Jason W. Locasale - Publications

Affiliations: 
Pharmacology and Cancer Biology Duke University, Durham, NC 
Area:
nutrition, chemistry, quantitative biology, metabolomics, epigenetics, cancer
Website:
http://jlocasale.duke.edu

88 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP, Ciccarella A, Calcagnotto A, Mikhael PG, Mentch SJ, Liu J, Ables G, Kirsch DG, Hsu DS, ... ... Locasale JW, et al. Dietary methionine influences therapy in mouse cancer models and alters human metabolism. Nature. PMID 31367041 DOI: 10.1038/s41586-019-1437-3  1
2019 Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, Locasale JW, Chang CY, McDonnell DP. Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Cell Reports. 27: 3587-3601.e4. PMID 31216477 DOI: 10.1016/j.celrep.2019.05.066  1
2019 Vodnala SK, Eil R, Kishton RJ, Sukumar M, Yamamoto TN, Ha NH, Lee PH, Shin M, Patel SJ, Yu Z, Palmer DC, Kruhlak MJ, Liu X, Locasale JW, Huang J, et al. T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science (New York, N.Y.). 363. PMID 30923193 DOI: 10.1126/science.aau0135  0.32
2019 Sinclair LV, Howden AJ, Brenes A, Spinelli L, Hukelmann JL, Macintyre AN, Liu X, Thomson S, Taylor PM, Rathmell JC, Locasale JW, Lamond AI, Cantrell DA. Antigen receptor control of methionine metabolism in T cells. Elife. 8. PMID 30916644 DOI: 10.7554/eLife.44210  0.32
2019 Yang Y, Ishak Gabra MB, Hanse EA, Lowman XH, Tran TQ, Li H, Milman N, Liu J, Reid MA, Locasale JW, Gil Z, Kong M. MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. Nature Communications. 10: 809. PMID 30778058 DOI: 10.1038/s41467-019-08759-0  1
2019 Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL, Hoehn KL, Rathmell JC, Bullock TNJ. Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8 T cells. Science Immunology. 4. PMID 30683669 DOI: 10.1126/sciimmunol.aap9520  0.32
2019 Hart PC, Chiyoda T, Liu X, Weigert M, Curtis M, Chiang CY, Loth R, Lastra R, McGregor SM, Locasale JW, Lengyel E, Romero IL. SPHK1 is a novel target of metformin in ovarian cancer. Molecular Cancer Research : McR. PMID 30655321 DOI: 10.1158/1541-7786.MCR-18-0409  0.32
2019 Ma H, Yu S, Liu X, Zhang Y, Fakadej T, Liu Z, Yin C, Shen W, Locasale JW, Taylor JM, Qian L, Liu J. Lin28a Regulates Pathological Cardiac Hypertrophic Growth through Pck2-Mediated Enhancement of Anabolic Synthesis. Circulation. PMID 30636447 DOI: 10.1161/CIRCULATIONAHA.118.037803  1
2018 Reid MA, Allen AE, Liu S, Liberti MV, Liu P, Liu X, Dai Z, Gao X, Wang Q, Liu Y, Lai L, Locasale JW. Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism. Nature Communications. 9: 5442. PMID 30575741 DOI: 10.1038/s41467-018-07868-6  1
2018 Stone OA, El-Brolosy M, Wilhelm K, Liu X, Romão AM, Grillo E, Lai JKH, Günther S, Jeratsch S, Kuenne C, Lee IC, Braun T, Santoro MM, Locasale JW, Potente M, et al. Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Nature Communications. 9: 4077. PMID 30301887 DOI: 10.1038/s41467-018-06406-8  0.32
2018 Liu X, Cooper DE, Cluntun AA, Warmoes MO, Zhao S, Reid MA, Liu J, Lund PJ, Lopes M, Garcia BA, Wellen KE, Kirsch DG, Locasale JW. Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals. Cell. PMID 30245009 DOI: 10.1016/j.cell.2018.08.040  1
2018 Curtis M, Kenny HA, Ashcroft B, Mukherjee A, Johnson A, Zhang Y, Helou Y, Batlle R, Liu X, Gutierrez N, Gao X, Yamada SD, Lastra R, Montag A, Ahsan N, ... Locasale JW, et al. Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metabolism. PMID 30174305 DOI: 10.1016/j.cmet.2018.08.007  0.32
2018 Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X. p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. Molecular Cell. 70: 984. PMID 29883613 DOI: 10.1016/j.molcel.2018.05.035  0.32
2018 Bechard ME, Word AE, Tran AV, Liu X, Locasale JW, McDonald OG. Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases. Oncogene. PMID 29849117 DOI: 10.1038/s41388-018-0346-5  0.32
