☰

Lee Zou - Publications

Affiliations: 
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
 MGH Harvard Medical School, Boston, MA, United States 
Website:
http://www.massgeneral.org/cancerresearch/research/researchlab.aspx?id=1198
Tree Info Similar researchers PubMed Report error

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wang Y, Gao B, Zhang L, Wang X, Zhu X, Yang H, Zhang F, Zhu X, Zhou B, Yao S, Nagayama A, Lee S, Ouyang J, Koh SB, Eisenhauer EL, ... ... Zou L, et al. Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair. Nature Communications. 15: 1568. PMID 38383600 DOI: 10.1038/s41467-024-45693-2  0.45
2024 Kawale AS, Ran X, Patel PS, Saxena S, Lawrence MS, Zou L. APOBEC3A induces DNA gaps through PRIMPOL and confers gap-associated therapeutic vulnerability. Science Advances. 10: eadk2771. PMID 38241374 DOI: 10.1126/sciadv.adk2771  0.835
2023 Wang M, Ran X, Leung W, Kawale A, Saxena S, Ouyang J, Patel PS, Dong Y, Yin T, Shu J, Manguso RT, Lan L, Wang XF, Lawrence MS, Zou L. ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy. Genes & Development. PMID 37932012 DOI: 10.1101/gad.351084.123  0.8
2023 Joo YK, Black EM, Trier I, Haakma W, Zou L, Kabeche L. ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei. Molecular Cell. 83: 3642-3658.e4. PMID 37788673 DOI: 10.1016/j.molcel.2023.09.003  0.458
2023 Yang H, Lachtara EM, Ran X, Hopkins J, Patel PS, Zhu X, Xiao Y, Phoon L, Gao B, Zou L, Lawrence MS, Lan L. The RNA m5C modification in R-loops as an off switch of Alt-NHEJ. Nature Communications. 14: 6114. PMID 37777505 DOI: 10.1038/s41467-023-41790-w  0.695
2023 Igarashi T, Mazevet M, Yasuhara T, Yano K, Mochizuki A, Nishino M, Yoshida T, Yoshida Y, Takamatsu N, Yoshimi A, Shiraishi K, Horinouchi H, Kohno T, Hamamoto R, Adachi J, ... Zou L, et al. An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress. Nature Communications. 14: 4991. PMID 37591859 DOI: 10.1038/s41467-023-40578-2  0.342
2023 Leung W, Simoneau A, Saxena S, Jackson J, Patel PS, Limbu M, Vindigni A, Zou L. ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms. Cell Reports. 42: 112792. PMID 37454295 DOI: 10.1016/j.celrep.2023.112792  0.847
2023 Zou L. Heterochromatin-Dependent Replication Stress: A Lesson from IDH1/2 Mutants. Cancer Research. 83: 2987-2989. PMID 37433029 DOI: 10.1158/0008-5472.CAN-23-2015  0.448
2023 Isozaki H, Sakhtemani R, Abbasi A, Nikpour N, Stanzione M, Oh S, Langenbucher A, Monroe S, Su W, Cabanos HF, Siddiqui FM, Phan N, Jalili P, Timonina D, Bilton S, ... ... Zou L, et al. Therapy-induced APOBEC3A drives evolution of persistent cancer cells. Nature. PMID 37407818 DOI: 10.1038/s41586-023-06303-1  0.523
2023 Bamezai S, Pulikkottil AJ, Yadav T, Naidu VM, Mueller J, Mark J, Mandal T, Feder KA, Lehle S, Song C, Rosler R, Wiese S, Hoell JI, Kloetgen A, Karsan A, ... ... Zou L, et al. A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML. Blood. PMID 37146239 DOI: 10.1182/blood.2022018651  0.795
2022 Yadav T, Zhang JM, Ouyang J, Leung W, Simoneau A, Zou L. TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch. Molecular Cell. 82: 3985-4000.e4. PMID 36265486 DOI: 10.1016/j.molcel.2022.09.026  0.745
2022 Zhang JM, Zou L. Protocol to stimulate and delineate alternative lengthening of telomeres in human U2OS cells. Star Protocols. 3: 101594. PMID 35942347 DOI: 10.1016/j.xpro.2022.101594  0.377
2022 Saxena S, Zou L. Hallmarks of DNA replication stress. Molecular Cell. 82: 2298-2314. PMID 35714587 DOI: 10.1016/j.molcel.2022.05.004  0.825
2022 Yasuhara T, Xing YH, Bauer NC, Lee L, Dong R, Yadav T, Soberman RJ, Rivera MN, Zou L. Condensates induced by transcription inhibition localize active chromatin to nucleoli. Molecular Cell. PMID 35662392 DOI: 10.1016/j.molcel.2022.05.010  0.778
2022 Stanzione M, Zhong J, Wong E, LaSalle TJ, Wise JF, Simoneau A, Myers DT, Phat S, Sade-Feldman M, Lawrence MS, Hadden MK, Zou L, Farago AF, Dyson NJ, Drapkin BJ. Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer. Science Advances. 8: eabn1229. PMID 35559669 DOI: 10.1126/sciadv.abn1229  0.654
