Mark Bruce Lewandoski - Publications

Affiliations: 
1988 New York University, New York, NY, United States 
 1999- National Cancer Institute, Rockville, MD, United States 
Area:
Genetics of Vertebrate Development
Website:
https://ccr.cancer.gov/Cancer-and-Developmental-Biology-Laboratory/mark-b-lewandoski

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Anderson MJ, Misaghian S, Sharma N, Perantoni AO, Lewandoski M. Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis. Differentiation; Research in Biological Diversity. 130: 7-15. PMID 36527791 DOI: 10.1016/j.diff.2022.12.001  0.319
2021 Zelarayan L, Vendrell V, Domínguez-Frutos E, López-Hernández I, Schimmang-Alonso K, Alonso MT, Alvarez Y, Maier H, Anderson MJ, Lewandoski M, Schimmang T. Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 34719815 DOI: 10.1002/dvdy.435  0.354
2020 Boylan M, Anderson MJ, Ornitz DM, Lewandoski M. The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall. Development (Cambridge, England). PMID 32907848 DOI: 10.1242/Dev.189506  0.445
2020 Delgado I, López-Delgado AC, Roselló-Díez A, Giovinazzo G, Cadenas V, Fernández-de-Manuel L, Sánchez-Cabo F, Anderson MJ, Lewandoski M, Torres M. Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb. Science Advances. 6: eaaz0742. PMID 32537491 DOI: 10.1126/Sciadv.Aaz0742  0.364
2019 Hagan AS, Boylan M, Smith C, Perez-Santamarina E, Kowalska K, Hung IH, Lewis RM, Hajihosseini MK, Lewandoski M, Ornitz DM. Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18). Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 31290205 DOI: 10.1002/Dvdy.85  0.469
2018 Rodgers HM, Huffman VJ, Voronina VA, Lewandoski M, Mathers PH. The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification. Mechanisms of Development. PMID 29665410 DOI: 10.1016/J.Mod.2018.04.003  0.318
2018 Gao B, Ajima R, Yang W, Li C, Song H, Anderson MJ, Liu RR, Lewandoski MB, Yamaguchi TP, Yang Y. Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity. Development (Cambridge, England). PMID 29615464 DOI: 10.1242/Dev.163824  0.44
2017 Ulmer B, Tingler M, Kurz S, Maerker M, Andre P, Mönch D, Campione M, Deißler K, Lewandoski M, Thumberger T, Schweickert A, Fainsod A, Steinbeißer H, Blum M. A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse. Scientific Reports. 7: 43010. PMID 28220837 DOI: 10.1038/Srep43010  0.429
2016 Anderson MJ, Schimmang T, Lewandoski M. An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. Plos Genetics. 12: e1006018. PMID 27144312 DOI: 10.1371/Journal.Pgen.1006018  0.471
2016 Kaltcheva MM, Anderson MJ, Harfe BD, Lewandoski M. BMPs are direct triggers of interdigital programmed cell death. Developmental Biology. 411: 266-76. PMID 26826495 DOI: 10.1016/J.Ydbio.2015.12.016  0.47
2016 Hung IH, Schoenwolf GC, Lewandoski M, Ornitz DM. A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development. Developmental Biology. PMID 26794256 DOI: 10.1016/J.Ydbio.2016.01.008  0.504
2016 Anderson MJ, Southon E, Tessarollo L, Lewandoski M. Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development. Genesis (New York, N.Y. : 2000). 54: 91-8. PMID 26666435 DOI: 10.1002/Dvg.22913  0.476
2015 Morales AV, Espeso-Gil S, Ocaña I, Nieto-Lopez F, Calleja E, Bovolenta P, Lewandoski M, Diez Del Corral R. FGF signalling enhances a Sonic Hedgehog negative feedback loop at the initiation of spinal cord ventral patterning. Developmental Neurobiology. PMID 26600420 DOI: 10.1002/dneu.22368  0.344
