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Andras Malnasi-Csizmadia - Publications

Affiliations: 
1994-1999 Biochemistry Eötvös Loránd University 
 1999-2003 Biochemistry University of Leicester, Leicester, England, United Kingdom 
 2004- Biochemistry Eötvös Loránd University 
Website:
http://malnalab.hu/whatss-new/
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62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Suthar SK, Rauscher AÁ, Winternitz M, Gyimesi M, Málnási-Csizmadia A. Chiral HPLC separation of enantiomeric blebbistatin derivatives and racemization analysis in vertebrate tissues. Journal of Pharmaceutical and Biomedical Analysis. 204: 114246. PMID 34271288 DOI: 10.1016/j.jpba.2021.114246  0.63
2021 Gyimesi M, Rauscher AÁ, Suthar SK, Hamow KÁ, Oravecz K, Lőrincz I, Borhegyi Z, Déri MT, Kiss ÁF, Monostory K, Szabó PT, Nag S, Tomasic I, Krans J, Tierney PJ, et al. . The Journal of Pharmacology and Experimental Therapeutics. PMID 33468641 DOI: 10.1124/jpet.120.000167  0.741
2020 Gyimesi M, Horváth ÁI, Túrós D, Suthar SK, Pénzes M, Kurdi C, Canon L, Kikuti C, Ruppel KM, Trivedi DV, Spudich JA, Lőrincz I, Rauscher AÁ, Kovács M, Pál E, et al. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell. PMID 33035452 DOI: 10.1016/j.cell.2020.08.050  0.746
2020 Harami GM, Kovács ZJ, Pancsa R, Pálinkás J, Baráth V, Tárnok K, Málnási-Csizmadia A, Kovács M. Phase separation by ssDNA binding protein controlled via protein-protein and protein-DNA interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 33020264 DOI: 10.1073/pnas.2000761117  0.548
2020 Horváth ÁI, Gyimesi M, Várkuti BH, Képiró M, Szegvári G, Lőrincz I, Hegyi G, Kovács M, Málnási-Csizmadia A. Effect of allosteric inhibition of non-muscle myosin 2 on its intracellular diffusion. Scientific Reports. 10: 13341. PMID 32769996 DOI: 10.1038/S41598-020-69853-8  0.736
2020 Pénzes M, Túrós D, Máthé D, Szigeti K, Hegedűs N, Rauscher AÁ, Tóth P, Ivic I, Padmanabhan P, Pál G, Dobolyi Á, Gyimesi M, Málnási-Csizmadia A. Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke. Theranostics. 10: 5341-5356. PMID 32373216 DOI: 10.7150/Thno.42077  0.683
2020 López-Dávila AJ, Chalovich JM, Zittrich S, Piep B, Matinmehr F, Málnási-Csizmadia A, Rauscher AÁ, Kraft T, Brenner B, Stehle R. Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers. Frontiers in Physiology. 11: 144. PMID 32265723 DOI: 10.3389/Fphys.2020.00144  0.366
2020 Suthar SK, Gyimesi M, Kurdi C, Malnasi-Csizmadia A. SAR Analysis of Linker Derivatives of the Smooth Muscle Myosin Specific CK-571 Compound Biophysical Journal. 118: 495a. DOI: 10.1016/J.Bpj.2019.11.2737  0.683
2020 Harami G, Kovacs ZJ, Pálinkás J, Pancsa R, Baráth V, Tárnok K, Harami-Papp H, Malnasi-Csizmadia A, Kovacs M. E. coli Single-Stranded DNA Binding (SSB) Protein Undergoes Dynamic Liquid-Liquid Phase Separation Controlled via Protein-Protein and Protein-DNA Interactions Biophysical Journal. 118: 484a. DOI: 10.1016/J.Bpj.2019.11.2680  0.563
2020 Túrós D, Horvath AI, Gyimesi M, Malnasi-Csizmadia A. 3D Movement Analysis using Deep Learning Algorithms Reveals Alterations in Motor Functions After Neurological Injuries in RAT Spasticity Model Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2565  0.658
2020 Penzes M, Turos D, Winternitz M, Ivic I, Toth P, Rauscher AÁ, Gyimesi M, Malnasi-Csizmadia A. Targeted Myosin-2 Inhibition Improves Brain Regeneration After Stroke by Relaxing Hypoxia-Induced Vasoconstriction in Capillaries Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2439  0.674
2020 Gyimesi M, Horvath AI, Túrós D, Hegyi G, Suthar SK, Kovacs M, Malnasi-Csizmadia A. The New-Generation Muscle Relaxant MPH-220 Dissolves Spasticity in Muscles After Cns Injury - a Promising Drug to Address Post-Stroke Spasticity Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2438  0.746
2018 Rauscher AÁ, Gyimesi M, Kovács M, Málnási-Csizmadia A. Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential. Trends in Biochemical Sciences. PMID 30057142 DOI: 10.1016/J.Tibs.2018.06.006  0.759
2018 Lukacs P, Földi MC, Valánszki L, Casanova E, Biri-Kovács B, Nyitray L, Málnási-Csizmadia A, Mike A. Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog. Scientific Reports. 8: 8110. PMID 29802266 DOI: 10.1038/S41598-018-26444-Y  0.594
