| Year |
Citation |
Score |
| 2022 |
Kitchen-Goosen SM, Schumacher H, Good J, Patterson AL, Boguslawski EA, West RA, Williams BO, Hostetter G, Agnew DW, Teixeira JM, Alberts AS. Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells. Carcinogenesis. PMID 36548952 DOI: 10.1093/carcin/bgac101 |
0.324 |
|
| 2020 |
Jeong W, Kim S, Lee U, Zhong ZA, Savitsky M, Kwon H, Kim J, Lee T, Cho JW, Williams BO, Katanaev VL, Jho EH. LDL receptor-related protein LRP6 senses nutrient levels and regulates Hippo signaling. Embo Reports. e50103. PMID 32767654 DOI: 10.15252/Embr.202050103 |
0.37 |
|
| 2020 |
Kushwaha P, Kim S, Foxa GE, Michalski MN, Williams BO, Tomlinson RE, Riddle RC. Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8. Journal of Cellular Physiology. PMID 31985040 DOI: 10.1002/Jcp.29563 |
0.381 |
|
| 2019 |
Maupin KA, Dick D, Lee J, Williams BO. Loss of Lgals3 Protects Against Gonadectomy-Induced Cortical Bone Loss in Mice. Calcified Tissue International. PMID 31745588 DOI: 10.1007/S00223-019-00630-0 |
0.341 |
|
| 2019 |
Weivoda MM, Ruan M, Hachfeld CM, Pederson L, Howe A, Davey RA, Zajac JD, Kobayashi Y, Williams BO, Westendorf JJ, Khosla S, Oursler MJ. Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 34: 1546-1548. PMID 31415114 DOI: 10.1002/Jbmr.3740 |
0.324 |
|
| 2019 |
Mirabelli CK, Nusse R, Tuveson DA, Williams BO. Perspectives on the role of Wnt biology in cancer. Science Signaling. 12. PMID 31289213 DOI: 10.1126/Scisignal.Aay4494 |
0.521 |
|
| 2019 |
Bergsma A, Ganguly SS, Wiegand ME, Dick D, Williams BO, Miranti CK. Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82. Bone Reports. 10: 100196. PMID 30788390 DOI: 10.1016/J.Bonr.2019.100196 |
0.307 |
|
| 2019 |
Stevens PD, Racette A, Tiedemann RL, Williams BO. Abstract 2628: Non-canonical Wnt signaling in late-stage PDAC Cancer Research. 79: 2628-2628. DOI: 10.1158/1538-7445.Am2019-2628 |
0.393 |
|
| 2018 |
Maupin KA, Weaver K, Bergsma A, Christie C, Zhong ZA, Yang T, Williams BO. Enhanced cortical bone expansion in -deficient mice during aging. Bone Research. 6: 7. PMID 30886760 DOI: 10.1038/S41413-017-0003-6 |
0.325 |
|
| 2018 |
Ganguly SS, Daft PG, Cao J, Meng X, Zhong ZA, Vander Ark A, Meadows A, Madaj Z, Williams B, Li X. Loss of Myeloid-Specific TGF-β Signaling Decreases CTHRC1 to Downregulate bFGF and the Development of H1993-Induced Osteolytic Bone Lesions. Cancers. 10. PMID 30469488 DOI: 10.3390/Cancers10120463 |
0.403 |
|
| 2018 |
Michalski MN, Williams BO. A quest for clarity in bone erosion: The role of sequestosome 1 in Paget's disease of bone. The Journal of Biological Chemistry. 293: 9542-9543. PMID 29907733 DOI: 10.1074/Jbc.H118.003689 |
0.362 |
|
| 2018 |
Madan B, McDonald MJ, Foxa GE, Diegel CR, Williams BO, Virshup DM. Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy. Bone Research. 6: 17. PMID 29844946 DOI: 10.1038/S41413-018-0017-8 |
0.332 |
|
| 2018 |
Bergsma A, Ganguly SS, Dick D, Williams BO, Miranti CK. Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis. Bone. PMID 29782939 DOI: 10.1016/J.Bone.2018.05.020 |
0.32 |
|
| 2018 |
Nayak G, Odaka Y, Prasad V, Solano AF, Yeo EJ, Vemaraju S, Molkentin JD, Trumpp A, Williams B, Rao S, Lang RA. Developmental vascular regression is regulated by a Wnt/β-catenin, MYC, P21 (CDKN1A) pathway that controls cell proliferation and cell death. Development (Cambridge, England). PMID 29777010 DOI: 10.1242/Dev.154898 |
0.403 |
|
| 2018 |
Lu D, Li J, Liu H, Foxa GE, Weaver K, Li J, Williams BO, Yang T. LRP1 suppresses bone resorption in mice by inhibiting the RANKL-stimulated NFκB and p38 pathways during osteoclastogenesis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 29750835 DOI: 10.1002/Jbmr.3469 |
0.374 |
|
| 2018 |
Liu H, Li J, Lu D, Li J, Liu M, He Y, Williams BO, Li J, Yang T. Ginkgolic acid, a sumoylation inhibitor, promotes adipocyte commitment but suppresses adipocyte terminal differentiation of mouse bone marrow stromal cells. Scientific Reports. 8: 2545. PMID 29416046 DOI: 10.1038/S41598-018-20244-0 |
0.314 |
|
| 2018 |
Li J, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Yang T, Zheng L. Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nature Communications. 9: 143. PMID 29321472 DOI: 10.1038/S41467-017-02413-3 |
