Thomas A. Waldmann, M.D. - Publications

Affiliations: 
National Institutes of Health, Bethesda, MD 
Area:
Immunology and Inflammation
Website:
https://irp.nih.gov/pi/thomas-waldmann

398 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Brammer JE, Ballen K, Sokol L, Querfeld C, Nakamura R, Mishra A, Mclaughlin EM, Feith D, Azimi N, Waldmann T, Tagaya Y, Loughran T. Effective Treatment with the Selective Cytokine Inhibitor BNZ-1 Reveals the Cytokine Dependency of T-LGL Leukemia. Blood. PMID 37352612 DOI: 10.1182/blood.2022017643  0.303
2023 Sato N, Bamford RN, Bryant BR, Tagaya Y, Waldmann TA. Accessory cells precondition naïve T cells and regulatory T cells for cytokine-mediated proliferation. Proceedings of the National Academy of Sciences of the United States of America. 120: e2217562120. PMID 37014858 DOI: 10.1073/pnas.2217562120  0.342
2022 Miljkovic MD, Dubois S, Müller JR, Bryant BR, Ma E, Conlon KC, Waldmann TA. Interleukin-15 augments NK cell-mediated ADCC of alemtuzumab in patients with CD52+ T-cell malignancies. Blood Advances. PMID 35475910 DOI: 10.1182/bloodadvances.2021006440  0.362
2022 Chen W, Bamford RN, Edmondson EF, Waldmann TA. IL-15 and anti-PD-1 augment the efficacy of agonistic intratumoral anti-CD40 in a mouse model with multiple TRAMP-C2 tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 35262675 DOI: 10.1158/1078-0432.CCR-21-0496  0.308
2020 Daenthanasanmak A, Lin Y, Zhang M, Bryant BR, Petrus MN, Bamford RN, Thomas CJ, Miljkovic MD, Conlon KC, Waldmann TA. Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia. Translational Oncology. 14: 100913. PMID 33129109 DOI: 10.1016/j.tranon.2020.100913  0.313
2020 Dubois S, Waldmann TA, Müller JR. Engagement of lymphoma T cell receptors causes accelerated growth and the secretion of an NK cell-inhibitory factor. Cellular Immunology. 357: 104213. PMID 32977157 DOI: 10.1016/J.Cellimm.2020.104213  0.397
2020 Hangasky JA, Waldmann TA, Santi DV. Interleukin 15 Pharmacokinetics and Consumption by a Dynamic Cytokine Sink. Frontiers in Immunology. 11: 1813. PMID 32903632 DOI: 10.3389/Fimmu.2020.01813  0.402
2020 Traba J, Waldmann TA, Anton OM. Analysis of Human Natural Killer Cell Metabolism. Journal of Visualized Experiments : Jove. PMID 32628161 DOI: 10.3791/61466  0.358
2020 Waldmann TA, Dubois S, Miljkovic MD, Conlon KC. IL-15 in the Combination Immunotherapy of Cancer. Frontiers in Immunology. 11: 868. PMID 32508818 DOI: 10.3389/Fimmu.2020.00868  0.449
2020 Conlon KC, Sportes C, Brechbiel MW, Fowler DH, Gress R, Miljkovic MD, Chen CC, Whatley MA, Bryant BR, Corcoran EM, Kurdziel KA, Pittaluga S, Paik CH, Lee JH, Fleisher TA, ... ... Waldmann TA, et al. Y-Daclizumab (Anti-CD25), High-Dose Carmustine, Etoposide, Cytarabine, and Melphalan Chemotherapy and Autologous Hematopoietic Stem Cell Transplant Yielded Sustained Complete Remissions in 4 Patients with Recurrent Hodgkin's Lymphoma. Cancer Biotherapy & Radiopharmaceuticals. PMID 32275165 DOI: 10.1089/Cbr.2019.3298  0.384
2020 Dubois S, Feigenbaum L, Waldmann TA, Müller JR. NK cells prevent T cell lymphoma development in T cell receptor-transgenic mice. Cellular Immunology. 104081. PMID 32143838 DOI: 10.1016/J.Cellimm.2020.104081  0.443
2020 Waldmann TA, Miljkovic MD, Conlon KC. Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer. The Journal of Experimental Medicine. 217. PMID 31821442 DOI: 10.1084/Jem.20191062  0.443
2020 Miljkovic MD, Conlon KC, Albert J, Allen D, Waldmann TA. Phase 1 Study of Subcutaneous Recombinant Human (rh) Interleukin-15 and Intravenous Alemtuzumab in Patients with Rrelapsed/Refractory T-Cell Lymphoma Blood. 136: 23-24. DOI: 10.1182/blood-2020-142065  0.343
2019 Anton OM, Peterson ME, Hollander MJ, Dorward DW, Arora G, Traba J, Rajagopalan S, Snapp EL, Garcia KC, Waldmann TA, Long EO. -endocytosis of intact IL-15Rα-IL-15 complex from presenting cells into NK cells favors signaling for proliferation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31871169 DOI: 10.1073/Pnas.1911678117  0.397
2019 Ciszewski C, Discepolo V, Pacis A, Doerr N, Tastet O, Mayassi T, Maglio M, Basheer A, Al-Mawsawi LQ, Green P, Auricchio R, Troncone R, Waldmann TA, Azimi N, Tagaya Y, et al. Identification of a γc Receptor Antagonist that Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21. Gastroenterology. PMID 31622625 DOI: 10.1053/J.Gastro.2019.10.006  0.381
2019 Volkó J, Kenesei Á, Zhang M, Várnai P, Mocsár G, Petrus MN, Jambrovics K, Balajthy Z, Müller G, Bodnár A, Tóth K, Waldmann TA, Vámosi G. IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti-IL-2Rα therapies. Proceedings of the National Academy of Sciences of the United States of America. PMID 31570576 DOI: 10.1073/Pnas.1901382116  0.435
2019 Rauch DA, Conlon KC, Janakiram M, Brammer JE, Harding JC, Ye BH, Zang X, Ren X, Olson S, Cheng X, Miljkovic MD, Sundaramoorthi H, Joseph A, Skidmore ZL, Griffith O, ... ... Waldmann TA, et al. . Blood. PMID 31467059 DOI: 10.1182/Blood.2019002038  0.333
2019 Frohna PA, Ratnayake A, Doerr N, Basheer A, Al-Mawsawi LQ, Kim WJ, Zapata JC, Wu X, Waldmann TA, Azimi N, Tagaya Y. Results From a First-in-Human Study of BNZ-1, a Selective Multicytokine Inhibitor Targeting Members of the Common Gamma (γc) Family of Cytokines. Journal of Clinical Pharmacology. PMID 31465127 DOI: 10.1002/Jcph.1522  0.42
2019 Enose-Akahata Y, Oh U, Ohayon J, Billioux BJ, Massoud R, Bryant BR, Vellucci A, Ngouth N, Cortese I, Waldmann TA, Jacobson S. Clinical trial of a humanized anti-IL-2/IL-15 receptor β chain in HAM/TSP. Annals of Clinical and Translational Neurology. 6: 1383-1394. PMID 31402625 DOI: 10.1002/Acn3.50820  0.447
2019 Cooley S, He F, Bachanova V, Vercellotti GM, DeFor TE, Curtsinger JM, Robertson P, Grzywacz B, Conlon KC, Waldmann TA, McKenna DH, Blazar BR, Weisdorf DJ, Miller JS. First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia. Blood Advances. 3: 1970-1980. PMID 31266741 DOI: 10.1182/Bloodadvances.2018028332  0.402
2019 Conlon KC, Potter EL, Pittaluga S, Lee CR, Miljkovic MD, Fleisher TA, Dubois S, Bryant BR, Petrus M, Perera LP, Hsu J, Figg WD, Peer CJ, Shih JH, Yovandich JL, ... ... Waldmann TA, et al. IL-15 by continuous i.v. infusion to adult patients with solid tumors in a Phase I trial induced dramatic NK cell subset expansion. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31142503 DOI: 10.1158/1078-0432.Ccr-18-3468  0.357
2019 Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, et al. Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO1800501. PMID 30657736 DOI: 10.1200/Jco.18.00501  0.348
2019 Roswarski J, Roschewski M, Melani C, Pittaluga S, Lucas A, Steinberg SM, Jaffe ES, Waldmann TA, Wilson WH. Phase 1/2 study of alemtuzumab with dose-adjusted EPOCH in untreated aggressive T and NK cell lymphomas. Leukemia & Lymphoma. 1-5. PMID 30626252 DOI: 10.1080/10428194.2018.1562184  0.302
2019 Miljkovic MD, Conlon KC, Hsu J, Sun C, Wiestner A, Waldmann TA. Phase 1 Trial of Human IL-15 (rhIL-15) and Obinutuzumab for Relapsed and Refractory Chronic Lymphocytic Leukemia Blood. 134: 3052-3052. DOI: 10.1182/Blood-2019-130807  0.404
2019 Brammer JE, Sokol L, Tagaya Y, Rogers K, Mishra A, Waldmann TA, Azimi N, Frohna P, Ratnayake A, Loughran TP, Ballen K. Blockade of IL-15 Utilizing Bnz-1, a Selective γ-Chain Inhibiting Peptide, Is Safe and Has Clinical Activity in Patients with T-Cell Large Granular Lymphocytic Leukemia (T-LGLL): Results of a Phase I/II Multi-Center Clinical Trial Blood. 134: 2835-2835. DOI: 10.1182/Blood-2019-129291  0.384
2019 Miljkovic MD, Conlon KC, Dubois S, Hsu J, Schlom J, Gulley J, Waldmann TA. Interleukin-15 (IL-5) in Combination with Avelumab in Relapsed/Refractory Mature T-Cell Malignancies Blood. 134: 1558-1558. DOI: 10.1182/Blood-2019-128945  0.416
2019 Ishio T, Shimono J, Kumar S, Lin Y, Bachy E, Petrus MN, Yang Y, Maeda M, Goto H, Hashino S, Teshima T, Waldmann TA, Staudt L, Nakagawa M. Genome-Wide CRISPR Library Screening Identifies CDK6 As Genetic Vulnerability in Adult T-Cell Leukemia/Lymphoma Blood. 134: 3781-3781. DOI: 10.1182/Blood-2019-124670  0.382
2019 Coyne GO, Khan SS, Conlon K, Streicher H, Bruns A, Piekarz R, Takebe N, Juwara L, Parchment R, Navas T, Fino K, Fung KL, Sharon E, Doroshow JH, Waldmann TA, et al. Abstract LB-015: Phase I trial of recombinant human interleukin 15 (rhIL-15) in combination with nivolumab and ipilimumab in refractory cancers Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-Lb-015  0.365
2019 Conlon K, Leidner R, McNeel D, Gupta S, Wang-Gillam A, Waldmann TA, Pavlakis G, Dostalek M, Kurtulus S, Chowdhury NR, O'Keeffe J, Parikh NS, Thompson JA. Abstract CT082: Phase (Ph) I/Ib study of NIZ985 with and without spartalizumab (PDR001) in patients (pts) with metastatic/unresectable solid tumors Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-Ct082  0.307
2018 Nizsalóczki E, Nagy P, Mocsár G, Szabó Á, Csomós I, Waldmann TA, Vámosi G, Mátyus L, Bodnár A. Minimum degree of overlap between IL-9R and IL-2R on human T lymphoma cells: A quantitative CLSM and FRET analysis. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. PMID 30378727 DOI: 10.1002/Cyto.A.23634  0.39
2018 Zhang M, Wen B, Anton OM, Yao Z, Dubois S, Ju W, Sato N, DiLillo DJ, Bamford RN, Ravetch JV, Waldmann TA. IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages. Proceedings of the National Academy of Sciences of the United States of America. PMID 30373815 DOI: 10.1073/Pnas.1811615115  0.467
2018 Wang TT, Yang J, Zhang Y, Zhang M, Dubois S, Conlon KC, Tagaya Y, Hamele CE, Dighe S, Olson TL, Feith DJ, Azimi N, Waldmann TA, Loughran TP. IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability. Leukemia. PMID 30353031 DOI: 10.1038/S41375-018-0290-Y  0.454
2018 Nakagawa M, Shaffer AL, Ceribelli M, Zhang M, Wright G, Huang DW, Xiao W, Powell J, Petrus MN, Yang Y, Phelan JD, Kohlhammer H, Dubois SP, Yoo HM, Bachy E, ... ... Waldmann TA, et al. Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma. Cancer Cell. PMID 30057145 DOI: 10.1182/Blood.V130.Suppl_1.731.731  0.346
2018 Conlon KC, Miljkovic MD, Waldmann TA. Cytokines in the Treatment of Cancer. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. PMID 29889594 DOI: 10.1089/Jir.2018.0019  0.384
2018 Valkenburg SA, Li OTW, Li A, Bull M, Waldmann TA, Perera LP, Peiris M, Poon LLM. Protection by universal influenza vaccine is mediated by memory CD4 T cells. Vaccine. PMID 29887326 DOI: 10.1016/J.Vaccine.2018.06.007  0.32
2018 Ratner L, Waldmann TA, Janakiram M, Brammer JE. Rapid Progression of Adult T-Cell Leukemia-Lymphoma after PD-1 Inhibitor Therapy. The New England Journal of Medicine. 378: 1947-1948. PMID 29768155 DOI: 10.1056/Nejmc1803181  0.357
2018 Nagy É, Mocsár G, Sebestyén V, Volkó J, Papp F, Tóth K, Damjanovich S, Panyi G, Waldmann TA, Bodnár A, Vámosi G. Membrane Potential Distinctly Modulates Mobility and Signaling of IL-2 and -15 Receptors in T Cells. Biophysical Journal. PMID 29754714 DOI: 10.1016/J.Bpj.2018.04.038  0.385
2018 Lu L, Zhu F, Zhang M, Li Y, Drennan AC, Kimpara S, Rumball I, Selzer C, Cameron H, Kellicut A, Kelm A, Wang F, Waldmann TA, Rui L. Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 29295936 DOI: 10.1073/Pnas.1715118115  0.364
2018 O'Sullivan Coyne GH, Conlon K, Takebe N, Streicher H, Quinn MF, Bruns A, Navas T, Parchment RE, Rubinstein L, Sharon E, Doroshow JH, Waldmann TA, Chen AP. Phase I study of recombinant interleukin-15 in combination with checkpoint inhibitors nivolumab and ipilimumab in subjects with refractory cancers. Journal of Clinical Oncology. 36: TPS3128-TPS3128. DOI: 10.1200/Jco.2018.36.15_Suppl.Tps3128  0.424
2017 Miller JS, Morishima C, McNeel DG, Patel MR, Kohrt HE, Thompson JA, Sondel PM, Wakelee HA, Disis ML, Kaiser JC, Cheever MA, Streicher H, Creekmore SP, Waldmann TA, Conlon KC. A First-in-Human Phase 1 Study of Subcutaneous Outpatient Recombinant Human IL-15 (rhIL-15) in Adults with Advanced Solid Tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29203590 DOI: 10.1158/1078-0432.Ccr-17-2451  0.394
2017 Waldmann TA. Cytokines in Cancer Immunotherapy. Cold Spring Harbor Perspectives in Biology. PMID 29101107 DOI: 10.1101/Cshperspect.A028472  0.404
2017 Roswarski J, Roschewski M, Lucas A, Melani C, Pittaluga S, Jaffe ES, Steinberg SM, Waldmann TA, Wilson WH. Phase I dose escalation study of the anti-CD2 monoclonal antibody, siplizumab, with DA-EPOCH-R in aggressive peripheral T-cell lymphomas. Leukemia & Lymphoma. 1-4. PMID 29032710 DOI: 10.1080/10428194.2017.1387908  0.345
2017 Dubois S, Conlon KC, Müller JR, Hsu-Albert J, Beltran N, Bryant BR, Waldmann TA. IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56bright NK Cells and Increases NK-Cell Cytokine Release Capabilities. Cancer Immunology Research. 5: 929-938. PMID 28842470 DOI: 10.1158/2326-6066.Cir-17-0279  0.407
2017 Perera LP, Zhang M, Nakagawa M, Petrus MN, Maeda M, Kadin ME, Waldmann TA, Perera PY. Chimeric Antigen Receptor Modified T cells That Target Chemokine Receptor CCR4 as a Therapeutic Modality for T-cell Malignancies. American Journal of Hematology. PMID 28543380 DOI: 10.1002/Ajh.24794  0.45
2017 Chen J, Zhang Y, Petrus MN, Xiao W, Nicolae A, Raffeld M, Pittaluga S, Bamford RN, Nakagawa M, Ouyang ST, Epstein AL, Kadin ME, Del Mistro A, Woessner R, Jaffe ES, ... Waldmann TA, et al. Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations. Proceedings of the National Academy of Sciences of the United States of America. PMID 28356514 DOI: 10.1073/Pnas.1700682114  0.382
