Jon Violin - Publications

1997-2003 UCSD School of Medicine, San Diego, CA, United States 

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Tarigopula M, Davis RT, Mungai PT, Ryba DM, Wieczorek DF, Cowan CL, Violin JD, Wolska BM, Solaro RJ. Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model. Cardiovascular Research. 107: 226-34. PMID 26045475 DOI: 10.1093/cvr/cvv162  0.6
2014 Soergel DG, Subach RA, Burnham N, Lark MW, James IE, Sadler BM, Skobieranda F, Violin JD, Webster LR. Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers. Pain. 155: 1829-35. PMID 24954166 DOI: 10.1016/j.pain.2014.06.011  0.6
2014 Violin JD, Crombie AL, Soergel DG, Lark MW. Biased ligands at G-protein-coupled receptors: Promise and progress Trends in Pharmacological Sciences. 35: 308-316. PMID 24878326 DOI: 10.1016/  0.6
2014 Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Rojas Bie Thomsen A, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). The Journal of Biological Chemistry. 289: 14211-24. PMID 24668815 DOI: 10.1074/jbc.M114.548131  0.6
2014 Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC. Intramolecular conformational changes optimize protein kinase C signaling. Chemistry & Biology. 21: 459-69. PMID 24631122 DOI: 10.1016/j.chembiol.2014.02.008  0.6
2014 Soergel DG, Subach RA, Sadler B, Connell J, Marion AS, Cowan CL, Violin JD, Lark MW. First clinical experience with TRV130: pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Clinical Pharmacology. 54: 351-7. PMID 24122908 DOI: 10.1002/jcph.207  0.6
2014 Violin JD, Crombie AL, Soergel DG, Lark MW. Biased ligands at G protein-coupled receptors: promise and progress. [Trends in Pharmacological Sciences 35 (2014) 308-316] (DOI:10.1016/ Trends in Pharmacological Sciences. DOI: 10.1016/  0.6
2013 Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, Rominger DH, Koblish M, Dewire SM, Crombie AL, Violin JD, Yamashita DS. Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain. Journal of Medicinal Chemistry. 56: 8019-31. PMID 24063433 DOI: 10.1021/jm4010829  0.6
2013 Monasky MM, Taglieri DM, Henze M, Warren CM, Utter MS, Soergel DG, Violin JD, Solaro RJ. The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium. American Journal of Physiology. Heart and Circulatory Physiology. 305: H856-66. PMID 23873795 DOI: 10.1152/ajpheart.00327.2013  0.6
2013 Soergel DG, Subach RA, Cowan CL, Violin JD, Lark MW. First clinical experience with TRV027: Pharmacokinetics and pharmacodynamics in healthy volunteers Journal of Clinical Pharmacology. 53: 892-899. PMID 23813302 DOI: 10.1002/jcph.111  0.6
2013 Violin JD, Soergel DG, Boerrigter G, Burnett JC, Lark MW. GPCR biased ligands as novel heart failure therapeutics. Trends in Cardiovascular Medicine. 23: 242-9. PMID 23499300 DOI: 10.1016/j.tcm.2013.01.002  0.6
2013 DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD. A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. The Journal of Pharmacology and Experimental Therapeutics. 344: 708-17. PMID 23300227 DOI: 10.1124/jpet.112.201616  0.6
2012 Boerrigter G, Soergel DG, Violin JD, Lark MW, Burnett JC. TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure. Circulation. Heart Failure. 5: 627-34. PMID 22891045 DOI: 10.1161/CIRCHEARTFAILURE.112.969220  0.6
2012 Kim KS, Abraham D, Williams B, Violin JD, Mao L, Rockman HA. β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury. American Journal of Physiology. Heart and Circulatory Physiology. 303: H1001-10. PMID 22886417 DOI: 10.1152/ajpheart.00475.2012  0.6
2012 Heitzler D, Durand G, Gallay N, Rizk A, Ahn S, Kim J, Violin JD, Dupuy L, Gauthier C, Piketty V, Crépieux P, Poupon A, Clément F, Fages F, Lefkowitz RJ, et al. Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. Molecular Systems Biology. 8: 590. PMID 22735336 DOI: 10.1038/msb.2012.22  0.6
2012 Violin JD, Soergel DG, Lark MW. Beta-arrestin-biased ligands at the AT1R: A novel approach to the treatment of acute heart failure Drug Discovery Today: Therapeutic Strategies. 9. DOI: 10.1016/j.ddstr.2014.01.001  0.6
2011 Boerrigter G, Lark MW, Whalen EJ, Soergel DG, Violin JD, Burnett JC. Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure. Circulation. Heart Failure. 4: 770-8. PMID 21835984 DOI: 10.1161/CIRCHEARTFAILURE.111.962571  0.6
2011 DeWire SM, Violin JD. Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology. Circulation Research. 109: 205-16. PMID 21737816 DOI: 10.1161/CIRCRESAHA.110.231308  0.6
2011 Rajagopal S, Ahn S, Rominger DH, Gowen-MacDonald W, Lam CM, Dewire SM, Violin JD, Lefkowitz RJ. Quantifying ligand bias at seven-transmembrane receptors. Molecular Pharmacology. 80: 367-77. PMID 21610196 DOI: 10.1124/mol.111.072801  0.6
