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Adam R Offenbacher, Ph.D. - Publications

Affiliations: 
2013 Chemistry and Biochemistry Georgia Institute of Technology, Atlanta, GA 
 2013-2017 Chemistry University of California, Berkeley, Berkeley, CA, United States 
 2017- Biochemistry East Carolina University, Greenville, NC, United States 
Website:
http://www.ecu.edu/cs-cas/chem/Adam-Offenbacher.cfm
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Guevara L, Gouge M, Ohler A, Hill SG, Patel S, Offenbacher AR. Effect of solvent viscosity on the activation barrier of hydrogen tunneling in the lipoxygenase reaction. Archives of Biochemistry and Biophysics. 747: 109740. PMID 37678425 DOI: 10.1016/j.abb.2023.109740  0.772
2023 Sharma A, Whittington C, Jabed M, Hill SG, Kostenko A, Yu T, Li P, Doan PE, Hoffman BM, Offenbacher AR. C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme-Substrate Complex of an Active, -Linked Glycosylated Lipoxygenase. Biochemistry. PMID 37115010 DOI: 10.1021/acs.biochem.3c00119  0.772
2023 Zaragoza JPT, Offenbacher AR, Hu S, Gee CL, Firestein ZM, Minnetian N, Deng Z, Fan F, Iavarone AT, Klinman JP. Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase. Proceedings of the National Academy of Sciences of the United States of America. 120: e2211630120. PMID 36867685 DOI: 10.1073/pnas.2211630120  0.824
2023 Pinelo JEE, Manandhar P, Popovic G, Ray K, Tasdelen MF, Nguyen Q, Iavarone AT, Offenbacher AR, Hudson NE, Sen M. Systematic mapping of the conformational landscape and dynamism of soluble fibrinogen. Journal of Thrombosis and Haemostasis : Jth. PMID 36746319 DOI: 10.1016/j.jtha.2023.01.034  0.752
2022 Tyson K, Tangtartharakul CB, Zeug M, Findling N, Haddy A, Hvastkovs E, Choe JY, Kim JE, Offenbacher AR. Electrochemical and Structural Study of the Buried Tryptophan in Azurin: Effects of Hydration and Polarity on the Redox Potential of W48. The Journal of Physical Chemistry. B. PMID 36542812 DOI: 10.1021/acs.jpcb.2c06677  0.772
2022 Tran M, Signorelli RL, Yamaguchi A, Chen E, Hollinstat M, Iavarone AT, Offenbacher AR, Holman T. Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder. Archives of Biochemistry and Biophysics. 109472. PMID 36442529 DOI: 10.1016/j.abb.2022.109472  0.777
2022 Labrecque CL, Nolan AL, Develin AM, Castillo AJ, Offenbacher AR, Fuglestad B. Membrane-Mimicking Reverse Micelles for High-Resolution Interfacial Study of Proteins and Membranes. Langmuir : the Acs Journal of Surfaces and Colloids. 38: 3676-3686. PMID 35298177 DOI: 10.1021/acs.langmuir.1c03085  0.299
2022 Popovic G, Kirby NC, Dement TC, Peterson KM, Daub CE, Belcher HA, Guthold M, Offenbacher AR, Hudson NE. Development of Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen. International Journal of Molecular Sciences. 23. PMID 35162976 DOI: 10.3390/ijms23031054  0.732
2022 Roberts DE, Benton AM, Fabian-Bayola C, Spuches AM, Offenbacher AR. Thermodynamic and biophysical study of fatty acid effector binding to soybean lipoxygenase: implications for allostery driven by helix α2 dynamics. Febs Letters. PMID 34997975 DOI: 10.1002/1873-3468.14275  0.726
2021 Safiarian MS, Watson RA, Lieberman RL, Barry BA, Offenbacher AR. Ribonucleotide Reductase β2 Subunit Inactivation by Triapine Occurs through Binding of a Triapine-Fe(II) Adduct. The Journal of Physical Chemistry Letters. 9020-9025. PMID 34516127 DOI: 10.1021/acs.jpclett.1c02103  0.599
2021 Tsai WC, Gilbert NC, Ohler A, Armstrong M, Perry S, Kalyanaraman C, Yasgar A, Rai G, Simeonov A, Jadhav A, Standley M, Lee HW, Crews P, Iavarone AT, Jacobson MP, ... ... Offenbacher AR, et al. Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2. Bioorganic & Medicinal Chemistry. 46: 116349. PMID 34500187 DOI: 10.1016/j.bmc.2021.116349  0.76
2021 Watson RA, Offenbacher AR, Barry BA. Detection of Catalytically Linked Conformational Changes in Wild-Type Class Ia Ribonucleotide Reductase Using Reaction-Induced FTIR Spectroscopy. The Journal of Physical Chemistry. B. PMID 34289692 DOI: 10.1021/acs.jpcb.1c03038  0.669