0.459 |
|
| 2018 |
Zhong ZA, Ethen NJ, Williams BO. Recent Developments in Understanding the Role of Wnt Signaling in Skeletal Development and Disease Primer On the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 68-74. DOI: 10.1002/9781119266594.Ch9 |
0.317 |
|
| 2017 |
Valkenburg KC, De Marzo AM, Williams BO. Deletion of tumor suppressors adenomatous polyposis coli and Smad4 in murine luminal epithelial cells causes invasive prostate cancer and loss of androgen receptor expression. Oncotarget. 8: 80265-80277. PMID 29113300 DOI: 10.18632/Oncotarget.17919 |
0.36 |
|
| 2017 |
Pridgeon MG, Grohar PJ, Steensma MR, Williams BO. Wnt Signaling in Ewing Sarcoma, Osteosarcoma, and Malignant Peripheral Nerve Sheath Tumors. Current Osteoporosis Reports. PMID 28647886 DOI: 10.1007/S11914-017-0377-9 |
0.337 |
|
| 2017 |
Yang T, Williams BO. Low-Density Lipoprotein Receptor-Related Proteins in Skeletal Development and Disease. Physiological Reviews. 97: 1211-1228. PMID 28615463 DOI: 10.1152/Physrev.00013.2016 |
0.301 |
|
| 2017 |
Li J, Lu D, Liu H, Williams BO, Overbeek PA, Lee B, Zheng L, Yang T. Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling. Human Molecular Genetics. PMID 28486600 DOI: 10.1093/Hmg/Ddx183 |
0.393 |
|
| 2017 |
Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, et al. Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling. Nature. PMID 28467818 DOI: 10.1038/Nature22306 |
0.394 |
|
| 2017 |
Droscha CJ, Diegel CR, Ethen NJ, Burgers TA, McDonald MJ, Maupin KA, Naidu AS, Wang P, Teh BT, Williams BO. Osteoblast-specific deletion of Hrpt2/Cdc73 results in high bone mass and increased bone turnover. Bone. 98: 68-78. PMID 28384511 DOI: 10.1016/J.Bone.2016.12.006 |
0.371 |
|
| 2017 |
Williams BO. LRP5: From bedside to bench to bone. Bone. PMID 28341377 DOI: 10.1016/J.Bone.2017.03.044 |
0.343 |
|
| 2017 |
Walls GV, Stevenson M, Lines KE, Newey PJ, Reed AA, Bowl MR, Jeyabalan J, Harding B, Bradley KJ, Manek S, Chen J, Wang P, Williams BO, Teh BT, Thakker RV. Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome. Oncogene. PMID 28288139 DOI: 10.1038/Onc.2017.43 |
0.368 |
|
| 2017 |
Williams BO, Warman ML. CRISPR/Cas9 Technologies. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 28230927 DOI: 10.1002/Jbmr.3086 |
0.323 |
|
| 2016 |
Chin AM, Tsai YH, Finkbeiner SR, Nagy MS, Walker EM, Ethen NJ, Williams BO, Battle MA, Spence JR. A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells. Stem Cell Reports. PMID 27720905 DOI: 10.1016/J.Stemcr.2016.09.004 |
0.404 |
|
| 2016 |
Zhong ZA, Ethen NJ, Williams BO. Use of Primary Calvarial Osteoblasts to Evaluate the Function of Wnt Signaling in Osteogenesis. Methods in Molecular Biology (Clifton, N.J.). 1481: 119-25. PMID 27590158 DOI: 10.1007/978-1-4939-6393-5_13 |
0.414 |
|
| 2016 |
Schumacher CA, Joiner DM, Less KD, Drewry MO, Williams BO. Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6. Bone Research. 4: 15042. PMID 26962465 DOI: 10.1038/Boneres.2015.42 |
0.42 |
|
| 2016 |
Williams BO. Genetically engineered mouse models to evaluate the role of Wnt secretion in bone development and homeostasis. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 172: 24-6. PMID 26818176 DOI: 10.1002/Ajmg.C.31474 |
0.442 |
|
| 2016 |
Meng X, Vander Ark A, Lee P, Hostetter G, Bhowmick NA, Matrisian LM, Williams BO, Miranti CK, Li X. Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis. Oncogene. 35: 2370-8. PMID 26279296 DOI: 10.1038/Onc.2015.297 |
0.392 |
|
| 2016 |
Williams BO. Genetically engineered mouse models to evaluate the role of Wnt secretion in bone development and homeostasis American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 172: 24-26. DOI: 10.1002/ajmg.c.31474 |
0.334 |
|
| 2015 |
Rudnicki MA, Williams BO. Wnt signaling in bone and muscle. Bone. 80: 60-66. PMID 26453496 DOI: 10.1016/J.Bone.2015.02.009 |
0.317 |
|
| 2015 |
Zhong ZA, Zahatnansky J, Snider J, Van Wieren E, Diegel CR, Williams BO. Wntless spatially regulates bone development through β-catenin-dependent and independent mechanisms. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 244: 1347-55. PMID 26249818 DOI: 10.1002/Dvdy.24316 |
