| Year |
Citation |
Score |
| 2023 |
Singh S, Kanzin D, Chavez S, Saavedra-Avila NA, Ng TW, Lukose R, Mayer O, Kim J, Chen B, Chen M, Porcelli SA, Jacobs WR, Tiwari S. Boosting bactericidal immunity of a recombinant strain via zinc-dependent ribosomal proteins. Biorxiv : the Preprint Server For Biology. PMID 38168334 DOI: 10.1101/2023.12.11.571163 |
0.335 |
|
| 2023 |
Koleske BN, Jacobs WR, Bishai WR. The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions. The Journal of Clinical Investigation. 133. PMID 37781921 DOI: 10.1172/JCI173156 |
0.3 |
|
| 2023 |
Sparks IL, Derbyshire KM, Jacobs WR, Morita YS. Mycobacterium smegmatis: The Vanguard of Mycobacterial Research. Journal of Bacteriology. 205: e0033722. PMID 36598232 DOI: 10.1128/jb.00337-22 |
0.379 |
|
| 2022 |
Jacobs WR. A world without tuberculosis: moving from imagination to reality. The Journal of Clinical Investigation. 132. PMID 36106635 DOI: 10.1172/JCI162688 |
0.385 |
|
| 2020 |
Tiwari S, Dutt TS, Chen B, Chen M, Kim J, Dai AZ, Lukose R, Shanley C, Fox A, Karger BR, Porcelli SA, Chan J, Podell BK, Obregon-Henao A, Orme IM, ... Jacobs WR, et al. BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis. Vaccine. PMID 32978002 DOI: 10.1016/j.vaccine.2020.08.004 |
0.344 |
|
| 2020 |
Jain P, Garing S, Verma D, Saranathan R, Clute-Reinig N, Gadwa J, Peterson C, Hermansky G, Astashkina Fernandez A, Asare E, Weisbrod TR, Spencer E, Mulholland CV, Berney M, Bell D, ... ... Jacobs WR, et al. NanoLuciferase reporter mycobacteriophage for sensitive and rapid detection of drug susceptibility. Journal of Bacteriology. PMID 32900827 DOI: 10.1128/Jb.00411-20 |
0.455 |
|
| 2020 |
Burn Aschner C, Loh LN, Galen B, Delwel I, Jangra RK, Garforth SJ, Chandran K, Almo S, Jacobs WR, Ware CF, Herold BC. HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses. Science Immunology. 5. PMID 32817296 DOI: 10.1126/Sciimmunol.Aax2454 |
0.337 |
|
| 2020 |
Vilchèze C, Saranathan R, Weinrick B, Jacobs WR. Characterization of Large Deletion Mutants of Mycobacterium tuberculosis Selected for Isoniazid Resistance. Antimicrobial Agents and Chemotherapy. 64. PMID 32631825 DOI: 10.1128/Aac.00792-20 |
0.46 |
|
| 2020 |
Ng TW, Wirchnianski AS, Wec AZ, Fels JM, Johndrow CT, Saunders KO, Liao HX, Chan J, Jacobs WR, Chandran K, Porcelli SA. Exploiting Pre-Existing CD4 T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses. Journal of Immunology (Baltimore, Md. : 1950). PMID 32513849 DOI: 10.4049/Jimmunol.2000191 |
0.335 |
|
| 2020 |
Ramsey NLM, Visciano M, Hunte R, Loh LN, Aschner CB, Jacobs WR, Herold BC. A single-cycle glycoprotein D deletion viral vaccine candidate, ΔgD-2, elicits polyfunctional antibodies that protect against ocular herpes simplex virus. Journal of Virology. PMID 32295919 DOI: 10.1128/Jvi.00335-20 |
0.322 |
|
| 2020 |
Hingley-Wilson SM, Ma N, Hu Y, Casey R, Bramming A, Curry RJ, Tang HL, Wu H, Butler RE, Jacobs WR, Rocco A, McFadden J. Loss of phenotypic inheritance associated with mutation leads to increased frequency of small, slow persisters in . Proceedings of the National Academy of Sciences of the United States of America. PMID 32029596 DOI: 10.1073/Pnas.1914741117 |
0.342 |
|
| 2019 |
Saranathan R, Levi MH, Wattam AR, Malek A, Asare E, Behin DS, Pan DH, Jacobs WR, Szymczak WA. infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-genome Sequencing. Journal of Clinical Microbiology. PMID 31801839 DOI: 10.1128/Jcm.01591-19 |
0.317 |
|
| 2019 |
Hasenoehrl EJ, Rae Sajorda D, Berney-Meyer L, Johnson S, Tufariello JM, Fuhrer T, Cook GM, Jacobs WR, Berney M. Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection. Nature Communications. 10: 4215. PMID 31527595 DOI: 10.1038/S41467-019-12224-3 |
0.403 |
|
| 2019 |
Chiner-Oms Á, Berney M, Boinett C, González-Candelas F, Young DB, Gagneux S, Jacobs WR, Parkhill J, Cortes T, Comas I. Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex. Nature Communications. 10: 3994. PMID 31488832 DOI: 10.1038/S41467-019-11948-6 |
0.369 |
|
| 2019 |
Kalscheuer R, Palacios A, Anso I, Cifuente J, Anguita J, Jacobs WR, Guerin ME, Prados-Rosales R. The capsule: a cell structure with key implications in pathogenesis. The Biochemical Journal. 476: 1995-2016. PMID 31320388 DOI: 10.1042/Bcj20190324 |
0.365 |
|
| 2019 |
Tiwari S, Casey R, Goulding CW, Hingley-Wilson S, Jacobs WR. Infect and Inject: How Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1. Microbiology Spectrum. 7. PMID 31172908 DOI: 10.1128/Microbiolspec.Bai-0024-2019 |
0.33 |
|
| 2019 |
O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, Wolf A, Uccellini L, Karim F, de Oliveira T, Mathema B, Jacobs WR, Pym A. Erratum for O'Donnell et al., "Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing". Antimicrobial Agents and Chemotherapy. 63. PMID 31126923 DOI: 10.1128/Aac.00764-19 |
0.314 |
|
| 2019 |
Porcelli SA, Jacobs WR. Exacting Edward Jenner's revenge: The quest for a new tuberculosis vaccine. Science Translational Medicine. 11. PMID 31043569 DOI: 10.1126/Scitranslmed.Aax4219 |
0.375 |
|
| 2019 |
Shen L, Frencher J, Huang D, Wang W, Yang E, Chen CY, Zhang Z, Wang R, Qaqish A, Larsen MH, Shen H, Porcelli SA, Jacobs WR, Chen ZW. Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America. PMID 30850538 DOI: 10.1073/Pnas.1811380116 |
0.399 |
|
| 2019 |
Vilchèze C, Jacobs WR. The Isoniazid Paradigm of Killing, Resistance, and Persistence in Mycobacterium tuberculosis. Journal of Molecular Biology. 431: 3450-3461. PMID 30797860 DOI: 10.1016/J.Jmb.2019.02.016 |
0.485 |
|
| 2019 |
O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, Wolf A, Uccellini L, Karim F, D'Olivera T, Mathema B, Jacobs WR, Pym A. Early detection of emergent extensively drug resistant tuberculosis (XDR-TB) by flow cytometry-based phenotyping and whole genome sequencing. Antimicrobial Agents and Chemotherapy. PMID 30670422 DOI: 10.1128/Aac.01834-18 |
0.404 |
|
| 2018 |
Johndrow CT, Goldberg MF, Johnson AJ, Ng TW, Kunnath-Velayudhan S, Lauvau G, Kaplan DH, Gossel GH, Kadolsky UD, Yates AJ, Chan J, Jacobs WR, Porcelli SA. Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2 Monocytes. Journal of Immunology (Baltimore, Md. : 1950). PMID 30455402 DOI: 10.4049/Jimmunol.1801185 |
0.326 |
|
| 2018 |
Bhatt K, Machado H, Osório NS, Sousa J, Cardoso F, Magalhães C, Chen B, Chen M, Kim J, Singh A, Ferreira CM, Castro AG, Torrado E, Jacobs WR, Bhatt A, et al. A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis. Msphere. 3. PMID 30381350 DOI: 10.1128/mSphere.00352-18 |
0.317 |
|
| 2018 |
Tiwari S, van Tonder AJ, Vilchèze C, Mendes V, Thomas SE, Malek A, Chen B, Chen M, Kim J, Blundell TL, Parkhill J, Weinrick B, Berney M, Jacobs WR. Arginine-deprivation-induced oxidative damage sterilizes . Proceedings of the National Academy of Sciences of the United States of America. PMID 30143580 DOI: 10.1073/Pnas.1808874115 |
0.311 |
|
| 2018 |
Kennedy SC, Johnson AJ, Bharrhan S, Lindestam Arlehamn CS, Xu J, Garforth SJ, Chan J, Jacobs WR, Sette A, Almo SC, Porcelli SA. Identification of mycobacterial ribosomal proteins as targets for CD4 T cells that enhance protective immunity in tuberculosis. Infection and Immunity. PMID 29891545 DOI: 10.1128/Iai.00009-18 |
0.361 |
|
| 2018 |
Vilchèze C, Copeland J, Keiser TL, Weisbrod T, Washington J, Jain P, Malek A, Weinrick B, Jacobs WR. Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy. Mbio. 9. PMID 29844114 DOI: 10.1128/Mbio.00938-18 |
0.41 |
|
| 2018 |
Harbut MB, Liu R, Yang B, Yano T, Vilcheze C, Lockner J, Guo H, Franzblau SG, Petrassi M, Jacobs WR, Rubin H, Chatterjee AK, Wang F. Small molecules targeting Mycobacterium tuberculosis type II NADH dehydrogenase with antimycobacterial activity. Angewandte Chemie (International Ed. in English). PMID 29388301 DOI: 10.1002/Anie.201800260 |
0.385 |
|
| 2018 |
Vilchèze C, Weinrick B, Leung LW, Jacobs WR. Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence. Proceedings of the National Academy of Sciences of the United States of America. PMID 29382761 DOI: 10.1073/Pnas.1721545115 |
0.463 |
|
| 2018 |
Vilchèze C, Kim J, Jacobs WR. Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in mice. Antimicrobial Agents and Chemotherapy. PMID 29298757 DOI: 10.1128/Aac.02165-17 |
0.424 |
|
| 2018 |
Jacobs WR, Boshoff H. Decision letter: The genetic requirements of fatty acid import by Mycobacterium tuberculosis within macrophages Elife. DOI: 10.7554/Elife.43621.014 |
0.354 |
|
| 2018 |
Bald D, Jacobs WR. Decision letter: Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages Elife. DOI: 10.7554/Elife.39169.017 |
0.347 |
|
| 2017 |
Burn C, Ramsey N, Garforth SJ, Almo S, Jacobs WR, Herold BC. An HSV-2 single-cycle candidate vaccine deleted in glycoprotein D, ΔgD-2, protects male mice from lethal skin challenge with clinical isolates of HSV-1 and HSV-2. The Journal of Infectious Diseases. PMID 29216362 DOI: 10.1093/Infdis/Jix628 |
0.309 |
|
| 2017 |
Retamal-Díaz A, Weiss KA, Tognarelli EI, Freire M, Bueno SM, Herold BC, Jacobs WR, González PA. US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation. Frontiers in Immunology. 8: 1523. PMID 29176979 DOI: 10.3389/Fimmu.2017.01523 |
0.328 |
|
| 2017 |
Liu R, Lyu X, Hsu MH, Vilcheze C, Franzblau SG, Jacobs WR, Besra GS, Johnson EF, Fütterer K, Wang F. Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes. Angewandte Chemie (International Ed. in English). PMID 28815830 DOI: 10.1002/Anie.201707324 |
0.4 |
|
| 2017 |
Glass LN, Swapna G, Chavadi SS, Tufariello JM, Mi K, Drumm JE, Lam TT, Zhu G, Zhan C, Vilchéze C, Arcos J, Chen Y, Bi L, Mehta S, Porcelli SA, ... ... Jacobs WR, et al. Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (APC) transporter Rv1747 to regulate mycobacterial growth. Plos Pathogens. 13: e1006515. PMID 28753640 DOI: 10.1371/Journal.Ppat.1006515 |
0.39 |
|
| 2017 |
Yang Y, Thomas J, Li Y, Vilchèze C, Derbyshire KM, Jacobs WR, Ojha AK. Defining a temporal order of genetic requirements for development of mycobacterial biofilms. Molecular Microbiology. PMID 28628249 DOI: 10.1111/Mmi.13734 |
0.326 |
|
| 2017 |
Saito K, Warrier T, Somersan-Karakaya S, Kaminski L, Mi J, Jiang X, Park S, Shigyo K, Gold B, Roberts J, Weber E, Jacobs WR, Nathan CF. Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations. Proceedings of the National Academy of Sciences of the United States of America. PMID 28559332 DOI: 10.1073/Pnas.1705385114 |
0.437 |
|
| 2017 |
Qaqish A, Huang D, Chen CY, Zhang Z, Wang R, Li S, Yang E, Lu Y, Larsen MH, Jacobs WR, Qian L, Frencher J, Shen L, Chen ZW. Adoptive Transfer of Phosphoantigen-Specific γδ T Cell Subset Attenuates Mycobacterium tuberculosis Infection in Nonhuman Primates. Journal of Immunology (Baltimore, Md. : 1950). PMID 28526681 DOI: 10.4049/Jimmunol.1602019 |
0.432 |
|
| 2017 |
Vilchèze C, Hartman T, Weinrick B, Jain P, Weisbrod TR, Leung LW, Freundlich JS, Jacobs WR. Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396391 DOI: 10.1073/Pnas.1704376114 |
0.381 |
|
| 2017 |
Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR, Ciulli A, et al. Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach. British Journal of Pharmacology. PMID 28380256 DOI: 10.1111/Bph.13810 |
0.446 |
|
| 2017 |
Kerantzas CA, Jacobs WR. Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application. Mbio. 8. PMID 28292983 DOI: 10.1128/Mbio.01586-16 |
0.368 |
|
| 2017 |
Johnson AJ, Kennedy SC, Lindestam Arlehamn CS, Goldberg MF, Saini NK, Xu J, Paul S, Hegde SS, Blanchard JS, Chan J, Jacobs WR, Sette A, Porcelli SA. Identification of mycobacterial RplJ/L10 and RpsA/S1 proteins as novel targets for CD4+ T cells. Infection and Immunity. PMID 28115505 DOI: 10.1128/Iai.01023-16 |
0.404 |
|
| 2016 |
Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R. Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice. Plos Pathogens. 12: e1006043. PMID 27936238 DOI: 10.1371/Journal.Ppat.1006043 |
0.47 |
|
| 2016 |
Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs WR, Philips JA. Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4(+) T-cell activation. Nature Microbiology. 2: 16232. PMID 27918526 DOI: 10.1038/Nmicrobiol.2016.232 |
0.37 |
|
| 2016 |
Maggioli MF, Palmer MV, Thacker TC, Vordermeier HM, McGill JL, Whelan AO, Larsen MH, Jacobs WR, Waters WR. Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination. Frontiers in Immunology. 7: 421. PMID 27799930 DOI: 10.3389/Fimmu.2016.00421 |
0.384 |
|
| 2016 |
Jain P, Weinrick BC, Kalivoda EJ, Yang H, Munsamy V, Vilcheze C, Weisbrod TR, Larsen MH, O'Donnell MR, Pym A, Jacobs WR. Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum. Mbio. 7. PMID 27795387 DOI: 10.1128/Mbio.01023-16 |
