX, et al. CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-resistant chronic myeloid leukaemia Journal of Pathology. DOI: 10.1002/path.4561  0.301
2014 Najib S, Kowalski-Chauvel A, Do C, Roche S, Cohen-Jonathan-Moyal E, Seva C. Progastrin a new pro-angiogenic factor in colorectal cancer. Oncogene. 34: 3120-30. PMID 25109333 DOI: 10.1038/Onc.2014.255  0.415
2014 Sirvent A, Urbach S, Roche S. [Analysis of oncogenic signaling induced by tyrosine kinases in tumors by SILAC-based quantitative proteomic approach]. Medecine Sciences : M/S. 30: 558-66. PMID 24939544 DOI: 10.1051/Medsci/20143005020  0.517
2014 David M, Naudin C, Letourneur M, Polrot M, Renoir JM, Lazar V, Dessen P, Roche S, Bertoglio J, Pierre J. Suppressor of cytokine signaling 1 modulates invasion and metastatic potential of colorectal cancer cells. Molecular Oncology. 8: 942-55. PMID 24726456 DOI: 10.1016/J.Molonc.2014.03.014  0.72
2014 Naudin C, Sirvent A, Leroy C, Larive R, Simon V, Pannequin J, Bourgaux JF, Pierre J, Robert B, Hollande F, Roche S. SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2. Nature Communications. 5: 3159. PMID 24457997 DOI: 10.1038/Ncomms4159  0.848
2013 Tosti P, Leroy C, Simon V, Robert B, Pierre J, Sirvent A, Roche S. Abstract 2085: The antileukemic drug nilotinib inhibits the invasive activity and the metastatic potential of colorectal cancer cells by targeting the receptor tyrosine kinase DDR1. Cancer Research. 73: 2085-2085. DOI: 10.1158/1538-7445.Am2013-2085  0.823
2012 Sirvent A, Vigy O, Orsetti B, Urbach S, Roche S. Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts. Molecular & Cellular Proteomics : McP. 11: 1937-50. PMID 23023324 DOI: 10.1074/Mcp.M112.018168  0.521
2012 Fialin C, Larrue C, Vergez F, Sarry JE, Bertoli S, Mansat-De Mas V, Demur C, Delabesse E, Payrastre B, Manenti S, Roche S, Récher C. The short form of RON is expressed in acute myeloid leukemia and sensitizes leukemic cells to cMET inhibitors. Leukemia. 27: 325-35. PMID 22902361 DOI: 10.1038/Leu.2012.240  0.832
2012 Sirvent A, Benistant C, Roche S. Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer. American Journal of Cancer Research. 2: 357-71. PMID 22860228  0.436
2012 Tregoat C, Gioia R, Lagarde V, Prouzet-Mauleon V, Lippert E, Sirvent A, Roche S, Mahon F, Pasquet J. Cbl Controls the Expression of Axl and Lyn Tyrosine Kinases Mediating Resistance to Nilotinib in Chronic Myeloid Leukemia Cells Blood. 120: 3734-3734. DOI: 10.1182/Blood.V120.21.3734.3734  0.47
2012 Leroy C, Tosti P, Simon V, Robert B, Sirvent A, Roche S. Abstract 855: The antileukemia drug nilotinib inhibits invasion and metastasis of colorectal cancer cells by targeting the receptor tyrosine kinase DDR1 Cancer Research. 72: 855-855. DOI: 10.1158/1538-7445.Am2012-855  0.815
2012 Sirvent A, Urbach S, Roche S. Abstract 230: A novel quantitative phosphoproteomic approach in mouse xenograft models to identify Src oncogenic signaling in colorectal cancer Cancer Research. 72: 230-230. DOI: 10.1158/1538-7445.Am2012-230  0.521
2011 Gioia R, Leroy C, Drullion C, Lagarde V, Etienne G, Dulucq S, Lippert E, Roche S, Mahon FX, Pasquet JM. Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells Blood. 118: 2211-2221. PMID 21730355 DOI: 10.1182/Blood-2010-10-313692  0.804
2011 Sancier F, Dumont A, Sirvent A, Paquay de Plater L, Edmonds T, David G, Jan M, de Montrion C, Cogé F, Léonce S, Burbridge M, Bruno A, Boutin JA, Lockhart B, Roche S, et al. Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells. Plos One. 6: e17237. PMID 21390316 DOI: 10.1371/Journal.Pone.0017237  0.511