2018 Chapman NM, Zeng H, Nguyen TM, Wang Y, Vogel P, Dhungana Y, Liu X, Neale G, Locasale JW, Chi H. mTOR coordinates transcriptional programs and mitochondrial metabolism of activated T subsets to protect tissue homeostasis. Nature Communications. 9: 2095. PMID 29844370 DOI: 10.1038/s41467-018-04392-5  0.32
2018 Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X. EP300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. Molecular Cell. 70: 663-678.e6. PMID 29775581 DOI: 10.1016/j.molcel.2018.04.011  0.32
2018 Yan W, Wu X, Zhou W, Fong MY, Cao M, Liu J, Liu X, Chen CH, Fadare O, Pizzo DP, Wu J, Liu L, Liu X, Chin AR, Ren X, ... ... Locasale JW, et al. Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nature Cell Biology. PMID 29662176 DOI: 10.1038/s41556-018-0083-6  1
2018 Gao X, Lee K, Reid MA, Sanderson SM, Qiu C, Li S, Liu J, Locasale JW. Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism. Cell Reports. 22: 3507-3520. PMID 29590619 DOI: 10.1016/j.celrep.2018.03.017  1
2018 Zhao F, Xiao C, Evans KS, Theivanthiran T, DeVito N, Holtzhausen A, Liu J, Liu X, Boczkowski D, Nair S, Locasale JW, Hanks BA. Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization. Immunity. 48: 147-160.e7. PMID 29343435 DOI: 10.1016/j.immuni.2017.12.004  1
2017 Glass OK, Bowie M, Fuller J, Darr D, Usary J, Boss K, Choudhury KR, Liu X, Zhang Z, Locasale JW, Williams C, Dewhirst MW, Jones LW, Seewaldt V. Differential response to exercise in claudin-low breast cancer. Oncotarget. 8: 100989-101004. PMID 29254140 DOI: 10.18632/oncotarget.21054  0.32
2017 Singleton KR, Crawford L, Tsui E, Manchester HE, Maertens O, Liu X, Liberti MV, Magpusao AN, Stein EM, Tingley JP, Frederick DT, Boland GM, Flaherty KT, McCall SJ, Krepler C, ... ... Locasale JW, et al. Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence. Cell Reports. 21: 2796-2812. PMID 29212027 DOI: 10.1016/j.celrep.2017.11.022  0.32
2017 Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, ... ... Locasale JW, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metabolism. PMID 28918937 DOI: 10.1016/j.cmet.2017.08.017  0.32
2017 Liu X, Locasale JW. Biochemistry: A toxin that fuels metabolism. Nature. PMID 28813408 DOI: 10.1038/nature23541  0.32
2017 Martin AS, Abraham DM, Hershberger KA, Bhatt DP, Mao L, Cui H, Liu J, Liu X, Muehlbauer MJ, Grimsrud PA, Locasale JW, Payne RM, Hirschey MD. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model. Jci Insight. 2. PMID 28724806 DOI: 10.1172/jci.insight.93885  1
2017 Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, ... ... Locasale JW, et al. Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis. Nature Cell Biology. 19: 873. PMID 28659639 DOI: 10.1038/ncb3558  0.32
2017 Garcia J, Bagwell J, Njaine B, Norman J, Levic DS, Wopat S, Miller SE, Liu X, Locasale JW, Stainier DYR, Bagnat M. Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord. Current Biology : Cb. PMID 28648824 DOI: 10.1016/j.cub.2017.05.035  0.32
2017 Liu X, Locasale JW. Metabolomics reveals intratumor heterogeneity - Implications for precision medicine. Ebiomedicine. PMID 28457617 DOI: 10.1016/j.ebiom.2017.04.030  0.32
2017 Cluntun AA, Lukey MJ, Cerione RA, Locasale JW. Glutamine Metabolism in Cancer: Understanding the Heterogeneity. Trends in Cancer. 3: 169-180. PMID 28393116 DOI: 10.1016/j.trecan.2017.01.005  0.52
2017 Wang X, Yang K, Xie Q, Wu Q, Mack SC, Shi Y, Kim LJ, Prager BC, Flavahan WA, Liu X, Singer M, Hubert CG, Miller TE, Zhou W, Huang Z, ... ... Locasale JW, et al. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nature Neuroscience. PMID 28346452 DOI: 10.1038/nn.4537  0.32
2017 Liu X, Locasale JW. Metabolomics: A Primer. Trends in Biochemical Sciences. PMID 28196646 DOI: 10.1016/j.tibs.2017.01.004  0.32
2017 McDonald OG, Li X, Saunders T, Tryggvadottir R, Mentch SJ, Warmoes MO, Word AE, Carrer A, Salz TH, Natsume S, Stauffer KM, Makohon-Moore A, Zhong Y, Wu H, Wellen KE, ... Locasale JW, et al. Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. Nature Genetics. PMID 28092686 DOI: 10.1038/ng.3753  1