2022 Petermann E, Lan L, Zou L. Author Correction: Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids. Nature Reviews. Molecular Cell Biology. 23: 444. PMID 35513719 DOI: 10.1038/s41580-022-00494-7  0.365
2022 Suski JM, Ratnayeke N, Braun M, Zhang T, Strmiska V, Michowski W, Can G, Simoneau A, Snioch K, Cup M, Sullivan CM, Wu X, Nowacka J, Branigan TB, Pack LR, ... ... Zou L, et al. CDC7-independent G1/S transition revealed by targeted protein degradation. Nature. PMID 35508654 DOI: 10.1038/s41586-022-04698-x  0.323
2022 Petermann E, Lan L, Zou L. Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids. Nature Reviews. Molecular Cell Biology. PMID 35459910 DOI: 10.1038/s41580-022-00474-x  0.53
2022 Hopkins JL, Lan L, Zou L. DNA repair defects in cancer and therapeutic opportunities. Genes & Development. 36: 278-293. PMID 35318271 DOI: 10.1101/gad.349431.122  0.493
2022 Yang H, Wang Y, Xiang Y, Yadav T, Ouyang J, Phoon L, Zhu X, Shi Y, Zou L, Lan L. FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation. Proceedings of the National Academy of Sciences of the United States of America. 119: e2116251119. PMID 35290126 DOI: 10.1073/pnas.2116251119  0.817
2022 Yasuhara T, Kato R, Yamauchi M, Uchihara Y, Zou L, Miyagawa K, Shibata A. RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair. Cell Reports. 38: 110335. PMID 35108530 DOI: 10.1016/j.celrep.2022.110335  0.492
2022 Krishnan B, Yasuhara T, Rumde P, Stanzione M, Lu C, Lee H, Lawrence MS, Zou L, Nieman LT, Sanidas I, Dyson NJ. Active RB causes visible changes in nuclear organization. The Journal of Cell Biology. 221. PMID 35019938 DOI: 10.1083/jcb.202102144  0.526
2021 Kang Z, Fu P, Alcivar AL, Fu H, Redon C, Foo TK, Zuo Y, Ye C, Baxley R, Madireddy A, Buisson R, Bielinsky AK, Zou L, Shen Z, Aladjem MI, et al. BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage. Nature Communications. 12: 5966. PMID 34645815 DOI: 10.1038/s41467-021-26227-6  0.566
2021 Guo H, Golczer G, Wittner BS, Langenbucher A, Zachariah M, Dubash TD, Hong X, Comaills V, Burr R, Ebright RY, Horwitz E, Vuille JA, Hajizadeh S, Wiley DF, Reeves BA, ... ... Zou L, et al. NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer. Molecular Cell. 81: 4041-4058.e15. PMID 34624217 DOI: 10.1016/j.molcel.2021.09.016  0.568
2021 Tirman S, Quinet A, Wood M, Meroni A, Cybulla E, Jackson J, Pegoraro S, Simoneau A, Zou L, Vindigni A. Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells. Molecular Cell. 81: 4026-4040.e8. PMID 34624216 DOI: 10.1016/j.molcel.2021.09.013  0.469
2021 Simoneau A, Xiong R, Zou L. The cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells. Genes & Development. 35: 1271-1289. PMID 34385259 DOI: 10.1101/gad.348479.121  0.506
2021 Simoneau A, Zou L. An extending ATR-CHK1 circuitry: the replication stress response and beyond. Current Opinion in Genetics & Development. 71: 92-98. PMID 34329853 DOI: 10.1016/j.gde.2021.07.003  0.454
2021 Yasuhara T, Zou L. Impacts of chromatin dynamics and compartmentalization on DNA repair. Dna Repair. 105: 103162. PMID 34182258 DOI: 10.1016/j.dnarep.2021.103162  0.423
2021 Ouyang J, Yadav T, Zhang JM, Yang H, Rheinbay E, Guo H, Haber DA, Lan L, Zou L. RNA transcripts stimulate homologous recombination by forming DR-loops. Nature. PMID 33981036 DOI: 10.1038/s41586-021-03538-8  0.803
2021 Barger CJ, Chee L, Albahrani M, Munoz-Trujillo C, Boghean L, Branick C, Odunsi K, Drapkin R, Zou L, Karpf AR. Co-regulation and function of / bidirectional genes in cancer. Elife. 10. PMID 33890574 DOI: 10.7554/eLife.55070  0.371
2021 Langenbucher A, Bowen D, Sakhtemani R, Bournique E, Wise JF, Zou L, Bhagwat AS, Buisson R, Lawrence MS. An extended APOBEC3A mutation signature in cancer. Nature Communications. 12: 1602. PMID 33707442 DOI: 10.1038/s41467-021-21891-0  0.626
2021 Al Zubaidi T, Gehrisch OHF, Genois MM, Liu Q, Lu S, Kung J, Xie Y, Schuemann J, Lu HM, Hata AN, Zou L, Borgmann K, Willers H. Targeting the DNA replication stress phenotype of KRAS mutant cancer cells. Scientific Reports. 11: 3656. PMID 33574444 DOI: 10.1038/s41598-021-83142-y  0.464