2011 Fialin C, Vergez F, Bertoli S, Mas VM, Demur C, Delabesse E, Payrastre B, Manenti S, Roche S, Récher C. Abstract 3130: The short form of the receptor tyrosine kinase Ron is expressed in acute myeloid leukemia, regulated by methylation and sensitizes leukemic cells to c-Met inhibitors Cancer Research. 71: 3130-3130. DOI: 10.1158/1538-7445.Am2011-3130  0.84
2011 Naudin C, Leroy C, Sirvent A, Simon V, Bourgaux J, Robert B, Pannequin J, Hollande F, Roche S. Abstract 1981: Tumor suppressor functions of the Src-like adaptor protein (SLAP) in colorectal cancer cells Cancer Research. 71: 1981-1981. DOI: 10.1158/1538-7445.Am2011-1981  0.842
2010 García-Martínez JM, Calcabrini A, González L, Martín-Forero E, Agulló-Ortuño MT, Simon V, Watkin H, Anderson SM, Roche S, Martín-Pérez J. A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling. Cellular Signalling. 22: 415-26. PMID 19892015 DOI: 10.1016/J.Cellsig.2009.10.013  0.575
2010 Gioia R, Leroy C, Drullion C, Lagarde V, Roche S, Mahon F, Pasquet j. Quantitative Phosphoproteomics Identified a New Syk-Lyn-Axl Signalling Pathway Involved In Resistance to Nilotinib In Chronic Myeloid Leukemia Cells. Blood. 116: 3376-3376. DOI: 10.1182/Blood.V116.21.3376.3376  0.788
2010 Leroy C, Robert B, Simon V, Roche S. 442 The Abl tyrosine kinase inhibitor Nilotinib inhibits invasive properties of colon cancer cells by targeting the discoidin domain receptor 1 European Journal of Cancer Supplements. 8: 113. DOI: 10.1016/S1359-6349(10)71243-X  0.791
2010 Naudin C, Leroy C, Sirvent A, Simon V, Bourgaux J, Robert B, Hollande F, Roche S. R37: Activité anti-oncogénique de la protéine de signalisation Src-Like Adaptor Protein dans les cancers colorectaux Bulletin Du Cancer. 97: S30. DOI: 10.1016/S0007-4551(15)30954-1  0.658
2010 Fialin C, Vergez F, Reutenauer S, Mansat-De Mas V, Demur C, Delabesse E, Payrastre B, Manenti S, Roche S, Récher C. R18: Expression, rôle et régulation épigénétique de la forme courte de Ron dans les leucémies aiguës myéloïdes (LAM) Bulletin Du Cancer. 97: S23. DOI: 10.1016/S0007-4551(15)30935-8  0.744
2009 Sirvent A, Bénistant C, Pannequin J, Veracini L, Simon V, Bourgaux JF, Hollande F, Cruzalegui F, Roche S. Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization. Oncogene. 29: 1303-15. PMID 20010872 DOI: 10.1038/Onc.2009.450  0.585
2009 Brignatz C, Paronetto MP, Opi S, Cappellari M, Audebert S, Feuillet V, Bismuth G, Roche S, Arold ST, Sette C, Collette Y. Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn. Molecular and Cellular Biology. 29: 6438-48. PMID 19805512 DOI: 10.1128/Mcb.00398-09  0.539
2009 Leroy C, Fialin C, Sirvent A, Simon V, Urbach S, Poncet J, Robert B, Jouin P, Roche S. Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells. Cancer Research. 69: 2279-86. PMID 19276381 DOI: 10.1158/0008-5472.Can-08-2354  0.841
2009 Fialin C, De Mas V, Manenti S, Payrastre B, Roche S, Recher C. The Receptor Tyrosine Kinase RON Is Constitutively Activated in Acute Myeloid Leukemia and May Represent a New Therapeutic Target. Blood. 114: 994-994. DOI: 10.1182/Blood.V114.22.994.994  0.848
2009 Pasquet J, Gioia R, Drullion C, Lagarde V, Leroy C, Roche S, Cardinaud B, Mahon F. Tyrosine Kinase Proteins profiling of Nilotinib Resistant Chronic Myelogenous Leukemia Cells Unravels a Tyrosine Kinase-Mediated Bypass. Blood. 114: 2175-2175. DOI: 10.1182/Blood.V114.22.2175.2175  0.81
2008 Mahon FX, Hayette S, Lagarde V, Belloc F, Turcq B, Nicolini F, Belanger C, Manley PW, Leroy C, Etienne G, Roche S, Pasquet JM. Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression. Cancer Research. 68: 9809-16. PMID 19047160 DOI: 10.1158/0008-5472.Can-08-1008  0.782
