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Joshua A. Kritzer, Ph.D. - Publications

Affiliations: 
Chemistry Tufts University, Boston 
Area:
Bioorganic chemistry, Biophysical chemistry, Chemical Biology
Website:
https://chem.tufts.edu/people/faculty/joshua-kritzer
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Huh S, Batistatou N, Wang J, Saunders GJ, Kritzer JA, Yudin AK. Cell penetration of oxadiazole-containing macrocycles. Rsc Chemical Biology. 5: 328-334. PMID 38576720 DOI: 10.1039/d3cb00201b  0.42
2023 Fonseca Lopez F, Miao J, Damjanovic J, Bischof L, Braun MB, Ling Y, Hartmann MD, Lin YS, Kritzer JA. Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders. Journal of Chemical Information and Modeling. PMID 37917529 DOI: 10.1021/acs.jcim.3c01337  0.417
2023 Kavoosi S, Deprey K, Kritzer JA, Islam K. 5-Dihydroxyboryluridine enhances cytosolic penetration of antisense oligonucleotides. Chemical Communications (Cambridge, England). PMID 37345964 DOI: 10.1039/d3cc01945d  0.774
2022 Brown H, Chung M, Üffing A, Batistatou N, Tsang T, Doskocil S, Mao W, Willbold D, Bast RC, Lu Z, Weiergräber OH, Kritzer JA. Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy. Journal of the American Chemical Society. 144: 14687-14697. PMID 35917476 DOI: 10.1021/jacs.2c04699  0.443
2022 Deprey K, Batistatou N, Debets MF, Godfrey J, VanderWall KB, Miles RR, Shehaj L, Guo J, Andreucci A, Kandasamy P, Lu G, Shimizu M, Vargeese C, Kritzer JA. Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics. Acs Chemical Biology. PMID 35034446 DOI: 10.1021/acschembio.1c00830  0.786
2021 Pace JR, Lampkin BJ, Abakah C, Moyer A, Miao J, Deprey K, Cerulli RA, Lin YS, Baleja JD, Baker D, Kritzer JA. Stapled β-Hairpins Featuring 4-Mercaptoproline. Journal of the American Chemical Society. PMID 34516087 DOI: 10.1021/jacs.1c04378  0.793
2021 Mientkiewicz KM, Peraro L, Kritzer JA. Parallel Screening Using the Chloroalkane Penetration Assay Reveals Structure-Penetration Relationships. Acs Chemical Biology. 16: 1184-1190. PMID 34224243 DOI: 10.1021/acschembio.1c00434  0.797
2021 Gray JP, Uddin MN, Chaudhari R, Sutton MN, Yang H, Rask P, Locke H, Engel BJ, Batistatou N, Wang J, Grindel BJ, Bhattacharya P, Gammon ST, Zhang S, Piwnica-Worms D, ... Kritzer JA, et al. Directed evolution of cyclic peptides for inhibition of autophagy. Chemical Science. 12: 3526-3543. PMID 34163626 DOI: 10.1039/d0sc03603j  0.453
2021 Deprey K, Kritzer JA. HaloTag Forms an Intramolecular Disulfide. Bioconjugate Chemistry. PMID 33856762 DOI: 10.1021/acs.bioconjchem.1c00113  0.787
2020 Gallagher EE, Menon A, Chmiel AF, Deprey K, Kritzer JA, Garner AL. A cell-penetrant lactam-stapled peptide for targeting eIF4E protein-protein interactions. European Journal of Medicinal Chemistry. 205: 112655. PMID 32739551 DOI: 10.1016/J.Ejmech.2020.112655  0.825
2020 Deprey K, Kritzer JA. Quantitative measurement of cytosolic penetration using the chloroalkane penetration assay. Methods in Enzymology. 641: 277-309. PMID 32713526 DOI: 10.1016/Bs.Mie.2020.03.003  0.809
2020 Deprey K, Batistatou N, Kritzer JA. A critical analysis of methods used to investigate the cellular uptake and subcellular localization of RNA therapeutics. Nucleic Acids Research. PMID 32644123 DOI: 10.1093/Nar/Gkaa576  0.771
2020 Cerulli RA, Shehaj L, Tosic I, Jiang K, Wang J, Frank DA, Kritzer JA. Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors. Bioorganic & Medicinal Chemistry. 28: 115542. PMID 32503696 DOI: 10.1016/J.Bmc.2020.115542  0.849
2020 Cerulli RA, Shehaj L, Brown HF, Pace JR, Mei Y, Kritzer JA. Stapled peptide inhibitors of autophagy adapter LC3B. Chembiochem : a European Journal of Chemical Biology. PMID 32406996 DOI: 10.1002/Cbic.202000212  0.824
2020 Yin H, Huang YH, Deprey K, Condon ND, Kritzer JA, Craik DJ, Wang CK. Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold. Acs Chemical Biology. PMID 32315152 DOI: 10.1021/Acschembio.0C00297  0.83
2019 Cerulli RA, Kritzer JA. Phosphotyrosine isosteres: past, present and future. Organic & Biomolecular Chemistry. PMID 31777907 DOI: 10.1039/C9Ob01998G  0.82