2017 Waldmann TA. JAK/STAT pathway directed therapy of T-cell leukemia/lymphoma: Inspired by functional and structural genomics. Molecular and Cellular Endocrinology. 451: 66-70. PMID 28214593 DOI: 10.1016/J.Mce.2017.02.019  0.404
2017 Waldmann TA, Chen J. Disorders of the JAK/STAT Pathway in T Cell Lymphoma Pathogenesis: Implications for Immunotherapy. Annual Review of Immunology. PMID 28182501 DOI: 10.1146/Annurev-Immunol-110416-120628  0.403
2016 Sharma K, Janik J, O'Mahony D, Stewart D, Pittaluga S, Stetler-Stevenson M, Jaffe ES, Raffeld M, Fleisher T, Lee C, Steinberg SM, Waldmann TA, Morris JC. Phase II study of alemtuzumab (CAMPATH-1®) in patients with HTLV-1-associated adult T-cell leukemia/lymphoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27486175 DOI: 10.1158/1078-0432.Ccr-16-1022  0.372
2016 Mocsár G, Volkó J, Rönnlund D, Widengren J, Nagy P, Szöllősi J, Tóth K, Goldman CK, Damjanovich S, Waldmann TA, Bodnár A, Vámosi G. MHC I Expression Regulates Co-clustering and Mobility of Interleukin-2 and -15 Receptors in T Cells. Biophysical Journal. 111: 100-12. PMID 27410738 DOI: 10.1016/J.Bpj.2016.05.044  0.384
2016 Hodson DJ, Shaffer AL, Xiao W, Wright GW, Schmitz R, Phelan JD, Yang Y, Webster DE, Rui L, Kohlhammer H, Nakagawa M, Waldmann TA, Staudt LM. Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2. Proceedings of the National Academy of Sciences of the United States of America. PMID 26993806 DOI: 10.1073/Pnas.1600557113  0.372
2016 Yeh CH, Bai XT, Moles R, Ratner L, Waldmann TA, Watanabe T, Nicot C. Erratum to: 'Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia'. Molecular Cancer. 15: 20. PMID 26936184 DOI: 10.1186/S12943-016-0504-8  0.322
2016 Yeh CH, Bai XT, Moles R, Ratner L, Waldmann TA, Toshiki W, Nicot C. Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia. Molecular Cancer. 15: 15. PMID 26880370 DOI: 10.1186/S12943-016-0500-Z  0.31
2016 Ju W, Zhang M, Wilson KM, Petrus MN, Bamford RN, Zhang X, Guha R, Ferrer M, Thomas CJ, Waldmann TA. Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin's lymphoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 26811457 DOI: 10.1073/Pnas.1524668113  0.348
2016 Williams R, Cooley S, Bachanova V, Waldmann TA, Blazar BR, Weisdorf DJ, Miller JS, Verneris MR. Role of Recipient CD8+ T Cell Exhaustion in the Rejection of Adoptively Transferred Haploidentical NK Cells Blood. 128: 503-503. DOI: 10.1182/Blood.V128.22.503.503  0.406
2015 Pilipow K, Roberto A, Roederer M, Waldmann TA, Mavilio D, Lugli E. IL15 and T-cell Stemness in T-cell-Based Cancer Immunotherapy. Cancer Research. 75: 5187-93. PMID 26627006 DOI: 10.1158/0008-5472.Can-15-1498  0.452
2015 Yu H, Sui Y, Wang Y, Sato N, Frey B, Xia Z, Waldmann TA, Berzofsky J. Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes. Plos One. 10: e0143001. PMID 26600079 DOI: 10.1371/Journal.Pone.0143001  0.418
2015 Parra M, Liu X, Derrick SC, Yang A, Molina-Cruz A, Barillas-Mury C, Zheng H, Thao Pham P, Sedegah M, Belmonte A, Litilit DD, Waldmann TA, Kumar S, Morris SL, Perera LP. Co-expression of Interleukin-15 Enhances the Protective Immune Responses Induced by Immunization with a Murine Malaria MVA-Based Vaccine Encoding the Circumsporozoite Protein. Plos One. 10: e0141141. PMID 26505634 DOI: 10.1371/Journal.Pone.0141141  0.315
2015 Janik JE, Morris JC, O'Mahony D, Pittaluga S, Jaffe ES, Redon CE, Bonner WM, Brechbiel MW, Paik CH, Whatley M, Chen C, Lee JH, Fleisher TA, Brown M, White JD, ... ... Waldmann TA, et al. 90Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin's lymphoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 26438866 DOI: 10.1073/Pnas.1516107112  0.421
2015 Zhang M, Mathews Griner LA, Ju W, Duveau DY, Guha R, Petrus MN, Wen B, Maeda M, Shinn P, Ferrer M, Conlon KD, Bamford RN, O'Shea JJ, Thomas CJ, Waldmann TA. Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 112: 12480-5. PMID 26396258 DOI: 10.1073/Pnas.1516208112  0.434
2015 Jain S, Chen J, Nicolae A, Wang H, Shin DM, Adkins EB, Sproule TJ, Leeth CM, Sakai T, Kovalchuk AL, Raffeld M, Ward JM, Rehg JE, Waldmann TA, Jaffe ES, et al. IL-21-Driven Neoplasms in SJL Mice Mimic Some Key Features of Human Angioimmunoblastic T-Cell Lymphoma. The American Journal of Pathology. PMID 26363366 DOI: 10.1016/J.Ajpath.2015.07.021  0.464
2015 Kreitman RJ, Stetler-Stevenson M, Jaffe ES, Conlon KC, Steinberg SM, Wilson WH, Waldmann TA, Pastan I. Complete remissions of adult T-cell leukemia with anti-CD25 recombinant immunotoxin LMB-2 and chemotherapy to block immunogenicity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26350263 DOI: 10.1158/1078-0432.Ccr-15-1412  0.351
2015 Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, ... Waldmann TA, et al. Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. Immunity. 42: 826-38. PMID 25992859 DOI: 10.1016/J.Immuni.2015.04.018  0.388
2015 Waldmann TA. The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy. Cancer Immunology Research. 3: 219-27. PMID 25736261 DOI: 10.1158/2326-6066.Cir-15-0009  0.426
2015 Ji Y, Wrzesinski C, Yu Z, Hu J, Gautam S, Hawk NV, Telford WG, Palmer DC, Franco Z, Sukumar M, Roychoudhuri R, Clever D, Klebanoff CA, Surh CD, Waldmann TA, et al. miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines. Proceedings of the National Academy of Sciences of the United States of America. 112: 476-81. PMID 25548153 DOI: 10.1073/Pnas.1422916112  0.322
2015 Conlon KC, Lugli E, Welles HC, Rosenberg SA, Fojo AT, Morris JC, Fleisher TA, Dubois SP, Perera LP, Stewart DM, Goldman CK, Bryant BR, Decker JM, Chen J, Worthy TA, ... ... Waldmann TA, et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 74-82. PMID 25403209 DOI: 10.1200/Jco.2014.57.3329  0.427
2015 Yu P, Petrus MN, Ju W, Zhang M, Conlon KC, Nakagawa M, Maeda M, Bamford RN, Waldmann TA. Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model. Leukemia. 29: 556-66. PMID 25118879 DOI: 10.1038/Leu.2014.241  0.345
2015 Dubois S, Mueller J, Feigenbaum L, Waldmann TA. Leukemia/lymphoma development in IL-15-deficient TCR-transgenic mice Journal For Immunotherapy of Cancer. 3: 67. DOI: 10.1186/2051-1426-3-S2-P67  0.401
2015 Morishima C, McNeel DG, Patel MR, Kohrt HE, Waldmann TA, Thompson JA, Conlon KC, Sondel PM, Wakelee HA, Apodaca MC, Fling SP, Disis ML, Creekmore SP, Miller JS. CITN11-02 interim trial results: subcutaneous administration of recombinant human IL-15 (rhIL-15) is associated with expansion of peripheral blood CD56+ NK cells and CD8+ T cells Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P203  0.415
2015 Zhang M, Griner LAM, Ju W, Duveau DY, Guha R, Petrus MN, Wen B, Maeda M, Shinn P, Ferrer M, Conlon KD, Bamford RN, O'Shea JJ, Thomas CJ, Waldmann TA. Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia Proceedings of the National Academy of Sciences of the United States of America. 112: 12480-12485. DOI: 10.1186/1742-4690-12-S1-O42  0.421
2015 Miller JS, Verneris MR, Curtsinger J, DeFor TE, McKenna D, Waldmann TA, Blazar BR, Weisdorf DJ, Cooley S. A Phase I Study of Intravenous NCI IL-15 to Enhance Adoptively Transferred NK Cells Uncovers Defects in CD16 Triggered IFNγ Production and Competition Between Donor NK and Recipient T Cells Blood. 126: 566-566. DOI: 10.1182/Blood.V126.23.566.566  0.438
2015 Nakagawa M, Schmitz R, Xiao W, Goldman CK, Xu W, Yang Y, Yu X, Waldmann TA, Staudt LM. Abstract 3936: Frequent gain-of-function CCR4 mutations in adult T-cell leukemia/lymphoma (ATLL) Cancer Research. 75: 3936-3936. DOI: 10.1158/1538-7445.Am2015-3936  0.353
2015 Wen B, Zhang M, Dilillo D, Ravetch JV, Waldmann TA. Abstract 1332: Interleukin-15 enhances rituximab-dependent cytotoxicity ex vivo and in vivo against a mouse lymphoma expressing human CD20 Cancer Research. 75: 1332-1332. DOI: 10.1158/1538-7445.Am2015-1332  0.427
2015 Waldmann TA. ID: 238: IL-15 markedly augmented the number of circulating NK cells and enhanced ADCC mediated by tumor-directed monoclonal antibodies Cytokine. 76: 108-109. DOI: 10.1016/J.Cyto.2015.08.241  0.471
2014 Zhang Y, Tian S, Liu Z, Zhang J, Zhang M, Bosenberg MW, Kedl RM, Waldmann TA, Storkus WJ, Falo LD, You Z. Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency. Oncoimmunology. 3: e959321. PMID 25941586 DOI: 10.4161/21624011.2014.959321  0.396
2014 Nakagawa M, Schmitz R, Xiao W, Goldman CK, Xu W, Yang Y, Yu X, Waldmann TA, Staudt LM. Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma. The Journal of Experimental Medicine. 211: 2497-505. PMID 25488980 DOI: 10.1084/Jem.20140987  0.343
2014 Waldmann TA. Interleukin-15 in the treatment of cancer. Expert Review of Clinical Immunology. 10: 1689-701. PMID 25359408 DOI: 10.1586/1744666X.2014.973856  0.42
2014 Nizsalóczki E, Csomós I, Nagy P, Fazekas Z, Goldman CK, Waldmann TA, Damjanovich S, Vámosi G, Mátyus L, Bodnár A. Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 15: 3969-78. PMID 25297818 DOI: 10.1002/Cphc.201402501  0.393
2014 Berkowitz JL, Janik JE, Stewart DM, Jaffe ES, Stetler-Stevenson M, Shih JH, Fleisher TA, Turner M, Urquhart NE, Wharfe GH, Figg WD, Peer CJ, Goldman CK, Waldmann TA, Morris JC. Safety, efficacy, and pharmacokinetics/pharmacodynamics of daclizumab (anti-CD25) in patients with adult T-cell leukemia/lymphoma. Clinical Immunology (Orlando, Fla.). 155: 176-87. PMID 25267440 DOI: 10.1016/J.Clim.2014.09.012  0.43
2014 Yu P, Bamford RN, Waldmann TA. IL-15-dependent CD8+ CD122+ T cells ameliorate experimental autoimmune encephalomyelitis by modulating IL-17 production by CD4+ T cells. European Journal of Immunology. 44: 3330-41. PMID 25142300 DOI: 10.1002/Eji.201444675  0.405
2014 Müller JR, Waldmann TA, Dubois S. Loss of cytotoxicity and gain of cytokine production in murine tumor-activated NK cells. Plos One. 9: e102793. PMID 25101668 DOI: 10.1371/Journal.Pone.0102793  0.396
2014 Nicolae A, Xi L, Pittaluga S, Abdullaev Z, Pack SD, Chen J, Waldmann TA, Jaffe ES, Raffeld M. Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas. Leukemia. 28: 2244-8. PMID 24947020 DOI: 10.1038/Leu.2014.200  0.33
2014 Ju W, Zhang M, Petrus M, Maeda M, Pise-Masison CA, Waldmann TA. Combination of 9-aminoacridine with Campath-1H provides effective therapy for a murine model of adult T-cell leukemia. Retrovirology. 11: 43. PMID 24890041 DOI: 10.1186/1742-4690-11-43  0.421
2014 Nguyen VP, Chen J, Petrus MN, Goldman CK, Kruhlak MJ, Bamford RN, Waldmann TA. A new domain in the Toll/IL-1R domain-containing adaptor inducing interferon-β factor protein amino terminus is important for tumor necrosis factor-α receptor-associated factor 3 association, protein stabilization and interferon signaling. Journal of Innate Immunity. 6: 377-93. PMID 24577058 DOI: 10.1159/000356408  0.316
2014 Morris JC, Ramlogan-Steel CA, Yu P, Black BA, Mannan P, Allison JP, Waldmann TA, Steel JC. Vaccination with tumor cells expressing IL-15 and IL-15Rα inhibits murine breast and prostate cancer. Gene Therapy. 21: 393-401. PMID 24572789 DOI: 10.1038/Gt.2014.10  0.403
2014 Morishima C, McNeel DG, Patel MR, Kohrt H, Waldmann TA, Thompson JA, Conlon K, M Sondel P, Wakelee H, Disis ML, Creekmore SP, Miller JS. CITN11-02 interim trial results: subcutaneous administration of recombinant human IL-15 (rhil-15) is associated with robust expansion of peripheral blood CD56+ NK cells Journal For Immunotherapy of Cancer. 2. DOI: 10.1186/2051-1426-2-S3-P80  0.424
2014 Margolin K, Wong HC, Morishima C, Hernandez L, Ernstoff M, Rhode PR, Waldmann TA. CITN-06: a Phase I/expansion trial of alt-803, an IL-15 superagonist, in patients with advanced melanoma Journal For Immunotherapy of Cancer. 2: 79. DOI: 10.1186/2051-1426-2-S3-P79  0.408
2014 Dubois S, Müller J, Feigenbaum L, Waldmann TA. NK cells protect TCR-transgenic mice from developing fetal leukemia Journal For Immunotherapy of Cancer. 2: 167. DOI: 10.1186/2051-1426-2-S3-P167  0.403
2014 Massoud R, Enose-Akahata Y, Brunetto GS, Ohayon J, Fenton K, Cortese I, Waldmann TA, Jacobson S. Clinical trial of a humanized monoclonal anti-IL15Rβ (CD122), in HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP) Retrovirology. 11: 1-1. DOI: 10.1186/1742-4690-11-S1-O6  0.36
2014 Nakagawa M, Schmitz R, Xiao W, Goldman CK, Xu W, Yang Y, Waldmann TA, Staudt LM. A Gain-of-Function CCR4 Mutations in Adult T-Cell Leukemia/Lymphoma (ATLL) Enhance the Chemotactic Abilities and PI3K/AKT Activation Blood. 124: 3566-3566. DOI: 10.1182/Blood.V124.21.3566.3566  0.354
2014 Conlon KC, Lugli E, Rosenberg SA, Morris JC, Fleisher T, Welles H, Dubois S, Perera L, Goldman C, Bryant B, Decker J, Shih J, Worthy T, Figg W, Peer C, ... ... Waldmann TA, et al. Abstract 2575: Results from the first-in-human phase I trials of recombinant human Interleukin 15 (rhIL-15) administered as a daily 30 minute intravenous infusion (IVB) for 12 consecutive days or as continuous intravenous infusion (CIV) for 240 hours in patients with refractory metastatic cancers Cancer Research. 74: 2575-2575. DOI: 10.1158/1538-7445.Am2014-2575  0.372
2014 Nizsalóczki E, Csomós I, Nagy P, Fazekas Z, Goldman CK, Waldmann TA, Damjanovich S, Vámosi G, Mátyus L, Bodnár A. Inside Back Cover: Distinct Spatial Relationship of the Interleukin‐9 Receptor with Interleukin‐2 Receptor and Major Histocompatibility Complex Glycoproteins in Human T Lymphoma Cells (ChemPhysChem 18/2014) Chemphyschem. 15: 4135-4135. DOI: 10.1002/Cphc.201490093  0.335
