| Year |
Citation |
Score |
| 2023 |
Sharma S, Chung CY, Uryu S, Petrovic J, Cao J, Rickard A, Nady N, Greasley S, Johnson E, Brodsky O, Khan S, Wang H, Wang Z, Zhang Y, Tsaparikos K, ... ... Street IP, et al. Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer. Cell Chemical Biology. PMID 37557181 DOI: 10.1016/j.chembiol.2023.07.005 |
0.644 |
|
| 2021 |
Grohmann C, Walker F, Devlin M, Luo MX, Chüeh AC, Doherty J, Vaillant F, Ho GY, Wakefield MJ, Weeden CE, Kamili A, Murray J, Po'uha ST, Weinstock J, Kane SR, ... ... Street I, et al. Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors. Cell Death & Disease. 12: 268. PMID 33712556 DOI: 10.1038/s41419-020-03269-0 |
0.645 |
|
| 2020 |
Priebbenow DL, Leaver D, Nguyen N, Cleary B, Lagiakos HR, Sanchez J, Xue L, Huang F, Sun Y, Mujumdar P, Mudududdla R, Varghese S, Teguh SC, Charman SA, White KL, ... ... Street IP, et al. Discovery of Acylsulfonohydrazide-Derived Lysine Acetyltransferase (KAT6A) Inhibitors as Potent Senescence-Inducing Anti-Cancer Agents. Journal of Medicinal Chemistry. PMID 32118427 DOI: 10.1021/Acs.Jmedchem.9B02071 |
0.411 |
|
| 2019 |
MacPherson L, Anokye J, Yeung MM, Lam EYN, Chan YC, Weng CF, Yeh P, Knezevic K, Butler MS, Hoegl A, Chan KL, Burr ML, Gearing LJ, Willson T, Liu J, ... ... Street IP, et al. HBO1 is required for the maintenance of leukaemia stem cells. Nature. PMID 31827282 DOI: 10.1038/S41586-019-1835-6 |
0.368 |
|
| 2019 |
AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, Brajanovski N, Smith LK, Rao AD, Lelliott EJ, Kleinschmidt M, ... ... Street I, et al. Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 31439820 DOI: 10.1073/Pnas.1901323116 |
0.412 |
|
| 2019 |
Leaver D, Cleary B, Nguyen NT, Priebbenow DL, Lagiakos HR, Sanchez J, Xue L, Huang F, Sun Y, Mujumdar P, Mudududdla R, Varghese S, Teguh S, Charman SA, White K, ... ... Street I, et al. Discovery of benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A. Journal of Medicinal Chemistry. PMID 31256587 DOI: 10.2210/Pdb6Oio/Pdb |
0.384 |
|
| 2018 |
Baell JB, Leaver DJ, Hermans SJ, Kelly GL, Brennan MS, Downer NL, Nguyen N, Wichmann J, McRae HM, Yang Y, Cleary B, Lagiakos HR, Mieruszynski S, Pacini G, Vanyai HK, ... ... Street IP, et al. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature. PMID 30069049 DOI: 10.1038/S41586-018-0387-5 |
0.391 |
|
| 2018 |
Sonderegger S, Cerruti L, Tremblay C, Toulmin E, Saw J, Nebl T, Hannan KM, Lane SW, Falk H, Unnikrishnan A, Stupple P, Street I, Jane S, Altura R, Nicholson B, et al. Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms Blood. 132: 53-53. DOI: 10.1182/Blood-2018-99-118406 |
0.424 |
|
| 2018 |
Toulmin E, Sonderegger S, Cerruti L, Terzic A, Yan F, Wong N, Street I, Stupple P, Jane S, Wei AH, Altura R, Nicholson B, Curtis DJ. PRMT5 Inhibition Selectively Targets Acute Myeloid Leukemia Stem Cells Though a p53-Dependent Mechanism Blood. 132: 4061-4061. DOI: 10.1182/Blood-2018-99-117835 |
0.363 |
|
| 2015 |
Cursons J, Leuchowius KJ, Waltham M, Tomaskovic-Crook E, Foroutan M, Bracken CP, Redfern A, Crampin EJ, Street I, Davis MJ, Thompson EW. Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines. Cell Communication and Signaling : Ccs. 13: 26. PMID 25975820 DOI: 10.1186/S12964-015-0106-X |
