| Year |
Citation |
Score |
| 2019 |
Ahn S, Kim YS, Kim MS, Ann J, Ha H, Yoo YD, Kim YH, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Discovery of indane propanamides as potent and selective TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 126838. PMID 31864799 DOI: 10.1016/J.Bmcl.2019.126838 |
0.304 |
|
| 2019 |
Ann J, Kim HS, Thorat SA, Kim H, Ha H, Choi K, Kim YH, Kim M, Hwang SW, Pearce LV, Esch TE, Turcios NA, Blumberg PM, Lee J. Discovery of Non-pungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic. Journal of Medicinal Chemistry. PMID 31702924 DOI: 10.1021/Acs.Jmedchem.9B01046 |
0.304 |
|
| 2019 |
Lee H, Ahn S, Ann J, Ha H, Yoo YD, Kim YH, Hwang JY, Hur KH, Jang CG, Pearce LV, Esch TE, Lewin NE, Blumberg PM, Lee J. Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain. European Journal of Medicinal Chemistry. 182: 111634. PMID 31472474 DOI: 10.1016/J.Ejmech.2019.111634 |
0.315 |
|
| 2019 |
Pearce LV, Ann J, Blumberg PM, Lee J. Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level. Biomolecules & Therapeutics. PMID 31302951 DOI: 10.4062/Biomolther.2019.013 |
0.327 |
|
| 2019 |
Blanco FA, Czikora A, Kedei N, You Y, Mitchell GA, Pany S, Ghosh A, Blumberg PM, Das J. Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry. PMID 31243993 DOI: 10.1021/Acs.Biochem.9B00427 |
0.415 |
|
| 2019 |
Cooke M, Casado-Medrano V, Ann J, Lee J, Blumberg PM, Abba MC, Kazanietz MG. Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes. Scientific Reports. 9: 6041. PMID 30988374 DOI: 10.1038/S41598-019-42581-4 |
0.377 |
|
| 2018 |
Kim C, Ann J, Lee S, Kim E, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. 4-Aminophenyl acetamides and propanamides as potent transient receptor potential vanilloid 1 (TRPV1) ligands. Bioorganic & Medicinal Chemistry. PMID 30078610 DOI: 10.1016/J.Bmc.2018.07.040 |
0.379 |
|
| 2018 |
Kim C, Ann J, Lee S, Sun W, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Discovery of 2-(3,5-difluoro-4-methylsulfonaminophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 29884534 DOI: 10.1016/J.Bmcl.2018.05.043 |
0.335 |
|
| 2018 |
Ann J, Czikora A, Saini A, Zhou X, Mitchell GA, Lewin NE, Peach ML, Blumberg PM, Lee J. α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine Releasing Protein 3 (RasGRP3) Ligands. Journal of Medicinal Chemistry. PMID 29860841 DOI: 10.1021/Acs.Jmedchem.8B00661 |
0.452 |
|
| 2018 |
Cooke M, Zhou X, Casado-Medrano V, Lopez-Haber C, Baker MJ, Garg R, Ann J, Lee J, Blumberg PM, Kazanietz MG. Characterization of AJH-836, a DAG-lactone with selectivity for novel PKC isozymes. The Journal of Biological Chemistry. PMID 29636415 DOI: 10.1074/Jbc.Ra117.000235 |
0.487 |
|
| 2018 |
Zhao X, Kedei N, Michalowski AM, Lewin NE, Keck GE, Blumberg PM. Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency. Chembiochem : a European Journal of Chemical Biology. PMID 29517836 DOI: 10.1002/Cbic.201700677 |
0.431 |
|
| 2018 |
Cummins TJ, Kedei N, Czikora A, Lewin NE, Kirk S, Petersen ME, McGowan KM, Chen JQ, Luo X, Johnson RC, Ravichandran S, Blumberg PM, Keck GE. Synthesis and Biological Evaluation of Fluorescent Bryostatin Analogues. Chembiochem : a European Journal of Chemical Biology. PMID 29424951 DOI: 10.1002/Cbic.201700655 |
0.329 |
|
| 2018 |
Czikora A, Pany S, You Y, Saini AS, Lewin NE, Mitchell GA, Abramovitz A, Kedei N, Blumberg PM, Das J. Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta. Biochimica Et Biophysica Acta. PMID 29317197 DOI: 10.1016/J.Bbamem.2018.01.007 |
0.384 |
|
| 2017 |
Das J, Kedei N, Kelsey JS, You Y, Pany S, Mitchell GA, Lewin NE, Blumberg PM. Critical role of Trp-588 of presynaptic Munc13-1 for ligand binding and membrane translocation. Biochemistry. PMID 29244485 DOI: 10.1021/Acs.Biochem.7B00764 |
0.427 |
|
| 2017 |
Kelsey JS, Géczy T, Kaler CJ, Blumberg PM. The C1 domain of Vav3, a novel potential therapeutic target. Cellular Signalling. 40: 133-142. PMID 28927664 DOI: 10.1016/J.Cellsig.2017.09.008 |
0.447 |
|
| 2017 |
Czikora A, Kedei N, Kalish H, Blumberg PM. Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3. Biochimica Et Biophysica Acta. 1859: 2350-2360. PMID 28912101 DOI: 10.1016/J.Bbamem.2017.09.010 |
0.318 |
|
| 2017 |
Pearce LV, Ann J, Jung A, Thorat SA, Herold BKA, Habtemichael AD, Blumberg PM, Lee J. Novel Radiolabeled Vanilloid with Enhanced Specificity for Human Transient Receptor Potential Vanilloid 1 (TRPV1). Journal of Medicinal Chemistry. PMID 28892388 DOI: 10.1021/Acs.Jmedchem.7B00859 |
0.332 |
|
| 2017 |
Lee S, Kim C, Ann J, Thorat SA, Kim E, Park J, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 28838698 DOI: 10.1016/J.Bmcl.2017.08.020 |
0.396 |
|
| 2017 |
Ohashi N, Kobayashi R, Nomura W, Kobayakawa T, Czikora A, Herold B, Lewin N, Blumberg PM, Tamamura H. Synthesis and evaluation of dimeric derivatives of diacylglycerol-lactones as PKC ligands. Bioconjugate Chemistry. PMID 28671468 DOI: 10.1021/Acs.Bioconjchem.7B00299 |
0.452 |
|
| 2017 |
Elhalem E, Donadío LG, Zhou X, Lewin NE, Garcia LC, Lai CC, Kelley JA, Peach ML, Blumberg PM, Comin MJ. Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP. Bioorganic & Medicinal Chemistry. PMID 28392275 DOI: 10.1016/J.Bmc.2017.03.022 |
0.439 |
|
| 2017 |
Lee S, Kang DW, Ryu H, Kim C, Ann J, Lee H, Kim E, Hong S, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry. PMID 28314510 DOI: 10.1016/J.Bmc.2017.03.004 |
0.365 |
|
| 2017 |
Abramovitz A, Kedei N, Blumberg PM. Abstract 5344: Understanding the structural requirements of C1 domains for phorbol ester binding, analysis of the atypical C1 domain of STAC2 Cancer Research. 77: 5344-5344. DOI: 10.1158/1538-7445.Am2017-5344 |
0.366 |
|
| 2017 |
Czikora A, Pany S, You Y, Saini A, Kedei N, Lewin NE, Abramovitz A, Das J, Blumberg PM. Abstract 2373: Analysis of the distinct activities of the C1a and C1b domains of protein kinase C theta Cancer Research. 77: 2373-2373. DOI: 10.1158/1538-7445.Am2017-2373 |
0.381 |
|
| 2017 |
Kedei N, Das S, Andresson T, Blumberg PM. Abstract 215: Characterization by mass spectrometry of protein kinase C substrates differentially phosphorylated in LNCaP cells in response to phorbol ester and bryostatin 1 treatment Cancer Research. 77: 215-215. DOI: 10.1158/1538-7445.Am2017-215 |
0.391 |
|
| 2016 |
Petersen ME, Kedei N, Lewin NE, Blumberg PM, Keck GE. Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC. Tetrahedron Letters. 57: 4749-4753. PMID 27713589 DOI: 10.1016/J.Tetlet.2016.09.040 |
0.365 |
|
| 2016 |
Ketcham JM, Volchkov I, Chen TY, Blumberg PM, Kedei N, Lewin NE, Krische MJ. Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology. Journal of the American Chemical Society. PMID 27676096 DOI: 10.1021/Jacs.6B08695 |
0.441 |
|
| 2016 |
Baumann DO, McGowan KM, Kedei N, Peach ML, Blumberg PM, Keck GE. Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-ring. The Journal of Organic Chemistry. PMID 27494208 DOI: 10.1021/Acs.Joc.6B01516 |
0.437 |
|
| 2016 |
Ann J, Sun W, Zhou X, Jung A, Baek J, Lee S, Kim C, Yoon S, Hong S, Choi S, Turcios NA, Herold BK, Esch TE, Lewin NE, Abramovitz A, ... ... Blumberg PM, et al. Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template. Bioorganic & Medicinal Chemistry Letters. PMID 27317643 DOI: 10.1016/J.Bmcl.2016.06.010 |
0.336 |
|
| 2016 |
Zhang F, Hanson SM, Jara-Oseguera A, Krepkiy D, Bae C, Pearce LV, Blumberg PM, Newstead S, Swartz KJ. Engineering vanilloid-sensitivity into the rat TRPV2 channel. Elife. 5. PMID 27177419 DOI: 10.7554/Elife.16409 |
0.339 |
|
| 2016 |
Czikora A, Lundberg DJ, Abramovitz A, Lewin NE, Kedei N, Peach ML, Zhou X, Merritt RC, Craft EA, Braun DC, Blumberg PM. Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester with high affinity. The Journal of Biological Chemistry. PMID 27022025 DOI: 10.1074/Jbc.M116.725333 |
0.43 |
|
| 2016 |
Feng Z, Pearce LV, Zhang Y, Xing C, Herold BK, Ma S, Hu Z, Turcios NA, Yang P, Tong Q, McCall AK, Blumberg PM, Xie XQ. Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation. The Aaps Journal. PMID 27000851 DOI: 10.1208/S12248-016-9888-Z |
0.37 |
|
| 2016 |
Ann J, Ki Y, Yoon S, Kim MS, Lee JU, Kim C, Lee S, Jung A, Baek J, Hong S, Choi S, Pearce LV, Esch TE, Turcios NA, Lewin NE, ... ... Blumberg PM, et al. 2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry. PMID 26860926 DOI: 10.1016/J.Bmc.2016.01.051 |
0.379 |
|
| 2016 |
Kelsey JS, Cataisson C, Chen J, Herrmann MA, Petersen ME, Baumann DA, McGowan KM, Yuspa SH, Keck GE, Blumberg PM. Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin. Molecular Carcinogenesis. PMID 26859836 DOI: 10.1002/Mc.22460 |
0.35 |
|
| 2016 |
Kedei N, Paine EL, Jenkins LMM, Blumberg PM. Abstract 4423: Methylation and acetylation are novel post-translational modifications identified for the pre-apoptotic protein kinase C (PKC) delta Cancer Research. 76: 4423-4423. DOI: 10.1158/1538-7445.Am2016-4423 |
0.364 |
|
| 2016 |
Chen J, Kedei N, Goldstein DJ, Malik MQ, Blumberg PM. Abstract 3889: An aptamer-based multiplexed proteomic technology reveals differential PKC ligand responses Cancer Research. 76: 3889-3889. DOI: 10.1158/1538-7445.Am2016-3889 |
0.408 |
|
| 2016 |
Czikora A, Kedei N, Blumberg PM. Abstract 1126: Importance of the REM (Ras exchange) motif for membrane interactions by RasGRP3 Cancer Research. 76: 1126-1126. DOI: 10.1158/1538-7445.Am2016-1126 |
0.34 |
|
| 2015 |
Ann J, Jung A, Kim MY, Kim HM, Ryu H, Kim S, Kang DW, Hong S, Cui M, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, et al. Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry. PMID 26474664 DOI: 10.1016/J.Bmc.2015.10.001 |
0.404 |
|
| 2015 |
Tran PT, Kim HS, Ann J, Kim SE, Kim C, Hong M, Hoang VH, Ngo VT, Hong S, Cui M, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, et al. α-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 25: 2326-30. PMID 25937016 DOI: 10.1016/J.Bmcl.2015.04.024 |
0.315 |
|
| 2015 |
Kedei N, Kraft MB, Keck GE, Herald CL, Melody N, Pettit GR, Blumberg PM. Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships. Journal of Natural Products. 78: 896-900. PMID 25808573 DOI: 10.1021/Acs.Jnatprod.5B00094 |
0.315 |
|
| 2015 |
Lee HK, Finniss S, Cazacu S, Xiang C, Poisson LM, Blumberg PM, Brodie C. RasGRP3 regulates the migration of glioma cells via interaction with Arp3. Oncotarget. 6: 1850-64. PMID 25682201 DOI: 10.18632/Oncotarget.2575 |
0.578 |
|
| 2015 |
Ryu H, Seo S, Lee JY, Ha TH, Lee S, Jung A, Ann J, Kim SE, Yoon S, Hong M, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Schiene K, Stockhausen H, et al. Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. European Journal of Medicinal Chemistry. 93: 101-8. PMID 25659771 DOI: 10.1016/J.Ejmech.2015.02.001 |
0.378 |
|
| 2015 |
Feng Z, Pearce LV, Xu X, Yang X, Yang P, Blumberg PM, Xie XQ. Structural insight into tetrameric hTRPV1 from homology modeling, molecular docking, molecular dynamics simulation, virtual screening, and bioassay validations. Journal of Chemical Information and Modeling. 55: 572-88. PMID 25642729 DOI: 10.1021/Ci5007189 |
0.339 |
|
| 2015 |
Sun W, Kim HS, Lee S, Jung A, Kim SE, Ann J, Yoon S, Choi S, Lee JH, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Schiene K, Stockhausen H, Christoph T, et al. 6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 25: 803-6. PMID 25597011 DOI: 10.1016/J.Bmcl.2014.12.086 |
0.319 |
|
| 2015 |
Ann J, Yoon S, Baek J, Kim da H, Lewin NE, Hill CS, Blumberg PM, Lee J. Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones). European Journal of Medicinal Chemistry. 90: 332-41. PMID 25437619 DOI: 10.1016/J.Ejmech.2014.11.025 |
0.421 |
|
| 2015 |