2008 Sirvent A, Benistant C, Roche S. Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells. Biology of the Cell. 100: 617-31. PMID 18851712 DOI: 10.1042/Bc20080020  0.537
2008 Veracini L, Simon V, Richard V, Schraven B, Horejsi V, Roche S, Benistant C. The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1. The Journal of Cell Biology. 182: 603-14. PMID 18695048 DOI: 10.1083/Jcb.200705102  0.52
2008 Sirvent A, Leroy C, Boureux A, Simon V, Roche S. The Src-like adaptor protein regulates PDGF-induced actin dorsal ruffles in a c-Cbl-dependent manner. Oncogene. 27: 3494-500. PMID 18193084 DOI: 10.1038/Sj.Onc.1211011  0.792
2008 Mahon Fe, Hayette S, Lagarde V, Nicolini FE, Belloc F, Leroy C, Roche S, Manley P, Belanger C, Etienne G, Pasquet J. Lyn Kinase Overexpression Is One of the Mechanisms of Resistance to Nilotinib In Chronic Myeloid Leukemia Blood. 112: 3181-3181. DOI: 10.1182/Blood.V112.11.3181.3181  0.777
2007 Collin G, Franco M, Simon V, Bénistant C, Roche S. The Tom1L1-clathrin heavy chain complex regulates membrane partitioning of the tyrosine kinase Src required for mitogenic and transforming activities. Molecular and Cellular Biology. 27: 7631-40. PMID 17785434 DOI: 10.1128/Mcb.00543-07  0.82
2007 Sirvent A, Boureux A, Simon V, Leroy C, Roche S. The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells. Oncogene. 26: 7313-23. PMID 17533370 DOI: 10.1038/Sj.Onc.1210543  0.817
2006 Veracini L, Franco M, Boureux A, Simon V, Roche S, Benistant C. Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles. Journal of Cell Science. 119: 2921-34. PMID 16787943 DOI: 10.1242/Jcs.03015  0.815
2006 Franco M, Furstoss O, Simon V, Benistant C, Hong WJ, Roche S. The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Molecular and Cellular Biology. 26: 1932-47. PMID 16479011 DOI: 10.1128/Mcb.26.5.1932-1947.2006  0.812
2005 Boureux A, Furstoss O, Simon V, Roche S. Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced by growth factors. Journal of Cell Science. 118: 3717-26. PMID 16076903 DOI: 10.1242/Jcs.02491  0.848
2005 Veracini L, Franco M, Boureux A, Simon V, Roche S, Benistant C. Two functionally distinct pools of Src kinases for PDGF receptor signalling Biochemical Society Transactions. 33: 1313-1315. DOI: 10.1042/Bst0331313  0.8
2004 Cussac D, Greenland C, Roche S, Bai RY, Duyster J, Morris SW, Delsol G, Allouche M, Payrastre B. Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity. Blood. 103: 1464-71. PMID 14563642 DOI: 10.1182/Blood-2003-04-1038  0.577
2003 Hollande F, Lee DJ, Choquet A, Roche S, Baldwin GS. Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells. Journal of Cell Science. 116: 1187-97. PMID 12615962 DOI: 10.1242/Jcs.00321  0.562
2003 Piiper A, Elez R, You SJ, Kronenberger B, Loitsch S, Roche S, Zeuzem S. Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor, Yes, and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon. The Journal of Biological Chemistry. 278: 7065-72. PMID 12496267 DOI: 10.1074/Jbc.M211234200  0.562
2002 Pandey A, Blagoev B, Kratchmarova I, Fernandez M, Nielsen M, Kristiansen TZ, Ohara O, Podtelejnikov AV, Roche S, Lodish HF, Mann M. Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. Oncogene. 21: 8029-36. PMID 12439753 DOI: 10.1038/Sj.Onc.1205988  0.511
2002 Furstoss O, Manes G, Roche S. Cyclin E and cyclin A are likely targets of Src for PDGF-induced DNA synthesis in fibroblasts. Febs Letters. 526: 82-6. PMID 12208509 DOI: 10.1016/S0014-5793(02)03120-4  0.812