2017 Horvath AI, Varkuti BH, Kepiro M, Hegyi G, Kovacs M, Malnasi-Csizmadia A. Subcellular Spatial Control of Non-Muscle Myosin 2 Redistribution and Stress Fiber Strain by Molecular Tattoo Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.2297  0.594
2016 Tang W, Blair CA, Walton SD, Málnási-Csizmadia A, Campbell KS, Yengo CM. Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels. Frontiers in Physiology. 7: 659. PMID 28119616 DOI: 10.3389/Fphys.2016.00659  0.357
2016 Várkuti BH, Képiró M, Horváth IÁ, Végner L, Ráti S, Zsigmond Á, Hegyi G, Lenkei Z, Varga M, Málnási-Csizmadia A. A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. Scientific Reports. 6: 26141. PMID 27241904 DOI: 10.1038/Srep26141  0.369
2015 Várkuti BH, Yang Z, Malnasi-Csizmadia A. Structural model of weak binding actomyosin in the prepowerstroke state. The Journal of Biological Chemistry. 290: 1679-88. PMID 25416786 DOI: 10.1074/Jbc.M114.606665  0.437
2014 Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, Málnási-Csizmadia A, Debold EP, Yengo CM. Magnesium modulates actin binding and ADP release in myosin motors. The Journal of Biological Chemistry. 289: 23977-91. PMID 25006251 DOI: 10.1074/Jbc.M114.562231  0.417
2014 Képiró M, Várkuti BH, Végner L, Vörös G, Hegyi G, Varga M, Málnási-Csizmadia A. para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor. Angewandte Chemie (International Ed. in English). 53: 8211-5. PMID 24954740 DOI: 10.1002/Anie.201403540  0.336
2014 Lörincz IZ, Schay G, Rauscher AÁ, Kellermayer MS, Gensch M, Malnasi-Csizmadia A. Non-Thermal Induction of Conforamtional Rearrangment in Proteins by Far-Infrared Excitation Biophysical Journal. 106: 460a. DOI: 10.1016/J.Bpj.2013.11.2608  0.301
2013 Képiró M, Várkuti BH, Hegyi G, Kovács M, Málnási-Csizmadia A. Interactomics of Blebbistatin Biophysical Journal. 104: 403a-404a. DOI: 10.1016/J.Bpj.2012.11.2252  0.638
2013 Várkuti BH, Zenhui Y, Rauscher AÁ, Málnási-Csizmadia A. A Structural Model of Actomyosin in the Prepowerstroke State: Actin Binding Induced Extra Priming of Myosin Biophysical Journal. 104: 307a-308a. DOI: 10.1016/J.Bpj.2012.11.1710  0.447
2012 Képiró M, Várkuti BH, Bodor A, Hegyi G, Drahos L, Kovács M, Málnási-Csizmadia A. Azidoblebbistatin, a photoreactive myosin inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 109: 9402-7. PMID 22647605 DOI: 10.1073/Pnas.1202786109  0.651
2012 Várkuti BH, Yang Z, Kintses B, Erdélyi P, Bárdos-Nagy I, Kovács AL, Hári P, Kellermayer M, Vellai T, Málnási-Csizmadia A. A novel actin binding site of myosin required for effective muscle contraction. Nature Structural & Molecular Biology. 19: 299-306. PMID 22343723 DOI: 10.1038/Nsmb.2216  0.763
2012 Képiró M, Várkuti BH, Hegyi G, Kovács M, Málnási-Csizmadia A. Synthesis and Functional Characterization of Azido-Blebbistatin, a Photoreactive Myosin Inhibitor Biophysical Journal. 102: 159a. DOI: 10.1016/J.Bpj.2011.11.865  0.627
2012 Zhenhui Y, Varkuti B, Rauscher A, Kepiro M, Malnasi-Csizmadia A. Structural Model of the Pre-Powerstroke State of the Actomyosin Complex Biophysical Journal. 102: 16a. DOI: 10.1016/J.Bpj.2011.11.113  0.469
2011 Purcell TJ, Naber N, Franks-Skiba K, Dunn AR, Eldred CC, Berger CL, Málnási-Csizmadia A, Spudich JA, Swank DM, Pate E, Cooke R. Nucleotide pocket thermodynamics measured by EPR reveal how energy partitioning relates myosin speed to efficiency. Journal of Molecular Biology. 407: 79-91. PMID 21185304 DOI: 10.1016/J.Jmb.2010.11.053  0.431
2011 Varkuti B, Yang Z, Kintses B, Erdelyi P, Vellai T, Kellermayer M, Malnasi-Csizmadia A. A Novel Actin Binding Site of Myosin is Responsible for Effective Muscle Contraction Biophysical Journal. 100: 130a-131a. DOI: 10.1016/J.Bpj.2010.12.917  0.768
2010 Simon Z, Vigh-Smeller M, Peragovics A, Csukly G, Zahoránszky-Kohalmi G, Rauscher AA, Jelinek B, Hári P, Bitter I, Málnási-Csizmadia A, Czobor P. Relating the shape of protein binding sites to binding affinity profiles: is there an association? Bmc Structural Biology. 10: 32. PMID 20923553 DOI: 10.1186/1472-6807-10-32  0.345
2010 Málnási-Csizmadia A, Kovács M. Emerging complex pathways of the actomyosin powerstroke. Trends in Biochemical Sciences. 35: 684-90. PMID 20801044 DOI: 10.1016/J.Tibs.2010.07.012  0.639
2010 Takács B, Billington N, Gyimesi M, Kintses B, Málnási-Csizmadia A, Knight PJ, Kovács M. Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke. