Thomas Franklin Westbrook - Publications

2008- Biochemistry and Molecular Biology Baylor College of Medicine, Houston, TX 
cancer research, genetics, technology, therapeutics

32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, ... ... Westbrook TF, et al. A druggable genome screen identifies modifiers of α-synuclein levels via a tiered cross-species validation approach. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30249792 DOI: 10.1523/JNEUROSCI.0254-18.2018  1
2018 Nair A, Chung HC, Sun T, Tyagi S, Dobrolecki LE, Dominguez-Vidana R, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Schmitt E, Chan DW, Li H, Mao S, ... ... Westbrook TF, et al. Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer. Nature Medicine. PMID 29578538 DOI: 10.1038/nm.4507  1
2018 Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, et al. Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. PMID 29576454 DOI: 10.1016/j.cell.2018.02.037  1
2017 Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, Liu Y, Tsang YH, de Velasco G, Jeong KJ, Akbani R, Hadjipanayis A, Pantazi A, Bristow CA, Lee E, Mahadeshwar HS, Tang J, ... ... Westbrook TF, et al. A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations. Cancer Cell. PMID 28528867 DOI: 10.1016/j.ccell.2017.04.013  1
2016 Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, ... ... Westbrook TF, et al. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nature Cell Biology. PMID 27183469 DOI: 10.1038/ncb3355  1
2015 Mahamdallie SS, Hanks S, Karlin KL, Zachariou A, R Perdeaux E, Ruark E, Shaw CA, Renwick A, Ramsay E, Yost S, Elliott A, Birch J, Capra M, Gray J, Hale J, ... ... Westbrook TF, et al. Mutations in the transcriptional repressor REST predispose to Wilms tumor. Nature Genetics. PMID 26551668 DOI: 10.1038/ng.3440  1
2015 Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, ... ... Westbrook TF, et al. The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. PMID 26331541 DOI: 10.1038/nature14985  1
2015 Izhar L, Adamson B, Ciccia A, Lewis J, Pontano-Vaites L, Leng Y, Liang AC, Westbrook TF, Harper JW, Elledge SJ. A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Reports. 11: 1486-500. PMID 26004182 DOI: 10.1016/j.celrep.2015.04.053  1
2015 He Y, Wu AC, Harrington BS, Davies CM, Wallace SJ, Adams MN, Palmer JS, Roche DK, Hollier BG, Westbrook TF, Hamidi H, Konecny GE, Winterhoff B, Chetty NP, Crandon AJ, et al. Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance. Oncogene. PMID 25893298 DOI: 10.1038/onc.2015.101  1
2015 Wang H, Yu C, Gao X, Welte T, Muscarella AM, Tian L, Zhao H, Zhao Z, Du S, Tao J, Lee B, Westbrook TF, Wong ST, Jin X, Rosen JM, et al. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell. 27: 193-210. PMID 25600338 DOI: 10.1016/j.ccell.2014.11.017  1
2014 Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, ... ... Westbrook TF, et al. The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Cell Reports. 9: 1318-32. PMID 25453754 DOI: 10.1016/j.celrep.2014.10.011  1
2014 Fu X, Creighton CJ, Biswal NC, Kumar V, Shea M, Herrera S, Contreras A, Gutierrez C, Wang T, Nanda S, Giuliano M, Morrison G, Nardone A, Karlin KL, Westbrook TF, et al. Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase. Breast Cancer Research : Bcr. 16: 430. PMID 25212826 DOI: 10.1186/s13058-014-0430-x  1
2014 Miao Q, Ku AT, Nishino Y, Howard JM, Rao AS, Shaver TM, Garcia GE, Le DN, Karlin KL, Westbrook TF, Poli V, Nguyen H. Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2. Nature Communications. 5: 4088. PMID 24909826 DOI: 10.1038/ncomms5088  1
2014 Villegas E, Kabotyanski EB, Shore AN, Creighton CJ, Westbrook TF, Rosen JM. Plk2 regulates mitotic spindle orientation and mammary gland development. Development (Cambridge, England). 141: 1562-71. PMID 24598160 DOI: 10.1242/dev.108258  1
2014 Terunuma A, Putluri N, Mishra P, Mathé EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, ... ... Westbrook TF, et al. MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. The Journal of Clinical Investigation. 124: 398-412. PMID 24316975 DOI: 10.1172/JCI71180  1
2013 Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, ... ... Westbrook TF, et al. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 498: 325-31. PMID 23719381 DOI: 10.1038/nature12204  1
2013 Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX. Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer Cell. 23: 725-38. PMID 23707782 DOI: 10.1016/j.ccr.2013.04.009  1
2013 Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ. A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife. 2: e00358. PMID 23682311 DOI: 10.7554/eLife.00358  1
2012 Dave B, Landis MD, Tweardy DJ, Chang JC, Dobrolecki LE, Wu MF, Zhang X, Westbrook TF, Hilsenbeck SG, Liu D, Lewis MT. Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. Plos One. 7: e30207. PMID 22879872 DOI: 10.1371/journal.pone.0030207  1
2012 Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL, Schmitt EM, Miller CR, Buckley AF, McLendon RE, Westbrook TF, et al. An animal model of MYC-driven medulloblastoma. Cancer Cell. 21: 155-67. PMID 22340590 DOI: 10.1016/j.ccr.2011.12.021  1
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Westbrook TF, et al. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (New York, N.Y.). 335: 348-53. PMID 22157079 DOI: 10.1126/science.1212728  1
2011 Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, ... ... Westbrook TF, et al. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 144: 703-18. PMID 21376233 DOI: 10.1016/j.cell.2011.02.003  1
2011 Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, ... ... Westbrook TF, et al. The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 3665-70. PMID 21307310 DOI: 10.1073/pnas.1019736108  1
2009 Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene Cell. 137: 835-848. PMID 19490893 DOI: 10.1016/j.cell.2009.05.006  1
2008 Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y. CDYL Bridges REST and Histone Methyltransferases for Gene Repression and Suppression of Cellular Transformation Molecular Cell. 32: 718-726. PMID 19061646 DOI: 10.1016/j.molcel.2008.10.025  1
2008 Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation Nature. 452: 370-374. PMID 18354483 DOI: 10.1038/nature06780  1
2008 Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, et al. Cancer proliferation gene discovery through functional genomics Science. 319: 620-624. PMID 18239126 DOI: 10.1126/science.1149200  1
2005 Westbrook TF, Stegmeier F, Elledge SJ. Dissecting cancer pathways and vulnerabilities with RNAi Cold Spring Harbor Symposia On Quantitative Biology. 70: 435-444. PMID 16869781 DOI: 10.1101/sqb.2005.70.031  1
2005 Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. A genetic screen for candidate tumor suppressors identifies REST. Cell. 121: 837-48. PMID 15960972 DOI: 10.1016/j.cell.2005.03.033  1
2004 Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, et al. A resource for large-scale RNA-interference-based screens in mammals. Nature. 428: 427-31. PMID 15042091 DOI: 10.1038/nature02370  1
2002 Westbrook TF, Nguyen DX, Thrash BR, McCance DJ. E7 abolishes raf-induced arrest via mislocalization of p21(Cip1). Molecular and Cellular Biology. 22: 7041-52. PMID 12242284 DOI: 10.1128/MCB.22.20.7041-7052.2002  1
2002 Nguyen DX, Westbrook TF, McCance DJ. Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest. Journal of Virology. 76: 619-32. PMID 11752153 DOI: 10.1128/JVI.76.2.619-632.2002  1
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