Vishwanath Rao Lingappa, MD PhD - Publications

Physiology and Medicine University of California, San Francisco, San Francisco, CA 
secretory pathway, cell biology, prions, cell-free systems

90 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Reed JC, Solas D, Kitaygorodskyy A, Freeman B, Ressler DTB, Phuong DJ, Swain JV, Matlack K, Hurt CR, Lingappa VR, Lingappa JR. Identification of an antiretroviral small molecule that appears to be a host-targeting inhibitor of HIV-1 assembly. Journal of Virology. PMID 33148797 DOI: 10.1128/JVI.00883-20  0.44
2018 Reed JC, Westergreen N, Barajas BC, Ressler DTB, Phuong DJ, Swain JV, Lingappa VR, Lingappa JR. The formation of RNA granule-derived capsid assembly intermediates appears to be conserved between HIV-1 and the non-primate lentivirus FIV. Journal of Virology. PMID 29467316 DOI: 10.1128/JVI.01761-17  0.44
2014 Marreiros R, Müller-Schiffmann A, Bader V, Selvarajah S, Dey D, Lingappa VR, Korth C. Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets. Virus Research. PMID 25451064 DOI: 10.1016/j.virusres.2014.10.003  0.96
2013 Spurgers KB, Hurt CR, Cohen JW, Eccelston LT, Lind CM, Lingappa VR, Glass PJ. Validation of a cell-based ELISA as a screening tool identifying anti-alphavirus small-molecule inhibitors. Journal of Virological Methods. 193: 226-31. PMID 23764417 DOI: 10.1016/j.jviromet.2013.06.007  0.96
2013 Lingappa UF, Wu X, Macieik A, Yu SF, Atuegbu A, Corpuz M, Francis J, Nichols C, Calayag A, Shi H, Ellison JA, Harrell EK, Asundi V, Lingappa JR, Prasad MD, ... ... Lingappa VR, et al. Host-rabies virus protein-protein interactions as druggable antiviral targets. Proceedings of the National Academy of Sciences of the United States of America. 110: E861-8. PMID 23404707 DOI: 10.1073/pnas.1210198110  0.96
2013 Lingappa VR, Hurt CR, Garvey E. Capsid assembly as a point of intervention for novel anti-viral therapeutics. Current Pharmaceutical Biotechnology. 14: 513-23. PMID 22429134  0.96
2012 Choi SY, Fogelgren B, Zuo X, Huang L, McKenna S, Lingappa VR, Lipschutz JH. Exocyst Sec10 is involved in basolateral protein translation and translocation in the endoplasmic reticulum. Nephron. Experimental Nephrology. 120: e134-40. PMID 23037926 DOI: 10.1159/000342366  0.96
2011 Hurt CR, Lingappa VR, Hansen WJ. The Emergence of Small-Molecule Inhibitors of Capsid Assembly as Potential Antiviral Therapeutics Annual Reports in Medicinal Chemistry. 46: 283-297. DOI: 10.1016/B978-0-12-386009-5.00010-2  0.96
2010 Liu J, Akhavan A, Lu M, Gruzman A, Lingappa VR, An J, Bowser R. Carbonic anhydrase I is recognized by an SOD1 antibody upon biotinylation of human spinal cord extracts. International Journal of Molecular Sciences. 11: 4051-62. PMID 21152319 DOI: 10.3390/ijms11104051  0.96
2010 Lutz J, Brabeck C, Niemann HH, Kloz U, Korth C, Lingappa VR, Bürkle A. Microdeletions within the hydrophobic core region of cellular prion protein alter its topology and metabolism. Biochemical and Biophysical Research Communications. 393: 439-44. PMID 20138835 DOI: 10.1016/j.bbrc.2010.02.015  0.96
2008 Akhavan A, Crivelli SN, Singh M, Lingappa VR, Muschler JL. SEA domain proteolysis determines the functional composition of dystroglycan. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 612-21. PMID 17905726 DOI: 10.1096/fj.07-8354com  0.96
2008 Boden G, Scapa EF, Kanno K, Cohen DE, Brosnan ME, Brosnan JT, Pessayre D, Roy-Chowdhury N, Lu Y, Roy-Chowdhury J, Jansen PLM, Faber KN, Häussinger D, Lingappa VR, Fernández-Checa JC, et al. Metabolism Textbook of Hepatology: From Basic Science to Clinical Practice, Third Edition. 129-249. DOI: 10.1002/9780470691861.ch2c  0.96
2007 Gruzman A, Wood WL, Alpert E, Prasad MD, Miller RG, Rothstein JD, Bowser R, Hamilton R, Wood TD, Cleveland DW, Lingappa VR, Liu J. Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 104: 12524-9. PMID 17636119 DOI: 10.1073/pnas.0705044104  0.96