0.354 |
|
| 2015 |
Weivoda MM, Ruan M, Hachfeld CM, Pederson L, Howe A, Davey RA, Zajac JD, Kobayashi Y, Williams BO, Westendorf JJ, Khosla S, Oursler MJ. Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 26189772 DOI: 10.1002/Jbmr.2599 |
0.401 |
|
| 2015 |
Chen J, Huang D, Rubera I, Futami K, Wang P, Zickert P, Khoo SK, Dykema K, Zhao P, Petillo D, Cao B, Zhang Z, Si S, Schoen SR, Yang XJ, ... ... Williams BO, et al. Disruption of tubular Flcn expression as a mouse model for renal tumor induction. Kidney International. PMID 26083655 DOI: 10.1038/Ki.2015.177 |
0.342 |
|
| 2015 |
Qin L, Yin YT, Zheng FJ, Peng LX, Yang CF, Bao YN, Liang YY, Li XJ, Xiang YQ, Sun R, Li AH, Zou RH, Pei XQ, Huang BJ, Kang TB, ... ... Williams BO, et al. WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis. Oncotarget. 6: 10239-52. PMID 25823923 DOI: 10.18632/Oncotarget.3518 |
0.399 |
|
| 2015 |
Peacock JD, Dykema KJ, Toriello HV, Mooney MR, Scholten DJ, Winn ME, Borgman A, Duesbery NS, Hiemenga JA, Liu C, Campbell S, Nickoloff BP, Williams BO, Steensma M. Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations. American Journal of Medical Genetics. Part A. 167: 1429-35. PMID 25808193 DOI: 10.1002/Ajmg.A.37048 |
0.303 |
|
| 2014 |
Li C, Williams BO, Cao X, Wan M. LRP6 in mesenchymal stem cells is required for bone formation during bone growth and bone remodeling. Bone Research. 2: 14006. PMID 26273519 DOI: 10.1038/Boneres.2014.6 |
0.389 |
|
| 2014 |
Scholten DJ, Timmer CM, Peacock JD, Pelle DW, Williams BO, Steensma MR. Down regulation of Wnt signaling mitigates hypoxia-induced chemoresistance in human osteosarcoma cells. Plos One. 9: e111431. PMID 25347326 DOI: 10.1371/Journal.Pone.0111431 |
0.414 |
|
| 2014 |
Zhong Z, Ethen NJ, Williams BO. WNT signaling in bone development and homeostasis. Wiley Interdisciplinary Reviews. Developmental Biology. 3: 489-500. PMID 25270716 DOI: 10.1002/Wdev.159 |
0.34 |
|
| 2014 |
Valkenburg KC, Yu X, De Marzo AM, Spiering TJ, Matusik RJ, Williams BO. Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia. The Prostate. 74: 1506-20. PMID 25175604 DOI: 10.1002/Pros.22868 |
0.319 |
|
| 2014 |
Kabiri Z, Greicius G, Madan B, Biechele S, Zhong Z, Zaribafzadeh H, Edison, Aliyev J, Wu Y, Bunte R, Williams BO, Rossant J, Virshup DM. Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. Development (Cambridge, England). 141: 2206-15. PMID 24821987 DOI: 10.1242/Dev.104976 |
0.393 |
|
| 2014 |
Yang J, Mowry LE, Nejak-Bowen KN, Okabe H, Diegel CR, Lang RA, Williams BO, Monga SP. β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation! Hepatology (Baltimore, Md.). 60: 964-76. PMID 24700412 DOI: 10.1002/Hep.27082 |
0.364 |
|
| 2014 |
Staal B, Williams BO, Beier F, Vande Woude GF, Zhang YW. Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. Proceedings of the National Academy of Sciences of the United States of America. 111: 2590-5. PMID 24550287 DOI: 10.1073/Pnas.1400744111 |
0.35 |
|
| 2014 |
Lim WH, Liu B, Cheng D, Williams BO, Mah SJ, Helms JA. Wnt signaling regulates homeostasis of the periodontal ligament. Journal of Periodontal Research. 49: 751-9. PMID 24410666 DOI: 10.1111/Jre.12158 |
0.39 |
|
| 2014 |
Lim WH, Liu B, Cheng D, Hunter DJ, Zhong Z, Ramos DM, Williams BO, Sharpe PT, Bardet C, Mah SJ, Helms JA. Wnt signaling regulates pulp volume and dentin thickness. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 29: 892-901. PMID 23996396 DOI: 10.1002/Jbmr.2088 |
0.44 |
|
| 2013 |
Maupin KA, Droscha CJ, Williams BO. A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice. Bone Research. 1: 27-71. PMID 26273492 DOI: 10.4248/Br201301004 |
0.41 |
|
| 2013 |
Hu B, Chen Y, Usmani SZ, Ye S, Qiang W, Papanikolaou X, Heuck CJ, Yaccoby S, Williams BO, Van Rhee F, Barlogie B, Epstein J, Qiang YW. Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma. Plos One. 8: e74191. PMID 24066119 DOI: 10.1371/Journal.Pone.0074191 |
0.373 |
|
| 2013 |