2013 Waldmann TA. The biology of IL-15: implications for cancer therapy and the treatment of autoimmune disorders. The Journal of Investigative Dermatology. Symposium Proceedings. 16: S28-30. PMID 24326545 DOI: 10.1038/Jidsymp.2013.8  0.384
2013 Chen J, Feigenbaum L, Awasthi P, Butcher DO, Anver MR, Golubeva YG, Bamford R, Zhang X, St Claire MB, Thomas CJ, Discepolo V, Jabri B, Waldmann TA. Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Rα. Proceedings of the National Academy of Sciences of the United States of America. 110: 13534-9. PMID 23904478 DOI: 10.1073/Pnas.1312911110  0.375
2013 Bellon M, Ko NL, Lee MJ, Yao Y, Waldmann TA, Trepel JB, Nicot C. Adult T-cell leukemia cells overexpress Wnt5a and promote osteoclast differentiation. Blood. 121: 5045-54. PMID 23660959 DOI: 10.1182/Blood-2012-07-439109  0.367
2013 Chen J, Pise-Masison CA, Shih JH, Morris JC, Janik JE, Conlon KC, Keating A, Waldmann TA. Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia. Blood. 121: 2029-37. PMID 23321252 DOI: 10.1182/Blood-2012-05-427773  0.442
2013 Shah NN, Waldmann TA. GVL for ATL? Blood. 121: 6-7. PMID 23287623 DOI: 10.1182/Blood-2012-11-464628  0.312
2013 Lugli E, Dominguez MH, Gattinoni L, Chattopadhyay PK, Bolton DL, Song K, Klatt NR, Brenchley JM, Vaccari M, Gostick E, Price DA, Waldmann TA, Restifo NP, Franchini G, Roederer M. Superior T memory stem cell persistence supports long-lived T cell memory. The Journal of Clinical Investigation. 123: 594-9. PMID 23281401 DOI: 10.1172/Jci66327  0.342
2013 Yokoyama S, Perera PY, Waldmann TA, Hiroi T, Perera LP. Tofacitinib, a janus kinase inhibitor demonstrates efficacy in an IL-15 transgenic mouse model that recapitulates pathologic manifestations of celiac disease. Journal of Clinical Immunology. 33: 586-94. PMID 23269601 DOI: 10.1007/S10875-012-9849-Y  0.398
2013 Waldmann TA, Conlon KC, Stewart DM, Worthy TA, Janik JE, Fleisher TA, Albert PS, Figg WD, Spencer SD, Raffeld M, Decker JR, Goldman CK, Bryant BR, Petrus MN, Creekmore SP, et al. Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia. Blood. 121: 476-84. PMID 23212516 DOI: 10.1182/Blood-2012-08-450585  0.447
2012 Müller JR, Waldmann TA, Kruhlak MJ, Dubois S. Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells. The Journal of Biological Chemistry. 287: 40328-38. PMID 23074221 DOI: 10.1074/Jbc.M112.378612  0.373
2012 Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, ... ... Waldmann TA, et al. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 490: 116-20. PMID 22885699 DOI: 10.1038/Nature11378  0.347
2012 Simone CB, Morris JC, Stewart DM, Urquhart NE, Janik JE, Kreitman RJ, Lita E, Conlon K, Wharfe G, Waldmann TA, Kaushal A. Radiation therapy for the management of patients with HTLV-1-associated adult T-cell leukemia/lymphoma. Blood. 120: 1816-9. PMID 22730536 DOI: 10.1182/Blood-2012-01-401349  0.315
2012 Yang Y, Shaffer AL, Emre NC, Ceribelli M, Zhang M, Wright G, Xiao W, Powell J, Platig J, Kohlhammer H, Young RM, Zhao H, Yang Y, Xu W, Buggy JJ, ... ... Waldmann TA, et al. Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. Cancer Cell. 21: 723-37. PMID 22698399 DOI: 10.1016/J.Ccr.2012.05.024  0.34
2012 Zhang M, Ju W, Yao Z, Yu P, Wei BR, Simpson RM, Waitz R, Fassò M, Allison JP, Waldmann TA. Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice. Journal of Immunology (Baltimore, Md. : 1950). 188: 6156-64. PMID 22593619 DOI: 10.4049/Jimmunol.1102604  0.426
2012 Yu P, Steel JC, Zhang M, Morris JC, Waitz R, Fasso M, Allison JP, Waldmann TA. Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model. Proceedings of the National Academy of Sciences of the United States of America. 109: 6187-92. PMID 22474386 DOI: 10.1073/Pnas.1203479109  0.439
2012 Müller JR, Waldmann TA, Dubois S. Selective dependence of H2-M3-restricted CD8 responses on IL-15. Journal of Immunology (Baltimore, Md. : 1950). 188: 2575-82. PMID 22312130 DOI: 10.4049/Jimmunol.1102393  0.415
2012 Vyas VV, Esposito D, Sumpter TL, Broadt TL, Hartley J, Knapp Iv GC, Cheng W, Jiang MS, Roach JM, Yang X, Giardina SL, Mitra G, Yovandich JL, Creekmore SP, Waldmann TA, et al. Clinical manufacturing of recombinant human interleukin 15. I. Production cell line development and protein expression in E. coli with stop codon optimization Biotechnology Progress. 28: 497-507. PMID 22162520 DOI: 10.1002/Btpr.746  0.356
2012 Perera PY, Lichy JH, Waldmann TA, Perera LP. The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use. Microbes and Infection / Institut Pasteur. 14: 247-61. PMID 22064066 DOI: 10.1016/J.Micinf.2011.10.006  0.322
2012 Chen J, Petrus M, Bamford R, Shih JH, Morris JC, Janik JE, Waldmann TA. Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemia. Blood. 119: 137-43. PMID 22049515 DOI: 10.1182/Blood-2011-04-346759  0.421
2012 Steel JC, Waldmann TA, Morris JC. Interleukin-15 biology and its therapeutic implications in cancer. Trends in Pharmacological Sciences. 33: 35-41. PMID 22032984 DOI: 10.1016/J.Tips.2011.09.004  0.451
2012 Cooley S, Verneris MR, Curtsinger J, McKenna D, Weisdorf DJ, Blazar BR, Waldmann TA, Miller JS. Recombinant Human IL-15 Promotes in Vivo Expansion of Adoptively Transferred NK Cells in a First-in-Human Phase I Dose Escalation Study in Patients with AML Blood. 120: 894-894. DOI: 10.1182/Blood.V120.21.894.894  0.413
2011 Sneller MC, Kopp WC, Engelke KJ, Yovandich JL, Creekmore SP, Waldmann TA, Lane HC. IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood. Blood. 118: 6845-8. PMID 22067383 DOI: 10.1182/Blood-2011-09-377804  0.407
2011 Elliott NE, Cleveland SM, Grann V, Janik J, Waldmann TA, Davé UP. FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma Blood. 118: 3911-3921. PMID 21821710 DOI: 10.1182/Blood-2010-12-319467  0.355
2011 Wuest SC, Edwan JH, Martin JF, Han S, Perry JS, Cartagena CM, Matsuura E, Maric D, Waldmann TA, Bielekova B. A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy. Nature Medicine. 17: 604-9. PMID 21532597 DOI: 10.1038/Nm.2365  0.473
2011 Waldmann TA, Lugli E, Roederer M, Perera LP, Smedley JV, Macallister RP, Goldman CK, Bryant BR, Decker JM, Fleisher TA, Lane HC, Sneller MC, Kurlander RJ, Kleiner DE, Pletcher JM, et al. Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques. Blood. 117: 4787-95. PMID 21385847 DOI: 10.1182/Blood-2010-10-311456  0.424
2011 DePaolo RW, Abadie V, Tang F, Fehlner-Peach H, Hall JA, Wang W, Marietta EV, Kasarda DD, Waldmann TA, Murray JA, Semrad C, Kupfer SS, Belkaid Y, Guandalini S, Jabri B. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. 471: 220-4. PMID 21307853 DOI: 10.1038/Nature09849  0.386
2011 Sato N, Sabzevari H, Fu S, Ju W, Petrus MN, Bamford RN, Waldmann TA, Tagaya Y. Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα. Blood. 117: 4032-40. PMID 21304101 DOI: 10.1182/Blood-2010-09-307504  0.441
2011 Ju W, Zhang M, Jiang JK, Thomas CJ, Oh U, Bryant BR, Chen J, Sato N, Tagaya Y, Morris JC, Janik JE, Jacobson S, Waldmann TA. CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP. Blood. 117: 1938-46. PMID 21106989 DOI: 10.1182/Blood-2010-09-305425  0.45
2011 Waldmann TA, Janik J, Morris JC, Conlon K, O'Mahony D, Pittaluga S, Jaffe ES, Brechbiel M, Paik CH, Chen C, Whatley M, Fleisher TA, White J, Stewart D, Fioravanti S, et al. Yttrium-90 Radiolabeled Daclizumab, An Anti-CD25 Monoclonal Antibody, Provides Effective Therapy for Refractory and Relapsed Hodgkin's Lymphoma, Blood. 118: 3706-3706. DOI: 10.1182/Blood.V118.21.3706.3706  0.423
2011 Kreitman RJ, Singh R, Stetler-Stevenson M, Waldmann TA, Pastan I. Regression of Adult T-Cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 Preceded by Chemotherapy Blood. 118: 2575-2575. DOI: 10.1182/Blood.V118.21.2575.2575  0.401
2010 Yu P, Steel JC, Zhang M, Morris JC, Waldmann TA. Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 6019-28. PMID 20924130 DOI: 10.1158/1078-0432.Ccr-10-1966  0.388
2010 Chen J, Petrus M, Bryant BR, Nguyen VP, Goldman CK, Bamford R, Morris JC, Janik JE, Waldmann TA. Autocrine/paracrine cytokine stimulation of leukemic cell proliferation in smoldering and chronic adult T-cell leukemia. Blood. 116: 5948-56. PMID 20858854 DOI: 10.1182/Blood-2010-04-277418  0.438
2010 Pancewicz J, Taylor JM, Datta A, Baydoun HH, Waldmann TA, Hermine O, Nicot C. Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 107: 16619-24. PMID 20823234 DOI: 10.1073/Pnas.1010722107  0.366
2010 Zielinski RJ, Smedley JV, Perera PY, Silvera PM, Waldmann TA, Capala J, Perera LP. Smallpox vaccine with integrated IL-15 demonstrates enhanced in vivo viral clearance in immunodeficient mice and confers long term protection against a lethal monkeypox challenge in cynomolgus monkeys. Vaccine. 28: 7081-91. PMID 20728526 DOI: 10.1016/J.Vaccine.2010.08.008  0.307
2010 Lugli E, Goldman CK, Perera LP, Smedley J, Pung R, Yovandich JL, Creekmore SP, Waldmann TA, Roederer M. Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates. Blood. 116: 3238-48. PMID 20631381 DOI: 10.1182/Blood-2010-03-275438  0.403
2010 Kolibab K, Yang A, Derrick SC, Waldmann TA, Perera LP, Morris SL. Highly persistent and effective prime/boost regimens against tuberculosis that use a multivalent modified vaccine virus Ankara-based tuberculosis vaccine with interleukin-15 as a molecular adjuvant. Clinical and Vaccine Immunology : Cvi. 17: 793-801. PMID 20357059 DOI: 10.1128/Cvi.00006-10  0.361
2010 Steel JC, Ramlogan CA, Yu P, Sakai Y, Forni G, Waldmann TA, Morris JC. Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help. Cancer Research. 70: 1072-81. PMID 20086176 DOI: 10.1158/0008-5472.Can-09-1301  0.423
2010 Berkowitz JL, Janik JE, Stewart DM, Fioravanti S, Jaffe ES, Fleisher TA, Urquhart N, Wharfe GH, Waldmann TA, Morris JC. Phase II trial of daclizumab in human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATL). Journal of Clinical Oncology. 28: 8043-8043. DOI: 10.1200/Jco.2010.28.15_Suppl.8043  0.379
2010 Ju W, Zhang M, Bryant BR, Chen J, Morris JC, Janik JE, Waldmann TA, Jiang J, Thomas CJ, Jacobson S, Oh U. Abstract 2526: CP690550 inhibits interleukin-2 (IL-2), IL-9 and IL-15 mediated JAK3 activation and proliferation of T cells obtained from patients with HTLV-1-associated adult T cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) Cancer Research. 70: 2526-2526. DOI: 10.1158/1538-7445.Am10-2526  0.434
2010 Waldmann TA. PL3-1 IL-15 for the treatment of metastatic malignant melanoma and metastatic renal cell cancer Cytokine. 52: 68-68. DOI: 10.1016/J.Cyto.2010.07.287  0.341
2009 Yokoyama S, Watanabe N, Sato N, Perera PY, Filkoski L, Tanaka T, Miyasaka M, Waldmann TA, Hiroi T, Perera LP. Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes. Proceedings of the National Academy of Sciences of the United States of America. 106: 15849-54. PMID 19805228 DOI: 10.1073/Pnas.0908834106  0.39
2009 Morris JC, Waldmann TA. Antibody-based therapy of leukaemia. Expert Reviews in Molecular Medicine. 11: e29. PMID 19788782 DOI: 10.1017/S1462399409001215  0.381
2009 Soman G, Yang X, Jiang H, Giardina S, Vyas V, Mitra G, Yovandich J, Creekmore SP, Waldmann TA, Quiñones O, Alvord WG. MTS dye based colorimetric CTLL-2 cell proliferation assay for product release and stability monitoring of interleukin-15: assay qualification, standardization and statistical analysis. Journal of Immunological Methods. 348: 83-94. PMID 19646987 DOI: 10.1016/J.Jim.2009.07.010  0.361
2009 Zhang M, Yao Z, Garmestani K, Yu S, Goldman CK, Paik CH, Brechbiel MW, Carrasquillo JA, Waldmann TA. Preclinical evaluation of an anti-CD25 monoclonal antibody, 7G7/B6, armed with the beta-emitter, yttrium-90, as a radioimmunotherapeutic agent for treating lymphoma. Cancer Biotherapy & Radiopharmaceuticals. 24: 303-9. PMID 19538052 DOI: 10.1089/Cbr.2008.0577  0.305
2009 Kraynyak KA, Kutzler MA, Cisper NJ, Laddy DJ, Morrow MP, Waldmann TA, Weiner DB. Plasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo. Human Gene Therapy. 20: 1143-56. PMID 19530914 DOI: 10.1089/Hum.2009.025  0.399
2009 Zhang M, Yao Z, Dubois S, Ju W, Müller JR, Waldmann TA. Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 106: 7513-8. PMID 19383782 DOI: 10.1073/Pnas.0902637106  0.408
2009 O'Mahony D, Morris JC, Stetler-Stevenson M, Matthews H, Brown MR, Fleisher T, Pittaluga S, Raffeld M, Albert PS, Reitsma D, Kaucic K, Hammershaimb L, Waldmann TA, Janik JE. EBV-related lymphoproliferative disease complicating therapy with the anti-CD2 monoclonal antibody, siplizumab, in patients with T-cell malignancies. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 2514-22. PMID 19293260 DOI: 10.1158/1078-0432.Ccr-08-1254  0.421
2009 Pise-Masison CA, Radonovich M, Dohoney K, Morris JC, O'Mahony D, Lee MJ, Trepel J, Waldmann TA, Janik JE, Brady JN. Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability. Blood. 113: 4016-26. PMID 19131553 DOI: 10.1182/Blood-2008-08-175901  0.374
2009 Chen J, Zhang M, Ju W, Waldmann TA. Effective treatment of a murine model of adult T-cell leukemia using depsipeptide and its combination with unmodified daclizumab directed toward CD25. Blood. 113: 1287-93. PMID 18948574 DOI: 10.1182/Blood-2008-04-149658  0.393
2008 Miyagawa F, Tagaya Y, Kim BS, Patel HJ, Ishida K, Ohteki T, Waldmann TA, Katz SI. IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease. Journal of Immunology (Baltimore, Md. : 1950). 181: 1109-19. PMID 18606663 DOI: 10.4049/Jimmunol.181.2.1109  0.39