Czifra G, Szöll?si A, Nagy Z, Boros M, Juhász I, Kiss A, Erd?di F, Szabó T, Kovács I, Török M, Kovács L, Blumberg PM, Bíró T. Protein kinase Cδ promotes proliferation and induces malignant transformation in skeletal muscle. Journal of Cellular and Molecular Medicine. 19: 396-407. PMID 25283340 DOI: 10.1111/Jcmm.12452 |
0.314 |
|
| 2015 |
Czikora A, Lundberg DJ, Lewin NE, Kedei N, Blumberg PM. Abstract 3928: Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester Cancer Research. 75: 3928-3928. DOI: 10.1158/1538-7445.Am2015-3928 |
0.43 |
|
| 2014 |
Andrews IP, Ketcham JM, Blumberg PM, Kedei N, Lewin NE, Peach ML, Krische MJ. Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties. Journal of the American Chemical Society. 136: 13209-16. PMID 25207655 DOI: 10.1021/Ja507825S |
0.363 |
|
| 2014 |
Ryu H, Seo S, Kim MS, Kim MY, Kim HS, Ann J, Tran PT, Hoang VH, Byun J, Cui M, Son K, Sharma PK, Choi S, Blumberg PM, Frank-Foltyn R, et al. 2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 4044-7. PMID 25011915 DOI: 10.1016/J.Bmcl.2014.05.072 |
0.388 |
|
| 2014 |
Kedei N, Chen JQ, Herrmann MA, Telek A, Goldsmith PK, Petersen ME, Keck GE, Blumberg PM. Molecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligands. Journal of Medicinal Chemistry. 57: 5356-69. PMID 24906106 DOI: 10.1021/Jm500417B |
0.43 |
|
| 2014 |
Garcia LC, Donadío LG, Mann E, Kolusheva S, Kedei N, Lewin NE, Hill CS, Kelsey JS, Yang J, Esch TE, Santos M, Peach ML, Kelley JA, Blumberg PM, Jelinek R, et al. Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP. Bioorganic & Medicinal Chemistry. 22: 3123-40. PMID 24794745 DOI: 10.1016/J.Bmc.2014.04.024 |
0.443 |
|
| 2014 |
Kim HS, Jin MK, Kang SU, Lim JO, Tran PT, Hoang VH, Ann J, Ha TH, Pearce LV, Pavlyukovets VA, Blumberg PM, Lee J. α-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 2685-8. PMID 24794110 DOI: 10.1016/J.Bmcl.2014.04.054 |
0.347 |
|
| 2014 |
Nagy Z, Kovács I, Török M, Tóth D, Vereb G, Buzás K, Juhász I, Blumberg PM, BÃró T, Czifra G. Function of RasGRP3 in the formation and progression of human breast cancer. Molecular Cancer. 13: 96. PMID 24779681 DOI: 10.1186/1476-4598-13-96 |
0.322 |
|
| 2014 |
Kelsey JS, Geczy T, Lewin NE, Kedei N, Hill CS, Selezneva JS, Valle CJ, Woo W, Gorshkova I, Blumberg PM. Charge density influences C1 domain ligand affinity and membrane interactions. Chembiochem : a European Journal of Chemical Biology. 15: 1131-44. PMID 24777910 DOI: 10.1002/Cbic.201400041 |
0.417 |
|
| 2014 |
Pu Y, Kang JH, Sigano DM, Peach ML, Lewin NE, Marquez VE, Blumberg PM. Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains. Journal of Medicinal Chemistry. 57: 3835-44. PMID 24684293 DOI: 10.1021/Jm500165N |
0.425 |
|
| 2014 |
Kim MS, Ki Y, Ahn SY, Yoon S, Kim SE, Park HG, Sun W, Son K, Cui M, Choi S, Pearce LV, Esch TE, Deandrea-Lazarus IA, Blumberg PM, Lee J. Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands. Bioorganic & Medicinal Chemistry Letters. 24: 382-5. PMID 24321344 DOI: 10.1016/J.Bmcl.2013.10.064 |
0.357 |
|
| 2014 |
Chen J, Kedei N, Herrmann MA, Blumberg PM. Abstract 5315: Quantitative proteomic assessment of differential ligand responses downstream of protein kinase C activation Cancer Research. 74: 5315-5315. DOI: 10.1158/1538-7445.Am2014-5315 |
0.414 |
|
| 2014 |
Czikora A, Kedei N, Blumberg PM. Abstract 4450: Comparison of structural elements in RasGRP3 and RasGRP1 controlling membrane interaction Cancer Research. 74: 4450-4450. DOI: 10.1158/1538-7445.Am2014-4450 |
0.354 |
|
| 2014 |
Kedei N, Michalowski AM, Blumberg PM. Abstract 3195: Transient duration of action is the primary mechanism responsible for the unique biology of bryostatin 1 Cancer Research. 74: 3195-3195. DOI: 10.1158/1538-7445.Am2014-3195 |
0.36 |
|
| 2014 |
Kelsey J, Kedei N, Cataisson C, Petersen M, Yuspa S, Keck G, Blumberg P. Abstract 1642: Bryostatin 1 and the simplified analog Merle 23 have similar and opposing properties on mouse epidermal cells and mouse skin Cancer Research. 74: 1642-1642. DOI: 10.1158/1538-7445.Am2014-1642 |
0.382 |
|
| 2014 |
Zhang F, Krepkiy D, Bae C, Moiseenkova-Bell V, Hanson S, Gorshkova I, Pearce L, Blumberg PM, Kim JI, Swartz KJ. Lipid-Mediated Interaction of Double-Knot Toxin with TRPV1 Channels Biophysical Journal. 106: 336a. DOI: 10.1016/J.Bpj.2013.11.1923 |
0.314 |
|
| 2013 |
Ha TH, Ryu H, Kim SE, Kim HS, Ann J, Tran PT, Hoang VH, Son K, Cui M, Choi S, Blumberg PM, Frank R, Bahrenberg G, Schiene K, Christoph T, et al. TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides. Bioorganic & Medicinal Chemistry. 21: 6657-64. PMID 24035514 DOI: 10.1016/J.Bmc.2013.08.015 |
0.382 |
|
| 2013 |
Song X, Lopez-Campistrous A, Sun L, Dower NA, Kedei N, Yang J, Kelsey JS, Lewin NE, Esch TE, Blumberg PM, Stone JC. RasGRPs are targets of the anti-cancer agent ingenol-3-angelate. Plos One. 8: e72331. PMID 23991094 DOI: 10.1371/Journal.Pone.0072331 |
0.459 |
|
| 2013 |
Lim KS, Lee H, Kim SE, Ha TH, Ann J, Son K, Choi S, Sun W, Pearce LV, DeAndrea-Lazarus IA, Blumberg PM, Lee J. The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands. European Journal of Medicinal Chemistry. 68: 233-43. PMID 23981530 DOI: 10.1016/J.Ejmech.2013.07.042 |
0.317 |
|
| 2013 |
Chen JQ, Heldman MR, Herrmann MA, Kedei N, Woo W, Blumberg PM, Goldsmith PK. Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system. Analytical Biochemistry. 442: 97-103. PMID 23896461 DOI: 10.1016/J.Ab.2013.07.022 |
0.361 |
|
| 2013 |
Thorat SA, Kang DW, Ryu H, Kim MS, Kim HS, Ann J, Ha T, Kim SE, Son K, Choi S, Blumberg PM, Frank R, Bahrenberg G, Schiene K, Christoph T, et al. 2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region. European Journal of Medicinal Chemistry. 64: 589-602. PMID 23685943 DOI: 10.1016/J.Ejmech.2013.04.003 |
0.389 |
|
| 2013 |
van Veghel D, Cleynhens J, Pearce LV, DeAndrea-Lazarus IA, Blumberg PM, Van Laere K, Verbruggen A, Bormans G. New transient receptor potential vanilloid subfamily member 1 positron emission tomography radioligands: synthesis, radiolabeling, and preclinical evaluation. Acs Chemical Neuroscience. 4: 624-34. PMID 23421633 DOI: 10.1021/Cn300233V |
0.35 |
|
| 2013 |
Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, et al. Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1. Acs Chemical Biology. 8: 767-77. PMID 23369356 DOI: 10.1021/Cb300671S |
0.582 |
|
| 2013 |
Rahman GM, Shanker S, Lewin NE, Kedei N, Hill CS, Prasad BV, Blumberg PM, Das J. Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ). The Biochemical Journal. 451: 33-44. PMID 23289588 DOI: 10.1042/Bj20121307 |
0.44 |
|
| 2013 |
Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL. A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. Journal of Immunology (Baltimore, Md. : 1950). 190: 147-58. PMID 23209318 DOI: 10.4049/Jimmunol.1201458 |
0.375 |
|
| 2013 |
Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM. Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochemical Pharmacology. 85: 313-24. PMID 23146662 DOI: 10.1016/J.Bcp.2012.10.028 |
0.58 |
|
| 2013 |
van Veghel D, Cleynhens J, Pearce LV, Blumberg PM, Van Laere K, Verbruggen A, Bormans G. Synthesis and biological evaluation of [¹¹C]SB366791: a new PET-radioligand for in vivo imaging of the TRPV1 receptor. Nuclear Medicine and Biology. 40: 141-7. PMID 23141549 DOI: 10.1016/J.Nucmedbio.2012.08.011 |
0.322 |
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| 2013 |
Nagy Z, Orosz E, Kovács I, Török M, Tóth D, Bíró T, Blumberg PM, Czifra G. Abstract 4399: Investigation of RasGRP3 expression and function in human breast cancers and breast-derived ductal adenocarcinoma cell lines. Cancer Research. 73: 4399-4399. DOI: 10.1158/1538-7445.Am2013-4399 |
0.336 |
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| 2013 |
Kelsey J, Kedei N, Cataisson C, Petersen M, Yuspa S, Keck G, Blumberg P. Abstract 2454: Comparison of the activity of the bryostatin derivative Merle 23 with that of bryostatin 1 and phorbol ester in mouse epidermal cells. Cancer Research. 73: 2454-2454. DOI: 10.1158/1538-7445.Am2013-2454 |
0.387 |
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| 2013 |
Kedei N, Michalowski AM, Petersen ME, Keck GE, Blumberg PM. Abstract 2101: Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogue in LNCaP and U937 cells provides insight into their differential mechanism. Cancer Research. 73: 2101-2101. DOI: 10.1158/1538-7445.Am2013-2101 |
0.351 |
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| 2012 |
Heldman M, Herrmann M, Kedei N, Blumberg P, Goldsmith P. A fully automated capillary western system for absolute quantitation of endogenous PKC proteins: An approach to correlate protein quantity with function. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 31. PMID 28142421 DOI: 10.1200/Jco.2012.30.30_Suppl.31 |
0.39 |
|
| 2012 |
Kim MS, Ryu H, Kang DW, Cho SH, Seo S, Park YS, Kim MY, Kwak EJ, Kim YS, Bhondwe RS, Kim HS, Park SG, Son K, Choi S, DeAndrea-Lazarus IA, ... ... Blumberg PM, et al. 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region. Journal of Medicinal Chemistry. 55: 8392-408. PMID 22957803 DOI: 10.1021/Jm300780P |
0.403 |
|
| 2012 |
Cho Y, Kim MS, Kim HS, Ann J, Lee J, Pearce LV, Pavlyukovets VA, Morgan MA, Blumberg PM, Lee J. The SAR analysis of TRPV1 agonists with the α-methylated B-region. Bioorganic & Medicinal Chemistry Letters. 22: 5227-31. PMID 22796184 DOI: 10.1016/J.Bmcl.2012.06.059 |
0.315 |
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| 2012 |
Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Blumberg PM. Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity. Bioorganic & Medicinal Chemistry Letters. 22: 4084-8. PMID 22579485 DOI: 10.1016/J.Bmcl.2012.04.073 |
0.574 |
|
| 2012 |
Bhondwe RS, Kang DW, Kim MS, Kim HS, Park SG, Son K, Choi S, Kuhs KA, Pavlyukovets VA, Pearce LV, Blumberg PM, Lee J. Structure-activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism. Bioorganic & Medicinal Chemistry Letters. 22: 3656-60. PMID 22546668 DOI: 10.1016/J.Bmcl.2012.04.034 |
0.379 |
|
| 2012 |
Geczy T, Peach ML, El Kazzouli S, Sigano DM, Kang JH, Valle CJ, Selezneva J, Woo W, Kedei N, Lewin NE, Garfield SH, Lim L, Mannan P, Marquez VE, Blumberg PM. Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester. The Journal of Biological Chemistry. 287: 13137-58. PMID 22351766 DOI: 10.1074/Jbc.M111.320010 |
0.416 |
|
| 2012 |
Sun W, Liu K, Ryu H, Kang DW, Kim YS, Kim MS, Cho Y, Bhondwe RS, Thorat SA, Kim HS, Pearce LV, Pavlyukovets VA, Tran R, Morgan MA, Lazar J, ... ... Blumberg PM, et al. 2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the B and C-regions. Bioorganic & Medicinal Chemistry. 20: 1310-8. PMID 22227463 DOI: 10.1016/J.Bmc.2011.12.014 |
0.38 |
|
| 2012 |
Kim YS, Kil MJ, Kang SU, Ryu H, Kim MS, Cho Y, Bhondwe RS, Thorat SA, Sun W, Liu K, Lee JH, Choi S, Pearce LV, Pavlyukovets VA, Morgan MA, ... ... Blumberg PM, et al. N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region. Bioorganic & Medicinal Chemistry. 20: 215-24. PMID 22169633 DOI: 10.1016/J.Bmc.2011.11.008 |
0.366 |
|
| 2012 |
Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM. Abstract 3815: Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogues in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action Cancer Research. 72: 3815-3815. DOI: 10.1158/1538-7445.Am2012-3815 |
0.585 |
|
| 2011 |
Gal N, Kolusheva S, Kedei N, Telek A, Naeem TA, Lewin NE, Lim L, Mannan P, Garfield SH, El Kazzouli S, Sigano DM, Marquez VE, Blumberg PM, Jelinek R. N-methyl-substituted fluorescent DAG-indololactone isomers exhibit dramatic differences in membrane interactions and biological activity. Chembiochem : a European Journal of Chemical Biology. 12: 2331-40. PMID 23106081 DOI: 10.1002/Cbic.201100246 |
0.395 |
|
| 2011 |