Steensma MR, Tyler WK, Shaber AG, Goldring SR, Ross FP, Williams BO, Healey JH, Purdue PE. Targeting the giant cell tumor stromal cell: functional characterization and a novel therapeutic strategy. Plos One. 8: e69101. PMID 23922683 DOI: 10.1371/Journal.Pone.0069101 |
0.423 |
|
| 2013 |
Joiner DM, Less KD, Van Wieren EM, Hess D, Williams BO. Heterozygosity for an inactivating mutation in low-density lipoprotein-related receptor 6 (Lrp6) increases osteoarthritis severity in mice after ligament and meniscus injury. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 21: 1576-85. PMID 23756208 DOI: 10.1016/J.Joca.2013.05.019 |
0.365 |
|
| 2013 |
Loftus JC, Dhruv H, Tuncali S, Kloss J, Yang Z, Schumacher CA, Cao B, Williams BO, Eschbacher JM, Ross JT, Tran NL. TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance. Molecular Cancer Research : McR. 11: 865-74. PMID 23699535 DOI: 10.1158/1541-7786.Mcr-13-0008 |
0.389 |
|
| 2013 |
Burgers TA, Hoffmann MF, Collins CJ, Zahatnansky J, Alvarado MA, Morris MR, Sietsema DL, Mason JJ, Jones CB, Ploeg HL, Williams BO. Mice lacking pten in osteoblasts have improved intramembranous and late endochondral fracture healing. Plos One. 8: e63857. PMID 23675511 DOI: 10.1371/Journal.Pone.0063857 |
0.311 |
|
| 2013 |
Riddle RC, Diegel CR, Leslie JM, Van Koevering KK, Faugere MC, Clemens TL, Williams BO. Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition. Plos One. 8: e63323. PMID 23675479 DOI: 10.1371/Journal.Pone.0063323 |
0.396 |
|
| 2013 |
Burgers TA, Williams BO. Regulation of Wnt/β-catenin signaling within and from osteocytes. Bone. 54: 244-9. PMID 23470835 DOI: 10.1016/J.Bone.2013.02.022 |
0.331 |
|
| 2013 |
Ke J, Xu HE, Williams BO. Lipid modification in Wnt structure and function. Current Opinion in Lipidology. 24: 129-33. PMID 23348724 DOI: 10.1097/Mol.0B013E32835Df2Bf |
0.348 |
|
| 2013 |
Valkenburg KC, Steensma MR, Williams BO, Zhong Z. Skeletal metastasis: Treatments, mouse models, and the Wnt signaling Chinese Journal of Cancer. 32: 380-396. PMID 23327798 DOI: 10.5732/Cjc.012.10218 |
0.319 |
|
| 2013 |
Joiner DM, Ke J, Zhong Z, Xu HE, Williams BO. LRP5 and LRP6 in development and disease. Trends in Endocrinology and Metabolism: Tem. 24: 31-9. PMID 23245947 DOI: 10.1016/J.Tem.2012.10.003 |
0.319 |
|
| 2013 |
Valkenburg KC, Williams BO. Abstract C47: Assessing the role of Wnt secretion in prostate cancer skeletal metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-C47 |
0.364 |
|
| 2013 |
Valkenburg KC, Williams BO. Abstract C49: Activating Wnt/B-catenin signaling in luminal epithelial stem cells in the murine prostate induces carcinoma in situ Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-C49 |
0.355 |
|
| 2013 |
Droscha CJ, Cassandra D, Williams BO. Abstract A66: Insights into the pathogenesis of hyperparathyroidism-jaw tumor syndrome: Deciphering the role of Hrpt2 within bone development Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-A66 |
0.419 |
|
| 2013 |
Dhruv HD, Tuncali S, Kloss J, Yang Z, Schumacher C, Williams B, Ross J, Tran N, Loftus J. Abstract 2621: TNFRSF19 (TROY) promotes glioma cell survival signaling and therapeutic resistance. Cancer Research. 73: 2621-2621. DOI: 10.1158/1538-7445.Am2013-2621 |
0.397 |
|
| 2013 |
Joiner D, Less K, VanWieren E, Williams B. Mice with global deletion of mitogen inducible gene 6 display rapid and severe cartilage and subchondral bone damage after ligament and meniscus injury Osteoarthritis and Cartilage. 21: S13-S14. DOI: 10.1016/J.Joca.2013.02.049 |
0.403 |
|
| 2012 |
Regard JB, Zhong Z, Williams BO, Yang Y. Wnt signaling in bone development and disease: making stronger bone with Wnts. Cold Spring Harbor Perspectives in Biology. 4. PMID 23209148 DOI: 10.1101/Cshperspect.A007997 |
0.346 |
|
| 2012 |
Zhong Z, Williams BO. Integration of cellular adhesion and Wnt signaling: Interactions between N-cadherin and LRP5 and their role in regulating bone mass Journal of Bone and Mineral Research. 27: 1849-1851. PMID 22903578 DOI: 10.1002/Jbmr.1715 |
0.342 |
|
| 2012 |
Zhong Z, Zylstra-Diegel CR, Schumacher CA, Baker JJ, Carpenter AC, Rao S, Yao W, Guan M, Helms JA, Lane NE, Lang RA, Williams BO. Wntless functions in mature osteoblasts to regulate bone mass. Proceedings of the National Academy of Sciences of the United States of America. 109: E2197-204. PMID 22745162 DOI: 10.1073/Pnas.1120407109 |