2008 Yeh S, Wroblewski K, Buggage R, Li Z, Kurup SK, Sen HN, Dahr S, Sran P, Reed GF, Robinson R, Ragheb JA, Waldmann TA, Nussenblatt RB. High-dose humanized anti-IL-2 receptor alpha antibody (daclizumab) for the treatment of active, non-infectious uveitis. Journal of Autoimmunity. 31: 91-7. PMID 18571896 DOI: 10.1016/J.Jaut.2008.05.001  0.366
2008 Morris JC, Waldmann TA, Janik JE. Receptor-directed therapy of T-cell leukemias and lymphomas. Journal of Immunotoxicology. 5: 235-48. PMID 18569395 DOI: 10.1080/15476910802129661  0.411
2008 Terabe M, Tagaya Y, Zhu Q, Granger L, Roederer M, Waldmann TA, Berzofsky JA. IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cells. Journal of Immunology (Baltimore, Md. : 1950). 180: 7276-86. PMID 18490727 DOI: 10.4049/Jimmunol.180.11.7276  0.432
2008 Oh S, Perera LP, Terabe M, Ni L, Waldmann TA, Berzofsky JA. IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 105: 5201-6. PMID 18362335 DOI: 10.1073/Pnas.0801003105  0.418
2008 Chen J, Petrus M, Bryant BR, Phuc Nguyen V, Stamer M, Goldman CK, Bamford R, Morris JC, Janik JE, Waldmann TA. Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism. Blood. 111: 5163-72. PMID 18339896 DOI: 10.1182/Blood-2007-09-113654  0.467
2008 de Bakker BI, Bodnár A, van Dijk EM, Vámosi G, Damjanovich S, Waldmann TA, van Hulst NF, Jenei A, Garcia-Parajo MF. Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells. Journal of Cell Science. 121: 627-33. PMID 18287585 DOI: 10.1242/Jcs.019513  0.405
2008 Bodnár A, Nizsalóczki E, Mocsár G, Szalóki N, Waldmann TA, Damjanovich S, Vámosi G. A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions. Immunology Letters. 116: 117-25. PMID 18280585 DOI: 10.1016/J.Imlet.2007.12.014  0.38
2008 Dubois S, Patel HJ, Zhang M, Waldmann TA, Müller JR. Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action. Journal of Immunology (Baltimore, Md. : 1950). 180: 2099-106. PMID 18250415 DOI: 10.4049/Jimmunol.180.4.2099  0.424
2008 O’Mahony D, Janik JE, Carrasquillo JA, Seam P, Fiorillo JA, Stewart D, Paik CH, Fioravanti S, Whatley M, Pittaluga S, Brechbiel MW, Morris JC, Waldmann TA. Yttrium-90 Radiolabeled Humanized Monoclonal Antibody to CD25 in Refractory and Relapsed Hodgkin’s Lymphoma Blood. 112: 231-231. DOI: 10.1182/Blood.V112.11.231.231  0.385
2008 Sharma K, Janik JE, O’Mahony D, Stewart D, Pittaluga S, Stetler-Stevenson M, Jaffe ES, Raffeld M, Fleisher TA, Lee CC, Urquhart N, Steinberg S, Waldmann TA, Morris JC. Alemtuzumab (Campath 1-H) in Patients with HTLV-1 Associated Adult T-Cell Leukemia/Lymphoma. Blood. 112: 2010-2010. DOI: 10.1182/Blood.V112.11.2010.2010  0.325
2007 Boyer JD, Robinson TM, Kutzler MA, Vansant G, Hokey DA, Kumar S, Parkinson R, Wu L, Sidhu MK, Pavlakis GN, Felber BK, Brown C, Silvera P, Lewis MG, Monforte J, ... Waldmann TA, et al. Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid. Proceedings of the National Academy of Sciences of the United States of America. 104: 18648-53. PMID 18000037 DOI: 10.1073/Pnas.0709198104  0.325
2007 Bene L, Kanyári Z, Bodnár A, Kappelmayer J, Waldmann TA, Vámosi G, Damjanovich L. Colorectal carcinoma rearranges cell surface protein topology and density in CD4+ T cells Biochemical and Biophysical Research Communications. 361: 202-207. PMID 17658476 DOI: 10.1016/J.Bbrc.2007.07.013  0.399
2007 Waldmann TA. Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma. Oncogene. 26: 3699-3703. PMID 17530023 DOI: 10.1038/Sj.Onc.1210368  0.45
2007 Zhang M, Yao Z, Patel H, Garmestani K, Zhang Z, Talanov VS, Plascjak PS, Goldman CK, Janik JE, Brechbiel MW, Waldmann TA. Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1. Proceedings of the National Academy of Sciences of the United States of America. 104: 8444-8. PMID 17488826 DOI: 10.1073/Pnas.0702496104  0.319
2007 O'Mahony D, Morris JC, Quinn C, Gao W, Wilson WH, Gause B, Pittaluga S, Neelapu S, Brown M, Fleisher TA, Gulley JL, Schlom J, Nussenblatt R, Albert P, Davis TA, ... ... Waldmann TA, et al. A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy Clinical Cancer Research. 13: 958-964. PMID 17289891 DOI: 10.1158/1078-0432.Ccr-06-1974  0.354
2007 Waldmann TA. Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey. Journal of Clinical Immunology. 27: 1-18. PMID 17216565 DOI: 10.1007/S10875-006-9060-0  0.447
2007 Sato N, Patel HJ, Waldmann TA, Tagaya Y. The IL-15/IL-15Rα on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells Proceedings of the National Academy of Sciences of the United States of America. 104: 588-593. PMID 17202253 DOI: 10.1073/Pnas.0610115104  0.413
2007 O’Mahony D, Morris JC, Stetler-Stevenson M, Matthews H, Pittaluga S, Albert P, Kaucic K, Hammershaimb L, Waldmann TA, Janik JE. EBV-Related Lymphoproliferative Disease Complicating Therapy with Siplizumab, a Novel Anti-CD2 Mediated T- and NK-Cell Depleting Agent, in Patients with T-Cell Malignancies. Blood. 110: 3565-3565. DOI: 10.1182/Blood.V110.11.3565.3565  0.388
2007 Sato N, Waldmann TA, Tagaya Y. 134 Accessory Cells Enable Cytokine Response of Naïve T Cells Through Cellular Contact Without Antigen Cytokine. 39: 37-37. DOI: 10.1016/J.Cyto.2007.07.139  0.402
2007 Chen J, Petrus M, Bryant B, Nguyen VP, Stamer M, Goldman C, Bamford R, Morris JC, Janik JE, Waldmann TA. 18 Induction of the IL-9 Gene by HTLV-I Tax Stimulates the Spontaneous Proliferation of Primary ATL Cells by a Paracrine Mechanism Cytokine. 39: 5-6. DOI: 10.1016/J.Cyto.2007.07.023  0.39
2006 Zhang M, Yao Z, Zhang Z, Garmestani K, Talanov VS, Plascjak PS, Yu S, Kim HS, Goldman CK, Paik CH, Brechbiel MW, Carrasquillo JA, Waldmann TA. The anti-CD25 monoclonal antibody 7G7/B6, armed with the alpha-emitter 211At, provides effective radioimmunotherapy for a murine model of leukemia. Cancer Research. 66: 8227-32. PMID 16912202 DOI: 10.1158/0008-5472.Can-06-1189  0.328
2006 Dubois S, Waldmann TA, Müller JR. ITK and IL-15 support two distinct subsets of CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 12075-80. PMID 16880398 DOI: 10.1073/Pnas.0605212103  0.408
2006 Waldmann TA. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design Nature Reviews Immunology. 6: 595-601. PMID 16868550 DOI: 10.1038/Nri1901  0.361
2006 Waldmann TA, Morris JC. Development of Antibodies and Chimeric Molecules for Cancer Immunotherapy Advances in Immunology. 90: 83-131. PMID 16730262 DOI: 10.1016/S0065-2776(06)90003-0  0.326
2006 Bielekova B, Catalfamo M, Reichert-Scrivner S, Packer A, Cerna M, Waldmann TA, McFarland H, Henkart PA, Martin R. Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 103: 5941-6. PMID 16585503 DOI: 10.1073/Pnas.0601335103  0.416
2006 Zhang Z, Zhang M, Garmestani K, Talanov VS, Plascjak PS, Beck B, Goldman C, Brechbiel MW, Waldmann TA. Effective treatment of a murine model of adult T-cell leukemia using 211At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25. Blood. 108: 1007-12. PMID 16569769 DOI: 10.1182/Blood-2005-11-4757  0.379
2006 Datta A, Bellon M, Sinha-Datta U, Bazarbachi A, Lepelletier Y, Canioni D, Waldmann TA, Hermine O, Nicot C. Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence. Blood. 108: 1021-1029. PMID 16569765 DOI: 10.1182/Blood-2006-01-0067  0.367
2006 Zhang M, Yao Z, Zhang Z, Garmestani K, Goldman CK, Ravetch JV, Janik J, Brechbiel MW, Waldmann TA. Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors. Blood. 108: 705-10. PMID 16551968 DOI: 10.1182/Blood-2005-11-4607  0.383
2006 Wani MA, Haynes LD, Kim J, Bronson CL, Chaudhury C, Mohanty S, Waldmann TA, Robinson JM, Anderson CL. Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Proceedings of the National Academy of Sciences of the United States of America. 103: 5084-9. PMID 16549777 DOI: 10.1073/Pnas.0600548103  0.317
2006 Waldmann TA. Effective Cancer Therapy Through Immunomodulation Annual Review of Medicine. 57: 65-81. PMID 16409137 DOI: 10.1146/Annurev.Med.56.082103.104549  0.417
2006 Morris JC, Janik JE, White JD, Fleisher TA, Brown M, Tsudo M, Goldman CK, Bryant B, Petrus M, Top L, Lee CC, Gao W, Waldmann TA. Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia. Proceedings of the National Academy of Sciences of the United States of America. 103: 401-6. PMID 16387851 DOI: 10.1073/Pnas.0509575103  0.476
2006 Koon HB, Severy P, Hagg DS, Butler K, Hill T, Jones AG, Waldmann TA, Junghans RP. Antileukemic effect of daclizumab in CD25 high-expressing leukemias and impact of tumor burden on antibody dosing. Leukemia Research. 30: 190-203. PMID 16165209 DOI: 10.1016/J.Leukres.2005.06.007  0.338
2006 Sharma K, Janik J, O’Mahony D, O’Hagan D, Gao WW, Wharfe GH, Cranston BE, Waldmann TA, Morris JC. A phase II study of the efficacy and toxicity of alemtuzumab for the therapy of human T cell lymphotrophic virus-1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATL) Journal of Clinical Oncology. 24: 2535-2535. DOI: 10.1200/Jco.2006.24.18_Suppl.2535  0.384
2006 Oh S, Perera LP, Waldmann TA, Berzofsky JA. Overcoming CD4 deficiency to induce long-lived memory CD8+ CTL. Retrovirology. 3: 1-1. DOI: 10.1186/1742-4690-3-S1-S17  0.396
2006 Morrison BJ, Tagaya Y, Steel JC, Mannan P, Waldmann TA, Morris JC, Sakai Y. 429. Adenoviral-Mediated Interleukin-15 Receptor-α Gene Therapy of Murine Breast Cancer Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.494  0.426
2005 Janik JE, Morris JC, Stetler-Stevenson M, Gao WW, O'Hagan D, Moses LS, Taylor M, McEwen C, Hammershaimb LD, Waldmann TA. Phase I trial of siplizumab in CD2-positive lymphoproliferative disease. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 2533. PMID 27945817 DOI: 10.1200/Jco.2005.23.16_Suppl.2533  0.371
2005 Klebanoff CA, Gattinoni L, Torabi-Parizi P, Kerstann K, Cardones AR, Finkelstein SE, Palmer DC, Antony PA, Hwang ST, Rosenberg SA, Waldmann TA, Restifo NP. Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 9571-6. PMID 15980149 DOI: 10.1073/Pnas.0503726102  0.403
2005 Kutzler MA, Robinson TM, Chattergoon MA, Choo DK, Choo AY, Choe PY, Ramanathan MP, Parkinson R, Kudchodkar S, Tamura Y, Sidhu M, Roopchand V, Kim JJ, Pavlakis GN, Felber BK, ... Waldmann TA, et al. Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help. Journal of Immunology (Baltimore, Md. : 1950). 175: 112-23. PMID 15972637 DOI: 10.4049/Jimmunol.175.1.112  0.406
2005 Bene L, Szöllősi J, Szentesi G, Damjanovich L, Gáspár R, Waldmann TA, Damjanovich S. Detection of receptor trimers on the cell surface by flow cytometric fluorescence energy homotransfer measurements. Biochimica Et Biophysica Acta. 1744: 176-198. PMID 15950751 DOI: 10.1016/J.Bbamcr.2005.02.002  0.32
2005 Dubois SP, Waldmann TA, Müller JR. Survival adjustment of mature dendritic cells by IL-15. Proceedings of the National Academy of Sciences of the United States of America. 102: 8662-7. PMID 15932944 DOI: 10.1073/Pnas.0503360102  0.416
2005 Zhang M, Zhang Z, Goldman CK, Janik J, Waldmann TA. Combination therapy for adult T-cell leukemia-xenografted mice: flavopiridol and anti-CD25 monoclonal antibody. Blood. 105: 1231-6. PMID 15383455 DOI: 10.1182/Blood-2004-05-1709  0.401
2005 Kobayashi H, Dubois S, Sato N, Sabzevari H, Sakai Y, Waldmann TA, Tagaya Y. Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. Blood. 105: 721-727. PMID 15367431 DOI: 10.1182/Blood-2003-12-4187  0.437
2004 Oh SK, Perera LP, Burke DS, Waldmann TA, Berzofsky JA. IL-15/IL-15Rα-mediated avidity maturation of memory CD8 + T cells Proceedings of the National Academy of Sciences of the United States of America. 101: 15154-15159. PMID 15477598 DOI: 10.1073/Pnas.0406649101  0.433
2004 Zhang M, Zhang Z, Garmestani K, Goldman CK, Ravetch JV, Brechbiel MW, Carrasquillo JA, Waldmann TA. Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult t-cell leukemia. Cancer Research. 64: 5825-9. PMID 15313926 DOI: 10.1158/0008-5472.Can-04-1088  0.383
2004 Vámosi G, Bodnár A, Vereb G, Jenei A, Goldman CK, Langowski J, Tóth K, Mátyus L, Szöllosi J, Waldmann TA, Damjanovich S. IL-2 and IL-15 receptor α-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells Proceedings of the National Academy of Sciences of the United States of America. 101: 11082-11087. PMID 15263076 DOI: 10.1073/Pnas.0403916101  0.366
2004 Waldmann TA. Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases Arthritis Research & Therapy. 6: 174-177. PMID 15225362 DOI: 10.1186/Ar1202  0.388
2004 Janik JE, Morris JC, Pittaluga S, McDonald K, Raffeld M, Jaffe ES, Grant N, Gutierrez M, Waldmann TA, Wilson WH. Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma Blood. 104: 3355-3357. PMID 15205267 DOI: 10.1182/Blood-2003-11-3922  0.328
2004 Bielekova B, Richert N, Howard T, Blevins G, Markovic-Plese S, McCartin J, Frank JA, Würfel J, Ohayon J, Waldmann TA, McFarland HF, Martin R. Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta. Proceedings of the National Academy of Sciences of the United States of America. 101: 8705-8. PMID 15161974 DOI: 10.1073/Pnas.0402653101  0.304
2004 Wesley JN, McGee EC, Garmestani K, Brechbiel MW, Yordanov AT, Wu C, Gansow OA, Eckelman WC, Bacher JD, Flynn M, Goldman CK, MacLin M, Schwartz UP, Jackson-White T, Phillip CM, ... ... Waldmann TA, et al. Systemic radioimmunotherapy using a monoclonal antibody, anti-Tac directed toward the alpha subunit of the IL-2 receptor armed with the alpha-emitting radionuclides (212)Bi or (211)At. Nuclear Medicine and Biology. 31: 357-64. PMID 15028248 DOI: 10.1016/J.Nucmedbio.2003.08.011  0.41