Nomura W, Narumi T, Ohashi N, Serizawa Y, Lewin NE, Blumberg PM, Furuta T, Tamamura H. Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C. Chembiochem : a European Journal of Chemical Biology. 12: 535-9. PMID 22238145 DOI: 10.1002/Cbic.201000670 |
0.414 |
|
| 2011 |
Yang D, Tao J, Li L, Kedei N, Tóth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM. RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma. Oncogene. 30: 4590-600. PMID 21602881 DOI: 10.1038/Onc.2011.166 |
0.338 |
|
| 2011 |
Kedei N, Lubart E, Lewin NE, Telek A, Lim L, Mannan P, Garfield SH, Kraft MB, Keck GE, Kolusheva S, Jelinek R, Blumberg PM. Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells. Chembiochem : a European Journal of Chemical Biology. 12: 1242-51. PMID 21542090 DOI: 10.1002/Cbic.201100064 |
0.395 |
|
| 2011 |
Kedei N, Telek A, Czap A, Lubart ES, Czifra G, Yang D, Chen J, Morrison T, Goldsmith PK, Lim L, Mannan P, Garfield SH, Kraft MB, Li W, Keck GE, ... Blumberg PM, et al. The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line. Biochemical Pharmacology. 81: 1296-308. PMID 21458422 DOI: 10.1016/J.Bcp.2011.03.018 |
0.381 |
|
| 2011 |
Lee JH, Lee Y, Ryu H, Kang DW, Lee J, Lazar J, Pearce LV, Pavlyukovets VA, Blumberg PM, Choi S. Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies. Journal of Computer-Aided Molecular Design. 25: 317-27. PMID 21448716 DOI: 10.1007/S10822-011-9421-5 |
0.346 |
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| 2011 |
Ohashi N, Nomura W, Narumi T, Lewin NE, Itotani K, Blumberg PM, Tamamura H. Fluorescent-responsive synthetic C1b domains of protein kinase Cδ as reporters of specific high-affinity ligand binding. Bioconjugate Chemistry. 22: 82-7. PMID 21175182 DOI: 10.1021/Bc100414A |
0.397 |
|
| 2011 |
Lim KS, Kang DW, Kim YS, Kim MS, Park SG, Choi S, Pearce LV, Blumberg PM, Lee J. Receptor activity and conformational analysis of 5'-halogenated resiniferatoxin analogs as TRPV1 ligands. Bioorganic & Medicinal Chemistry Letters. 21: 299-302. PMID 21111618 DOI: 10.1016/J.Bmcl.2010.11.012 |
0.405 |
|
| 2011 |
Kedei N, Telek A, Lubart ES, Lewin NE, Yang D, Chen J, Herrmann MA, Goldsmith PK, Lim L, Mannam P, Garfield SH, Blumberg PM. Abstract 4058: Diverse patterns of biological response to phorbol esters and related protein kinaseC activators in LNCaP human prostate cancer cells Cancer Research. 71: 4058-4058. DOI: 10.1158/1538-7445.Am2011-4058 |
0.406 |
|
| 2011 |
Geczy T, Valle CJ, Selezneva JS, Kedei N, Lewin NE, Lim L, Mannam P, Garfield SH, Peach ML, Blumberg PM. Abstract 3854: Identification of crucial residues at the rim of the binding cleft of the C1 domain of Vav1 that determine its ligand sensitivity Cancer Research. 71: 3854-3854. DOI: 10.1158/1538-7445.Am2011-3854 |
0.43 |
|
| 2010 |
Kang DW, Kim YS, Lim KS, Kim MS, Pearce LV, Pavlyukovets VA, Tao AK, Lang-Kuhs KA, Blumberg PM, Lee J. Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin. Bioorganic & Medicinal Chemistry. 18: 8092-105. PMID 20937561 DOI: 10.1016/J.Bmc.2010.09.001 |
0.369 |
|
| 2010 |
Raifman O, Kolusheva S, El Kazzouli S, Sigano DM, Kedei N, Lewin NE, Lopez-Nicolas R, Ortiz-Espin A, Gomez-Fernandez JC, Blumberg PM, Marquez VE, Corbalan-Garcia S, Jelinek R. Membrane-surface anchoring of charged diacylglycerol-lactones correlates with biological activities. Chembiochem : a European Journal of Chemical Biology. 11: 2003-9. PMID 20715268 DOI: 10.1002/Cbic.201000343 |
0.384 |
|
| 2010 |
Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Peach ML, Blumberg PM. Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1. Angewandte Chemie (International Ed. in English). 49: 4580-4. PMID 20491108 DOI: 10.1002/Anie.201001200 |
0.514 |
|
| 2010 |
Kang JH, Kim Y, Won SH, Park SK, Lee CW, Kim HM, Lewin NE, Perry NA, Pearce LV, Lundberg DJ, Surawski RJ, Blumberg PM, Lee J. Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. Bioorganic & Medicinal Chemistry Letters. 20: 1008-12. PMID 20045644 DOI: 10.1016/J.Bmcl.2009.12.058 |
0.406 |
|
| 2010 |
Raifman O, Kolusheva S, Comin MJ, Kedei N, Lewin NE, Blumberg PM, Marquez VE, Jelinek R. Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities. The Febs Journal. 277: 233-43. PMID 19961537 DOI: 10.1111/J.1742-4658.2009.07477.X |
0.369 |
|
| 2010 |
Yang D, Juan T, Kedei N, Li L, Yuspa S, Blumberg P. Abstract 5029: RasGRP3- a new therapeutic target in human melanoma Cancer Research. 70: 5029-5029. DOI: 10.1158/1538-7445.Am10-5029 |
0.332 |
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| 2010 |
Kedei N, Telek A, Czifra G, Czap A, Chen J, Goldsmith PK, Keck GE, Blumberg PM. Abstract 4500: What distinguishes a PKC activator like phorbol ester from a PKC functional antagonist like bryostatin 1? Bryologues permit mechanistic insight Cancer Research. 70: 4500-4500. DOI: 10.1158/1538-7445.Am10-4500 |
0.391 |
|
| 2010 |
Lee J, Han K, Lee S, Kim S, Kang J, Lewin NE, Best LS, Blumberg PM, Marquez VE. ChemInform Abstract: 5-Acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a Novel Template for Protein Kinase C (PKC) Binding. Cheminform. 32: no-no. DOI: 10.1002/chin.200132112 |
0.333 |
|
| 2010 |
Ma D, Wang G, Wang S, Kozikowski AP, Lewin NE, Blumberg PM. ChemInform Abstract: Synthesis and Protein Kinase C Binding Activity of Benzolactam-V7. Cheminform. 30: no-no. DOI: 10.1002/CHIN.199937172 |
0.33 |
|
| 2009 |
Ohashi N, Nomura W, Kato M, Narumi T, Lewin NE, Blumberg PM, Tamamura H. Synthesis of protein kinase Cdelta C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding. Journal of Peptide Science : An Official Publication of the European Peptide Society. 15: 642-6. PMID 19672879 DOI: 10.1002/Psc.1161 |
0.399 |
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| 2009 |
Tóth A, Blumberg PM, Boczán J. Anandamide and the vanilloid receptor (TRPV1). Vitamins and Hormones. 81: 389-419. PMID 19647120 DOI: 10.1016/S0083-6729(09)81015-7 |
0.331 |
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| 2009 |
Sosa MS, Lewin NE, Choi SH, Blumberg PM, Kazanietz MG. Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains. Biochemistry. 48: 8171-8. PMID 19618918 DOI: 10.1021/Bi9010623 |
0.368 |
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| 2009 |
Keck GE, Li W, Kraft MB, Kedei N, Lewin NE, Blumberg PM. The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses. Organic Letters. 11: 2277-80. PMID 19419164 DOI: 10.1021/Ol900585T |
0.449 |
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| 2009 |
Kozikowski AP, Chen Y, Subhasish T, Lewin NE, Blumberg PM, Zhong Z, D'Annibale MA, Wang WL, Shen Y, Langley B. Searching for disease modifiers - PKC activation and HDAC inhibition - A dual drug approach to Alzheimer's disease that decreases Aβ production while blocking oxidative stress Chemmedchem. 4: 1095-1105. PMID 19396896 DOI: 10.1002/Cmdc.200900045 |
0.329 |
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| 2009 |
Comin MJ, Czifra G, Kedei N, Telek A, Lewin NE, Kolusheva S, Velasquez JF, Kobylarz R, Jelinek R, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths. Journal of Medicinal Chemistry. 52: 3274-83. PMID 19379015 DOI: 10.1021/Jm900186M |
0.389 |
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| 2009 |
Choi HK, Choi S, Lee Y, Kang DW, Ryu H, Maeng HJ, Chung SJ, Pavlyukovets VA, Pearce LV, Toth A, Tran R, Wang Y, Morgan MA, Blumberg PM, Lee J. Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists. Bioorganic & Medicinal Chemistry. 17: 690-8. PMID 19135377 DOI: 10.1016/J.Bmc.2008.11.085 |
0.38 |
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| 2009 |
Keck GE, Poudel YB, Welch DS, Kraft MB, Truong AP, Stephens JC, Kedei N, Lewin NE, Blumberg PM. Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters. Organic Letters. 11: 593-6. PMID 19113896 DOI: 10.1021/Ol8027253 |
0.357 |
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| 2009 |
Stang SL, Lopez-Campistrous A, Song X, Dower NA, Blumberg PM, Wender PA, Stone JC. A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells. Experimental Hematology. 37: 122-134. PMID 19100522 DOI: 10.1016/J.Exphem.2008.09.008 |
0.362 |
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| 2009 |
Pu Y, Garfield SH, Kedei N, Blumberg PM. Characterization of the differential roles of the twin C1a and C1b domains of protein kinase C-delta. The Journal of Biological Chemistry. 284: 1302-12. PMID 19001377 DOI: 10.1074/Jbc.M804796200 |
0.371 |
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| 2009 |
Szegedi A, Páyer E, Czifra G, Tóth BI, Schmidt E, Kovács L, Blumberg PM, Bíró T. Protein kinase C isoenzymes differentially regulate the differentiation-dependent expression of adhesion molecules in human epidermal keratinocytes. Experimental Dermatology. 18: 122-9. PMID 18637128 DOI: 10.1111/J.1600-0625.2008.00771.X |
0.339 |
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| 2009 |
Lim JO, Jin MK, Ryu H, Kang DW, Lee J, Pearce LV, Tran R, Toth A, Blumberg PM. Conformationally constrained analogues of N'-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists. European Journal of Medicinal Chemistry. 44: 322-31. PMID 18406014 DOI: 10.1016/J.Ejmech.2008.02.026 |
0.33 |
|
| 2008 |
El Kazzouli S, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins. Journal of Medicinal Chemistry. 51: 5371-86. PMID 18707088 DOI: 10.1021/Jm800380B |
0.418 |
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| 2008 |
Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, El Kazzouli S, Chung JU, Young HA, ... ... Blumberg PM, et al. Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. Journal of Medicinal Chemistry. 51: 5198-220. PMID 18698758 DOI: 10.1021/Jm8001907 |
0.403 |
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| 2008 |
Blumberg PM, Kedei N, Lewin NE, Yang D, Czifra G, Pu Y, Peach ML, Marquez VE. Wealth of opportunity - the C1 domain as a target for drug development. Current Drug Targets. 9: 641-52. PMID 18691011 DOI: 10.2174/138945008785132376 |
0.382 |
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| 2008 |
Keck GE, Kraft MB, Truong AP, Li W, Sanchez CC, Kedei N, Lewin NE, Blumberg PM. Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function. Journal of the American Chemical Society. 130: 6660-1. PMID 18452293 DOI: 10.1021/Ja8022169 |
0.368 |
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| 2008 |
Lomonaco SL, Kahana S, Blass M, Brody Y, Okhrimenko H, Xiang C, Finniss S, Blumberg PM, Lee HK, Brodie C. Phosphorylation of protein kinase Cδ on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: Role in the apoptotic effect of etoposide Journal of Biological Chemistry. 283: 17731-17739. PMID 18434324 DOI: 10.1074/Jbc.M801727200 |
0.604 |
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| 2008 |
Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM. Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta. The Journal of Biological Chemistry. 283: 10543-9. PMID 18263588 DOI: 10.1074/Jbc.M707463200 |
0.443 |
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| 2008 |
Pearce LV, Toth A, Ryu H, Kang DW, Choi HK, Jin MK, Lee J, Blumberg PM. Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 149-57. PMID 18259730 DOI: 10.1007/S00210-007-0258-3 |
0.401 |
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| 2008 |
Gönczi M, Telek A, Czifra G, Balogh A, Blumberg PM, Bíró T, Csernoch L. Altered calcium handling following the recombinant overexpression of protein kinase C isoforms in HaCaT cells. Experimental Dermatology. 17: 584-91. PMID 18177346 DOI: 10.1111/J.1600-0625.2007.00678.X |
0.348 |
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| 2008 |