2021 Zhang JM, Genois MM, Ouyang J, Lan L, Zou L. Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies. Molecular Cell. PMID 33453166 DOI: 10.1016/j.molcel.2020.12.030  0.325
2020 Genois MM, Gagné JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L. CARM1 regulates replication fork speed and stress response by stimulating PARP1. Molecular Cell. PMID 33412112 DOI: 10.1016/j.molcel.2020.12.010  0.827
2020 Chen H, Chen H, Zhang J, Wang Y, Simoneau A, Yang H, Levine AS, Zou L, Chen Z, Lan L. cGAS suppresses genomic instability as a decelerator of replication forks. Science Advances. 6. PMID 33055160 DOI: 10.1126/sciadv.abb8941  0.552
2020 Li X, Dean DC, Cote GM, Zou L, Hornicek FJ, Yu S, Duan Z. Inhibition of ATR-Chk1 signaling blocks DNA double-strand-break repair and induces cytoplasmic vacuolization in metastatic osteosarcoma. Therapeutic Advances in Medical Oncology. 12: 1758835920956900. PMID 32973933 DOI: 10.1177/1758835920956900  0.508
2020 Shin SH, Lee JS, Zhang JM, Choi S, Boskovic ZV, Zhao R, Song M, Wang R, Tian J, Lee MH, Kim JH, Jeong M, Lee JH, Petukhov M, Lee SW, ... ... Zou L, et al. Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells. Science Advances. 6: eaay9131. PMID 32789167 DOI: 10.1126/sciadv.aay9131  0.415
2020 Gupta M, Concepcion CP, Fahey CG, Keshishian H, Bhutkar A, Brainson CF, Sanchez-Rivera FJ, Pessina P, Kim JY, Simoneau A, Paschini M, Beytagh MC, Stanclift CR, Schenone M, Mani DR, ... ... Zou L, et al. BRG1 loss predisposes lung cancers to replicative stress and ATR dependency. Cancer Research. PMID 32690724 DOI: 10.1158/0008-5472.Can-20-1744  0.334
2020 Matson JP, Zou L. A genome-wide and cotranscriptional suppressor of R loops. Genes & Development. 34: 863-864. PMID 32611612 DOI: 10.1101/Gad.339861.120  0.495
2020 Vidula N, Dubash TD, Lawrence MS, Simoneau A, Niemierko A, Blouch EL, Nagy RJ, Roh W, Chirn B, Reeves B, Malvarosa G, Lennerz JK, Isakoff SJ, Juric D, Micalizzi DS, ... ... Zou L, et al. Identification of somatically acquired BRCA1/2 mutations by cfDNA analysis in patients with metastatic breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32571788 DOI: 10.1158/1078-0432.Ccr-20-0638  0.519
2020 Jalili P, Bowen D, Langenbucher A, Park S, Aguirre K, Corcoran RB, Fleischman AG, Lawrence MS, Zou L, Buisson R. Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots. Nature Communications. 11: 2971. PMID 32532990 DOI: 10.1038/S41467-020-16802-8  0.652
2020 Chen H, Yang H, Zhu X, Yadav T, Ouyang J, Truesdell SS, Tan J, Wang Y, Duan M, Wei L, Zou L, Levine AS, Vasudevan S, Lan L. mC modification of mRNA serves a DNA damage code to promote homologous recombination. Nature Communications. 11: 2834. PMID 32503981 DOI: 10.1038/S41467-020-16722-7  0.838
2020 Zhang JM, Zou L. Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks. Cell & Bioscience. 10: 30. PMID 32175073 DOI: 10.1186/S13578-020-00391-6  0.414
2019 Tan J, Duan M, Yadav T, Phoon L, Wang X, Zhang JM, Zou L, Lan L. An R-loop-initiated CSB-RAD52-POLD3 pathway suppresses ROS-induced telomeric DNA breaks. Nucleic Acids Research. PMID 31777915 DOI: 10.1093/Nar/Gkz1114  0.835
2019 Hopkins JL, Zou L. Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy. Cancer Cell. 36: 461-463. PMID 31715127 DOI: 10.1016/J.Ccell.2019.10.012  0.466
2019 Matos DA, Zhang JM, Ouyang J, Nguyen HD, Genois MM, Zou L. ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop. Molecular Cell. PMID 31708417 DOI: 10.1016/J.Molcel.2019.10.010  0.419
2019 Parmar K, Kochupurakkal BS, Lazaro JB, Wang ZC, Palakurthi S, Kirschmeier PT, Yang C, Sambel LA, Färkkilä A, Reznichenko E, Reavis HD, Dunn CE, Zou L, Do KT, Konstantinopoulos PA, et al. The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31409614 DOI: 10.1158/1078-0432.Ccr-19-0448  0.362
2019 Gross KM, Zhou W, Breindel JL, Ouyang J, Jin DX, Sokol ES, Gupta PB, Huber K, Zou L, Kuperwasser C. Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. Cell Reports. 28: 394-407.e6. PMID 31291576 DOI: 10.1016/J.Celrep.2019.06.043  0.582