2004 Klebanoff CA, Finkelstein SE, Surman DR, Lichtman MK, Gattinoni L, Theoret MR, Grewal N, Spiess PJ, Antony PA, Palmer DC, Tagaya Y, Rosenberg SA, Waldmann TA, Restifo NP. IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 1969-74. PMID 14762166 DOI: 10.1073/Pnas.0307298101  0.45
2004 Nussenblatt RB, Thompson DJS, Li Z, Chan CC, Peterson JS, Robinson RR, Shames RS, Nagarajan S, Tang MT, Mailman M, Velez G, Roy C, Levy-Clarke GA, Sujler EB, Djalilian A, ... ... Waldmann TA, et al. Corrigendum to “Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration” [J. Autoimmun. 21 (2004) 283–293] Journal of Autoimmunity. 23: 93. DOI: 10.1016/J.Jaut.2004.04.001  0.339
2003 Foss FM, Waldmann TA. Interleukin-2 receptor-directed therapies for cutaneous lymphomas. Hematology/Oncology Clinics of North America. 17: 1449-58. PMID 14710895 DOI: 10.1016/S0889-8588(03)00110-2  0.435
2003 Waldmann TA. IL-15 in the life and death of lymphocytes: immunotherapeutic implications. Trends in Molecular Medicine. 9: 517-521. PMID 14659465 DOI: 10.1016/J.Molmed.2003.10.005  0.397
2003 Dubois S, Shou W, Haneline LS, Fleischer S, Waldmann TA, Müller JR. Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 14169-74. PMID 14605212 DOI: 10.1073/Pnas.2335979100  0.412
2003 Nussenblatt RB, Thompson DJ, Li Z, Chan CC, Peterson JS, Robinson RR, Shames RS, Nagarajan S, Tang MT, Mailman M, Velez G, Roy C, Levy-Clarke GA, Suhler EB, Djalilian A, ... ... Waldmann TA, et al. Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration. Journal of Autoimmunity. 21: 283-93. PMID 14599854 DOI: 10.1016/S0896-8411(03)00113-6  0.32
2003 Waldmann TA. A novel means of favorably tipping the balance between cytopathic and regulatory T cells. Immunity. 19: 465-466. PMID 14563310 DOI: 10.1016/S1074-7613(03)00273-5  0.425
2003 Zhang Z, Zhang M, Ravetch JV, Goldman C, Waldmann TA. Effective therapy for a murine model of adult T-cell leukemia with the humanized anti-CD2 monoclonal antibody, MEDI-507 Blood. 102: 284-288. PMID 12649132 DOI: 10.1182/Blood-2002-11-3601  0.421
2003 Oh S, Berzofsky JA, Burke DS, Waldmann TA, Perera LP. Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity Proceedings of the National Academy of Sciences of the United States of America. 100: 3392-3397. PMID 12626740 DOI: 10.1073/Pnas.0630592100  0.404
2003 Zhang M, Zhang Z, Garmestani K, Schultz J, Axworthy DB, Goldman CK, Brechbiel MW, Carrasquillo JA, Waldmann TA. Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts Proceedings of the National Academy of Sciences of the United States of America. 100: 1891-1895. PMID 12569172 DOI: 10.1073/Pnas.0437788100  0.344
2003 Waldmann TA. The Meandering 45-Year Odyssey of a Clinical Immunologist* Annual Review of Immunology. 21: 1-27. PMID 12359737 DOI: 10.1146/Annurev.Immunol.21.120601.140933  0.409
2002 Dubois S, Mariner J, Waldmann TA, Tagaya Y. IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells Immunity. 17: 537-547. PMID 12433361 DOI: 10.1016/S1074-7613(02)00429-6  0.393
2002 Waldmann T. The contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for the immunotherapy of rheumatological diseases. Arthritis Research. S161-7. PMID 12110135 DOI: 10.1186/ar584  0.312
2002 Zhang M, Yao Z, Garmestani K, Axworthy DB, Zhang Z, Mallett RW, Theodore LJ, Goldman CK, Brechbiel MW, Carrasquillo JA, Waldmann TA. Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha-emitting radionuclide, bismuth 213. Blood. 100: 208-16. PMID 12070029 DOI: 10.1182/Blood-2002-01-0107  0.422
2002 Mariner JM, Mamane Y, Hiscott J, Waldmann TA, Azimi N. IFN regulatory factor 4 participates in the human T cell lymphotropic virus type I-mediated activation of the IL-15 receptor alpha promoter. Journal of Immunology (Baltimore, Md. : 1950). 168: 5667-74. PMID 12023365 DOI: 10.4049/Jimmunol.168.11.5667  0.406
2002 Waldmann TA. The IL-2/IL-15 receptor systems: Targets for immunotherapy Journal of Clinical Immunology. 22: 51-56. PMID 11998892 DOI: 10.1023/A:1014416616687  0.437
2002 Eicher DM, Damjanovich S, Waldmann TA. Oligomerization of IL-2Rα Cytokine. 17: 82-90. PMID 11886175 DOI: 10.1006/Cyto.2001.0978  0.363
2002 Matkó J, Bodnár A, Vereb G, Bene L, Vámosi G, Szentesi G, Szöllösi J, Gáspár R, Horejsi V, Waldmann TA, Damjanovich S. GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines. Febs Journal. 269: 1199-1208. PMID 11856346 DOI: 10.1046/J.0014-2956.2002.02759.X  0.411
2001 Azimi N, Nagai M, Jacobson S, Waldmann TA. IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients. Proceedings of the National Academy of Sciences of the United States of America. 98: 14559-64. PMID 11717409 DOI: 10.1073/Pnas.251540598  0.443
2001 Alileche A, Goldman CK, Waldmann TA. Differential Effects of IL-2 and IL-15 on Expression of IL-2 Receptor α Biochemical and Biophysical Research Communications. 285: 1302-1308. PMID 11478799 DOI: 10.1006/Bbrc.2001.5332  0.37
2001 Baldassarre G, Fedele M, Battista S, Vecchione A, Klein-Szanto AJ, Santoro M, Waldmann TA, Azimi N, Croce CM, Fusco A. Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. Proceedings of the National Academy of Sciences of the United States of America. 98: 7970-5. PMID 11427729 DOI: 10.1073/Pnas.141224998  0.414
2001 White JD, Wharfe G, Stewart DM, Maher VE, Eicher D, Herring B, Derby M, Jackson-Booth PG, Marshall M, Lucy D, Jain A, Cranston B, Hanchard B, Lee CC, Top LE, ... ... Waldmann TA, et al. The combination of zidovudine and interferon alpha-2B in the treatment of adult T-cell leukemia/lymphoma. Leukemia & Lymphoma. 40: 287-94. PMID 11426550 DOI: 10.3109/10428190109057927  0.357
2001 Perera LP, Goldman CK, Waldmann TA. Comparative assessment of virulence of recombinant vaccinia viruses expressing IL-2 and IL-15 in immunodeficient mice Proceedings of the National Academy of Sciences of the United States of America. 98: 5146-5151. PMID 11296252 DOI: 10.1073/Pnas.081080298  0.389
2001 Mariner JM, Lantz V, Waldmann TA, Azimi N. Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site. Journal of Immunology (Baltimore, Md. : 1950). 166: 2602-9. PMID 11160322 DOI: 10.4049/Jimmunol.166.4.2602  0.417
2001 Waldmann TA, Dubois S, Tagaya Y. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity. 14: 105-110. DOI: 10.1016/S1074-7613(01)00093-0  0.431
2000 Brechbiel MW, Waldmann TA. Anti-HER2 radioimmunotherapy. Breast Disease. 11: 125-132. PMID 15687598 DOI: 10.3233/Bd-1999-11111  0.301
2000 Waldmann TA, Levy R, Coller BS. Emerging Therapies: Spectrum of Applications of Monoclonal Antibody Therapy Hematology. 2000: 394-408. PMID 11701553 DOI: 10.1182/Asheducation-2000.1.394  0.408
2000 Azimi N, Mariner J, Jacobson S, Waldmann TA. How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis? Aids Research and Human Retroviruses. 16: 1717-22. PMID 11080816 DOI: 10.1089/08892220050193209  0.434
2000 Morris JC, Waldmann TA. Advances in interleukin 2 receptor targeted treatment Annals of the Rheumatic Diseases. 59. PMID 11053100 DOI: 10.1136/Ard.59.Suppl_1.I109  0.467
2000 Marks-Konczalik J, Dubois S, Losi JM, Sabzevari H, Yamada N, Feigenbaum L, Waldmann TA, Tagaya Y. IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 11445-11450. PMID 11016962 DOI: 10.1073/Pnas.200363097  0.431
2000 Azimi N, Shiramizu KM, Tagaya Y, Mariner J, Waldmann TA. Viral activation of interleukin-15 (IL-15): characterization of a virus-inducible element in the IL-15 promoter region. Journal of Virology. 74: 7338-48. PMID 10906187 DOI: 10.1128/Jvi.74.16.7338-7348.2000  0.35
2000 Kurys G, Tagaya Y, Bamford R, Hanover JA, Waldmann TA. The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15. The Journal of Biological Chemistry. 275: 30653-9. PMID 10869346 DOI: 10.1074/Jbc.M002373200  0.348
2000 Vereb G, Matkó J, Vámosi G, Ibrahim SM, Magyar E, Varga S, Szöllősi J, Jenei A, Gáspár R, Waldmann TA, Damjanovich S. Cholesterol-dependent clustering of IL-2Rα and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts Proceedings of the National Academy of Sciences of the United States of America. 97: 6013-6018. PMID 10823948 DOI: 10.1073/Pnas.97.11.6013  0.347
2000 Kreitman RJ, Wilson WH, White JD, Stetler-Stevenson M, Jaffe ES, Giardina S, Waldmann TA, Pastan I. Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 18: 1622-36. PMID 10764422 DOI: 10.1200/Jco.2000.18.8.1622  0.303
2000 Waldmann TA. T-cell receptors for cytokines: Targets for immunotherapy of leukemia/lymphoma Annals of Oncology. 11: 101-106. DOI: 10.1093/Annonc/11.Suppl_1.S101  0.457
1999 Kobayashi H, Tagaya Y, Han ES, Kim IS, Le N, Paik CH, Pastan I, Nelson DL, Waldmann TA, Carrasquillo JA. Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of interleukin-2. Cytokine. 11: 1065-75. PMID 10623432 DOI: 10.1006/Cyto.1999.0509  0.399
1999 Kreitman RJ, Wilson WH, Robbins D, Margulies I, Stetler-Stevenson M, Waldmann TA, Pastan I. Responses in refractory hairy cell leukemia to a recombinant immunotoxin. Blood. 94: 3340-8. PMID 10552943 DOI: 10.1182/Blood.V94.10.3340.422K19_3340_3348  0.355
1999 Nussenblatt RB, Fortin E, Schiffman R, Rizzo L, Smith J, Veldhuisen PV, Sran P, Yaffe A, Goldman CK, Waldmann TA, Whitcup SM. Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: A phase I/II clinical trial Proceedings of the National Academy of Sciences of the United States of America. 96: 7462-7466. PMID 10377437 DOI: 10.1073/Pnas.96.13.7462  0.369
1999 Azimi N, Tagaya Y, Waldmann TA. Molecular Mechanism of IL-15 Gene Regulation in HTLV-I Infected Cells: Role of NF-κB and IRF-1 Journal of Acquired Immune Deficiency Syndromes. 20. DOI: 10.1097/00042560-199904010-00105  0.352
1999 Azimi N, Tagaya Y, Jacobson S, Waldmann T. Human T-Cell Lymphotropic Virus-I Tax Protein Transactivates Il-2 And Il-15 Gene Transcription: Pathogenic Implications And Rationale For Immunotherapy. Journal of Acquired Immune Deficiency Syndromes. 20. DOI: 10.1097/00042560-199904010-00018  0.304
1998 WEISSMAN SM, WALDMANN TA, BERLIN NI. Quantitative measurement of erythropoiesis in the dog. The American Journal of Physiology. 198: 183-6. PMID 13843788 DOI: 10.1152/Ajplegacy.1960.198.1.183  0.303
1998 Lehky TJ, Levin MC, Kubota R, Bamford RN, Flerlage AN, Soldan SS, Leist TP, Xavier A, White JD, Brown M, Fleisher TA, Top LE, Light S, McFarland HF, Waldmann TA, et al. Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac. Annals of Neurology. 44: 942-7. PMID 9851439 DOI: 10.1002/Ana.410440613  0.371
1998 Waldmann TA, O'Shea J. The use of antibodies against the IL-2 receptor in transplantation. Current Opinion in Immunology. 10: 507-512. PMID 9794841 DOI: 10.1016/S0952-7915(98)80215-X  0.397
1998 Kingsbury G, Waldmann T, Junghans R. Examination of a role for idiotypy in the disease remission of a long-term survivor of adult T cell leukemia treated with anti-Tac antibody. Leukemia. 12: 982-991. PMID 9639430 DOI: 10.1038/Sj.Leu.2401048  0.344
1998 Migone TS, Cacalano NA, Taylor N, Yi T, Waldmann TA, Johnston JA. Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells Proceedings of the National Academy of Sciences of the United States of America. 95: 3845-3850. PMID 9520455 DOI: 10.1073/Pnas.95.7.3845  0.412
1998 Ogasawara K, Hida S, Azimi N, Tagaya Y, Sato T, Yokochi-Fukuda T, Waldmann TA, Taniguchi T, Taki S. Requirement for IRF-1 in the microenvironment supporting development of natural killer cells. Nature. 391: 700-3. PMID 9490414 DOI: 10.1038/35636  0.331
1998 Azimi N, Brown K, Bamford RN, Tagaya Y, Siebenlist U, Waldmann TA. Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site. Proceedings of the National Academy of Sciences of the United States of America. 95: 2452-7. PMID 9482906 DOI: 10.1073/Pnas.95.5.2452  0.445
1998 Schwarz UP, Plascjak P, Beitzel MP, Gansow OA, Eckelman WC, Waldmann TA. Preparation of 211At-labeled humanized anti-Tac using 211At produced in disposable internal and external bismuth targets. Nuclear Medicine and Biology. 25: 89-93. PMID 9468021 DOI: 10.1016/S0969-8051(97)00165-0  0.307
1998 Junghans RP, Carrasquillo JA, Waldmann TA. Impact of antigenemia on the bioactivity of infused anti-Tac antibody: Implications for dose selection in antibody immunotherapies Proceedings of the National Academy of Sciences of the United States of America. 95: 1752-1757. PMID 9465089 DOI: 10.1073/Pnas.95.4.1752  0.349
1998 Ogasawara K, Hida S, Azimi N, Tagaya Y, Sato T, Yokochi-Fukuda T, Waldmann TA, Taniguchi T, Taki S. Erratum: Requirement for IRF-1 in the microenvironment supporting development of natural killer cells: correction Nature. 392: 843-843. DOI: 10.1038/33977  0.31
1997 Tagaya Y, Kurys G, Thies TA, Losi JM, Azimi N, Hanover JA, Bamford RN, Waldmann TA. Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides. Proceedings of the National Academy of Sciences of the United States of America. 94: 14444-9. PMID 9405632 DOI: 10.1073/Pnas.94.26.14444  0.301
1997 Damjanovich S, Bene L, Matkó J, Alileche A, Goldman CK, Sharrow S, Waldmann TA. Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study Proceedings of the National Academy of Sciences of the United States of America. 94: 13134-13139. PMID 9371812 DOI: 10.1073/Pnas.94.24.13134  0.397
1997 Richardson JH, Waldmann TA, Sodroski JG, Marasco WA. Inducible knockout of the interleukin-2 receptor α chain: Expression of the high-affinity IL-2 receptor is not required for the in vitro growth of HTLV-I-transformed cell lines Virology. 237: 209-216. PMID 9356333 DOI: 10.1006/Viro.1997.8779  0.439