Ryu H, Jin MK, Kim SY, Choi HK, Kang SU, Kang DW, Lee J, Pearce LV, Pavlyukovets VA, Morgan MA, Tran R, Toth A, Lundberg DJ, Blumberg PM. Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues. Journal of Medicinal Chemistry. 51: 57-67. PMID 18072720 DOI: 10.1021/Jm701049P |
0.358 |
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| 2008 |
Zhu H, Yang Y, Zhang H, Han Y, Li Y, Zhang Y, Yin D, He Q, Zhao Z, Blumberg PM, Han J, Wang Y. Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity. Pain. 137: 574-88. PMID 18063480 DOI: 10.1016/J.Pain.2007.10.025 |
0.354 |
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| 2007 |
Chung JU, Kim SY, Lim JO, Choi HK, Kang SU, Yoon HS, Ryu H, Kang DW, Lee J, Kang B, Choi S, Toth A, Pearce LV, Pavlyukovets VA, Lundberg DJ, ... Blumberg PM, et al. Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorganic & Medicinal Chemistry. 15: 6043-53. PMID 17629487 DOI: 10.1016/J.Bmc.2007.06.041 |
0.305 |
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| 2007 |
Choi Y, Pu Y, Peach ML, Kang JH, Lewin NE, Sigano DM, Garfield SH, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta. Journal of Medicinal Chemistry. 50: 3465-81. PMID 17591763 DOI: 10.1021/Jm0702579 |
0.408 |
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| 2007 |
Tang L, Chen Y, Chen Z, Blumberg PM, Kozikowski AP, Wang ZJ. Antinociceptive pharmacology of N-(4-chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor. The Journal of Pharmacology and Experimental Therapeutics. 321: 791-8. PMID 17312187 DOI: 10.1124/Jpet.106.117572 |
0.338 |
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| 2007 |
Malolanarasimhan K, Kedei N, Sigano DM, Kelley JA, Lai CC, Lewin NE, Surawski RJ, Pavlyukovets VA, Garfield SH, Wincovitch S, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups. Journal of Medicinal Chemistry. 50: 962-78. PMID 17284021 DOI: 10.1021/Jm061289J |
0.413 |
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| 2007 |
Kang DW, Ryu H, Lee J, Lang KA, Pavlyukovets VA, Pearce LV, Ikeda T, Lazar J, Blumberg PM. Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin. Bioorganic & Medicinal Chemistry Letters. 17: 214-9. PMID 17035013 DOI: 10.1016/J.Bmcl.2006.09.059 |
0.342 |
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| 2006 |
Pu Y, Peach ML, Garfield SH, Wincovitch S, Marquez VE, Blumberg PM. Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms. The Journal of Biological Chemistry. 281: 33773-88. PMID 16950780 DOI: 10.1074/Jbc.M606560200 |
0.431 |
|
| 2006 |
Mach UR, Lewin NE, Blumberg PM, Kozikowski AP. Synthesis and pharmacological evaluation of 8- and 9-substituted benzolactam-V8 derivatives as potent ligands for protein kinase C, a therapeutic target for Alzheimer's disease Chemmedchem. 1: 307-314. PMID 16892365 DOI: 10.1002/Cmdc.200500068 |
0.409 |
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| 2006 |
Choi SH, Hyman T, Blumberg PM. Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase Cdelta. Cancer Research. 66: 7261-9. PMID 16849575 DOI: 10.1158/0008-5472.Can-05-4177 |
0.383 |
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| 2006 |
Kang JH, Benzaria S, Sigano DM, Lewin NE, Pu Y, Peach ML, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions. Journal of Medicinal Chemistry. 49: 3185-203. PMID 16722637 DOI: 10.1021/Jm060011O |
0.436 |
|
| 2006 |
Lee J, Kang JH, Han KC, Kim Y, Kim SY, Youn HS, Mook-Jung I, Kim H, Lo Han JH, Ha HJ, Kim YH, Marquez VE, Lewin NE, Pearce LV, Lundberg DJ, ... Blumberg PM, et al. Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators. Journal of Medicinal Chemistry. 49: 2028-36. PMID 16539391 DOI: 10.1021/Jm0509391 |
0.411 |
|
| 2006 |
Lazar J, Braun DC, Tóth A, Wang Y, Pearce LV, Pavlyukovets VA, Blumberg PM, Garfield SH, Wincovitch S, Choi HK, Lee J. Kinetics of penetration influence the apparent potency of vanilloids on TRPV1. Molecular Pharmacology. 69: 1166-73. PMID 16418338 DOI: 10.1124/Mol.105.019158 |
0.355 |
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| 2006 |
Czifra G, Tóth IB, Marincsák R, Juhász I, Kovács I, Acs P, Kovács L, Blumberg PM, BÃró T. Insulin-like growth factor-I-coupled mitogenic signaling in primary cultured human skeletal muscle cells and in C2C12 myoblasts. A central role of protein kinase Cdelta. Cellular Signalling. 18: 1461-72. PMID 16403461 DOI: 10.1016/J.Cellsig.2005.11.007 |
0.362 |
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| 2006 |
Lee J, Lee JH, Kim SY, Perry NA, Lewin NE, Ayres JA, Blumberg PM. 2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands. Bioorganic & Medicinal Chemistry. 14: 2022-31. PMID 16297629 DOI: 10.1016/J.Bmc.2005.10.051 |
0.44 |
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| 2005 |
Lizanecz E, Bagi Z, Pásztor ET, Papp Z, Edes I, Kedei N, Blumberg PM, Tóth A. Phosphorylation-dependent desensitization by anandamide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1. Molecular Pharmacology. 69: 1015-23. PMID 16338989 DOI: 10.1124/Mol.105.015644 |
0.4 |
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| 2005 |
Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C. Journal of Medicinal Chemistry. 48: 5738-48. PMID 16134942 DOI: 10.1021/Jm050352M |
0.423 |
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| 2005 |
Pu Y, Perry NA, Yang D, Lewin NE, Kedei N, Braun DC, Choi SH, Blumberg PM, Garfield SH, Stone JC, Duan D, Marquez VE. A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha. The Journal of Biological Chemistry. 280: 27329-38. PMID 15923197 DOI: 10.1074/Jbc.M414132200 |
0.455 |
|
| 2005 |
Qiang YW, Walsh K, Yao L, Kedei N, Blumberg PM, Rubin JS, Shaughnessy J, Rudikoff S. Wnts induce migration and invasion of myeloma plasma cells. Blood. 106: 1786-93. PMID 15886323 DOI: 10.1182/Blood-2005-01-0049 |
0.313 |
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| 2005 |
Tóth A, Wang Y, Kedei N, Tran R, Pearce LV, Kang SU, Jin MK, Choi HK, Lee J, Blumberg PM. Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. Life Sciences. 76: 2921-32. PMID 15820503 DOI: 10.1016/J.Lfs.2004.10.056 |
0.341 |
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| 2005 |
Okhrimenko H, Lu W, Xiang C, Ju D, Blumberg PM, Gomel R, Kazimirsky G, Brodie C. Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. The Journal of Biological Chemistry. 280: 23643-52. PMID 15774464 DOI: 10.1074/Jbc.M501374200 |
0.603 |
|
| 2005 |
Braun DC, Garfield SH, Blumberg PM. Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cdelta in the intact cell. The Journal of Biological Chemistry. 280: 8164-71. PMID 15611119 DOI: 10.1074/Jbc.M413896200 |
0.44 |
|
| 2004 |
Wang Y, Kedei N, Wang M, Wang QJ, Huppler AR, Toth A, Tran R, Blumberg PM. Interaction between protein kinase Cmu and the vanilloid receptor type 1. The Journal of Biological Chemistry. 279: 53674-82. PMID 15471852 DOI: 10.1074/Jbc.M410331200 |
0.434 |
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| 2004 |
Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C). Journal of Medicinal Chemistry. 47: 4858-64. PMID 15369389 DOI: 10.1021/Jm049723+ |
0.445 |
|
| 2004 |
Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM. Evodiamine functions as an agonist for the vanilloid receptor TRPV1 Organic and Biomolecular Chemistry. 2: 2281-2286. PMID 15305207 DOI: 10.1039/B404506H |
0.356 |
|
| 2004 |
Kang JH, Kim SY, Lee J, Marquez VE, Lewin NE, Pearce LV, Blumberg PM. Macrocyclic diacylglycerol-bis-lactones as conformationally constrained analogues of diacylglycerol-lactones. Interactions with protein kinase C. Journal of Medicinal Chemistry. 47: 4000-7. PMID 15267238 DOI: 10.1021/Jm0497747 |
0.449 |
|
| 2004 |
Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM. PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters. Molecular Pharmacology. 66: 76-84. PMID 15213298 DOI: 10.1124/Mol.66.1.76 |
0.639 |
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| 2004 |
Lee J, Kim SY, Lee J, Kang M, Kil MJ, Choi HK, Jin MK, Wang Y, Toth A, Pearce LV, Lundberg DJ, Tran R, Blumberg PM. Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism. Bioorganic & Medicinal Chemistry. 12: 3411-20. PMID 15186827 DOI: 10.1016/J.Bmc.2004.04.040 |
0.411 |
|
| 2004 |
Duan D, Lewin NE, Sigano DM, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands. Journal of Medicinal Chemistry. 47: 3248-54. PMID 15163204 DOI: 10.1021/Jm030610K |
0.355 |
|
| 2004 |
Kedei N, Lundberg DJ, Toth A, Welburn P, Garfield SH, Blumberg PM. Characterization of the interaction of ingenol 3-angelate with protein kinase C. Cancer Research. 64: 3243-55. PMID 15126366 DOI: 10.1158/0008-5472.Can-03-3403 |
0.456 |
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| 2004 |
Lázár J, Szabó T, Marincsák R, Kovács L, Blumberg PM, Bíró T. Sensitization of recombinant vanilloid receptor-1 by various neurotrophic factors. Life Sciences. 75: 153-63. PMID 15120568 DOI: 10.1016/J.Lfs.2003.11.023 |
0.377 |
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| 2004 |
Papp H, Czifra G, Bodó E, Lázár J, Kovács I, Aleksza M, Juhász I, Acs P, Sipka S, Kovács L, Blumberg PM, BÃró T. Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes. Cellular and Molecular Life Sciences : Cmls. 61: 1095-105. PMID 15112056 DOI: 10.1007/S00018-004-4014-2 |
0.375 |
|
| 2004 |
Lee J, Kang SU, Choi HK, Lee J, Lim JO, Kil MJ, Jin MK, Kim KP, Sung JH, Chung SJ, Ha HJ, Kim YH, Pearce LV, Tran R, Lundberg DJ, ... ... Blumberg PM, et al. Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity. Bioorganic & Medicinal Chemistry Letters. 14: 2291-7. PMID 15081027 DOI: 10.1016/J.Bmcl.2004.02.002 |
0.339 |
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| 2004 |
Pettit GR, Hoffmann H, Herald DL, McNulty J, Murphy A, Higgs KC, Hamel E, Lewin NE, Pearce LV, Blumberg PM, Pettit RK, Knight JC. Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine. The Journal of Organic Chemistry. 69: 2251-6. PMID 15049616 DOI: 10.1021/Jo0300486 |
0.329 |
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| 2004 |
Pettit GR, Hoffmann H, Herald DL, Blumberg PM, Hamel E, Schmidt JM, Chang Y, Pettit RK, Lewin NE, Pearce LV. Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine. Journal of Medicinal Chemistry. 47: 1775-82. PMID 15027869 DOI: 10.1021/Jm030070R |
0.309 |
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| 2004 |
Gavva NR, Klionsky L, Qu Y, Shi L, Tamir R, Edenson S, Zhang TJ, Viswanadhan VN, Toth A, Pearce LV, Vanderah TW, Porreca F, Blumberg PM, Lile J, Sun Y, et al. Molecular determinants of vanilloid sensitivity in TRPV1. The Journal of Biological Chemistry. 279: 20283-95. PMID 14996838 DOI: 10.1074/Jbc.M312577200 |
0.392 |
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| 2004 |
Lee J, Kim SY, Kang JH, Acs G, Acs P, Blumberg PM, Marquez VE. Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands. European Journal of Medicinal Chemistry. 39: 69-77. PMID 14987835 DOI: 10.1016/J.Ejmech.2003.10.006 |
0.413 |
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| 2004 |
Lee J, Kim SY, Park S, Lim JO, Kim JM, Kang M, Lee J, Kang SU, Choi HK, Jin MK, Welter JD, Szabo T, Tran R, Pearce LV, Toth A, ... Blumberg PM, et al. Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding. Bioorganic & Medicinal Chemistry. 12: 1055-69. PMID 14980619 DOI: 10.1016/J.Bmc.2003.12.005 |
0.403 |
|
| 2004 |
Tóth A, Blumberg PM, Chen Z, Kozikowski AP. Design of a High-Affinity Competitive Antagonist of the Vanilloid Receptor Selective for the Calcium Entry-Linked Receptor Population Molecular Pharmacology. 65: 282-291. PMID 14742669 DOI: 10.1124/Mol.65.2.282 |
0.327 |
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| 2004 |
Tamamura H, Sigano DM, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones. Journal of Medicinal Chemistry. 47: 644-55. PMID 14736244 DOI: 10.1021/Jm030454H |