2019 Ning JF, Stanciu M, Humphrey MR, Gorham J, Wakimoto H, Nishihara R, Lees J, Zou L, Martuza RL, Wakimoto H, Rabkin SD. Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. Nature Communications. 10: 2910. PMID 31266951 DOI: 10.1038/S41467-019-10993-5  0.375
2019 Buisson R, Langenbucher A, Bowen D, Kwan EE, Benes CH, Zou L, Lawrence MS. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. Science (New York, N.Y.). 364. PMID 31249028 DOI: 10.1126/Science.Aaw2872  0.563
2019 Parikh AR, He Y, Hong TS, Corcoran RB, Clark JW, Ryan DP, Zou L, Ting DT, Catenacci DV, Chao J, Fakih M, Klempner SJ, Ross JS, Frampton GM, Miller VA, et al. Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy. The Oncologist. PMID 31040255 DOI: 10.1634/Theoncologist.2019-0034  0.523
2019 Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L. Erratum: Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes & Development. 33: 253. PMID 30709902 DOI: 10.1101/gad.324053.119  0.412
2019 Ge C, Vilfranc CL, Che L, Pandita RK, Hambarde S, Andreassen PR, Niu L, Olowokure O, Shah S, Waltz SE, Zou L, Wang J, Pandita TK, Du C. The BRUCE-ATR signaling axis is required for accurate DNA replication and suppression of liver cancer development. Hepatology (Baltimore, Md.). PMID 30693543 DOI: 10.1002/Hep.30529  0.502
2019 Zhang JM, Yadav T, Ouyang J, Lan L, Zou L. Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways. Cell Reports. 26: 955-968.e3. PMID 30673617 DOI: 10.1016/J.Celrep.2018.12.102  0.836
2019 Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L. Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes & Development. 33: 75-89. PMID 30567999 DOI: 10.1101/Gad.315978.118  0.832
2018 Zou L, Nguyen HD. Getting a Genomic View of DNA Replication Stress. Molecular Cell. 72: 201-203. PMID 30340018 DOI: 10.1016/J.Molcel.2018.10.001  0.473
2018 Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, Xu J, Liang Z, Liu Y, Nakajima S, Shi Y, Levine AS, Zou L, Lan L. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nature Communications. 9: 4115. PMID 30297739 DOI: 10.1038/S41467-018-06586-3  0.805
2018 Nguyen HD, Leong WY, Li W, Reddy PNG, Sullivan JD, Walter MJ, Zou L, Graubert TA. Spliceosome Mutations Induce R loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndrome. Cancer Research. PMID 30054334 DOI: 10.1158/0008-5472.Can-17-3970  0.538
2018 Zou L. Ataxia Telangiectasia-Mutated and Rad3-Related Inhibition and Topoisomerase I Trapping Create a Synthetic Lethality in Cancer Cells. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2017771857. PMID 29369707 DOI: 10.1200/Jco.2017.77.1857  0.343
2018 Boulay G, Sandoval GJ, Riggi N, Iyer S, Buisson R, Naigles B, Awad ME, Rengarajan S, Volorio A, McBride MJ, Broye LC, Zou L, Stamenkovic I, Kadoch C, Rivera MN. Abstract PR09: Cancer-specific retargeting of BAF complexes by a prion-like domain Cancer Research. 78. DOI: 10.1158/1538-7445.Pedca17-Pr09  0.319
2017 Guarner A, Morris R, Korenjak M, Boukhali M, Zappia MP, Van Rechem C, Whetstine JR, Ramaswamy S, Zou L, Frolov MV, Haas W, Dyson NJ. E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. Developmental Cell. 43: 689-703.e5. PMID 29233476 DOI: 10.1016/J.Devcel.2017.11.008  0.494
2017 Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, Hsu PH, Zou L, Jambhekar A, He C, et al. Corrigendum: RNA m6A methylation regulates the ultraviolet-induced DNA damage response. Nature. PMID 29186122 DOI: 10.1038/Nature24007  0.501
2017 Kabeche L, Nguyen HD, Buisson R, Zou L. A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation. Science (New York, N.Y.). PMID 29170278 DOI: 10.1126/Science.Aan6490  0.519
2017 Ouyang J, Lan L, Zou L. Regulation of DNA break repair by transcription and RNA. Science China. Life Sciences. PMID 29075944 DOI: 10.1007/S11427-017-9164-1  0.542
