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Christopher S. Chen - Publications

Affiliations: 
Bioengineering University of Pennsylvania, Philadelphia, PA, United States 
 Biomedical Engineering Boston University, Boston, MA, United States 
 Wyss Insitute Harvard University, Cambridge, MA, United States 
Area:
Tissue Microfabrication
Website:
https://sites.bu.edu/chenlab/
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284 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT, Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS. A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex. Proceedings of the National Academy of Sciences of the United States of America. 120: e2308941120. PMID 37782785 DOI: 10.1073/pnas.2308941120  0.805
2023 Griebel M, Vasan A, Chen C, Eyckmans J. Fibroblast clearance of damaged tissue following laser ablation in engineered microtissues. Apl Bioengineering. 7: 016112. PMID 36938481 DOI: 10.1063/5.0133478  0.78
2023 Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A. Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling. International Journal of Molecular Sciences. 24. PMID 36902152 DOI: 10.3390/ijms24054724  0.788
2023 Paul I, Bolzan D, Youssef A, Gagnon KA, Hook H, Karemore G, Oliphant MUJ, Lin W, Liu Q, Phanse S, White C, Padhorny D, Kotelnikov S, Chen CS, Hu P, et al. Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT. Nature Communications. 14: 688. PMID 36755019 DOI: 10.1038/s41467-023-36122-x  0.664
2022 Das SL, Sutherland BP, Lejeune E, Eyckmans J, Chen CS. Mechanical response of cardiac microtissues to acute localized injury. American Journal of Physiology. Heart and Circulatory Physiology. 323: H738-H748. PMID 36053751 DOI: 10.1152/ajpheart.00305.2022  0.795
2022 Michas C, Karakan MÇ, Nautiyal P, Seidman JG, Seidman CE, Agarwal A, Ekinci K, Eyckmans J, White AE, Chen CS. Engineering a living cardiac pump on a chip using high-precision fabrication. Science Advances. 8: eabm3791. PMID 35452278 DOI: 10.1126/sciadv.abm3791  0.703
2021 Tefft JB, Bays JL, Lammers A, Kim S, Eyckmans J, Chen CS. Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature. American Journal of Physiology. Cell Physiology. PMID 34878922 DOI: 10.1152/ajpcell.00320.2021  0.787
2021 Zhang K, Cloonan PE, Sundaram S, Liu F, Das SL, Ewoldt JK, Bays JL, Tomp S, Toepfer CN, Marsiglia JDC, Gorham J, Reichart D, Eyckmans J, Seidman JG, Seidman CE, ... Chen CS, et al. Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Science Advances. 7: eabh3995. PMID 34652945 DOI: 10.1126/sciadv.abh3995  0.762
2021 Zhao B, Zhang K, Chen CS, Lejeune E. Sarc-Graph: Automated segmentation, tracking, and analysis of sarcomeres in hiPSC-derived cardiomyocytes. Plos Computational Biology. 17: e1009443. PMID 34613960 DOI: 10.1371/journal.pcbi.1009443  0.68
2021 Javor J, Ewoldt JK, Cloonan PE, Chopra A, Luu RJ, Freychet G, Zhernenkov M, Ludwig K, Seidman JG, Seidman CE, Chen CS, Bishop DJ. Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue. Microsystems & Nanoengineering. 7: 10. PMID 34567727 DOI: 10.1038/s41378-020-00234-x  0.791
2021 Agarwal R, Paulo J, Toepfer CN, Ewoldt JK, Sundaram S, Chopra A, Zhang Q, Gorham J, DePalma S, Chen CS, Gygi S, Seidman CE, Seidman JG. Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation. Circulation Research. PMID 34405687 DOI: 10.1161/CIRCRESAHA.120.317076  0.781
2021 Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, et al. SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway. Journal of Virology. JVI0086221. PMID 34260266 DOI: 10.1128/JVI.00862-21  0.793
2021 Das SL, Bose P, Lejeune E, Reich DH, Chen C, Eyckmans J. Extracellular Matrix Alignment Directs Provisional Matrix Assembly and Three Dimensional Fibrous Tissue Closure. Tissue Engineering. Part A. PMID 33979548 DOI: 10.1089/ten.tea.2020.0332  0.796
2021 Jayne RK, Karakan MÇ, Zhang K, Pierce N, Michas C, Bishop DJ, Chen CS, Ekinci KL, White AE. Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers. Lab On a Chip. 21: 1724-1737. PMID 33949395 DOI: 10.1039/d0lc01078b  0.796
2021 Tsang JM, Gritton HJ, Das SL, Weber TD, Chen CS, Han X, Mertz J. Fast, multiplane line-scan confocal microscopy using axially distributed slits. Biomedical Optics Express. 12: 1339-1350. PMID 33796357 DOI: 10.1364/BOE.417286  0.767
2021 Song J, Michas C, Chen CS, White AE, Grinstaff MW. Controlled Cell Alignment Using Two-Photon Direct Laser Writing-Patterned Hydrogels in 2D and 3D. Macromolecular Bioscience. e2100051. PMID 33738917 DOI: 10.1002/mabi.202100051  0.734
2021 Kostecki GM, Shi Y, Chen CS, Reich DH, Entcheva E, Tung L. Optogenetic current in myofibroblasts acutely alters electrophysiology and conduction of co-cultured cardiomyocytes. Scientific Reports. 11: 4430. PMID 33627695 DOI: 10.1038/s41598-021-83398-4  0.517
2021 Ward TL, Tai W, Morton SU, Impens F, VanDamme P, Van Haver D, Timmerman E, Venturini G, Zhang K, Jang MY, Willcox JA, Haghighi A, Gelb BD, Chung WK, Goldmuntz E, ... ... Chen CS, et al. Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency. Circulation Research. PMID 33557580 DOI: 10.1161/CIRCRESAHA.120.316966  0.705
2021 Tefft JB, Chen CS, Eyckmans J. Reconstituting the dynamics of endothelial cells and fibroblasts in wound closure. Apl Bioengineering. 5: 016102. PMID 33511324 DOI: 10.1063/5.0028651  0.781
2020 Chen AX, Chhabra A, Song HG, Fleming HE, Chen CS, Bhatia SN. Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers. Advanced Functional Materials. 30. PMID 33776613 DOI: 10.1002/Adfm.201910442  0.409
2020 Song HG, Lammers A, Sundaram S, Rubio L, Chen AX, Li L, Eyckmans J, Bhatia SN, Chen CS. Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues. Advanced Functional Materials. 30. PMID 33613149 DOI: 10.1002/Adfm.202003777  0.82
2020 Chen D, Smith LR, Khandekar G, Patel P, Yu CK, Zhang K, Chen CS, Han L, Wells RG. Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization. Scientific Reports. 10: 19065. PMID 33149218 DOI: 10.1038/s41598-020-76107-0  0.796
2020 Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, et al. SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. Biorxiv : the Preprint Server For Biology. PMID 33140044 DOI: 10.1101/2020.10.27.358259  0.789
2020 Pua CJ, Tham N, Chin CW, Walsh R, Khor CC, Toepfer CN, Repetti GG, Garfinkel AC, Ewoldt JF, Cloonan P, Chen CS, Lim SQ, Cai J, Loo LY, Kong SC, et al. Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in and that Are Common in Chinese Patients. Circulation. Genomic and Precision Medicine. PMID 32815737 DOI: 10.1161/CIRCGEN.119.002823  0.759
2020 Kutys ML, Polacheck WJ, Welch MK, Gagnon KA, Koorman T, Kim S, Li L, McClatchey AI, Chen CS. Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Nature Communications. 11: 3377. PMID 32632100 DOI: 10.1038/S41467-020-17102-X  0.696
2020 Song D, Dong L, Gupta M, Li L, Klaas O, Loghin A, Beall M, Chen C, Oberai AA. Recovery of Tractions Exerted by Singe Cells in 3D Nonlinear Matrices. Journal of Biomechanical Engineering. PMID 32320015 DOI: 10.1115/1.4046974  0.354
2020 Shroff SN, Das SL, Tseng HA, Noueihed J, Fernandez F, White JA, Chen CS, Han X. Voltage Imaging of Cardiac Cells and Tissue Using the Genetically Encoded Voltage Sensor Archon1. Iscience. 23: 100974. PMID 32299055 DOI: 10.1016/J.Isci.2020.100974  0.794
2020 Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature. PMID 32051585 DOI: 10.1038/S41586-020-1998-1  0.407
2020 Toepfer CN, Garfinkel AC, Venturini G, Wakimoto H, Repetti G, Alamo L, Sharma A, Agarwal R, Ewoldt JF, Cloonan P, Letendre J, Lun M, Olivotto I, Colan S, Ashley E, ... ... Chen CS, et al. Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy. Circulation. PMID 31983222 DOI: 10.1161/Circulationaha.119.042339  0.775
2019 Bose P, Eyckmans J, Nguyen TD, Chen CS, Reich DH. Effects of Geometry on the Mechanics and Alignment of Three-Dimensional Engineered Microtissues. Acs Biomaterials Science & Engineering. 5: 3843-3855. PMID 33438424 DOI: 10.1021/Acsbiomaterials.8B01183  0.621
