Brian K. Kennedy - Publications

Affiliations: 
Buck Institute for Research on Aging 

173 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Bailus BJ, Scheeler SM, Simons J, Sanchez MA, Tshilenge KT, Creus-Muncunill J, Naphade S, Lopez-Ramirez A, Zhang N, Lakshika Madushani K, Moroz S, Loureiro A, Schreiber KH, Hausch F, Kennedy BK, et al. Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy. 1-22. PMID 34024231 DOI: 10.1080/15548627.2021.1904489  0.772
2020 Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, et al. The conundrum of human immune system "senescence". Mechanisms of Ageing and Development. 111357. PMID 32949594 DOI: 10.1016/J.Mad.2020.111357  0.335
2020 Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metabolism. 32: 447-456.e6. PMID 32877690 DOI: 10.1016/J.Cmet.2020.08.004  0.339
2020 Zou K, Rouskin S, Dervishi K, McCormick MA, Sasikumar A, Deng C, Chen Z, Kaeberlein M, Brem RB, Polymenis M, Kennedy BK, Weissman JS, Zheng J, Ouyang Q, Li H. Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span. Science Advances. 6: eaba1306. PMID 32821821 DOI: 10.1126/Sciadv.Aba1306  0.305
2020 Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, et al. Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mechanisms of Ageing and Development. 111316. PMID 32693105 DOI: 10.1016/J.Mad.2020.111316  0.365
2020 Partridge L, Fuentealba M, Kennedy BK. The quest to slow ageing through drug discovery. Nature Reviews. Drug Discovery. PMID 32467649 DOI: 10.1038/S41573-020-0067-7  0.373
2020 Maitra N, He C, Blank HM, Tsuchiya M, Schilling B, Kaeberlein M, Aramayo R, Kennedy BK, Polymenis M. Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity. Elife. 9. PMID 32432546 DOI: 10.7554/Elife.53127  0.378
2020 Blank HM, Papoulas O, Maitra N, Garge R, Kennedy BK, Schilling B, Marcotte EM, Polymenis M. Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveal coordinate control of lipid metabolism. Molecular Biology of the Cell. mbcE19120708. PMID 32129706 DOI: 10.1091/Mbc.E19-12-0708  0.336
2020 Molenaars M, Janssens GE, Williams EG, Jongejan A, Lan J, Rabot S, Joly F, Moerland PD, Schomakers BV, Lezzerini M, Liu YJ, McCormick MA, Kennedy BK, van Weeghel M, van Kampen AHC, et al. A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways. Cell Metabolism. PMID 32084377 DOI: 10.1016/J.Cmet.2020.01.011  0.357
2020 Kudryashova KS, Burka K, Kulaga AY, Vorobyeva NS, Kennedy BK. Aging Biomarkers: From Functional Tests to Multi-Omics Approaches. Proteomics. e1900408. PMID 32084299 DOI: 10.1002/Pmic.201900408  0.372
2020 Maitra N, He C, Blank HM, Tsuchiya M, Schilling B, Kaeberlein M, Aramayo R, Kennedy BK, Polymenis M. Author response: Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity Elife. DOI: 10.7554/Elife.53127.Sa2  0.308
2019 Crane MM, Tsuchiya M, Blue BW, Almazan JD, Chen KL, Duffy SR, Golubeva A, Grimm AM, Guard AM, Hill SA, Huynh E, Kelly RM, Kiflezghi M, Kim HD, Lee M, ... ... Kennedy BK, et al. Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast. Translational Medicine of Aging. 3: 104-108. PMID 32190787 DOI: 10.1016/J.Tma.2019.10.002  0.385
2019 Hodgson R, Kennedy BK, Masliah E, Scearce-Levie K, Tate B, Venkateswaran A, Braithwaite SP. AGING: THERAPEUTICS FOR A HEALTHY FUTURE. Neuroscience and Biobehavioral Reviews. PMID 31783058 DOI: 10.1016/J.Neubiorev.2019.11.021  0.391
2019 Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner MI, Jensen MB, Calkhoven CF, Chen D, Grey ADNJ, Feige JN, Georgievskaya A, Gladyshev VN, Golato T, Gudkov AV, ... ... Kennedy BK, et al. Latest advances in aging research and drug discovery. Aging. 11. PMID 31770722 DOI: 10.18632/Aging.102487  0.362
2019 Schreiber KH, Arriola Apelo SI, Yu D, Brinkman JA, Velarde MC, Syed FA, Liao CY, Baar EL, Carbajal KA, Sherman DS, Ortiz D, Brunauer R, Yang SE, Tzannis ST, Kennedy BK, et al. A novel rapamycin analog is highly selective for mTORC1 in vivo. Nature Communications. 10: 3194. PMID 31324799 DOI: 10.1038/S41467-019-11174-0  0.777
2019 Lee JY, Kennedy BK, Liao CY. mTOR signaling in mouse models of accelerated aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 30900725 DOI: 10.1093/Gerona/Glz059  0.441
2019 Sasikumar AN, Killilea DW, Kennedy BK, Brem RB. Potassium restriction boosts vacuolar acidity and extends lifespan in yeast. Experimental Gerontology. PMID 30742903 DOI: 10.1016/J.Exger.2019.02.001  0.365
2019 Lau A, Kennedy BK, Kirkland JL, Tullius SG. Mixing old and young: enhancing rejuvenation and accelerating aging. The Journal of Clinical Investigation. 129: 4-11. PMID 30601138 DOI: 10.1172/Jci123946  0.347