2015 Herriges JC, Verheyden JM, Zhang Z, Sui P, Zhang Y, Anderson MJ, Swing DA, Zhang Y, Lewandoski M, Sun X. FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching. Developmental Cell. 35: 322-32. PMID 26555052 DOI: 10.1016/J.Devcel.2015.10.006  0.452
2015 Cunningham TJ, Brade T, Sandell LL, Lewandoski M, Trainor PA, Colas A, Mercola M, Duester G. Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis. Plos One. 10: e0137894. PMID 26368825 DOI: 10.1371/Journal.Pone.0137894  0.405
2015 Garriock RJ, Chalamalasetty RB, Kennedy MW, Canizales LC, Lewandoski M, Yamaguchi TP. Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation. Development (Cambridge, England). 142: 1628-38. PMID 25922526 DOI: 10.1242/Dev.111922  0.395
2014 Yun K, Ajima R, Sharma N, Costantini F, Mackem S, Lewandoski M, Yamaguchi TP, Perantoni AO. Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension. Human Molecular Genetics. 23: 6807-14. PMID 25082826 DOI: 10.1093/Hmg/Ddu397  0.458
2013 Sauer S, Burkett SS, Lewandoski M, Klar AJ. A CO-FISH assay to assess sister chromatid segregation patterns in mitosis of mouse embryonic stem cells. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 21: 311-28. PMID 23681662 DOI: 10.1007/S10577-013-9358-8  0.311
2013 Anderson MJ, Naiche LA, Wilson CP, Elder C, Swing DA, Lewandoski M. TCreERT2, a transgenic mouse line for temporal control of Cre-mediated recombination in lineages emerging from the primitive streak or tail bud. Plos One. 8: e62479. PMID 23638095 DOI: 10.1371/Journal.Pone.0062479  0.452
2013 Buckley DM, Burroughs-Garcia J, Lewandoski M, Waters ST. Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development. Plos One. 8: e56214. PMID 23418536 DOI: 10.1371/Journal.Pone.0056214  0.437
2013 Domyan ET, Branchfield K, Gibson DA, Naiche LA, Lewandoski M, Tessier-Lavigne M, Ma L, Sun X. Roundabout receptors are critical for foregut separation from the body wall. Developmental Cell. 24: 52-63. PMID 23328398 DOI: 10.1016/J.Devcel.2012.11.018  0.356
2012 Williams M, Burdsal C, Periasamy A, Lewandoski M, Sutherland A. Mouse primitive streak forms in situ by initiation of epithelial to mesenchymal transition without migration of a cell population Developmental Dynamics. 241: 270-283. PMID 22170865 DOI: 10.1002/Dvdy.23711  0.363
2011 Kitagaki J, Ueda Y, Chi X, Sharma N, Elder CM, Truffer E, Costantini F, Lewandoski M, Perantoni AO. FGF8 is essential for formation of the ductal system in the male reproductive tract. Development (Cambridge, England). 138: 5369-78. PMID 22110055 DOI: 10.1242/Dev.051888  0.5
2011 Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, Sahara S, O'Leary DD, Nakagawa Y, Lewandoski M, Pfaff S, Evans SM, Izpisua Belmonte JC. Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice. Development (Cambridge, England). 138: 4465-73. PMID 21937598 DOI: 10.1242/Dev.065359  0.445
2011 Naiche LA, Arora R, Kania A, Lewandoski M, Papaioannou VE. Identity and fate of Tbx4-expressing cells reveal developmental cell fate decisions in the allantois, limb, and external genitalia. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 240: 2290-300. PMID 21932311 DOI: 10.1002/Dvdy.22731  0.406
2011 Mackem S, Lewandoski M. Development. Limb cells don't tell time. Science (New York, N.Y.). 332: 1038-9. PMID 21617061 DOI: 10.1126/Science.1207554  0.395
2011 Naiche LA, Holder N, Lewandoski M. FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 4018-23. PMID 21368122 DOI: 10.1073/Pnas.1007417108  0.512