2017 Lemaçon D, Jackson J, Quinet A, Brickner JR, Li S, Yazinski S, You Z, Ira G, Zou L, Mosammaparast N, Vindigni A. MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells. Nature Communications. 8: 860. PMID 29038425 DOI: 10.1038/S41467-017-01180-5  0.49
2017 Boulay G, Sandoval GJ, Riggi N, Iyer S, Buisson R, Naigles B, Awad ME, Rengarajan S, Volorio A, McBride MJ, Broye LC, Zou L, Stamenkovic I, Kadoch C, Rivera MN. Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. Cell. PMID 28844694 DOI: 10.1016/J.Cell.2017.07.036  0.318
2017 Buisson R, Lawrence MS, Benes CH, Zou L. APOBEC3A and 3B activities render cancer cells susceptible to ATR inhibition. Cancer Research. PMID 28698210 DOI: 10.1158/0008-5472.Can-16-3389  0.698
2017 Dubois JC, Yates M, Gaudreau-Lapierre A, Clément G, Cappadocia L, Gaudreau L, Zou L, Maréchal A. A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination. Nucleic Acids Research. PMID 28666352 DOI: 10.1093/Nar/Gkx571  0.553
2017 Okazaki A, Gameiro PA, Christodoulou D, Laviollette L, Schneider M, Chaves F, Stemmer-Rachamimov A, Yazinski SA, Lee R, Stephanopoulos G, Zou L, Iliopoulos O. Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers. The Journal of Clinical Investigation. PMID 28346230 DOI: 10.1172/Jci87800  0.392
2017 Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, Hsu PH, Zou L, Jambhekar A, He C, et al. RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response. Nature. PMID 28297716 DOI: 10.1038/Nature21671  0.6
2017 Nguyen HD, Yadav T, Giri S, Saez B, Graubert TA, Zou L. Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1. Molecular Cell. 65: 832-847.e4. PMID 28257700 DOI: 10.1016/J.Molcel.2017.01.029  0.814
2017 Yazinski SA, Comaills V, Buisson R, Genois MM, Nguyen HD, Ho CK, Todorova Kwan T, Morris R, Lauffer S, Nussenzweig A, Ramaswamy S, Benes CH, Haber DA, Maheswaran S, Birrer MJ, ... Zou L, et al. ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells. Genes & Development. PMID 28242626 DOI: 10.1101/Gad.290957.116  0.399
2017 Zou L. DNA Replication Checkpoint: New ATR Activator Identified. Current Biology : Cb. 27: R33-R35. PMID 28073021 DOI: 10.1016/J.Cub.2016.11.025  0.508
2017 Leong WY, Nguyen HD, Li W, Walter MJ, Zou L, Graubert TA. Spliceosomal Mutations Induce R Loop-Associated ATR Signaling Blood. 130: 116-116. DOI: 10.1182/Blood.V130.Suppl_1.116.116  0.46
2017 Buisson R, Joshi N, Ho CK, Rodrigue A, Foo TK, Hardy E, Haas W, Xia B, Masson J, Zou L. Abstract MIP-049: ATR–DEPENDENT REGULATION OF THE OVARIAN CANCER PROTEIN PALB2 AT DNA DOUBLE–STRAND BREAKS Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Ovcasymp16-Mip-049  0.584
2017 Couturier A, Buisson R, Pauty J, Rodrigue A, Joshi N, Caron M, Coulombe Y, Zou L, Masson J. Abstract PR01: Mechanisms of regulation of the tumor suppressor PALB2 Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-Pr01  0.507
2017 Dubois J, Clément G, Cappadocia L, Gaudreau L, Zou L, Maréchal A. Abstract A04: Phosphorylation and ubiquitylation on the RPA-ssDNA platform promote homologous recombination Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-A04  0.578
2017 Couturier AM, Buisson R, Pauty J, Rodrigue A, Caron M, Coulombe Y, Joshi N, Zou L, Masson J. Abstract B18: Mechanisms of regulation and synthetic lethal strategies against PALB2 and APRIN, two DNA double-strand break repair proteins Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-B18  0.534
2017 Zou L. Abstract MS2-1: MS2-1 Targeting the ATR checkpoint in cancer therapy Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-Ms2-1  0.466
2016 Buisson R, Niraj J, Rodrigue A, Ho CK, Kreuzer J, Foo TK, Hardy EJ, Dellaire G, Haas W, Xia B, Masson JY, Zou L. Coupling of Homologous Recombination and the Checkpoint by ATR. Molecular Cell. PMID 28089683 DOI: 10.1016/J.Molcel.2016.12.007  0.547
2016 Zou L. A Zygotic Checkpoint for Unrepaired Lesions. Cell. 167: 1676-1678. PMID 27984718 DOI: 10.1016/J.Cell.2016.11.049  0.531
2016 Comaills V, Kabeche L, Morris R, Buisson R, Yu M, Madden MW, LiCausi JA, Boukhali M, Tajima K, Pan S, Aceto N, Sil S, Zheng Y, Sundaresan T, Yae T, ... ... Zou L, et al. Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition. Cell Reports. 17: 2632-2647. PMID 27926867 DOI: 10.1016/J.Celrep.2016.11.022  0.356