2019 Kennedy BK. In search of an aging antidote Science. 363: 822-822. DOI: 10.1126/Science.Aaw2246  0.396
2018 Solis GM, Kardakaris R, Valentine ER, Bar-Peled L, Chen AL, Blewett MM, McCormick MA, Williamson JR, Kennedy B, Cravatt BF, Petrascheck M. Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms. Elife. 7. PMID 30479271 DOI: 10.7554/Elife.40314  0.399
2018 He C, Zhou C, Kennedy BK. The yeast replicative aging model. Biochimica Et Biophysica Acta. PMID 29524633 DOI: 10.1016/J.Bbadis.2018.02.023  0.418
2018 Huang J, Mousley CJ, Dacquay L, Maitra N, Drin G, He C, Ridgway ND, Tripathi A, Kennedy M, Kennedy BK, Liu W, Baetz K, Polymenis M, Bankaitis VA. A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems. Developmental Cell. PMID 29396115 DOI: 10.1016/J.Devcel.2017.12.026  0.364
2017 Thumala D, Kennedy BK, Calvo E, Gonzalez-Billault C, Zitko P, Lillo P, Villagra R, Ibáñez A, Assar R, Andrade M, Slachevsky A. Aging and Health Policies in Chile: New Agendas for Research. Health Systems and Reform. 3: 253-260. PMID 30359182 DOI: 10.1080/23288604.2017.1353844  0.334
2017 Liao CY, Anderson SS, Chicoine NH, Mayfield JR, Garrett BJ, Kwok CS, Academia EC, Hsu YM, Miller DM, Bair AM, Wilson JA, Tannady G, Stewart EM, Adamson SS, Wang J, ... ... Kennedy BK, et al. Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins. Cell Discovery. 3: 17039. PMID 29736257 DOI: 10.1038/Celldisc.2017.39  0.363
2017 Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H. mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Cell Stem Cell. 21: 806-818.e5. PMID 29220665 DOI: 10.1016/J.Stem.2017.11.008  0.782
2017 Kirkpatrick B, Kennedy BK. Accelerated aging in schizophrenia and related disorders: Future research. Schizophrenia Research. PMID 28689755 DOI: 10.1016/J.Schres.2017.06.034  0.323
2017 Gruber J, Kennedy BK. Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondria. Cell. 169: 1168-1169. PMID 28622501 DOI: 10.1016/J.Cell.2017.05.048  0.353
2017 Polymenis M, Kennedy BK. Unbalanced Growth, Senescence and Aging. Advances in Experimental Medicine and Biology. 1002: 189-208. PMID 28600787 DOI: 10.1007/978-3-319-57127-0_8  0.359
2017 Mason AG, Garza RM, McCormick MA, Patel B, Kennedy BK, Pillus L, La Spada AR. The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast. Aging Cell. PMID 28568901 DOI: 10.1111/Acel.12611  0.357
2017 Taneja R, Kennedy BK. T(ell)TALE signs of aging. Cell Research. PMID 28281540 DOI: 10.1038/Cr.2017.33  0.358
2017 Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, Labunskyy VM. CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Reports. 18: 1884-1892. PMID 28228255 DOI: 10.1016/J.Celrep.2017.01.077  0.364
2017 Moskalev A, Anisimov V, Aliper A, Artemov A, Asadullah K, Belsky D, Baranova A, de Grey A, Dixit VD, Debonneuil E, Dobrovolskaya E, Fedichev P, Fedintsev A, Fraifeld V, Franceschi C, ... ... Kennedy B, et al. A review of the biomedical innovations for healthy longevity. Aging. PMID 28132958 DOI: 10.18632/Aging.101163  0.313
2017 Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, Kappes DJ, Feng Q, Rhodes J, Amieux PS, Morris DR, Kennedy BK, Wiest DL. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell Reports. 18: 545-556. PMID 28076796 DOI: 10.1016/J.Celrep.2016.12.034  0.319
2017 Blank HM, Perez R, He C, Maitra N, Metz R, Hill J, Lin Y, Johnson CD, Bankaitis VA, Kennedy BK, Aramayo R, Polymenis M. Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells. The Embo Journal. PMID 28057705 DOI: 10.15252/Embj.201695050  0.346
2017 Adamson SS, Brace LE, Kennedy BK. Alcohol and aging: From epidemiology to mechanism Translational Medicine of Aging. 1: 18-23. DOI: 10.1016/J.Tma.2017.09.001  0.342
2016 Kennedy BK, Pennypacker JK. Mammalian Target of Rapamycin: A Target for (Lung) Diseases and Aging. Annals of the American Thoracic Society. 13: S398-S401. PMID 28005429 DOI: 10.1513/Annalsats.201609-680Aw  0.34
2016 Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, ... ... Kennedy BK, et al. Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discovery. PMID 27979832 DOI: 10.1158/2159-8290.Cd-16-0241  0.341
2016 Liao CY, Anderson SS, Chicoine NH, Mayfield JR, Academia EC, Wilson JA, Pongkietisak C, Thompson MA, Lagmay EP, Miller DM, Hsu YM, McCormick MA, O'Leary MN, Kennedy BK. Rapamycin Reverses Metabolic Deficits in Lamin A/C-Deficient Mice. Cell Reports. 17: 2542-2552. PMID 27926859 DOI: 10.1016/J.Celrep.2016.10.040  0.342