1997 Hartmann F, Horak EM, Cho C, Lupu R, Bolen JB, Stetler-Stevenson MA, Pfreundschuh M, Waldmann TA, Horak ID. Effects of the tyrosine-kinase inhibitor geldanamycin on ligand-induced Her-2/neu activation, receptor expression and proliferation of Her-2-positive malignant cell lines. International Journal of Cancer. Journal International Du Cancer. 70: 221-9. PMID 9009164 DOI: 10.1002/(Sici)1097-0215(19970117)70:2<221::Aid-Ijc14>3.0.Co;2-L  0.303
1996 Junghans RP, Waldmann TA. Metabolism of Tac (IL2Ralpha): physiology of cell surface shedding and renal catabolism, and suppression of catabolism by antibody binding. Journal of Experimental Medicine. 183: 1587-1602. PMID 8666917 DOI: 10.1084/Jem.183.4.1587  0.404
1996 Bamford RN, Battiata AP, Waldmann TA. Il-15 : The Role Of Translational Regulation In Their Expression Journal of Leukocyte Biology. 59: 476-480. PMID 8613692 DOI: 10.1002/Jlb.59.4.476  0.397
1996 Tagaya Y, Bamford RN, DeFilippis AP, Waldmann TA. IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity. 4: 329-336. PMID 8612127 DOI: 10.1016/S1074-7613(00)80246-0  0.334
1996 Bamford RN, Battiata AP, Burton JD, Sharma H, Waldmann TA. Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation. Proceedings of the National Academy of Sciences of the United States of America. 93: 2897-902. PMID 8610139 DOI: 10.1073/Pnas.93.7.2897  0.416
1995 White JD, Zaknoen SL, Kasten-Sportès C, Top LE, Navarro-Roman L, Nelson DL, Waldmann TA. Infectious complications and immunodeficiency in patients with human T‐cell lymphotropic virus I‐associated adult T‐cell leukemia/lymphoma Cancer. 75: 1598-1607. PMID 8826916 DOI: 10.1002/1097-0142(19950401)75:7<1598::Aid-Cncr2820750708>3.0.Co;2-7  0.385
1995 Richardson JH, Sodroski JG, Waldmann TA, Marasco WA. Phenotypic knockout of the high-affinity human interleukin 2 receptor by intracellular single-chain antibodies against the α subunit of the receptor Proceedings of the National Academy of Sciences of the United States of America. 92: 3137-3141. PMID 7724529 DOI: 10.1073/Pnas.92.8.3137  0.431
1995 Waldmann TA. Human T-Cell Lymphotropic Virus Type I—Associated Adult T-Cell Leukemia: The Joseph Goldberger Clinical Investigator Lecture Jama. 273: 735-737. DOI: 10.1001/Jama.1995.03520330065039  0.391
1994 Bamford RN, Grant AJ, Burton JD, Peters C, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA. The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 4940-4. PMID 8197161 DOI: 10.1073/Pnas.91.11.4940  0.428
1994 Burton JD, Bamford RN, Peters C, Grant AJ, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA. A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 4935-9. PMID 8197160 DOI: 10.1073/Pnas.91.11.4935  0.433
1994 Waldmann TA. Lymphokine receptors: A target for immunotherapy of lymphomas Annals of Oncology. 5: 13-17. PMID 8172810 DOI: 10.1093/Annonc/5.Suppl_1.S13  0.423
1994 Roessler E, Grant A, Ju G, Tsudo M, Sugamura K, Waldmann TA. Cooperative interactions between the interleukin 2 receptor alpha and beta chains alter the interleukin 2-binding affinity of the receptor subunits. Proceedings of the National Academy of Sciences of the United States of America. 91: 3344-7. PMID 8159750 DOI: 10.1073/Pnas.91.8.3344  0.34
1994 Gale RP, Waldmann TA, Armitage JO, Cavalli F. Recent progress in B- and T-cell lymphomas Annals of Oncology. 5: 689-696. PMID 7826900 DOI: 10.1093/Oxfordjournals.Annonc.A058970  0.361
1994 Anasetti C, Hansen J, Waldmann T, Appelbaum F, Davis J, Deeg H, Doney K, Martin P, Nash R, Storb R. Treatment of acute graft-versus-host disease with humanized Anti-Tac : an antibody that binds to the interleukin-2 receptor Blood. 84: 1320-1327. DOI: 10.1182/Blood.V84.4.1320.Bloodjournal8441320  0.392
1994 Kasten-Sportes C, Zaknoen S, Steis R, Chan W, Winton E, Waldmann T. T-cell receptor gene rearrangement in T-cell large granular leukocyte leukemia: preferential V alpha but diverse J alpha usage in one of five patients Blood. 83: 767-775. DOI: 10.1182/Blood.V83.3.767.767  0.341
1993 Waldmann TA. The IL-2/IL-2 receptor system: a target for rational immune intervention Immunology Today. 14: 264-270. PMID 8397768 DOI: 10.1016/0167-5699(93)90043-K  0.389
1993 Waldmann TA. The IL-2/IL-2 receptor system: a target for rational immune intervention Trends in Pharmacological Sciences. 14: 159-164. PMID 8212311 DOI: 10.1016/0165-6147(93)90201-T  0.388
1993 Waldmann T, White J, Goldman C, Top L, Grant A, Bamford R, Roessler E, Horak I, Zaknoen S, Kasten-Sportes C. The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia Blood. 82: 1701-1712. DOI: 10.1182/Blood.V82.6.1701.1701  0.467
1993 Debatin KM, Goldman CK, Waldmann TA, Krammer PH. APO-1-induced apoptosis of leukemia cells from patients with adult T-cell leukemia. Blood. 81: 2972-2977. DOI: 10.1182/Blood.V81.11.2972.Bloodjournal81112972  0.396
1992 Waldmann TA, Pastan IH, Gansow OA, Junghans RP. The multichain interleukin-2 receptor: a target for immunotherapy. Annals of Internal Medicine. 116: 148-60. PMID 1727619 DOI: 10.7326/0003-4819-116-2-148  0.452
1992 Waldmann TA. Immune Receptors: Targets for Therapy of Leukemia/Lymphoma, Autoimmune Diseases and for the Prevention of Allograft Rejection Annual Review of Immunology. 10: 675-704. PMID 1590999 DOI: 10.1146/Annurev.Iy.10.040192.003331  0.371
1992 Grant AJ, Roessler E, Ju G, Tsudo M, Sugamura K, Waldmann TA. The interleukin 2 receptor (IL-2R): the IL-2R alpha subunit alters the function of the IL-2R beta subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R alpha subunit. Proceedings of the National Academy of Sciences of the United States of America. 89: 2165-9. PMID 1549576 DOI: 10.1073/Pnas.89.6.2165  0.347
1992 Parenteau GL, Dirbas FM, Garmestani K, Brechbiel MW, Bukowski MA, Goldman CK, Clark R, Gansow OA, Waldmann TA. Prolongation of graft survival in primate allograft transplantation by yttrium-90-labeled anti-Tac in conjunction with granulocyte colony-stimulating factor. Transplantation. 54: 963-8. PMID 1281566 DOI: 10.1097/00007890-199212000-00004  0.335
1991 Waldmann T. Monoclonal antibodies in diagnosis and therapy. Science. 252: 1657-1662. PMID 2047874 DOI: 10.1126/Science.2047874  0.31
1991 Horak ID, Gress RE, Lucas PJ, Horak EM, Waldmann TA, Bolen JB. T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck. Proceedings of the National Academy of Sciences of the United States of America. 88: 1996-2000. PMID 2000405 DOI: 10.1073/Pnas.88.5.1996  0.425
1991 Waldmann TA. Lymphokine receptor-directed therapy: a model for immune intervention in leukemia, autoimmunity, and immunodeficiency. Clinical Immunology and Immunopathology. 61. PMID 1934612 DOI: 10.1016/S0090-1229(05)80036-4  0.439
1991 Kirkman RL, Shapiro ME, Carpenter CB, McKay DB, Milford EL, Ramos EL, Tilney NL, Waldmann TA, Zimmerman CE, Strom TB. A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation. Transplantation. 51: 107-13. PMID 1846250 DOI: 10.1097/00007890-199101000-00016  0.338
1991 Tendler CL, Greenberg SJ, Burton JD, Danielpour D, Kim SJ, Blattner WA, Manns A, Waldmann TA. Cytokine induction in HTLV-I associated myelopathy and adult T-cell leukemia: alternate molecular mechanisms underlying retroviral pathogenesis. Journal of Cellular Biochemistry. 46: 302-11. PMID 1757474 DOI: 10.1002/Jcb.240460405  0.367
1990 Greenberg SJ, Jaffe ES, Ehrlich GD, Korman NJ, Poiesz BJ, Waldmann TA. Kaposi's sarcoma in human T-cell leukemia virus type I-associated adult T-cell leukemia Blood. 76: 971-976. PMID 2393719 DOI: 10.1182/Blood.V76.5.971.971  0.348
1990 Sanford KK, Parshad R, Price FM, Jones GM, Tarone RE, Eierman L, Hale P, Waldmann TA. Enhanced Chromatid Damage in Blood Lymphocytes After G2 Phase X Irradiation, a Marker of the Ataxia-Telangiectasia Gene Journal of the National Cancer Institute. 82: 1050-1054. PMID 2348470 DOI: 10.1093/Jnci/82.12.1050  0.333
1990 Begley CG, Burton JD, Tsudo M, Brownstein BH, Ambrus JL, Waldmann TA. Human B lymphocytes express the p75 component of the interleukin 2 receptor. Leukemia Research. 14: 263-71. PMID 2319807 DOI: 10.1016/0145-2126(90)90134-U  0.391
1990 Cooper MM, Robbins RC, Goldman CK, Mirzadeh S, Brechbiel MW, Stone CD, Gansow OA, Clark RE, Waldmann TA. Use of yttrium-90-labeled anti-Tac antibody in primate xenograft transplantation. Transplantation. 50: 760-5. PMID 2238051 DOI: 10.1097/00007890-199011000-00005  0.358
1990 Kreitman RJ, Chaudhary VK, Waldmann T, Willingham MC, FitzGerald DJ, Pastan I. The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 87: 8291-5. PMID 2236041 DOI: 10.1073/Pnas.87.21.8291  0.459
1990 Waldmann TA, Grant A, Tendler C, Greenberg S, Goldman C, Bamford R, Junghans RP, Nelson D. Lymphokine receptor-directed therapy: a model of immune intervention. Journal of Clinical Immunology. 10. PMID 2081786 DOI: 10.1007/Bf00918688  0.441
1990 Burton J, Goldman CK, Rao P, Moos M, Waldmann TA. Association of intercellular adhesion molecule 1 with the multichain high-affinity interleukin 2 receptor. Proceedings of the National Academy of Sciences of the United States of America. 87: 7329-7333. PMID 1976256 DOI: 10.1073/Pnas.87.18.7329  0.447
1990 Debatin KM, Krammer PH, Goldman CK, Bamford R, Waldmann TA. Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia. The Lancet. 335: 497-500. PMID 1689786 DOI: 10.1016/0140-6736(90)90735-N  0.399
1990 Wright J, Wagner D, Blaese R, Hagengruber C, Waldmann T, Fleisher T. Characterization of common variable immunodeficiency : identification of a subset of patients with distinctive immunophenotypic and clinical features Blood. 76: 2046-2051. DOI: 10.1182/Blood.V76.10.2046.Bloodjournal76102046  0.4
1990 Waldmann TA. The Multichain Interleukin 2 Receptor A Target for Immunotherapy in Lymphoma, Autoimmune Disorders, and Organ Allografts Jama. 263: 272-274. DOI: 10.1001/Jama.1990.03440020106042  0.379
1989 Wirt DP, Brooks EG, Vaidya S, Klimpel GR, Waldmann TA, Goldblum RM. Novel T-lymphocyte population in combined immunodeficiency with features of graft-versus-host disease New England Journal of Medicine. 321: 370-374. PMID 2787478 DOI: 10.1056/Nejm198908103210606  0.39
1989 Begley CG, Aplan PD, Davey MP, Villartay JPd, Cohen DI, Waldmann TA, Kirsch IR. Demonstration of delta rec-pseudo J alpha rearrangement with deletion of the delta locus in a human stem-cell leukemia. Journal of Experimental Medicine. 170: 339-342. PMID 2746162 DOI: 10.1084/Jem.170.1.339  0.301
1989 Waldmann TA. Disorders of the expression of the multichain IL-2 receptor in HTLV-I-associated adult T-cell leukemia. Haematology and Blood Transfusion. 32: 293-298. PMID 2696683 DOI: 10.1007/978-3-642-74621-5_52  0.446
1989 Green JE, Begley CG, Wagner DK, Waldmann TA, Jay G. trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human T-lymphotropic virus type 1 tax gene. Molecular and Cellular Biology. 9: 4731-7. PMID 2689863 DOI: 10.1128/Mcb.9.11.4731  0.395
1989 Waldmann TA. Multichain Interleukin-2 Receptor: A Target for Immunotherapy in Lymphoma Journal of the National Cancer Institute. 81: 914-923. PMID 2659803 DOI: 10.1093/Jnci/81.12.914  0.426
1989 Reed MH, Shapiro ME, Strom TB, Milford EL, Carpenter CB, Weinberg DS, Reimann KA, Letvin NL, Waldmann TA, Kirkman RL. Prolongation of primate renal allograft survival by anti-tac, an anti-human IL-2 receptor monoclonal antibody Transplantation. 47: 55-59. PMID 2643232 DOI: 10.1097/00007890-198901000-00013  0.377
1989 Ramos EL, Milford EL, Kirkman RL, Tilney NL, Strom TB, Shapiro ME, Waldmann TA, Wood IG, Rollins MR, Carpenter CB. Differential IL-2 receptor expression in renal allograft recipients treated with an ANTI-IL-2-receptor antibody Transplantation. 48: 415-420. PMID 2571203 DOI: 10.1097/00007890-198909000-00012  0.401
1989 Chan WC, Link S, Srinivasan A, Bamford R, Waldmann TA. A T-cell line with an unusual phenotype. Cancer. 64: 1859-66. PMID 2551476 DOI: 10.1002/1097-0142(19891101)64:9<1859::Aid-Cncr2820640918>3.0.Co;2-W  0.426
1989 Oh-Ishi T, Goldman CK, Misiti J, Waldmann TA. The interaction of interleukin 2 with its receptor in the generation of suppressor T cells in antigen-specific and antigen-nonspecific systems in vitro. Clinical Immunology and Immunopathology. 52: 447-459. PMID 2547539 DOI: 10.1016/0090-1229(89)90159-1  0.468
1989 Greenberg SJ, Jacobson S, Waldmann TA, McFarlin DALEE. Molecular Analysis of Htlv-I Proviral Integration and T Cell Receptor Arrangement Indicates that T Cells in Tropical Spastic Paraparesis are Polyclonal Journal of Infectious Diseases. 159: 741-744. PMID 2538520 DOI: 10.1093/Infdis/159.4.741  0.311
1989 Queen C, Schneider WP, Selick HE, Payne PW, Landolfi NF, Duncan JF, Avdalovic NM, Levitt M, Junghans RP, Waldmann TA. A humanized antibody that binds to the interleukin 2 receptor. Proceedings of the National Academy of Sciences of the United States of America. 86: 10029-33. PMID 2513570 DOI: 10.1073/Pnas.86.24.10029  0.331
1989 Chaudhary VK, Queen C, Junghans RP, Waldmann TA, FitzGerald DJ, Pastan I. A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature. 339: 394-7. PMID 2498664 DOI: 10.1038/339394A0  0.336
1989 Greenberg SJ, Ehrlich GD, Abbott MA, Hurwitz BJ, Waldmann TA, Poiesz BJ. Detection of sequences homologous to human retroviral DNA in multiple sclerosis by gene amplification Proceedings of the National Academy of Sciences of the United States of America. 86: 2878-2882. PMID 2468159 DOI: 10.1073/Pnas.86.8.2878  0.319