2002 Yart A, Roche S, Wetzker R, Laffargue M, Tonks N, Mayeux P, Chap H, Raynal P. A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. The Journal of Biological Chemistry. 277: 21167-78. PMID 11916960 DOI: 10.1074/Jbc.M110411200  0.495
2002 Furstoss O, Dorey K, Simon V, Barilà D, Superti-Furga G, Roche S. c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis. The Embo Journal. 21: 514-24. PMID 11847100 DOI: 10.1093/Emboj/21.4.514  0.812
2001 Lara-Pezzi E, Roche S, Andrisani OM, Sánchez-Madrid F, López-Cabrera M. The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner Oncogene. 20: 3323-3331. PMID 11423982 DOI: 10.1038/Sj.Onc.1204451  0.422
2001 Bony C, Roche S, Shuichi U, Sasaki T, Crackower MA, Penninger J, Mano H, Pucéat M. A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. The Journal of Cell Biology. 152: 717-28. PMID 11266463 DOI: 10.1083/Jcb.152.4.717  0.496
2001 Yart A, Laffargue M, Mayeux P, Chretien S, Peres C, Tonks N, Roche S, Payrastre B, Chap H, Raynal P. A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor Journal of Biological Chemistry. 276: 8856-8864. PMID 11134009 DOI: 10.1074/Jbc.M006966200  0.538
2000 Bénistant C, Chapuis H, Roche S. A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. Oncogene. 19: 5083-90. PMID 11042696 DOI: 10.1038/Sj.Onc.1203871  0.486
2000 Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF. Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. The Journal of Biological Chemistry. 275: 38633-9. PMID 10993906 DOI: 10.1074/Jbc.M007849200  0.511
2000 Bénistant C, Chapuis H, Mottet N, Noletti J, Crapez E, Bali JP, Roche S. Deregulation of the cytoplasmic tyrosine kinase cSrc in the absence of a truncating mutation at codon 531 in human bladder carcinoma. Biochemical and Biophysical Research Communications. 273: 425-30. PMID 10873622 DOI: 10.1006/Bbrc.2000.2948  0.534
2000 Manes G, Bello P, Roche S. Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes. Molecular and Cellular Biology. 20: 3396-406. PMID 10779329 DOI: 10.1128/Mcb.20.10.3396-3406.2000  0.532
2000 Laffargue M, Raynal P, Yart A, Peres C, Wetzker R, Roche S, Payrastre B, Chap H. An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid. The Journal of Biological Chemistry. 274: 32835-41. PMID 10551845 DOI: 10.1074/Jbc.274.46.32835  0.563
2000 Desai A, Holleran EA, Roche S, Servant G, Weiner O, Aasland R, Weinzierl RO, Ponnambalam V, Slesinger PA, Pfaff M, Schuldt A, Kudoh T, Sclafani RA. Cell biology Current Opinion in Cell Biology. 12: 265-275. DOI: 10.1016/S0955-0674(00)00086-7  0.326
1999 DESAI A, HOLLERAN E, ROCHE S, AASLAND R, WEINZIERL R, IZAURRALDE E, MATTER K, SLESINGER P, PFAFF M, HUCKRIEDE N. Cell biologyPaper alert Current Opinion in Cell Biology. 11: 641-650. DOI: 10.1016/S0955-0674(99)00048-4  0.329
1998 Roche S, Downward J, Raynal P, Courtneidge SA. A function for phosphatidylinositol 3-kinase β (p85α-p110β) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction Molecular and Cellular Biology. 18: 7119-7129. PMID 9819398 DOI: 10.1128/Mcb.18.12.7119  0.544
1998 Roche S, Alonso G, Kazlauskas A, Dixit VM, Courtneidge SA, Pandey A. Src-like adaptor protein (Slap) is a negative regulator of mitogenesis. Current Biology : Cb. 8: 975-8. PMID 9742401 DOI: 10.1016/S0960-9822(98)70400-2  0.516
1998 Pucéat M, Roche S, Vassort G. Src family tyrosine kinase regulates intracellular pH in cardiomyocytes. The Journal of Cell Biology. 141: 1637-46. PMID 9647655 DOI: 10.1083/Jcb.141.7.1637  0.547