0.365 |
|
| 2012 |
Fortin SP, Ennis MJ, Schumacher CA, Zylstra-Diegel CR, Williams BO, Ross JT, Winkles JA, Loftus JC, Symons MH, Tran NL. Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells. Molecular Cancer Research : McR. 10: 958-68. PMID 22571869 DOI: 10.1158/1541-7786.Mcr-11-0616 |
0.377 |
|
| 2012 |
Ke J, Zhang C, Harikumar KG, Zylstra-Diegel CR, Wang L, Mowry LE, Miller LJ, Williams BO, Xu HE. Modulation of β-catenin signaling by glucagon receptor activation. Plos One. 7: e33676. PMID 22438981 DOI: 10.1371/Journal.Pone.0033676 |
0.322 |
|
| 2012 |
Zhong Z, Baker JJ, Zylstra-Diegel CR, Williams BO. Lrp5 and Lrp6 play compensatory roles in mouse intestinal development. Journal of Cellular Biochemistry. 113: 31-8. PMID 21866564 DOI: 10.1002/Jcb.23324 |
0.443 |
|
| 2012 |
Proescholdt MA, Merrill MJ, Stoerr E, Lohmeier A, Brawanski A, Sim H, Hu B, Pineda CA, Yoon S, Viapiano MS, Rajappa P, Cobb WS, Huang Y, Lyden DC, Bromberg J, ... ... Williams BO, et al. LAB-ANGIOGENESIS AND INVASION Neuro-Oncology. 14: vi1-vi6. DOI: 10.1093/Neuonc/Nos219 |
0.301 |
|
| 2012 |
Li Y, Ferris A, Lewis BC, Orsulic S, Williams BO, Holland EC, Hughes SH. The RCAS/TVA somatic gene transfer method in modeling human cancer Genetically Engineered Mice For Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing. 83-111. DOI: 10.1007/978-0-387-69805-2_5 |
0.687 |
|
| 2011 |
Valkenburg KC, Graveel CR, Zylstra-Diegel CR, Zhong Z, Williams BO. Wnt/β-catenin Signaling in Normal and Cancer Stem Cells. Cancers. 3: 2050-79. PMID 24212796 DOI: 10.3390/Cancers3022050 |
0.385 |
|
| 2011 |
Joeng KS, Schumacher CA, Zylstra-Diegel CR, Long F, Williams BO. Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo. Developmental Biology. 359: 222-9. PMID 21924256 DOI: 10.1016/J.Ydbio.2011.08.020 |
0.407 |
|
| 2011 |
Stefater JA, Lewkowich I, Rao S, Mariggi G, Carpenter AC, Burr AR, Fan J, Ajima R, Molkentin JD, Williams BO, Wills-Karp M, Pollard JW, Yamaguchi T, Ferrara N, Gerhardt H, et al. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature. 474: 511-5. PMID 21623369 DOI: 10.1038/Nature10085 |
0.376 |
|
| 2011 |
Cui Y, Niziolek PJ, MacDonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, ... ... Williams BO, et al. Lrp5 functions in bone to regulate bone mass. Nature Medicine. 17: 684-91. PMID 21602802 DOI: 10.1038/Nm.2388 |
0.376 |
|
| 2011 |
Williams B. Evaluating the role(s) of Lrp5/6 and WNT ligands in regulating bone development and acquisition Bone. 48: S59-S60. DOI: 10.1016/J.Bone.2011.03.043 |
0.301 |
|
| 2010 |
Diegel CR, Cho KR, El-Naggar AK, Williams BO, Lindvall C. Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: Implications for human acinic cell carcinoma Cancer Research. 70: 9143-9152. PMID 21062985 DOI: 10.1158/0008-5472.Can-10-1758 |
0.452 |
|
| 2010 |
Mason JJ, Williams BO. SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease. Journal of Osteoporosis. 2010. PMID 20948575 DOI: 10.4061/2010/460120 |
0.349 |
|
| 2009 |
Qian CN, Furge KA, Knol J, Huang D, Chen J, Dykema KJ, Kort EJ, Massie A, Khoo SK, Vanden Beldt K, Resau JH, Anema J, Kahnoski RJ, Morreau H, Camparo P, ... ... Williams BO, et al. Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models. Cancer Research. 69: 8256-64. PMID 19843858 DOI: 10.1158/0008-5472.Can-09-1689 |
0.367 |
|
| 2009 |
Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell. 5: 279-89. PMID 19733540 DOI: 10.1016/J.Stem.2009.06.017 |
0.413 |
|
| 2009 |
Badders NM, Goel S, Clark RJ, Klos KS, Kim S, Bafico A, Lindvall C, Williams BO, Alexander CM. The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. Plos One. 4: e6594. PMID 19672307 DOI: 10.1371/Journal.Pone.0006594 |
0.413 |
|
| 2009 |
Lindvall C, Zylstra CR, Evans N, West RA, Dykema K, Furge KA, Williams BO. The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. Plos One. 4: e5813. PMID 19503830 DOI: 10.1371/Journal.Pone.0005813 |
0.432 |
|
| 2009 |
Williams BO, Insogna KL. Where Wnts went: The exploding field of Lrp5 and Lrp6 signaling in bone Journal of Bone and Mineral Research. 24: 171-178. PMID 19072724 DOI: 10.1359/Jbmr.081235 |