2016 Liu X, Romero IL, Litchfield LM, Lengyel E, Locasale JW. Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers. Cell Metabolism. PMID 27746051 DOI: 10.1016/j.cmet.2016.09.005  0.32
2016 Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H. mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. Immunity. PMID 27637146 DOI: 10.1016/j.immuni.2016.08.017  1
2016 Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W, Song C, Xu X, Schones DE, Ann DK, ... ... Locasale JW, et al. Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nature Cell Biology. PMID 27617932 DOI: 10.1038/ncb3410  1
2016 Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M. IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes & Development. PMID 27585591 DOI: 10.1101/gad.287235.116  1
2016 Ser Z, Gao X, Johnson C, Mehrmohamadi M, Liu X, Li S, Locasale JW. Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow. Cell Reports. PMID 27264180 DOI: 10.1016/j.celrep.2016.05.035  0.32
2016 Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, ... ... Locasale JW, et al. The metabolic co-regulator PGC1α suppresses prostate cancer metastasis. Nature Cell Biology. PMID 27214280 DOI: 10.1038/ncb3357  1
2016 Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, ... ... Locasale JW, et al. AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell Metabolism. 23: 649-62. PMID 27076078 DOI: 10.1016/j.cmet.2016.03.008  1
2016 Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H. Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proceedings of the National Academy of Sciences of the United States of America. PMID 27051063 DOI: 10.1073/pnas.1519858113  1
2016 Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP. ERRα Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Reports. PMID 27050525 DOI: 10.1016/j.celrep.2016.03.026  1
2016 Niewiadomski J, Zhou JQ, Roman HB, Liu X, Hirschberger LL, Locasale JW, Stipanuk MH. Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. Annals of the New York Academy of Sciences. 1363: 99-115. PMID 26995761 DOI: 10.1111/nyas.13021  0.32
2016 Sumita K, Lo YH, Takeuchi K, Senda M, Kofuji S, Ikeda Y, Terakawa J, Sasaki M, Yoshino H, Majd N, Zheng Y, Kahoud ER, Yokota T, Emerling BM, Asara JM, ... ... Locasale JW, et al. The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. Molecular Cell. 61: 187-98. PMID 26774281 DOI: 10.1016/j.molcel.2015.12.011  1
2015 Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, ... ... Locasale JW, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Seminars in Cancer Biology. 35: S276-304. PMID 26590477 DOI: 10.1016/j.semcancer.2015.09.007  1
2015 Jurkowska H, Niewiadomski J, Hirschberger LL, Roman HB, Mazor KM, Liu X, Locasale JW, Park E, Stipanuk MH. Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo. Amino Acids. PMID 26481005 DOI: 10.1007/s00726-015-2108-9  0.32
2015 Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002  1
2015 Mentch SJ, Mehrmohamadi M, Huang L, Liu X, Gupta D, Mattocks D, Gómez Padilla P, Ables G, Bamman MM, Thalacker-Mercer AE, Nichenametla SN, Locasale JW. Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. Cell Metabolism. PMID 26411344 DOI: 10.1016/j.cmet.2015.08.024  0.32
2015 Cluntun AA, Huang H, Dai L, Liu X, Zhao Y, Locasale JW. The rate of glycolysis quantitatively mediates specific histone acetylation sites. Cancer & Metabolism. 3: 10. PMID 26401273 DOI: 10.1186/s40170-015-0135-3  1
2015 Barker BE, Sadagopan N, Wang Y, Smallbone K, Myers CR, Xi H, Locasale JW, Gu Z. A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data. Computational Biology and Chemistry. PMID 26381164 DOI: 10.1016/j.compbiolchem.2015.08.002  1
2015 Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, et al. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. PMID 26321681 DOI: 10.1016/j.cell.2015.08.012  1
2015 Colak G, Pougovkina O, Dai L, Tan M, Te Brinke H, Huang H, Cheng Z, Park J, Wan X, Liu X, Yue WW, Wanders RJ, Locasale JW, Lombard DB, de Boer VC, et al. Proteomic and biochemical studies of lysine malonylation suggests its malonic aciduria-associated regulatory role in mitochondrial function and fatty acid oxidation. Molecular & Cellular Proteomics : McP. PMID 26320211 DOI: 10.1074/mcp.M115.048850  0.32
