Nicolas Jonckheere - Publications

Affiliations: 
Lille 2 

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Quilbe A, Mustapha R, Duchêne B, Kumar A, Werkmeister E, Leteurtre E, Moralès O, Jonckheere N, Van Seuningen I, Delhem N. A novel anti-galectin-9 immunotherapy limits the early progression of pancreatic neoplastic lesions in transgenic mice. Frontiers in Immunology. 14: 1267279. PMID 38098486 DOI: 10.3389/fimmu.2023.1267279  0.596
2023 Jannin A, Dessein AF, Do Cao C, Vantyghem MC, Chevalier B, Van Seuningen I, Jonckheere N, Coppin L. Metabolism of pancreatic neuroendocrine tumors: what can omics tell us? Frontiers in Endocrinology. 14: 1248575. PMID 37908747 DOI: 10.3389/fendo.2023.1248575  0.565
2022 Auwercx J, Kischel P, Lefebvre T, Jonckheere N, Vanlaeys A, Guénin S, Radoslavova S, Van Seuningen I, Ouadid-Ahidouch H, Kocher HM, Dhennin-Duthille I, Gautier M. TRPM7 Modulates Human Pancreatic Stellate Cell Activation. Cells. 11. PMID 35883700 DOI: 10.3390/cells11142255  0.692
2022 Foulon A, Rybarczyk P, Jonckheere N, Brabencova E, Sevestre H, Ouadid-Ahidouch H, Rodat-Despoix L. Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool? International Journal of Molecular Sciences. 23. PMID 35328381 DOI: 10.3390/ijms23062962  0.306
2022 Raab S, Very N, Duchêne B, Rybarczyk P, Jonckheere N, El Yazidi-Belkoura I, Lefebvre T. Evaluation of the expression of fatty acid synthase and -GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches. Oncology Letters. 23: 105. PMID 35242233 DOI: 10.3892/ol.2022.13225  0.373
2021 Boukrout N, Souidi M, Lahdaoui F, Duchêne B, Neve B, Coppin L, Leteurtre E, Torrisani J, Van Seuningen I, Jonckheere N. Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma. Cancers. 13. PMID 34944818 DOI: 10.3390/cancers13246197  0.819
2021 Stoup N, Liberelle M, Schulz C, Cavdarli S, Vasseur R, Magnez R, Lahdaoui F, Skrypek N, Peretti F, Frénois F, Thuru X, Melnyk P, Renault N, Jonckheere N, Lebègue N, et al. The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis. Cancers. 13. PMID 34830899 DOI: 10.3390/cancers13225746  0.796
2021 Hadj Bachir E, Poiraud C, Paget S, Stoup N, El Moghrabi S, Duchêne B, Jouy N, Bongiovanni A, Tardivel M, Weiswald LB, Vandepeutte M, Beugniez C, Escande F, Leteurtre E, ... ... Jonckheere N, et al. A new pancreatic adenocarcinoma-derived organoid model of acquired chemoresistance to FOLFIRINOX: First insight of the underlying mechanisms. Biology of the Cell. PMID 34561874 DOI: 10.1111/boc.202100003  0.747
2021 Jonckheere N, Vincent A, Neve B, Van Seuningen I. Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers. Biochimica Et Biophysica Acta. Reviews On Cancer. 188538. PMID 33862149 DOI: 10.1016/j.bbcan.2021.188538  0.801
2021 Auwercx J, Rybarczyk P, Kischel P, Dhennin-Duthille I, Chatelain D, Sevestre H, Van Seuningen I, Ouadid-Ahidouch H, Jonckheere N, Gautier M. Mg Transporters in Digestive Cancers. Nutrients. 13. PMID 33450887 DOI: 10.3390/nu13010210  0.617
2020 Jonckheere N, Auwercx J, Hadj Bachir E, Coppin L, Boukrout N, Vincent A, Neve B, Gautier M, Treviño V, Van Seuningen I. Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival. Cancers. 12. PMID 33182511 DOI: 10.3390/cancers12113309  0.747
2020 Neve B, Jonckheere N, Vincent A, Van Seuningen I. Long non-coding RNAs: the tentacles of chromatin remodeler complexes. Cellular and Molecular Life Sciences : Cmls. PMID 33001247 DOI: 10.1007/s00018-020-03646-0  0.714
2020 Liberelle M, Jonckheere N, Melnyk P, Van Seuningen I, Lebègue N. EGF-Containing Membrane-Bound Mucins: A Hidden ErbB2 Targeting Pathway? Journal of Medicinal Chemistry. PMID 32027502 DOI: 10.1021/Acs.Jmedchem.9B02001  0.646
2019 Jonckheere N, Van Seuningen I. Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required. Annals of Translational Medicine. 7: S43. PMID 31032322 DOI: 10.21037/Atm.2019.03.01  0.682
2018 Neve B, Jonckheere N, Vincent A, Van Seuningen I. Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer. Cancers. 10. PMID 30441811 DOI: 10.3390/Cancers10110440  0.815
2018 Jonckheere N, Van Seuningen I. Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas. Journal of Translational Medicine. 16: 259. PMID 30236127 DOI: 10.1186/S12967-018-1632-2  0.66
2018 Drubay V, Skrypek N, Cordiez L, Vasseur R, Schulz C, Boukrout N, Duchêne B, Coppin L, Van Seuningen I, Jonckheere N. TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727. Cancers. 10. PMID 30065235 DOI: 10.3390/Cancers10080254  0.821
2017 Lahdaoui F, Messager M, Vincent A, Hec F, Gandon A, Warlaumont M, Renaud F, Leteurtre E, Piessen G, Jonckheere N, Mariette C, Van Seuningen I. Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: Implication of the Wnt/β-catenin pathway. The Biochemical Journal. PMID 28972071 DOI: 10.1042/Bcj20170348  0.831
2017 Jonckheere N, Vasseur R, Van Seuningen I. The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting. Critical Reviews in Oncology/Hematology. 111: 7-19. PMID 28259298 DOI: 10.1016/J.Critrevonc.2017.01.002  0.619
2017 Porte R, Van Maele L, Muñoz-Wolf N, Foligné B, Dumoutier L, Tabareau J, Cayet D, Gosset P, Jonckheere N, Van Seuningen I, Chabalgoity JA, Simonet M, Lamkanfi M, Renauld JC, Sirard JC, et al. Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22. Infection and Immunity. 85. PMID 27872237 DOI: 10.1128/Iai.00806-16  0.577
2016 Skrypek N, Boukrout N, Lahdaoui F, Schulz C, Vasseur R, Duchêne B, Seuningen IV, Jonckheere N. Abstract B31: The MUC4 oncomucin mediates resistance of human pancreatic cancer cells to FOLFIRINOX drugs Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B31  0.795
2015 Jonckheere N, Lahdaoui F, Van Seuningen I. Targeting MUC4 in pancreatic cancer: miRNAs. Oncoscience. 2: 799-800. PMID 26682251 DOI: 10.18632/oncoscience.249  0.789
2015 Vasseur R, Skrypek N, Duchêne B, Renaud F, Martínez-Maqueda D, Vincent A, Porchet N, Van Seuningen I, Jonckheere N. The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways. Biochimica Et Biophysica Acta. 1849: 1375-1384. PMID 26477488 DOI: 10.1016/J.Bbagrm.2015.10.014  0.802
2015 Tréhoux S, Lahdaoui F, Delpu Y, Renaud F, Leteurtre E, Torrisani J, Jonckheere N, Van Seuningen I. Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. Biochimica Et Biophysica Acta. 1853: 2392-403. PMID 26036346 DOI: 10.1016/J.Bbamcr.2015.05.033  0.758
2015 Skrypek N, Vasseur R, Vincent A, Duchêne B, Van Seuningen I, Jonckheere N. The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2. Oncotarget. 6: 10853-67. PMID 25890497 DOI: 10.18632/Oncotarget.3414  0.819
2015 Vincent A, Kazmierczak C, Duchêne B, Jonckheere N, Leteurtre E, Van Seuningen I. Cryosectioning the intestinal crypt-villus axis: an ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells. Stem Cell Research. 14: 105-13. PMID 25590428 DOI: 10.1016/J.Scr.2014.12.002  0.756
2015 Desurmont T, Skrypek N, Duhamel A, Jonckheere N, Millet G, Leteurtre E, Gosset P, Duchene B, Ramdane N, Hebbar M, Van Seuningen I, Pruvot FR, Huet G, Truant S. Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival. Cancer Science. 106: 262-9. PMID 25580640 DOI: 10.1111/Cas.12603  0.803
2015 Tréhoux S, Duchêne B, Jonckheere N, Van Seuningen I. The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways. Biochemical and Biophysical Research Communications. 456: 757-62. PMID 25511698 DOI: 10.1016/J.Bbrc.2014.12.025  0.815
2015 Lahdaoui F, Delpu Y, Vincent A, Renaud F, Messager M, Duchêne B, Leteurtre E, Mariette C, Torrisani J, Jonckheere N, Van Seuningen I. miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer. Oncogene. 34: 780-8. PMID 24608432 DOI: 10.1038/Onc.2014.11  0.823
2014 Gronnier C, Bruyère E, Lahdaoui F, Jonckheere N, Perrais M, Leteurtre E, Piessen G, Mariette C, Van Seuningen I. The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells. Biochimica Et Biophysica Acta. 1843: 2432-7. PMID 25003315 DOI: 10.1016/J.Bbamcr.2014.06.021  0.809