2019 Song J, Michas C, Chen CS, White AE, Grinstaff MW. From Simple to Architecturally Complex Hydrogel Scaffolds for Cell and Tissue Engineering Applications: Opportunities Presented by Two-Photon Polymerization. Advanced Healthcare Materials. e1901217. PMID 31746140 DOI: 10.1002/Adhm.201901217  0.729
2019 Nguyen DT, Lee E, Alimperti S, Norgard RJ, Wong A, Lee JJ, Eyckmans J, Stanger BZ, Chen CS. A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling. Science Advances. 5: eaav6789. PMID 31489365 DOI: 10.1126/Sciadv.Aav6789  0.794
2019 Du Y, Khandekar G, Llewellyn J, Polacheck W, Chen CS, Wells RG. A Bile Duct-on-a-Chip with Organ-Level Functions. Hepatology (Baltimore, Md.). PMID 31465556 DOI: 10.1002/Hep.30918  0.311
2019 Cardenas-Diaz FL, Osorio-Quintero C, Diaz-Miranda MA, Kishore S, Leavens K, Jobaliya C, Stanescu D, Ortiz-Gonzalez X, Yoon C, Chen CS, Haliyur R, Brissova M, Powers AC, French DL, Gadue P. Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A. Cell Stem Cell. 25: 273-289.e5. PMID 31374199 DOI: 10.1016/J.Stem.2019.07.007  0.78
2019 Li S, Chopra A, Keung W, Chan C, Costa KD, Kong CW, Hajjar RJ, Chen C, Li R. Sarco/Endoplasmic Reticulum Ca-ATPase is a more effective calcium remover than Sodium-Calcium Exchanger in human embryonic stem cell-derived cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. PMID 31347915 DOI: 10.1152/Ajpheart.00540.2018  0.727
2019 Yoon C, Choi C, Stapleton S, Mirabella T, Howes C, Dong L, King J, Yang J, Oberai A, Eyckmans J, Chen CS. Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting. Molecular Biology of the Cell. mbcE19020076. PMID 31318321 DOI: 10.1091/Mbc.E19-02-0076  0.833
2019 Chow MZ, Sadrian SN, Keung W, Geng L, Ren L, Kong CW, Wong AO, Hulot JS, Chen CS, Costa KD, Hajjar RJ, Li RA. Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues. Scientific Reports. 9: 7502. PMID 31097748 DOI: 10.1038/S41598-019-42953-W  0.387
2019 Polacheck WJ, Kutys ML, Tefft JB, Chen CS. Microfabricated blood vessels for modeling the vascular transport barrier. Nature Protocols. PMID 30953042 DOI: 10.1038/S41596-019-0144-8  0.778
2019 Cheng D, Jayne RK, Tamborini A, Eyckmans J, White AE, Chen CS. Studies of 3D directed cell migration enabled by direct laser writing of curved wave topography. Biofabrication. PMID 30721899 DOI: 10.1088/1758-5090/Ab047F  0.752
2019 Toepfer CN, Sharma A, Cicconet M, Garfinkel AC, Mücke M, Neyazi M, Willcox JA, Agarwal R, Schmid M, Rao J, Ewoldt JK, Pourquié O, Chopra A, Chen C, Seidman JG, et al. SarcTrack: An Adaptable Software Tool for Efficient Large-Scale Analysis of Sarcomere Function in hiPSC-Cardiomyocytes. Circulation Research. PMID 30700234 DOI: 10.1161/Circresaha.118.314505  0.796
2019 Zhang K, Tomp S, Ewoldt JK, Toepfer CN, Chopra A, Seidman CE, Seidman JG, Chen CS. Abstract 482: Modeling PKP2 Mutation Associated Arrhythmogenic Cardiomyopathy With CRISPR-edited iPSC-derived Cardiomyocytes in Engineered Cardiac Tissues Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.482  0.78
2019 Das S, Shroff S, Tseng H, Chopra A, Han X, Chen C. Abstract 462: High Speed Imaging of Single Cardiomyocyte Action Potentials Using a Far-red Genetically Encoded Voltage Sensor Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.462  0.755
2019 Michas C, Nautiyal P, Agarwal A, White AE, Chen CS. Abstract 417: A 3D iPSC-derived Scaffold-Assisted Microfluidic Model of Ventricular Ejection Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.417  0.699
2019 Toepfer C, Sharma A, Garfinkel A, Cicconet M, Agarwal R, Chopra A, Chen C, Seidman J, Seidman C. Abstract 341: Efficient Large-scale Sarcomere Tracking (sarctrack) to Assess HCM Variants in iPSC-CMs Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.341  0.698
2019 Kai F, Ou G, Long A, Guo W, Tourdot R, Radhakrishnan R, Chen C, Dumont S, Weaver VM. Abstract 1028: Extracellular matrix dimensionality reduces cellular cortical tension to stimulate pro-survival signaling in mammary epithelial cells Cancer Research. 79: 1028-1028. DOI: 10.1158/1538-7445.Am2019-1028  0.395
2018 Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, Chen CS. Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. Apl Bioengineering. 2: 046107. PMID 31069329 DOI: 10.1063/1.5052239  0.332
2018 Hassell BA, Goyal G, Lee E, Sontheimer-Phelps A, Levy O, Chen CS, Ingber DE. Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro. Cell Reports. 23: 3698. PMID 29925009 DOI: 10.1016/j.celrep.2018.06.028  0.766
2018 Benhamouche-Trouillet S, O'Loughlin E, Liu CH, Polacheck W, Fitamant J, McKee M, El-Bardeesy N, Chen CS, McClatchey AI. Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis. Development (Cambridge, England). 145. PMID 29712669 DOI: 10.1242/Dev.162123  0.308
2018 Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, ... ... Chen CS, et al. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and HS Production. Cell. 173: 117-129.e14. PMID 29570992 DOI: 10.1016/J.Cell.2018.03.001  0.304
2018 Song HG, Rumma RT, Ozaki CK, Edelman ER, Chen CS. Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise. Cell Stem Cell. 22: 340-354. PMID 29499152 DOI: 10.1016/J.Stem.2018.02.009  0.349
2018 von Erlach TC, Bertazzo S, Wozniak MA, Horejs CM, Maynard SA, Attwood S, Robinson BK, Autefage H, Kallepitis C, Del Río Hernández A, Chen CS, Goldoni S, Stevens MM. Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate. Nature Materials. PMID 29434303 DOI: 10.1038/S41563-017-0014-0  0.394
2018 Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Developmental Cell. 44: 87-96.e5. PMID 29316444 DOI: 10.1016/J.Devcel.2017.12.012  0.792
2018 Bose P, Huang CY, Eyckmans J, Chen CS, Reich DH. Fabrication and Mechanical Properties Measurements of 3D Microtissues for the Study of Cell-Matrix Interactions. Methods in Molecular Biology (Clifton, N.J.). 1722: 303-328. PMID 29264812 DOI: 10.1007/978-1-4939-7553-2_18  0.332
2018 Bose P, Huang CY, Eyckmans J, Chen CS, Reich DH. Fabrication and Mechanical Properties Measurements of 3D Microtissues for the Study of Cell-Matrix Interactions. Methods in Molecular Biology (Clifton, N.J.). 1722: 303-328. PMID 29264812 DOI: 10.1007/978-1-4939-7553-2_18  0.667
2017 Mirabella T, MacArthur JW, Cheng D, Ozaki CK, Woo YJ, Yang M, Chen CS. 3D-printed vascular networks direct therapeutic angiogenesis in ischaemia. Nature Biomedical Engineering. 1. PMID 29515935 DOI: 10.1038/S41551-017-0083  0.332
2017 Li L, Eyckmans J, Chen CS. Designer biomaterials for mechanobiology. Nature Materials. 16: 1164-1168. PMID 29170549 DOI: 10.1038/Nmat5049  0.334
2017 Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. PMID 29160307 DOI: 10.1038/Nature24998  0.336
2017 Chen CS. Forces as regulators of cell adhesions. Nature Reviews. Molecular Cell Biology. PMID 29093558 DOI: 10.1038/Nrm.2017.112  0.355
2017 Hassell BA, Goyal G, Lee E, Sontheimer-Phelps A, Levy O, Chen CS, Ingber DE. Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro. Cell Reports. 21: 508-516. PMID 29020635 DOI: 10.1016/J.Celrep.2017.09.043  0.785
2017 Trappmann B, Baker BM, Polacheck WJ, Choi CK, Burdick JA, Chen CS. Matrix degradability controls multicellularity of 3D cell migration. Nature Communications. 8: 371. PMID 28851858 DOI: 10.1038/S41467-017-00418-6  0.435
2017 Alimperti S, Mirabella T, Bajaj V, Polacheck W, Pirone DM, Duffield J, Eyckmans J, Assoian RK, Chen CS. Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function. Proceedings of the National Academy of Sciences of the United States of America. PMID 28765370 DOI: 10.1073/Pnas.1618333114  0.413
2017 Stevens KR, Scull MA, Ramanan V, Fortin CL, Chaturvedi RR, Knouse KA, Xiao JW, Fung C, Mirabella T, Chen AX, McCue MG, Yang MT, Fleming HE, Chung K, de Jong YP, ... Chen CS, et al. In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease. Science Translational Medicine. 9. PMID 28724577 DOI: 10.1126/Scitranslmed.Aah5505  0.793
2017 Dang LTH, Aburatani T, Marsh GA, Johnson BG, Alimperti S, Yoon CJ, Huang A, Szak S, Nakagawa N, Gomez I, Ren S, Read SK, Sparages C, Aplin AC, Nicosia RF, ... Chen C, et al. Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury. Biomaterials. 141: 314-329. PMID 28711779 DOI: 10.1016/J.Biomaterials.2017.07.010  0.809