2015 Chourasia AH, Tracy K, Frankenberger C, Boland ML, Sharifi MN, Drake LE, Sachleben JR, Asara JM, Locasale JW, Karczmar GS, Macleod KF. Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. Embo Reports. 16: 1145-63. PMID 26232272 DOI: 10.15252/embr.201540759  0.32
2015 Douris N, Melman T, Pecherer JM, Pissios P, Flier JS, Cantley LC, Locasale JW, Maratos-Flier E. Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. Biochimica Et Biophysica Acta. 1852: 2056-65. PMID 26170063 DOI: 10.1016/j.bbadis.2015.07.009  1
2015 Liu X, Sadhukhan S, Sun S, Wagner GR, Hirschey MD, Qi L, Lin H, Locasale JW. High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet. Molecular & Cellular Proteomics : McP. 14: 1489-500. PMID 25795660 DOI: 10.1074/mcp.M114.044859  1
2015 Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, ... ... Locasale JW, et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology. 34: 189-201. PMID 25731751 DOI: 10.1016/j.copbio.2015.02.003  1
2015 Ser Z, Liu X, Tang NN, Locasale JW. Extraction parameters for metabolomics from cultured cells. Analytical Biochemistry. 475: 22-8. PMID 25613493 DOI: 10.1016/j.ab.2015.01.003  0.32
2015 Chen J, Lee HJ, Wu X, Huo L, Kim SJ, Xu L, Wang Y, He J, Bollu LR, Gao G, Su F, Briggs J, Liu X, Melman T, Asara JM, ... ... Locasale JW, et al. Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. Cancer Research. 75: 554-65. PMID 25511375 DOI: 10.1158/0008-5472.CAN-14-2268  0.92
2015 Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, ... ... Locasale JW, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. The Journal of Clinical Investigation. 125: 194-207. PMID 25437876 DOI: 10.1172/JCI76012  1
2014 Chen KY, Liu X, Bu P, Lin CS, Rakhilin N, Locasale JW, Shen X. A metabolic signature of colon cancer initiating cells. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2014: 4759-62. PMID 25571056 DOI: 10.1109/EMBC.2014.6944688  0.32
2014 Mehrmohamadi M, Liu X, Shestov AA, Locasale JW. Characterization of the usage of the serine metabolic network in human cancer. Cell Reports. 9: 1507-19. PMID 25456139 DOI: 10.1016/j.celrep.2014.10.026  0.32
2014 Huang L, Kim D, Liu X, Myers CR, Locasale JW. Estimating relative changes of metabolic fluxes. Plos Computational Biology. 10: e1003958. PMID 25412287 DOI: 10.1371/journal.pcbi.1003958  0.32
2014 Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, Kim D, Le A, Yellen G, Albeck JG, Locasale JW. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife. 3. PMID 25009227 DOI: 10.7554/eLife.03342  1
2014 Liu X, Ser Z, Cluntun AA, Mentch SJ, Locasale JW. A strategy for sensitive, large scale quantitative metabolomics. Journal of Visualized Experiments : Jove. PMID 24894601 DOI: 10.3791/51358  1
2014 Dasgupta T, Croll DH, Owen JA, Vander Heiden MG, Locasale JW, Alon U, Cantley LC, Gunawardena J. A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis. The Journal of Biological Chemistry. 289: 13010-25. PMID 24634222 DOI: 10.1074/jbc.M113.546515  1
2014 Sun S, Shi G, Han X, Francisco AB, Ji Y, Mendonça N, Liu X, Locasale JW, Simpson KW, Duhamel GE, Kersten S, Yates JR, Long Q, Qi L. Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proceedings of the National Academy of Sciences of the United States of America. 111: E582-91. PMID 24453213 DOI: 10.1073/pnas.1318114111  1
2014 Liu X, Ser Z, Locasale JW. Development and quantitative evaluation of a high-resolution metabolomics technology. Analytical Chemistry. 86: 2175-84. PMID 24410464 DOI: 10.1021/ac403845u  0.32
2014 Parkhitko AA, Priolo C, Coloff JL, Yun J, Wu JJ, Mizumura K, Xu W, Malinowska IA, Yu J, Kwiatkowski DJ, Locasale JW, Asara JM, Choi AM, Finkel T, Henske EP. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Molecular Cancer Research : McR. 12: 48-57. PMID 24296756 DOI: 10.1158/1541-7786.MCR-13-0258-T  0.32