1997 Boyer B, Roche S, Denoyelle M, Thiery JP. Src and Ras are involved in separate pathways in epithelial cell scattering The Embo Journal. 16: 5904-5913. PMID 9312048 DOI: 10.1093/Emboj/16.19.5904  0.512
1997 Carroll DJ, Ramarao CS, Mehlmann LM, Roche S, Terasaki M, Jaffe LA. Calcium release at fertilization in starfish eggs is mediated by phospholipase Cgamma. The Journal of Cell Biology. 138: 1303-11. PMID 9298985 DOI: 10.1083/Jcb.138.6.1303  0.327
1997 Chedin M, Filhol O, Duminy C, Bolla M, Benistant C, Roche S, Chambaz EM, Cochet C. Characterization of two different cytoplasmic protein tyrosine kinases from human breast cancer. Carcinogenesis. 18: 1463-72. PMID 9276617 DOI: 10.1093/Carcin/18.8.1463  0.517
1996 Erpel T, Alonso G, Roche S, Courtneidge SA. The Src SH3 domain is required for DNA synthesis induced by platelet-derived growth factor and epidermal growth factor. The Journal of Biological Chemistry. 271: 16807-12. PMID 8663328 DOI: 10.1074/Jbc.271.28.16807  0.5
1996 Roche S, McGlade J, Jones M, Gish GD, Pawson T, Courtneidge SA. Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways. The Embo Journal. 15: 4940-4948. DOI: 10.1002/J.1460-2075.1996.Tb00874.X  0.474
1995 Dornand J, Roche S, Michel F, Bali JP, Cabane S, Favero J, Magous R. Gastrin-CCK-B type receptors on human T lymphoblastoid Jurkat cells. The American Journal of Physiology. 268: G522-9. PMID 7900813 DOI: 10.1152/Ajpgi.1995.268.3.G522  0.301
1995 Roche S, Koegl M, Barone MV, Roussel MF, Courtneidge SA. DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases Molecular and Cellular Biology. 15: 1102-1109. PMID 7823926 DOI: 10.1128/Mcb.15.2.1102  0.559
1995 Roche S, Fumagalli S, Courtneidge SA. Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division Science. 269: 1567-1569. PMID 7545311 DOI: 10.1126/Science.7545311  0.522
1994 Roche S, Koegl M, Courtneidge SA. The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors Proceedings of the National Academy of Sciences of the United States of America. 91: 9185-9189. PMID 8090789 DOI: 10.1073/Pnas.91.19.9185  0.43
1994 Roche S, Dhand R, Waterfield MD, Courtneidge SA. The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen pp60(c-src) complexes Biochemical Journal. 301: 703-711. PMID 7519847 DOI: 10.1042/Bj3010703  0.48
1994 Dhand R, Hiles I, Panayotou G, Roche S, Fry M, Gout I, Totty N, Truong O, Vicendo P, Yonezawa K. PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. The Embo Journal. 13: 522-533. DOI: 10.1002/J.1460-2075.1994.Tb06290.X  0.481
1992 Roche S, Gusdinar T, Bali JP, Magous R. Relationship between inositol 1,4,5-trisphosphate mass level and [14C]aminopyrine uptake in gastrin-stimulated parietal cells. Molecular and Cellular Endocrinology. 77: 109-13. PMID 1815995 DOI: 10.1016/0303-7207(91)90064-Y  0.307
1991 Roche S, Bali JP, Magous R. Involvement of a pertussis toxin-sensitive G protein in the action of gastrin on gastric parietal cells. Biochimica Et Biophysica Acta. 1055: 287-94. PMID 2124930 DOI: 10.1016/0167-4889(90)90045-F  0.323
1991 Roche S, Bali JP, Galleyrand JC, Magous R. Characterization of a gastrin-type receptor on rabbit gastric parietal cells using L365,260 and L364,718. The American Journal of Physiology. 260: G182-8. PMID 1996638 DOI: 10.1152/Ajpgi.1991.260.2.G182  0.313
1991 Roche S, Gusdinar T, Bali J, Magous R. "Gastrin" and "CCK" receptors on histamine- and somatostatin-containing cells from rabbit fundic mucosa--I. Characterization by means of agonists. Biochemical Pharmacology. 42: 765-770. PMID 1714275 DOI: 10.1016/0006-2952(91)90034-3  0.306
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