2016 Yazinski SA, Zou L. Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway. Annual Review of Genetics. PMID 27617969 DOI: 10.1146/Annurev-Genet-121415-121658  0.598
2015 Zou L, Li L. The 2015 Albert Lasker basic medical research award: An exhilarating journey to the DNA damage checkpoint. Science China. Life Sciences. PMID 26668018 DOI: 10.1007/S11427-015-4984-3  0.555
2015 Wang Z, Dai X, Zhong J, Inuzuka H, Wan L, Li X, Wang L, Ye X, Sun L, Gao D, Zou L, Wei W. SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation. Nature Communications. 6: 10185. PMID 26666832 DOI: 10.1038/Ncomms10185  0.442
2015 Wu CS, Zou L. The SUMO Ligase PIAS3 Primes ATR for Checkpoint Activation. The Journal of Biological Chemistry. PMID 26565033 DOI: 10.1074/Jbc.M115.691170  0.599
2015 Buisson R, Boisvert JL, Benes CH, Zou L. Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase. Molecular Cell. 59: 1011-24. PMID 26365377 DOI: 10.1016/J.Molcel.2015.07.029  0.527
2015 Karnitz LM, Zou L. Molecular Pathways: Targeting ATR in Cancer Therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 4780-5. PMID 26362996 DOI: 10.1158/1078-0432.Ccr-15-0479  0.54
2015 Gong C, Liu B, Yao Y, Qu S, Luo W, Tan W, Liu Q, Yao H, Zou L, Su F, Song E. Potentiated DNA Damage Response in Circulating Breast Tumor Cells Confers Resistance to Chemotherapy. The Journal of Biological Chemistry. 290: 14811-25. PMID 25897074 DOI: 10.1074/Jbc.M115.652628  0.493
2015 Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, Haber DA, Boussin FD, Zou L. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science (New York, N.Y.). 347: 273-7. PMID 25593184 DOI: 10.1126/Science.1257216  0.476
2015 Ouyang J, Garner E, Hallet A, Nguyen HD, Rickman KA, Gill G, Smogorzewska A, Zou L. Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance. Molecular Cell. 57: 108-22. PMID 25533185 DOI: 10.1016/J.Molcel.2014.11.015  0.765
2015 Maréchal A, Zou L. RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Research. 25: 9-23. PMID 25403473 DOI: 10.1038/Cr.2014.147  0.618
2014 Maréchal A, Zou L. A LARGe surprise links ATR and Rho. Cell Cycle (Georgetown, Tex.). 13: 3627. PMID 25551359 DOI: 10.4161/15384101.2014.980705  0.563
2014 Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B. The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. Cell Reports. 8: 807-17. PMID 25066119 DOI: 10.1016/J.Celrep.2014.06.050  0.365
2014 Wu CS, Ouyang J, Mori E, Nguyen HD, Maréchal A, Hallet A, Chen DJ, Zou L. SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Genes & Development. 28: 1472-84. PMID 24990965 DOI: 10.1101/Gad.238535.114  0.498
2014 Manning AL, Yazinski SA, Nicolay B, Bryll A, Zou L, Dyson NJ. Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion. Molecular Cell. 53: 993-1004. PMID 24613344 DOI: 10.1016/J.Molcel.2014.01.032  0.413
2014 Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Molecular Cell. 53: 235-46. PMID 24332808 DOI: 10.1016/J.Molcel.2013.11.002  0.602
2013 Maréchal A, Zou L. DNA damage sensing by the ATM and ATR kinases Cold Spring Harbor Perspectives in Biology. 5. PMID 24003211 DOI: 10.1101/Cshperspect.A012716  0.615
2013 Pfäffle HN, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes CH, Sequist LV, Zou L, Willers H. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity. Cancer Research. 73: 6254-63. PMID 23966292 DOI: 10.1158/0008-5472.Can-13-0044  0.417
2013 Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T. Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor. Carcinogenesis. 34: 2486-97. PMID 23825154 DOI: 10.1093/Carcin/Bgt240  0.576
2013 Shiotani B, Nguyen HD, Håkansson P, Maréchal A, Tse A, Tahara H, Zou L. Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. Cell Reports. 3: 1651-62. PMID 23684611 DOI: 10.1016/J.Celrep.2013.04.018  0.522