2017 Bendell AC, Williamson EK, Chen CS, Burkhardt JK, Hammer DA. The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28678266 DOI: 10.1039/C7Ib00070G  0.325
2017 Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, ... Chen CS, et al. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Reports. 19: 2410. PMID 28614725 DOI: 10.1016/j.celrep.2017.05.038  0.765
2017 Cao X, Ban E, Baker BM, Lin Y, Burdick JA, Chen CS, Shenoy VB. Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices. Proceedings of the National Academy of Sciences of the United States of America. PMID 28468803 DOI: 10.1073/Pnas.1620486114  0.363
2017 Nguyen DT, Gao L, Wong A, Chen CS. Cdc42 regulates branching in angiogenic sprouting in vitro. Microcirculation (New York, N.Y. : 1994). PMID 28376260 DOI: 10.1111/Micc.12372  0.731
2017 Shaya O, Binshtok U, Hersch M, Rivkin D, Weinreb S, Amir-Zilberstein L, Khamaisi B, Oppenheim O, Desai RA, Goodyear RJ, Richardson GP, Chen CS, Sprinzak D. Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning. Developmental Cell. 40: 505-511.e6. PMID 28292428 DOI: 10.1016/J.Devcel.2017.02.009  0.64
2017 Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, et al. Laminar flow downregulates Notch activity to promote lymphatic sprouting. The Journal of Clinical Investigation. PMID 28263185 DOI: 10.1172/Jci87442  0.791
2016 Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, et al. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Reports. 17: 3292-3304. PMID 28009297 DOI: 10.1016/J.Celrep.2016.11.066  0.783
2016 Eyckmans J, Chen CS. 3D culture models of tissues under tension. Journal of Cell Science. PMID 27909243 DOI: 10.1242/Jcs.198630  0.415
2016 Heo SJ, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA, Mauck RL. Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. Elife. 5. PMID 27901466 DOI: 10.7554/Elife.18207  0.535
2016 Keung W, Ren L, Sen Li, Wong AO, Chopra A, Kong CW, Tomaselli GF, Chen CS, Li RA. Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels. Scientific Reports. 6: 34154. PMID 27677332 DOI: 10.1038/Srep34154  0.744
2016 Liu AS, Wang H, Copeland CR, Chen CS, Shenoy VB, Reich DH. Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling. Scientific Reports. 6: 33919. PMID 27671239 DOI: 10.1038/Srep33919  0.646
2016 Chen CS. 3D Biomimetic Cultures: The Next Platform for Cell Biology. Trends in Cell Biology. PMID 27637342 DOI: 10.1016/J.Tcb.2016.08.008  0.338
2016 Lee E, Song HG, Chen CS. Biomimetic on-a-chip platforms for studying cancer metastasis. Current Opinion in Chemical Engineering. 11: 20-27. PMID 27570735 DOI: 10.1016/J.Coche.2015.12.001  0.774
2016 Foolen J, Shiu JY, Mitsi M, Zhang Y, Chen CS, Vogel V. Full-Length Fibronectin Drives Fibroblast Accumulation at the Surface of Collagen Microtissues during Cell-Induced Tissue Morphogenesis. Plos One. 11: e0160369. PMID 27564551 DOI: 10.1371/Journal.Pone.0160369  0.427
2016 Kutys ML, Chen CS. Forces and mechanotransduction in 3D vascular biology. Current Opinion in Cell Biology. 42: 73-79. PMID 27209346 DOI: 10.1016/J.Ceb.2016.04.011  0.395
2016 Polacheck WJ, Chen CS. Measuring cell-generated forces: a guide to the available tools. Nature Methods. 13: 415-423. PMID 27123817 DOI: 10.1038/Nmeth.3834  0.363
2016 Sakar MS, Eyckmans J, Pieters R, Eberli D, Nelson BJ, Chen CS. Cellular forces and matrix assembly coordinate fibrous tissue repair. Nature Communications. 7: 11036. PMID 26980715 DOI: 10.1038/Ncomms11036  0.415
2016 Mui KL, Chen CS, Assoian RK. The mechanical regulation of integrin-cadherin crosstalk organizes cells, signaling and forces. Journal of Cell Science. PMID 26919980 DOI: 10.1242/Jcs.183699  0.396
2016 Heo S, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA, Mauck RL. Author response: Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity Elife. DOI: 10.7554/Elife.18207.028  0.317
2016 Lee E, Song HHG, Chen CS. Biomimetic on-a-chip platforms for studying cancer metastasis Current Opinion in Chemical Engineering. 11: 20-27. DOI: 10.1016/j.coche.2015.12.001  0.756
2015 Baker BM, Trappmann B, Wang WY, Sakar MS, Kim IL, Shenoy VB, Burdick JA, Chen CS. Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments. Nature Materials. PMID 26461445 DOI: 10.1038/Nmat4444  0.428
2015 Wu HC, Chen TC, Lai NC, Yang CM, Wu JH, Chen YC, Lee JF, Chen CS. Synthesis of sub-nanosized Pt particles on mesoporous SBA-15 material and its application to the CO oxidation reaction. Nanoscale. PMID 26403094 DOI: 10.1039/c5nr04943a  0.327
2015 Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, Gorham J, Yang L, Schafer S, Sheng CC, Haghighi A, Homsy J, Hubner N, Church G, Cook SA, ... ... Chen CS, et al. HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Science (New York, N.Y.). 349: 982-6. PMID 26315439 DOI: 10.1126/Science.Aaa5458  0.741
2015 Henry SJ, Chen CS, Crocker JC, Hammer DA. Protrusive and Contractile Forces of Spreading Human Neutrophils. Biophysical Journal. 109: 699-709. PMID 26287622 DOI: 10.1016/J.Bpj.2015.05.041  0.343
2015 Cohen DM, Won KJ, Nguyen N, Lazar MA, Chen C, Steger D. ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis. Elife. 4. PMID 26111340 DOI: 10.7554/Elife.06821  0.317
2015 Stevens KR, Miller JS, Blakely BL, Chen CS, Bhatia SN. Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering. Journal of Biomedical Materials Research. Part A. PMID 25851120 DOI: 10.1002/Jbm.A.35478  0.791
2015 Poon E, Keung W, Liang Y, Ramalingam R, Yan B, Zhang S, Chopra A, Moore J, Herren A, Lieu DK, Wong HS, Weng Z, Wong OT, Lam YW, Tomaselli GF, ... Chen C, et al. Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation. Circulation. Cardiovascular Genetics. 8: 427-36. PMID 25759434 DOI: 10.1161/Circgenetics.114.000918  0.732
2015 Mui KL, Bae YH, Gao L, Liu SL, Xu T, Radice GL, Chen CS, Assoian RK. N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells. Cell Reports. PMID 25753414 DOI: 10.1016/J.Celrep.2015.02.023  0.407
2015 Elliott H, Fischer RS, Myers KA, Desai RA, Gao L, Chen CS, Adelstein RS, Waterman CM, Danuser G. Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature. Nature Cell Biology. 17: 137-47. PMID 25621949 DOI: 10.1038/Ncb3092  0.652
2015 Rana MK, Srivastava J, Yang M, Chen CS, Barber DL. Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation. Journal of Cell Science. 128: 1083-9. PMID 25616899 DOI: 10.1242/Jcs.155036  0.581
2015 Byron A, Askari JA, Humphries JD, Jacquemet G, Koper EJ, Warwood S, Choi CK, Stroud MJ, Chen CS, Knight D, Humphries MJ. A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting. Nature Communications. 6: 6135. PMID 25609142 DOI: 10.1038/Ncomms7135  0.34
2015 Galie PA, van Oosten A, Chen CS, Janmey PA. Application of multiple levels of fluid shear stress to endothelial cells plated on polyacrylamide gels. Lab On a Chip. 15: 1205-12. PMID 25573790 DOI: 10.1039/C4Lc01236D  0.559
2015 Ronan W, McMeeking RM, Chen CS, McGarry JP, Deshpande VS. Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions. Journal of Biomechanics. 48: 520-8. PMID 25553672 DOI: 10.1016/J.Jbiomech.2014.11.025  0.42
2015 Chen G, Li S, Karakikes I, Ren L, Chow MZ, Chopra A, Keung W, Yan B, Chan CW, Costa KD, Kong CW, Hajjar RJ, Chen CS, Li RA. Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs. Circulation. Arrhythmia and Electrophysiology. 8: 193-202. PMID 25504561 DOI: 10.1161/Circep.114.002049  0.747
2015 Chaturvedi RR, Stevens KR, Solorzano RD, Schwartz RE, Eyckmans J, Baranski JD, Stapleton SC, Bhatia SN, Chen CS. Patterning vascular networks in vivo for tissue engineering applications. Tissue Engineering. Part C, Methods. 21: 509-17. PMID 25390971 DOI: 10.1089/Ten.Tec.2014.0258  0.804
2015 Galie PA, Byfield FJ, Chen CS, Kresh JY, Janmey PA. Mechanically stimulated contraction of engineered cardiac constructs using a microcantilever. Ieee Transactions On Bio-Medical Engineering. 62: 438-42. PMID 25248171 DOI: 10.1109/Tbme.2014.2357778  0.721
2015 Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW. Correction: Design and formulation of functional pluripotent stem cell-derived cardiac microtissues (Proceedings of the National Academy of Sciences (2013) 110, (E4698-E4707) DOI:10.1073/pnas.1311120110) Proceedings of the National Academy of Sciences of the United States of America. 112: E3151. DOI: 10.1073/Pnas.1311120110).  0.515