2011 Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X. The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning Developmental Biology. 351: 254-265. PMID 21256124 DOI: 10.1016/J.Ydbio.2011.01.005  0.341
2011 Lewandoski M, Mackem S. Developmental biology: extending the limb and body with vectors and scalars. Current Biology : Cb. 21: R34-6. PMID 21215936 DOI: 10.1016/J.Cub.2010.11.023  0.346
2011 Zacharias AL, Lewandoski M, Rudnicki MA, Gage PJ. Pitx2 is an upstream activator of extraocular myogenesis and survival Developmental Biology. 349: 395-405. PMID 21035439 DOI: 10.1016/J.Ydbio.2010.10.028  0.32
2011 Naiche L, Arora R, Papaioannou V, Lewandoski M. Lineage tracing of Tbx4-expressing cells reveals cryptic developmental decisions Developmental Biology. 356: 117. DOI: 10.1016/J.Ydbio.2011.05.055  0.331
2009 Lewandoski M, Mackem S. Limb development: the rise and fall of retinoic acid. Current Biology : Cb. 19: R558-61. PMID 19640492 DOI: 10.1016/J.Cub.2009.06.017  0.337
2009 Mackem S, Lewandoski M. Limb development takes a measured step toward systems analysis. Science Signaling. 2: pe33. PMID 19454648 DOI: 10.1126/Scisignal.271Pe33  0.501
2009 Tzchori I, Day TF, Carolan PJ, Zhao Y, Wassif CA, Li L, Lewandoski M, Gorivodsky M, Love PE, Porter FD, Westphal H, Yang Y. LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth. Development (Cambridge, England). 136: 1375-85. PMID 19304889 DOI: 10.1242/Dev.026476  0.398
2009 Yi L, Domyan ET, Lewandoski M, Sun X. Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 123-37. PMID 19097117 DOI: 10.1002/Dvdy.21831  0.354
2009 Kitagaki J, Ueda Y, Chi X, Costantini F, Elder C, Lewandoski M, Perantoni A. Program/Abstract # 186Fgf8 is essential for development of the male reproductive tract Developmental Biology. 331. DOI: 10.1016/J.Ydbio.2009.05.209  0.301
2009 Naiche LA, Holder N, Lewandoski MB. Fibroblast growth factors (FGFs) are required to maintain the presomitic mesoderm Developmental Biology. 331: 427. DOI: 10.1016/J.Ydbio.2009.05.146  0.349
2008 Kumar A, Lualdi M, Lewandoski M, Kuehn MR. Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 3591-601. PMID 18773491 DOI: 10.1002/Dvdy.21665  0.448
2008 Aulehla A, Wiegraebe W, Baubet V, Wahl MB, Deng C, Taketo M, Lewandoski M, Pourquié O. A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation. Nature Cell Biology. 10: 186-93. PMID 18157121 DOI: 10.1038/Ncb1679  0.341
2008 Dunty WC, Biris KK, Chalamalasetty RB, Taketo MM, Lewandoski M, Yamaguchi TP. Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development (Cambridge, England). 135: 85-94. PMID 18045842 DOI: 10.1242/Dev.009266  0.36
2008 Underwood S, Williams T, Mishina Y, Lewandoski M. In limb development BMP and FGF signaling interact through Sproutys Developmental Biology. 319: 498. DOI: 10.1016/J.Ydbio.2008.05.111  0.398
2007 Wahl MB, Deng C, Lewandoski M, Pourquié O. FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis. Development (Cambridge, England). 134: 4033-41. PMID 17965051 DOI: 10.1242/Dev.009167  0.439
2007 Jacques BE, Montcouquiol ME, Layman EM, Lewandoski M, Kelley MW. Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea. Development (Cambridge, England). 134: 3021-9. PMID 17634195 DOI: 10.1242/Dev.02874  0.434
2007 Pajni-Underwood S, Wilson CP, Elder C, Mishina Y, Lewandoski M. BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling. Development (Cambridge, England). 134: 2359-68. PMID 17537800 DOI: 10.1242/Dev.001677  0.504
2007 Holder ND, Wilson C, Elder C, Yamaguchi TP, Duester G, Lewandoski M. Fgf4 and Fgf8 are required for maintenance of the primitive streak and somitic clock Developmental Biology. 306: 401. DOI: 10.1016/J.Ydbio.2007.03.602  0.411