2016 Brunauer R, Alavez S, Kennedy BK. Stem Cell Models: A Guide to Understand and Mitigate Aging? Gerontology. PMID 27760416 DOI: 10.1159/000449501  0.399
2016 Kennedy BK, Lamming DW. The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging. Cell Metabolism. 23: 990-1003. PMID 27304501 DOI: 10.1016/J.Cmet.2016.05.009  0.38
2016 Hansen M, Kennedy BK. Does Longer Lifespan Mean Longer Healthspan? Trends in Cell Biology. PMID 27238421 DOI: 10.1016/J.Tcb.2016.05.002  0.327
2016 Moskalev A, Chernyagina E, Tsvetkov V, Fedintsev A, Shaposhnikov M, Krut'ko V, Zhavoronkov A, Kennedy BK. Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic. Aging Cell. PMID 26970234 DOI: 10.1111/Acel.12463  0.344
2016 McQuary PR, Liao CY, Chang JT, Kumsta C, She X, Davis A, Chu CC, Gelino S, Gomez-Amaro RL, Petrascheck M, Brill LM, Ladiges WC, Kennedy BK, Hansen M. C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension. Cell Reports. PMID 26923601 DOI: 10.1016/J.Celrep.2016.02.012  0.322
2016 Liao CY, Kennedy BK. SIRT6, oxidative stress, and aging. Cell Research. PMID 26780861 DOI: 10.1038/Cr.2016.8  0.336
2015 McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, ... ... Kennedy BK, et al. A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metabolism. PMID 26456335 DOI: 10.1016/J.Cmet.2015.09.008  0.409
2015 Nikolich-Žugich J, Goldman DP, Cohen PR, Cortese D, Fontana L, Kennedy BK, Mohler MJ, Olshansky SJ, Perls T, Perry D, Richardson A, Ritchie C, Wertheimer AM, Faragher RG, Fain MJ. Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 26419976 DOI: 10.1093/Gerona/Glv164  0.324
2015 Vijg J, Kennedy BK. The Essence of Aging. Gerontology. PMID 26389968 DOI: 10.1159/000439348  0.352
2015 Yang J, McCormick MA, Zheng J, Xie Z, Tsuchiya M, Tsuchiyama S, El-Samad H, Ouyang Q, Kaeberlein M, Kennedy BK, Li H. Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry. Proceedings of the National Academy of Sciences of the United States of America. 112: 11977-82. PMID 26351681 DOI: 10.1073/Pnas.1506054112  0.407
2015 Barbie DA, Kennedy BK. Doxycycline: new tricks for an old drug. Oncotarget. 6: 19336-7. PMID 26305845 DOI: 10.18632/Oncotarget.5111  0.375
2015 Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, ... ... Kennedy BK, et al. H3K36 methylation promotes longevity by enhancing transcriptional fidelity. Genes & Development. 29: 1362-1376. PMID 26159996 DOI: 10.1101/Gad.263707.115  0.37
2015 Tsai S, Sitzmann JM, Dastidar SG, Rodriguez AA, Vu SL, McDonald CE, Academia EC, O'Leary MN, Ashe TD, La Spada AR, Kennedy BK. Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity. The Journal of Clinical Investigation. PMID 26121750 DOI: 10.1172/Jci77361  0.349
2015 Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, ... ... Kennedy BK, et al. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism. PMID 26094889 DOI: 10.1016/J.Cmet.2015.05.012  0.36
2015 Brunauer R, Kennedy BK. Medicine. Progeria accelerates adult stem cell aging. Science (New York, N.Y.). 348: 1093-4. PMID 26045423 DOI: 10.1126/Science.Aac4214  0.384
2015 Cui HJ, Liu XG, McCormick M, Wasko BM, Zhao W, He X, Yuan Y, Fang BX, Sun XR, Kennedy BK, Suh Y, Zhou ZJ, Kaeberlein M, Feng WL. PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae. Age (Dordrecht, Netherlands). 37: 9788. PMID 25936926 DOI: 10.1007/S11357-015-9788-7  0.39
2015 Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 14: 497-510. PMID 25902704 DOI: 10.1111/Acel.12338  0.361
2015 Schreiber KH, Ortiz D, Academia EC, Anies AC, Liao CY, Kennedy BK. Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins. Aging Cell. 14: 265-73. PMID 25652038 DOI: 10.1111/Acel.12313  0.782
2015 Yao Y, Tsuchiyama S, Yang C, Bulteau AL, He C, Robison B, Tsuchiya M, Miller D, Briones V, Tar K, Potrero A, Friguet B, Kennedy BK, Schmidt M. Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1. Plos Genetics. 11: e1004968. PMID 25629410 DOI: 10.1371/Journal.Pgen.1004968  0.445
2015 Kennedy BK, Pennypacker JK. Aging interventions get human. Oncotarget. 6: 590-1. PMID 25612254 DOI: 10.18632/Oncotarget.3173  0.399
2014 He C, Tsuchiyama SK, Nguyen QT, Plyusnina EN, Terrill SR, Sahibzada S, Patel B, Faulkner AR, Shaposhnikov MV, Tian R, Tsuchiya M, Kaeberlein M, Moskalev AA, Kennedy BK, Polymenis M. Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. Plos Genetics. 10: e1004860. PMID 25521617 DOI: 10.1371/Journal.Pgen.1004860  0.393
2014 Zhou C, Li R, Kennedy BK. Life history: mother-specific proteins that promote aging. Current Biology : Cb. 24: R1162-4. PMID 25514007 DOI: 10.1016/J.Cub.2014.11.007  0.397