0.469 |
|
| 2016 |
Mayer O, Jain P, Weisbrod T, Biro D, Ho L, Jacobs-Sera D, Hatfull GF, Jacobs WR. Fluorescent reporter DS6A mycobacteriophages reveal unique variations in infectability and phage production in mycobacteria. Journal of Bacteriology. PMID 27672191 DOI: 10.1128/Jb.00592-16 |
0.423 |
|
| 2016 |
Jensen K, Dela Pena-Ponce MG, Piatak M, Shoemaker R, Oswald K, Jacobs WR, Fennelly G, Lucero C, Mollan KR, Hudgens MG, Amedee A, Kozlowski PA, Estes JD, Lifson JD, Van Rompay KK, et al. Balancing trained immunity with persistent immune activation and the risk of SIV infection in infant macaques vaccinated with attenuated Mycobacterium tuberculosis or BCG vaccines. Clinical and Vaccine Immunology : Cvi. PMID 27655885 DOI: 10.1128/Cvi.00360-16 |
0.352 |
|
| 2016 |
Foreman TW, Mehra S, LoBato DN, Malek A, Alvarez X, Golden NA, Bucşan AN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Roy CJ, Blanchard J, Kuroda MJ, Lackner AA, Chan J, ... ... Jacobs WR, et al. CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601645 DOI: 10.1073/Pnas.1611987113 |
0.397 |
|
| 2016 |
Vergnolle O, Xu H, Tufariello JM, Favrot L, Malek AA, Jacobs WR, Blanchard JS. Post-Translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis. The Journal of Biological Chemistry. PMID 27566542 DOI: 10.1074/Jbc.M116.744532 |
0.358 |
|
| 2016 |
Saini NK, Baena A, Ng TW, Venkataswamy MM, Kennedy SC, Kunnath-Velayudhan S, Carreño LJ, Xu J, Chan J, Larsen MH, Jacobs WR, Porcelli SA. Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47. Nature Microbiology. 1: 16133. PMID 27562263 DOI: 10.1038/Nmicrobiol.2016.133 |
0.47 |
|
| 2016 |
Petro CD, Weinrick B, Khajoueinejad N, Burn C, Sellers R, Jacobs WR, Herold BC. HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates. Jci Insight. 1. PMID 27536733 DOI: 10.1172/Jci.Insight.88529 |
0.329 |
|
| 2016 |
Halloum I, Carrère-Kremer S, Blaise M, Viljoen A, Bernut A, Le Moigne V, Vilchèze C, Guérardel Y, Lutfalla G, Herrmann JL, Jacobs WR, Kremer L. Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent. Proceedings of the National Academy of Sciences of the United States of America. PMID 27385830 DOI: 10.1073/Pnas.1605477113 |
0.331 |
|
| 2016 |
Yu X, Gu Y, Jiang G, Ma Y, Zhao L, Sun Z, Jain P, O'Donnell M, Larsen M, Jacobs WR, Huang H. Evaluation of a High-Intensity Green Fluorescent Protein Fluorophage Method for Drug- Resistance Diagnosis in Tuberculosis for Isoniazid, Rifampin, and Streptomycin. Frontiers in Microbiology. 7: 922. PMID 27379052 DOI: 10.3389/Fmicb.2016.00922 |
0.357 |
|
| 2016 |
Jensen K, Nabi R, Van Rompay KK, Robichaux S, Lifson JD, Piatak M, Jacobs WR, Fennelly G, Canfield D, Mollan KR, Hudgens MG, Larsen MH, Amedee AM, Kozlowski PA, De Paris K. Vaccine-elicited mucosal and systemic antibody responses are associated with reduced simian immunodeficiency viremia in infant rhesus macaques. Journal of Virology. PMID 27252535 DOI: 10.1128/Jvi.00481-16 |
0.336 |
|
| 2016 |
Olsen A, Chen Y, Ji Q, Zhu G, De Silva AD, Vilchèze C, Weisbrod T, Li W, Xu J, Larsen M, Zhang J, Porcelli SA, Jacobs WR, Chan J. Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines. Mbio. 7. PMID 27247233 DOI: 10.1128/Mbio.01023-15 |
0.48 |
|
| 2016 |
Prados-Rosales R, Carreño LJ, Weinrick B, Batista-Gonzalez A, Glatman-Freedman A, Xu J, Chan J, Jacobs WR, Porcelli SA, Casadevall A. The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination Against Mycobacterium tuberculosis. The Journal of Infectious Diseases. PMID 27234419 DOI: 10.1093/Infdis/Jiw153 |
0.418 |
|
| 2016 |
Noy T, Vergnolle O, Hartman TE, Rhee KY, Jacobs WR, Berney M, Blanchard JS. Central Role of Pyruvate Kinase in Carbon Co-Catabolism of Mycobacterium tuberculosis. The Journal of Biological Chemistry. PMID 26858255 DOI: 10.1074/Jbc.M115.707430 |
0.303 |
|
| 2016 |
Wong KW, Jacobs WR. Postprimary Tuberculosis and Macrophage Necrosis: Is There a Big ConNECtion? Mbio. 7. PMID 26758178 DOI: 10.1128/Mbio.01589-15 |
0.418 |
|
| 2016 |
Tufariello JM, Chapman JR, Kerantzas CA, Wong KW, Vilchèze C, Jones CM, Cole LE, Tinaztepe E, Thompson V, Fenyö D, Niederweis M, Ueberheide B, Philips JA, Jacobs WR. Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence. Proceedings of the National Academy of Sciences of the United States of America. PMID 26729876 DOI: 10.1073/Pnas.1523321113 |
0.32 |
|
| 2015 |
Tufariello JM, Kerantzas CA, Vilchèze C, Calder RB, Nordberg EK, Fischer JA, Hartman TE, Yang E, Driscoll T, Cole LE, Sebra R, Maqbool SB, Wattam AR, Jacobs WR. The Complete Genome Sequence of the Emerging Pathogen Mycobacterium haemophilum Explains Its Unique Culture Requirements. Mbio. 6. PMID 26578674 DOI: 10.1128/Mbio.01313-15 |
0.401 |
|
| 2015 |
Packiam M, Weinrick B, Jacobs WR, Maurelli AT. Structural characterization of muropeptides from Chlamydia trachomatis peptidoglycan by mass spectrometry resolves "chlamydial anomaly". Proceedings of the National Academy of Sciences of the United States of America. 112: 11660-5. PMID 26290580 DOI: 10.1073/Pnas.1514026112 |
0.325 |
|
| 2015 |
Li SG, Vilchèze C, Chakraborty S, Wang X, Kim H, Anisetti M, Ekins S, Rhee KY, Jacobs WR, Freundlich JS. Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights. Tetrahedron Letters. 56: 3246-3250. PMID 26257441 DOI: 10.1016/J.Tetlet.2015.02.129 |
0.345 |
|
| 2015 |
Vilchèze C, Leung LW, Bittman R, Jacobs WR. Synthesis and biological activity of alkynoic acids derivatives against mycobacteria. Chemistry and Physics of Lipids. PMID 26256431 DOI: 10.1016/J.Chemphyslip.2015.08.001 |
0.332 |
|
| 2015 |
Berney M, Berney-Meyer L, Wong KW, Chen B, Chen M, Kim J, Wang J, Harris D, Parkhill J, Chan J, Wang F, Jacobs WR. Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26221021 DOI: 10.1073/Pnas.1513033112 |
0.46 |
|
| 2015 |
O'Donnell MR, Pym A, Jain P, Munsamy V, Wolf A, Karim F, Jacobs WR, Larsen MH. A Novel Reporter Phage To Detect Tuberculosis and Rifampin Resistance in a High-HIV-Burden Population. Journal of Clinical Microbiology. 53: 2188-94. PMID 25926493 DOI: 10.1128/Jcm.03530-14 |
0.451 |
|
| 2015 |
Hart BE, Asrican R, Lim SY, Sixsmith JD, Lukose R, Souther SJ, Rayasam SD, Saelens JW, Chen CJ, Seay SA, Berney-Meyer L, Magtanong L, Vermeul K, Pajanirassa P, Jimenez AE, ... ... Jacobs WR, et al. Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors. Clinical and Vaccine Immunology : Cvi. 22: 726-41. PMID 25924766 DOI: 10.1128/Cvi.00075-15 |
0.368 |
|
| 2015 |
Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR, Schultz PG, Wang F. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 112: 4453-8. PMID 25831516 DOI: 10.1073/Pnas.1504022112 |
0.393 |
|
| 2015 |
Ojha AK, Jacobs WR, Hatfull GF. Genetic dissection of mycobacterial biofilms. Methods in Molecular Biology (Clifton, N.J.). 1285: 215-26. PMID 25779318 DOI: 10.1007/978-1-4939-2450-9_12 |
0.323 |
|
| 2015 |
Petro C, González PA, Cheshenko N, Jandl T, Khajoueinejad N, Bénard A, Sengupta M, Herold BC, Jacobs WR. Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease. Elife. 4. PMID 25756612 DOI: 10.7554/Elife.06054 |
0.311 |
|
| 2015 |
Chandrabos C, M'Homa Soudja S, Weinrick B, Gros M, Frangaj A, Rahmoun M, Jacobs WR, Lauvau G. The p60 and NamA autolysins from Listeria monocytogenes contribute to host colonization and induction of protective memory. Cellular Microbiology. 17: 147-63. PMID 25225110 DOI: 10.1111/Cmi.12362 |
0.324 |
|
| 2014 |
Vilchèze C, Jacobs WR. Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities. Microbiology Spectrum. 2: MGM2-0014-2013. PMID 26104204 DOI: 10.1128/microbiolspec.MGM2-0014-2013 |
0.308 |
|
| 2014 |
Pope WH, Jacobs-Sera D, Russell DA, Rubin DH, Kajee A, Msibi ZN, Larsen MH, Jacobs WR, Lawrence JG, Hendrix RW, Hatfull GF. Genomics and proteomics of mycobacteriophage patience, an accidental tourist in the Mycobacterium neighborhood. Mbio. 5: e02145. PMID 25467442 DOI: 10.1128/Mbio.02145-14 |
0.34 |
|
| 2014 |
Hartman T, Weinrick B, Vilchèze C, Berney M, Tufariello J, Cook GM, Jacobs WR. Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis. Plos Pathogens. 10: e1004510. PMID 25412183 DOI: 10.1371/Journal.Ppat.1004510 |
0.354 |
|
| 2014 |
Panas MW, Sixsmith JD, White K, Korioth-Schmitz B, Shields ST, Moy BT, Lee S, Schmitz JE, Jacobs WR, Porcelli SA, Haynes BF, Letvin NL, Gillard GO. Gene deletions in Mycobacterium bovis BCG stimulate increased CD8+ T cell responses. Infection and Immunity. 82: 5317-26. PMID 25287928 DOI: 10.1128/Iai.02100-14 |
0.37 |
|
| 2014 |
Prados-Rosales R, Carreño LJ, Batista-Gonzalez A, Baena A, Venkataswamy MM, Xu J, Yu X, Wallstrom G, Magee DM, LaBaer J, Achkar JM, Jacobs WR, Chan J, Porcelli SA, Casadevall A. Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis. Mbio. 5: e01921-14. PMID 25271291 DOI: 10.1128/Mbio.01921-14 |
0.436 |
|
| 2014 |
Venkataswamy MM, Ng TW, Kharkwal SS, Carreño LJ, Johnson AJ, Kunnath-Velayudhan S, Liu Z, Bittman R, Jervis PJ, Cox LR, Besra GS, Wen X, Yuan W, Tsuji M, Li X, ... ... Jacobs WR, et al. Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. Plos One. 9: e108383. PMID 25255287 DOI: 10.1371/Journal.Pone.0108383 |
0.337 |
|
| 2014 |
Panas MW, Jain P, Yang H, Mitra S, Biswas D, Wattam AR, Letvin NL, Jacobs WR. Noncanonical SMC protein in Mycobacterium smegmatis restricts maintenance of Mycobacterium fortuitum plasmids. Proceedings of the National Academy of Sciences of the United States of America. 111: 13264-71. PMID 25197070 DOI: 10.1073/Pnas.1414207111 |
0.429 |
|
| 2014 |
Stec J, Vilchèze C, Lun S, Perryman AL, Wang X, Freundlich JS, Bishai W, Jacobs WR, Kozikowski AP. Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis. Chemmedchem. 9: 2528-37. PMID 25165007 DOI: 10.1002/Cmdc.201402255 |
0.362 |
|
| 2014 |
Pecsi I, Hards K, Ekanayaka N, Berney M, Hartman T, Jacobs WR, Cook GM. Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia. Mbio. 5. PMID 25118234 DOI: 10.1128/Mbio.01093-14 |
0.301 |
|
| 2014 |
Sixsmith JD, Panas MW, Lee S, Gillard GO, White K, Lifton MA, Balachandran H, Mach L, Miller JP, Lavine C, DeMarco CT, Tomaras GD, Gee C, Porcelli SA, Larsen MH, ... ... Jacobs WR, et al. Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques. Clinical and Vaccine Immunology : Cvi. 21: 1385-95. PMID 25080550 DOI: 10.1128/Cvi.00324-14 |
0.363 |
|
| 2014 |
Berney M, Hartman TE, Jacobs WR. A Mycobacterium tuberculosis cytochrome bd oxidase mutant is hypersensitive to bedaquiline. Mbio. 5: e01275-14. PMID 25028424 DOI: 10.1128/Mbio.01275-14 |
0.446 |
|
| 2014 |
Jain P, Hsu T, Arai M, Biermann K, Thaler DS, Nguyen A, González PA, Tufariello JM, Kriakov J, Chen B, Larsen MH, Jacobs WR. Specialized transduction designed for precise high-throughput unmarked deletions in Mycobacterium tuberculosis. Mbio. 5: e01245-14. PMID 24895308 DOI: 10.1128/Mbio.01245-14 |
0.442 |
|
| 2014 |
Bartek IL, Woolhiser LK, Baughn AD, Basaraba RJ, Jacobs WR, Lenaerts AJ, Voskuil MI. Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence. Mbio. 5: e01106-14. PMID 24895305 DOI: 10.1128/Mbio.01106-14 |
0.419 |
|
| 2014 |
Tufariello JM, Malek AA, Vilchèze C, Cole LE, Ratner HK, González PA, Jain P, Hatfull GF, Larsen MH, Jacobs WR. Enhanced specialized transduction using recombineering in Mycobacterium tuberculosis. Mbio. 5: e01179-14. PMID 24865558 DOI: 10.1128/Mbio.01179-14 |
0.491 |
|
| 2014 |
Vilchèze C, Molle V, Carrère-Kremer S, Leiba J, Mourey L, Shenai S, Baronian G, Tufariello J, Hartman T, Veyron-Churlet R, Trivelli X, Tiwari S, Weinrick B, Alland D, Guérardel Y, ... Jacobs WR, et al. Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis. Plos Pathogens. 10: e1004115. PMID 24809459 DOI: 10.1371/Journal.Ppat.1004115 |
0.396 |
|
| 2014 |
Smith KL, Saini D, Bardarov S, Larsen M, Frothingham R, Gandhi NR, Jacobs WR, Sturm AW, Lee S. Reduced virulence of an extensively drug-resistant outbreak strain of Mycobacterium tuberculosis in a murine model. Plos One. 9: e94953. PMID 24733050 DOI: 10.1371/Journal.Pone.0094953 |
0.407 |
|
| 2014 |
Ramón-GarcÃa S, Vilchèze C, Lim LE, Ng C, Jacobs WR, Thompson CJ. Measurements of the in vitro anti-mycobacterial activity of ivermectin are method-dependent--authors' response. The Journal of Antimicrobial Chemotherapy. 69: 1725-6. PMID 24722835 DOI: 10.1093/Jac/Dku117 |
0.366 |
|
| 2014 |
Hingley-Wilson SM, Connell D, Pollock K, Hsu T, Tchilian E, Sykes A, Grass L, Potiphar L, Bremang S, Kon OM, Jacobs WR, Lalvani A. ESX1-dependent fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in humans. Tuberculosis (Edinburgh, Scotland). 94: 262-70. PMID 24631198 DOI: 10.1016/J.Tube.2014.01.004 |
0.447 |
|
| 2014 |