0.374 |
|
| 2008 |
Chen J, Futami K, Petillo D, Peng J, Wang P, Knol J, Li Y, Khoo SK, Huang D, Qian CN, Zhao P, Dykema K, Dykyma K, Zhang R, Cao B, ... ... Williams BO, et al. Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. Plos One. 3: e3581. PMID 18974783 DOI: 10.1371/Journal.Pone.0003581 |
0.391 |
|
| 2008 |
Qian Z, Chen L, Fernald AA, Williams BO, Le Beau MM. A critical role for Apc in hematopoietic stem and progenitor cell survival. The Journal of Experimental Medicine. 205: 2163-75. PMID 18725524 DOI: 10.1084/Jem.20080578 |
0.441 |
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| 2008 |
Robinson DR, Zylstra CR, Williams BO. Wnt signaling and prostate cancer Current Drug Targets. 9: 571-580. PMID 18673243 DOI: 10.2174/138945008784911831 |
0.351 |
|
| 2008 |
Shekhar MP, Gerard B, Pauley RJ, Williams BO, Tait L. Rad6B is a positive regulator of beta-catenin stabilization. Cancer Research. 68: 1741-50. PMID 18339854 DOI: 10.1158/0008-5472.Can-07-2111 |
0.31 |
|
| 2008 |
Wang P, Bowl MR, Bender S, Peng J, Farber L, Chen J, Ali A, Zhang Z, Alberts AS, Thakker RV, Shilatifard A, Williams BO, Teh BT. Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Molecular and Cellular Biology. 28: 2930-40. PMID 18212049 DOI: 10.1128/Mcb.00654-07 |
0.412 |
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| 2008 |
Wolf J, Palmby TR, Gavard J, Williams BO, Gutkind JS. Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6. Febs Letters. 582: 255-61. PMID 18083125 DOI: 10.1016/J.Febslet.2007.12.013 |
0.342 |
|
| 2008 |
Chen J, Futami K, Petillo D, Peng J, Wang P, Knol J, Li Y, Khoo S, Huang D, Qian C, Zhao P, Dykema K, Zhang R, Cao B, Yang XJ, ... ... Williams BO, et al. Correction: Deficiency of FLCN in Mouse Kidney Led to Development of Polycystic Kidneys and Renal Neoplasia Plos One. 3. DOI: 10.1371/Annotation/136385D5-B241-4Ecc-B31A-6Dea3Ebf3Bc4 |
0.329 |
|
| 2008 |
VanKoevering KK, Williams BO. Transgenic mouse strains for conditional gene deletion during skeletal development Ibms Bonekey. 5: 151-170. DOI: 10.1138/20080312 |
0.326 |
|
| 2007 |
Hinoi T, Akyol A, Theisen BK, Ferguson DO, Greenson JK, Williams BO, Cho KR, Fearon ER. Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Research. 67: 9721-30. PMID 17942902 DOI: 10.1158/0008-5472.Can-07-2735 |
0.396 |
|
| 2007 |
Lindvall C, Bu W, Williams BO, Li Y. Wnt signaling, stem cells, and the cellular origin of breast cancer Stem Cell Reviews. 3: 157-168. PMID 17873348 DOI: 10.1007/S12015-007-0025-3 |
0.449 |
|
| 2007 |
Wu R, Hendrix-Lucas N, Kuick R, Zhai Y, Schwartz DR, Akyol A, Hanash S, Misek DE, Katabuchi H, Williams BO, Fearon ER, Cho KR. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell. 11: 321-33. PMID 17418409 DOI: 10.1016/J.Ccr.2007.02.016 |
0.413 |
|
| 2007 |
Bruxvoort KJ, Charbonneau HM, Giambernardi TA, Goolsby JC, Qian CN, Zylstra CR, Robinson DR, Roy-Burman P, Shaw AK, Buckner-Berghuis BD, Sigler RE, Resau JH, Sullivan R, Bushman W, Williams BO. Inactivation of Apc in the mouse prostate causes prostate carcinoma. Cancer Research. 67: 2490-6. PMID 17363566 DOI: 10.1158/0008-5472.Can-06-3028 |
0.334 |
|
| 2007 |
Young JJ, Bromberg-White JL, Zylstra C, Church JT, Boguslawski E, Resau JH, Williams BO, Duesbery NS. LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. Plos Pathogens. 3: e27. PMID 17335347 DOI: 10.1371/Journal.Ppat.0030027 |
0.357 |
|
| 2007 |
Liu X, Bruxvoort KJ, Zylstra CR, Liu J, Cichowski R, Faugere MC, Bouxsein ML, Wan C, Williams BO, Clemens TL. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proceedings of the National Academy of Sciences of the United States of America. 104: 2259-64. PMID 17287359 DOI: 10.1073/Pnas.0604153104 |
0.426 |
|
| 2006 |
Zhang C, Kong D, Tan MH, Pappas DL, Wang PF, Chen J, Farber L, Zhang N, Koo HM, Weinreich M, Williams BO, Teh BT. Parafibromin inhibits cancer cell growth and causes G1 phase arrest. Biochemical and Biophysical Research Communications. 350: 17-24. PMID 16989776 DOI: 10.1016/J.Bbrc.2006.08.169 |
0.419 |
|
| 2006 |