2014 Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F. Geroscience: linking aging to chronic disease. Cell. 159: 709-13. PMID 25417146 DOI: 10.1016/J.Cell.2014.10.039  0.346
2014 McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell Reports. 8: 477-86. PMID 25043177 DOI: 10.1016/J.Celrep.2014.06.037  0.34
2014 Liao CY, Kennedy BK. Mouse models and aging: longevity and progeria. Current Topics in Developmental Biology. 109: 249-85. PMID 24947239 DOI: 10.1016/B978-0-12-397920-9.00003-2  0.389
2014 Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, ... Kennedy BK, et al. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metabolism. 19: 952-66. PMID 24814484 DOI: 10.1016/J.Cmet.2014.04.004  0.352
2014 Hu J, Wei M, Mirzaei H, Madia F, Mirisola M, Amparo C, Chagoury S, Kennedy B, Longo VD. Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell. 13: 457-67. PMID 24649827 DOI: 10.1111/Acel.12202  0.321
2014 Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, et al. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metabolism. 19: 407-17. PMID 24606898 DOI: 10.1016/J.Cmet.2014.02.006  0.339
2014 Kennedy BK, Pennypacker JK. RB and lamins in cell cycle regulation and aging. Advances in Experimental Medicine and Biology. 773: 127-42. PMID 24563346 DOI: 10.1007/978-1-4899-8032-8_6  0.43
2014 Adams P, Antebi A, Cuervo AM, Kennedy B, Sedivy J. Aging Cell: open access to all. Aging Cell. 13: 1. PMID 24433409 DOI: 10.1111/Acel.12187  0.37
2014 Labunskyy VM, Gerashchenko MV, Delaney JR, Kaya A, Kennedy BK, Kaeberlein M, Gladyshev VN. Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. Plos Genetics. 10: e1004019. PMID 24391512 DOI: 10.1371/Journal.Pgen.1004019  0.368
2014 Kennedy BK, Pennypacker JK. Drugs that modulate aging: the promising yet difficult path ahead. Translational Research : the Journal of Laboratory and Clinical Medicine. 163: 456-65. PMID 24316383 DOI: 10.1016/J.Trsl.2013.11.007  0.405
2013 Das A, Grotsky DA, Neumann MA, Kreienkamp R, Gonzalez-Suarez I, Redwood AB, Kennedy BK, Stewart CL, Gonzalo S. Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability. Nucleus (Austin, Tex.). 4: 410-9. PMID 24153156 DOI: 10.4161/Nucl.26873  0.325
2013 Cai L, McCormick MA, Kennedy BK, Tu BP. Integration of multiple nutrient cues and regulation of lifespan by ribosomal transcription factor Ifh1. Cell Reports. 4: 1063-71. PMID 24035395 DOI: 10.1016/J.Celrep.2013.08.016  0.361
2013 Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK. Sirtuins in yeast: phenotypes and tools. Methods in Molecular Biology (Clifton, N.J.). 1077: 11-37. PMID 24014397 DOI: 10.1007/978-1-62703-637-5_2  0.427
2013 O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, ... ... Kennedy BK, et al. The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. Plos Genetics. 9: e1003708. PMID 23990801 DOI: 10.1371/Journal.Pgen.1003708  0.768
2013 Kennedy BK. A new connection between VHL and cancer threads through progerin. Cell Cycle (Georgetown, Tex.). 12: 2721-2. PMID 23966149 DOI: 10.4161/Cc.26158  0.381
2013 Garelick MG, Mackay VL, Yanagida A, Academia EC, Schreiber KH, Ladiges WC, Kennedy BK. Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo. Cell Cycle (Georgetown, Tex.). 12: 2493-504. PMID 23839034 DOI: 10.4161/Cc.25512  0.764
2013 Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Carr D, Murakami CJ, Tocchi A, Xian B, ... ... Kennedy BK, et al. Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell. 12: 1050-61. PMID 23837470 DOI: 10.1111/Acel.12130  0.363
2013 Flynn JM, O'Leary MN, Zambataro CA, Academia EC, Presley MP, Garrett BJ, Zykovich A, Mooney SD, Strong R, Rosen CJ, Kapahi P, Nelson MD, Kennedy BK, Melov S. Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell. 12: 851-62. PMID 23734717 DOI: 10.1111/Acel.12109  0.374
2013 Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. Plos Genetics. 9: e1003329. PMID 23505383 DOI: 10.1371/Journal.Pgen.1003329  0.305
2013 Schreiber KH, Kennedy BK. When lamins go bad: nuclear structure and disease. Cell. 152: 1365-75. PMID 23498943 DOI: 10.1016/J.Cell.2013.02.015  0.765
2013 Delaney JR, Chou A, Olsen B, Carr D, Murakami C, Ahmed U, Sim S, An EH, Castanza AS, Fletcher M, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, ... ... Kennedy BK, et al. End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. Fems Yeast Research. 13: 267-76. PMID 23336757 DOI: 10.1111/1567-1364.12030  0.343