2013 Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H. Detection of impaired homologous recombination repair in NSCLC cells and tissues. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 8: 279-86. PMID 23399959 DOI: 10.1097/Jto.0B013E31827Ecf83  0.532
2013 Zou L. Four pillars of the S-phase checkpoint Genes and Development. 27: 227-233. PMID 23388823 DOI: 10.1101/Gad.213306.113  0.466
2013 Liu S, Ho CK, Ouyang J, Zou L. Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 2175-80. PMID 23345434 DOI: 10.1073/Pnas.1217781110  0.538
2012 Liu S, Song N, Zou L. The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1. Cell Cycle (Georgetown, Tex.). 11: 2711-6. PMID 22732499 DOI: 10.4161/Cc.21041  0.43
2012 Centore RC, Yazinski SA, Tse A, Zou L. Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. Molecular Cell. 46: 625-35. PMID 22681887 DOI: 10.1016/J.Molcel.2012.05.020  0.599
2012 Flynn RL, Chang S, Zou L. RPA and POT1: friends or foes at telomeres? Cell Cycle (Georgetown, Tex.). 11: 652-7. PMID 22373525 DOI: 10.4161/Cc.11.4.19061  0.554
2012 Havens CG, Shobnam N, Guarino E, Centore RC, Zou L, Kearsey SE, Walter JC. Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2. The Journal of Biological Chemistry. 287: 11410-21. PMID 22303007 DOI: 10.1074/Jbc.M111.337683  0.361
2012 Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, Vivanco MD, Haber DA, Zou L, Maheswaran S. Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses. Proceedings of the National Academy of Sciences of the United States of America. 109: 2760-5. PMID 21930940 DOI: 10.1073/Pnas.1018867108  0.563
2012 Willers H, Birkelbach M, Ferraiolo N, Gheorghiu L, Pfaeffle H, Daly B, Dahm-Daphi J, Benes C, Zou L, Kachnic L. Recombinational DNA Repair Defects in Lung Cancer and PARP Inhibitor Sensitivity International Journal of Radiation Oncology*Biology*Physics. 84: S126-S127. DOI: 10.1016/J.Ijrobp.2012.07.129  0.478
2011 Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K. NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis. Molecular Cell. 43: 788-97. PMID 21884979 DOI: 10.1016/J.Molcel.2011.07.026  0.576
2011 Shiotani B, Zou L. A human cell extract-based assay for the activation of ATM and ATR checkpoint kinases. Methods in Molecular Biology (Clifton, N.J.). 782: 181-91. PMID 21870292 DOI: 10.1007/978-1-61779-273-1_13  0.576
2011 Sirbu BM, Lachmayer SJ, Wülfing V, Marten LM, Clarkson KE, Lee LW, Gheorghiu L, Zou L, Powell SN, Dahm-Daphi J, Willers H. ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells. Plos One. 6: e23053. PMID 21857991 DOI: 10.1371/Journal.Pone.0023053  0.511
2011 Liu S, Shiotani B, Lahiri M, Maréchal A, Tse A, Leung CC, Glover JN, Yang XH, Zou L. ATR autophosphorylation as a molecular switch for checkpoint activation. Molecular Cell. 43: 192-202. PMID 21777809 DOI: 10.1016/J.Molcel.2011.06.019  0.628
2011 Flynn RL, Centore RC, O'Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, Zou L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature. 471: 532-6. PMID 21399625 DOI: 10.1038/Nature09772  0.544
2011 Nakamura K, Kato A, Kobayashi J, Yanagihara H, Sakamoto S, Oliveira DV, Shimada M, Tauchi H, Suzuki H, Tashiro S, Zou L, Komatsu K. Regulation of homologous recombination by RNF20-dependent H2B ubiquitination. Molecular Cell. 41: 515-28. PMID 21362548 DOI: 10.1016/J.Molcel.2011.02.002  0.514
2011 Flynn RL, Zou L. ATR: A master conductor of cellular responses to DNA replication stress Trends in Biochemical Sciences. 36: 133-140. PMID 20947357 DOI: 10.1016/J.Tibs.2010.09.005  0.616
2011 Liu Q, Zhou D, Shiotani B, Gray NS, Elledge SJ, Zou L. Abstract 1358: Discovery and optimization of potent and selective benzonaphthyridinone analogs as dual mTOR/ATR small molecular inhibitors for treatment of cancer Cancer Research. 71: 1358-1358. DOI: 10.1158/1538-7445.Am2011-1358  0.637
2010 Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L. CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Molecular Cell. 40: 22-33. PMID 20932472 DOI: 10.1016/J.Molcel.2010.09.015  0.468
2010 Zou L. DNA repair: A protein giant in its entirety Nature. 467: 667-668. PMID 20930833 DOI: 10.1038/467667A  0.524