0.436 |
|
| 2004 |
Lee J, Kang SU, Lim JO, Choi HK, Jin MK, Toth A, Pearce LV, Tran R, Wang Y, Szabo T, Blumberg PM. N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure-activity relationships for the "C-Region". Bioorganic & Medicinal Chemistry. 12: 371-85. PMID 14723956 DOI: 10.1016/J.Bmc.2003.10.047 |
0.402 |
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| 2004 |
Lewin NE, Blumberg PM. [3H]Phorbol 12,13-dibutyrate binding assay for protein kinase C and related proteins. Methods in Molecular Biology (Clifton, N.J.). 233: 129-56. PMID 12840504 DOI: 10.1385/1-59259-397-6:129 |
0.413 |
|
| 2004 |
Marquez VE, Blumberg PM. Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C). Accounts of Chemical Research. 36: 434-43. PMID 12809530 DOI: 10.1021/Ar020124B |
0.461 |
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| 2003 |
Wang QJ, Fang TW, Yang D, Lewin NE, Van Lint J, Marquez VE, Blumberg PM. Ligand structure-activity requirements and phospholipid dependence for the binding of phorbol esters to protein kinase D. Molecular Pharmacology. 64: 1342-8. PMID 14645664 DOI: 10.1124/Mol.64.6.1342 |
0.456 |
|
| 2003 |
Hamer DH, Bocklandt S, McHugh L, Chun TW, Blumberg PM, Sigano DM, Marquez VE. Rational design of drugs that induce human immunodeficiency virus replication. Journal of Virology. 77: 10227-36. PMID 12970407 DOI: 10.1128/Jvi.77.19.10227-10236.2003 |
0.301 |
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| 2003 |
Sridhar J, Wei ZL, Nowak I, Lewin NE, Ayres JA, Pearce LV, Blumberg PM, Kozikowski AP. New bivalent PKC ligands linked by a carbon spacer: Enhancement in binding affinity Journal of Medicinal Chemistry. 46: 4196-4204. PMID 12954072 DOI: 10.1021/Jm0302041 |
0.43 |
|
| 2003 |
Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, Lee J, Kang SU, Lim JO, Lee J. High-affinity partial agonists of the vanilloid receptor. Molecular Pharmacology. 64: 325-33. PMID 12869637 DOI: 10.1124/Mol.64.2.325 |
0.399 |
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| 2003 |
Lee J, Lee J, Kang M, Shin M, Kim JM, Kang SU, Lim JO, Choi HK, Suh YG, Park HG, Oh U, Kim HD, Park YH, Ha HJ, Kim YH, ... ... Blumberg PM, et al. N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor. Journal of Medicinal Chemistry. 46: 3116-26. PMID 12825950 DOI: 10.1021/Jm030089U |
0.384 |
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| 2003 |
Choi Y, Kang JH, Lewin NE, Blumberg PM, Lee J, Marquez VE. Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain. Journal of Medicinal Chemistry. 46: 2790-3. PMID 12801241 DOI: 10.1021/Jm030082C |
0.398 |
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| 2003 |
Tóth A, Kedei N, Wang Y, Blumberg PM. Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. Life Sciences. 73: 487-98. PMID 12759142 DOI: 10.1016/S0024-3205(03)00310-2 |
0.371 |
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| 2003 |
Kang JH, Chung HE, Kim SY, Kim Y, Lee J, Lewin NE, Pearce LV, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones Bioorganic and Medicinal Chemistry. 11: 2529-2539. PMID 12757721 DOI: 10.1016/S0968-0896(03)00156-1 |
0.439 |
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| 2003 |
Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C). Journal of Medicinal Chemistry. 46: 1571-9. PMID 12699375 DOI: 10.1021/Jm020476O |
0.388 |
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| 2003 |
Kozikowski AP, Nowak I, Petukhov PA, Etcheberrigaray R, Mohamed A, Tan M, Lewin N, Hennings H, Pearce LL, Blumberg PM. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα Journal of Medicinal Chemistry. 46: 364-373. PMID 12540236 DOI: 10.1021/Jm020350R |
0.406 |
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| 2003 |
Brodie C, Blumberg PM. Regulation of cell apoptosis by protein kinase c delta. Apoptosis : An International Journal On Programmed Cell Death. 8: 19-27. PMID 12510148 DOI: 10.1023/A:1021640817208 |
0.621 |
|
| 2002 |
Pettit GR, Ducki S, Tan R, Gardella RS, McMahon JB, Boyd MR, Pettit GR, Blumberg PM, Lewin NE, Doubek DL, Tackett LP, Williams MD. Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. Journal of Natural Products. 65: 1262-5. PMID 12350143 DOI: 10.1021/Np020115B |
0.34 |
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| 2002 |
Wang Y, Szabo T, Welter JD, Toth A, Tran R, Lee J, Kang SU, Suh YG, Blumberg PM, Lee J. High affinity antagonists of the vanilloid receptor. Molecular Pharmacology. 62: 947-56. PMID 12237342 DOI: 10.1124/Mol.62.4.947 |
0.332 |
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| 2002 |
Di Marzo V, Blumberg PM, Szallasi A. Endovanilloid signaling in pain. Current Opinion in Neurobiology. 12: 372-9. PMID 12139983 DOI: 10.1016/S0959-4388(02)00340-9 |
0.302 |
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| 2002 |
Tóth A, Kedei N, Szabó T, Wang Y, Blumberg PM. Thapsigargin binds to and inhibits the cloned vanilloid receptor-1. Biochemical and Biophysical Research Communications. 293: 777-82. PMID 12054538 DOI: 10.1016/S0006-291X(02)00293-0 |
0.335 |
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| 2002 |
Zrachia A, Dobroslav M, Blass M, Kazimirsky G, Kronfeld I, Blumberg PM, Kobiler D, Lustig S, Brodie C. Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis. The Journal of Biological Chemistry. 277: 23693-701. PMID 11927579 DOI: 10.1074/jbc.M111658200 |
0.568 |
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| 2002 |
Lee J, Lee J, Kang MS, Kim KP, Chung SJ, Blumberg PM, Yi JB, Park YH. Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics. Bioorganic & Medicinal Chemistry. 10: 1171-9. PMID 11836128 DOI: 10.1016/S0968-0896(01)00387-X |
0.32 |
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| 2002 |
Szabo T, Biro T, Gonzalez AF, Palkovits M, Blumberg PM. Pharmacological characterization of vanilloid receptor located in the brain. Brain Research. Molecular Brain Research. 98: 51-7. PMID 11834295 DOI: 10.1016/S0169-328X(01)00313-8 |
0.347 |
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| 2002 |
Rong SB, Enyedy IJ, Qiao L, Zhao L, Ma D, Pearce LL, Lorenzo PS, Stone JC, Blumberg PM, Wang S, Kozikowski AP. Structural basis of RasGRP binding to high-affinity PKC ligands. Journal of Medicinal Chemistry. 45: 853-60. PMID 11831896 DOI: 10.1021/Jm010422Z |
0.437 |
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| 2002 |
Blass M, Kronfeld I, Kazimirsky G, Blumberg PM, Brodie C. Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. Molecular and Cellular Biology. 22: 182-95. PMID 11739733 DOI: 10.1128/Mcb.22.1.182-195.2002 |
0.624 |
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| 2002 |
Lee J, Han KC, Kang JH, Pearce LL, Lewin NE, Yan S, Benzaria S, Nicklaus MC, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity. Journal of Medicinal Chemistry. 44: 4309-12. PMID 11728178 DOI: 10.1021/Jm0103965 |
0.448 |
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| 2002 |
Garcia-Bermejo ML, Leskow FC, Fujii T, Wang Q, Blumberg PM, Ohba M, Kuroki T, Han KC, Lee J, Marquez VE, Kazanietz MG. Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. The Journal of Biological Chemistry. 277: 645-55. PMID 11584014 DOI: 10.1074/Jbc.M107639200 |
0.309 |
|
| 2002 |
Nacro K, Lee J, Barchi JJ, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). Part 19: Asymmetric syntheses of (3R)- and (3S)-3-hydroxy-4,4-disubstituted heptono-1,4-lactones as protein kinase C (PK-C) ligands with increased hydrophilicity Tetrahedron. 58: 5335-5345. DOI: 10.1016/S0040-4020(02)00477-5 |
0.419 |
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| 2001 |
Kuzhikandathil EV, Wang H, Szabo T, Morozova N, Blumberg PM, Oxford GS. Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 8697-706. PMID 11698581 DOI: 10.1523/Jneurosci.21-22-08697.2001 |
0.344 |
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| 2001 |
Shao L, Lewin NE, Lorenzo PS, Hu Z, Enyedy IJ, Garfield SH, Stone JC, Marner FJ, Blumberg PM, Wang S. Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily. Journal of Medicinal Chemistry. 44: 3872-80. PMID 11689073 DOI: 10.1021/Jm010258F |
0.479 |
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| 2001 |
Lee J, Lee J, Szabo T, Gonzalez AF, Welter JD, Blumberg PM. N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands. Bioorganic & Medicinal Chemistry. 9: 1713-20. PMID 11425572 DOI: 10.1016/S0968-0896(01)00068-2 |
0.346 |
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| 2001 |
Lee J, Han KC, Lee SY, Kim SY, Kang JH, Lewin NE, Best LS, Blumberg PM, Marquez VE. 5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding. Farmaco (Societa Chimica Italiana : 1989). 56: 203-10. PMID 11409328 DOI: 10.1016/S0014-827X(01)01077-1 |
0.429 |
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| 2001 |
Nacro K, Sigano DM, Yan S, Nicklaus MC, Pearce LL, Lewin NE, Garfield SH, Blumberg PM, Marquez VE. An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P). Journal of Medicinal Chemistry. 44: 1892-904. PMID 11384235 DOI: 10.1021/Jm010052E |
0.455 |
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| 2001 |
Kedei N, Szabo T, Lile JD, Treanor JJ, Olah Z, Iadarola MJ, Blumberg PM. Analysis of the native quaternary structure of vanilloid receptor 1. The Journal of Biological Chemistry. 276: 28613-9. PMID 11358970 DOI: 10.1074/Jbc.M103272200 |
0.305 |
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| 2001 |
Pak Y, Enyedy IJ, Varady J, Kung JW, Lorenzo PS, Blumberg PM, Wang S. Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis. Journal of Medicinal Chemistry. 44: 1690-701. PMID 11356104 DOI: 10.1021/Jm000488E |
0.381 |
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| 2001 |
Wang QJ, Fang TW, Nacro K, Marquez VE, Wang S, Blumberg PM. Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions. The Journal of Biological Chemistry. 276: 19580-7. PMID 11278612 DOI: 10.1074/Jbc.M010089200 |
0.313 |
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| 2001 |
Ma D, Zhang T, Wang G, Kozikowski AP, Lewin NE, Blumberg PM. Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C. Bioorganic & Medicinal Chemistry Letters. 11: 99-101. PMID 11206480 DOI: 10.1016/S0960-894X(00)00609-0 |
0.415 |
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| 2001 |
Lee J, Lee J, Kim J, Kim SY, Chun MW, Cho H, Hwang SW, Oh U, Park YH, Marquez VE, Beheshti M, Szabo T, Blumberg PM. N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics. Bioorganic & Medicinal Chemistry. 9: 19-32. PMID 11197340 DOI: 10.1016/S0968-0896(00)00216-9 |
0.376 |
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| 2001 |
Olah Z, Szabo T, Karai L, Hough C, Fields RD, Caudle RM, Blumberg PM, Iadarola MJ. Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1. The Journal of Biological Chemistry. 276: 11021-30. PMID 11124944 DOI: 10.1074/Jbc.M008392200 |
0.345 |
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| 2001 |
Ma D, Zhang T, Wang G, Kozikowski AP, Lewin NE, Blumberg PM. ChemInform Abstract: Synthesis of 7,8-Disubstituted Benzolactam-V8 and Its Binding to Protein Kinase C. Cheminform. 32: no-no. DOI: 10.1002/CHIN.200117166 |
0.312 |
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| 2000 |
Tamamura H, Bienfait B, Nacro K, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C. Journal of Medicinal Chemistry. 43: 3209-17. PMID 10966739 DOI: 10.1021/Jm990613Q |
0.412 |
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| 2000 |
Kronfeld I, Kazimirsky G, Lorenzo PS, Garfield SH, Blumberg PM, Brodie C. Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions. The Journal of Biological Chemistry. 275: 35491-8. PMID 10945993 DOI: 10.1074/Jbc.M005991200 |