2013 Adams P, Antebi A, Cuervo AM, Kennedy B, Sedivy J. Aging Cell in 2012. Editorial. Aging Cell. 12: 1. PMID 23331410 DOI: 10.1111/Acel.12037  0.38
2013 Chen SC, Kennedy BK, Lampe PD. Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects. Experimental Cell Research. 319: 888-96. PMID 23261543 DOI: 10.1016/J.Yexcr.2012.12.014  0.328
2013 Delaney JR, Ahmed U, Chou A, Sim S, Carr D, Murakami CJ, Schleit J, Sutphin GL, An EH, Castanza A, Fletcher M, Higgins S, Jelic M, Klum S, Muller B, ... ... Kennedy BK, et al. Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell. 12: 156-66. PMID 23167605 DOI: 10.1111/Acel.12032  0.369
2013 Ramos FJ, Kaeberlein M, Kennedy BK. Elevated MTORC1 signaling and impaired autophagy. Autophagy. 9: 108-9. PMID 23064282 DOI: 10.4161/Auto.22401  0.351
2013 Adams P, Antebi A, Cuervo AM, Kennedy B, Sedivy J. Aging Cell Prize for Best Paper 2012 Aging Cell. 12: 1148-1148. DOI: 10.1111/Acel.12162  0.366
2012 McCormick MA, Kennedy BK. Genome-scale studies of aging: challenges and opportunities. Current Genomics. 13: 500-7. PMID 23633910 DOI: 10.2174/138920212803251454  0.329
2012 Schmidt M, Kennedy BK. Aging: one thing leads to another. Current Biology : Cb. 22: R1048-51. PMID 23257191 DOI: 10.1016/J.Cub.2012.11.016  0.358
2012 Liu B, Ghosh S, Yang X, Zheng H, Liu X, Wang Z, Jin G, Zheng B, Kennedy BK, Suh Y, Kaeberlein M, Tryggvason K, Zhou Z. Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metabolism. 16: 738-50. PMID 23217256 DOI: 10.1016/J.Cmet.2012.11.007  0.37
2012 Lockshon D, Olsen CP, Brett CL, Chertov A, Merz AJ, Lorenz DA, Van Gilst MR, Kennedy BK. Rho signaling participates in membrane fluidity homeostasis. Plos One. 7: e45049. PMID 23071506 DOI: 10.1371/Journal.Pone.0045049  0.316
2012 Polymenis M, Kennedy BK. Chronological and replicative lifespan in yeast: do they meet in the middle? Cell Cycle (Georgetown, Tex.). 11: 3531-2. PMID 22951539 DOI: 10.4161/Cc.22041  0.426
2012 Jasper H, Kennedy BK. Niche science: the aging stem cell. Cell Cycle (Georgetown, Tex.). 11: 2959-60. PMID 22926561 DOI: 10.4161/Cc.21558  0.341
2012 Frock RL, Chen SC, Da DF, Frett E, Lau C, Brown C, Pak DN, Wang Y, Muchir A, Worman HJ, Santana LF, Ladiges WC, Rabinovitch PS, Kennedy BK. Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice. Plos One. 7: e42918. PMID 22905185 DOI: 10.1371/Journal.Pone.0042918  0.316
2012 Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK. Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Science Translational Medicine. 4: 144ra103. PMID 22837538 DOI: 10.1126/Scitranslmed.3003802  0.762
2012 Tsuchiyama S, Kennedy BK. Vacuolar dynamics and replicative aging. Cell Cycle (Georgetown, Tex.). 11: 2778-9. PMID 22825310 DOI: 10.4161/Cc.21393  0.416
2012 Longo VD, Shadel GS, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metabolism. 16: 18-31. PMID 22768836 DOI: 10.1016/J.Cmet.2012.06.002  0.403
2012 Kennedy B. Gerontology: more funding for studies of ageing. Nature. 487: 39. PMID 22763541 DOI: 10.1038/487039A  0.348
2012 Polymenis M, Kennedy BK. Cell biology: High-tech yeast ageing. Nature. 486: 37-8. PMID 22678274 DOI: 10.1038/486037A  0.382
2012 Liao CY, Kennedy BK. Will the real aging Sirtuin please stand up? Cell Research. 22: 1215-7. PMID 22508266 DOI: 10.1038/Cr.2012.62  0.351
2012 Hughes KJ, Kennedy BK. Cell biology. Rapamycin paradox resolved. Science (New York, N.Y.). 335: 1578-9. PMID 22461595 DOI: 10.1126/Science.1221365  0.359
2012 Steffen KK, McCormick MA, Pham KM, MacKay VL, Delaney JR, Murakami CJ, Kaeberlein M, Kennedy BK. Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. Genetics. 191: 107-18. PMID 22377630 DOI: 10.1534/Genetics.111.136549  0.346
2012 Kaeberlein M, Kennedy BK. A new chronological survival assay in mammalian cell culture. Cell Cycle (Georgetown, Tex.). 11: 201-2. PMID 22214665 DOI: 10.4161/Cc.11.2.18959  0.388
2012 Sutphin GL, Olsen BA, Kennedy BK, Kaeberlein M. Genome-wide analysis of yeast aging. Sub-Cellular Biochemistry. 57: 251-89. PMID 22094426 DOI: 10.1007/978-94-007-2561-4_12  0.342
2011 Kruegel U, Robison B, Dange T, Kahlert G, Delaney JR, Kotireddy S, Tsuchiya M, Tsuchiyama S, Murakami CJ, Schleit J, Sutphin G, Carr D, Tar K, Dittmar G, Kaeberlein M, ... Kennedy BK, et al. Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. Plos Genetics. 7: e1002253. PMID 21931558 DOI: 10.1371/Journal.Pgen.1002253  0.453
2011 Delaney JR, Sutphin GL, Dulken B, Sim S, Kim JR, Robison B, Schleit J, Murakami CJ, Carr D, An EH, Choi E, Chou A, Fletcher M, Jelic M, Liu B, ... ... Kennedy BK, et al. Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell. 10: 1089-91. PMID 21902802 DOI: 10.1111/J.1474-9726.2011.00742.X  0.366