2019 Shehaj L, Choudary S, Makwana K, Gallo M, Murphy TF, Kritzer JA. Small-molecule inhibitors of Haemophilus influenzae IgA1 protease. Acs Infectious Diseases. PMID 31016966 DOI: 10.1021/Acsinfecdis.9B00004  0.775
2019 Cerulli RA, Kritzer JA. Stringing Together a Universal Influenza Antibody. Biochemistry. 58: 1943-1944. PMID 30946571 DOI: 10.1021/Acs.Biochem.9B00002  0.737
2019 Deprey K, Becker L, Kritzer JA, Plückthun A. Trapped! A critical evaluation of methods for measuring total cellular uptake versus cytosolic localization. Bioconjugate Chemistry. PMID 30882208 DOI: 10.1021/Acs.Bioconjchem.9B00112  0.767
2019 Cummings AE, Miao J, Slough DP, McHugh SM, Kritzer JA, Lin YS. β-Branched Amino Acids Stabilize Specific Conformations of Cyclic Hexapeptides. Biophysical Journal. PMID 30661666 DOI: 10.1016/J.Bpj.2018.12.015  0.414
2018 Peraro L, Deprey KL, Moser MK, Zou Z, Ball HL, Levine B, Kritzer JA. Cell Penetration Profiling Using the Chloroalkane Penetration Assay. Journal of the American Chemical Society. PMID 30118219 DOI: 10.1021/Jacs.8B06144  0.804
2018 Peraro L, Kritzer JA. Emerging Methods and Design Principles for Cell-Penetrant Peptides. Angewandte Chemie (International Ed. in English). PMID 29740917 DOI: 10.1002/Anie.201801361  0.84
2018 Slough DP, McHugh SM, Cummings AE, Dai P, Pentelute BL, Kritzer JA, Lin YS. Designing Well-Structured Cyclic Pentapeptides Based on Sequence-Structure Relationships. The Journal of Physical Chemistry. B. PMID 29589926 DOI: 10.1021/Acs.Jpcb.8B01747  0.473
2018 Kritzer JA, Freyzon Y, Lindquist S. Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway. Fems Yeast Research. PMID 29546391 DOI: 10.1093/Femsyr/Foy027  0.548
2018 Peraro L, Kritzer JA. Neue Methoden und Designprinzipien für zellgängige Peptide Angewandte Chemie. 130: 12042-12057. DOI: 10.1002/Ange.201801361  0.487
2017 Kamens AJ, Mientkiewicz KM, Eisert RJ, Walz JA, Mace CR, Kritzer JA. Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1. Bioorganic & Medicinal Chemistry. PMID 28951093 DOI: 10.1016/J.Bmc.2017.09.007  0.773
2017 Peraro L, Zou Z, Makwana KM, Cummings A, Ball HL, Yu H, Lin YS, Levine B, Kritzer JA. Diversity-oriented stapling yields intrinsically cell-penetrant inducers of autophagy. Journal of the American Chemical Society. PMID 28414223 DOI: 10.1021/Jacs.7B01698  0.815
2017 Siegert TR, Bird M, Kritzer JA. Identifying Loop-Mediated Protein-Protein Interactions Using LoopFinder. Methods in Molecular Biology (Clifton, N.J.). 1561: 255-277. PMID 28236243 DOI: 10.1007/978-1-4939-6798-8_15  0.497
2016 Kritzer JA. Stapled peptides: How to be quick on the uptake. Nature Chemical Biology. 12: 764-765. PMID 27649052 DOI: 10.1038/Nchembio.2183  0.473
2016 Siegert TR, Bird MJ, Makwana KM, Kritzer JA. Analysis of Loops that Mediate Protein-Protein Interactions and Translation into Sub-Micromolar Inhibitors. Journal of the American Chemical Society. PMID 27611902 DOI: 10.1021/Jacs.6B05656  0.808
2016 Peraro L, Siegert TR, Kritzer JA. Conformational Restriction of Peptides Using Dithiol Bis-Alkylation. Methods in Enzymology. 580: 303-32. PMID 27586339 DOI: 10.1016/Bs.Mie.2016.05.035  0.539
2014 Quartararo JS, Eshelman MR, Peraro L, Yu H, Baleja JD, Lin YS, Kritzer JA. A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake. Bioorganic & Medicinal Chemistry. 22: 6387-91. PMID 25438762 DOI: 10.1016/J.Bmc.2014.09.050  0.819
2014 Eshelman MR, Aldous AR, Neupane KP, Kritzer JA. Solution structure of a designed cyclic peptide ligand for nickel and copper ions. Tetrahedron. 70: 7651-7654. PMID 25414527 DOI: 10.1016/J.Tet.2014.07.083  0.805
2014 Gavenonis J, Sheneman BA, Siegert TR, Eshelman MR, Kritzer JA. Comprehensive analysis of loops at protein-protein interfaces for macrocycle design. Nature Chemical Biology. 10: 716-22. PMID 25038791 DOI: 10.1038/Nchembio.1580  0.815
2014 Kamens AJ, Eisert RJ, Corlin T, Baleja JD, Kritzer JA. Structured cyclic peptides that bind the EH domain of EHD1. Biochemistry. 53: 4758-60. PMID 25014215 DOI: 10.1021/Bi500744Q  0.81