2015 Henry SJ, Chen CS, Crocker JC, Hammer DA. Dynamic Traction Forces of Human Neutrophil Adhesion Biophysical Journal. 108: 495a. DOI: 10.1016/J.Bpj.2014.11.2706  0.387
2014 Breckenridge MT, Desai RA, Yang MT, Fu J, Chen CS. Substrates with engineered step changes in rigidity induce traction force polarity and durotaxis. Cellular and Molecular Bioengineering. 7: 26-34. PMID 27721906 DOI: 10.1007/S12195-013-0307-6  0.74
2014 Wang H, Abhilash AS, Chen CS, Wells RG, Shenoy VB. Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers. Biophysical Journal. 107: 2592-603. PMID 25468338 DOI: 10.1016/J.Bpj.2014.09.044  0.329
2014 Abhilash AS, Baker BM, Trappmann B, Chen CS, Shenoy VB. Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations. Biophysical Journal. 107: 1829-40. PMID 25418164 DOI: 10.1016/J.Bpj.2014.08.029  0.383
2014 Blakely BL, Dumelin CE, Trappmann B, McGregor LM, Choi CK, Anthony PC, Duesterberg VK, Baker BM, Block SM, Liu DR, Chen CS. A DNA-based molecular probe for optically reporting cellular traction forces. Nature Methods. 11: 1229-32. PMID 25306545 DOI: 10.1038/Nmeth.3145  0.789
2014 Bellas E, Chen CS. Forms, forces, and stem cell fate. Current Opinion in Cell Biology. 31: 92-7. PMID 25269668 DOI: 10.1016/J.Ceb.2014.09.006  0.465
2014 Atluri P, Miller JS, Emery RJ, Hung G, Trubelja A, Cohen JE, Lloyd K, Han J, Gaffey AC, MacArthur JW, Chen CS, Woo YJ. Tissue-engineered, hydrogel-based endothelial progenitor cell therapy robustly revascularizes ischemic myocardium and preserves ventricular function. The Journal of Thoracic and Cardiovascular Surgery. 148: 1090-7; discussion 1. PMID 25129603 DOI: 10.1016/J.Jtcvs.2014.06.038  0.44
2014 Moreno V, Gonzalo P, Gómez-Escudero J, Pollán Á, Acín-Pérez R, Breckenridge M, Yáñez-Mó M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enríquez JA, Dejana E, Sánchez-Madrid F, Arroyo AG. An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. Journal of Cell Science. 127: 3768-81. PMID 24994937 DOI: 10.1242/Jcs.149518  0.391
2014 Eyckmans J, Chen CS. Stem cell differentiation: sticky mechanical memory. Nature Materials. 13: 542-3. PMID 24845990 DOI: 10.1038/Nmat3989  0.345
2014 Galie PA, Nguyen DH, Choi CK, Cohen DM, Janmey PA, Chen CS. Fluid shear stress threshold regulates angiogenic sprouting. Proceedings of the National Academy of Sciences of the United States of America. 111: 7968-73. PMID 24843171 DOI: 10.1073/Pnas.1310842111  0.773
2014 Zhao R, Boudou T, Wang WG, Chen CS, Reich DH. Magnetic approaches to study collective three-dimensional cell mechanics in long-term cultures (invited). Journal of Applied Physics. 115: 172616. PMID 24803684 DOI: 10.1063/1.4870918  0.735
2014 Stapleton SC, Chopra A, Chen CS. Force measurement tools to explore cadherin mechanotransduction. Cell Communication & Adhesion. 21: 193-205. PMID 24754475 DOI: 10.3109/15419061.2014.905929  0.825
2014 Choi CK, Chen CS. Jostling for position in angiogenic sprouts: continuous rearrangement of cells explained by differential adhesion dynamics. The Embo Journal. 33: 1089-90. PMID 24711516 DOI: 10.1002/Embj.201488452  0.442
2014 Zhao R, Chen CS, Reich DH. Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening. Biomaterials. 35: 5056-64. PMID 24630092 DOI: 10.1016/J.Biomaterials.2014.02.020  0.733
2014 Ramade A, Legant WR, Picart C, Chen CS, Boudou T. Microfabrication of a platform to measure and manipulate the mechanics of engineered microtissues. Methods in Cell Biology. 121: 191-211. PMID 24560511 DOI: 10.1016/B978-0-12-800281-0.00013-0  0.701
2014 van Spreeuwel AC, Bax NA, Bastiaens AJ, Foolen J, Loerakker S, Borochin M, van der Schaft DW, Chen CS, Baaijens FP, Bouten CV. The influence of matrix (an)isotropy on cardiomyocyte contraction in engineered cardiac microtissues. Integrative Biology : Quantitative Biosciences From Nano to Macro. 6: 422-9. PMID 24549279 DOI: 10.1039/C3Ib40219C  0.367
2014 Desai RA, Rodriguez NM, Chen CS. "Stamp-off" to micropattern sparse, multicomponent features. Methods in Cell Biology. 119: 3-16. PMID 24439276 DOI: 10.1016/B978-0-12-416742-1.00001-9  0.751
2014 Thompson SA, Blazeski A, Copeland CR, Cohen DM, Chen CS, Reich DM, Tung L. Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin. Journal of Molecular and Cellular Cardiology. 68: 29-37. PMID 24412534 DOI: 10.1016/J.Yjmcc.2013.12.025  0.356
2014 Rodriguez NM, Desai RA, Trappmann B, Baker BM, Chen CS. Micropatterned multicolor dynamically adhesive substrates to control cell adhesion and multicellular organization. Langmuir : the Acs Journal of Surfaces and Colloids. 30: 1327-35. PMID 24401172 DOI: 10.1021/La404037S  0.762
2014 Li F, Xu T, Nguyen DH, Huang X, Chen CS, Zhou C. Label-free evaluation of angiogenic sprouting in microengineered devices using ultrahigh-resolution optical coherence microscopy. Journal of Biomedical Optics. 19: 16006. PMID 24395588 DOI: 10.1117/1.Jbo.19.1.016006  0.726
2014 Chopra A, Murray ME, Byfield FJ, Mendez MG, Halleluyan R, Restle DJ, Raz-Ben Aroush D, Galie PA, Pogoda K, Bucki R, Marcinkiewicz C, Prestwich GD, Zarembinski TI, Chen CS, Puré E, et al. Augmentation of integrin-mediated mechanotransduction by hyaluronic acid. Biomaterials. 35: 71-82. PMID 24120037 DOI: 10.1016/J.Biomaterials.2013.09.066  0.825
2014 Stevens K, Ungrin M, Schwartz R, Ng S, Carvalho B, Christine K, Chaturvedi R, Li C, Zandstra P, Chen C, Bhatia S. Erratum: InVERT molding for scalable control of tissue microarchitecture Nature Communications. 5. DOI: 10.1038/Ncomms4148  0.76
2014 Shenoy VB, Wang H, Svoronos AA, Boudou T, Morgan JR, Chen CS. Necking and Failure of Constrained Contractile 3D Microtissues Induced by Cell Derived Tension Biophysical Journal. 106: 614a-615a. DOI: 10.1016/J.Bpj.2013.11.3401  0.36
2014 Breckenridge MT, Desai RA, Yang MT, Fu J, Chen CS. Substrates with engineered step changes in rigidity induce traction force polarity and durotaxis Cellular and Molecular Bioengineering. 7: 26-34. DOI: 10.1007/s12195-013-0307-6  0.65
2013 Vunjak-Novakovic G, Bhatia S, Chen C, Hirschi K. HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease. Stem Cell Research & Therapy. 4: S8. PMID 24565063 DOI: 10.1186/Scrt369  0.335
2013 Wang H, Svoronos AA, Boudou T, Sakar MS, Schell JY, Morgan JR, Chen CS, Shenoy VB. Necking and failure of constrained 3D microtissues induced by cellular tension. Proceedings of the National Academy of Sciences of the United States of America. 110: 20923-8. PMID 24324149 DOI: 10.1073/Pnas.1313662110  0.348
2013 Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW. Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proceedings of the National Academy of Sciences of the United States of America. 110: E4698-707. PMID 24255110 DOI: 10.1073/Pnas.1311120110  0.58
2013 He J, Kelly TN, Zhao Q, Li H, Huang J, Wang L, Jaquish CE, Sung YJ, Shimmin LC, Lu F, Mu J, Hu D, Ji X, Shen C, Guo D, ... ... Chen CS, et al. Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese. Circulation. Cardiovascular Genetics. 6: 598-607. PMID 24165912 DOI: 10.1161/Circgenetics.113.000307  0.355
2013 Desai RA, Gopal SB, Chen S, Chen CS. Contact inhibition of locomotion probabilities drive solitary versus collective cell migration. Journal of the Royal Society, Interface / the Royal Society. 10: 20130717. PMID 24047876 DOI: 10.1098/Rsif.2013.0717  0.651
2013 Wozniak MA, Baker BM, Chen CS, Wilson KL. The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions. Peerj. 1: e134. PMID 24010014 DOI: 10.7717/Peerj.134  0.336
2013 Cohen DM, Yang MT, Chen CS. Measuring cell-cell tugging forces using bowtie-patterned mPADs (microarray post detectors). Methods in Molecular Biology (Clifton, N.J.). 1066: 157-68. PMID 23955742 DOI: 10.1007/978-1-62703-604-7_14  0.63
2013 Jacquemet G, Morgan MR, Byron A, Humphries JD, Choi CK, Chen CS, Caswell PT, Humphries MJ. Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. Journal of Cell Science. 126: 4121-35. PMID 23843620 DOI: 10.1242/Jcs.121988  0.364