Lindvall C, Evans NC, Zylstra CR, Li Y, Alexander CM, Williams BO. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. The Journal of Biological Chemistry. 281: 35081-7. PMID 16973609 DOI: 10.1074/Jbc.M607571200 |
0.485 |
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| 2006 |
Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 126: 955-68. PMID 16959574 DOI: 10.1016/J.Cell.2006.06.055 |
0.406 |
|
| 2006 |
Park KS, Jeon SH, Kim SE, Bahk YY, Holmer SL, Williams BO, Chung KC, Surh YJ, Choi KY. APC inhibits ERK pathway activation and cellular proliferation induce by RAS Journal of Cell Science. 119: 819-827. PMID 16478791 DOI: 10.1242/Jcs.02779 |
0.347 |
|
| 2005 |
Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS. Medicine: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis Science. 310: 1504-1510. PMID 16293724 DOI: 10.1126/Science.1116221 |
0.332 |
|
| 2005 |
Holmen SL, Williams BO. Essential role for Ras signaling in glioblastoma maintenance Cancer Research. 65: 8250-8255. PMID 16166301 DOI: 10.1158/0008-5472.Can-05-1173 |
0.398 |
|
| 2005 |
Ai M, Holmen SL, Van Hul W, Williams BO, Warman ML. Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Molecular and Cellular Biology. 25: 4946-55. PMID 15923613 DOI: 10.1128/Mcb.25.12.4946-4955.2005 |
0.403 |
|
| 2005 |
Holmen SL, Zylstra CR, Mukherjee A, Sigler RE, Faugere MC, Bouxsein ML, Deng L, Clemens TL, Williams BO. Essential role of beta-catenin in postnatal bone acquisition. The Journal of Biological Chemistry. 280: 21162-8. PMID 15802266 DOI: 10.1074/Jbc.M501900200 |
0.384 |
|
| 2005 |
Robertson SA, Schoumans J, Looyenga BD, Yuhas JA, Zylstra CR, Koeman JM, Swiatek PJ, Teh BT, Williams BO. Spectral karyotyping of sarcomas and fibroblasts derived from Ink4a/Arf-deficient mice reveals chromosomal instability in vitro. International Journal of Oncology. 26: 629-34. PMID 15703817 DOI: 10.3892/Ijo.26.3.629 |
0.378 |
|
| 2005 |
Holmen SL, Robertson SA, Zylstra CR, Williams BO. Wnt-independent activation of β-catenin mediated by a Dkk1-Fz5 fusion protein Biochemical and Biophysical Research Communications. 328: 533-539. PMID 15694380 DOI: 10.1016/J.Bbrc.2005.01.009 |
0.318 |
|
| 2005 |
Qian CN, Knol J, Igarashi P, Lin F, Zylstra U, Teh BT, Williams BO. Cystic renal neoplasia following conditional inactivation of Apc in mouse renal tubular epithelium Journal of Biological Chemistry. 280: 3938-3945. PMID 15550389 DOI: 10.1074/Jbc.M410697200 |
0.324 |
|
| 2005 |
Chen J, Gorman JR, Stewart V, Williams B, Jacks T, Alt FW. Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells. Current Biology : Cb. 3: 405-13. PMID 15335707 DOI: 10.1016/0960-9822(93)90347-Q |
0.686 |
|
| 2004 |
Holmen SL, Giambernardi TA, Zylstra CR, Buckner-Berghuis BD, Resau JH, Hess JF, Glatt V, Bouxsein ML, Ai M, Warman ML, Williams BO. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 19: 2033-40. PMID 15537447 DOI: 10.1359/Jbmr.040907 |
0.407 |
|
| 2004 |
Spike BT, Dirlam A, Dibling BC, Marvin J, Williams BO, Jacks T, Macleod KF. The Rb tumor suppressor is required for stress erythropoiesis. The Embo Journal. 23: 4319-29. PMID 15457215 DOI: 10.1038/Sj.Emboj.7600432 |
0.765 |
|
| 2002 |
Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO. A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. The Journal of Biological Chemistry. 277: 34727-35. PMID 12121999 DOI: 10.1074/Jbc.M204989200 |
0.355 |
|
| 2002 |
Yang H, Williams BO, Hinds PW, Shih TS, Jacks T, Bronson RT, Livingston DM. Tumor suppression by a severely truncated species of retinoblastoma protein Molecular and Cellular Biology. 22: 3103-3110. PMID 11940667 DOI: 10.1128/Mcb.22.9.3103-3110.2002 |
0.68 |
|
| 2001 |
Lipinski MM, Macleod KF, Williams BO, Mullaney TL, Crowley D, Jacks T. Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system Embo Journal. 20: 3402-3413. PMID 11432828 DOI: 10.1093/Emboj/20.13.3402 |
0.765 |
|
| 2000 |
Williams BO, Barish GD, Klymkowsky MW, Varmus HE. A comparative evaluation of beta-catenin and plakoglobin signaling activity. Oncogene. 19: 5720-8. PMID 11126358 DOI: 10.1038/Sj.Onc.1203921 |
0.614 |
|
| 2000 |