2010 Huang M, Kim JM, Shiotani B, Yang K, Zou L, D'Andrea AD. The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Molecular Cell. 39: 259-68. PMID 20670894 DOI: 10.1016/J.Molcel.2010.07.005  0.598
2010 Flynn RL, Zou L. Oligonucleotide/oligosaccharide-binding fold proteins: A growing family of genome guardians Critical Reviews in Biochemistry and Molecular Biology. 45: 266-275. PMID 20515430 DOI: 10.3109/10409238.2010.488216  0.607
2009 Zou L. Checkpoint Mec-tivation Comes in Many Flavors Molecular Cell. 36: 734-735. PMID 20005837 DOI: 10.1016/J.Molcel.2009.11.026  0.433
2009 Zhang J, Song YH, Brannigan BW, Wahrer DC, Schiripo TA, Harris PL, Haserlat SM, Ulkus LE, Shannon KM, Garber JE, Freedman ML, Henderson BE, Zou L, Sgroi DC, Haber DA, et al. Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin. Molecular Cancer Research : McR. 7: 1510-6. PMID 19737971 DOI: 10.1158/1541-7786.Mcr-09-0033  0.447
2009 Shiotani B, Zou L. Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks Molecular Cell. 33: 547-558. PMID 19285939 DOI: 10.1016/J.Molcel.2009.01.024  0.573
2009 Yang XH, Zou L. Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination. Cell Cycle (Georgetown, Tex.). 8: 191-4. PMID 19158510 DOI: 10.4161/Cc.8.2.7357  0.714
2009 Gonzalez-Malerva L, Park J, Zou L, Hu Y, Moradpour Z, Pearlberg J, Harlow E, LaBaer J. Autophagy and Tamoxifen Resistance in Breast Cancer. Cancer Research. 69: 5135-5135. DOI: 10.1158/0008-5472.Sabcs-09-5135  0.301
2008 Yang XH, Shiotani B, Classon M, Zou L. Chk1 and Claspin potentiate PCNA ubiquitination. Genes & Development. 22: 1147-52. PMID 18451105 DOI: 10.1101/Gad.1632808  0.713
2007 Yang XH, Zou L. Launching a ubiquitination cascade at DNA breaks. Proceedings of the National Academy of Sciences of the United States of America. 104: 20645-6. PMID 18093907 DOI: 10.1073/Pnas.0710916105  0.631
2007 Zou L. Single- and double-stranded DNA: Building a trigger of ATR-mediated DNA damage response Genes and Development. 21: 879-885. PMID 17437994 DOI: 10.1101/Gad.1550307  0.628
2006 Yang XH, Zou L. Checkpoint and coordinated cellular responses to DNA damage. Results and Problems in Cell Differentiation. 42: 65-92. PMID 16903208  0.657
2006 Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L. Rad17 Phosphorylation Is Required for Claspin Recruitment and Chk1 Activation in Response to Replication Stress Molecular Cell. 23: 331-341. PMID 16885023 DOI: 10.1016/J.Molcel.2006.06.022  0.586
2006 Yang XH, Zou L. Recruitment of ATR-ATRIP, Rad17, and 9-1-1 Complexes to DNA Damage Methods in Enzymology. 409: 118-131. PMID 16793398 DOI: 10.1016/S0076-6879(05)09007-5  0.708
2006 Namiki Y, Zou L. ATRIP associates with replication protein A-coated ssDNA through multiple interactions. Proceedings of the National Academy of Sciences of the United States of America. 103: 580-5. PMID 16407120 DOI: 10.1073/Pnas.0510223103  0.507
2005 Li L, Zou L. Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells Journal of Cellular Biochemistry. 94: 298-306. PMID 15578575 DOI: 10.1002/Jcb.20355  0.61
2003 Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 complexes Proceedings of the National Academy of Sciences of the United States of America. 100: 13827-13832. PMID 14605214 DOI: 10.1073/Pnas.2336100100  0.704
2003 Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes Science. 300: 1542-1548. PMID 12791985 DOI: 10.1126/Science.1083430  0.717
2003 Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L. Genomic instability and endoreduplication triggered by RAD17 deletion Genes and Development. 17: 965-970. PMID 12672690 DOI: 10.1101/Gad.1065103  0.628
2002 Osborn AJ, Elledge SJ, Zou L. Checking on the fork: The DNA-replication stress-response pathway Trends in Cell Biology. 12: 509-516. PMID 12446112 DOI: 10.1016/S0962-8924(02)02380-2  0.718
2002 Zou L, Cortez D, Elledge SJ. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin Genes and Development. 16: 198-208. PMID 11799063 DOI: 10.1101/Gad.950302  0.775
Show low-probability matches.