Cortesia C, Vilchèze C, Bernut A, Contreras W, Gómez K, de Waard J, Jacobs WR, Kremer L, Takiff H. Acetic Acid, the active component of vinegar, is an effective tuberculocidal disinfectant. Mbio. 5: e00013-14. PMID 24570366 DOI: 10.1128/Mbio.00013-14 |
0.434 |
|
| 2014 |
Ramón-GarcÃa S, Vilchèze C, Lim LE, Ng C, Jacobs WR, Thompson CJ. Measurements of the in vitro anti-mycobacterial activity of ivermectin are method-dependent. The Journal of Antimicrobial Chemotherapy. 69: 1723-4. PMID 24569629 DOI: 10.1093/Jac/Dku037 |
0.425 |
|
| 2014 |
Prados-Rosales R, Weinrick BC, Piqué DG, Jacobs WR, Casadevall A, Rodriguez GM. Role for Mycobacterium tuberculosis membrane vesicles in iron acquisition. Journal of Bacteriology. 196: 1250-6. PMID 24415729 DOI: 10.1128/Jb.01090-13 |
0.38 |
|
| 2014 |
Wong KW, Jacobs WR. Reply to Wallis. The Journal of Infectious Diseases. 209: 628-9. PMID 24133189 DOI: 10.1093/Infdis/Jit556 |
0.432 |
|
| 2013 |
Jensen K, Pena MG, Wilson RL, Ranganathan UD, Jacobs WR, Fennelly G, Larsen M, Van Rompay KK, Kozlowski PA, Abel K. A neonatal oral Mycobacterium tuberculosis-SIV prime / intramuscular MVA-SIV boost combination vaccine induces both SIV and Mtb-specific immune responses in infant macaques. Trials in Vaccinology. 2: 53-63. PMID 24454591 DOI: 10.1016/J.Trivac.2013.09.005 |
0.376 |
|
| 2013 |
Junqueira-Kipnis AP, de Oliveira FM, Trentini MM, Tiwari S, Chen B, Resende DP, Silva BD, Chen M, Tesfa L, Jacobs WR, Kipnis A. Prime-boost with Mycobacterium smegmatis recombinant vaccine improves protection in mice infected with Mycobacterium tuberculosis. Plos One. 8: e78639. PMID 24250805 DOI: 10.1371/Journal.Pone.0078639 |
0.445 |
|
| 2013 |
Chapman R, Stutz H, Jacobs W, Shephard E, Williamson AL. Priming with recombinant auxotrophic BCG expressing HIV-1 Gag, RT and Gp120 and boosting with recombinant MVA induces a robust T cell response in mice. Plos One. 8: e71601. PMID 23977084 DOI: 10.1371/Journal.Pone.0071601 |
0.324 |
|
| 2013 |
Chen CY, Yao S, Huang D, Wei H, Sicard H, Zeng G, Jomaa H, Larsen MH, Jacobs WR, Wang R, Letvin N, Shen Y, Qiu L, Shen L, Chen ZW. Phosphoantigen/IL2 expansion and differentiation of Vγ2Vδ2 T cells increase resistance to tuberculosis in nonhuman primates. Plos Pathogens. 9: e1003501. PMID 23966854 DOI: 10.1371/Journal.Ppat.1003501 |
0.391 |
|
| 2013 |
Kozakiewicz L, Chen Y, Xu J, Wang Y, Dunussi-Joannopoulos K, Ou Q, Flynn JL, Porcelli SA, Jacobs WR, Chan J. B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response. Plos Pathogens. 9: e1003472. PMID 23853593 DOI: 10.1371/Journal.Ppat.1003472 |
0.433 |
|
| 2013 |
Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, ... ... Jacobs WR, et al. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 110: E2510-7. PMID 23776209 DOI: 10.1073/Pnas.1309171110 |
0.428 |
|
| 2013 |
Wilson R, Kumar P, Parashar V, Vilchèze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, Shenai S, Colangeli R, Jacobs WR, Neiditch MB, Kremer L, et al. Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. Nature Chemical Biology. 9: 499-506. PMID 23770708 DOI: 10.1038/Nchembio.1277 |
0.464 |
|
| 2013 |
Vilchèze C, Hartman T, Weinrick B, Jacobs WR. Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction. Nature Communications. 4: 1881. PMID 23695675 DOI: 10.1038/Ncomms2898 |
0.411 |
|
| 2013 |
Sambandan D, Dao DN, Weinrick BC, Vilchèze C, Gurcha SS, Ojha A, Kremer L, Besra GS, Hatfull GF, Jacobs WR. Keto-mycolic acid-dependent pellicle formation confers tolerance to drug-sensitive Mycobacterium tuberculosis. Mbio. 4: e00222-13. PMID 23653446 DOI: 10.1128/Mbio.00222-13 |
0.492 |
|
| 2013 |
Ly D, Kasmar AG, Cheng TY, de Jong A, Huang S, Roy S, Bhatt A, van Summeren RP, Altman JD, Jacobs WR, Adams EJ, Minnaard AJ, Porcelli SA, Moody DB. CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens. The Journal of Experimental Medicine. 210: 729-41. PMID 23530121 DOI: 10.1084/Jem.20120624 |
0.318 |
|
| 2013 |
Miallau L, Jain P, Arbing MA, Cascio D, Phan T, Ahn CJ, Chan S, Chernishof I, Maxson M, Chiang J, Jacobs WR, Eisenberg DS. Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes. Structure (London, England : 1993). 21: 627-37. PMID 23523424 DOI: 10.1016/J.Str.2013.02.008 |
0.444 |
|
| 2013 |
Chege GK, Burgers WA, Stutz H, Meyers AE, Chapman R, Kiravu A, Bunjun R, Shephard EG, Jacobs WR, Rybicki EP, Williamson AL. Robust immunity to an auxotrophic Mycobacterium bovis BCG-VLP prime-boost HIV vaccine candidate in a nonhuman primate model. Journal of Virology. 87: 5151-60. PMID 23449790 DOI: 10.1128/Jvi.03178-12 |
0.324 |
|
| 2013 |
Lim LE, Vilchèze C, Ng C, Jacobs WR, Ramón-GarcÃa S, Thompson CJ. Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains. Antimicrobial Agents and Chemotherapy. 57: 1040-6. PMID 23165468 DOI: 10.1128/Aac.01696-12 |
0.402 |
|
| 2013 |
Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, ... ... Jacobs WR, et al. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis (vol 110, pg E2510, 2013) Proceedings of the National Academy of Sciences of the United States of America. 110: 15848-15848. DOI: 10.1073/Pnas.1315914110 |
0.345 |
|
| 2013 |
Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, ... ... Jacobs WR, et al. Erratum: Identification of a small molecule with activity against drug-resistant and persistent tuberculosis (Proceedings of the National Academy of Sciences of the United States of America (2013) 27:110 (E2510-E2517)) Proceedings of the National Academy of Sciences of the United States of America. 110. DOI: 10.1073/Pnas.1314629110 |
0.337 |
|
| 2012 |
Vilchèze C, Jacobs WR. The combination of sulfamethoxazole, trimethoprim, and isoniazid or rifampin is bactericidal and prevents the emergence of drug resistance in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 56: 5142-8. PMID 22825115 DOI: 10.1128/Aac.00832-12 |
0.466 |
|
| 2012 |
Taylor N, Bahunde F, Thompson A, Yu JS, Jacobs WR, Letvin NL, Haynes BF, Lee S. Enhanced priming of adaptive immunity by Mycobacterium smegmatis mutants with high-level protein secretion. Clinical and Vaccine Immunology : Cvi. 19: 1416-25. PMID 22787192 DOI: 10.1128/Cvi.00131-12 |
0.426 |
|
| 2012 |
Jensen K, Ranganathan UD, Van Rompay KK, Canfield DR, Khan I, Ravindran R, Luciw PA, Jacobs WR, Fennelly G, Larsen MH, Abel K. A recombinant attenuated Mycobacterium tuberculosis vaccine strain is safe in immunosuppressed simian immunodeficiency virus-infected infant macaques. Clinical and Vaccine Immunology : Cvi. 19: 1170-81. PMID 22695156 DOI: 10.1128/Cvi.00184-12 |
0.434 |
|
| 2012 |
Kolibab K, Derrick SC, Jacobs WR, Morris SL. Characterization of an intracellular ATP assay for evaluating the viability of live attenuated mycobacterial vaccine preparations. Journal of Microbiological Methods. 90: 245-9. PMID 22652432 DOI: 10.1016/J.Mimet.2012.05.015 |
0.342 |
|
| 2012 |
Yamada H, Bhatt A, Danev R, Fujiwara N, Maeda S, Mitarai S, Chikamatsu K, Aono A, Nitta K, Jacobs WR, Nagayama K. Non-acid-fastness in Mycobacterium tuberculosis ΔkasB mutant correlates with the cell envelope electron density. Tuberculosis (Edinburgh, Scotland). 92: 351-7. PMID 22516756 DOI: 10.1016/J.Tube.2012.02.006 |
0.333 |
|
| 2012 |
Chapman R, Shephard E, Stutz H, Douglass N, Sambandamurthy V, Garcia I, Ryffel B, Jacobs W, Williamson AL. Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. Plos One. 7: e32769. PMID 22479338 DOI: 10.1371/Journal.Pone.0032769 |
0.373 |
|
| 2012 |
Derrick SC, Dao D, Yang A, Kolibab K, Jacobs WR, Morris SL. Formulation of a mmaA4 gene deletion mutant of Mycobacterium bovis BCG in cationic liposomes significantly enhances protection against tuberculosis. Plos One. 7: e32959. PMID 22442674 DOI: 10.1371/Journal.Pone.0032959 |
0.401 |
|
| 2012 |
Goldberg DE, Siliciano RF, Jacobs WR. Outwitting evolution: fighting drug-resistant TB, malaria, and HIV. Cell. 148: 1271-83. PMID 22424234 DOI: 10.1016/J.Cell.2012.02.021 |
0.35 |
|
| 2012 |
Jain P, Hartman TE, Eisenberg N, O'Donnell MR, Kriakov J, Govender K, Makume M, Thaler DS, Hatfull GF, Sturm AW, Larsen MH, Moodley P, Jacobs WR. φ(2)GFP10, a high-intensity fluorophage, enables detection and rapid drug susceptibility testing of Mycobacterium tuberculosis directly from sputum samples. Journal of Clinical Microbiology. 50: 1362-9. PMID 22278833 DOI: 10.1128/Jcm.06192-11 |
0.439 |
|
| 2012 |
Venkataswamy MM, Goldberg MF, Baena A, Chan J, Jacobs WR, Porcelli SA. In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCG. Vaccine. 30: 1038-49. PMID 22189700 DOI: 10.1016/J.Vaccine.2011.12.044 |
0.352 |
|
| 2012 |
Bourai N, Jacobs WR, Narayanan S. Deletion and overexpression studies on DacB2, a putative low molecular mass penicillin binding protein from Mycobacterium tuberculosis H(37)Rv. Microbial Pathogenesis. 52: 109-16. PMID 22138550 DOI: 10.1016/J.Micpath.2011.11.003 |
0.45 |
|
| 2012 |
Ranganathan UK, Larsen M, Abel K, Jacobs W, Fennelly G. Recombinant attenuated M.tuberculosis-SIVgag(rAMtb-gag) vaccination primes for SIV-specific CD8 T cell response that are boosted by Ad5-SIVgag in mice Retrovirology. 9: 263. DOI: 10.1186/1742-4690-9-S2-P263 |
0.389 |
|
| 2011 |
Chen B, Weisbrod TR, Hsu T, Sambandamurthy V, Vieira-Cruz D, Chibbaro A, Ghidoni D, Kile T, Barkley WE, Vilchèze C, Colon-Berezin C, Thaler DS, Larsen MH, Sturm AW, Jacobs WR. Einstein Contained Aerosol Pulmonizer (ECAP): Improved Biosafety for Multi-Drug Resistant (MDR) and Extensively Drug Resistant (XDR) Mycobacterium tuberculosis Aerosol Infection Studies. Applied Biosafety : Journal of the American Biological Safety Association. 16: 134-138. PMID 23413363 DOI: 10.1177/153567601101600302 |
0.417 |
|
| 2011 |
Parra M, Derrick SC, Yang A, Tian J, Kolibab K, Oakley M, Perera LP, Jacobs WR, Kumar S, Morris SL. Malaria infections do not compromise vaccine-induced immunity against tuberculosis in mice. Plos One. 6: e28164. PMID 22205939 DOI: 10.1371/Journal.Pone.0028164 |
0.433 |
|
| 2011 |
Pope WH, Ferreira CM, Jacobs-Sera D, Benjamin RC, Davis AJ, DeJong RJ, Elgin SC, Guilfoile FR, Forsyth MH, Harris AD, Harvey SE, Hughes LE, Hynes PM, Jackson AS, Jalal MD, ... ... Jacobs WR, et al. Cluster K mycobacteriophages: insights into the evolutionary origins of mycobacteriophage TM4. Plos One. 6: e26750. PMID 22053209 DOI: 10.1371/Journal.Pone.0026750 |
0.325 |
|
| 2011 |
Jain P, Thaler DS, Maiga M, Timmins GS, Bishai WR, Hatfull GF, Larsen MH, Jacobs WR. Reporter phage and breath tests: emerging phenotypic assays for diagnosing active tuberculosis, antibiotic resistance, and treatment efficacy. The Journal of Infectious Diseases. 204: S1142-50. PMID 21996696 DOI: 10.1093/Infdis/Jir454 |
0.397 |
|
| 2011 |
Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, ... ... Jacobs WR, et al. A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nature Medicine. 17: 1261-8. PMID 21892180 DOI: 10.1038/Nm.2420 |
0.456 |
|
| 2011 |
Pruksakorn P, Arai M, Liu L, Moodley P, Jacobs WR, Kobayashi M. Action-mechanism of trichoderin A, an anti-dormant mycobacterial aminolipopeptide from marine sponge-derived Trichoderma sp. Biological & Pharmaceutical Bulletin. 34: 1287-90. PMID 21804219 DOI: 10.1248/Bpb.34.1287 |
0.39 |
|
| 2011 |
Sayahi H, Zimhony O, Jacobs WR, Shekhtman A, Welch JT. Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase I. Bioorganic & Medicinal Chemistry Letters. 21: 4804-7. PMID 21775138 DOI: 10.1016/J.Bmcl.2011.06.055 |
0.316 |
|
| 2011 |
Wong KW, Jacobs WR. Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis. Cellular Microbiology. 13: 1371-84. PMID 21740493 DOI: 10.1111/J.1462-5822.2011.01625.X |
0.46 |
|
| 2011 |
Vilchèze C, Av-Gay Y, Barnes SW, Larsen MH, Walker JR, Glynne RJ, Jacobs WR. Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis. Antimicrobial Agents and Chemotherapy. 55: 4422-3. PMID 21709101 DOI: 10.1128/Aac.00564-11 |
0.354 |
|
| 2011 |
Vilchèze C, Baughn AD, Tufariello J, Leung LW, Kuo M, Basler CF, Alland D, Sacchettini JC, Freundlich JS, Jacobs WR. Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions. Antimicrobial Agents and Chemotherapy. 55: 3889-98. PMID 21628538 DOI: 10.1128/Aac.00266-11 |
0.442 |
|
| 2011 |
Xu X, Vilchèze C, Av-Gay Y, Gómez-Velasco A, Jacobs WR. Precise null deletion mutations of the mycothiol synthesis genes reveal their role in isoniazid and ethionamide resistance in Mycobacterium smegmatis. Antimicrobial Agents and Chemotherapy. 55: 3133-9. PMID 21502624 DOI: 10.1128/Aac.00020-11 |
0.392 |
|
| 2011 |
Prados-Rosales R, Baena A, Martinez LR, Luque-Garcia J, Kalscheuer R, Veeraraghavan U, Camara C, Nosanchuk JD, Besra GS, Chen B, Jimenez J, Glatman-Freedman A, Jacobs WR, Porcelli SA, Casadevall A. Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice. The Journal of Clinical Investigation. 121: 1471-83. PMID 21364279 DOI: 10.1172/Jci44261 |
