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Tyler R. Simpson, Ph.D. - Publications

Affiliations: 
2013 Weill Cornell Medical College, New York, NY, United States 
Area:
Immunology, Oncology, Cell Biology
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13 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hanson A, Elpek K, Duong E, Shallberg L, Fan M, Johnson C, Wallace M, Mabry GR, Sazinsky S, Pepper L, Shu CJ, Sathyanarayanan S, Zuerndorfer S, Simpson T, Gostissa M, et al. ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models. Plos One. 15: e0239595. PMID 32970735 DOI: 10.1371/journal.pone.0239595  0.53
2016 Elpek K, Harvey C, Duong E, Simpson T, Shu J, Shallberg L, Wallace M, Sathy S, Mabry R, Michaelson J, Briskin M. Abstract A059: Efficacy of anti-ICOS agonist monoclonal antibodies in preclinical tumor models provides a rationale for clinical development as cancer immunotherapeutics Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A059  0.627
2016 LeBleu VS, Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu C, Simpson T, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, Acosta AD, Sharma P, Heidari P, Mahmood U, et al. Abstract IA15: Functional diversity of the pancreas tumor stroma Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Ia15  0.602
2015 Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, et al. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell. 28: 831-833. PMID 28843279 DOI: 10.1016/J.Ccell.2015.11.002  0.443
2014 Pentcheva-Hoang T, Simpson TR, Montalvo-Ortiz W, Allison JP. Cytotoxic T lymphocyte antigen-4 blockade enhances antitumor immunity by stimulating melanoma-specific T-cell motility. Cancer Immunology Research. 2: 970-80. PMID 25038199 DOI: 10.1158/2326-6066.Cir-14-0104  0.693
2014 Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 25: 719-34. PMID 24856586 DOI: 10.1016/J.Ccr.2014.04.005  0.613
2013 Simpson TR, Li F, Montalvo-Ortiz W, Sepulveda MA, Bergerhoff K, Arce F, Roddie C, Henry JY, Yagita H, Wolchok JD, Peggs KS, Ravetch JV, Allison JP, Quezada SA. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. The Journal of Experimental Medicine. 210: 1695-710. PMID 23897981 DOI: 10.1084/Jem.20130579  0.694
2011 Quezada SA, Peggs KS, Simpson TR, Allison JP. Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication. Immunological Reviews. 241: 104-18. PMID 21488893 DOI: 10.1111/J.1600-065X.2011.01007.X  0.696
2010 Quezada SA, Simpson TR, Peggs KS, Merghoub T, Vider J, Fan X, Blasberg R, Yagita H, Muranski P, Antony PA, Restifo NP, Allison JP. Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. The Journal of Experimental Medicine. 207: 637-50. PMID 20156971 DOI: 10.1084/Jem.20091918  0.658
2010 Simpson TR, Quezada SA, Allison JP. Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS). Current Opinion in Immunology. 22: 326-32. PMID 20116985 DOI: 10.1016/J.Coi.2010.01.001  0.654
2008 Quezada SA, Peggs KS, Simpson TR, Shen Y, Littman DR, Allison JP. Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. The Journal of Experimental Medicine. 205: 2125-38. PMID 18725522 DOI: 10.1084/Jem.20080099  0.735
2007 Peggs KS, Quezada SA, Simpson TR, Allison JP. Dissociation of Systemic and Local Anti-Tumor Immunity Following Depletion of Regulatory T Cells Limits Therapeutic Activity in Established Tumors. Blood. 110: 286-286. DOI: 10.1182/Blood.V110.11.286.286  0.736
2006 Rivera A, Ro G, Van Epps HL, Simpson T, Leiner I, Sant'Angelo DB, Pamer EG. Innate immune activation and CD4+ T cell priming during respiratory fungal infection. Immunity. 25: 665-75. PMID 17027299 DOI: 10.1016/J.Immuni.2006.08.016  0.533
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