0.617 |
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| 2000 |
Acs P, Beheshti M, Szállási Z, Li L, Yuspa SH, Blumberg PM. Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts. Carcinogenesis. 21: 887-91. PMID 10783308 DOI: 10.1093/Carcin/21.5.887 |
0.338 |
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| 2000 |
Wang QJ, Fang TW, Fenick D, Garfield S, Bienfait B, Marquez VE, Blumberg PM. The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein. The Journal of Biological Chemistry. 275: 12136-46. PMID 10766849 DOI: 10.1074/Jbc.275.16.12136 |
0.398 |
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| 2000 |
Nacro K, Bienfait B, Lewin NE, Blumberg PM, Marquez VE. Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones. Bioorganic & Medicinal Chemistry Letters. 10: 653-5. PMID 10762046 DOI: 10.1016/S0960-894X(00)00070-6 |
0.432 |
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| 2000 |
Nacro K, Bienfait B, Lee J, Han KC, Kang JH, Benzaria S, Lewin NE, Bhattacharyya DK, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C? Journal of Medicinal Chemistry. 43: 921-44. PMID 10715158 DOI: 10.1021/Jm9904607 |
0.479 |
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| 2000 |
Li L, Lorenzo PS, Bogi K, Blumberg PM, Yuspa SH. Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Molecular and Cellular Biology. 19: 8547-58. PMID 10567579 DOI: 10.1128/Mcb.19.12.8547 |
0.355 |
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| 2000 |
Ebinu JO, Stang SL, Teixeira C, Bottorff DA, Hooton J, Blumberg PM, Barry M, Bleakley RC, Ostergaard HL, Stone JC. RasGRP links T-cell receptor signaling to Ras Blood. 95: 3199-3203. DOI: 10.1182/Blood.V95.10.3199 |
0.351 |
|
| 2000 |
Nacro K, Bienfait B, Lewin NE, Blumberg PM, Marquez VE. Corrigendum to “Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). a direct measure of the effect of constraining the glycerol backbone in DAG lactones” Bioorganic & Medicinal Chemistry Letters. 10: 1401. DOI: 10.1016/S0960-894X(00)00225-0 |
0.407 |
|
| 2000 |
Tamamura H, Bienfait B, Nacro K, Lewin NE, Blumberg PM, Marquez VE. ChemInform Abstract: Conformationally Constrained Analogues of Diacylglycerol (DAG). Part 17. Contrast Between sn-1 and sn-2 DAG Lactones in Binding to Protein Kinase C. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200050218 |
0.335 |
|
| 1999 |
Wang QJ, Bhattacharyya D, Garfield S, Nacro K, Marquez VE, Blumberg PM. Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein. The Journal of Biological Chemistry. 274: 37233-9. PMID 10601287 DOI: 10.1074/Jbc.274.52.37233 |
0.405 |
|
| 1999 |
Lee J, Park SU, Kim JY, Kim JK, Lee J, Oh U, Marquez VE, Beheshti M, Wang QJ, Modarres S, Blumberg PM. 3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists. Bioorganic & Medicinal Chemistry Letters. 9: 2909-14. PMID 10571146 DOI: 10.1016/S0960-894X(99)00513-2 |
0.353 |
|
| 1999 |
Caloca MJ, Garcia-Bermejo ML, Blumberg PM, Lewin NE, Kremmer E, Mischak H, Wang S, Nacro K, Bienfait B, Marquez VE, Kazanietz MG. beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain. Proceedings of the National Academy of Sciences of the United States of America. 96: 11854-9. PMID 10518540 DOI: 10.1073/Pnas.96.21.11854 |
0.416 |
|
| 1999 |
Lee J, Kang JH, Lee SY, Han KC, Torres CM, Bhattacharyya DK, Blumberg PM, Marquez VE. Protein kinase C ligands based on tetrahydrofuran templates containing a new set of phorbol ester pharmacophores Journal of Medicinal Chemistry. 42: 4129-4139. PMID 10514283 DOI: 10.1021/Jm980713G |
0.433 |
|
| 1999 |
Wang S, Liu M, Lewin NE, Lorenzo PS, Bhattacharrya D, Qiao L, Kozikowski AP, Blumberg PM. Probing the binding of indolactam-V to protein kinase C through site-directed mutagenesis and computational docking simulations. Journal of Medicinal Chemistry. 42: 3436-46. PMID 10479277 DOI: 10.1021/Jm990129N |
0.413 |
|
| 1999 |
Szallasi A, Blumberg PM, Annicelli LL, Krause JE, Cortright DN. The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons. Molecular Pharmacology. 56: 581-7. PMID 10462546 DOI: 10.1124/Mol.56.3.581 |
0.384 |
|
| 1999 |
Marquez VE, Nacro K, Benzaria S, Lee J, Sharma R, Teng K, Milne GW, Bienfait B, Wang S, Lewin NE, Blumberg PM. The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands. Pharmacology & Therapeutics. 82: 251-61. PMID 10454202 DOI: 10.1016/S0163-7258(98)00048-5 |
0.456 |
|
| 1999 |
Ma D, Wang G, Wang S, Kozikowski AP, Lewin NE, Blumberg PM. Synthesis and protein kinase C binding activity of benzolactam-V7. Bioorganic & Medicinal Chemistry Letters. 9: 1371-4. PMID 10360738 DOI: 10.1016/S0960-894X(99)00207-3 |
0.43 |
|
| 1999 |
Lee J, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol having a perhydrofuro[3,4-c]furan-1,4-dione bis-gamma-butyrolactone skeleton. Archives of Pharmacal Research. 21: 164-7. PMID 9875425 DOI: 10.1007/Bf02974022 |
0.393 |
|
| 1999 |
Benzaria S, Bienfait B, Nacro K, Wang S, Lewin NE, Beheshti M, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C). Bioorganic & Medicinal Chemistry Letters. 8: 3403-8. PMID 9873742 DOI: 10.1016/S0960-894X(98)00614-3 |
0.435 |
|
| 1999 |
Marquez VE, Sharma R, Wang S, Lewin NE, Blumberg PM, Kim IS, Lee J. Conformationally constrained analogues of diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2 carbonyls in DAG mimetics by isopharmacophore replacement. Bioorganic & Medicinal Chemistry Letters. 8: 1757-62. PMID 9873429 DOI: 10.1016/S0960-894X(98)00307-2 |
0.367 |
|
| 1999 |
Bíró T, Brodie C, Modarres S, Lewin NE, Acs P, Blumberg PM. Specific vanilloid responses in C6 rat glioma cells. Brain Research. Molecular Brain Research. 56: 89-98. PMID 9602075 DOI: 10.1016/S0169-328X(98)00033-3 |
0.64 |
|
| 1999 |
Ma D, Tang W, Kozikowski AP, Lewin NE, Blumberg PM. General and Stereospecific Route to 9-Substituted, 8,9-Disubstituted, and 9,10-Disubstituted Analogues of Benzolactam-V8 The Journal of Organic Chemistry. 64: 6366-6373. DOI: 10.1021/Jo990605H |
0.352 |
|
| 1999 |
Winkler JD, Kim S, Harrison S, Lewin NE, Blumberg PM. Synthesis and biological evaluation of highly functionalized analogues of ingenol Journal of the American Chemical Society. 121: 296-300. DOI: 10.1021/Ja9741842 |
0.359 |
|
| 1998 |
Brodie C, Bogi K, Acs P, Lorenzo PS, Baskin L, Blumberg PM. Protein kinase C delta (PKCdelta) inhibits the expression of glutamine synthetase in glial cells via the PKCdelta regulatory domain and its tyrosine phosphorylation. The Journal of Biological Chemistry. 273: 30713-8. PMID 9804846 DOI: 10.1074/Jbc.273.46.30713 |
0.625 |
|
| 1998 |
Szallasi A, BÃró T, Modarres S, Garlaschelli L, Petersen M, Klusch A, Vidari G, Jonassohn M, De Rosa S, Sterner O, Blumberg PM, Krause JE. Dialdehyde sesquiterpenes and other terpenoids as vanilloids. European Journal of Pharmacology. 356: 81-9. PMID 9761427 DOI: 10.1016/S0014-2999(98)00514-7 |
0.366 |
|
| 1998 |
Song JS, Swann PG, Szallasi Z, Blank U, Blumberg PM, Rivera J. Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta. Oncogene. 16: 3357-68. PMID 9692543 DOI: 10.1038/Sj.Onc.1201886 |
0.411 |
|
| 1998 |
Brodie C, Blumberg PM, Jacobson KA. Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells. Febs Letters. 429: 139-42. PMID 9650577 DOI: 10.1016/S0014-5793(98)00556-0 |
0.579 |
|
| 1998 |
Brodie C, Kuperstein I, Acs P, Blumberg PM. Differential role of specific PKC isoforms in the proliferation of glial cells and the expression of the astrocytic markers GFAP and glutamine synthetase. Brain Research. Molecular Brain Research. 56: 108-17. PMID 9602083 DOI: 10.1016/S0169-328X(98)00035-7 |
0.599 |
|
| 1998 |
Biro T, Acs G, Acs P, Modarres S, Blumberg PM. Recent advances in understanding of vanilloid receptors: a therapeutic target for treatment of pain and inflammation in skin. The Journal of Investigative Dermatology. Symposium Proceedings. 2: 56-60. PMID 9487017 DOI: 10.1038/Jidsymp.1997.12 |
0.378 |
|
| 1998 |
Bı́ró T, Maurer M, Modarres S, Lewin NE, Brodie C, Ács G, Ács P, Paus R, Blumberg PM. Characterization of Functional Vanilloid Receptors Expressed by Mast Cells Blood. 91: 1332-1340. DOI: 10.1182/Blood.V91.4.1332 |
0.627 |
|
| 1997 |
Appel E, Kolman O, Kazimirsky G, Blumberg PM, Brodie C. Regulation of GDNF expression in cultured astrocytes by inflammatory stimuli. Neuroreport. 8: 3309-12. PMID 9351662 DOI: 10.1097/00001756-199710200-00023 |
0.547 |
|
| 1997 |
Rosson D, O'Brien TG, Kampherstein JA, Szallasi Z, Bogi K, Blumberg PM, Mullin JM. Protein kinase C-alpha activity modulates transepithelial permeability and cell junctions in the LLC-PK1 epithelial cell line. The Journal of Biological Chemistry. 272: 14950-3. PMID 9169467 DOI: 10.1074/Jbc.272.23.14950 |
0.346 |
|
| 1997 |
Kozikowski AP, Wang S, Ma D, Yao J, Ahmad S, Glazer RI, Bogi K, Acs P, Modarres S, Lewin NE, Blumberg PM. Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity. Journal of Medicinal Chemistry. 40: 1316-26. PMID 9135029 DOI: 10.1021/Jm960875H |
0.454 |
|
| 1997 |
Szallasi A, Blumberg PM. Vanilloid receptors: new insights enhance potential as a therapeutic target. Pain. 68: 195-208. PMID 9121806 DOI: 10.1016/S0304-3959(96)03202-2 |
0.349 |
|
| 1997 |
Hurley JH, Newton AC, Parker PJ, Blumberg PM, Nishizuka Y. Taxonomy and function of C1 protein kinase C homology domains. Protein Science : a Publication of the Protein Society. 6: 477-80. PMID 9041654 DOI: 10.1002/Pro.5560060228 |
0.392 |
|
| 1997 |
Lee J, Lewin NE, Acs P, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 13. Protein kinase C ligands based on templates derived from 2,3-dideoxy-L-erythro(threo)-hexono-1,4-lactone and 2-deoxyapiolactone. Journal of Medicinal Chemistry. 39: 4912-9. PMID 8960550 DOI: 10.1021/Jm960525V |
0.398 |
|
| 1997 |
Acs G, Palkovits M, Blumberg PM. Specific binding of [3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations. Life Sciences. 59: 1899-908. PMID 8950287 DOI: 10.1016/S0024-3205(96)00537-1 |
0.346 |
|
| 1997 |
Lee J, Lewin NE, Blumberg PM, Marquez VE. Synthesis of bis-gamma-butyrolactones containing conformationally constrained (S)- and (R)-diacylglycerol structures. Bioorganic & Medicinal Chemistry. 4: 1299-305. PMID 8879551 DOI: 10.1016/0968-0896(96)00116-2 |
0.328 |
|
| 1997 |
Acs G, Biro T, Acs P, Modarres S, Blumberg PM. Differential Activation and Desensitization of Sensory Neurons by Resiniferatoxin The Journal of Neuroscience. 17: 5622-5628. DOI: 10.1523/Jneurosci.17-14-05622.1997 |
0.374 |
|
| 1997 |
Brodie C, Bogi K, Acs P, Lorenzo P, Baskin L, Blumberg P. The regulatory domain of PKCδ mediates its inhibitory effect on glutamine synthetase expresion in C6 glial cells: Role of tyrosine phosphorylation Neuroscience Letters. 237: S12. DOI: 10.1016/S0304-3940(97)90046-X |
0.624 |
|
| 1996 |
Szallasi A, Acs G, Cravotto G, Blumberg PM, Lundberg JM, Appendino G. A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor. European Journal of Pharmacology. 299: 221-8. PMID 8901026 DOI: 10.1016/0014-2999(95)00864-0 |
0.392 |
|
| 1996 |
Szallasi A, Nilsson S, Blumberg PM, Hökfelt T, Lundberg JM. Binding of neuroleptic drugs (trifluoperazine and rimcazole) to vanilloid receptors in porcine dorsal horn. European Journal of Pharmacology. 298: 321-7. PMID 8846833 DOI: 10.1016/0014-2999(95)00805-5 |
0.376 |
|
| 1996 |
Jideama NM, Noland TA, Raynor RL, Blobe GC, Fabbro D, Kazanietz MG, Blumberg PM, Hannun YA, Kuo JF. Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. The Journal of Biological Chemistry. 271: 23277-83. PMID 8798526 DOI: 10.1074/Jbc.271.38.23277 |
0.363 |
|
| 1996 |
Farkas-Szallasi T, Bennett GJ, Blumberg PM, Hökfelt T, Lundberg JM, Szallasi A. Vanilloid receptor loss is independent of the messenger plasticity that follows systemic resiniferatoxin administration. Brain Research. 719: 213-8. PMID 8782884 DOI: 10.1016/0006-8993(96)00065-0 |