2007 Karpuj MV, Giles K, Gelibter-Niv S, Scott MR, Lingappa VR, Szoka FC, Peretz D, Denetclaw W, Prusiner SB. Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells. Molecular Medicine (Cambridge, Mass.). 13: 190-8. PMID 17592554 DOI: 10.2119/2006–00073.Karpuj  0.96
2007 Ott CM, Akhavan A, Lingappa VR. Specific features of the prion protein transmembrane domain regulate nascent chain orientation. The Journal of Biological Chemistry. 282: 11163-71. PMID 17276986 DOI: 10.1074/jbc.M607660200  0.96
2006 Marzi A, Akhavan A, Simmons G, Gramberg T, Hofmann H, Bates P, Lingappa VR, Pöhlmann S. The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNR. Journal of Virology. 80: 6305-17. PMID 16775318 DOI: 10.1128/JVI.02545-05  0.96
2005 Lingappa VR, Lingappa JR. Recent insights into biological regulation from cell-free protein-synthesizing systems. The Mount Sinai Journal of Medicine, New York. 72: 141-60. PMID 15915309  0.96
2004 Ott CM, Lingappa VR. Signal sequences influence membrane integration of the prion protein. Biochemistry. 43: 11973-82. PMID 15379537 DOI: 10.1021/bi049156s  0.96
2003 Rutkowski DT, Ott CM, Polansky JR, Lingappa VR. Signal sequences initiate the pathway of maturation in the endoplasmic reticulum lumen. The Journal of Biological Chemistry. 278: 30365-72. PMID 12771148 DOI: 10.1074/jbc.M302117200  0.96
2003 Lipschutz JH, Lingappa VR, Mostov KE. The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum. The Journal of Biological Chemistry. 278: 20954-60. PMID 12665531 DOI: 10.1074/jbc.M213210200  0.96
2002 Bose HS, Lingappa VR, Miller WL. The steroidogenic acute regulatory protein, StAR, works only at the outer mitochondrial membrane. Endocrine Research. 28: 295-308. PMID 12530629 DOI: 10.1081/ERC-120016800  0.96
2002 Lingappa VR, Rutkowski DT, Hegde RS, Andersen OS. Conformational control through translocational regulation: a new view of secretory and membrane protein folding. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 24: 741-8. PMID 12210535 DOI: 10.1002/bies.10130  0.96
2002 Ott CM, Lingappa VR. Integral membrane protein biosynthesis: why topology is hard to predict. Journal of Cell Science. 115: 2003-9. PMID 11973342  0.96
2001 Rutkowski DT, Lingappa VR, Hegde RS. Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequences. Proceedings of the National Academy of Sciences of the United States of America. 98: 7823-8. PMID 11416167 DOI: 10.1073/pnas.141125098  0.96
1999 Hegde RS, Tremblay P, Groth D, DeArmond SJ, Prusiner SB, Lingappa VR. Transmissible and genetic prion diseases share a common pathway of neurodegeneration. Nature. 402: 822-6. PMID 10617204 DOI: 10.1038/45574  0.96
1999 Zimmerman CC, Lingappa VR, Richards JE, Rozsa FW, Lichter PR, Polansky JR. A trabecular meshwork glucocorticoid response (TIGR) gene mutation affects translocational processing. Molecular Vision. 5: 19. PMID 10459044  0.96
1999 Hegde RS, Lingappa VR. Regulation of protein biogenesis at the endoplasmic reticulum membrane. Trends in Cell Biology. 9: 132-7. PMID 10203789 DOI: 10.1016/S0962-8924(99)01504-4  0.96
1998 Hegde RS, Voigt S, Lingappa VR. Regulation of protein topology by trans-acting factors at the endoplasmic reticulum. Molecular Cell. 2: 85-91. PMID 9702194  0.96
1998 Rusiñol AE, Hegde RS, Chuck SL, Lingappa VR, Vance JE. Translocational pausing of apolipoprotein B can be regulated by membrane lipid composition. Journal of Lipid Research. 39: 1287-94. PMID 9643361  0.96
1998 Hegde RS, Voigt S, Rapoport TA, Lingappa VR. TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum. Cell. 92: 621-31. PMID 9506517 DOI: 10.1016/S0092-8674(00)81130-7  0.96
1998 Hegde RS, Mastrianni JA, Scott MR, DeFea KA, Tremblay P, Torchia M, DeArmond SJ, Prusiner SB, Lingappa VR. A transmembrane form of the prion protein in neurodegenerative disease. Science (New York, N.Y.). 279: 827-34. PMID 9452375 DOI: 10.1126/science.279.5352.827  0.96
1997 Hegde RS, Lingappa VR. Membrane protein biogenesis: regulated complexity at the endoplasmic reticulum. Cell. 91: 575-82. PMID 9393851  0.96