Sage J, Mulligan GJ, Attardi LD, Miller A, Chen S, Williams B, Theodorou E, Jacks T. Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization Genes and Development. 14: 3037-3050. PMID 11114892 DOI: 10.1101/Gad.843200 |
0.778 |
|
| 2000 |
Dunn KJ, Williams BO, Li Y, Pavan WJ. Neural crest-Directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development Proceedings of the National Academy of Sciences of the United States of America. 97: 10050-10055. PMID 10963668 DOI: 10.1073/Pnas.97.18.10050 |
0.482 |
|
| 1999 |
Zorn AM, Barish GD, Williams BO, Lavender P, Klymkowsky MW, Varmus HE. Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Molecular Cell. 4: 487-98. PMID 10549281 DOI: 10.1016/S1097-2765(00)80200-2 |
0.589 |
|
| 1999 |
Klymkowsky MW, Williams BO, Barish GD, Varmus HE, Vourgourakis YE. Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling. Molecular Biology of the Cell. 10: 3151-69. PMID 10512857 DOI: 10.1091/Mbc.10.10.3151 |
0.617 |
|
| 1999 |
Fisher GH, Orsulic S, Holland E, Hively WP, Li Y, Lewis BC, Williams BO, Varmus HE. Development of a flexible and specific gene delivery system for production of murine tumor models. Oncogene. 18: 5253-60. PMID 10498877 DOI: 10.1038/Sj.Onc.1203087 |
0.76 |
|
| 1998 |
Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nature Genetics. 18: 360-4. PMID 9537419 DOI: 10.1038/Ng0498-360 |
0.653 |
|
| 1996 |
Williams BO, Jacks T. Mechanisms of carcinogenesis and the mutant mouse Current Opinion in Genetics and Development. 6: 65-70. PMID 8791481 DOI: 10.1016/S0959-437X(96)90012-X |
0.668 |
|
| 1996 |
Lee MH, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T. Targeted disruption of p107: functional overlap between p107 and Rb. Genes & Development. 10: 1621-32. PMID 8682293 DOI: 10.1101/Gad.10.13.1621 |
0.783 |
|
| 1996 |
Herrera RE, Sah VP, Williams BO, Mäkelä TP, Weinberg RA, Jacks T. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts Molecular and Cellular Biology. 16: 2402-2407. PMID 8628308 DOI: 10.1128/Mcb.16.5.2402 |
0.697 |
|
| 1995 |
Tischler AS, Shih TS, Williams BO, Jacks T. Characterization of Pheochromocytomas in a Mouse Strain with a Targeted Disruptive Mutation of the Neurofibromatosis Gene Nf1. Endocrine Pathology. 6: 323-335. PMID 12114814 DOI: 10.1007/Bf02738732 |
0.681 |
|
| 1995 |
Sah VP, Attardi LD, Mulligan GJ, Williams BO, Bronson RT, Jacks T. A subset of p53-deficient embryos exhibit exencephaly Nature Genetics. 10: 175-180. PMID 7663512 DOI: 10.1038/Ng0695-175 |
0.726 |
|
| 1995 |
Tischler AS, Shih TS, Williams BO, Jacks T. Characterization of pheochromocytomas in a mouse strain with a targeted disruptive mutation of the neurofibromatosis gene Nf1 Endocrine Pathology. 6: 323-335. DOI: 10.1007/BF02738732 |
0.661 |
|
| 1994 |
Slebos RJC, Lee MH, Plunkett BS, Kessis TD, Williams BO, Jacks T, Hedrick L, Kastan MB, Cho KR. p53-Dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein Proceedings of the National Academy of Sciences of the United States of America. 91: 5320-5324. PMID 8202487 DOI: 10.1073/Pnas.91.12.5320 |
0.617 |
|
| 1994 |
Morgenbesser SD, Williams BO, Jacks T, Depinho RA. P53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens Nature. 371: 72-74. PMID 8072529 DOI: 10.1038/371072A0 |
0.671 |
|
| 1994 |
Williams BO, Remington L, Albert DM, Mukai S, Bronson RT, Jacks T. Cooperative tumorigenic effects of germline mutations in Rb and p53 Nature Genetics. 7: 480-484. PMID 7951317 DOI: 10.1038/Ng0894-480 |
0.662 |
|
| 1994 |
Williams BO, Schmitt EM, Remington L, Bronson RT, Albert DM, Weinberg RA, Jacks T. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences Embo Journal. 13: 4251-4259. PMID 7925270 DOI: 10.1002/J.1460-2075.1994.Tb06745.X |
0.738 |
|
| 1994 |
Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA. Tumor spectrum analysis in p53-mutant mice Current Biology. 4: 1-7. PMID 7922305 DOI: 10.1016/S0960-9822(00)00002-6 |
0.714 |
|
| 1994 |
Williams BO, Morgenbesser SD, DePinho RA, Jacks T. Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53 Cold Spring Harbor Symposia On Quantitative Biology. 59: 449-457. PMID 7587099 DOI: 10.1101/Sqb.1994.059.01.050 |
0.575 |
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