2013 Wang C, Baker BM, Chen CS, Schwartz MA. Endothelial cell sensing of flow direction. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2130-6. PMID 23814115 DOI: 10.1161/Atvbaha.113.301826  0.319
2013 Baker BM, Trappmann B, Stapleton SC, Toro E, Chen CS. Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients. Lab On a Chip. 13: 3246-52. PMID 23787488 DOI: 10.1039/C3Lc50493J  0.804
2013 Dumbauld DW, Lee TT, Singh A, Scrimgeour J, Gersbach CA, Zamir EA, Fu J, Chen CS, Curtis JE, Craig SW, García AJ. How vinculin regulates force transmission. Proceedings of the National Academy of Sciences of the United States of America. 110: 9788-93. PMID 23716647 DOI: 10.1073/Pnas.1216209110  0.666
2013 Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA. Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Current Biology : Cb. 23: 1024-30. PMID 23684974 DOI: 10.1016/J.Cub.2013.04.049  0.374
2013 Stevens KR, Ungrin MD, Schwartz RE, Ng S, Carvalho B, Christine KS, Chaturvedi RR, Li CY, Zandstra PW, Chen CS, Bhatia SN. InVERT molding for scalable control of tissue microarchitecture. Nature Communications. 4: 1847. PMID 23673632 DOI: 10.1038/Ncomms2853  0.401
2013 Wang YK, Chen CS. Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation. Journal of Cellular and Molecular Medicine. 17: 823-32. PMID 23672518 DOI: 10.1111/Jcmm.12061  0.388
2013 Kim IL, Khetan S, Baker BM, Chen CS, Burdick JA. Fibrous hyaluronic acid hydrogels that direct MSC chondrogenesis through mechanical and adhesive cues. Biomaterials. 34: 5571-80. PMID 23623322 DOI: 10.1016/J.Biomaterials.2013.04.004  0.347
2013 Trappmann B, Chen CS. How cells sense extracellular matrix stiffness: a material's perspective. Current Opinion in Biotechnology. 24: 948-53. PMID 23611564 DOI: 10.1016/J.Copbio.2013.03.020  0.39
2013 Baranski JD, Chaturvedi RR, Stevens KR, Eyckmans J, Carvalho B, Solorzano RD, Yang MT, Miller JS, Bhatia SN, Chen CS. Geometric control of vascular networks to enhance engineered tissue integration and function. Proceedings of the National Academy of Sciences of the United States of America. 110: 7586-91. PMID 23610423 DOI: 10.1073/Pnas.1217796110  0.799
2013 Nguyen DH, Stapleton SC, Yang MT, Cha SS, Choi CK, Galie PA, Chen CS. Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. Proceedings of the National Academy of Sciences of the United States of America. 110: 6712-7. PMID 23569284 DOI: 10.1073/Pnas.1221526110  0.803
2013 Eyckmans J, Roberts SJ, Bolander J, Schrooten J, Chen CS, Luyten FP. Mapping calcium phosphate activated gene networks as a strategy for targeted osteoinduction of human progenitors. Biomaterials. 34: 4612-21. PMID 23537666 DOI: 10.1016/J.Biomaterials.2013.03.011  0.306
2013 Khetan S, Guvendiren M, Legant WR, Cohen DM, Chen CS, Burdick JA. Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nature Materials. 12: 458-65. PMID 23524375 DOI: 10.1038/Nmat3586  0.735
2013 Lin GL, Cohen DM, Desai RA, Breckenridge MT, Gao L, Humphries MJ, Chen CS. Activation of beta 1 but not beta 3 integrin increases cell traction forces. Febs Letters. 587: 763-9. PMID 23395612 DOI: 10.1016/J.Febslet.2013.01.068  0.72
2013 Zhao R, Boudou T, Wang WG, Chen CS, Reich DH. Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers. Advanced Materials (Deerfield Beach, Fla.). 25: 1699-705. PMID 23355085 DOI: 10.1002/Adma.201203585  0.717
2013 Schwartz MA, Chen CS. Cell biology. Deconstructing dimensionality. Science (New York, N.Y.). 339: 402-4. PMID 23349278 DOI: 10.1126/Science.1233814  0.384
2013 Legant WR, Choi CK, Miller JS, Shao L, Gao L, Betzig E, Chen CS. Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions. Proceedings of the National Academy of Sciences of the United States of America. 110: 881-6. PMID 23277584 DOI: 10.1073/Pnas.1207997110  0.73
2013 Mori H, Lo AT, Inman JL, Alcaraz J, Ghajar CM, Mott JD, Nelson CM, Chen CS, Zhang H, Bascom JL, Seiki M, Bissell MJ. Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1. Development (Cambridge, England). 140: 343-52. PMID 23250208 DOI: 10.1242/Jcs.130054  0.601
2013 West AR, Zaman N, Cole DJ, Walker MJ, Legant WR, Boudou T, Chen CS, Favreau JT, Gaudette GR, Cowley EA, Maksym GN. Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L4-16. PMID 23125251 DOI: 10.1152/Ajplung.00168.2012  0.724
2013 Xu T, Li F, Nguyen DHT, Chen CS, Zhou C, Huang X. Delineating 3D angiogenic sprouting in OCT images via multiple active contours Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 8090: 231-240. DOI: 10.1007/978-3-642-40843-4_25  0.696
2012 Leight JL, Liu WF, Chaturvedi RR, Chen S, Yang MT, Raghavan S, Chen CS. Manipulation of 3D Cluster Size and Geometry by Release from 2D Micropatterns. Cellular and Molecular Bioengineering. 5: 299-306. PMID 23730348 DOI: 10.1007/S12195-012-0236-9  0.788
2012 Eyckmans J, Lin GL, Chen CS. Adhesive and mechanical regulation of mesenchymal stem cell differentiation in human bone marrow and periosteum-derived progenitor cells. Biology Open. 1: 1058-68. PMID 23213385 DOI: 10.1242/Bio.20122162  0.589
2012 Tian WH, Liu TC, Chen CS, Liu LF, Tien JJ. The relationship between depressive symptoms and health service utilization for elderly people in Taiwan. Health Policy (Amsterdam, Netherlands). 108: 256-67. PMID 23102721 DOI: 10.1016/j.healthpol.2012.10.005  0.702
2012 Wozniak MA, Cheng CQ, Shen CJ, Gao L, Olarerin-George AO, Won KJ, Hogenesch JB, Chen CS. Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch. Current Biology : Cb. 22: 2017-26. PMID 23063436 DOI: 10.1016/J.Cub.2012.08.050  0.687
2012 Underhill GH, Galie P, Chen CS, Bhatia SN. Bioengineering methods for analysis of cells in vitro. Annual Review of Cell and Developmental Biology. 28: 385-410. PMID 23057744 DOI: 10.1146/Annurev-Cellbio-101011-155709  0.391
2012 Legant WR, Chen CS, Vogel V. Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1164-74. PMID 22961409 DOI: 10.1039/C2Ib20059G  0.732
2012 Baker BM, Chen CS. Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. Journal of Cell Science. 125: 3015-24. PMID 22797912 DOI: 10.1242/Jcs.079509  0.385
2012 Miller JS, Stevens KR, Yang MT, Baker BM, Nguyen DH, Cohen DM, Toro E, Chen AA, Galie PA, Yu X, Chaturvedi R, Bhatia SN, Chen CS. Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nature Materials. 11: 768-74. PMID 22751181 DOI: 10.1038/Nmat3357  0.805
2012 Felton EJ, Copeland CR, Chen CS, Reich DH. Heterotypic cell pair co-culturing on patterned microarrays. Lab On a Chip. 12: 3117-26. PMID 22739471 DOI: 10.1039/C2Lc40349H  0.638
2012 Sun Y, Chen CS, Fu J. Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment. Annual Review of Biophysics. 41: 519-42. PMID 22404680 DOI: 10.1146/Annurev-Biophys-042910-155306  0.414
2012 Lin YC, Kramer CM, Chen CS, Reich DH. Probing cellular traction forces with magnetic nanowires and microfabricated force sensor arrays. Nanotechnology. 23: 075101. PMID 22260885 DOI: 10.1088/0957-4484/23/7/075101  0.604
2012 Leight JL, Wozniak MA, Chen S, Lynch ML, Chen CS. Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition. Molecular Biology of the Cell. 23: 781-91. PMID 22238361 DOI: 10.1091/Mbc.E11-06-0537  0.743
2012 Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS. A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Engineering. Part A. 18: 910-9. PMID 22092279 DOI: 10.1089/Ten.Tea.2011.0341  0.724
2012 Wang YK, Yu X, Cohen DM, Wozniak MA, Yang MT, Gao L, Eyckmans J, Chen CS. Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension. Stem Cells and Development. 21: 1176-86. PMID 21967638 DOI: 10.1089/Scd.2011.0293  0.602
2012 Zhao R, Boudou T, Chen CS, Reich DH. Magnetic microtissue stretching system to study the mechanobiology of 3d fibroblast populated collagen matrix Asme 2012 Summer Bioengineering Conference, Sbc 2012. 691-692. DOI: 10.1115/SBC2012-80689  0.649
2012 Khetan S, Legant WR, Chen CS, Burdick JA. Stem cell fate within 3D hydrogels is mediated by network structure-dependent traction generation Asme 2012 Summer Bioengineering Conference, Sbc 2012. 527-528. DOI: 10.1115/SBC2012-80277  0.661