2021 Tsai WC, Aleem AM, Whittington C, Cortopassi WA, Kalyanaraman C, Baroz A, Iavarone AT, Skrzypczak-Jankun E, Jacobson MP, Offenbacher AR, Holman T. Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase. Biochemistry. PMID 33635645 DOI: 10.1021/acs.biochem.1c00053  0.801
2021 Ohler A, Long H, Ohgo K, Tyson K, Murray D, Davis A, Whittington C, Hvastkovs EG, Duffy L, Haddy A, Sargent AL, Allen WE, Offenbacher AR. Synthesis of redox-active fluorinated 5-hydroxytryptophans as molecular reporters for biological electron transfer. Chemical Communications (Cambridge, England). PMID 33626126 DOI: 10.1039/d1cc00187f  0.672
2020 Offenbacher AR, Holman TR. Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases. Molecules (Basel, Switzerland). 25. PMID 32722330 DOI: 10.3390/Molecules25153374  0.464
2020 Tyson KJ, Davis AN, Norris JL, Bartolotti LJ, Hvastkovs EG, Offenbacher AR. Impact of Local Electrostatics on the Redox Properties of Tryptophan Radicals in Azurin: Implications for Redox-Active Tryptophans in Proton-Coupled Electron Transfer. The Journal of Physical Chemistry Letters. PMID 32134666 DOI: 10.1021/Acs.Jpclett.0C00614  0.784
2020 Offenbacher AR, Sharma A, Doan PE, Klinman JP, Hoffman BM. The Soybean Lipoxygenase-Substrate Complex: Correlation between the Properties of Tunneling-Ready States and ENDOR-Detected Structures of Ground States. Biochemistry. PMID 32022556 DOI: 10.1021/Acs.Biochem.9B00861  0.652
2020 Offenbacher AR, Barry BA. A Proton Wire Mediates Proton Coupled Electron Transfer from Hydroxyurea and Other Hydroxamic Acids to Tyrosyl Radical in Class Ia Ribonucleotide Reductase. The Journal of Physical Chemistry. B. PMID 31904962 DOI: 10.1021/Acs.Jpcb.9B08587  0.687
2019 Hu S, Offenbacher AR, Lu ED, Klinman JP. Comparative kinetic isotope effects on first- and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network. The Journal of Biological Chemistry. PMID 31624150 DOI: 10.1074/Jbc.Ra119.010826  0.806
2019 Zaragoza JPT, Nguy A, Minnetian N, Deng Z, Iavarone AT, Offenbacher AR, Klinman JP. Detecting and Characterizing the Kinetic Activation of Thermal Networks in Proteins: Thermal Transfer from a Distal, Solvent-Exposed Loop to the Active Site in Soybean Lipoxygenase. The Journal of Physical Chemistry. B. PMID 31580070 DOI: 10.1021/Acs.Jpcb.9B07228  0.667
2019 Kostenko A, Ray K, Iavarone AT, Offenbacher AR. Kinetic characterization of the C-H activation step for the lipoxygenase from the pathogenic fungus, M. oryzae: Impact of N-linked glycosylation. Biochemistry. PMID 31264852 DOI: 10.1021/Acs.Biochem.9B00467  0.812
2019 Hu S, Offenbacher AR, Thompson EM, Gee CL, Wilcoxen J, Carr CAM, Prigozhin DM, Yang V, Alber T, Britt RD, Fraser JS, Klinman JP. Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network. Journal of the American Chemical Society. PMID 30645119 DOI: 10.1021/Jacs.8B10992  0.816
2018 Klinman JP, Offenbacher AR. Understanding Biological Hydrogen Transfer Through the Lens of Temperature Dependent Kinetic Isotope Effects. Accounts of Chemical Research. PMID 30152685 DOI: 10.1021/Acs.Accounts.8B00226  0.653
2017 Klinman JP, Offenbacher AR, Hu S. Origins of Enzyme Catalysis: Experimental Findings for C-H Activation, New Models, and Their Relevance to Prevailing Theoretical Constructs. Journal of the American Chemical Society. PMID 29244501 DOI: 10.1021/Jacs.7B08418  0.808
2017 Offenbacher AR, Iavarone AT, Klinman JP. Hydrogen-deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase. The Journal of Biological Chemistry. PMID 29191828 DOI: 10.1074/Jbc.M117.817197  0.655
2017 Offenbacher AR, Hu S, Poss EM, Carr CAM, Scouras AD, Prigozhin DM, Iavarone AT, Palla A, Alber T, Fraser JS, Klinman JP. Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling. Acs Central Science. 3: 570-579. PMID 28691068 DOI: 10.1021/Acscentsci.7B00142  0.828