2007 Wilson C, Elder C, Duester G, Lewandoski M, Holder ND, Yamaguchi TP. WITHDRAWN: Fgf4 and Fgf8 are required for maintenance of the primitive streak and somitic clock Developmental Biology. DOI: 10.1016/J.Ydbio.2007.03.419  0.411
2007 Westphal H, Tzchori I, Day TF, Carolan PJ, Zhao Y, Wassif CA, Lewandoski M, Gorivodsky M. Ldb1, in conjunction with transcriptional regulators of the LIM-homeobox gene family, orchestrates limb patterning and outgrowth during mouse embryonic development Developmental Biology. 306: 357-358. DOI: 10.1016/J.Ydbio.2007.03.238  0.417
2007 Lewandoski M, Yamaguchi TP, Duester G, Holder N. Genetic analysis of FGF signaling in axis extension and somitogenesis Developmental Biology. 306: 334. DOI: 10.1016/J.Ydbio.2007.03.167  0.353
2007 Ueda Y, Lewandoski M, Plisov S, Wilson C, Sharma N, Elder C, Perantoni. Fgf8 is essential for development of the male reproductive tract Developmental Biology. 306: 306-307. DOI: 10.1016/J.Ydbio.2007.03.099  0.333
2006 Aggarwal VS, Liao J, Bondarev A, Schimmang T, Lewandoski M, Locker J, Shanske A, Campione M, Morrow BE. Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Human Molecular Genetics. 15: 3219-28. PMID 17000704 DOI: 10.1093/Hmg/Ddl399  0.512
2006 Winger Q, Huang J, Auman HJ, Lewandoski M, Williams T. Analysis of transcription factor AP-2 expression and function during mouse preimplantation development. Biology of Reproduction. 75: 324-33. PMID 16672719 DOI: 10.1095/biolreprod.106.052407  0.341
2006 Waters ST, Lewandoski M. A threshold requirement for Gbx2 levels in hindbrain development. Development (Cambridge, England). 133: 1991-2000. PMID 16651541 DOI: 10.1242/Dev.02364  0.43
2006 Pajni-Underwood S, Mishina Y, Williams T, Lewandoski M. BMP signaling is required for limb bud mesenchyme survival Developmental Biology. 295: 462. DOI: 10.1016/J.Ydbio.2006.04.423  0.329
2005 Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X. Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development (Cambridge, England). 132: 4235-45. PMID 16120640 DOI: 10.1242/Dev.02001  0.498
2005 Perantoni AO, Timofeeva O, Naillat F, Richman C, Pajni-Underwood S, Wilson C, Vainio S, Dove LF, Lewandoski M. Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development (Cambridge, England). 132: 3859-71. PMID 16049111 DOI: 10.1242/Dev.01945  0.496
2005 Voronina VA, Kozlov S, Mathers PH, Lewandoski M. Conditional alleles for activation and inactivation of the mouse Rx homeobox gene. Genesis (New York, N.Y. : 2000). 41: 160-4. PMID 15789424 DOI: 10.1002/Gene.20109  0.414
2003 Kim YS, Nakanishi G, Lewandoski M, Jetten AM. GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions. Nucleic Acids Research. 31: 5513-25. PMID 14500813 DOI: 10.1093/Nar/Gkg776  0.421
2003 Waters ST, Wilson CP, Lewandoski M. Cloning and embryonic expression analysis of the mouse Gbx1 gene. Gene Expression Patterns : Gep. 3: 313-7. PMID 12799077 DOI: 10.1016/S1567-133X(03)00041-3  0.459
2002 Kim YS, Lewandoski M, Perantoni AO, Kurebayashi S, Nakanishi G, Jetten AM. Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. The Journal of Biological Chemistry. 277: 30901-13. PMID 12042312 DOI: 10.1074/jbc.M203563200  0.328
2001 Lewandoski M. Conditional control of gene expression in the mouse. Nature Reviews. Genetics. 2: 743-55. PMID 11584291 DOI: 10.1038/35093537  0.366