2012 Pathak A, Chen CS, Evans AG, McMeeking RM. Structural mechanics based model for the force-bearing elements within the cytoskeleton of a cell adhered on a bed of posts Journal of Applied Mechanics, Transactions Asme. 79. DOI: 10.1115/1.4006452  0.357
2012 Chen CS. Engineered Microenvironments: A Materials Approach to the Regulation of Cell Function Biophysical Journal. 102: 4-7. DOI: 10.1016/J.Bpj.2011.11.2338  0.465
2011 Ricart BG, Yang MT, Hunter CA, Chen CS, Hammer DA. Measuring traction forces of motile dendritic cells on micropost arrays. Biophysical Journal. 101: 2620-8. PMID 22261049 DOI: 10.1016/J.Bpj.2011.09.022  0.566
2011 Cristancho AG, Schupp M, Lefterova MI, Cao S, Cohen DM, Chen CS, Steger DJ, Lazar MA. Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 16271-6. PMID 21914845 DOI: 10.1073/Pnas.1109409108  0.351
2011 Eyckmans J, Boudou T, Yu X, Chen CS. A hitchhiker's guide to mechanobiology. Developmental Cell. 21: 35-47. PMID 21763607 DOI: 10.1016/J.Devcel.2011.06.015  0.355
2011 Liaw CC, Liao WY, Chen CS, Jao SC, Wu YC, Shen CN, Wu SH. The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins. Angewandte Chemie (International Ed. in English). 50: 7885-91. PMID 21744442 DOI: 10.1002/anie.201100717  0.342
2011 Shen CJ, Raghavan S, Xu Z, Baranski JD, Yu X, Wozniak MA, Miller JS, Gupta M, Buckbinder L, Chen CS. Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner. Experimental Cell Research. 317: 1860-71. PMID 21640103 DOI: 10.1016/J.Yexcr.2011.05.006  0.818
2011 Yang MT, Reich DH, Chen CS. Measurement and analysis of traction force dynamics in response to vasoactive agonists. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 663-74. PMID 21445393 DOI: 10.1039/C0Ib00156B  0.746
2011 Gao L, Gorski JL, Chen CS. The Cdc42 guanine nucleotide exchange factor FGD1 regulates osteogenesis in human mesenchymal stem cells. The American Journal of Pathology. 178: 969-74. PMID 21356349 DOI: 10.1016/J.Ajpath.2010.11.051  0.339
2011 Tee SY, Fu J, Chen CS, Janmey PA. Cell shape and substrate rigidity both regulate cell stiffness Biophysical Journal. 100: L25-L27. PMID 21354386 DOI: 10.1016/J.Bpj.2010.12.3744  0.585
2011 Desai RA, Khan MK, Gopal SB, Chen CS. Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfaces. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 560-7. PMID 21298148 DOI: 10.1039/C0Ib00129E  0.647
2011 Yang MT, Fu J, Wang YK, Desai RA, Chen CS. Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity. Nature Protocols. 6: 187-213. PMID 21293460 DOI: 10.1038/Nprot.2010.189  0.731
2011 Joy A, Cohen DM, Luk A, Anim-Danso E, Chen C, Kohn J. Control of surface chemistry, substrate stiffness, and cell function in a novel terpolymer methacrylate library Langmuir. 27: 1891-1899. PMID 21226505 DOI: 10.1021/La103722M  0.371
2011 Leslie-Barbick JE, Shen C, Chen C, West JL. Micron-scale spatially patterned, covalently immobilized vascular endothelial growth factor on hydrogels accelerates endothelial tubulogenesis and increases cellular angiogenic responses. Tissue Engineering. Part A. 17: 221-9. PMID 20712418 DOI: 10.1089/Ten.Tea.2010.0202  0.547
2011 Fu J, Wang Y, Yang MT, Desai RA, Yu X, Liu Z, Chen CS. Addendum: Mechanical regulation of cell function with geometrically modulated elastomeric substrates Nature Methods. 8: 184-184. DOI: 10.1038/Nmeth0211-184A  0.751
2011 Lemmon CA, Chen CS, Romer L. Mechanics and Biochemistry of Matrix Assembly: Pulling it all Together Biophysical Journal. 100: 447a. DOI: 10.1016/J.Bpj.2010.12.2635  0.697
2011 Legant WR, Miller JS, Blakely BL, Cohen D, Genin GM, Chen CS. A general Approach to Measure Three-Dimensional Forces from Cells Biophysical Journal. 100: 190a. DOI: 10.1016/J.Bpj.2010.12.1258  0.816
2010 Legant WR, Miller JS, Blakely BL, Cohen DM, Genin GM, Chen CS. Measurement of mechanical tractions exerted by cells in three-dimensional matrices. Nature Methods. 7: 969-71. PMID 21076420 DOI: 10.1038/Nmeth.1531  0.817
2010 Choi CK, Breckenridge MT, Chen CS. Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering. Trends in Cell Biology. 20: 705-14. PMID 20965727 DOI: 10.1016/J.Tcb.2010.09.007  0.426
2010 Sriraghavan V, Desai RA, Kwon Y, Mrksich M, Chen CS. Micropatterned dynamically adhesive substrates for cell migration Langmuir. 26: 17733-17738. PMID 20886900 DOI: 10.1021/La102955M  0.74
2010 Liu Z, Sniadecki NJ, Chen CS. Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes. Cellular and Molecular Bioengineering. 3: 50-59. PMID 20862208 DOI: 10.1007/S12195-010-0105-3  0.567
2010 Raghavan S, Shen CJ, Desai RA, Sniadecki NJ, Nelson CM, Chen CS. Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis. Journal of Cell Science. 123: 2877-83. PMID 20682635 DOI: 10.1242/Jcs.055079  0.783
2010 Fu J, Wang YK, Yang MT, Desai RA, Yu X, Liu Z, Chen CS. Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nature Methods. 7: 733-6. PMID 20676108 DOI: 10.1038/Nmeth.1487  0.772
2010 Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, Schwartz MA. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature. 466: 263-6. PMID 20613844 DOI: 10.1038/Nature09198  0.569
2010 Liu Z, Tan JL, Cohen DM, Yang MT, Sniadecki NJ, Ruiz SA, Nelson CM, Chen CS. Mechanical tugging force regulates the size of cell-cell junctions. Proceedings of the National Academy of Sciences of the United States of America. 107: 9944-9. PMID 20463286 DOI: 10.1073/Pnas.0914547107  0.807
2010 Raghavan S, Nelson CM, Baranski JD, Lim E, Chen CS. Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue Engineering. Part A. 16: 2255-63. PMID 20180698 DOI: 10.1089/Ten.Tea.2009.0584  0.821
2010 Miller JS, Shen CJ, Legant WR, Baranski JD, Blakely BL, Chen CS. Bioactive hydrogels made from step-growth derived PEG-peptide macromers. Biomaterials. 31: 3736-43. PMID 20138664 DOI: 10.1016/J.Biomaterials.2010.01.058  0.796
2010 Gao L, McBeath R, Chen CS. Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin. Stem Cells (Dayton, Ohio). 28: 564-72. PMID 20082286 DOI: 10.1002/Stem.308  0.757
2010 Treiser MD, Yang EH, Gordonov S, Cohen DM, Androulakis IP, Kohn J, Chen CS, Moghe PV. Cytoskeleton-based forecasting of stem cell lineage fates. Proceedings of the National Academy of Sciences of the United States of America. 107: 610-5. PMID 20080726 DOI: 10.1073/Pnas.0909597107  0.383
2009 McGarry JP, Fu J, Yang MT, Chen CS, McMeeking RM, Evans AG, Deshpande VS. Simulation of the contractile response of cells on an array of micro-posts. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 367: 3477-97. PMID 19657008 DOI: 10.1098/Rsta.2009.0097  0.607
2009 Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell. 5: 17-26. PMID 19570510 DOI: 10.1016/J.Stem.2009.06.016  0.399
2009 Legant WR, Pathak A, Yang MT, Deshpande VS, McMeeking RM, Chen CS. Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues. Proceedings of the National Academy of Sciences of the United States of America. 106: 10097-102. PMID 19541627 DOI: 10.1073/Pnas.0900174106  0.776
2009 Desai RA, Gao L, Raghavan S, Liu WF, Chen CS. Cell polarity triggered by cell-cell adhesion via E-cadherin. Journal of Cell Science. 122: 905-11. PMID 19258396 DOI: 10.1242/Jcs.028183  0.738
2009 Ostuni E, Whitesides GM, Ingber DE, Chen CS. Using self-assembled monolayers to pattern ECM proteins and cells on substrates. Methods in Molecular Biology (Clifton, N.J.). 522: 183-94. PMID 19247618 DOI: 10.1007/978-1-59745-413-1_12  0.831
2009 Wozniak MA, Chen CS. Mechanotransduction in development: a growing role for contractility. Nature Reviews. Molecular Cell Biology. 10: 34-43. PMID 19197330 DOI: 10.1038/Nrm2592  0.418
2009 Lemmon CA, Chen CS, Romer LH. Cell traction forces direct fibronectin matrix assembly. Biophysical Journal. 96: 729-38. PMID 19167317 DOI: 10.1016/J.Bpj.2008.10.009  0.776
2009 Chen CS, Nelson CM, Khauv D, Bennett S, Radisky ES, Hirai Y, Bissell MJ, Radisky DC. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. The Journal of Biological Chemistry. 284: 6877-84. PMID 19129200 DOI: 10.1074/Jbc.M805908200  0.573
2008 Cohen DM, Chen CS. Mechanical control of stem cell differentiation Stembook. PMID 20614621 DOI: 10.3824/Stembook.1.26.1  0.385