0.391 |
|
| 2011 |
Rondón L, Piuri M, Jacobs WR, de Waard J, Hatfull GF, Takiff HE. Evaluation of fluoromycobacteriophages for detecting drug resistance in Mycobacterium tuberculosis. Journal of Clinical Microbiology. 49: 1838-42. PMID 21346042 DOI: 10.1128/Jcm.02476-10 |
0.409 |
|
| 2011 |
Hinchey J, Jeon BY, Alley H, Chen B, Goldberg M, Derrick S, Morris S, Jacobs WR, Porcelli SA, Lee S. Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis. Plos One. 6: e15857. PMID 21264335 DOI: 10.1371/Journal.Pone.0015857 |
0.481 |
|
| 2011 |
Yu JS, Whitesides J, Lee SH, Taylor N, Jacobs WR, Letvin NL, Haynes BF. Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression. Clinical and Vaccine Immunology : Cvi. 18: 43-9. PMID 21068210 DOI: 10.1128/Cvi.00292-10 |
0.319 |
|
| 2010 |
Kalscheuer R, Jacobs WR. The significance of GlgE as a new target for tuberculosis. Drug News & Perspectives. 23: 619-24. PMID 21180647 DOI: 10.1358/Dnp.2010.23.10.1534855 |
0.474 |
|
| 2010 |
Molle V, Gulten G, Vilchèze C, Veyron-Churlet R, Zanella-Cléon I, Sacchettini JC, Jacobs WR, Kremer L. Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Molecular Microbiology. 78: 1591-605. PMID 21143326 DOI: 10.1111/J.1365-2958.2010.07446.X |
0.448 |
|
| 2010 |
Kalscheuer R, Weinrick B, Veeraraghavan U, Besra GS, Jacobs WR. Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 21761-6. PMID 21118978 DOI: 10.1073/Pnas.1014642108 |
0.357 |
|
| 2010 |
Baughn AD, Deng J, Vilchèze C, Riestra A, Welch JT, Jacobs WR, Zimhony O. Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy. Antimicrobial Agents and Chemotherapy. 54: 5323-8. PMID 20876380 DOI: 10.1128/Aac.00529-10 |
0.437 |
|
| 2010 |
Lázár-Molnár E, Chen B, Sweeney KA, Wang EJ, Liu W, Lin J, Porcelli SA, Almo SC, Nathenson SG, Jacobs WR. Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 13402-7. PMID 20624978 DOI: 10.1073/Pnas.1007394107 |
0.311 |
|
| 2010 |
Wang F, Jain P, Gulten G, Liu Z, Feng Y, Ganesula K, Motiwala AS, Ioerger TR, Alland D, Vilchèze C, Jacobs WR, Sacchettini JC. Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid. Antimicrobial Agents and Chemotherapy. 54: 3776-82. PMID 20566771 DOI: 10.1128/Aac.00453-10 |
0.502 |
|
| 2010 |
Pruksakorn P, Arai M, Kotoku N, Vilchèze C, Baughn AD, Moodley P, Jacobs WR, Kobayashi M. Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria. Bioorganic & Medicinal Chemistry Letters. 20: 3658-63. PMID 20483615 DOI: 10.1016/J.Bmcl.2010.04.100 |
0.34 |
|
| 2010 |
Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC. Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. Journal of Bacteriology. 192: 3645-53. PMID 20472797 DOI: 10.1128/Jb.00166-10 |
0.358 |
|
| 2010 |
Larsen MH, Jacobs WR, Porcelli SA, Kim J, Ranganathan UD, Fennelly GJ. Balancing safety and immunogenicity in live-attenuated mycobacterial vaccines for use in humans at risk for HIV: response to misleading comments in Ranganathan et al. "recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice". Vaccine. 28: 3633-4. PMID 20347058 DOI: 10.1016/J.Vaccine.2010.03.025 |
0.397 |
|
| 2010 |
Kalscheuer R, Syson K, Veeraraghavan U, Weinrick B, Biermann KE, Liu Z, Sacchettini JC, Besra G, Bornemann S, Jacobs WR. Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway. Nature Chemical Biology. 6: 376-84. PMID 20305657 DOI: 10.1038/Nchembio.340 |
0.41 |
|
| 2010 |
Vilchèze C, Weinrick B, Wong KW, Chen B, Jacobs WR. NAD+ auxotrophy is bacteriocidal for the tubercle bacilli. Molecular Microbiology. 76: 365-77. PMID 20199601 DOI: 10.1111/J.1365-2958.2010.07099.X |
0.455 |
|
| 2010 |
Kinhikar AG, Verma I, Chandra D, Singh KK, Weldingh K, Andersen P, Hsu T, Jacobs WR, Laal S. Potential role for ESAT6 in dissemination of M. tuberculosis via human lung epithelial cells. Molecular Microbiology. 75: 92-106. PMID 19906174 DOI: 10.1111/J.1365-2958.2009.06959.X |
0.361 |
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| 2009 |
Bhatt A, Jacobs WR. Gene essentiality testing in mycobacterium smegmatis using specialized transduction. Methods in Molecular Biology (Clifton, N.J.). 465: 325-36. PMID 20560066 DOI: 10.1007/978-1-59745-207-6_22 |
0.313 |
|
| 2009 |
Baughn AD, Garforth SJ, Vilchèze C, Jacobs WR. An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis. Plos Pathogens. 5: e1000662. PMID 19936047 DOI: 10.1371/Journal.Ppat.1000662 |
0.438 |
|
| 2009 |
Ioerger TR, Koo S, No EG, Chen X, Larsen MH, Jacobs WR, Pillay M, Sturm AW, Sacchettini JC. Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa. Plos One. 4: e7778. PMID 19890396 DOI: 10.1371/Journal.Pone.0007778 |
0.361 |
|
| 2009 |
Capyk JK, Kalscheuer R, Stewart GR, Liu J, Kwon H, Zhao R, Okamoto S, Jacobs WR, Eltis LD, Mohn WW. Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. The Journal of Biological Chemistry. 284: 35534-42. PMID 19846551 DOI: 10.1074/Jbc.M109.072132 |
0.419 |
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| 2009 |
Ranganathan UD, Larsen MH, Kim J, Porcelli SA, Jacobs WR, Fennelly GJ. Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice. Vaccine. 28: 152-61. PMID 19808028 DOI: 10.1016/J.Vaccine.2009.09.087 |
0.38 |
|
| 2009 |
Nascimento IP, Dias WO, Quintilio W, Hsu T, Jacobs WR, Leite LC. Construction of an unmarked recombinant BCG expressing a pertussis antigen by auxotrophic complementation: protection against Bordetella pertussis challenge in neonates. Vaccine. 27: 7346-51. PMID 19782111 DOI: 10.1016/J.Vaccine.2009.09.043 |
0.355 |
|
| 2009 |
Chen J, Kriakov J, Singh A, Jacobs WR, Besra GS, Bhatt A. Defects in glycopeptidolipid biosynthesis confer phage I3 resistance in Mycobacterium smegmatis. Microbiology (Reading, England). 155: 4050-7. PMID 19744987 DOI: 10.1099/Mic.0.033209-0 |
0.414 |
|
| 2009 |
Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Estes DM, Larsen MH, Jacobs WR, Andersen P, McNair J, Minion FC, Lyashchenko KP, Hewinson RG, Vordermeier HM, Sacco RE. Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria. Plos One. 4: e6414. PMID 19641628 DOI: 10.1371/Journal.Pone.0006414 |
0.409 |
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| 2009 |
Venkataswamy MM, Baena A, Goldberg MF, Bricard G, Im JS, Chan J, Reddington F, Besra GS, Jacobs WR, Porcelli SA. Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin. Journal of Immunology (Baltimore, Md. : 1950). 183: 1644-56. PMID 19620317 DOI: 10.4049/Jimmunol.0900858 |
0.405 |
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| 2009 |
Banaei N, Kincaid EZ, Lin SY, Desmond E, Jacobs WR, Ernst JD. Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green. Antimicrobial Agents and Chemotherapy. 53: 3799-802. PMID 19596883 DOI: 10.1128/Aac.00647-09 |
0.456 |
|
| 2009 |
Larsen MH, Biermann K, Chen B, Hsu T, Sambandamurthy VK, Lackner AA, Aye PP, Didier P, Huang D, Shao L, Wei H, Letvin NL, Frothingham R, Haynes BF, Chen ZW, ... Jacobs WR, et al. Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates. Vaccine. 27: 4709-17. PMID 19500524 DOI: 10.1016/J.Vaccine.2009.05.050 |
0.399 |
|
| 2009 |
Parra M, Yang AL, Lim J, Kolibab K, Derrick S, Cadieux N, Perera LP, Jacobs WR, Brennan M, Morris SL. Development of a murine mycobacterial growth inhibition assay for evaluating vaccines against Mycobacterium tuberculosis. Clinical and Vaccine Immunology : Cvi. 16: 1025-32. PMID 19458207 DOI: 10.1128/Cvi.00067-09 |
0.448 |
|
| 2009 |
Chen CY, Huang D, Wang RC, Shen L, Zeng G, Yao S, Shen Y, Halliday L, Fortman J, McAllister M, Estep J, Hunt R, Vasconcelos D, Du G, Porcelli SA, ... ... Jacobs WR, et al. A critical role for CD8 T cells in a nonhuman primate model of tuberculosis. Plos Pathogens. 5: e1000392. PMID 19381260 DOI: 10.1371/Journal.Ppat.1000392 |
0.431 |
|
| 2009 |
Cirillo SL, Subbian S, Chen B, Weisbrod TR, Jacobs WR, Cirillo JD. Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination. Infection and Immunity. 77: 2557-67. PMID 19349422 DOI: 10.1128/Iai.01481-08 |
0.462 |
|
| 2009 |
Gopalaswamy R, Narayanan S, Chen B, Jacobs WR, Av-Gay Y. The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection. Fems Microbiology Letters. 295: 23-9. PMID 19341393 DOI: 10.1111/J.1574-6968.2009.01570.X |
0.431 |
|
| 2009 |
Piuri M, Jacobs WR, Hatfull GF. Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis. Plos One. 4: e4870. PMID 19300517 DOI: 10.1371/Journal.Pone.0004870 |
0.44 |
|
| 2009 |
Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR, Strynadka N, Eltis LD. Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. Plos Pathogens. 5: e1000344. PMID 19300498 DOI: 10.1371/Journal.Ppat.1000344 |
0.423 |
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| 2009 |
Cayabyab MJ, Korioth-Schmitz B, Sun Y, Carville A, Balachandran H, Miura A, Carlson KR, Buzby AP, Haynes BF, Jacobs WR, Letvin NL. Recombinant Mycobacterium bovis BCG prime-recombinant adenovirus boost vaccination in rhesus monkeys elicits robust polyfunctional simian immunodeficiency virus-specific T-cell responses. Journal of Virology. 83: 5505-13. PMID 19297477 DOI: 10.1128/Jvi.02544-08 |
0.345 |
|
| 2009 |
Colangeli R, Haq A, Arcus VL, Summers E, Magliozzo RS, McBride A, Mitra AK, Radjainia M, Khajo A, Jacobs WR, Salgame P, Alland D. The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates. Proceedings of the National Academy of Sciences of the United States of America. 106: 4414-8. PMID 19237572 DOI: 10.1073/Pnas.0810126106 |
0.449 |
|
| 2009 |
Zimmerman DM, Waters WR, Lyashchenko KP, Nonnecke BJ, Armstrong DL, Jacobs WR, Larsen MH, Egan E, Dean GA. Safety and immunogenicity of the Mycobacterium tuberculosis DeltalysA DeltapanCD vaccine in domestic cats infected with feline immunodeficiency virus. Clinical and Vaccine Immunology : Cvi. 16: 427-9. PMID 19144788 DOI: 10.1128/Cvi.00396-08 |
0.367 |
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| 2009 |
Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Scherer CF, Estes DM, Hewinson RG, Vordermeier HM, Barnes SW, Federe GC, Walker JR, Glynne RJ, Hsu T, Weinrick B, Biermann K, ... ... Jacobs WR, et al. Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves. Vaccine. 27: 1201-9. PMID 19135497 DOI: 10.1016/J.Vaccine.2008.12.018 |
0.45 |
|
| 2009 |
Freundlich JS, Wang F, Vilchèze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR, Sacchettini JC. Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis. Chemmedchem. 4: 241-8. PMID 19130456 DOI: 10.1002/Cmdc.200800261 |
0.425 |
|
| 2009 |
Lee WL, Gold B, Darby C, Brot N, Jiang X, de Carvalho LP, Wellner D, St John G, Jacobs WR, Nathan C. Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite. Molecular Microbiology. 71: 583-93. PMID 19040639 DOI: 10.1111/J.1365-2958.2008.06548.X |
0.425 |
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| 2009 |
Lim J, Derrick SC, Kolibab K, Yang AL, Porcelli S, Jacobs WR, Morris SL. Early pulmonary cytokine and chemokine responses in mice immunized with three different vaccines against Mycobacterium tuberculosis determined by PCR array. Clinical and Vaccine Immunology : Cvi. 16: 122-6. PMID 19038785 DOI: 10.1128/Cvi.00359-08 |
0.403 |
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| 2009 |
Endsley JJ, Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Jacobs WR, Larsen MH, Hogg A, Shell E, McAlauy M, Scherer CF, Coffey T, Howard CJ, Villareal-Ramos B, Estes DM. The calf model of immunity for development of a vaccine against tuberculosis. Veterinary Immunology and Immunopathology. 128: 199-204. PMID 19027175 DOI: 10.1016/J.Vetimm.2008.10.312 |
0.418 |
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| 2008 |
Bueno SM, González PA, Cautivo KM, Mora JE, Leiva ED, Tobar HE, Fennelly GJ, Eugenin EA, Jacobs WR, Riedel CA, Kalergis AM. Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG. Proceedings of the National Academy of Sciences of the United States of America. 105: 20822-7. PMID 19075247 DOI: 10.1073/Pnas.0806244105 |
0.349 |
|
| 2008 |
Qiu L, Huang D, Chen CY, Wang R, Shen L, Shen Y, Hunt R, Estep J, Haynes BF, Jacobs WR, Letvin N, Du G, Chen ZW. Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but low antigen-specific cellular responses. The Journal of Infectious Diseases. 198: 1514-9. PMID 18811584 DOI: 10.1086/592448 |
0.355 |
|
| 2008 |
Porcelli SA, Jacobs WR. Tuberculosis: unsealing the apoptotic envelope. Nature Immunology. 9: 1101-2. PMID 18800161 DOI: 10.1038/Ni1008-1101 |
0.393 |
|
| 2008 |
Vilchèze C, Av-Gay Y, Attarian R, Liu Z, Hazbón MH, Colangeli R, Chen B, Liu W, Alland D, Sacchettini JC, Jacobs WR. Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis. Molecular Microbiology. 69: 1316-29. PMID 18651841 DOI: 10.1111/J.1365-2958.2008.06365.X |