2000 Cushman LJ, Burrows HL, Seasholtz AF, Lewandoski M, Muzyczka N, Camper SA. Cre-mediated recombination in the pituitary gland. Genesis (New York, N.Y. : 2000). 28: 167-74. PMID 11105060 DOI: 10.1002/1526-968X(200011/12)28:3/4<167::Aid-Gene120>3.0.Co;2-N  0.435
2000 Lewandoski M, Sun X, Martin GR. Fgf8 signalling from the AER is essential for normal limb development. Nature Genetics. 26: 460-3. PMID 11101846 DOI: 10.1038/82609  0.682
2000 Sun X, Lewandoski M, Meyers EN, Liu YH, Maxson RE, Martin GR. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nature Genetics. 25: 83-6. PMID 10802662 DOI: 10.1038/75644  0.676
1999 Sun X, Meyers EN, Lewandoski M, Martin GR. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes & Development. 13: 1834-46. PMID 10421635 DOI: 10.1101/Gad.13.14.1834  0.692
1999 Shelbourne PF, Killeen N, Hevner RF, Johnston HM, Tecott L, Lewandoski M, Ennis M, Ramirez L, Li Z, Iannicola C, Littman DR, Myers RM. A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice. Human Molecular Genetics. 8: 763-74. PMID 10196365 DOI: 10.1093/Hmg/8.5.763  0.338
1998 Grieshammer U, Lewandoski M, Prevette D, Oppenheim RW, Martin GR. Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss. Developmental Biology. 197: 234-47. PMID 9630749 DOI: 10.1006/Dbio.1997.8859  0.606
1998 Larsson NG, Wang J, Wilhelmsson H, Oldfors A, Rustin P, Lewandoski M, Barsh GS, Clayton DA. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nature Genetics. 18: 231-6. PMID 9500544 DOI: 10.1038/Ng0398-231  0.349
1998 Meyers EN, Lewandoski M, Martin GR. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nature Genetics. 18: 136-41. PMID 9462741 DOI: 10.1038/Ng0298-136  0.644
1998 Meyers EN, Lewandoski M, Martin GR. Generation and Analysis of Mice Carrying an Allelic Series of Mutations at the Fgf8 Locus Demonstrate Requirements for FGF8 During Gastrulation, Limb, Craniofacial, Cardiac and CNS Development • 286 Pediatric Research. 43: 51-51. DOI: 10.1203/00006450-199804001-00307  0.623
1997 Lewandoski M, Meyers EN, Martin GR. Analysis of Fgf8 gene function in vertebrate development. Cold Spring Harbor Symposia On Quantitative Biology. 62: 159-68. PMID 9598348  0.623
1997 Lewandoski M, Martin GR. Cre-mediated chromosome loss in mice. Nature Genetics. 17: 223-5. PMID 9326948 DOI: 10.1038/Ng1097-223  0.601
1997 Wassarman KM, Lewandoski M, Campbell K, Joyner AL, Rubenstein JL, Martinez S, Martin GR. Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development (Cambridge, England). 124: 2923-34. PMID 9247335  0.751
1997 Lewandoski M, Wassarman KM, Martin GR. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Current Biology : Cb. 7: 148-51. PMID 9016703 DOI: 10.1016/S0960-9822(06)00059-5  0.728
1997 Lewandoski M, Meyers EN, Martin GR. Analysis of Fgf8 Gene Function in Vertebrate Development Cold Spring Harbor Symposia On Quantitative Biology. 62: 159-168. DOI: 10.1101/Sqb.1997.062.01.021  0.468
1990 Bai U, Lewandoski M, Dubnau E, Smith I. Temporal regulation of the Bacillus subtilis early sporulation gene spo0F. Journal of Bacteriology. 172: 5432-9. PMID 2118512 DOI: 10.1128/Jb.172.9.5432-5439.1990  0.54
1988 Lewandoski M, Smith I. Use of a versatile lacZ vector to analyze the upstream region of the Bacillus subtilis spoOF gene. Plasmid. 20: 148-54. PMID 3148946 DOI: 10.1016/0147-619X(88)90018-2  0.551
1986 Lewandoski M, Dubnau E, Smith I. Transcriptional regulation of the spo0F gene of Bacillus subtilis. Journal of Bacteriology. 168: 870-7. PMID 2430944 DOI: 10.1128/Jb.168.2.870-877.1986  0.451
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