1997 Kivlen MH, Dorsey CA, Lingappa VR, Hegde RS. Asymmetric distribution of pause transfer sequences in apolipoprotein B-100. Journal of Lipid Research. 38: 1149-62. PMID 9215543  0.96
1996 Hegde RS, Lingappa VR. Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol. Cell. 85: 217-28. PMID 8612274 DOI: 10.1016/S0092-8674(00)81098-3  0.96
1994 Nakahara DH, Lingappa VR, Chuck SL. Translocational pausing is a common step in the biogenesis of unconventional integral membrane and secretory proteins. The Journal of Biological Chemistry. 269: 7617-22. PMID 8125986  0.96
1994 Hansen WJ, Lingappa VR, Welch WJ. Complex environment of nascent polypeptide chains. The Journal of Biological Chemistry. 269: 26610-3. PMID 7929390  0.96
1994 De Fea KA, Nakahara DH, Calayag MC, Yost CS, Mirels LF, Prusiner SB, Lingappa VR. Determinants of carboxyl-terminal domain translocation during prion protein biogenesis. The Journal of Biological Chemistry. 269: 16810-20. PMID 7911469  0.96
1994 Skach WR, Lingappa VR. Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1). Cancer Research. 54: 3202-9. PMID 7911395  0.96
1994 Lingappa JR, Martin RL, Wong ML, Ganem D, Welch WJ, Lingappa VR. A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle. The Journal of Cell Biology. 125: 99-111. PMID 7908022  0.96
1994 Skach WR, Shi LB, Calayag MC, Frigeri A, Lingappa VR, Verkman AS. Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum. The Journal of Cell Biology. 125: 803-15. PMID 7514605 DOI: 10.1083/jcb.125.4.803  0.96
1993 Small DM, Chiang J, Davis R, Javitt N, Vlahcevic R, Lange Y, Levy D, Stolz A, Carey M, Hamilton RL, Lingappa V, Olofsson SO, Kern F, Rudel L, Deitschy J, et al. 1992 Aspen Bile Acid/Cholesterol/Lipoprotein Conference. Report of a conference Journal of Lipid Research. 34: 680-687. PMID 8496673  0.96
1993 Chuck SL, Lingappa VR. Analysis of a pause transfer sequence from apolipoprotein B. The Journal of Biological Chemistry. 268: 22794-801. PMID 8226789  0.96
1993 Skach WR, Calayag MC, Lingappa VR. Evidence for an alternate model of human P-glycoprotein structure and biogenesis. The Journal of Biological Chemistry. 268: 6903-8. PMID 8096508  0.96
1993 Skach WR, Lingappa VR. Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences. The Journal of Biological Chemistry. 268: 23552-61. PMID 7901209  0.96
1992 Chuck SL, Lingappa VR. Apolipoprotein B intermediates. Nature. 356: 115-6. PMID 1545861 DOI: 10.1038/356115b0  0.96
1992 Chuck SL, Lingappa VR. Pause transfer: a topogenic sequence in apolipoprotein B mediates stopping and restarting of translocation. Cell. 68: 9-21. PMID 1370657 DOI: 10.1016/0092-8674(92)90202-N  0.96
1992 Dorsey CA, Lingappa VR. Cotranslational and posttranslational control of early steps in protein biogenesis: implications for the liver. Progress in Liver Diseases. 10: 25-46. PMID 1296233  0.96
1992 Hasegawa H, Skach W, Baker O, Calayag MC, Lingappa V, Verkman AS. A multifunctional aqueous channel formed by CFTR. Science (New York, N.Y.). 258: 1477-9. PMID 1279809  0.96
1991 Frey BM, Frey FJ, Lingappa VR, Trachsel H. Expression of human recombinant lipocortin I in a wheat-germ cell-free system and Xenopus oocytes. Lipocortin is not secreted. The Biochemical Journal. 275: 219-25. PMID 1826832  0.96
1991 Lingappa VR. Control of protein topology at the endoplasmic reticulum. Cell Biophysics. 19: 1-15. PMID 1726880 DOI: 10.1007/BF02989874  0.96
1991 Lingappa VR. More than just a channel: provocative new features of protein traffic across the ER membrane. Cell. 65: 527-30. PMID 1709589 DOI: 10.1016/0092-8674(91)90081-9  0.96
1990 Chuck SL, Yao Z, Blackhart BD, McCarthy BJ, Lingappa VR. New variation on the translocation of proteins during early biogenesis of apolipoprotein B. Nature. 346: 382-5. PMID 2374610 DOI: 10.1038/346382a0  0.96