0.483 |
|
| 2008 |
Arai M, Sobou M, Vilchéze C, Baughn A, Hashizume H, Pruksakorn P, Ishida S, Matsumoto M, Jacobs WR, Kobayashi M. Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent. Bioorganic & Medicinal Chemistry. 16: 6732-6. PMID 18556206 DOI: 10.1016/J.Bmc.2008.05.061 |
0.463 |
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| 2008 |
Dao DN, Sweeney K, Hsu T, Gurcha SS, Nascimento IP, Roshevsky D, Besra GS, Chan J, Porcelli SA, Jacobs WR. Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production. Plos Pathogens. 4: e1000081. PMID 18535659 DOI: 10.1371/Journal.Ppat.1000081 |
0.389 |
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| 2008 |
Kumar V, Loganathan P, Sivaramakrishnan G, Kriakov J, Dusthakeer A, Subramanyam B, Chan J, Jacobs WR, Paranji Rama N. Characterization of temperate phage Che12 and construction of a new tool for diagnosis of tuberculosis. Tuberculosis (Edinburgh, Scotland). 88: 616-23. PMID 18511339 DOI: 10.1016/J.Tube.2008.02.007 |
0.489 |
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| 2008 |
Mohamedmohaideen NN, Palaninathan SK, Morin PM, Williams BJ, Braunstein M, Tichy SE, Locker J, Russell DH, Jacobs WR, Sacchettini JC. Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis. Biochemistry. 47: 6092-102. PMID 18479146 DOI: 10.1021/Bi701929M |
0.612 |
|
| 2008 |
Ojha AK, Baughn AD, Sambandan D, Hsu T, Trivelli X, Guerardel Y, Alahari A, Kremer L, Jacobs WR, Hatfull GF. Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria. Molecular Microbiology. 69: 164-74. PMID 18466296 DOI: 10.1111/J.1365-2958.2008.06274.X |
0.443 |
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| 2008 |
Mishra AK, Alderwick LJ, Rittmann D, Wang C, Bhatt A, Jacobs WR, Takayama K, Eggeling L, Besra GS. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Molecular Microbiology. 68: 1595-613. PMID 18452585 DOI: 10.1111/J.1365-2958.2008.06265.X |
0.336 |
|
| 2008 |
Im JS, Kang TJ, Lee SB, Kim CH, Lee SH, Venkataswamy MM, Serfass ER, Chen B, Illarionov PA, Besra GS, Jacobs WR, Chae GT, Porcelli SA. Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections. Clinical Immunology (Orlando, Fla.). 127: 214-24. PMID 18308638 DOI: 10.1016/J.Clim.2007.12.005 |
0.424 |
|
| 2008 |
Reddy MC, Gokulan K, Jacobs WR, Ioerger TR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Science : a Publication of the Protein Society. 17: 159-70. PMID 18042675 DOI: 10.1110/Ps.073192208 |
0.399 |
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| 2008 |
Gopalaswamy R, Narayanan S, Jacobs WR, Av-Gay Y. Mycobacterium smegmatis biofilm formation and sliding motility are affected by the serine/threonine protein kinase PknF. Fems Microbiology Letters. 278: 121-7. PMID 18031532 DOI: 10.1111/J.1574-6968.2007.00989.X |
0.346 |
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| 2008 |
Banaiee N, January V, Barthus C, Lambrick M, Roditi D, Behr MA, Jacobs WR, Steyn LM. Evaluation of a semi-automated reporter phage assay for susceptibility testing of Mycobacterium tuberculosis isolates in South Africa. Tuberculosis (Edinburgh, Scotland). 88: 64-8. PMID 17980664 DOI: 10.1016/J.Tube.2007.08.006 |
0.361 |
|
| 2008 |
Huang D, Shen Y, Qiu L, Chen CY, Shen L, Estep J, Hunt R, Vasconcelos D, Du G, Aye P, Lackner AA, Larsen MH, Jacobs WR, Haynes BF, Letvin NL, et al. Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection. Infection and Immunity. 76: 426-36. PMID 17923514 DOI: 10.1128/Iai.01008-07 |
0.399 |
|
| 2008 |
Jayakumar D, Jacobs WR, Narayanan S. Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection. Cellular Microbiology. 10: 365-74. PMID 17892498 DOI: 10.1111/J.1462-5822.2007.01049.X |
0.426 |
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| 2008 |
Daugelat S, Jacobs WR. The Mycobacterium tuberculosis recA intein can be used in an ORFTRAP to select for open reading frames. Protein Science. 8: 644-653. PMID 10091667 DOI: 10.1110/Ps.8.3.644 |
0.36 |
|
| 2008 |
Miesel L, Rozwarski DA, Sacchettini JC, Jacobs WR. Mechanisms for isoniazid action and resistance. Novartis Foundation Symposium. 217: 209-221. PMID 9949810 DOI: 10.1002/0470846526.Ch15 |
0.406 |
|
| 2007 |
Larsen MH, Biermann K, Jacobs WR. Analyses of Mycobacterium tuberculosis proteins. Current Protocols in Microbiology. Unit 10A.4. PMID 18770605 DOI: 10.1002/9780471729259.Mc10A04S6 |
0.432 |
|
| 2007 |
Vilchèze C, Jacobs WR. Isolation and analysis of Mycobacterium tuberculosis mycolic acids. Current Protocols in Microbiology. Unit 10A.3. PMID 18770604 DOI: 10.1002/9780471729259.Mc10A03S05 |
0.417 |
|
| 2007 |
Larsen MH, Biermann K, Tandberg S, Hsu T, Jacobs WR. Genetic Manipulation of Mycobacterium tuberculosis. Current Protocols in Microbiology. Unit 10A.2. PMID 18770603 DOI: 10.1002/9780471729259.Mc10A02S6 |
0.398 |
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| 2007 |
Larsen MH, Biermann K, Jacobs WR. Laboratory maintenance of Mycobacterium tuberculosis. Current Protocols in Microbiology. Unit 10A.1. PMID 18770602 DOI: 10.1002/9780471729259.Mc10A01S6 |
0.394 |
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| 2007 |
Vilchèze C, Jacobs WR. The mechanism of isoniazid killing: clarity through the scope of genetics. Annual Review of Microbiology. 61: 35-50. PMID 18035606 DOI: 10.1146/Annurev.Micro.61.111606.122346 |
0.464 |
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| 2007 |
Murillo AC, Li HY, Alber T, Baker EN, Berger JM, Cherney LT, Cherney MM, Cho YS, Eisenberg D, Garen CR, Goulding CW, Hung LW, Ioerger TR, Jacobs WR, James MN, et al. High throughput crystallography of TB drug targets. Infectious Disorders Drug Targets. 7: 127-39. PMID 17970224 DOI: 10.2174/187152607781001853 |
0.416 |
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| 2007 |
Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Scherer CF, Estes DM, Jacobs WR, Glatman-Freedman A, Larsen MH. Failure of a Mycobacterium tuberculosis DeltaRD1 DeltapanCD double deletion mutant in a neonatal calf aerosol M. bovis challenge model: comparisons to responses elicited by M. bovis bacille Calmette Guerin. Vaccine. 25: 7832-40. PMID 17931755 DOI: 10.1016/J.Vaccine.2007.08.029 |
0.437 |
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| 2007 |
Al-Sayyed B, Piperdi S, Yuan X, Li A, Besra GS, Jacobs WR, Casadevall A, Glatman-Freedman A. Monoclonal antibodies to Mycobacterium tuberculosis CDC 1551 reveal subcellular localization of MPT51. Tuberculosis (Edinburgh, Scotland). 87: 489-97. PMID 17881291 DOI: 10.1016/J.Tube.2007.07.005 |
0.426 |
|
| 2007 |
Hinchey J, Lee S, Jeon BY, Basaraba RJ, Venkataswamy MM, Chen B, Chan J, Braunstein M, Orme IM, Derrick SC, Morris SL, Jacobs WR, Porcelli SA. Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis. The Journal of Clinical Investigation. 117: 2279-88. PMID 17671656 DOI: 10.1172/Jci31947 |
0.684 |
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| 2007 |
Mo Y, Quanquin NM, Vecino WH, Ranganathan UD, Tesfa L, Bourn W, Derbyshire KM, Letvin NL, Jacobs WR, Fennelly GJ. Genetic alteration of Mycobacterium smegmatis to improve mycobacterium-mediated transfer of plasmid DNA into mammalian cells and DNA immunization. Infection and Immunity. 75: 4804-16. PMID 17664267 DOI: 10.1128/Iai.01877-06 |
0.428 |
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| 2007 |
Velmurugan K, Chen B, Miller JL, Azogue S, Gurses S, Hsu T, Glickman M, Jacobs WR, Porcelli SA, Briken V. Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells. Plos Pathogens. 3: e110. PMID 17658950 DOI: 10.1371/Journal.Ppat.0030110 |
0.626 |
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| 2007 |
Pinto R, Harrison JS, Hsu T, Jacobs WR, Leyh TS. Sulfite reduction in mycobacteria. Journal of Bacteriology. 189: 6714-22. PMID 17644602 DOI: 10.1128/Jb.00487-07 |
0.377 |
|
| 2007 |
Colangeli R, Helb D, Vilchèze C, Hazbón MH, Lee CG, Safi H, Sayers B, Sardone I, Jones MB, Fleischmann RD, Peterson SN, Jacobs WR, Alland D. Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis. Plos Pathogens. 3: e87. PMID 17590082 DOI: 10.1371/Journal.Ppat.0030087 |
0.478 |
|
| 2007 |
Banaiee N, Jacobs WR, Ernst JD. LspA-independent action of globomycin on Mycobacterium tuberculosis. The Journal of Antimicrobial Chemotherapy. 60: 414-6. PMID 17579235 DOI: 10.1093/Jac/Dkm223 |
0.41 |
|
| 2007 |
Bhatt A, Molle V, Besra GS, Jacobs WR, Kremer L. The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development. Molecular Microbiology. 64: 1442-54. PMID 17555433 DOI: 10.1111/J.1365-2958.2007.05761.X |
0.323 |
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| 2007 |
Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR. The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis. Journal of Bacteriology. 189: 5495-503. PMID 17526710 DOI: 10.1128/Jb.00190-07 |
0.304 |
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| 2007 |
Ngo SC, Zimhony O, Chung WJ, Sayahi H, Jacobs WR, Welch JT. Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs. Antimicrobial Agents and Chemotherapy. 51: 2430-5. PMID 17485499 DOI: 10.1128/Aac.01458-06 |
0.387 |
|
| 2007 |
Bhatt A, Fujiwara N, Bhatt K, Gurcha SS, Kremer L, Chen B, Chan J, Porcelli SA, Kobayashi K, Besra GS, Jacobs WR. Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 5157-62. PMID 17360388 DOI: 10.1073/Pnas.0608654104 |
0.484 |
|
| 2007 |
Bhatt K, Gurcha SS, Bhatt A, Besra GS, Jacobs WR. Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis. Microbiology (Reading, England). 153: 513-20. PMID 17259623 DOI: 10.1099/Mic.0.2006/003103-0 |
0.458 |
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| 2007 |
Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR, Sacchettini JC. Mechanism of thioamide drug action against tuberculosis and leprosy. The Journal of Experimental Medicine. 204: 73-8. PMID 17227913 DOI: 10.1084/Jem.20062100 |
0.447 |
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| 2007 |
Derrick SC, Evering TH, Sambandamurthy VK, Jalapathy KV, Hsu T, Chen B, Chen M, Russell RG, Junqueira-Kipnis AP, Orme IM, Porcelli SA, Jacobs WR, Morris SL. Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine. Immunology. 120: 192-206. PMID 17076705 DOI: 10.1111/J.1365-2567.2006.02491.X |
0.362 |
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| 2007 |
Hovav AH, Cayabyab MJ, Panas MW, Santra S, Greenland J, Geiben R, Haynes BF, Jacobs WR, Letvin NL. Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis. Journal of Virology. 81: 74-83. PMID 17050608 DOI: 10.1128/Jvi.01269-06 |
0.3 |
|
| 2006 |
Lee S, Jeon BY, Bardarov S, Chen M, Morris SL, Jacobs WR. Protection elicited by two glutamine auxotrophs of Mycobacterium tuberculosis and in vivo growth phenotypes of the four unique glutamine synthetase mutants in a murine model. Infection and Immunity. 74: 6491-5. PMID 17057098 DOI: 10.1128/Iai.00531-06 |
0.484 |
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| 2006 |
Junqueira-Kipnis AP, Basaraba RJ, Gruppo V, Palanisamy G, Turner OC, Hsu T, Jacobs WR, Fulton SA, Reba SM, Boom WH, Orme IM. Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma. Immunology. 119: 224-31. PMID 17005003 DOI: 10.1111/J.1365-2567.2006.02427.X |
0.4 |
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| 2006 |
Yu JS, Peacock JW, Vanleeuwen S, Hsu T, Jacobs WR, Cayabyab MJ, Letvin NL, Frothingham R, Staats HF, Liao HX, Haynes BF. Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis. Clinical and Vaccine Immunology : Cvi. 13: 1204-11. PMID 16943347 DOI: 10.1128/Cvi.00195-06 |
0.312 |
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| 2006 |
Banaiee N, Jacobs WR, Ernst JD. Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages Infection and Immunity. 74: 6449-6457. PMID 16923787 DOI: 10.1128/Iai.00190-06 |
0.459 |
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| 2006 |
Vilchèze C, Wang F, Arai M, Hazbón MH, Colangeli R, Kremer L, Weisbrod TR, Alland D, Sacchettini JC, Jacobs WR. Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nature Medicine. 12: 1027-9. PMID 16906155 DOI: 10.1038/Nm1466 |
0.432 |
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| 2006 |
Pérez J, Garcia R, Bach H, de Waard JH, Jacobs WR, Av-Gay Y, Bubis J, Takiff HE. Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD. Biochemical and Biophysical Research Communications. 348: 6-12. PMID 16879801 DOI: 10.1016/J.Bbrc.2006.06.164 |
0.366 |
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| 2006 |
Nkrumah LJ, Muhle RA, Moura PA, Ghosh P, Hatfull GF, Jacobs WR, Fidock DA. Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase. Nature Methods. 3: 615-21. PMID 16862136 DOI: 10.1038/Nmeth904 |