2014 Gavenonis J, Jonas NE, Kritzer JA. Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix. Bioorganic & Medicinal Chemistry. 22: 3989-93. PMID 24984936 DOI: 10.1016/J.Bmc.2014.06.006  0.813
2014 Neupane KP, Aldous AR, Kritzer JA. Metal-binding and redox properties of substituted linear and cyclic ATCUN motifs. Journal of Inorganic Biochemistry. 139: 65-76. PMID 24980953 DOI: 10.1016/J.Jinorgbio.2014.06.004  0.785
2013 Choudary SK, Qiu J, Plaut AG, Kritzer JA. Versatile substrates and probes for IgA1 protease activity. Chembiochem : a European Journal of Chemical Biology. 14: 2007-12. PMID 24038810 DOI: 10.1002/Cbic.201300281  0.803
2013 Neupane KP, Aldous AR, Kritzer JA. Macrocyclization of the ATCUN motif controls metal binding and catalysis. Inorganic Chemistry. 52: 2729-35. PMID 23421754 DOI: 10.1021/Ic302820Z  0.762
2013 Bock JE, Gavenonis J, Kritzer JA. Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints. Acs Chemical Biology. 8: 488-99. PMID 23170954 DOI: 10.1021/Cb300515U  0.833
2012 Kritzer JA. The secret of MIM: a novel, MCL-1-specific small molecule. Chemistry & Biology. 19: 1082-3. PMID 22999875 DOI: 10.1016/J.Chembiol.2012.08.016  0.408
2012 Quartararo JS, Wu P, Kritzer JA. Peptide bicycles that inhibit the Grb2 SH2 domain. Chembiochem : a European Journal of Chemical Biology. 13: 1490-6. PMID 22689355 DOI: 10.1002/Cbic.201200175  0.846
2012 Quartararo JS, Wu P, Kritzer JA. Inside Cover: Peptide Bicycles that Inhibit the Grb2 SH2 Domain (ChemBioChem 10/2012) Chembiochem. 13: 1378-1378. DOI: 10.1002/Cbic.201290039  0.824
2010 Kritzer JA. Stapled peptides: Magic bullets in nature's arsenal. Nature Chemical Biology. 6: 566-7. PMID 20644540 DOI: 10.1038/Nchembio.407  0.496
2010 Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, et al. Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Disease Models & Mechanisms. 3: 194-208. PMID 20038714 DOI: 10.1242/Dmm.004267  0.756
2009 Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S. Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nature Chemical Biology. 5: 655-63. PMID 19597508 DOI: 10.1038/Nchembio.193  0.641
2006 Zellefrow CD, Griffiths JS, Saha S, Hodges AM, Goodman JL, Paulk J, Kritzer JA, Schepartz A. Encodable activators of SRC family kinases. Journal of the American Chemical Society. 128: 16506-7. PMID 17177392 DOI: 10.1021/Ja0672977  0.79
2006 Kritzer JA, Zutshi R, Cheah M, Ran FA, Webman R, Wongjirad TM, Schepartz A. Miniature protein inhibitors of the p53-hDM2 interaction. Chembiochem : a European Journal of Chemical Biology. 7: 29-31. PMID 16397877 DOI: 10.1002/Cbic.200500324  0.674
2005 Kritzer JA, Luedtke NW, Harker EA, Schepartz A. A rapid library screen for tailoring beta-peptide structure and function. Journal of the American Chemical Society. 127: 14584-5. PMID 16231906 DOI: 10.1021/Ja055050O  0.801
2005 Kritzer JA, Hodsdon ME, Schepartz A. Solution structure of a beta-peptide ligand for hDM2. Journal of the American Chemical Society. 127: 4118-9. PMID 15783163 DOI: 10.1021/Ja042933R  0.611
2005 Kritzer JA, Tirado-Rives J, Hart SA, Lear JD, Jorgensen WL, Schepartz A. Relationship between side chain structure and 14-helix stability of beta3-peptides in water. Journal of the American Chemical Society. 127: 167-78. PMID 15631466 DOI: 10.1021/Ja0459375  0.724
2005 Kritzer JA, Stephens OM, Guarracino DA, Reznik SK, Schepartz A. beta-Peptides as inhibitors of protein-protein interactions. Bioorganic & Medicinal Chemistry. 13: 11-6. PMID 15582447 DOI: 10.1016/J.Bmc.2004.09.009  0.832
2005 Kritzer JA, Stephens OM, Guarracino DA, Reznik SK, Schepartz A. ?-Peptides as Inhibitors of Protein?Protein Interactions Cheminform. 36. DOI: 10.1002/chin.200513287  0.822
2004 Kritzer JA, Lear JD, Hodsdon ME, Schepartz A. Helical beta-peptide inhibitors of the p53-hDM2 interaction. Journal of the American Chemical Society. 126: 9468-9. PMID 15291512 DOI: 10.1021/Ja031625A  0.632
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