0.319 |
|
| 1996 |
Acs G, Lee J, Marquez VE, Blumberg PM. Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes. Brain Research. Molecular Brain Research. 35: 173-82. PMID 8717353 DOI: 10.1016/0169-328X(95)00204-6 |
0.386 |
|
| 1996 |
Szallasi Z, Bogi K, Gohari S, Biro T, Acs P, Blumberg PM. Non-equivalent roles for the first and second zinc fingers of protein kinase Cdelta. Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells. The Journal of Biological Chemistry. 271: 18299-301. PMID 8702464 DOI: 10.1074/Jbc.271.31.18299 |
0.346 |
|
| 1996 |
Wang S, Kazanietz MG, Blumberg PM, Marquez VE, Milne GW. Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C. Journal of Medicinal Chemistry. 39: 2541-53. PMID 8691452 DOI: 10.1021/Jm950403N |
0.445 |
|
| 1996 |
Lee J, Sharma R, Wang S, Milne GW, Lewin NE, Szallasi Z, Blumberg PM, George C, Marquez VE. Conformationally constrained analogues of diacylglycerol. 12. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4-lactone template. Journal of Medicinal Chemistry. 39: 36-45. PMID 8568825 DOI: 10.1021/Jm950278F |
0.434 |
|
| 1996 |
Lee J, Wang S, Milne GW, Sharma R, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 11. Ultrapotent protein kinase C ligands based on a chiral 5-disubstituted tetrahydro-2-furanone template. Journal of Medicinal Chemistry. 39: 29-35. PMID 8568819 DOI: 10.1021/Jm950277N |
0.434 |
|
| 1996 |
Sharma R, Lee J, Wang S, Milne GW, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 10. Ultrapotent protein kinase C ligands based on a racemic 5-disubstituted tetrahydro-2-furanone template. Journal of Medicinal Chemistry. 39: 19-28. PMID 8568806 DOI: 10.1021/Jm950276V |
0.414 |
|
| 1995 |
Wang S, Zaharevitz DW, Sharma R, Marquez VE, Lewin NE, Du L, Blumberg PM, Milne GW. The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database pharmacophore search. Molecular modeling studies. Journal of Medicinal Chemistry. 37: 4479-89. PMID 7799398 DOI: 10.1021/Jm00052A007 |
0.448 |
|
| 1995 |
Acs G, Lee J, Marquez VE, Wang S, Milne GW, Du L, Lewin NE, Blumberg PM. Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids. Journal of Neurochemistry. 65: 301-18. PMID 7790875 DOI: 10.1046/J.1471-4159.1995.65010301.X |
0.475 |
|
| 1995 |
Blumberg PM, Acs G, Acs P, Areces LB, Kazanietz MG, Lewin NE, Szallasi Z. Protein kinase C in cell signaling: strategies for the development of selective inhibitors. Agents and Actions. Supplements. 47: 87-100. PMID 7785505 DOI: 10.1007/978-3-0348-7343-7_7 |
0.337 |
|
| 1995 |
Kazanietz MG, Barchi JJ, Omichinski JG, Blumberg PM. Low affinity binding of phorbol esters to protein kinase C and its recombinant cysteine-rich region in the absence of phospholipids Journal of Biological Chemistry. 270: 14679-14684. PMID 7782331 DOI: 10.1074/Jbc.270.24.14679 |
0.477 |
|
| 1995 |
Zhang G, Kazanietz MG, Blumberg PM, Hurley JH. Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell. 81: 917-24. PMID 7781068 DOI: 10.1016/0092-8674(95)90011-X |
0.446 |
|
| 1995 |
Kazanietz MG, Wang S, Milne GW, Lewin NE, Liu HL, Blumberg PM. Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis. The Journal of Biological Chemistry. 270: 21852-9. PMID 7665608 DOI: 10.1074/Jbc.270.37.21852 |
0.438 |
|
| 1995 |
Lehel C, Oláh Z, Jakab G, Szállási Z, Petrovics G, Harta G, Blumberg PM, Anderson WB. Protein kinase C epsilon subcellular localization domains and proteolytic degradation sites. A model for protein kinase C conformational changes. The Journal of Biological Chemistry. 270: 19651-8. PMID 7642654 DOI: 10.1074/Jbc.270.33.19651 |
0.395 |
|
| 1995 |
Szallasi A, Blumberg PM, Lundberg JM. Proton inhibition of [3H]resiniferatoxin binding to vanilloid (capsaicin) receptors in rat spinal cord. European Journal of Pharmacology. 289: 181-7. PMID 7621890 DOI: 10.1016/0922-4106(95)90093-4 |
0.33 |
|
| 1995 |
Szallasi Z, Denning MF, Chang EY, Rivera J, Yuspa SH, Lehel C, Olah Z, Anderson WB, Blumberg PM. Development of a rapid approach to identification of tyrosine phosphorylation sites: Application to PKCδ phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells Biochemical and Biophysical Research Communications. 214: 888-894. PMID 7575560 DOI: 10.1006/Bbrc.1995.2370 |
0.397 |
|
| 1995 |
Haleem-Smith H, Chang EY, Szallasi Z, Blumberg PM, Rivera J. Tyrosine phosphorylation of protein kinase C-delta in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition. Proceedings of the National Academy of Sciences of the United States of America. 92: 9112-6. PMID 7568083 DOI: 10.1073/PNAS.92.20.9112 |
0.309 |
|
| 1995 |
Kazanietz MG, Lewin NE, Bruns JD, Blumberg PM. Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity. The Journal of Biological Chemistry. 270: 10777-83. PMID 7537738 DOI: 10.1074/Jbc.270.18.10777 |
0.47 |
|
| 1995 |
Acs P, Szallasi Z, Kazanietz MG, Blumberg PM. Differential activation of PKC isozymes by 14-3-3 zeta protein. Biochemical and Biophysical Research Communications. 216: 103-9. PMID 7488074 DOI: 10.1006/Bbrc.1995.2597 |
0.418 |
|
| 1995 |
Winkler JD, Hong B, Kim S, Lewin NE, Blumberg PM. On the Protein Kinase C Pharmacophore: Synthesis and Biological Activity of 4-Hydroxylated Analogs of Ingenol Synlett. 1995: 533-535. DOI: 10.1055/S-1995-5288 |
0.417 |
|
| 1995 |
Winkler JD, Hong B, Bahador A, Kazanietz MG, Blumberg PM. Inside-outside stereoisomerism. VII. Methodology for the Synthesis of 3-Oxygenated Ingenanes. The First Ingenol Analogs with High Affinity for Protein Kinase C The Journal of Organic Chemistry. 60: 1381-1390. DOI: 10.1021/Jo00110A048 |
0.394 |
|
| 1995 |
Kozikowski AP, Ma D, Du L, Lewin NE, Blumberg PM. Effect of Alteration of the Heterocyclic Nucleus of Indolactam V on Its Isoform Selectivity for PKC. Palladium-Catalyzed Route to Benzofuran Analogs of ILV Journal of the American Chemical Society. 117: 6666-6672. DOI: 10.1021/Ja00130A003 |
0.409 |
|
| 1995 |
Lee J, Acs G, Blumberg PM, Marquez VE. Thiourea analogues of resiniferatoxin as ligands for the vanilloid receptor Bioorganic & Medicinal Chemistry Letters. 5: 1331-1334. DOI: 10.1016/0960-894X(95)00217-H |
0.309 |
|
| 1994 |
Goso C, Evangelista S, Tramontana M, Manzini S, Blumberg PM, Szallasi A. Topical capsaicin administration protects against trinitrobenzene sulfonic acid-induced colitis in the rat. European Journal of Pharmacology. 249: 185-90. PMID 8287899 DOI: 10.1016/0014-2999(93)90431-G |
0.334 |
|
| 1994 |
Wang S, Milne GW, Nicklaus MC, Marquez VE, Lee J, Blumberg PM. Protein kinase C. Modeling of the binding site and prediction of binding constants. Journal of Medicinal Chemistry. 37: 1326-38. PMID 8176711 DOI: 10.1021/Jm00035A013 |
0.374 |
|
| 1994 |
Acs G, Palkovits M, Blumberg PM. Comparison of [3H]resiniferatoxin binding by the vanilloid (capsaicin) receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat. Life Sciences. 55: 1017-26. PMID 8084206 DOI: 10.1016/0024-3205(94)00636-9 |
0.349 |
|
| 1994 |
Lee J, Marquez VE, Blumberg PM, Krausz KW, Kazanietz MG. Conformationally constrained analogues of diacylglycerol (DAG)--II. Differential interaction of delta-lactones and gamma-lactones with protein kinase C (PK-C). Bioorganic & Medicinal Chemistry. 1: 119-23. PMID 8081841 DOI: 10.1016/S0968-0896(00)82109-4 |
0.342 |
|
| 1994 |
Razin E, Szallasi Z, Kazanietz MG, Blumberg PM, Rivera J. Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun. Proceedings of the National Academy of Sciences of the United States of America. 91: 7722-6. PMID 8052650 DOI: 10.1073/Pnas.91.16.7722 |
0.416 |
|
| 1994 |
Acs G, Blumberg PM. [3H]resiniferatoxin binding to pig dorsal horn membranes displays positive cooperativity. Life Sciences. 55: 337-46. PMID 8035647 DOI: 10.1016/0024-3205(94)00643-1 |
0.341 |
|
| 1994 |
Szallasi A, Blumberg PM, Nilsson S, Hökfelt T, Lundberg JM. Visualization by [3H]resiniferatoxin autoradiography of capsaicin-sensitive neurons in the rat, pig and man. European Journal of Pharmacology. 264: 217-21. PMID 7851486 DOI: 10.1016/0014-2999(94)00526-5 |
0.314 |
|
| 1994 |
Kozikowski AP, Ma D, Du L, Lewin NE, Blumberg PM. A palladium catalyzed route to a benzofuran analogue of idolactam V (ILV): Effects on PKC isotype selectivity Pure and Applied Chemistry. 66: 2087-2090. DOI: 10.1351/Pac199466102087 |
0.314 |
|
| 1994 |
Lee J, Marquez VE, Lewin NE, Blumberg PM. Synthesis of two Rigid Diacylglycerol Analogues Having a 1,7-Dioxasjuro[4.4]nonane Bis-γ-butyrolactone Skeleton.4.1 Synlett. 1994: 206-208. DOI: 10.1055/S-1994-22796 |
0.377 |
|
| 1994 |
Wang S, Milne GWA, Nicklaus MC, Marquez VE, Lee J, Blumberg PM. Protein Kinase C. Modeling of the Binding Site and Prediction of Binding Constants. [Erratum to document cited in CA121:29778] Journal of Medicinal Chemistry. 37: 4422-4422. DOI: 10.1021/Jm00051A022 |
0.392 |
|
| 1994 |
Lee J, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 9.1 the effect of side-chain orientation on the protein kinase C (PK-C) binding affinity of σ-lactones Bioorganic & Medicinal Chemistry Letters. 4: 2405-2410. DOI: 10.1016/S0960-894X(01)80399-1 |
0.385 |
|
| 1994 |
Lee J, Sharma R, Teng K, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of dag .8. Changes in PK-C binding affinity produced by isosteric groups of the 3-O-acyl function in 2-deoxy-L-ribonolactones Bioorganic & Medicinal Chemistry Letters. 4: 1369-1374. DOI: 10.1016/S0960-894X(01)80364-4 |
0.359 |
|
| 1994 |
Kozikowski AP, Ma D, Du L, Lewin NE, Blumberg PM. Synthesis of the benzofuran analogue of ILV, a new protein kinase C (PKC) activator Bioorganic & Medicinal Chemistry Letters. 4: 637-640. DOI: 10.1016/S0960-894X(01)80169-4 |
0.391 |
|
| 1994 |
Lee J, Marquez VE, Lewin NE, Blumberg PM. Conformationally constrained analogues of DAG.7. Interaction of a medium-size ε-lactone with protein kinase C (PK-C)_ Bioorganic & Medicinal Chemistry Letters. 4: 543-548. DOI: 10.1016/S0960-894X(01)80151-7 |
0.426 |
|
| 1994 |
Marquez VE, Lee J, Sharma R, Teng K, Wang S, Lewin NE, Bahador A, Kazanietz MG, Blumberg PM. Conformationally constrained analogues of diacylglycerol. 6. Changes in PK-C binding affinity for 3-O-acyl-2-deoxy-L-ribonolactones bearing different acyl chains. Bioorganic & Medicinal Chemistry Letters. 4: 355-360. DOI: 10.1016/S0960-894X(01)80144-X |
0.338 |
|
| 1993 |
Szallasi A, Blumberg PM. Mechanisms and therapeutic potential of vanilloids (capsaicin-like molecules). Advances in Pharmacology (San Diego, Calif.). 24: 123-55. PMID 8504062 DOI: 10.1016/S1054-3589(08)60936-9 |
0.332 |
|
| 1993 |
Szallasi A, Conte B, Goso C, Blumberg PM, Manzini S. Characterization of a peripheral vanilloid (capsaicin) receptor in the urinary bladder of the rat. Life Sciences. 52: PL221-6. PMID 8483387 DOI: 10.1016/0024-3205(93)90051-4 |
0.325 |
|
| 1993 |
Szallasi A, Blumberg PM. [3H]resiniferatoxin binding by the vanilloid receptor: species-related differences, effects of temperature and sulfhydryl reagents. Naunyn-Schmiedeberg's Archives of Pharmacology. 347: 84-91. PMID 8446186 DOI: 10.1007/Bf00168777 |
0.395 |
|
| 1993 |
Szallasi A, Conte B, Goso C, Blumberg PM, Manzini S. Vanilloid receptors in the urinary bladder: regional distribution, localization on sensory nerves, and species-related differences. Naunyn-Schmiedeberg's Archives of Pharmacology. 347: 624-9. PMID 7689705 DOI: 10.1007/Bf00166945 |
0.353 |
|
| 1993 |
Winkler JD, Hong BC, Bahador A, Kazanietz MG, Blumberg PM. Synthesis of ingenol analogs wth affinity for protein kinase C Bioorganic and Medicinal Chemistry Letters. 3: 577-580. DOI: 10.1016/S0960-894X(01)81232-4 |
0.431 |
|
| 1993 |