2017 Horitani M, Offenbacher AR, Carr CA, Yu T, Hoeke V, Cutsail GE, Hammes-Schiffer S, Klinman JP, Hoffman BM. (13)C ENDOR Spectroscopy of Lipoxygenase-Substrate Complexes Reveals the Structural Basis for C-H Activation by Tunneling. Journal of the American Chemical Society. PMID 28121140 DOI: 10.1021/Jacs.6B11856  0.778
2016 Offenbacher AR, Zhu H, Klinman JP. Synthesis of Site-Specifically (13)C Labeled Linoleic Acids. Tetrahedron Letters. 57: 4537-4540. PMID 28260819 DOI: 10.1016/J.Tetlet.2016.08.071  0.595
2016 Offenbacher AR, Zhu H, Klinman JP. Synthesis of site-specifically 13C labeled linoleic acids Tetrahedron Letters. 57: 4537-4540. DOI: 10.1016/j.tetlet.2016.08.071  0.54
2014 Offenbacher AR, Watson RA, Pagba CV, Barry BA. Redox-dependent structural coupling between the α2 and β2 subunits in E. coli ribonucleotide reductase. The Journal of Physical Chemistry. B. 118: 2993-3004. PMID 24606240 DOI: 10.1021/Jp501121D  0.648
2014 Offenbacher AR, Pagba CV, Polander BC, Brahmachari U, Barry BA. First site-specific incorporation of a noncanonical amino acid into the photosynthetic oxygen-evolving complex. Acs Chemical Biology. 9: 891-6. PMID 24437616 DOI: 10.1021/Cb400880U  0.683
2014 Offenbacher AR, Polander BC, Barry BA. The Intrinsically Disordered Photosystem II Subunit, PsbO, is a Sensor for the Hydrogen Bonding Network in the Oxygen Evolving Complex Biophysical Journal. 106: 686a. DOI: 10.1016/J.Bpj.2013.11.3799  0.632
2013 Offenbacher AR, Polander BC, Barry BA. An intrinsically disordered photosystem II subunit, PsbO, provides a structural template and a sensor of the hydrogen-bonding network in photosynthetic water oxidation. The Journal of Biological Chemistry. 288: 29056-68. PMID 23940038 DOI: 10.1074/Jbc.M113.487561  0.649
2013 Offenbacher AR, Burns LA, Sherrill CD, Barry BA. Redox-linked conformational control of proton-coupled electron transfer: Y122 in the ribonucleotide reductase β2 subunit. The Journal of Physical Chemistry. B. 117: 8457-68. PMID 23822111 DOI: 10.1021/Jp404757R  0.7
2013 Offenbacher AR, Minnihan EC, Stubbe J, Barry BA. Redox-linked changes to the hydrogen-bonding network of ribonucleotide reductase β2. Journal of the American Chemical Society. 135: 6380-3. PMID 23594029 DOI: 10.1021/Ja3032949  0.657
2012 Barry BA, Chen J, Keough J, Jenson D, Offenbacher A, Pagba C. Proton Coupled Electron Transfer and Redox Active Tyrosines: Structure and Function of the Tyrosyl Radicals in Ribonucleotide Reductase and Photosystem II. The Journal of Physical Chemistry Letters. 3: 543-554. PMID 22662289 DOI: 10.1021/Jz2014117  0.661
2011 Offenbacher AR, Chen J, Barry BA. Perturbations of aromatic amino acids are associated with iron cluster assembly in ribonucleotide reductase. Journal of the American Chemical Society. 133: 6978-88. PMID 21486062 DOI: 10.1021/Ja107918G  0.654
2009 Dunn NJ, Humphries WH, Offenbacher AR, King TL, Gray JA. pH-Dependent cis --> trans isomerization rates for azobenzene dyes in aqueous solution. The Journal of Physical Chemistry. A. 113: 13144-51. PMID 19618926 DOI: 10.1021/Jp903102U  0.394
2009 Offenbacher AR, Vassiliev IR, Seyedsayamdost MR, Stubbe J, Barry BA. Redox-linked structural changes in ribonucleotide reductase. Journal of the American Chemical Society. 131: 7496-7. PMID 19489635 DOI: 10.1021/Ja901908J  0.645
2009 Offenbacher A, White KN, Sen I, Oliver AG, Konopelski JP, Barry BA, Einarsdóttir O. A spectroscopic investigation of a tridentate Cu-complex mimicking the tyrosine-histidine cross-link of cytochrome C oxidase. The Journal of Physical Chemistry. B. 113: 7407-17. PMID 19438285 DOI: 10.1021/Jp9010795  0.625
2005 Vassiliev IR, Offenbacher AR, Barry BA. Redox-active tyrosine residues in pentapeptides. The Journal of Physical Chemistry. B. 109: 23077-85. PMID 16854006 DOI: 10.1021/Jp054159F  0.647
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