2008 Chen CS. Mechanotransduction - a field pulling together? Journal of Cell Science. 121: 3285-92. PMID 18843115 DOI: 10.1242/Jcs.023507  0.379
2008 Wang AY, Leong S, Liang YC, Huang RC, Chen CS, Yu SM. Immobilization of growth factors on collagen scaffolds mediated by polyanionic collagen mimetic peptides and its effect on endothelial cell morphogenesis. Biomacromolecules. 9: 2929-36. PMID 18816098 DOI: 10.1021/Bm800727Z  0.363
2008 Ruiz SA, Chen CS. Emergence of patterned stem cell differentiation within multicellular structures. Stem Cells (Dayton, Ohio). 26: 2921-7. PMID 18703661 DOI: 10.1634/Stemcells.2008-0432  0.368
2008 Chen CS. Biotechnology: remote control of living cells. Nature Nanotechnology. 3: 13-4. PMID 18654443 DOI: 10.1038/Nnano.2007.431  0.329
2008 Gray DS, Liu WF, Shen CJ, Bhadriraju K, Nelson CM, Chen CS. Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Experimental Cell Research. 314: 2846-54. PMID 18652824 DOI: 10.1016/J.Yexcr.2008.06.023  0.773
2008 Parker KK, Tan J, Chen CS, Tung L. Myofibrillar architecture in engineered cardiac myocytes. Circulation Research. 103: 340-2. PMID 18635822 DOI: 10.1161/Circresaha.108.182469  0.698
2008 Sniadecki NJ, Lamb CM, Liu Y, Chen CS, Reich DH. Magnetic microposts for mechanical stimulation of biological cells: fabrication, characterization, and analysis. The Review of Scientific Instruments. 79: 044302. PMID 18447536 DOI: 10.1063/1.2906228  0.615
2008 Chen CS, Hiura Y, Shen CS, Iwai N. Assessment of mitochondrial DNA polymorphisms in salt-sensitive hypertension in Dahl salt-sensitive rats. Hypertension Research : Official Journal of the Japanese Society of Hypertension. 31: 107-15. PMID 18360025 DOI: 10.1291/hypres.31.107  0.341
2008 Pirone DM, Qi L, Colecraft H, Chen CS. Spatial patterning of gene expression using surface-immobilized recombinant adenovirus. Biomedical Microdevices. 10: 561-6. PMID 18246428 DOI: 10.1007/S10544-008-9166-7  0.337
2008 Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. Journal of Cell Science. 121: 226-33. PMID 18187454 DOI: 10.1242/Jcs.017012  0.373
2008 Chen CS, Ingber DE. Tensegrity and mechanoregulation: From skeleton to cytoskeleton | Tensegrity und mechanoregulation: Vom skelett zum zytoskelett Osteopathische Medizin. 9: 4-17. DOI: 10.1016/J.Ostmed.2008.09.010  0.543
2008 Shen CJ, Fu J, Chen CS. Patterning Cell and Tissue Function Cellular and Molecular Bioengineering. 1: 15-23. DOI: 10.1007/S12195-008-0005-Y  0.575
2007 Alom Ruiz S, Chen CS. Microcontact printing: A tool to pattern. Soft Matter. 3: 168-177. PMID 32680260 DOI: 10.1039/B613349E  0.767
2007 Desai R, Yang M, Sniadecki N, Legant W, Chen C. Microfabricated post-array-detectors (mPADs): an approach to isolate mechanical forces. Journal of Visualized Experiments : Jove. 311. PMID 18989444 DOI: 10.3791/311  0.806
2007 Desai R, Yang M, Sniadecki N, Legant W, Chen C. Microfabricated post-array-detectors (mPADs): an approach to isolate mechanical forces. Journal of Visualized Experiments : Jove. 311. PMID 18989444 DOI: 10.3791/311  0.806
2007 Gómez-Sjöberg R, Leyrat AA, Pirone DM, Chen CS, Quake SR. Versatile, fully automated, microfluidic cell culture system. Analytical Chemistry. 79: 8557-63. PMID 17953452 DOI: 10.1021/Ac071311W  0.357
2007 Liu WF, Chen CS. Cellular and multicellular form and function. Advanced Drug Delivery Reviews. 59: 1319-28. PMID 17884241 DOI: 10.1016/J.Addr.2007.08.011  0.449
2007 Sniadecki NJ, Anguelouch A, Yang MT, Lamb CM, Liu Z, Kirschner SB, Liu Y, Reich DH, Chen CS. Magnetic microposts as an approach to apply forces to living cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 14553-8. PMID 17804810 DOI: 10.1073/Pnas.0611613104  0.75
2007 Liu WF, Nelson CM, Tan JL, Chen CS. Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circulation Research. 101: e44-52. PMID 17712140 DOI: 10.1161/Circresaha.107.158329  0.715
2007 Bhadriraju K, Yang M, Alom Ruiz S, Pirone D, Tan J, Chen CS. Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Experimental Cell Research. 313: 3616-23. PMID 17673200 DOI: 10.1016/J.Yexcr.2007.07.002  0.801
2007 Sniadecki NJ, Chen CS. Microfabricated silicone elastomeric post arrays for measuring traction forces of adherent cells. Methods in Cell Biology. 83: 313-28. PMID 17613314 DOI: 10.1016/S0091-679X(07)83013-5  0.429
2007 Chen CS. Bait and switch: synthetic GEFs divert an input signal to diverse cellular responses. Developmental Cell. 13: 9-10. PMID 17609105 DOI: 10.1016/J.Devcel.2007.06.007  0.327
2007 Nelson CM, Liu WF, Chen CS. Manipulation of cell-cell adhesion using bowtie-shaped microwells. Methods in Molecular Biology (Clifton, N.J.). 370: 1-10. PMID 17416983 DOI: 10.1007/978-1-59745-353-0_1  0.607
2007 Chen CS. Separate but not equal: differential mechanical roles for Myosin isoforms. Biophysical Journal. 92: 2984-5. PMID 17325018 DOI: 10.1529/Biophysj.106.100065  0.379
2007 Alom Ruiz S, Chen CS. Microcontact printing: A tool to pattern Soft Matter. 3: 168-177. DOI: 10.1039/b613349e  0.759
2007 Yang MT, Sniadecki NJ, Chen CS. Geometric considerations of micro- To nanoscale elastomeric post arrays to study cellular traction forces Advanced Materials. 19: 3119-3123. DOI: 10.1002/Adma.200701956  0.615
2006 Pirone DM, Liu WF, Ruiz SA, Gao L, Raghavan S, Lemmon CA, Romer LH, Chen CS. An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. The Journal of Cell Biology. 174: 277-88. PMID 16847103 DOI: 10.1083/Jcb.200510062  0.798
2006 Vandenberghe LH, Wang L, Somanathan S, Zhi Y, Figueredo J, Calcedo R, Sanmiguel J, Desai RA, Chen CS, Johnston J, Grant RL, Gao G, Wilson JM. Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nature Medicine. 12: 967-71. PMID 16845388 DOI: 10.1038/Nm1445  0.589
2006 Liu WF, Nelson CM, Pirone DM, Chen CS. E-cadherin engagement stimulates proliferation via Rac1. The Journal of Cell Biology. 173: 431-41. PMID 16682529 DOI: 10.1083/Jcb.200510087  0.557
2006 Sniadecki NJ, Desai RA, Ruiz SA, Chen CS. Nanotechnology for cell-substrate interactions. Annals of Biomedical Engineering. 34: 59-74. PMID 16525764 DOI: 10.1007/S10439-005-9006-3  0.652
2006 Spector A, Jean R, Chen C. Finite-element model of the adhesion-cytoskeleton-nucleus mechanotrasnduction pathway in endothelial cells Journal of Biomechanics. 39: S398. DOI: 10.1016/S0021-9290(06)84613-0  0.337
2005 Lemmon CA, Sniadecki NJ, Ruiz SA, Tan JL, Romer LH, Chen CS. Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors. Mechanics & Chemistry of Biosystems : McB. 2: 1-16. PMID 16708468  0.803
2005 Jean RP, Chen CS, Spector AA. Finite-element analysis of the adhesion-cytoskeleton-nucleus mechanotransduction pathway during endothelial cell rounding: axisymmetric model. Journal of Biomechanical Engineering. 127: 594-600. PMID 16121529 DOI: 10.1115/1.1933997  0.387
2005 Nelson CM, Jean RP, Tan JL, Liu WF, Sniadecki NJ, Spector AA, Chen CS. Emergent patterns of growth controlled by multicellular form and mechanics. Proceedings of the National Academy of Sciences of the United States of America. 102: 11594-9. PMID 16049098 DOI: 10.1073/Pnas.0502575102  0.698
2005 Herndon TM, Pirone DM, Tsokos GC, Chen CS. T cell-to-T cell clustering enhances NF-kappaB activity by a PI3K signal mediated by Cbl-b and Rho. Biochemical and Biophysical Research Communications. 332: 1133-9. PMID 15922296 DOI: 10.1016/J.Bbrc.2005.05.064  0.308
2005 Tanase M, Felton EJ, Gray DS, Hultgren A, Chen CS, Reich DH. Assembly of multicellular constructs and microarrays of cells using magnetic nanowires. Lab On a Chip. 5: 598-605. PMID 15915251 DOI: 10.1039/B500243E  0.795
2005 Yim EK, Reano RM, Pang SW, Yee AF, Chen CS, Leong KW. Nanopattern-induced changes in morphology and motility of smooth muscle cells. Biomaterials. 26: 5405-13. PMID 15814139 DOI: 10.1016/J.Biomaterials.2005.01.058  0.398
2005 Hultgren A, Tanase M, Felton EJ, Bhadriraju K, Salem AK, Chen CS, Reich DH. Optimization of yield in magnetic cell separations using nickel nanowires of different lengths. Biotechnology Progress. 21: 509-15. PMID 15801791 DOI: 10.1021/Bp049734W  0.807