2014 Jonckheere N, Vincent A, Van Seuningen I. Of autophagy and in vivo pancreatic carcinogenesis: the p53 status matters! Clinics and Research in Hepatology and Gastroenterology. 38: 423-5. PMID 24939064 DOI: 10.1016/J.Clinre.2014.04.009  0.785
2014 Jonckheere N, Skrypek N, Van Seuningen I. Mucins and tumor resistance to chemotherapeutic drugs. Biochimica Et Biophysica Acta. 1846: 142-51. PMID 24785432 DOI: 10.1016/J.Bbcan.2014.04.008  0.825
2014 Jonckheere N, Van Seuningen I. Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 35: 3941-2. PMID 24241961 DOI: 10.1007/S13277-013-1390-Y  0.628
2014 Perrais M, Rousseaux C, Ducourouble MP, Courcol R, Vincent P, Jonckheere N, Van Seuningen I. Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells. Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 17: 235-46. PMID 23703470 DOI: 10.1007/S10120-013-0267-5  0.642
2013 Jonckheere N, Skrypek N, Frénois F, Van Seuningen I. Membrane-bound mucin modular domains: from structure to function. Biochimie. 95: 1077-86. PMID 23178705 DOI: 10.1016/J.Biochi.2012.11.005  0.764
2012 Skrypek N, Duchêne B, Hebbar M, Leteurtre E, van Seuningen I, Jonckheere N. The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family. Oncogene. 32: 1714-23. PMID 22580602 DOI: 10.1038/Onc.2012.179  0.813
2012 Jonckheere N, Vincent A, Franquet-Ansart H, Witte-Bouma J, Korteland-van Male A, Leteurtre E, Renes IB, Van Seuningen I. GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells. Biochimica Et Biophysica Acta. 1819: 869-76. PMID 22554936 DOI: 10.1016/J.Bbagrm.2012.04.003  0.787
2012 Vincent DF, Gout J, Chuvin N, Arfi V, Pommier RM, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard-Léon S, Colombe A, Janier M, Van Seuningen I, et al. Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway. The American Journal of Pathology. 180: 2214-21. PMID 22469842 DOI: 10.1016/J.Ajpath.2012.02.006  0.673
2012 Jonckheere N, Skrypek N, Merlin J, Dessein AF, Dumont P, Leteurtre E, Harris A, Desseyn JL, Susini C, Frénois F, Van Seuningen I. The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. Plos One. 7: e32232. PMID 22393391 DOI: 10.1371/Journal.Pone.0032232  0.838
2011 Bruyère E, Jonckheere N, Frénois F, Mariette C, Van Seuningen I. The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein. Biochemical and Biophysical Research Communications. 413: 325-9. PMID 21889495 DOI: 10.1016/J.Bbrc.2011.08.095  0.837
2011 Jonckheere N, Velghe A, Ducourouble MP, Copin MC, Renes IB, Van Seuningen I. The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors. The Febs Journal. 278: 282-94. PMID 21126317 DOI: 10.1111/J.1742-4658.2010.07945.X  0.609
2010 Jonckheere N, Skrypek N, Van Seuningen I. Mucins and pancreatic cancer. Cancers. 2: 1794-812. PMID 24281201 DOI: 10.3390/Cancers2041794  0.842
2010 Dessein AF, Stechly L, Jonckheere N, Dumont P, Monté D, Leteurtre E, Truant S, Pruvot FR, Figeac M, Hebbar M, Lecellier CH, Lesuffleur T, Dessein R, Grard G, Dejonghe MJ, et al. Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells. Cancer Research. 70: 4644-54. PMID 20460542 DOI: 10.1158/0008-5472.Can-09-3828  0.467
2010 Jonckheere N, Van Seuningen I. The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers. Biochimie. 92: 1-11. PMID 19818375 DOI: 10.1016/J.Biochi.2009.09.018  0.737
2009 Jonckheere N, Fauquette V, Stechly L, Saint-Laurent N, Aubert S, Susini C, Huet G, Porchet N, Van Seuningen I, Pigny P. Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression. British Journal of Cancer. 101: 637-44. PMID 19672266 DOI: 10.1038/Sj.Bjc.6605190  0.637
2009 Jonckheere N, Skrypek N, Saint-Laurent N, Susini C, VAN SEUNINGEN I. T1998 The Muc4 Membrane-Bound Mucin Alters In Vitro and In Vivo Biological Properties of Human Pancreatic Cancer Cells Gastroenterology. 136: A-617. DOI: 10.1016/S0016-5085(09)62844-4  0.805