0.337 |
|
| 2015 |
Cursons J, Leuchowius K, Waltham M, Tomaskovic-Crook E, Foroutan M, Bracken CP, Redfern A, Crampin EJ, Street I, Davis MJ, Thompson EW. Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines F1000research. 4. DOI: 10.7490/F1000Research.1110933.1 |
0.314 |
|
| 2015 |
Falk H, Foitzik RC, Allan E, deSilva M, Yang H, Bozikis YE, Nikac M, Walker SR, Camerino MA, Morrow BJ, Stupple AE, Lagiakos R, Pinson J, Lessene R, Kersten WJA, ... ... Street IP, et al. Abstract 5371: PRMT5 inhibitors as novel treatment for cancers Cancer Research. 75: 5371-5371. DOI: 10.1158/1538-7445.Am2015-5371 |
0.452 |
|
| 2014 |
Brady RM, Vom A, Roy MJ, Toovey N, Smith BJ, Moss RM, Hatzis E, Huang DC, Parisot JP, Yang H, Street IP, Colman PM, Czabotar PE, Baell JB, Lessene G. De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization. Journal of Medicinal Chemistry. 57: 1323-43. PMID 24456288 DOI: 10.1021/Jm401948B |
0.35 |
|
| 2014 |
Leske A, Foitzik R, Beaumont D, Bentley J, Bergman Y, Brown C, Camerino M, Charman S, Choi N, Silva MD, Chung M, Falk H, Ganame D, Gregg A, Grusovin J, ... ... Street I, et al. Abstract 4029: BL-011256 is a novel VEGFR3 selective inhibitor, which suppresses tumor lymphatics and lymph node metastasis in an animal model of melanoma Cancer Research. 74: 4029-4029. DOI: 10.1158/1538-7445.Am2014-4029 |
0.337 |
|
| 2013 |
Sleebs BE, Kersten WJ, Kulasegaram S, Nikolakopoulos G, Hatzis E, Moss RM, Parisot JP, Yang H, Czabotar PE, Fairlie WD, Lee EF, Adams JM, Chen L, van Delft MF, Lowes KN, ... ... Street IP, et al. Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. Journal of Medicinal Chemistry. 56: 5514-40. PMID 23767404 DOI: 10.1021/Jm400556W |
0.411 |
|
| 2013 |
Zhang L, Holmes IP, Hochgräfe F, Walker SR, Ali NA, Humphrey ES, Wu J, de Silva M, Kersten WJ, Connor T, Falk H, Allan L, Street IP, Bentley JD, Pilling PA, et al. Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. Journal of Proteome Research. 12: 3104-16. PMID 23692254 DOI: 10.1021/Pr3008495 |
0.33 |
|
| 2013 |
Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KN, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJ, Kulasegaram S, Moss RM, ... ... Street IP, et al. Structure-guided design of a selective BCL-X(L) inhibitor. Nature Chemical Biology. 9: 390-7. PMID 23603658 DOI: 10.1038/Nchembio.1246 |
0.329 |
|
| 2013 |
Li R, Doherty J, Antonipillai J, Chen S, Devlin M, Visser K, Baell J, Street I, Anderson RL, Bernard O. LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice. Clinical & Experimental Metastasis. 30: 483-95. PMID 23239465 DOI: 10.1007/S10585-012-9553-6 |
0.403 |
|
| 2013 |
Willoughby LF, Schlosser T, Manning SA, Parisot JP, Street IP, Richardson HE, Humbert PO, Brumby AM. An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery. Disease Models & Mechanisms. 6: 521-9. PMID 22996645 DOI: 10.1242/Dmm.009985 |
0.379 |
|
| 2012 |
Brady RM, Hatzis E, Connor T, Street IP, Baell JB, Lessene G. Synthesis of conformationally constrained benzoylureas as BH3-mimetics. Organic & Biomolecular Chemistry. 10: 5230-7. PMID 22648632 DOI: 10.1039/C2Ob25618E |
0.319 |