2005 Wang AY, Mo X, Chen CS, Yu SM. Facile modification of collagen directed by collagen mimetic peptides. Journal of the American Chemical Society. 127: 4130-1. PMID 15783169 DOI: 10.1021/Ja0431915  0.356
2005 Chen CS, Jiang X, Whitesides GM. Microengineering the Environment of Mammalian Cells in Culture Mrs Bulletin. 30: 194-201. DOI: 10.1557/Mrs2005.52  0.653
2005 Liu WF, Chen CS. Engineering biomaterials to control cell function Materials Today. 8: 28-35. DOI: 10.1016/S1369-7021(05)71222-0  0.351
2004 Pirone DM, Chen CS. Strategies for engineering the adhesive microenvironment. Journal of Mammary Gland Biology and Neoplasia. 9: 405-17. PMID 15838609 DOI: 10.1007/S10911-004-1410-Z  0.454
2004 Jean RP, Gray DS, Spector AA, Chen CS. Characterization of the nuclear deformation caused by changes in endothelial cell shape. Journal of Biomechanical Engineering. 126: 552-8. PMID 15648807 DOI: 10.1115/1.1800559  0.637
2004 Tan JL, Liu W, Nelson CM, Raghavan S, Chen CS. Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Engineering. 10: 865-72. PMID 15265304 DOI: 10.1089/1076327041348365  0.773
2004 Chen CS, Tan J, Tien J. Mechanotransduction at cell-matrix and cell-cell contacts. Annual Review of Biomedical Engineering. 6: 275-302. PMID 15255771 DOI: 10.1146/Annurev.Bioeng.6.040803.140040  0.833
2004 Gray DS, Tan JL, Voldman J, Chen CS. Dielectrophoretic registration of living cells to a microelectrode array. Biosensors & Bioelectronics. 19: 1765-74. PMID 15198083 DOI: 10.1016/J.Bios.2004.03.016  0.721
2004 Nelson CM, Pirone DM, Tan JL, Chen CS. Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Molecular Biology of the Cell. 15: 2943-53. PMID 15075376 DOI: 10.1091/Mbc.E03-10-0745  0.735
2004 McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Developmental Cell. 6: 483-95. PMID 15068789 DOI: 10.1016/S1534-5807(04)00075-9  0.794
2004 Gray DS, Tan JL, Voldman J, Chen CS. Dielectrophoretic registration of living cells to a microelectrode array. Biosensors & Bioelectronics. 19: 771-80. PMID 14709396 DOI: 10.1016/j.bios.2003.08.013  0.7
2004 Hultgren A, Tanase M, Chen CS, Reich DH. High-yield cell separations using magnetic nanowires Ieee Transactions On Magnetics. 40: 2988-2990. DOI: 10.1109/Tmag.2004.830406  0.801
2004 Raghavan S, Chen CS. Micropatterned environments in cell biology Advanced Materials. 16: 1303-1313. DOI: 10.1002/Adma.200400594  0.556
2004 Gray DS, Tien J, Chen CS. High‐Conductivity Elastomeric Electronics Advanced Materials. 16: 393-397. DOI: 10.1002/Adma.200306107  0.746
2003 Gray DS, Tien J, Chen CS. Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus. Journal of Biomedical Materials Research. Part A. 66: 605-14. PMID 12918044 DOI: 10.1002/Jbm.A.10585  0.824
2003 Nelson CM, Chen CS. VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. Journal of Cell Science. 116: 3571-81. PMID 12876221 DOI: 10.1242/Jcs.00680  0.611
2003 Chen CS, Alonso JL, Ostuni E, Whitesides GM, Ingber DE. Cell shape provides global control of focal adhesion assembly. Biochemical and Biophysical Research Communications. 307: 355-61. PMID 12859964 DOI: 10.1016/S0006-291X(03)01165-3  0.825
2003 Tan JL, Tien J, Pirone DM, Gray DS, Bhadriraju K, Chen CS. Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proceedings of the National Academy of Sciences of the United States of America. 100: 1484-9. PMID 12552122 DOI: 10.1073/Pnas.0235407100  0.825
2003 Reich DH, Tanase M, Hultgren A, Bauer LA, Chen CS, Meyer GJ. Biological applications of multifunctional magnetic nanowires (invited) Journal of Applied Physics. 93: 7275-7280. DOI: 10.1063/1.1558672  0.772
2003 Hultgren A, Tanase M, Chen CS, Meyer GJ, Reich DH. Cell manipulation using magnetic nanowires Journal of Applied Physics. 93: 7554-7556. DOI: 10.1063/1.1556204  0.786
2003 Birenbaum NS, Lai BT, Chen CS, Reich DH, Meyer GJ. Selective noncovalent adsorption of protein to bifunctional metallic nanowire surfaces Langmuir. 19: 9580-9582. DOI: 10.1021/La035657N  0.542
2003 Nelson CM, Raghavan S, Tan JL, Chen CS. Degradation of micropatterned surfaces by cell-dependent and -independent processes Langmuir. 19: 1493-1499. DOI: 10.1021/La026178B  0.761
2002 Bhadriraju K, Chen CS. Engineering cellular microenvironments to improve cell-based drug testing. Drug Discovery Today. 7: 612-20. PMID 12047872 DOI: 10.1016/S1359-6446(02)02273-0  0.435
2002 Nelson CM, Chen CS. Cell-cell signaling by direct contact increases cell proliferation via a PI3K-dependent signal. Febs Letters. 514: 238-42. PMID 11943158 DOI: 10.1016/S0014-5793(02)02370-0  0.607
2002 Tien J, Chen CS. Patterning the cellular microenvironment. Ieee Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society. 21: 95-8. PMID 11935995 DOI: 10.1109/MEMB.2002.993201  0.738
2002 Tien J, Nelson CM, Chen CS. Fabrication of aligned microstructures with a single elastomeric stamp. Proceedings of the National Academy of Sciences of the United States of America. 99: 1758-62. PMID 11842197 DOI: 10.1073/Pnas.042493399  0.777
2002 Tan JL, Tien J, Chen CS. Microcontact printing of proteins on mixed self-assembled monolayers Langmuir. 18: 519-523. DOI: 10.1021/La011351+  0.53
2001 Ostuni E, Chen CS, Ingber DE, Whitesides GM. Selective Deposition of Proteins and Cells in Arrays of Microwells Langmuir. 17: 2828-2834. DOI: 10.1021/La001372O  0.81
2000 Chen CS, Ostuni E, Whitesides GM, Ingber DE. Using self-assembled monolayers to pattern ECM proteins and cells on substrates. Methods in Molecular Biology (Clifton, N.J.). 139: 209-19. PMID 10840789 DOI: 10.1385/1-59259-063-2:209  0.79
2000 Ostuni E, Kane R, Chen CS, Ingber DE, Whitesides GM. Patterning mammalian cells using elastomeric membranes Langmuir. 16: 7811-7819. DOI: 10.1021/La000382M  0.795
1999 Dike LE, Chen CS, Mrksich M, Tien J, Whitesides GM, Ingber DE. Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates. In Vitro Cellular & Developmental Biology. Animal. 35: 441-8. PMID 10501083 DOI: 10.1007/S11626-999-0050-4  0.825
1999 Chen CS, Brangwynne C, Ingber DE. Pictures in cell biology: squaring up to the cell-shape debate. Trends in Cell Biology. 9: 283. PMID 10438233 DOI: 10.1016/S0962-8924(99)01551-2  0.674
1999 Chen CS, Ingber DE. Tensegrity and mechanoregulation: from skeleton to cytoskeleton. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 7: 81-94. PMID 10367017 DOI: 10.1053/Joca.1998.0164  0.637
1999 Bhatia SN, Chen CS. Tissue Engineering at the Micro-Scale Biomedical Microdevices. 2: 131-144. DOI: 10.1023/A:1009949704750  0.342
1998 Huang S, Chen CS, Ingber DE. Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Molecular Biology of the Cell. 9: 3179-93. PMID 9802905 DOI: 10.1091/Mbc.9.11.3179  0.679
1998 Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE. Micropatterned surfaces for control of cell shape, position, and function. Biotechnology Progress. 14: 356-63. PMID 9622515 DOI: 10.1021/Bp980031M  0.796
1998 Chicurel ME, Chen CS, Ingber DE. Cellular control lies in the balance of forces. Current Opinion in Cell Biology. 10: 232-9. PMID 9561847 DOI: 10.1016/S0955-0674(98)80145-2  0.639
1998 Roberts C, Chen CS, Mrksich M, Martichonok V, Ingber DE, Whitesides GM. Using mixed self-assembled monolayers presenting RGD and (EG)3OH groups to characterize long-term attachment of bovine capillary endothelial cells to surfaces Journal of the American Chemical Society. 120: 6548-6555. DOI: 10.1021/Ja972467O  0.753
1997 Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE. Geometric control of cell life and death. Science (New York, N.Y.). 276: 1425-8. PMID 9162012 DOI: 10.1126/Science.276.5317.1425  0.792
1997 Maniotis AJ, Chen CS, Ingber DE. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proceedings of the National Academy of Sciences of the United States of America. 94: 849-54. PMID 9023345 DOI: 10.1073/Pnas.94.3.849  0.641
1996 Mrksich M, Chen CS, Xia Y, Dike LE, Ingber DE, Whitesides GM. Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold. Proceedings of the National Academy of Sciences of the United States of America. 93: 10775-8. PMID 8855256 DOI: 10.1073/Pnas.93.20.10775  0.763
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