2013 Shestov AA, Barker B, Gu Z, Locasale JW. Computational approaches for understanding energy metabolism. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 5: 733-50. PMID 23897661 DOI: 10.1002/wsbm.1238  1
2013 Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, Vander Heiden MG, Vitkup D. Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nature Biotechnology. 31: 522-9. PMID 23604282 DOI: 10.1038/nbt.2530  1
2013 Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL. Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Nature Structural & Molecular Biology. 20: 46-52. PMID 23178454 DOI: 10.1038/nsmb.2430  1
2013 Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (New York, N.Y.). 339: 222-6. PMID 23118012 DOI: 10.1126/science.1226603  1
2012 Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 149: 656-70. PMID 22541435 DOI: 10.1016/j.cell.2012.01.058  1
2012 Locasale JW, Melman T, Song S, Yang X, Swanson KD, Cantley LC, Wong ET, Asara JM. Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma. Molecular & Cellular Proteomics : McP. 11: M111.014688. PMID 22240505 DOI: 10.1074/mcp.M111.014688  1
2011 Shyh-Chang N, Zheng Y, Locasale JW, Cantley LC. Human pluripotent stem cells decouple respiration from energy production. The Embo Journal. 30: 4851-2. PMID 22166995 DOI: 10.1038/emboj.2011.436  1
2011 Locasale JW, Cantley LC. Genetic selection for enhanced serine metabolism in cancer development. Cell Cycle (Georgetown, Tex.). 10: 3812-3. PMID 22064516 DOI: 10.4161/cc.10.22.18224  1
2011 Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science (New York, N.Y.). 334: 1278-83. PMID 22052977 DOI: 10.1126/science.1211485  1
2011 Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell. 44: 290-303. PMID 22017875 DOI: 10.1016/j.molcel.2011.08.030  1
2011 Locasale JW, Cantley LC. Metabolic flux and the regulation of mammalian cell growth. Cell Metabolism. 14: 443-51. PMID 21982705 DOI: 10.1016/j.cmet.2011.07.014  1
2011 Mullarky E, Mattaini KR, Vander Heiden MG, Cantley LC, Locasale JW. PHGDH amplification and altered glucose metabolism in human melanoma. Pigment Cell & Melanoma Research. 24: 1112-5. PMID 21981974 DOI: 10.1111/j.1755-148X.2011.00919.x  1
2011 Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, et al. Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell. 146: 607-20. PMID 21854985 DOI: 10.1016/j.cell.2011.06.050  1
2011 Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/ng.890  1
2011 Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC. Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Science Signaling. 4: ra13. PMID 21386094 DOI: 10.1126/scisignal.2001518  1
2010 Locasale JW, Vander Heiden MG, Cantley LC. Rewiring of glycolysis in cancer cell metabolism. Cell Cycle (Georgetown, Tex.). 9: 4253. PMID 21045562 DOI: 10.4161/cc.9.21.13925  1
2010 Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (New York, N.Y.). 329: 1492-9. PMID 20847263 DOI: 10.1126/science.1188015  1
2010 Locasale JW, Cantley LC. Altered metabolism in cancer. Bmc Biology. 8: 88. PMID 20598111 DOI: 10.1186/1741-7007-8-88  1
2009 Locasale JW, Cantley LC, Vander Heiden MG. Cancer's insatiable appetite. Nature Biotechnology. 27: 916-7. PMID 19816448 DOI: 10.1038/nbt1009-916  1
2009 Locasale JW, Napoli AA, Chen S, Berman HM, Lawson CL. Signatures of Protein-DNA Recognition in Free DNA Binding Sites Journal of Molecular Biology. 386: 1054-1065. PMID 19244617 DOI: 10.1016/j.jmb.2009.01.007  1
2008 Locasale JW, Chakraborty AK. Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins. Plos Computational Biology. 4: e1000099. PMID 18584022 DOI: 10.1371/journal.pcbi.1000099  1
2007 Locasale JW, Shaw AS, Chakraborty AK. Scaffold proteins confer diverse regulatory properties to protein kinase cascades. Proceedings of the National Academy of Sciences of the United States of America. 104: 13307-12. PMID 17686969 DOI: 10.1073/pnas.0706311104  1
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