|
| 2012 |
Street I, Monahan B, Falk H, Allan E, Bergman Y, Stupple P, Holmes I, Gregg A, Charman S, Lackovic K, Peat T, Walker S, Lowes K, Kersten W, Alcindor J, et al. Selective Inhibitors of Arginine Methyl Transferase 5 (PRMT5) As a Novel Treatment for β-Thalassemia and Sickle Cell Disease. Blood. 120: 2129-2129. DOI: 10.1182/Blood.V120.21.2129.2129 |
0.4 |
|
| 2012 |
Street I, Sylva Md, Lackovic K, Ganame D, Holloway G, Anderson R, McArthur G, Natoli A, Doherty J, Falk H, Kersten W, Lessene R, Leuchowius K, Novello P, Yang H, et al. Abstract LB-308: Combination of CTx-0294945 a highly selective inhibitor of focal adhesion kinase with bevacizumab in pre-clinical models of breast cancer Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-308 |
0.372 |
|
| 2012 |
Street I, Lackovic K, Haupt Y, Monahan B, Wolyniec K, Haupt S, Chan A, Falk H, Allan L, Pilling P. 1039 A High Throughput Screening Platform for the Identification of Small Molecule Inhibitors of the E3 Ligase E6AP European Journal of Cancer. 48: S250. DOI: 10.1016/S0959-8049(12)71650-7 |
0.321 |
|
| 2012 |
Street I, Holmes I, Devlin M, Bergman Y, Doherty J, Natoli A, Falk H, Nikac M, Choi N, Walker S. 846 Inhibition of Focal Adhesion Kinase in Combination With Bevacizumab Reduces the Rate of Tumor Revascularization and Increases Survival in a Pre-clinical Model of Basal Breast Cancer European Journal of Cancer. 48. DOI: 10.1016/S0959-8049(12)71479-X |
0.356 |
|
| 2011 |
Falk H, Connor T, Yang H, Loft KJ, Alcindor JL, Nikolakopoulos G, Surjadi RN, Bentley JD, Hattarki MK, Dolezal O, Murphy JM, Monahan BJ, Peat TS, Thomas T, Baell JB, ... ... Street IP, et al. An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets. Journal of Biomolecular Screening. 16: 1196-205. PMID 22086725 DOI: 10.1177/1087057111421631 |
0.427 |
|
| 2011 |
Sleebs BE, Nikolakopoulos G, Street IP, Falk H, Baell JB. Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5992-4. PMID 21852129 DOI: 10.1016/J.Bmcl.2011.07.050 |
0.36 |
|
| 2011 |
Patterson S, Alphey MS, Jones DC, Shanks EJ, Street IP, Frearson JA, Wyatt PG, Gilbert IH, Fairlamb AH. Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography. Journal of Medicinal Chemistry. 54: 6514-30. PMID 21851087 DOI: 10.1021/Jm200312V |
0.381 |
|
| 2011 |
Sleebs BE, Czabotar PE, Fairbrother WJ, Fairlie WD, Flygare JA, Huang DC, Kersten WJ, Koehler MF, Lessene G, Lowes K, Parisot JP, Smith BJ, Smith ML, Souers AJ, Street IP, et al. Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity. Journal of Medicinal Chemistry. 54: 1914-26. PMID 21366295 DOI: 10.1021/Jm101596E |
0.375 |
|
| 2011 |
Sleebs BE, Ganame D, Levit A, Street IP, Gregg A, Falk H, Baell JB. Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors Medchemcomm. 2: 982-986. DOI: 10.1039/C1Md00138H |
0.389 |
|
| 2011 |
Sleebs BE, Levit A, Street IP, Falk H, Hammonds T, Wong AC, Charles MD, Olson MF, Baell JB. Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors Medchemcomm. 2: 977-981. DOI: 10.1039/C1Md00137J |
0.36 |
|
| 2010 |
Holloway GA, Parisot JP, Novello PM, Watson KG, Armstrong T, Thompson RC, Street IP, Baell JB. Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi. Bioorganic & Medicinal Chemistry Letters. 20: 1816-8. PMID 20185305 DOI: 10.1016/J.Bmcl.2010.02.022 |