2011 Lunyak VV, Kennedy BK. Aged worms erase epigenetic history. Cell Metabolism. 14: 147-8. PMID 21803283 DOI: 10.1016/J.Cmet.2011.07.008  0.351
2011 Kaeberlein M, Kennedy BK, Liu X, Suh Y, Zhou Z. Trinations aging symposium. Mechanisms of Ageing and Development. 132: 348-52. PMID 21771608 DOI: 10.1016/J.Mad.2011.07.001  0.372
2011 Chen SC, Frett E, Marx J, Bosnakovski D, Reed X, Kyba M, Kennedy BK. Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1. Plos One. 6: e19780. PMID 21603621 DOI: 10.1371/Journal.Pone.0019780  0.327
2011 Burtner CR, Murakami CJ, Olsen B, Kennedy BK, Kaeberlein M. A genomic analysis of chronological longevity factors in budding yeast. Cell Cycle (Georgetown, Tex.). 10: 1385-96. PMID 21447998 DOI: 10.4161/Cc.10.9.15464  0.368
2011 Delaney JR, Murakami CJ, Olsen B, Kennedy BK, Kaeberlein M. Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle (Georgetown, Tex.). 10: 156-65. PMID 21191185 DOI: 10.4161/Cc.10.1.14457  0.325
2011 Kaeberlein M, Kennedy BK. Hot topics in aging research: protein translation and TOR signaling, 2010. Aging Cell. 10: 185-90. PMID 21176090 DOI: 10.1111/J.1474-9726.2010.00665.X  0.388
2011 McCormick MA, Tsai SY, Kennedy BK. TOR and ageing: a complex pathway for a complex process. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 366: 17-27. PMID 21115526 DOI: 10.1098/Rstb.2010.0198  0.424
2011 Garelick MG, Kennedy BK. TOR on the brain. Experimental Gerontology. 46: 155-63. PMID 20849946 DOI: 10.1016/J.Exger.2010.08.030  0.381
2011 Antebi A, Cuervo AM, Kennedy B, Martin G, Sedivy J. Aging Cell Prize for Best Paper 2010 Aging Cell. 10: 1092-1092. DOI: 10.1111/J.1474-9726.2011.00761.X  0.366
2010 McCormick MA, Kennedy BK. Old yeast can't handle the noise. Molecular Cell. 39: 659-61. PMID 20832716 DOI: 10.1016/J.Molcel.2010.08.033  0.35
2010 Oh YS, Kim DG, Kim G, Choi EC, Kennedy BK, Suh Y, Park BJ, Kim S. Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice. Aging Cell. 9: 810-22. PMID 20726853 DOI: 10.1111/J.1474-9726.2010.00614.X  0.426
2010 Burtner CR, Kennedy BK. Progeria syndromes and ageing: what is the connection? Nature Reviews. Molecular Cell Biology. 11: 567-78. PMID 20651707 DOI: 10.1038/Nrm2944  0.383
2010 Hale JS, Frock RL, Mamman SA, Fink PJ, Kennedy BK. Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice. Plos One. 5: e10127. PMID 20405040 DOI: 10.1371/Journal.Pone.0010127  0.352
2009 Enns LC, Morton JF, Mangalindan RS, McKnight GS, Schwartz MW, Kaeberlein MR, Kennedy BK, Rabinovitch PS, Ladiges WC. Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 64: 1221-31. PMID 19776218 DOI: 10.1093/Gerona/Glp133  0.377
2009 Schmidlin T, Kennedy BK, Daggett V. Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V. Biophysical Journal. 97: 1709-18. PMID 19751676 DOI: 10.1016/J.Bpj.2009.06.043  0.304
2009 Kennedy BK, Kaeberlein M. Hot topics in aging research: protein translation, 2009. Aging Cell. 8: 617-23. PMID 19747234 DOI: 10.1111/J.1474-9726.2009.00522.X  0.394
2009 Kaeberlein M, Kennedy BK. Ageing: A midlife longevity drug? Nature. 460: 331-2. PMID 19606132 DOI: 10.1038/460331A  0.328
2009 Steffen KK, Kennedy BK, Kaeberlein M. Measuring replicative life span in the budding yeast. Journal of Visualized Experiments : Jove. PMID 19556967 DOI: 10.3791/1209  0.391
2009 Stanfel MN, Shamieh LS, Kaeberlein M, Kennedy BK. The TOR pathway comes of age. Biochimica Et Biophysica Acta. 1790: 1067-74. PMID 19539012 DOI: 10.1016/J.Bbagen.2009.06.007  0.392
2009 Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, Berger SL. Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature. 459: 802-7. PMID 19516333 DOI: 10.1038/Nature08085  0.344
2009 Burtner CR, Murakami CJ, Kennedy BK, Kaeberlein M. A molecular mechanism of chronological aging in yeast. Cell Cycle (Georgetown, Tex.). 8: 1256-70. PMID 19305133 DOI: 10.4161/Cc.8.8.8287  0.388
2009 Lee DC, Welton KL, Smith ED, Kennedy BK. A-type nuclear lamins act as transcriptional repressors when targeted to promoters. Experimental Cell Research. 315: 996-1007. PMID 19272320 DOI: 10.1016/J.Yexcr.2009.01.003  0.315
2008 Managbanag JR, Witten TM, Bonchev D, Fox LA, Tsuchiya M, Kennedy BK, Kaeberlein M. Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. Plos One. 3: e3802. PMID 19030232 DOI: 10.1371/Journal.Pone.0003802  0.356