0.302 |
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| 2006 |
Sambandamurthy VK, Derrick SC, Hsu T, Chen B, Larsen MH, Jalapathy KV, Chen M, Kim J, Porcelli SA, Chan J, Morris SL, Jacobs WR. Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis. Vaccine. 24: 6309-20. PMID 16860907 DOI: 10.1016/J.Vaccine.2006.05.097 |
0.484 |
|
| 2006 |
Rao V, Gao F, Chen B, Jacobs WR, Glickman MS. Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence. The Journal of Clinical Investigation. 116: 1660-7. PMID 16741578 DOI: 10.1172/Jci27335 |
0.625 |
|
| 2006 |
Aravindhan V, Narayanan S, Gautham N, Prasad V, Kannan P, Jacobs WR, Narayanan P. T-h-2 immunity and CD3+CD45RBlow-activated T cells in mice immunized with recombinant bacillus Calmette-Guérin expressing HIV-1 principal neutralizing determinant epitope. Fems Immunology and Medical Microbiology. 47: 45-55. PMID 16706787 DOI: 10.1111/J.1574-695X.2006.00061.X |
0.355 |
|
| 2006 |
Tufariello JM, Mi K, Xu J, Manabe YC, Kesavan AK, Drumm J, Tanaka K, Jacobs WR, Chan J. Deletion of the Mycobacterium tuberculosis resuscitation-promoting factor Rv1009 gene results in delayed reactivation from chronic tuberculosis Infection and Immunity. 74: 2985-2995. PMID 16622237 DOI: 10.1128/Iai.74.5.2985-2995.2006 |
0.482 |
|
| 2006 |
Banaiee N, Kincaid EZ, Buchwald U, Jacobs WR, Ernst JD. Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. Journal of Immunology (Baltimore, Md. : 1950). 176: 3019-27. PMID 16493060 DOI: 10.4049/Jimmunol.176.5.3019 |
0.442 |
|
| 2006 |
Freundlich JS, Yu M, Lucumi E, Kuo M, Tsai HC, Valderramos JC, Karagyozov L, Jacobs WR, Schiehser GA, Fidock DA, Jacobus DP, Sacchettini JC. Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives. Bioorganic & Medicinal Chemistry Letters. 16: 2163-9. PMID 16466916 DOI: 10.1016/J.Bmcl.2006.01.051 |
0.312 |
|
| 2006 |
Cayabyab MJ, Hovav AH, Hsu T, Krivulka GR, Lifton MA, Gorgone DA, Fennelly GJ, Haynes BF, Jacobs WR, Letvin NL. Generation of CD8+ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env. Journal of Virology. 80: 1645-52. PMID 16439521 DOI: 10.1128/Jvi.80.4.1645-1652.2006 |
0.38 |
|
| 2006 |
Govan VA, Christensen ND, Berkower C, Jacobs WR, Williamson AL. Immunisation with recombinant BCG expressing the cottontail rabbit papillomavirus (CRPV) L1 gene provides protection from CRPV challenge Vaccine. 24: 2087-2093. PMID 16343704 DOI: 10.1016/J.Vaccine.2005.11.029 |
0.329 |
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| 2006 |
Roy E, De Silva AD, Sambandamurthy VK, Clark SO, Stavropoulos E, Jacobs WR, Brennan J, Chan J, Williams A, Colston MJ, Tascon RE. Induction of high levels of protective immunity in mice after vaccination using dendritic cells infected with auxotrophic mutants of Mycobacterium tuberculosis Immunology Letters. 103: 196-199. PMID 16297449 DOI: 10.1016/J.Imlet.2005.10.011 |
0.42 |
|
| 2005 |
Ojha A, Anand M, Bhatt A, Kremer L, Jacobs WR, Hatfull GF. GroEL1: a dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria. Cell. 123: 861-73. PMID 16325580 DOI: 10.1016/J.Cell.2005.09.012 |
0.327 |
|
| 2005 |
Bhatt A, Kremer L, Dai AZ, Sacchettini JC, Jacobs WR. Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis. Journal of Bacteriology. 187: 7596-606. PMID 16267284 DOI: 10.1128/Jb.187.22.7596-7606.2005 |
0.374 |
|
| 2005 |
Sambandamurthy VK, Jacobs WR. Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis. Microbes and Infection. 7: 955-961. PMID 15914065 DOI: 10.1016/J.Micinf.2005.04.001 |
0.474 |
|
| 2005 |
Colangeli R, Helb D, Sridharan S, Sun J, Varma-Basil M, Hazbón MH, Harbacheuski R, Megjugorac NJ, Jacobs WR, Holzenburg A, Sacchettini JC, Alland D. The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol. Molecular Microbiology. 55: 1829-40. PMID 15752203 DOI: 10.1111/J.1365-2958.2005.04510.X |
0.517 |
|
| 2005 |
Vilchèze C, Weisbrod TR, Chen B, Kremer L, Hazbón MH, Wang F, Alland D, Sacchettini JC, Jacobs WR. Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria. Antimicrobial Agents and Chemotherapy. 49: 708-20. PMID 15673755 DOI: 10.1128/Aac.49.2.708-720.2005 |
0.403 |
|
| 2005 |
Sambandamurthy VK, Derrick SC, Jalapathy KV, Chen B, Russell RG, Morris SL, Jacobs WR. Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis. Infection and Immunity. 73: 1196-203. PMID 15664964 DOI: 10.1128/Iai.73.2.1196-1203.2005 |
0.386 |
|
| 2004 |
Matsunaga I, Bhatt A, Young DC, Cheng TY, Eyles SJ, Besra GS, Briken V, Porcelli SA, Costello CE, Jacobs WR, Moody DB. Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. The Journal of Experimental Medicine. 200: 1559-69. PMID 15611286 DOI: 10.1084/Jem.20041429 |
0.43 |
|
| 2004 |
Lee S, Kriakov J, Vilcheze C, Dai Z, Hatfull GF, Jacobs WR. Bxz1, a new generalized transducing phage for mycobacteria. Fems Microbiology Letters. 241: 271-6. PMID 15598543 DOI: 10.1016/J.Femsle.2004.10.032 |
0.348 |
|
| 2004 |
Hisert KB, Kirksey MA, Gomez JE, Sousa AO, Cox JS, Jacobs WR, Nathan CF, McKinney JD. Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening. Infection and Immunity. 72: 5315-21. PMID 15322028 DOI: 10.1128/Iai.72.9.5315-5321.2004 |
0.724 |
|
| 2004 |
Glatman-Freedman A, Casadevall A, Dai Z, Jacobs WR, Li A, Morris SL, Navoa JA, Piperdi S, Robbins JB, Schneerson R, Schwebach JR, Shapiro M. Antigenic evidence of prevalence and diversity of Mycobacterium tuberculosis arabinomannan. Journal of Clinical Microbiology. 42: 3225-31. PMID 15243086 DOI: 10.1128/Jcm.42.7.3225-3231.2004 |
0.401 |
|
| 2004 |
Zimhony O, Vilchèze C, Jacobs WR. Characterization of Mycobacterium smegmatis expressing the Mycobacterium tuberculosis fatty acid synthase I (fas1) gene. Journal of Bacteriology. 186: 4051-4055. PMID 15205406 DOI: 10.1128/Jb.186.13.4051-4055.2004 |
0.47 |
|
| 2004 |
Sampson SL, Dascher CC, Sambandamurthy VK, Russell RG, Jacobs WR, Bloom BR, Hondalus MK. Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs. Infection and Immunity. 72: 3031-7. PMID 15102816 DOI: 10.1128/Iai.72.5.3031-3037.2004 |
0.467 |
|
| 2004 |
Dao DN, Kremer L, Guérardel Y, Molano A, Jacobs WR, Porcelli SA, Briken V. Mycobacterium tuberculosis Lipomannan Induces Apoptosis and Interleukin-12 Production in Macrophages Infection and Immunity. 72: 2067-2074. PMID 15039328 DOI: 10.1128/Iai.72.4.2067-2074.2004 |
0.393 |
|
| 2004 |
Tufariello JM, Jacobs WR, Chan J. Individual Mycobacterium tuberculosis Resuscitation-Promoting Factor Homologues Are Dispensable for Growth In Vitro and In Vivo Infection and Immunity. 72: 515-526. PMID 14688133 DOI: 10.1128/Iai.72.1.515-526.2004 |
0.478 |
|
| 2003 |
Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, Marks CB, Padiyar J, Goulding C, Gingery M, Eisenberg D, Russell RG, Derrick SC, Collins FM, Morris SL, ... ... Jacobs WR, et al. The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proceedings of the National Academy of Sciences of the United States of America. 100: 12420-5. PMID 14557547 DOI: 10.1073/Pnas.1635213100 |
0.482 |
|
| 2003 |
Hazbón MH, Guarín N, Ferro BE, Rodríguez AL, Labrada LA, Tovar R, Riska PF, Jacobs WR. Photographic and luminometric detection of luciferase reporter phages for drug susceptibility testing of clinical Mycobacterium tuberculosis isolates. Journal of Clinical Microbiology. 41: 4865-9. PMID 14532245 DOI: 10.1128/Jcm.41.10.4865-4869.2003 |
0.412 |
|
| 2003 |
Hingley-Wilson SM, Sambandamurthy VK, Jacobs WR. Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis Nature Immunology. 4: 949-955. PMID 14515128 DOI: 10.1038/Ni981 |
0.406 |
|
| 2003 |
Otero J, Jacobs WR, Glickman MS. Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transduction. Applied and Environmental Microbiology. 69: 5039-44. PMID 12957884 DOI: 10.1128/Aem.69.9.5039-5044.2003 |
0.621 |
|
| 2003 |
Ohno H, Zhu G, Mohan VP, Chu D, Kohno S, Jacobs WR, Chan J. The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis Cellular Microbiology. 5: 637-648. PMID 12925133 DOI: 10.1046/J.1462-5822.2003.00307.X |
0.411 |
|
| 2003 |
Terwilliger TC, Park MS, Waldo GS, Berendzen J, Hung LW, Kim CY, Smith CV, Sacchettini JC, Bellinzoni M, Bossi R, De Rossi E, Mattevi A, Milano A, Riccardi G, Rizzi M, ... ... Jacobs W, et al. The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology. Tuberculosis (Edinburgh, Scotland). 83: 223-49. PMID 12906835 DOI: 10.1016/S1472-9792(03)00051-9 |
0.433 |
|
| 2003 |
Consaul SA, Jacobs WR, Pavelka MS. Extragenic suppression of the requirement for diaminopimelate in diaminopimelate auxotrophs of Mycobacterium smegmatis. Fems Microbiology Letters. 225: 131-5. PMID 12900031 DOI: 10.1016/S0378-1097(03)00502-0 |
0.343 |
|
| 2003 |
Kriakov J, Lee Sh, Jacobs WR. Identification of a Regulated Alkaline Phosphatase, a Cell Surface-Associated Lipoprotein, in Mycobacterium smegmatis Journal of Bacteriology. 185: 4983-4991. PMID 12897018 DOI: 10.1128/Jb.185.16.4983-4991.2003 |
0.407 |
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| 2003 |
Banaiee N, Bobadilla-del-Valle M, Riska PF, Bardarov S, Small PM, Ponce-de-Leon A, Jacobs WR, Hatfull GF, Sifuentes-Osornio J. Rapid identification and susceptibility testing of Mycobacterium tuberculosis from MGIT cultures with luciferase reporter mycobacteriophages. Journal of Medical Microbiology. 52: 557-61. PMID 12808076 DOI: 10.1099/Jmm.0.05149-0 |
0.332 |
|
| 2003 |
Bhatt A, Jacobs WR. Conjugal rites of mycobacteria Nature Genetics. 34: 3-4. PMID 12721541 DOI: 10.1038/Ng0503-3 |
0.33 |
|
| 2003 |
Pedulla ML, Ford ME, Houtz JM, Karthikeyan T, Wadsworth C, Lewis JA, Jacobs-Sera D, Falbo J, Gross J, Pannunzio NR, Brucker W, Kumar V, Kandasamy J, Keenan L, Bardarov S, ... ... Jacobs WR, et al. Origins of highly mosaic mycobacteriophage genomes. Cell. 113: 171-82. PMID 12705866 DOI: 10.1016/S0092-8674(03)00233-2 |
0.327 |
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| 2003 |
Braunstein M, Espinosa BJ, Chan J, Belisle JT, Jacobs WR. SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis. Molecular Microbiology. 48: 453-64. PMID 12675804 DOI: 10.1046/J.1365-2958.2003.03438.X |
0.681 |
|
| 2003 |
Gokulan K, Rupp B, Pavelka MS, Jacobs WR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis. The Journal of Biological Chemistry. 278: 18588-96. PMID 12637582 DOI: 10.1074/Jbc.M301549200 |
0.413 |
|
| 2003 |
Sharma V, Arockiasamy A, Ronning DR, Savva CG, Holzenburg A, Braunstein M, Jacobs WR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase. Proceedings of the National Academy of Sciences of the United States of America. 100: 2243-8. PMID 12606717 DOI: 10.1073/Pnas.0538077100 |
0.564 |
|
| 2003 |
Kuo MR, Morbidoni HR, Alland D, Sneddon SF, Gourlie BB, Staveski MM, Leonard M, Gregory JS, Janjigian AD, Yee C, Musser JM, Kreiswirth B, Iwamoto H, Perozzo R, Jacobs WR, et al. Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. The Journal of Biological Chemistry. 278: 20851-9. PMID 12606558 DOI: 10.1074/Jbc.M211968200 |
0.424 |
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| 2003 |
Bardarov S, Dou H, Eisenach K, Banaiee N, Ya S, Chan J, Jacobs WR, Riska PF. Detection and drug-susceptibility testing of M. tuberculosis from sputum samples using luciferase reporter phage: Comparison with the Mycobacteria Growth Indicator Tube (MGIT) system Diagnostic Microbiology and Infectious Disease. 45: 53-61. PMID 12573551 DOI: 10.1016/S0732-8893(02)00478-9 |
0.399 |
|
| 2002 |
Braunstein M, Bardarov SS, Jacobs WR. Genetic methods for deciphering virulence determinants of Mycobacterium tuberculosis. Methods in Enzymology. 358: 67-99. PMID 12474379 DOI: 10.1016/S0076-6879(02)58081-2 |
0.663 |
|
| 2002 |
Goulding CW, Apostol M, Anderson DH, Gill HS, Smith CV, Kuo MR, Yang JK, Waldo GS, Suh SW, Chauhan R, Kale A, Bachhawat N, Mande SC, Johnston JM, Lott JS, ... ... Jacobs W, et al. The TB structural genomics consortium: providing a structural foundation for drug discovery. Current Drug Targets. Infectious Disorders. 2: 121-41. PMID 12462144 DOI: 10.2174/1568005023342551 |
0.365 |
|
| 2002 |
Larsen MH, Vilchèze C, Kremer L, Besra GS, Parsons L, Salfinger M, Heifets L, Hazbon MH, Alland D, Sacchettini JC, Jacobs WR. Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis Molecular Microbiology. 46: 453-466. PMID 12406221 DOI: 10.1046/J.1365-2958.2002.03162.X |
0.46 |
|
| 2002 |
Sambandamurthy VK, Wang X, Chen B, Russell RG, Derrick S, Collins FM, Morris SL, Jacobs WR. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nature Medicine. 8: 1171-4. PMID 12219086 DOI: 10.1038/Nm765 |
0.475 |
|
| 2002 |