2010 Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW. Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance. The Journal of Pharmacology and Experimental Therapeutics. 335: 572-9. PMID 20801892 DOI: 10.1124/jpet.110.173005  0.6
2009 Tilley DG, Kim IM, Patel PA, Violin JD, Rockman HA. beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling. The Journal of Biological Chemistry. 284: 20375-86. PMID 19509284 DOI: 10.1074/jbc.M109.005793  0.6
2009 Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ. Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proceedings of the National Academy of Sciences of the United States of America. 106: 9649-54. PMID 19497875 DOI: 10.1073/pnas.0904361106  0.6
2009 Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ. beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. The Journal of Clinical Investigation. 119: 1312-21. PMID 19349687 DOI: 10.1172/JCI36806  0.6
2008 Kim IM, Tilley DG, Chen J, Salazar NC, Whalen EJ, Violin JD, Rockman HA. Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proceedings of the National Academy of Sciences of the United States of America. 105: 14555-60. PMID 18787115 DOI: 10.1073/pnas.0804745105  0.6
2008 Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ. Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 9988-93. PMID 18621717 DOI: 10.1073/pnas.0804246105  0.6
2008 Barak LS, Salahpour A, Zhang X, Masri B, Sotnikova TD, Ramsey AJ, Violin JD, Lefkowitz RJ, Caron MG, Gainetdinov RR. Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. Molecular Pharmacology. 74: 585-94. PMID 18524885 DOI: 10.1124/mol.108.048884  0.6
2008 Drake MT, Violin JD, Whalen EJ, Wisler JW, Shenoy SK, Lefkowitz RJ. beta-arrestin-biased agonism at the beta2-adrenergic receptor. The Journal of Biological Chemistry. 283: 5669-76. PMID 18086673 DOI: 10.1074/jbc.M708118200  0.6
2008 Violin JD, DiPilato LM, Yildirim N, Elston TC, Zhang J, Lefkowitz RJ. beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. The Journal of Biological Chemistry. 283: 2949-61. PMID 18045878 DOI: 10.1074/jbc.M707009200  0.6
2007 Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16657-62. PMID 17925438 DOI: 10.1073/pnas.0707936104  0.6
2007 Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman HA. Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. The Journal of Clinical Investigation. 117: 2445-58. PMID 17786238 DOI: 10.1172/JCI31901  0.6
2007 Violin JD, Lefkowitz RJ. Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends in Pharmacological Sciences. 28: 416-22. PMID 17644195 DOI: 10.1016/  0.6
2007 Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 129: 511-22. PMID 17482545 DOI: 10.1016/j.cell.2007.02.046  0.6
2006 Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman HA, Lefkowitz RJ. Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 16284-9. PMID 17060617 DOI: 10.1073/pnas.0607583103  0.6
2006 Violin JD, Dewire SM, Barnes WG, Lefkowitz RJ. G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. The Journal of Biological Chemistry. 281: 36411-9. PMID 17008309 DOI: 10.1074/jbc.M607956200  0.6
2006 Violin JD, Ren XR, Lefkowitz RJ. G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. The Journal of Biological Chemistry. 281: 20577-88. PMID 16687412 DOI: 10.1074/jbc.M513605200  0.6
2005 Hunton DL, Barnes WG, Kim J, Ren XR, Violin JD, Reiter E, Milligan G, Patel DD, Lefkowitz RJ. Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Molecular Pharmacology. 67: 1229-36. PMID 15635042 DOI: 10.1124/mol.104.006270  0.6
2005 Barnes WG, Reiter E, Violin JD, Ren XR, Milligan G, Lefkowitz RJ. beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. The Journal of Biological Chemistry. 280: 8041-50. PMID 15611106 DOI: 10.1074/jbc.M412924200  0.6
2003 Violin JD, Newton AC. Pathway illuminated: visualizing protein kinase C signaling. Iubmb Life. 55: 653-60. PMID 14769001 DOI: 10.1080/152165401310001642216  0.6
2003 Qiao D, Seidler FJ, Violin JD, Slotkin TA. Nicotine is a developmental neurotoxicant and neuroprotectant: Stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos Developmental Brain Research. 147: 183-190. PMID 14741763 DOI: 10.1016/S0165-3806(03)00222-0  0.6
2003 Violin JD, Zhang J, Tsien RY, Newton AC. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. The Journal of Cell Biology. 161: 899-909. PMID 12782683 DOI: 10.1083/jcb.200302125  0.6
2002 Zacharias DA, Violin JD, Newton AC, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science (New York, N.Y.). 296: 913-6. PMID 11988576 DOI: 10.1126/science.1068539  0.6
2000 Ostrom RS, Violin JD, Coleman S, Insel PA. Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes. Molecular Pharmacology. 57: 1075-9. PMID 10779394  0.6
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