0.345 |
|
| 2010 |
Lackovic K, Parisot JP, Sleebs N, Baell JB, Debien L, Watson KG, Curtis JM, Handman E, Street IP, Kedzierski L. Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library. Antimicrobial Agents and Chemotherapy. 54: 1712-9. PMID 20160053 DOI: 10.1128/Aac.01634-09 |
0.388 |
|
| 2010 |
Sleebs BE, Street IP, Bu X, Baell JB. De novo synthesis of a potent LIMK1 inhibitor Synthesis. 1091-1096. DOI: 10.1055/S-0029-1219230 |
0.347 |
|
| 2009 |
Holloway GA, Charman WN, Fairlamb AH, Brun R, Kaiser M, Kostewicz E, Novello PM, Parisot JP, Richardson J, Street IP, Watson KG, Baell JB. Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity. Antimicrobial Agents and Chemotherapy. 53: 2824-33. PMID 19364854 DOI: 10.1128/Aac.01568-08 |
0.389 |
|
| 2007 |
Holloway GA, Baell JB, Fairlamb AH, Novello PM, Parisot JP, Richardson J, Watson KG, Street IP. Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening. Bioorganic & Medicinal Chemistry Letters. 17: 1422-7. PMID 17194585 DOI: 10.1016/J.Bmcl.2006.11.090 |
0.399 |
|
| 2007 |
Rye CS, Baell JB, Street I. Synthesis, reactivity and applications of 1-fluoroalkyl carboxylates: novel synthetic substrates for esterases and lipases Tetrahedron. 63: 3306-3311. DOI: 10.1016/J.Tet.2007.02.059 |
0.319 |
|
| 1997 |
Street IP, Withers SG. Probing the ionization state of substrate alpha-D-glucopyranosyl phosphate bound to glycogen phosphorylase b. The Biochemical Journal. 1017-23. PMID 8948464 DOI: 10.1042/Bj3081017 |
0.307 |
|
| 1996 |
Lai EC, Morris SA, Street IP, Withers SG. Substituted glycals as probes of glycosidase mechanisms. Bioorganic & Medicinal Chemistry. 4: 1929-37. PMID 9007277 DOI: 10.1016/S0968-0896(96)00175-7 |
0.316 |
|
| 1995 |
Abdullah K, Cromlish WA, Payette P, Laliberté F, Huang Z, Street I, Kennedy BP. Human cytosolic phospholipase A2 expressed in insect cells is extensively phosphorylated on Ser-505. Biochimica Et Biophysica Acta. 1244: 157-64. PMID 7766652 DOI: 10.1016/0304-4165(94)00218-M |
0.305 |
|
| 1993 |
Trimble LA, Street IP, Perrier H, Tremblay NM, Weech PK, Bernstein MA. NMR structural studies of the tight complex between a trifluoromethyl ketone inhibitor and the 85-kDa human phospholipase A2 Biochemistry. 32: 12560-12565. PMID 8251473 DOI: 10.1021/Bi00210A002 |
0.356 |
|
| 1993 |
Street IP, Lin HK, Laliberté F, Ghomashchi F, Wang Z, Perrier H, Tremblay NM, Huang Z, Weech PK, Gelb MH. Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. Biochemistry. 32: 5935-40. PMID 8018213 DOI: 10.1021/Bi00074A003 |
0.38 |
|
| 1992 |
Street IP, Kempton JB, Withers SG. Inactivation of a beta-glucosidase through the accumulation of a stable 2-deoxy-2-fluoro-alpha-D-glucopyranosyl-enzyme intermediate: a detailed investigation. Biochemistry. 31: 9970-8. PMID 1390781 DOI: 10.1021/Bi00156A016 |
0.307 |
|
| 1987 |
Withers SG, Street IP, Bird P, Dolphin DH. 2-Deoxy-2-fluoroglucosides: A novel class of mechanism-based glucosidase inhibitors Journal of the American Chemical Society. 109: 7530-7531. DOI: 10.1021/Ja00258A047 |
0.346 |
|
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