Sharma R, Marquez VE, Milne GW, Lewin NE, Blumberg PM. Conformationally constrained analogues of diacylglycerol. 5. 2,5-Dideoxy-3-O-tetradecanoyl-D-galactono-1,4-lactone: A superior homologue of 3-O-tetradecanoyl-2-deoxy-L-ribonolactone with PK-C binding affinity. Bioorganic & Medicinal Chemistry Letters. 3: 1993-1998. DOI: 10.1016/S0960-894X(01)81002-7 |
0.317 |
|
| 1993 |
Lee J, Marquez VE, Lewin NE, Kazanietz MG, Bahador A, Blumberg PM. Conformationally constrained analogues of diacylglycerol (DAG). 3. Interaction of α-alkyl-γ-lactones with protein kinase C (PK-C) Bioorganic & Medicinal Chemistry Letters. 3: 1101-1106. DOI: 10.1016/S0960-894X(00)80295-4 |
0.456 |
|
| 1993 |
Lee J, Marquez VE, Lewin NE, Blumberg PM. Synthesis of two rigid diacylglycerol analogues having a perhydro furo[34-b]furan bis-γ-butyrolactone skeleton. 2. Tetrahedron Letters. 34: 4313-4316. DOI: 10.1016/S0040-4039(00)79337-3 |
0.335 |
|
| 1992 |
Szallasi A, Szolcsanyi J, Szallasi Z, Blumberg PM. Inhibition of [3H]resiniferatoxin binding to rat dorsal root ganglion membranes as a novel approach in evaluating compounds with capsaicin-like activity. Naunyn-Schmiedeberg's Archives of Pharmacology. 344: 551-6. PMID 1811172 DOI: 10.1007/Bf00170651 |
0.382 |
|
| 1992 |
Gustafson KR, Cardellina JH, McMahon JB, Gulakowski RJ, Ishitoya J, Szallasi Z, Lewin NE, Blumberg PM, Weislow OS, Beutler JA. A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. Journal of Medicinal Chemistry. 35: 1978-86. PMID 1597853 DOI: 10.1021/Jm00089A006 |
0.347 |
|
| 1992 |
Lewin NE, Dell'Aquila ML, Pettit GR, Blumberg PM, Warren BS. Binding of [3H]bryostatin 4 to protein kinase C. Biochemical Pharmacology. 43: 2007-14. PMID 1596288 DOI: 10.1016/0006-2952(92)90644-X |
0.414 |
|
| 1992 |
Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF, Mischak H. The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta. Gene. 122: 305-11. PMID 1487145 DOI: 10.1016/0378-1119(92)90219-F |
0.34 |
|
| 1992 |
Szallasi A, Blumberg PM. Vanilloid receptor loss in rat sensory ganglia associated with long term desensitization to resiniferatoxin. Neuroscience Letters. 140: 51-4. PMID 1407700 DOI: 10.1016/0304-3940(92)90679-2 |
0.329 |
|
| 1992 |
Szallasi Z, Krausz KW, Blumberg PM. Non-promoting 12-deoxyphorbol 13-esters as potent inhibitors of phorbol 12-myristate 13-acetate-induced acute and chronic biological responses in CD-1 mouse skin. Carcinogenesis. 13: 2161-7. PMID 1385002 DOI: 10.1093/Carcin/13.11.2161 |
0.365 |
|
| 1992 |
Meini S, Evangelista S, Geppetti P, Szallasi A, Blumberg PM, Manzini S. Pharmacologic and neurochemical evidence for the activation of capsaicin-sensitive sensory nerves by lipoxin A4 in guinea pig bronchus. The American Review of Respiratory Disease. 146: 930-4. PMID 1384407 DOI: 10.1164/Ajrccm/146.4.930 |
0.335 |
|
| 1992 |
Teng K, Marquez VE, Milne GWA, Barchi JJ, Kazanietz MG, Lewin NE, Blumberg PM, Abushanab E. Conformationally constrained analogs of diacylglycerol. Interaction of .gamma.-lactones with the phorbol ester receptor of protein kinase C Journal of the American Chemical Society. 114: 1059-1070. DOI: 10.1021/Ja00029A039 |
0.415 |
|
| 1992 |
Teng K, Marquez VE, Milne GWA, Barchi JJ, Kazanietz MG, Lewin NE, Blumberg PM, Abushanab E. Conformationally constrained analogues of diacylglycerol. Interaction of γ-lactones with the phorbol ester receptor of protein kinase C Journal of the American Chemical Society. 114: 1059-1070. |
0.303 |
|
| 1991 |
Szallasi A, Blumberg PM. Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sciences. 47: 1399-408. PMID 2174484 DOI: 10.1016/0024-3205(90)90518-V |
0.395 |
|
| 1991 |
Lewin NE, Pettit GR, Kamano Y, Blumberg PM. Binding of [26-3H]-epi-bryostatin 4 to protein kinase C. Cancer Communications. 3: 67-70. PMID 2001329 DOI: 10.3727/095535491820873506 |
0.454 |
|
| 1991 |
Blumberg PM. Complexities of the protein kinase C pathway. Molecular Carcinogenesis. 4: 339-44. PMID 1910477 DOI: 10.1002/Mc.2940040502 |
0.363 |
|
| 1991 |
Szallasi A, Blumberg PM. Characterization of vanilloid receptors in the dorsal horn of pig spinal cord. Brain Research. 547: 335-8. PMID 1884211 DOI: 10.1016/0006-8993(91)90982-2 |
0.378 |
|
| 1991 |
Szallasi A, Blumberg PM. Molecular target size of the vanilloid (capsaicin) receptor in pig dorsal root ganglia. Life Sciences. 48: 1863-9. PMID 1645836 DOI: 10.1016/0024-3205(91)90242-4 |
0.313 |
|
| 1990 |
Nakakuma H, Willingham MC, Blumberg PM. Effect of microinjected catalytic fragment of protein kinase C on morphological change in Swiss 3T3 cells. Cancer Communications. 1: 127-32. PMID 2700912 DOI: 10.3727/095535489820875336 |
0.409 |
|
| 1990 |
Szallasi A, Blumberg PM. Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes. Brain Research. 524: 106-11. PMID 2400923 DOI: 10.1016/0006-8993(90)90498-Z |
0.386 |
|
| 1989 |
Tauber AI, Cox JA, Curnutte JT, Carrol PM, Nakakuma H, Warren B, Gilbert H, Blumberg PM. Activation of human neutrophil NADPH-oxidase in vitro by the catalytic fragment of protein kinase-C. Biochemical and Biophysical Research Communications. 158: 884-90. PMID 2920044 DOI: 10.1016/0006-291X(89)92805-2 |
0.381 |
|
| 1989 |
Szallasi A, Sharkey NA, Blumberg PM. Structure/activity analysis of resiniferatoxin analogs Phytotherapy Research. 3: 253-257. DOI: 10.1002/Ptr.2650030607 |
0.417 |
|
| 1988 |
de Vries DJ, Herald CL, Pettit GR, Blumberg PM. Demonstration of sub-nanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain. Biochemical Pharmacology. 37: 4069-73. PMID 3190746 DOI: 10.1016/0006-2952(88)90097-4 |
0.409 |
|
| 1988 |
Wender PA, Cribbs CM, Koehler KF, Sharkey NA, Herald CL, Kamano Y, Pettit GR, Blumberg PM. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 85: 7197-201. PMID 3174627 DOI: 10.1073/Pnas.85.19.7197 |
0.318 |
|
| 1988 |
Nakadate T, Jeng AY, Blumberg PM. Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action. Biochemical Pharmacology. 37: 1541-5. PMID 3162795 DOI: 10.1016/0006-2952(88)90016-0 |
0.316 |
|
| 1987 |
Hennings H, Blumberg PM, Pettit GR, Herald CL, Shores R, Yuspa SH. Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis. 8: 1343-6. PMID 3621472 DOI: 10.1093/Carcin/8.9.1343 |
0.368 |
|
| 1987 |
Jeng AY, Srivastava SK, Lacal JC, Blumberg PM. Phosphorylation of ras oncogene product by protein kinase C. Biochemical and Biophysical Research Communications. 145: 782-8. PMID 3496094 DOI: 10.1016/0006-291X(87)91033-3 |
0.383 |
|
| 1987 |
Pasti G, Lacal JC, Warren BS, Aaronson SA, Blumberg PM. Loss of mouse fibroblast cell response to phorbol esters restored by microinjected protein kinase C. Nature. 324: 375-7. PMID 3466038 DOI: 10.1038/324375A0 |
0.455 |
|
| 1987 |
Lacal JC, Fleming TP, Warren BS, Blumberg PM, Aaronson SA. Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product Molecular and Cellular Biology. 7: 4146-4149. PMID 3323889 DOI: 10.1128/Mcb.7.11.4146 |
0.355 |
|
| 1987 |
Leach KL, Frost MM, Blumberg PM, Bressler JP. Second stage tumor promoters: Differences in biological potency and phorbol ester receptor affinity in C6 cells Cancer Letters. 36: 139-147. PMID 3040225 DOI: 10.1016/0304-3835(87)90085-1 |
0.432 |
|
| 1987 |
BLUMBERG PM, NAKADATE T, WARREN BS, DELL'AQUILA M, SAKO T, PASTI G, SHARKEY NA. Phorbol esters as probes of the modulatory site on protein kinase C–an overview Botanical Journal of the Linnean Society. 94: 283-292. DOI: 10.1111/J.1095-8339.1987.Tb01051.X |
0.401 |
|
| 1987 |
Yeh E, Sharkey NA, Blumberg PM. Influence of side chains on phorbol ester binding to protein kinase C Phytotherapy Research. 1: 135-139. DOI: 10.1002/Ptr.2650010308 |
0.475 |
|
| 1986 |
Sharkey NA, Blumberg PM. Short communication: Comparison of the activity of phorbol 12-myristate 13-acetate and the diglyceride glycerol 1-myristate 2-acetate Carcinogenesis. 7: 677-679. PMID 3486050 DOI: 10.1093/Carcin/7.4.677 |
0.473 |
|
| 1986 |
Wender PA, Koehler KF, Sharkey NA, Dell'Aquila ML, Blumberg PM. Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs. Proceedings of the National Academy of Sciences of the United States of America. 83: 4214-8. PMID 3086877 DOI: 10.1073/Pnas.83.12.4214 |
0.484 |
|
| 1985 |
Blumberg PM, Leach KL, König B, Jeng AY, Sharkey NA. Receptors for the phorbol ester tumour promoters Ciba Foundation Symposium. 116: 205-223. PMID 4075903 DOI: 10.1002/9780470720974.ch13 |
0.376 |
|
| 1985 |
König B, DiNitto PA, Blumberg PM. Stoichiometric binding of diacylglycerol to the phorbol ester receptor. Journal of Cellular Biochemistry. 29: 37-44. PMID 4055921 DOI: 10.1002/Jcb.240290105 |
0.452 |
|
| 1985 |
Sharkey NA, Blumberg PM. Kinetic evidence that 1,2-diolein inhibits phorbol ester binding to protein kinase C via a competitive mechanism Biochemical and Biophysical Research Communications. 133: 1051-1056. PMID 3936500 DOI: 10.1016/0006-291X(85)91242-2 |
0.452 |
|
| 1985 |
König B, Di Nitto PA, Blumberg PM. Phospholipid and Ca++ dependency of phorbol ester receptors. Journal of Cellular Biochemistry. 27: 255-65. PMID 3157693 DOI: 10.1002/Jcb.240270307 |
0.46 |
|
| 1985 |
Cox JA, Jeng AY, Sharkey NA, Blumberg PM, Tauber AI. Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C Journal of Clinical Investigation. 76: 1932-1938. PMID 2997297 DOI: 10.1172/Jci112190 |
0.319 |
|
| 1984 |
Blumberg PM, Jaken S, König B, Sharkey NA, Leach KL, Jeng AY, Yeh E. Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands Biochemical Pharmacology. 33: 933-940. PMID 6324806 DOI: 10.1016/0006-2952(84)90448-9 |
0.47 |
|
| 1984 |
Sharkey NA, Leach KL, Blumberg PM. Competitive inhibition by diacylglycerol of specific phorbol ester binding Proceedings of the National Academy of Sciences of the United States of America. 81: 607-610. PMID 6320198 DOI: 10.1073/Pnas.81.2.607 |
0.433 |
|
| 1983 |
Leach KL, James ML, Blumberg PM. Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol Proceedings of the National Academy of Sciences of the United States of America. 80: 4208-4212. PMID 6308606 DOI: 10.1073/Pnas.80.14.4208 |
0.368 |
|
| 1982 |
Burstein DE, Blumberg PM, Greene LA. Nerve growth factor-induced neuronal differentiation of PC12 pheochromocytoma cells: Lack of inhibition by a tumor promoter Brain Research. 247: 115-119. PMID 7127107 DOI: 10.1016/0006-8993(82)91033-2 |
0.304 |
|
| 1982 |
Tauber AI, Brettler DB, Kennington EA, Blumberg PM. Relation of human neutrophil phorbol ester receptor occupancy and NADPH-oxidase activity Blood. 60: 333-339. PMID 6953983 DOI: 10.1182/Blood.V60.2.333.333 |
0.374 |
|
| 1980 |
Driedger PE, Blumberg PM. Specific binding of phorbol ester tumor promoters. Proceedings of the National Academy of Sciences of the United States of America. 77: 567-71. PMID 6965793 DOI: 10.1073/Pnas.77.1.567 |
0.359 |
|
| 1978 |
McConnell MR, Blumberg PM. SUBUNIT STRUCTURE OF SURFACE AND SHED LARGE, EXTERNAL, TRANSFORMATION-SENSITIVE PROTEIN OF CHICK EMBRYO FIBROBLASTS Annals of the New York Academy of Sciences. 312: 418-419. DOI: 10.1111/J.1749-6632.1978.Tb16823.X |
0.646 |
|
| 1975 |
Blumberg PM, Strominger JL. Covalent affinity chromatography of penicillin-binding components from bacterial membranes. Methods in Enzymology. 34: 401-5. PMID 4217420 DOI: 10.1016/S0076-6879(74)34046-3 |
0.312 |
|
| 1974 |
Anwar RA, Blumberg PM, Strominger JL. Penicillin binding components in Bacillus subtilis during sporulation Journal of Bacteriology. 117: 924-925. PMID 4204446 DOI: 10.1128/Jb.117.2.924-925.1974 |
0.307 |
|
| 1973 |
Blumberg PM, Strominger JL. Isolation by covalent affinity chromatography of the penicillin-binding components from membranes of Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 69: 3751-5. PMID 4630162 DOI: 10.1073/Pnas.69.12.3751 |
0.316 |
|
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