1989 Begley CG, Aplan PD, Davey MP, Nakahara K, Tchorz KM, Kurtzberg J, Hershfield MS, Haynes BF, Cohen DI, Waldmann TA, Kirsch IR. Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. Proceedings of the National Academy of Sciences of the United States of America. 86: 2031-2035. PMID 2467296 DOI: 10.1073/Pnas.86.6.2031  0.337
1989 Hege K, Daleke D, Waldmann T, Matthay K. Comparison of anti-Tac and anti-transferrin receptor-conjugated liposomes for specific drug delivery to adult T-cell leukemia Blood. 74: 2043-2052. DOI: 10.1182/Blood.V74.6.2043.Bloodjournal7462043  0.408
1989 Waldmann TA, Goldman C, Tsudo M. The multichain interleukin-2 receptor: from the gene to the bedside. Harvey Lectures. 82: 675-683. DOI: 10.1007/978-1-4613-0753-2_68  0.452
1988 de Villartay JP, Lewis D, Hockett R, Waldmann TA, Korsmeyer SJ, Cohen DI. Deletional rearrangement in the human T-cell receptor alpha-chain locus. Proceedings of the National Academy of Sciences of the United States of America. 84: 8608-12. PMID 3500476 DOI: 10.1073/Pnas.84.23.8608  0.562
1988 Kaulfersch W, Fiocchi C, Waldmann TA. Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease. A molecular genetic evaluation of the immunoglobulin and T-cell antigen receptors. Gastroenterology. 95: 364-370. PMID 3260569 DOI: 10.1016/0016-5085(88)90492-1  0.399
1988 Davey MP, Bertness V, Nakahara K, Johnson JP, McBride OW, Waldmann TA, Kirsch IR. Juxtaposition of the T-cell receptor alpha-chain locus (14q11) and a region (14q32) of potential importance in leukemogenesis by a 14;14 translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia. Proceedings of the National Academy of Sciences of the United States of America. 85: 9287-9291. PMID 3194425 DOI: 10.1073/Pnas.85.23.9287  0.328
1988 Kaulfersch W, Baker JR, Burman KD, Ahmann AJ, D’Avis JC, Waldmann TA. Immunoglobulin and T Cell Antigen Receptor Gene Arrangements Indicate That the Immune Response in Autoimmune Thyroid Disease Is Polyclonal The Journal of Clinical Endocrinology and Metabolism. 66: 958-963. PMID 3129452 DOI: 10.1210/Jcem-66-5-958  0.398
1988 Oh-Ishi T, Goldman CK, Misiti J, Waldmann TA. Blockade of the interleukin-2 receptor by anti-Tac antibody inhibits the generation of antigen-nonspecific suppressor T cells in vitro. Proceedings of the National Academy of Sciences of the United States of America. 85: 6478-6482. PMID 2970641 DOI: 10.1073/Pnas.85.17.6478  0.464
1988 Greenberg SJ, Davey MP, Zierdt WS, Waldmann TA. Isospora belli enteric infection in patients with human T-cell leukemia virus type I-associated adult T-cell leukemia The American Journal of Medicine. 85: 435-438. PMID 2901228 DOI: 10.1016/0002-9343(88)90603-1  0.368
1988 Kaulfersch W, Fiocchi C, Waldmann TA. Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease Gastroenterology. 95: 364-370. DOI: 10.5555/Uri:Pii:0016508588904921  0.393
1988 Waldmann T, Goldman C, Bongiovanni K, Sharrow S, Davey M, Cease K, Greenberg S, Longo D. Therapy of patients with human T-cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2 Blood. 72: 1805-1816. DOI: 10.1182/Blood.V72.5.1805.Bloodjournal7251805  0.471
1988 Sheridan W, Winton E, Chan W, Gordon D, Vogler W, Phillips C, Bongiovanni K, Waldmann T. Leukemia of non-T lineage natural killer cells Blood. 72: 1701-1707. DOI: 10.1182/Blood.V72.5.1701.Bloodjournal7251701  0.391
1988 Chan W, Dahl C, Waldmann T, Mawle A, Nicholson J, Bach F, Bongiovanni K, McCue P, Winton E. Large granular lymphocyte proliferation: an analysis of T-cell receptor gene arrangement and expression and the effect of in vitro culture with inducing agents Blood. 71: 52-58. DOI: 10.1182/Blood.V71.1.52.Bloodjournal71152  0.421
1988 OWEN-SCHAUB L, YAGITA M, TSUDO M, WALDMANN TA, GRIMM EA. Evidence for Distinct IL-2 Receptors in Induction versus Maintenance of LAK Function Annals of the New York Academy of Sciences. 532: 480-481. DOI: 10.1111/J.1749-6632.1988.Tb36382.X  0.351
1988 Waldmann TA. The multichain interleukin-2-receptor: A target for immunotherapy of patients with adult T-cell leukemia, autoimmune disorders and individuals receiving allografts Journal of Autoimmunity. 1: 641-653. DOI: 10.1016/0896-8411(88)90055-8  0.44
1987 Waldmann TA, Kozak RW, Tsudo M, Oh-ishi T, Bongiovanni KF, Goldman CK. IL-2 receptors in adult T-cell leukemia: a target for immunotherapy. Haematology and Blood Transfusion. 31: 110-5. PMID 3127278 DOI: 10.1007/978-3-642-72624-8_23  0.457
1987 Tsudo M, Goldman CK, Bongiovanni KF, Chan WC, Winton EF, Yagita M, Grimm EA, Waldmann TA. The p75 peptide is the receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 5394-8. PMID 3110786 DOI: 10.1073/Pnas.84.15.5394  0.381
1987 Waldmann TA. The arrangement of immunoglobulin and T cell receptor genes in human lymphoproliferative disorders Advances in Immunology. 40: 247-321. PMID 3109221 DOI: 10.1016/S0065-2776(08)60241-2  0.439
1987 Tsudo M, Kozak RW, Goldman CK, Waldmann TA. Contribution of a p75 interleukin 2 binding peptide to a high-affinity interleukin 2 receptor complex. Proceedings of the National Academy of Sciences of the United States of America. 84: 4215-8. PMID 3108887 DOI: 10.1073/Pnas.84.12.4215  0.335
1987 Bakhshi A, Guglielmi P, Coligan JE, Gamza F, Waldmann TA, Korsmeyer SJ. A pre-translational defect in a case of human mu heavy chain disease. Molecular Immunology. 23: 725-32. PMID 3099178 DOI: 10.1016/0161-5890(86)90083-0  0.513
1987 Waldmann TA. The role of the multichain IL-2 receptor complex in the control of normal and malignant T-cell proliferation. Environmental Health Perspectives. 75: 11-15. PMID 2891501 DOI: 10.1289/Ehp.877511  0.436
1987 Waldmann TA. The Interleukin-2 Receptor on Normal and Malignant Lymphocytes Advances in Experimental Medicine and Biology. 213: 129-137. PMID 2888269 DOI: 10.1007/978-1-4684-5323-2_13  0.454
1987 Szollosi J, Damjanovich S, Goldman CK, Fulwyler MJ, Aszalos AA, Goldstein G, Rao P, Talle MA, Waldmann TA. Flow cytometric resonance energy transfer measurements support the association of a 95-kDa peptide termed T27 with the 55-kDa Tac peptide. Proceedings of the National Academy of Sciences of the United States of America. 84: 7246-7250. PMID 2444977 DOI: 10.1073/Pnas.84.20.7246  0.335
1986 Davey MP, Waldmann TA. Clonality and Lymphoproliferative Lesions The New England Journal of Medicine. 315: 509-511. PMID 3488504 DOI: 10.1056/Nejm198608213150809  0.312
1986 Davey MP, Bongiovanni KF, Kaulfersch W, Quertermous T, Seidman JG, Hershfield MS, Kurtzberg J, Haynes BF, Davis MM, Waldmann TA. Immunoglobulin and T-cell receptor gene rearrangement and expression in human lymphoid leukemia cells at different stages of maturation. Proceedings of the National Academy of Sciences of the United States of America. 83: 8759-63. PMID 3464980 DOI: 10.1073/Pnas.83.22.8759  0.426
1986 Tsudo M, Kozak RW, Goldman CK, Waldmann TA. Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex. Proceedings of the National Academy of Sciences of the United States of America. 83: 9694-8. PMID 3099289 DOI: 10.1073/Pnas.83.24.9694  0.395
1986 Waldmann TA. Immunodeficiency: immunoregulation and immunogenetics. Clinical Immunology and Immunopathology. 40: 25-36. PMID 3087667 DOI: 10.1016/0090-1229(86)90066-8  0.413
1986 Weissman AM, Harford JB, Svetlik PB, Leonard WL, Depper JM, Waldmann TA, Greene WC, Klausner RD. Only high-affinity receptors for interleukin 2 mediate internalization of ligand. Proceedings of the National Academy of Sciences of the United States of America. 83: 1463-6. PMID 3081898 DOI: 10.1073/Pnas.83.5.1463  0.424
1986 Kozak RW, Atcher RW, Gansow OA, Friedman AM, Hines JJ, Waldmann TA. Bismuth-212-labeled anti-Tac monoclonal antibody: alpha-particle-emitting radionuclides as modalities for radioimmunotherapy. Proceedings of the National Academy of Sciences of the United States of America. 83: 474-8. PMID 3079913 DOI: 10.1073/Pnas.83.2.474  0.402
1986 Waldmann TA. The interleukin-2 receptor on malignant cells: a target for diagnosis and therapy. Cellular Immunology. 99: 53-60. PMID 3019574 DOI: 10.1016/0008-8749(86)90215-7  0.467
1986 Greene WC, Leonard WJ, Depper JM, Nelson DL, Waldmann TA. The human interleukin-2 receptor: normal and abnormal expression in T cells and in leukemias induced by the human T-lymphotropic retroviruses. Annals of Internal Medicine. 105: 560-72. PMID 3019203 DOI: 10.7326/0003-4819-105-4-560  0.417
1986 Waldmann TA. The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes. Science. 232: 727-732. PMID 3008337 DOI: 10.1126/Science.3008337  0.469
1986 Winton E, Chan W, Check I, Colenda K, Bongiovanni K, Waldmann T. Spontaneous Regression of a Monoclonal Proliferation of Large Granular Lymphocytes Associated With Reversal of Anemia and Neutropenia Blood. 67: 1427-1432. DOI: 10.1182/Blood.V67.5.1427.Bloodjournal6751427  0.386
1986 Chan WC, Winton EF, Waldmann TA. Lymphocytosis of Large Granular Lymphocytes Jama Internal Medicine. 146: 1201-1203. DOI: 10.1001/Archinte.1986.00360180219032  0.397
1985 Korsmeyer SJ, Bakhshi A, Arnold A, Siminovitch KA, Waldmann TA. Human B-cell precursor leukemias. Survey and Synthesis of Pathology Research. 3: 510-9. PMID 6336010 DOI: 10.1159/000156953  0.545
1985 Waldmann TA, Korsmeyer SJ, Bakhshi A, Arnold A, Kirsch IR. NIH conference. Molecular genetic analysis of human lymphoid neoplasms. Immunoglobulin genes and the c-myc oncogene. Annals of Internal Medicine. 102: 497-510. PMID 3919627 DOI: 10.7326/0003-4819-102-4-497  0.564
1985 Murre C, Waldmann RA, Morton CC, Bongiovanni KF, Waldmann TA, Shows TB, Seidman JG. Human γ-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7 Nature. 316: 549-552. PMID 3875797 DOI: 10.1038/316549A0  0.366
1985 Waldmann TA, Davis MM, Bongiovanni KF, Korsmeyer SJ. Rearrangements of genes for the antigen receptor on T cells as markers of lineage and clonality in human lymphoid neoplasms. The New England Journal of Medicine. 313: 776-83. PMID 2993886 DOI: 10.1056/Nejm198509263131303  0.583
1985 Greene WC, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Krönke M, Svetlik P, Peffer NJ, Waldmann TA. Molecular cloning of cDNA for the human interleukin-2 receptor. Haematology and Blood Transfusion. 29: 388-95. PMID 2993133 DOI: 10.1007/978-3-642-70385-0_80  0.447
1985 Depper JM, Leonard WJ, Drogula C, Krönke M, Waldmann TA, Greene WC. Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. Proceedings of the National Academy of Sciences of the United States of America. 82: 4230-4. PMID 2987968 DOI: 10.1073/Pnas.82.12.4230  0.384
1985 Krönke M, Depper JM, Leonard WJ, Vitetta ES, Waldmann TA, Greene WC. Adult T cell leukemia: a potential target for ricin A chain immunotoxins. Blood. 65: 1416-21. PMID 2986744 DOI: 10.1182/Blood.V65.6.1416.Bloodjournal6561416  0.477
1985 Depper JM, Leonard WJ, Drogula CL, Krönke M, Waldmann TA, Greene WC. Activators of protein kinase C and 5-azacytidine induce IL-2 receptor expression on human T lymphocytes. Journal of Cellular Biochemistry. 27: 267-76. PMID 2580852 DOI: 10.1002/Jcb.240270308  0.384
1985 Kronke M, Depper J, Leonard W, Vitetta E, Waldmann T, Greene W. Adult T cell leukemia: a potential target for ricin A chain immunotoxins Blood. 65: 1416-1421. DOI: 10.1182/blood.v65.6.1416.bloodjournal6561416  0.374
1984 Mingari MC, Gerosa F, Carra G, Accolla RS, Moretta A, Zubler RH, Waldmann TA, Moretta L. Human interleukin-2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cells. Nature. 312: 641-3. PMID 6438535 DOI: 10.1038/312641A0  0.479
1984 FitzGerald DJ, Waldmann TA, Willingham MC, Pastan I. Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor. Journal of Clinical Investigation. 74: 966-971. PMID 6432853 DOI: 10.1172/Jci111516  0.382
1984 Korsmeyer SJ, Waldmann TA. Immunoglobulin genes: rearrangement and translocation in human lymphoid malignancy. Journal of Clinical Immunology. 4: 1-11. PMID 6421869 DOI: 10.1007/Bf00915280  0.523
1984 Leonard WJ, Depper JM, Robb RJ, Waldmann TA, Greene WC. Characterization of the human receptor for T-cell growth factor. Proceedings of the National Academy of Sciences of the United States of America. 80: 6957-61. PMID 6417659 DOI: 10.1073/Pnas.80.22.6957  0.373
1984 Arnold A, Cossman J, Bakhshi A, Jaffe ES, Waldmann TA, Korsmeyer SJ. Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. The New England Journal of Medicine. 309: 1593-9. PMID 6417538 DOI: 10.1056/Nejm198312293092601  0.57
1984 Krönke M, Leonard WJ, Depper JM, Arya SK, Wong-Staal F, Gallo RC, Waldmann TA, Greene WC. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proceedings of the National Academy of Sciences of the United States of America. 81: 5214-8. PMID 6332315 DOI: 10.1073/Pnas.81.16.5214  0.364
1984 Waldmann TA, Greene WC, Sarin PS, Saxinger C, Blayney DW, Blattner WA, Goldman CK, Bongiovanni K, Sharrow S, Depper JM. Functional and phenotypic comparison of human T cell leukemia/lymphoma virus positive adult T cell leukemia with human T cell leukemia/lymphoma virus negative Sézary leukemia, and their distinction using anti-Tac. Monoclonal antibody identifying the human receptor for T cell growth factor. The Journal of Clinical Investigation. 73: 1711-8. PMID 6327770 DOI: 10.1172/Jci111379  0.42
1984 Broder S, Bunn PA, Jaffe ES, Blattner W, Gallo RC, Wong-Staal F, Waldmann TA, DeVITA VT. T-Cell Lymphoproliferative Syndrome Associated with Human T-Cell Leukemia/Lymphoma Virus Annals of Internal Medicine. 100: 543-557. PMID 6322632 DOI: 10.7326/0003-4819-100-4-543  0.381