Schwebach JR, Chen B, Glatman-Freedman A, Casadevall A, McKinney JD, Harb JL, McGuire PJ, Barkley WE, Bloom BR, Jacobs WR. Infection of mice with aerosolized Mycobacterium tuberculosis: use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility. Applied and Environmental Microbiology. 68: 4646-9. PMID 12200325 DOI: 10.1128/Aem.68.9.4646-4649.2002 |
0.395 |
|
| 2002 |
Vecino WH, Morin PM, Agha R, Jacobs WR, Fennelly GJ. Mucosal DNA vaccination with highly attenuated Shigella is superior to attenuated Salmonella and comparable to intramuscular DNA vaccination for T cells against HIV. Immunology Letters. 82: 197-204. PMID 12036602 DOI: 10.1016/S0165-2478(02)00043-3 |
0.355 |
|
| 2002 |
Wooff E, Michell SL, Gordon SV, Chambers MA, Bardarov S, Jacobs WR, Hewinson RG, Wheeler PR. Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo. Molecular Microbiology. 43: 653-63. PMID 11929522 DOI: 10.1046/J.1365-2958.2002.02771.X |
0.444 |
|
| 2002 |
Steyn AJ, Collins DM, Hondalus MK, Jacobs WR, Kawakami RP, Bloom BR. Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth. Proceedings of the National Academy of Sciences of the United States of America. 99: 3147-52. PMID 11880648 DOI: 10.1073/Pnas.052705399 |
0.496 |
|
| 2002 |
Perozzo R, Kuo M, Sidhu ABS, Valiyaveettil JT, Bittman R, Jacobs WR, Fidock DA, Sacchettini JC. Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase Journal of Biological Chemistry. 277: 13106-13114. PMID 11792710 DOI: 10.1074/Jbc.M112000200 |
0.334 |
|
| 2002 |
Huang CC, Smith CV, Glickman MS, Jacobs WR, Sacchettini JC. Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 277: 11559-69. PMID 11756461 DOI: 10.1074/Jbc.M111698200 |
0.541 |
|
| 2001 |
Bardarov SS, Bardarov SS, Jacobs WR. Transposon mutagenesis in mycobacteria using conditionally replicating mycobacteriophages. Methods in Molecular Medicine. 54: 43-57. PMID 21341068 DOI: 10.1385/1-59259-147-7:043 |
0.331 |
|
| 2001 |
Braunstein M, Brown AM, Kurtz S, Jacobs WR. Two nonredundant SecA homologues function in mycobacteria. Journal of Bacteriology. 183: 6979-90. PMID 11717254 DOI: 10.1128/Jb.183.24.6979-6990.2001 |
0.773 |
|
| 2001 |
Brennan MJ, Delogu G, Chen Y, Bardarov S, Kriakov J, Alavi M, Jacobs WR. Evidence that Mycobacterial PE_PGRS Proteins Are Cell Surface Constituents That Influence Interactions with Other Cells Infection and Immunity. 69: 7326-7333. PMID 11705904 DOI: 10.1128/Iai.69.12.7326-7333.2001 |
0.473 |
|
| 2001 |
Raman S, Song T, Puyang X, Bardarov S, Jacobs WR, Husson RN. The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis. Journal of Bacteriology. 183: 6119-25. PMID 11567012 DOI: 10.1128/Jb.183.20.6119-6125.2001 |
0.355 |
|
| 2001 |
Glickman MS, Jacobs WR. Microbial pathogenesis of Mycobacterium tuberculosis: Dawn of a discipline Cell. 104: 477-485. PMID 11239406 DOI: 10.1016/S0092-8674(01)00236-7 |
0.62 |
|
| 2001 |
Schwebach JR, Jacobs WR, Casadevall A. Sterilization of Mycobacterium tuberculosis Erdman samples by antimicrobial fixation in a biosafety level 3 laboratory. Journal of Clinical Microbiology. 39: 769-71. PMID 11158148 DOI: 10.1128/Jcm.39.2.769-771.2001 |
0.391 |
|
| 2001 |
Glickman MS, Cahill SM, Jacobs WR. The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase Journal of Biological Chemistry. 276: 2228-2233. PMID 11092877 DOI: 10.1074/Jbc.C000652200 |
0.644 |
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| 2000 |
Chambers MA, Williams A, Gavier-Widén D, Whelan A, Hall G, Marsh PD, Bloom BR, Jacobs WR, Hewinson RG. Identification of a Mycobacterium bovis BCG auxotrophic mutant that protects guinea pigs against M. bovis and hematogenous spread of Mycobacterium tuberculosis without sensitization to tuberculin. Infection and Immunity. 68: 7094-9. PMID 11083835 DOI: 10.1128/Iai.68.12.7094-7099.2000 |
0.448 |
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| 2000 |
Zimhony O, Cox JS, Welch JT, Vilchèze C, Jacobs WR. Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis. Nature Medicine. 6: 1043-7. PMID 10973326 DOI: 10.1038/79558 |
0.715 |
|
| 2000 |
McKinney JD, Höner zu Bentrup K, Muñoz-Elías EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR, Russell DG. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature. 406: 735-8. PMID 10963599 DOI: 10.1038/35021074 |
0.447 |
|
| 2000 |
Glickman MS, Cox JS, Jacobs WR. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Molecular Cell. 5: 717-27. PMID 10882107 DOI: 10.1016/S1097-2765(00)80250-6 |
0.771 |
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| 2000 |
Vilchèze C, Morbidoni HR, Weisbrod TR, Iwamoto H, Kuo M, Sacchettini JC, Jacobs WR. Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis. Journal of Bacteriology. 182: 4059-4067. PMID 10869086 DOI: 10.1128/Jb.182.14.4059-4067.2000 |
0.37 |
|
| 2000 |
Braunstein M, Griffin TJ IV, Kriakov JI, Friedman ST, Grindley ND, Jacobs WR. Identification of genes encoding exported Mycobacterium tuberculosis proteins using a Tn552'phoA in vitro transposition system. Journal of Bacteriology. 182: 2732-40. PMID 10781540 DOI: 10.1128/Jb.182.10.2732-2740.2000 |
0.662 |
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| 2000 |
Hondalus MK, Bardarov S, Russell R, Chan J, Jacobs WR, Bloom BR. Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis Infection and Immunity. 68: 2888-2898. PMID 10768986 DOI: 10.1128/Iai.68.5.2888-2898.2000 |
0.498 |
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| 2000 |
Kremer L, Douglas JD, Baulard AR, Morehouse C, Guy MR, Alland D, Dover LG, Lakey JH, Jacobs WR, Brennan PJ, Minnikin DE, Besra GS. Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis. The Journal of Biological Chemistry. 275: 16857-64. PMID 10747933 DOI: 10.1074/Jbc.M000569200 |
0.443 |
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| 2000 |
Alland D, Steyn AJ, Weisbrod T, Aldrich K, Jacobs WR. Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition. Journal of Bacteriology. 182: 1802-11. PMID 10714983 DOI: 10.1128/Jb.182.7.1802-1811.2000 |
0.416 |
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| 2000 |
Piatek AS, Telenti A, Murray MR, El-Hajj H, Jacobs WR, Kramer FR, Alland D. Genotypic analysis of Mycobacterium tuberculosis in two distinct populations using molecular beacons: implications for rapid susceptibility testing. Antimicrobial Agents and Chemotherapy. 44: 103-10. PMID 10602730 DOI: 10.1128/Aac.44.1.103-110.2000 |
0.361 |
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| 1999 |
Bange F-, Collins FM, Jacobs WR. Survival of mice infected with Mycobacterium smegmatis containing large DNA fragments from Mycobacterium tuberculosis. Tubercle and Lung Disease. 79: 171-180. PMID 10656115 DOI: 10.1054/Tuld.1998.0201 |
0.494 |
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| 1999 |
Cox JS, Chen B, McNeil M, Jacobs WR. Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature. 402: 79-83. PMID 10573420 DOI: 10.1038/47042 |
0.725 |
|
| 1999 |
Pavelka MS, Jacobs WR. Comparison of the construction of unmarked deletion mutations in Mycobacterium smegmatis, Mycobacterium bovis bacillus Calmette-Guérin, and Mycobacterium tuberculosis H37Rv by allelic exchange. Journal of Bacteriology. 181: 4780-9. PMID 10438745 DOI: 10.1128/Jb.181.16.4780-4789.1999 |
0.5 |
|
| 1999 |
Dussurget O, Timm J, Gomez M, Gold B, Yu S, Sabol SZ, Holmes RK, Jacobs WR, Smith I. Transcriptional control of the iron-responsive fxbA gene by the mycobacterial regulator IdeR Journal of Bacteriology. 181: 3402-3408. PMID 10348851 DOI: 10.1128/Jb.181.11.3402-3408.1999 |
0.336 |
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| 1999 |
Riska PF, Su Y, Bardarov S, Freundlich L, Sarkis G, Hatfull G, Carrière C, Kumar V, Chan J, Jacobs WR. Rapid film-based determination of antibiotic susceptibilities of Mycobacterium tuberculosis strains by using a luciferase reporter phage and the Bronx Box Journal of Clinical Microbiology. 37: 1144-1149. PMID 10074539 DOI: 10.1128/Jcm.37.4.1144-1149.1999 |
0.429 |
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| 1999 |
Riska PF, Su Y, Bardarov S, Freundlich L, Sarkis G, Hatfull G, Carrière C, Kumar V, Chan J, Jacobs WR. Rapid Film-Based Determination of Antibiotic Susceptibilities ofMycobacterium tuberculosis Strains by Using a Luciferase Reporter Phage and the Bronx Box Journal of Clinical Microbiology. 37: 1144-1149. DOI: 10.1128/jcm.37.4.1144-1149.1999 |
0.313 |
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| 1998 |
Banerjee A, Sugantino M, Sacchettini JC, Jacobs WR. The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance. Microbiology. 144: 2697-2704. PMID 9802011 DOI: 10.1099/00221287-144-10-2697 |
0.512 |
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| 1998 |
Alland D, Kramnik I, Weisbrod TR, Otsubo L, Cerny R, Miller LP, Jacobs WR, Bloom BR. Identification of differentially expressed mRNA in prokaryotic organisms by customized amplification libraries (DECAL): the effect of isoniazid on gene expression in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 95: 13227-32. PMID 9789070 DOI: 10.1073/Pnas.95.22.13227 |
0.37 |
|
| 1998 |
Basso LA, Zheng R, Musser JM, Jacobs WR, Blanchard JS. Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates. The Journal of Infectious Diseases. 178: 769-75. PMID 9728546 DOI: 10.1086/515362 |
0.387 |
|
| 1998 |
Yu S, Fiss E, Jacobs WR. Analysis of the exochelin locus in Mycobacterium smegmatis: biosynthesis genes have homology with genes of the peptide synthetase family. Journal of Bacteriology. 180: 4676-4685. PMID 9721311 DOI: 10.1128/Jb.180.17.4676-4685.1998 |
0.362 |
|
| 1998 |
Rozwarski DA, Grant GA, Barton DH, Jacobs WR, Sacchettini JC. Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis. Science (New York, N.Y.). 279: 98-102. PMID 9417034 DOI: 10.1126/Science.279.5347.98 |
0.372 |
|
| 1998 |
Miesel L, Weisbrod TR, Marcinkeviciene JA, Bittman R, Jacobs WR. NADH Dehydrogenase Defects Confer Isoniazid Resistance and Conditional Lethality in Mycobacterium smegmatis Journal of Bacteriology. 180: 2459-2467. DOI: 10.1128/Jb.180.9.2459-2467.1998 |
0.428 |
|
| 1998 |
Mckinney JD, Jacobs WR, Bloom BR. 3 Persisting problems in tuberculosis Biomedical Research Reports. 1: 51-146. DOI: 10.1016/S1874-5326(07)80027-5 |
0.436 |
|
| 1997 |
Carrière C, Riska PF, Zimhony O, Kriakov J, Bardarov S, Burns J, Chan J, Jacobs WR. Conditionally replicating luciferase reporter phages: Improved sensitivity for rapid detection and assessment of drug susceptibility of Mycobacterium tuberculosis Journal of Clinical Microbiology. 35: 3232-3239. PMID 9399525 DOI: 10.1128/Jcm.35.12.3232-3239.1997 |
0.419 |
|
| 1997 |
Riska PF, Jacobs WR, Bloom BR, Mckitrick J, Chan J. Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: Use of p-nitro-α-acetylamino-β- hydroxy propiophenone Journal of Clinical Microbiology. 35: 3225-3231. PMID 9399524 DOI: 10.1128/Jcm.35.12.3225-3231.1997 |
0.476 |
|
| 1997 |
Bardarov S, Kriakov J, Carriere C, Yu S, Vaamonde C, Mcadam RA, Bloom BR, Hatfull GF, Jacobs WR. Conditionally replicating mycobacteriophages: A system for transposon delivery to Mycobacterium tuberculosis Proceedings of the National Academy of Sciences of the United States of America. 94: 10961-10966. PMID 9380742 DOI: 10.1073/Pnas.94.20.10961 |
0.464 |
|
| 1997 |
Pelicic V, Jackson M, Reyrat JM, Jacobs WR, Gicquel B, Guilhot C. Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 10955-60. PMID 9380741 DOI: 10.1073/Pnas.94.20.10955 |
0.442 |
|
| 1997 |
Telenti A, Southworth M, Alcaide F, Daugelat S, Jacobs WR, Perler FB. The Mycobacterium xenopi GyrA protein splicing element: characterization of a minimal intein. Journal of Bacteriology. 179: 6378-6382. PMID 9335286 DOI: 10.1128/Jb.179.20.6378-6382.1997 |
0.347 |
|
| 1997 |
Sreevatsan S, Stockbauer KE, Pan X, Kreiswirth BN, Moghazeh SL, Jacobs WR, Telenti A, Musser JM. Ethambutol resistance in Mycobacterium tuberculosis: Critical role of embB mutations Antimicrobial Agents and Chemotherapy. 41: 1677-1681. PMID 9257740 DOI: 10.1128/Aac.41.8.1677 |
0.4 |
|
| 1997 |
Telenti A, Philipp WJ, Sreevatsan S, Bernasconi C, Stockbauer KE, Wieles B, Musser JM, Jacobs WR. The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol. Nature Medicine. 3: 567-70. PMID 9142129 DOI: 10.1038/Nm0597-567 |
0.442 |
|
| 1997 |
Pavelka MS, Weisbrod TR, Jacobs WR. Cloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosis. Journal of Bacteriology. 179: 2777-82. PMID 9098082 DOI: 10.1128/Jb.179.8.2777-2782.1997 |
0.409 |
|
| 1997 |
Tuckman D, Donnelly RJ, Zhao FX, Jacobs WR, Connell ND. Interruption of the phosphoglucose isomerase gene results in glucose auxotrophy in Mycobacterium smegmatis. Journal of Bacteriology. 179: 2724-30. PMID 9098072 DOI: 10.1128/Jb.179.8.2724-2730.1997 |