2008 Kudlow BA, Stanfel MN, Burtner CR, Johnston ED, Kennedy BK. Suppression of Proliferative Defects Associated with Processing-defective Lamin A Mutants by hTERT or Inactivation of p53 Molecular Biology of the Cell. 19: 5238-5248. PMID 18843043 DOI: 10.1091/Mbc.E08-05-0492  0.377
2008 Kaeberlein M, Kennedy BK. Protein translation, 2008. Aging Cell. 7: 777-782. PMID 18782345 DOI: 10.1111/J.1474-9726.2008.00439.X  0.356
2008 Steinkraus KA, Kaeberlein M, Kennedy BK. Replicative aging in yeast: the means to the end. Annual Review of Cell and Developmental Biology. 24: 29-54. PMID 18616424 DOI: 10.1146/Annurev.Cellbio.23.090506.123509  0.407
2008 Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, Fox LA, Dang N, Johnston ED, Oakes JA, Tchao BN, Pak DN, Fields S, Kennedy BK, Kaeberlein M. Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell. 133: 292-302. PMID 18423200 DOI: 10.1016/J.Cell.2008.02.037  0.386
2008 Smith ED, Tsuchiya M, Fox LA, Dang N, Hu D, Kerr EO, Johnston ED, Tchao BN, Pak DN, Welton KL, Promislow DE, Thomas JH, Kaeberlein M, Kennedy BK. Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Research. 18: 564-70. PMID 18340043 DOI: 10.1101/Gr.074724.107  0.393
2008 Steinkraus KA, Smith ED, Davis C, Carr D, Pendergrass WR, Sutphin GL, Kennedy BK, Kaeberlein M. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell. 7: 394-404. PMID 18331616 DOI: 10.1111/J.1474-9726.2008.00385.X  0.385
2008 Murakami CJ, Burtner CR, Kennedy BK, Kaeberlein M. A method for high-throughput quantitative analysis of yeast chronological life span. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 63: 113-21. PMID 18314444 DOI: 10.1093/Gerona/63.2.113  0.342
2008 Kennedy BK. The genetics of ageing: insight from genome-wide approaches in invertebrate model organisms. Journal of Internal Medicine. 263: 142-152. PMID 18226092 DOI: 10.1111/J.1365-2796.2007.01903.X  0.351
2007 Kaeberlein M, Kennedy BK. Protein translation, 2007 Aging Cell. 6: 731-734. PMID 17941970 DOI: 10.1111/J.1474-9726.2007.00341.X  0.397
2007 Nitta RT, Smith CL, Kennedy BK. Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2. Plos One. 2. PMID 17896003 DOI: 10.1371/Journal.Pone.0000963  0.373
2007 Kaeberlein M, Burtner CR, Kennedy BK. Recent Developments in Yeast Aging Plos Genetics. 3. PMID 17530929 DOI: 10.1371/Journal.Pgen.0030084  0.4
2007 Kudlow BA, Kennedy BK, Monnat RJ. Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nature Reviews. Molecular Cell Biology. 8: 394-404. PMID 17450177 DOI: 10.1038/Nrm2161  0.316
2007 Kennedy BK, Steffen KK, Kaeberlein M. Ruminations on dietary restriction and aging. Cellular and Molecular Life Sciences. 64: 1323-1328. PMID 17396225 DOI: 10.1007/S00018-007-6470-Y  0.353
2007 Lockshon D, Surface LE, Kerr EO, Kaeberlein M, Kennedy BK. The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics. 175: 77-91. PMID 17151231 DOI: 10.1534/Genetics.106.064428  0.305
2007 Smith ED, Kennedy BK, Kaeberlein M. Genome-wide identification of conserved longevity genes in yeast and worms. Mechanisms of Ageing and Development. 128: 106-11. PMID 17126379 DOI: 10.1016/J.Mad.2006.11.017  0.358
2006 Tsuchiya M, Dang N, Kerr EO, Hu D, Steffen KK, Oakes JA, Kennedy BK, Kaeberlein M. Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging Cell. 5: 505-14. PMID 17129213 DOI: 10.1111/J.1474-9726.2006.00240.X  0.316
2006 Kudlow BA, Kennedy BK. Aging: Progeria and the Lamin Connection Current Biology. 16. PMID 16920618 DOI: 10.1016/J.Cub.2006.07.029  0.387
2006 Longo VD, Kennedy BK. Sirtuins in aging and age-related disease. Cell. 126: 257-68. PMID 16873059 DOI: 10.1016/J.Cell.2006.07.002  0.383
2006 Nitta RT, Jameson SA, Kudlow BA, Conlan LA, Kennedy BK. Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest. Molecular and Cellular Biology. 26: 5360-72. PMID 16809772 DOI: 10.1128/Mcb.02464-05  0.369
2006 Xu Y, Leung CG, Lee DC, Kennedy BK, Crispino JD. MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation. Leukemia. 20: 1261-9. PMID 16673016 DOI: 10.1038/Sj.Leu.2404252  0.34
2006 Frock RL, Kudlow BA, Evans AM, Jameson SA, Hauschka SD, Kennedy BK. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes & Development. 20: 486-500. PMID 16481476 DOI: 10.1101/Gad.1364906  0.35
2006 Powers RW, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes & Development. 20: 174-84. PMID 16418483 DOI: 10.1101/Gad.1381406  0.382
2005 Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N, Fields S, Kennedy BK. Increased life span due to calorie restriction in respiratory-deficient yeast. Plos Genetics. 1: e69. PMID 16311627 DOI: 10.1371/Journal.Pgen.0010069  0.331
