Year |
Citation |
Score |
2023 |
Chourey S, Wang R, Ye Q, Reddy CN, Sun S, Takenaka N, Powell WS, Rokach J. Concise Syntheses of Microsomal Metabolites of a Potent OXE (Oxoeicosanoid) Receptor Antagonist. Chemical & Pharmaceutical Bulletin. 71: 534-544. PMID 37394602 DOI: 10.1248/cpb.c22-00926 |
0.598 |
|
2022 |
Nicolaou KC, Pan S, Shelke Y, Rigol S, Bao R, Das D, Ye Q. A unified strategy for the total syntheses of eribulin and a macrolactam analogue of halichondrin B. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208938119. PMID 35930662 DOI: 10.1073/pnas.2208938119 |
0.748 |
|
2022 |
Cossette C, Chourey S, Ye Q, Reddy CN, Wang R, Poulet S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS. Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 106144. PMID 35158054 DOI: 10.1016/j.ejps.2022.106144 |
0.556 |
|
2021 |
Nicolaou KC, Pan S, Shelke Y, Ye Q, Das D, Rigol S. A Highly Convergent Total Synthesis of Norhalichondrin B. Journal of the American Chemical Society. PMID 34851106 DOI: 10.1021/jacs.1c10539 |
0.757 |
|
2021 |
Cossette C, Miller LA, Ye Q, Chourey S, Reddy CN, Rokach J, Powell WS. Targeting the oxoeicosanoid (OXE) receptor with a selective antagonist inhibits allergen-induced pulmonary inflammation in non-human primates. British Journal of Pharmacology. PMID 34766334 DOI: 10.1111/bph.15721 |
0.56 |
|
2021 |
Nicolaou KC, Pan S, Shelke Y, Das D, Ye Q, Lu Y, Sau S, Bao R, Rigol S. A Reverse Approach to the Total Synthesis of Halichondrin B. Journal of the American Chemical Society. PMID 34105959 DOI: 10.1021/jacs.1c05270 |
0.745 |
|
2021 |
Nicolaou KC, Pan S, Pulukuri KK, Ye Q, Rigol S, Erande RD, Vourloumis D, Nocek BP, Munneke S, Lyssikatos J, Valdiosera A, Gu C, Lin B, Sarvaiaya H, Trinidad J, et al. Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis. The Journal of Organic Chemistry. PMID 33544599 DOI: 10.1021/acs.joc.0c02755 |
0.706 |
|
2019 |
Ye Q, Chourey S, Reddy CN, Wang R, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS. Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys. British Journal of Pharmacology. PMID 31655025 DOI: 10.1111/Bph.14874 |
0.626 |
|
2019 |
Miller LA, Cossette C, Chourey S, Ye Q, Reddy CN, Rokach J, Powell WS. Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid (OXE) receptor antagonist in nonhuman primates. British Journal of Pharmacology. PMID 31655023 DOI: 10.1111/Bph.14872 |
0.568 |
|
2018 |
Chourey S, Ye Q, Reddy CN, Wang R, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS. Novel highly potent and metabolically resistant oxoeicosanoid (OXE) receptor antagonists that block the actions of the granulocyte chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE). Journal of Medicinal Chemistry. PMID 29972644 DOI: 10.1021/Acs.Jmedchem.8B00154 |
0.635 |
|
2018 |
Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS. Corrigendum to "In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys" [Biochem. Pharmacol. 138 (2017) 107-118]. Biochemical Pharmacology. 154: 174. PMID 29754018 DOI: 10.1016/J.Bcp.2018.04.025 |
0.584 |
|
2018 |
Reddy CN, Alhamza H, Chourey S, Ye Q, Gore V, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS. Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 29339225 DOI: 10.1016/J.Ejps.2018.01.021 |
0.736 |
|
2017 |
Ye Q, Chourey S, Wang R, Chintam NR, Gravel S, Powell WS, Rokach J. Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 28943042 DOI: 10.1016/J.Bmcl.2017.08.034 |
0.639 |
|
2017 |
Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS. In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys. Biochemical Pharmacology. PMID 28476332 DOI: 10.1016/J.Bcp.2017.04.031 |
0.608 |
|
2017 |
Nagendra Reddy C, Ye Q, Patel P, Sivendran S, Chourey S, Wang R, Anumolu JR, Grant GE, Powell WS, Rokach J. Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase. Bioorganic & Medicinal Chemistry. 25: 116-125. PMID 28340986 DOI: 10.1016/J.Bmc.2016.10.017 |
0.762 |
|
2016 |
Cossette C, Chourey S, Ye Q, Nagendra Reddy C, Gore V, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS. Pharmacokinetics and metabolism of selective oxoeicosanoid (OXE) receptor antagonists and their effects on 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE)-induced granulocyte activation in monkeys. Journal of Medicinal Chemistry. PMID 27766872 DOI: 10.1021/Acs.Jmedchem.6B00895 |
0.751 |
|
2015 |
Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie JP, Reinero CR, Rokach J, Powell WS. Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. Biochemical Pharmacology. 96: 247-55. PMID 26032638 DOI: 10.1016/J.Bcp.2015.05.009 |
0.727 |
|
2015 |
Nagendra Reddy C, Ye Q, Chourey S, Gravel S, Powell WS, Rokach J. Stereoselective synthesis of two highly potent 5-oxo-ETE receptor antagonists Tetrahedron Letters. 56: 6896-6899. DOI: 10.1016/J.Tetlet.2015.10.097 |
0.628 |
|
2014 |
Patel P, Reddy CN, Gore V, Chourey S, Ye Q, Ouedraogo YP, Gravel S, Powell WS, Rokach J. Two Potent OXE-R Antagonists: Assignment of Stereochemistry. Acs Medicinal Chemistry Letters. 5: 815-9. PMID 25050171 DOI: 10.1021/Ml500161V |
0.773 |
|
2014 |
Gore V, Chourey S, Ye Q, Patel P, Ouedraogo Y, Gravel S, Powell WS, Rokach J. Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 3385-8. PMID 24948567 DOI: 10.1016/J.Bmcl.2014.05.090 |
0.748 |
|
2014 |
Gore V, Gravel S, Cossette C, Patel P, Chourey S, Ye Q, Rokach J, Powell WS. Inhibition of 5-oxo-6,8,11,14-eicosatetraenoic acid-induced activation of neutrophils and eosinophils by novel indole OXE receptor antagonists. Journal of Medicinal Chemistry. 57: 364-77. PMID 24351031 DOI: 10.1021/Jm401292M |
0.765 |
|
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