2008 Jonckheere N, Van Seuningen I. The membrane-bound mucins: how large O-glycoproteins play key roles in epithelial cancers and hold promise as biological tools for gene-based and immunotherapies. Critical Reviews in Oncogenesis. 14: 177-96. PMID 19409062 DOI: 10.1615/Critrevoncog.V14.I2-3.30  0.686
2008 Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M. Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Developmental Biology. 318: 224-35. PMID 18452912 DOI: 10.1016/J.Ydbio.2008.03.014  0.421
2007 Jonckheere N, Vincent A, Perrais M, Ducourouble MP, Male AK, Aubert JP, Pigny P, Carraway KL, Freund JN, Renes IB, Van Seuningen I. The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. The Journal of Biological Chemistry. 282: 22638-50. PMID 17553805 DOI: 10.1074/Jbc.M700905200  0.79
2007 Piessen G, Jonckheere N, Vincent A, Hémon B, Ducourouble MP, Copin MC, Mariette C, Van Seuningen I. Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha. The Biochemical Journal. 402: 81-91. PMID 17037983 DOI: 10.1042/Bj20061461  0.801
2006 Rat E, Billaut-Laden I, Allorge D, Lo-Guidice JM, Tellier M, Cauffiez C, Jonckheere N, van Seuningen I, Lhermitte M, Romano A, Guéant JL, Broly F. Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. Birth Defects Research. Part a, Clinical and Molecular Teratology. 76: 491-8. PMID 16933217 DOI: 10.1002/Bdra.20275  0.573
2006 Renes I, Jonckheere N, Korteland-van Male A, Ducourouble M, Einerhand A, van Seuningen I. Regulation of murine Muc5ac mucin gene expression by GATA-6 and HNF-4?? transcription factors during stomach development European Journal of Gastroenterology & Hepatology. 18: A63. DOI: 10.1097/00042737-200601000-00199  0.336
2005 Fauquette V, Perrais M, Cerulis S, Jonckheere N, Ducourouble MP, Aubert JP, Pigny P, Van Seuningen I. The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells. The Biochemical Journal. 386: 35-45. PMID 15461591 DOI: 10.1042/Bj20040706  0.734
2004 van der Sluis M, Melis MH, Jonckheere N, Ducourouble MP, Büller HA, Renes I, Einerhand AW, Van Seuningen I. The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells. Biochemical and Biophysical Research Communications. 325: 952-60. PMID 15541382 DOI: 10.1016/J.Bbrc.2004.10.108  0.671
2004 Jonckheere N, Perrais M, Mariette C, Batra SK, Aubert JP, Pigny P, Van Seuningen I. A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis. Oncogene. 23: 5729-38. PMID 15184872 DOI: 10.1038/Sj.Onc.1207769  0.661
2004 Mariette C, Perrais M, Leteurtre E, Jonckheere N, Hémon B, Pigny P, Batra S, Aubert JP, Triboulet JP, Van Seuningen I. Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway. The Biochemical Journal. 377: 701-8. PMID 14583090 DOI: 10.1042/Bj20031132  0.651
2004 Jonckheere N, Van Der Sluis M, Velghe A, Buisine MP, Sutmuller M, Ducourouble MP, Pigny P, Büller HA, Aubert JP, Einerhand AW, Van Seuningen I. Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1. The Biochemical Journal. 377: 797-808. PMID 14570593 DOI: 10.1042/Bj20030948  0.645
2003 Mesquita P, Jonckheere N, Almeida R, Ducourouble MP, Serpa J, Silva E, Pigny P, Silva FS, Reis C, Silberg D, Van Seuningen I, David L. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. The Journal of Biological Chemistry. 278: 51549-56. PMID 14525978 DOI: 10.1074/Jbc.M309019200  0.644
2003 Jonckheere N, Perrais M, Mariette C, Ducourouble M, Aubert J, Pigny P, Van Seuningen I. Transcriptional regulation of human mucin gene MUC4 by TGF-β and EGF/TGF-α in pancreatic cancer cells involves a complex cross-talk between the Smads, MAPK, P13K, and PKA signaling pathways Gastroenterology. 124: A128. DOI: 10.1016/S0016-5085(03)80630-3  0.49
2003 Mariette C, Perrais M, Pigny P, Jonckheere N, Leteurtre E, Aubert J, Triboulet J, Van Seuningen I. Bile acids regulate MUC4 mucin gene expression at the transcriptional level in esophagus cancer cells. PI3K appears as the major signaling pathway Gastroenterology. 124: A126-A127. DOI: 10.1016/S0016-5085(03)80624-8  0.469
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