1984 Waldmann TA, Goldman CK, Leonard WJ, Depper JM, Robb RJ, Korsmeyer SJ, Greene WC. Interleukin-2 receptors on activated malignant and normal B-cells. Current Topics in Microbiology and Immunology. 113: 96-101. PMID 6236954 DOI: 10.1007/978-3-642-69860-6_18  0.611
1984 Waldmann TA, Goldman CK, Robb RJ, Depper JM, Leonard WJ, Sharrow SO, Bongiovanni KF, Korsmeyer SJ, Greene WC. Expression of interleukin 2 receptors on activated human B cells. The Journal of Experimental Medicine. 160: 1450-66. PMID 6092511 DOI: 10.1084/Jem.160.5.1450  0.624
1984 Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Krönke M, Svetlik PB, Peffer NJ, Waldmann TA. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature. 311: 626-31. PMID 6090948 DOI: 10.1038/311626A0  0.33
1984 Korsmeyer SJ, Greene WC, Waldmann TA. Cellular origin of hairy cell leukemia: malignant B cells that express receptors for T cell growth factor. Seminars in Oncology. 11: 394-400. DOI: 10.5555/Uri:Pii:0093775484900836  0.386
1983 Waldmann TA, Broder S, Goldman CK, Frost K, Korsmeyer SJ, Medici MA. Disorders of B cells and helper T cells in the pathogenesis of the immunoglobulin deficiency of patients with ataxia telangiectasia. The Journal of Clinical Investigation. 71: 282-95. PMID 6822665 DOI: 10.1172/Jci110768  0.595
1983 Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC. A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature. 300: 267-9. PMID 6815536 DOI: 10.1038/300267A0  0.399
1983 Bakhshi A, Minowada J, Arnold A, Cossman J, Jensen JP, Whang-Peng J, Waldmann TA, Korsmeyer SJ. Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors. The New England Journal of Medicine. 309: 826-31. PMID 6412140 DOI: 10.1056/Nejm198310063091404  0.558
1983 Korsmeyer SJ, Arnold A, Bakhshi A, Ravetch JV, Siebenlist U, Hieter PA, Sharrow SO, LeBien TW, Kersey JH, Poplack DG, Leder P, Waldmann TA. Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. The Journal of Clinical Investigation. 71: 301-13. PMID 6401769 DOI: 10.1172/Jci110770  0.664
1983 Taub RA, Hollis GF, Hieter PA, Korsmeyer S, Waldmann TA, Leder P. Variable amplification of immunoglobulin lambda light-chain genes in human populations. Nature. 304: 172-4. PMID 6306474 DOI: 10.1038/304172A0  0.614
1983 Lum LG, Benveniste E, Steinberg AD, Waldmann TA, Blaese RM. The proportion of TA, TG, and TM cells in various immunodeficiency and autoimmune disorders Cellular Immunology. 80: 105-114. PMID 6223712 DOI: 10.1016/0008-8749(83)90098-9  0.378
1983 Korsmeyer SJ, Greene WC, Cossman J, Hsu SM, Jensen JP, Neckers LM, Marshall SL, Bakhshi A, Depper JM, Leonard WJ, Jaffe ES, Waldmann TA. Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 80: 4522-6. PMID 6192435 DOI: 10.1073/Pnas.80.14.4522  0.61
1982 Korsmeyer SJ, Hieter PA, Sharrow SO, Goldman CK, Leder P, Waldmann TA. Normal human B cells display ordered light chain gene rearrangements and deletions. The Journal of Experimental Medicine. 156: 975-85. PMID 6818320 DOI: 10.1084/Jem.156.4.975  0.651
1982 Waldmann TA, Broder S. Polyclonal B-cell activators in the study of the regulation of immunoglobulin synthesis in the human system. Advances in Immunology. 32: 1-63. PMID 6287820 DOI: 10.1016/S0065-2776(08)60720-8  0.416
1982 Korsmeyer SJ, Elfenbein GJ, Goldman CK, Marshall SL, Santos GW, Waldmann TA. B cell, helper T cell, and suppressor T cell abnormalities contribute to disordered immunoglobulin synthesis in patients following bone marrow transplantation. Transplantation. 33: 184-90. PMID 6277055 DOI: 10.1097/00007890-198202000-00015  0.596
1982 Depper J, Leonard W, Uchiyama T, Smith K, Waldmann T, Greene W. A monoclonal antibody, anti-Tac, blocks the action and membrane binding of human interleukin-2 (IL-2) Cellular Immunology. 70: 381. DOI: 10.1016/0008-8749(82)90343-4  0.351
1981 Siebenlist U, Ravetch JV, Korsmeyer S, Waldmann T, Leder P. Human immunoglobulin D segments encoded in tandem multigenic families. Nature. 294: 631-5. PMID 7312051 DOI: 10.1038/294631A0  0.597
1981 Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P. Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. Nature. 290: 368-72. PMID 6783958 DOI: 10.1038/290368A0  0.639
1981 Fleisher TA, Greene WC, Uchiyama T, Goldman CK, Nelson DL, Blaese RM, Waldmann TA. Characterization of a soluble suppressor of human B cell immunoglobulin biosynthesis produced by a continuous human suppressor T cell line. The Journal of Experimental Medicine. 154: 156-67. PMID 6454754 DOI: 10.1084/Jem.154.1.156  0.412
1981 Broder S, Uchiyama T, Muul LM, Goldman C, Sharrow S, Poplack DG, Waldmann TA. Activation of leukemic pro-suppressor cells to become suppressor-effector cells. Influence of cooperating normal T cells. The New England Journal of Medicine. 304: 1382-1387. PMID 6453293 DOI: 10.1056/Nejm198106043042302  0.414
1981 Korsmeyer SJ, Hieter PA, Ravetch JV, Poplack DG, Waldmann TA, Leder P. Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 7096-100. PMID 6273911 DOI: 10.1073/Pnas.78.11.7096  0.664
1981 Hieter PA, Hollis GF, Korsmeyer SJ, Waldmann TA, Leder P. Clustered arrangement of immunoglobulin lambda constant region genes in man. Nature. 294: 536-40. PMID 6273747 DOI: 10.1038/294536A0  0.612
1981 Misiti J, Waldmann TA. In Vitro Generation Of Antigen-Specific Hemolytic Plaque-Forming Cells From Human Peripheral Blood Mononuclear Cells Journal of Experimental Medicine. 154: 1069-1084. PMID 6169779 DOI: 10.1084/Jem.154.4.1069  0.381
1981 Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P. Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes. Cell. 27: 583-91. PMID 6101209 DOI: 10.1016/0092-8674(81)90400-1  0.581
1981 Leder P, Heiter P, Kirsch I, Korsmeyer S, Ravetch J, Waldmann T. HUMAN IMMUNOGLOBULIN GENES: THE ONTOGENY OF SOMATIC REARRANGEMENTS Biochemical Society Transactions. 9: 82P-82P. DOI: 10.1042/Bst009082P  0.618
1981 Broder S, Callihan TR, Jaffe ES, DeVita VT, Strober W, Bartter FC, Waldmann TA. Resolution of longstanding protein-losing enteropathy in a patient with intestinal lymphangiectasia after treatment for malignant lymphoma Gastroenterology. 80: 166-168. DOI: 10.1016/0016-5085(81)90208-0  0.308
1980 Broder S, Muul L, Marshall S, Waldmann TA. Neoplasms of Immunoregulatory T Cells in Clinical Investigation Journal of Investigative Dermatology. 74: 267-271. PMID 6967093 DOI: 10.1111/1523-1747.Ep12543356  0.398
1980 Broder S, Mann DL, Waldmann TA. Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30). Journal of Experimental Medicine. 151: 257-262. PMID 6444235 DOI: 10.1084/Jem.151.1.257  0.414
1980 Gmelig-Meyling F, Waldmann TA. Separation of human blood monocytes and lymphocytes on a continuous percoll gradient Journal of Immunological Methods. 33: 1-9. PMID 6244353 DOI: 10.1016/0022-1759(80)90077-0  0.303
1978 Broder S, Muul L, Waldmann TA. Suppressor Cells in Neoplastic Disease Journal of the National Cancer Institute. 61: 5-11. PMID 353295 DOI: 10.1093/Jnci/61.1.5  0.302
1978 Pichler WJ, Broder S, Muul L, Magrath I, Waldmann TA. Fc IgM receptors on human lymphoblastoid B cell lines European Journal of Immunology. 8: 274-278. PMID 307492 DOI: 10.1002/Eji.1830080411  0.395
1978 Krakauer RS, Strober W, Waldmann TA. Loss of suppressor T cells in the pathogenesis of the autoimmunity of NZB/W mice Arthritis and Rheumatism. 21. PMID 307391 DOI: 10.1002/Art.1780210931  0.363
1978 Waldmann TA, Blaese RM, Broder S, Krakauer RS. Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity Annals of Internal Medicine. 88: 226-238. PMID 305222 DOI: 10.7326/0003-4819-88-2-226  0.388
1978 Broder S, Poplack D, Whang-Peng J, Durm M, Goldman C, Muul L, Waldmann TA. Characterization of a suppressor-cell leukemia. Evidence for the requirement of an interaction of two T cells in the development of human suppressor effector cells. The New England Journal of Medicine. 298: 66-72. PMID 304175 DOI: 10.1056/Nejm197801122980202  0.411
1978 Javadpour N, McIntire KR, Waldmann TA. Human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) in sera and tumor cells of patients with testicular seminoma. A prospective study Cancer. 42: 2768-2772. PMID 83187 DOI: 10.1002/1097-0142(197812)42:6<2768::Aid-Cncr2820420636>3.0.Co;2-Z  0.313
1978 Lawrence E, Broder S, Jaffe E, Braylan R, Dobbins W, Young R, Waldmann T. Evolution of a lymphoma with helper T cell characteristics in Sézary syndrome. Blood. 52: 481-492. DOI: 10.1182/Blood.V52.3.481.Bloodjournal523481  0.355
1978 Waldmann TA, Broder S. T Cell Disorders in Primary Immunodeficiency Diseases Springer Seminars in Immunopathology. 1: 5-30. DOI: 10.1007/978-3-642-81362-7_2  0.393
1977 Krakauer RS, Strober D L Rippeon W, Waldmann TA. Prevention of autoimmunity in experimental lupus erythematosus by soluble immune response suppressor Science. 196: 56-59. PMID 300174 DOI: 10.1126/Science.300174  0.303
1977 Seegmiller JE, Watanabe T, Shreier MH, Waldmann TA. Immunological aspects of purine metabolism. Advances in Experimental Medicine and Biology. 76: 412-33. PMID 193375 DOI: 10.1007/978-1-4613-4223-6_53  0.326
1977 Scardino PT, Cox HD, Waldmann TA, Mcintire KR, Mittemeyer B, Javadpour N. The value of serum tumor markers in the staging and prognosis of germ cell tumors of the testis. The Journal of Urology. 118: 994-999. PMID 72833 DOI: 10.1016/S0022-5347(17)58275-0  0.304
1977 Broder S, Lawrence E, Durn M, Goldman C, Muul L, Waldmann TA. Further Characterization Of Neoplastic Helper T Cells From Patients With The Sézary Syndrome Regulatory Mechanisms in Lymphocyte Activation. 689-691. DOI: 10.1016/B978-0-12-458050-3.50130-2  0.388
1977 Waldmann TA, Broder S, Krakauer R, Durm M, Goldman C, Meade B, Strober W. Dysfunction Of Suppressor Mechanisms Associated With Immunodeficiency And Autoimmunity Regulatory Mechanisms in Lymphocyte Activation. 269-287. DOI: 10.1016/B978-0-12-458050-3.50019-9  0.36
1976 Krakauer RS, Waldmann TA, Strober W. Loss of suppressor T cells in adult NZB/NZW mice. Journal of Experimental Medicine. 144: 662-673. PMID 1085336 DOI: 10.1084/Jem.144.3.662  0.348
1976 Buckley RH, Gilbertsen RB, Schiff RI, Ferreira E, Sanal SO, Waldmann TA. Heterogeneity of lymphocyte subpopulations in severe combined immunodeficiency. Evidence against a stem cell defect. Journal of Clinical Investigation. 58: 130-136. PMID 1084354 DOI: 10.1172/Jci108441  0.404
1976 Korsmeyer SJ, Strickland RG, Ammann AJ, Waldmann TA, Williams RC. Differential specificity of lymphocytotoxins from patients with systemic lupus erythematosus and inflammatory bowel disease. Clinical Immunology and Immunopathology. 5: 67-73. PMID 1083322 DOI: 10.1016/0090-1229(76)90150-1  0.585
1976 Broder S, Edelson RL, Lutzner MA, Nelson DL, MacDermott RP, Durm ME, Goldman CK, Meade BD, Waldmann TA. The Sézary syndrome: a malignant proliferation of helper T cells. Journal of Clinical Investigation. 58: 1297-1306. PMID 136454 DOI: 10.1172/Jci108585  0.422
1976 Boxel JAv, Broder S, Waldmann TA. SUPPRESSION OF IMMUNOGLOBULIN SYNTHESIS IN VITRO BY PURIFIED ANTIBODY TO IgD Leukocyte Membrane Determinants Regulating Immune Reactivity. 297-301. DOI: 10.1016/B978-0-12-233750-5.50054-3  0.332
1974 Waldmann TA, Broder S, Blaese RM, Durm M, Blackman M, Strober W. Role Of Suppressor T Cells In Pathogenesis Of Common Variable Hypogammaglobulinæmia The Lancet. 304: 609-613. PMID 4137918 DOI: 10.1016/S0140-6736(74)91940-0  0.4
1972 Weiden PL, Blaese RM, Strober W, Block JB, Waldmann TA. Impaired lymphocyte transformation in intestinal lymphangiectasia: evidence for at least two functionally distinct lymphocyte populations in man Journal of Clinical Investigation. 51: 1319-1325. PMID 4554185 DOI: 10.1172/Jci106928  0.331
1972 Blaese RM, Oppenheim JJ, Seeger RC, Waldmann TA. Lymphocyte-macrophage interaction in antigen induced in vitro lymphocyte transformation in patients with the Wiskott-Aldrich syndrome and other diseases with anergy. Cellular Immunology. 4: 228-242. PMID 4402568 DOI: 10.1016/0008-8749(72)90027-5  0.322
1971 Waldmann TA, Johnson JS, Talal N. Hypogammaglobulinemia associated with accelerated catabolism of IgG secondary to its inteaction with an IgG-reactive monoclonal IgM. The Journal of Clinical Investigation. 50: 951-9. PMID 4993860 DOI: 10.1172/Jci106567  0.332
1968 Strober W, Wochner RD, Barlow MH, McFarlin DE, Waldmann TA. Immunoglobulin metabolism in ataxia telangiectasia Journal of Clinical Investigation. 47: 1905-1915. PMID 4174353 DOI: 10.1172/Jci105881  0.307
1968 Blaese RM, Strober W, Brown R, Waldmann T. The Wiskott-Aldrich syndrome. A disorder with a possible defect in antigen processing or recognition. The Lancet. 291: 1056-1061. PMID 4172469 DOI: 10.1016/S0140-6736(68)91411-6  0.318
1967 Strober W, Wochner RD, Carbone PP, Waldmann TA. Intestinal Lymphangiectasia: a Protein-Losing Enteropathy with Hypogammaglobulinemia, Lymphocytopenia and Impaired Homograft Rejection Journal of Clinical Investigation. 46: 1643-1656. PMID 4168730 DOI: 10.1172/Jci105656  0.303
1961 Waldmann TA, Levin EH, Baldwin M. The association of polycythemia with a cerebellar hemangioblastoma. The production of an erythropoiesis stimulating factor by the tumor. The American Journal of Medicine. 31: 318-324. PMID 13782653 DOI: 10.1016/0002-9343(61)90120-6  0.318
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