2005 Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (New York, N.Y.). 310: 1193-6. PMID 16293764 DOI: 10.1126/Science.1115535  0.338
2005 Kennedy BK, Smith ED, Kaeberlein M. The enigmatic role of Sir2 in aging. Cell. 123: 548-50. PMID 16286003 DOI: 10.1016/J.Cell.2005.11.002  0.371
2005 Kaeberlein M, Kirkland KT, Fields S, Kennedy BK. Genes determining yeast replicative life span in a long-lived genetic background. Mechanisms of Ageing and Development. 126: 491-504. PMID 15722108 DOI: 10.1016/J.Mad.2004.10.007  0.367
2005 Smith ED, Kudlow BA, Frock RL, Kennedy BK. A-type nuclear lamins, progerias and other degenerative disorders. Mechanisms of Ageing and Development. 126: 447-60. PMID 15722103 DOI: 10.1016/J.Mad.2004.10.006  0.321
2005 Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Substrate-specific activation of sirtuins by resveratrol. The Journal of Biological Chemistry. 280: 17038-45. PMID 15684413 DOI: 10.1074/Jbc.M500655200  0.344
2005 Kaeberlein M, Kennedy BK. Large-scale identification in yeast of conserved ageing genes Mechanisms of Ageing and Development. 126: 17-21. PMID 15610758 DOI: 10.1016/J.Mad.2004.09.013  0.41
2005 Huang S, Kennedy BK, Oshima J. LMNA mutations in progeroid syndromes. Novartis Foundation Symposium. 264: 197-207. DOI: 10.1002/0470093765.Ch13  0.324
2004 Kaeberlein M, Kirkland KT, Fields S, Kennedy BK. Sir2-independent life span extension by calorie restriction in yeast. Plos Biology. 2: E296. PMID 15328540 DOI: 10.1371/Journal.Pbio.0020296  0.422
2004 Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E, Kennedy BK. A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proceedings of the National Academy of Sciences of the United States of America. 101: 9677-82. PMID 15210943 DOI: 10.1073/Pnas.0403250101  0.368
2004 Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E, Kennedy BK. Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit. Molecular and Cellular Biology. 24: 595-607. PMID 14701733 DOI: 10.1128/Mcb.24.2.595-607.2004  0.305
2002 Kennedy BK. Mammalian transcription factors in yeast: strangers in a familiar land Nature. 3: 41. PMID 11823797 DOI: 10.1038/Nrm704  0.309
2001 Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC, Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E, Branton PE. RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Molecular and Cellular Biology. 21: 2918-32. PMID 11283269 DOI: 10.1128/Mcb.21.8.2918-2932.2001  0.326
2000 Classon M, Kennedy BK, Mulloy R, Harlow E. Opposing roles of pRB and p107 in adipocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America. 97: 10826-31. PMID 10995476 DOI: 10.1073/Pnas.190343597  0.308
2000 Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes & Development. 14: 2283-97. PMID 10995386 DOI: 10.1101/Gad.827700  0.313
2000 Hannan KM, Kennedy BK, Cavanaugh AH, Hannan RD, Hirschler-Laszkiewicz I, Jefferson LS, Rothblum LI. RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest Oncogene. 19: 3487-3497. PMID 10918607 DOI: 10.1038/Sj.Onc.1203690  0.347
1997 Gotta M, Strahl-Bolsinger S, Renauld H, Laroche T, Kennedy BK, Grunstein M, Gasser SM. Localization of Sir2p: the nucleolus as a compartment for silent information regulators. The Embo Journal. 16: 3243-55. PMID 9214640 DOI: 10.1093/Emboj/16.11.3243  0.306
1997 Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM, Guarente L. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell. 89: 381-91. PMID 9150138 DOI: 10.1016/S0092-8674(00)80219-6  0.424
1996 Kennedy BK, Guarente L. Genetic analysis of aging in Saccharomyces cerevisiae Trends in Genetics. 12: 355-359. PMID 8855665 DOI: 10.1016/S0168-9525(96)80018-7  0.386
1996 Smeal T, Claus J, Kennedy B, Cole F, Guarente L. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae Cell. 84: 633-642. PMID 8598049 DOI: 10.1016/S0092-8674(00)81038-7  0.408
1995 Kennedy BK, Austriaco NR, Zhang J, Guarente L. Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae Cell. 80: 485-496. PMID 7859289 DOI: 10.1016/0092-8674(95)90499-9  0.378
1995 Prendergast JA, Singer RA, Rowley N, Rowley A, Johnston GC, Danos M, Kennedy B, Gaber RF. Mutations sensitizing yeast cells to the start inhibitor nalidixic acid. Yeast (Chichester, England). 11: 537-47. PMID 7645344 DOI: 10.1002/Yea.320110603  0.33
1994 Kennedy BK, Austriaco NR, Guarente L. Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span Journal of Cell Biology. 127: 1985-1993. PMID 7806576 DOI: 10.1083/Jcb.127.6.1985  0.308
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