0.34 |
|
| 1997 |
Pavelka MS, Jacobs WR. Biosynthesis of diaminopimelate, the precursor of lysine and a component of peptidoglycan, is an essential function of Mycobacterium smegmatis. Journal of Bacteriology. 178: 6496-507. PMID 8932306 DOI: 10.1128/Jb.178.22.6496-6507.1996 |
0.406 |
|
| 1996 |
Pearson RE, Jurgensen S, Sarkis GJ, Hatfull GF, Jacobs WR. Construction of D29 shuttle phasmids and luciferase reporter phages for detection of mycobacteria. Gene. 183: 129-36. PMID 8996097 DOI: 10.1016/S0378-1119(96)00530-6 |
0.367 |
|
| 1996 |
Hewinson RG, Michell SL, Russell WP, Mcadam RA, Jacobs WR. Molecular Characterization of MPT83: a Seroreactive Antigen of Mycobacterium tuberculosis with Homology to MPT70 Scandinavian Journal of Immunology. 43: 490-499. PMID 8633206 DOI: 10.1046/J.1365-3083.1996.D01-78.X |
0.477 |
|
| 1996 |
Bange FC, Brown AM, Jacobs WR. Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages. Infection and Immunity. 64: 1794-1799. PMID 8613393 DOI: 10.1128/Iai.64.5.1794-1799.1996 |
0.366 |
|
| 1996 |
Guleria I, Teitelbaum R, McAdam RA, Kalpana G, Jacobs WR, Bloom BR. Auxotrophic vaccines for tuberculosis. Nature Medicine. 2: 334-7. PMID 8612234 DOI: 10.1038/Nm0396-334 |
0.402 |
|
| 1996 |
Takiff HE, Cimino M, Musso MC, Weisbrod T, Martinez R, Delgado MB, Salazar L, Bloom BR, Jacobs WR. Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis. Proceedings of the National Academy of Sciences of the United States of America. 93: 362-6. PMID 8552639 DOI: 10.1073/Pnas.93.1.362 |
0.397 |
|
| 1996 |
Balasubramanian V, Pavelka MS, Bardarov SS, Martin J, Weisbrod TR, McAdam RA, Bloom BR, Jacobs WR. Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates. Journal of Bacteriology. 178: 273-9. PMID 8550428 DOI: 10.1128/Jb.178.1.273-279.1996 |
0.483 |
|
| 1995 |
Dessen A, Quémard A, Blanchard JS, Jacobs WR, Sacchettini JC. Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis Science. 267: 1638-1641. PMID 7886450 DOI: 10.1126/Science.7886450 |
0.397 |
|
| 1995 |
McAdam RA, Weisbrod TR, Martin J, Scuderi JD, Brown AM, Cirillo JD, Bloom BR, Jacobs WR. In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis Infection and Immunity. 63: 1004-1012. PMID 7868221 DOI: 10.1128/Iai.63.3.1004-1012.1995 |
0.435 |
|
| 1995 |
Cirillo JD, Stover CK, Bloom BR, Jacobs WR, Barletta RG. Bacterial vaccine vectors and bacillus calmette-guérin Clinical Infectious Diseases. 20: 1001-1009. PMID 7795044 DOI: 10.1093/Clinids/20.4.1001 |
0.341 |
|
| 1995 |
Falcone V, Bassey E, Jacobs W, Collins F. The immunogenicity of recombinant Mycobacterium smegmatis bearing BCG genes. Microbiology. 141: 1239-1245. PMID 7773417 DOI: 10.1099/13500872-141-5-1239 |
0.378 |
|
| 1995 |
Collins DM, Kawakami RP, de Lisle GW, Pascopella L, Bloom BR, Jacobs WR. Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex. Proceedings of the National Academy of Sciences of the United States of America. 92: 8036-40. PMID 7644534 DOI: 10.1073/Pnas.92.17.8036 |
0.393 |
|
| 1995 |
Sarkis GJ, Jacobs WR, Hatfull GF. L5 luciferase reporter mycobacteriophages: A sensitive tool for the detection and assay of live mycobacteria Molecular Microbiology. 15: 1055-1067. PMID 7623662 DOI: 10.1111/J.1365-2958.1995.Tb02281.X |
0.408 |
|
| 1995 |
Quémard A, Dessen A, Sacchettini J, Jacobs W, Blanchard J. 069-PA11 Caractérisation de la cible moléculaire de l'isoniazide chez M. tuberculosis Tubercle and Lung Disease. 76: 83-84. DOI: 10.1016/0962-8479(95)90321-6 |
0.385 |
|
| 1994 |
Banerjee A, Dubnau E, Quemard A, Balasubramanian V, Um KS, Wilson T, Collins D, de Lisle G, Jacobs WR. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science (New York, N.Y.). 263: 227-30. PMID 8284673 DOI: 10.1126/Science.8284673 |
0.485 |
|
| 1994 |
Pascopella L, Collins FM, Martin JM, Mong Hong Lee, Hatfull GF, Stover CK, Bloom BR, Jacobs WR. Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence Infection and Immunity. 62: 1313-1319. PMID 8132338 DOI: 10.1128/Iai.62.4.1313-1319.1994 |
0.452 |
|
| 1994 |
Mills JA, McNeil MR, Belisle JT, Jacobs WR, Brennan PJ. Loci of Mycobacterium avium ser2 gene cluster and their functions Journal of Bacteriology. 176: 4803-4808. PMID 8050992 DOI: 10.1128/Jb.176.16.4803-4808.1994 |
0.349 |
|
| 1994 |
Takiff HE, Salazar L, Guerrero C, Philipp W, Huang WM, Kreiswirth B, Cole ST, Jacobs WR, Telenti A. Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations. Antimicrobial Agents and Chemotherapy. 38: 773-80. PMID 8031045 DOI: 10.1128/Aac.38.4.773 |
0.417 |
|
| 1994 |
Cirillo JD, Weisbrod TR, Banerjee A, Bloom BR, Jacobs WR. Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria. Journal of Bacteriology. 176: 4424-9. PMID 8021227 DOI: 10.1128/Jb.176.14.4424-4429.1994 |
0.388 |
|
| 1994 |
Heym B, Honoré N, Schurra C, Cole ST, Truffot-Pernot C, Grosset JH, Banerjee A, Jacobs WR, Embden JDAv. Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: A molecular study The Lancet. 344: 293-298. PMID 7914261 DOI: 10.1016/S0140-6736(94)91338-2 |
0.382 |
|
| 1994 |
Cirillo JD, Weisbrod TR, Pascopella L, Bloom BR, Jacobs WR. Isolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteria Molecular Microbiology. 11: 629-639. PMID 7910936 DOI: 10.1111/J.1365-2958.1994.Tb00342.X |
0.398 |
|
| 1994 |
Bloom BR, Jacobs WR, Clark-Curtiss JE. Leprosy vaccine. Nature. 368: 579. PMID 7908414 DOI: 10.1038/368579c0 |
0.627 |
|
| 1994 |
Fiss EH, Yu S, Jacobs WR. Identification of genes involved in the sequestration of iron in mycobacteria: the ferric exochelin biosynthetic and uptake pathways Molecular Microbiology. 14: 557-569. PMID 7885234 DOI: 10.1111/J.1365-2958.1994.Tb02189.X |
0.407 |
|
| 1994 |
Collins F, Falcone V, Jacobs W. Immunogenicity of mycobacterium smegmatis recombinants bearing BCG genes in susceptible and resistant MICE Tubercle and Lung Disease. 75: 30-31. DOI: 10.1016/0962-8479(94)90793-5 |
0.358 |
|
| 1993 |
Jacobs WR, Barletta RG, Udani R, Chan J, Kalkut G, Sosne G, Kieser T, Sarkis GJ, Hatfull GF, Bloom BR. Rapid assessment of drug susceptibilities of mycobacterium tuberculosis by means of luciferase reporter phages Science. 260: 819-822. PMID 8484123 DOI: 10.1126/Science.8484123 |
0.45 |
|
| 1993 |
Donnelly-Wu MK, Jacobs WR, Hatfull GF. Superinfection immunity of mycobacteriophage L5: Applications for genetic transformation of mycobacteria Molecular Microbiology. 7: 407-417. PMID 8459767 DOI: 10.1111/J.1365-2958.1993.Tb01132.X |
0.35 |
|
| 1993 |
Ellner JJ, Hinman AR, Dooley SW, Fischl MA, Sepkowitz KA, Goldberger MJ, Shinnick TM, Iseman MD, Jacobs WR. Tuberculosis Symposium: Emerging Problems and Promise Journal of Infectious Diseases. 168: 537-551. PMID 8354898 DOI: 10.1093/Infdis/168.3.537 |
0.414 |
|
| 1993 |
Cooksey RC, Crawford JT, Jacobs WR, Shinnick TM. A rapid method for screening antimicrobial agents for activities against a strain of Mycobacterium tuberculosis expressing firefly luciferase Antimicrobial Agents and Chemotherapy. 37: 1348-1352. PMID 8328785 DOI: 10.1128/Aac.37.6.1348 |
0.436 |
|
| 1993 |
Averill LE, Cavallo U, Wallis RS, Boom WH, Bona M, Mincek M, Pascopella L, Jacobs WR, Ellner JJ. Screening of a cosmid library of Mycobacterium bovis BCG in Mycobacterium smegmatis for novel T-cell stimulatory antigens. Research in Microbiology. 144: 349-62. PMID 8248628 DOI: 10.1016/0923-2508(93)90192-5 |
0.366 |
|
| 1992 |
Jacobs WR. Advances in mycobacterial genetics: new promises for old diseases. Immunobiology. 184: 147-156. PMID 1587540 DOI: 10.1016/S0171-2985(11)80472-9 |
0.44 |
|
| 1992 |
Connell N, Stover CK, Jacobs WR. Old microbes with new faces: molecular biology and the design of new vaccines. Current Opinion in Immunology. 4: 442-448. PMID 1388846 DOI: 10.1016/S0952-7915(06)80036-1 |
0.318 |
|
| 1992 |
Daley CL, Small PM, Schecter GF, Schoolnik GK, McAdam RA, Jacobs WR, Hopewell PC. An Outbreak of Tuberculosis With Accelerated Progression Among Persons Infected With the Human Immunodeficiency Virus. An Analysis Using Restriction-Fragment-Length Polymorphisms The New England Journal of Medicine. 326: 231-235. PMID 1345800 DOI: 10.1056/Nejm199201233260404 |
0.388 |
|
| 1991 |
Kalpana GV, Bloom BR, Jacobs WR. Insertional mutagenesis and illegitimate recombination in mycobacteria Proceedings of the National Academy of Sciences of the United States of America. 88: 5433-5437. PMID 2052623 DOI: 10.1073/Pnas.88.12.5433 |
0.506 |
|
| 1991 |
Sirawaraporn W, Sirawaraporn R, Chanpongsri A, Jacobs WR, Santi DV. Purification and characterization of dihydrofolate reductase from wild-type and trimethoprim-resistant Mycobacterium smegmatis. Experimental Parasitology. 72: 184-90. PMID 2009922 DOI: 10.1016/0014-4894(91)90136-K |
0.335 |
|
| 1991 |
Belisle JT, Pascopella L, Inamine JM, Brennan PJ, Jacobs WR. Isolation and expression of a gene cluster responsible for biosynthesis of the glycopeptidolipid antigens of Mycobacterium avium Journal of Bacteriology. 173: 6991-6997. PMID 1938900 DOI: 10.1128/Jb.173.21.6991-6997.1991 |
0.307 |
|
| 1991 |
Stover CK, De La Cruz VF, Fuerst TR, Burlein JE, Benson LA, Bennett LT, Bansal GP, Young JF, Lee MH, Hatfull GF, Snapper SB, Barletta RG, Jacobs WR, Bloom BR. New use of BCG for recombinant vaccines Nature. 351: 456-460. PMID 1904554 DOI: 10.1038/351456A0 |
0.357 |
|
| 1991 |
Jacobs WR, Kalpana GV, Cirillo JD, Pascopella L, Snapper SB, Udani RA, Jones W, Barletta RG, Bloom BR. Genetic systems for mycobacteria Methods in Enzymology. 204: 537-555. PMID 1658570 DOI: 10.1016/0076-6879(91)04027-L |
0.356 |
|
| 1990 |
Lugosi L, Jacobs WR, Bloom BR. Genetic transformation of BCG. Tubercle. 70: 159-70. PMID 2694552 DOI: 10.1016/0041-3879(89)90046-9 |
0.339 |
|
| 1990 |
Bloom BR, Jacobs WR. New strategies for leprosy and tuberculosis and for development of bacillus Calmette-Guérin into a multivaccine vehicle. Annals of the New York Academy of Sciences. 569: 155-73. PMID 2516995 DOI: 10.1111/J.1749-6632.1989.Tb27366.X |
0.368 |
|
| 1990 |
Jacobs WR, Snapper SB, Lugosi L, Bloom BR. Development of BCG as a recombinant vaccine vehicle. Current Topics in Microbiology and Immunology. 155: 153-60. PMID 2407431 DOI: 10.1007/978-3-642-74983-4_11 |
0.428 |
|
| 1990 |
Barletta RG, Snapper B, Cirillo JD, Connell ND, Kim DD, Jacobs WR, Bloom BR. Recombinant BCG as a candidate oral vaccine vector Research in Microbiology. 141: 931-939. PMID 2101484 DOI: 10.1016/0923-2508(90)90132-A |
0.357 |
|
| 1990 |
Snapper SB, Melton RE, Mustafa S, Kieser T, Jacobs WR. Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Molecular Microbiology. 4: 1911-1919. PMID 2082148 DOI: 10.1111/J.1365-2958.1990.Tb02040.X |
0.366 |
|
| 1989 |
Jacobs WR, Snapper SB, Tuckman M, Bloom BR. Mycobacteriophage vector systems. Reviews of Infectious Diseases. S404-10. PMID 2652256 DOI: 10.1093/Clinids/11.Supplement_2.S404 |
0.325 |
|
| 1989 |
Grosskinsky CM, Jacobs WR, Clark-Curtiss JE, Bloom BR. Genetic relationships among Mycobacterium leprae, Mycobacterium tuberculosis, and candidate leprosy vaccine strains determined by DNA hybridization: identification of an M. leprae-specific repetitive sequence. Infection and Immunity. 57: 1535-1541. DOI: 10.1128/Iai.57.5.1535-1541.1989 |
0.721 |
|
| 1988 |
Snapper SB, Lugosi L, Jekkel A, Melton RE, Kieser T, Bloom BR, Jacobs WR. Lysogeny and transformation in mycobacteria: stable expression of foreign genes. Proceedings of the National Academy of Sciences of the United States of America. 85: 6987-91. PMID 2842799 DOI: 10.1073/Pnas.85.18.6987 |
0.422 |
|
| 1987 |
Jacobs WR, Tuckman M, Bloom BR. Introduction of foreign DNA into mycobacteria using a shuttle phasmid. Nature. 327: 532-5. PMID 3473289 DOI: 10.1038/327532A0 |
0.484 |
|
| 1986 |
Jacobs WR, Barrett JF, Clark-Curtiss JE, Curtiss rR. In vivo repackaging of recombinant cosmid molecules for analyses of Salmonella typhimurium, Streptococcus mutans, and mycobacterial genomic libraries. Infection and Immunity. 52: 101-109. PMID 2937735 DOI: 10.1128/Iai.52.1.101-109.1986 |
0.69 |
|
| 1986 |
Jacobs WR, Docherty MA, Curtiss R, Clark-Curtiss JE. Expression of Mycobacterium leprae genes from a Streptococcus mutans promoter in Escherichia coli K-12. Proceedings of the National Academy of Sciences of the United States of America. 83: 1926-1930. PMID 2869492 DOI: 10.1073/Pnas.83.6.1926 |
0.743 |
|
| 1985 |
Clark-Curtiss JE, Jacobs WR, Docherty MA, Ritchie LR, Curtiss R. Molecular analysis of DNA and construction of genomic libraries of Mycobacterium leprae. Journal of Bacteriology. 161: 1093-102. PMID 3882664 DOI: 10.1128/Jb.161.3.1093-1102.1985 |
0.694 |
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