1990 Eble BE, Lingappa VR, Ganem D. The N-terminal (pre-S2) domain of a hepatitis B virus surface glycoprotein is translocated across membranes by downstream signal sequences. Journal of Virology. 64: 1414-9. PMID 2304150  0.96
1990 Lopez CD, Yost CS, Prusiner SB, Myers RM, Lingappa VR. Unusual topogenic sequence directs prion protein biogenesis. Science (New York, N.Y.). 248: 226-9. PMID 1970195  0.96
1990 Yost CS, Lopez CD, Prusiner SB, Myers RM, Lingappa VR. Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein. Nature. 343: 669-72. PMID 1968226 DOI: 10.1038/343669a0  0.96
1989 Lingappa VR. Intracellular traffic of newly synthesized proteins. Current understanding and future prospects. The Journal of Clinical Investigation. 83: 739-51. PMID 2646317 DOI: 10.1172/JCI113952  0.96
1989 Andrews DW, Lauffer L, Walter P, Lingappa VR. Evidence for a two-step mechanism involved in assembly of functional signal recognition particle receptor. The Journal of Cell Biology. 108: 797-810. PMID 2537835  0.96
1988 Simon K, Lingappa VR, Ganem D. A block to the intracellular transport and assembly of hepatitis B surface antigen polypeptides in Xenopus oocytes. Virology. 166: 76-81. PMID 3413987 DOI: 10.1016/0042-6822(88)90148-1  0.96
1988 Simon K, Lingappa VR, Ganem D. Secreted hepatitis B surface antigen polypeptides are derived from a transmembrane precursor. The Journal of Cell Biology. 107: 2163-8. PMID 3198683  0.96
1988 Moessner J, Okabayashi Y, Perara E, Logsdon CD, Lingappa VR, Williams JA. Synthesis and secretion of rat pancreatic proteins by Xenopus laevis oocytes. Pancreas. 3: 499-507. PMID 3186682  0.96
1988 Andrews DW, Perara E, Lesser C, Lingappa VR. Sequences beyond the cleavage site influence signal peptide function. The Journal of Biological Chemistry. 263: 15791-8. PMID 3170612  0.96
1988 McKinley MP, Lingappa VR, Prusiner SB. Developmental regulation of prion protein mRNA in brain. Ciba Foundation Symposium. 135: 101-16. PMID 2900716  0.96
1988 Williams JA, McChesney DJ, Calayag MC, Lingappa VR, Logsdon CD. Expression of receptors for cholecystokinin and other Ca2+-mobilizing hormones in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 85: 4939-43. PMID 2898786  0.96
1988 Rothman RE, Andrews DW, Calayag MC, Lingappa VR. Construction of defined polytopic integral transmembrane proteins. The role of signal and stop transfer sequence permutations. The Journal of Biological Chemistry. 263: 10470-80. PMID 2839492  0.96
1987 Eble BE, MacRae DR, Lingappa VR, Ganem D. Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen. Molecular and Cellular Biology. 7: 3591-601. PMID 3683395  0.96
1987 Faust PL, Wall DA, Perara E, Lingappa VR, Kornfeld S. Expression of human cathepsin D in Xenopus oocytes: phosphorylation and intracellular targeting. The Journal of Cell Biology. 105: 1937-45. PMID 3680368  0.96
1987 McKinley MP, Hay B, Lingappa VR, Lieberburg I, Prusiner SB. Developmental expression of prion protein gene in brain. Developmental Biology. 121: 105-10. PMID 3569656 DOI: 10.1016/0012-1606(87)90143-6  0.96
1987 Simon K, Perara E, Lingappa VR. Translocation of globin fusion proteins across the endoplasmic reticulum membrane in Xenopus laevis oocytes. The Journal of Cell Biology. 104: 1165-72. PMID 3553206  0.96
1987 Hay B, Barry RA, Lieberburg I, Prusiner SB, Lingappa VR. Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]. Molecular and Cellular Biology. 7: 914-20. PMID 3547085  0.96
1987 Hay B, Prusiner SB, Lingappa VR. Evidence for a secretory form of the cellular prion protein. Biochemistry. 26: 8110-5. PMID 3126796  0.96
1986 Perara E, Rothman RE, Lingappa VR. Uncoupling translocation from translation: implications for transport of proteins across membranes. Science (New York, N.Y.). 232: 348-52. PMID 3961485  0.96
1986 Mize NK, Andrews DW, Lingappa VR. A stop transfer sequence recognizes receptors for nascent chain translocation across the endoplasmic reticulum membrane. Cell. 47: 711-9. PMID 3096576 DOI: 10.1016/0092-8674(86)90514-3  0.96
1986 Walter P, Lingappa VR. Mechanism of protein translocation across the endoplasmic reticulum membrane. Annual Review of Cell Biology. 2: 499-516. PMID 3030381 DOI: 10.1146/annurev.cb.02.110186.002435  0.96
1986 Eble BE, Lingappa VR, Ganem D. Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide. Molecular and Cellular Biology. 6: 1454-63. PMID 3023891  0.96
1986 Bray PF, Rosa JP, Lingappa VR, Kan YW, McEver RP, Shuman MA. Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa. Proceedings of the National Academy of Sciences of the United States of America. 83: 1480-4. PMID 3006053  0.96
1985 Perara E, Lingappa VR. A former amino terminal signal sequence engineered to an internal location directs translocation of both flanking protein domains. The Journal of Cell Biology. 101: 2292-301. PMID 3864782  0.96
1984 Lingappa VR, Chaidez J, Yost CS, Hedgpeth J. Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes. Proceedings of the National Academy of Sciences of the United States of America. 81: 456-60. PMID 6607473  0.96
1983 Yost CS, Hedgpeth J, Lingappa VR. A stop transfer sequence confers predictable transmembrane orientation to a previously secreted protein in cell-free systems. Cell. 34: 759-66. PMID 6313206 DOI: 10.1016/0092-8674(83)90532-9  0.96
1980 Lingappa VR, Blobel G. Early events in the biosynthesis of secretory and membrane proteins: the signal hypothesis. Recent Progress in Hormone Research. 36: 451-75. PMID 6997945  0.96
1980 Lingappa VR, Lingappa JR, Blobel G. Signal sequences for early events in protein secretion and membrane assembly. Annals of the New York Academy of Sciences. 343: 356-61. PMID 6994554  0.96
1980 McCune JM, Lingappa VR, Fu SM, Blobel G, Kunkel HG. Biogenesis of membrane-bound and secreted immunoglobulins. I. Two distinct translation products of human mu-chain, with identical N-termini and different C-termini. The Journal of Experimental Medicine. 152: 463-8. PMID 6772735  0.96
1979 Blobel G, Walter P, Chang CN, Goldman BM, Erickson AH, Lingappa VR. Translocation of proteins across membranes: the signal hypothesis and beyond. Symposia of the Society For Experimental Biology. 33: 9-36. PMID 524275  0.96
1979 Lingappa VR, Lingappa JR, Blobel G. Chicken ovalbumin contains an internal signal sequence. Nature. 281: 117-21. PMID 471058 DOI: 10.1038/281117a0  0.96
1979 Walter P, Jackson RC, Marcus MM, Lingappa VR, Blobel G. Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proceedings of the National Academy of Sciences of the United States of America. 76: 1795-9. PMID 109833 DOI: 10.1073/pnas.76.4.1795  0.96
1979 Lingappa VR, Cunningham BA, Jazwinski SM, Hopp TP, Blobel G, Edelman GM. Cell-free synthesis and segregation of beta 2-microglobulin. Proceedings of the National Academy of Sciences of the United States of America. 76: 3651-5. PMID 91168  0.96
1978 Lingappa VR, Shields D, Woo SL, Blobel G. Nascent chicken ovalbumin contains the functional equivalent of a signal sequence. The Journal of Cell Biology. 79: 567-72. PMID 569160  0.96
1978 Lingappa VR, Lingappa JR, Prasad R, Ebner KE, Blobel G. Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein. Proceedings of the National Academy of Sciences of the United States of America. 75: 2338-42. PMID 276877  0.96
1978 Lingappa VR, Katz FN, Lodish HF, Blobel G. A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function. The Journal of Biological Chemistry. 253: 8667-70. PMID 214427  0.96
1977 Lingappa VR, Devillers-Thiery A, Blobel G. Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin. Proceedings of the National Academy of Sciences of the United States of America. 74: 2432-6. PMID 267936  0.96
1977 Katz FN, Rothman JE, Lingappa VR, Blobel G, Lodish HF. Membrane assembly in vitro: synthesis, glycosylation, and asymmetric insertion of a transmembrane protein. Proceedings of the National Academy of Sciences of the United States of America. 74: 3278-82. PMID 198778 DOI: 10.1073/pnas.74.8.3278  0.96
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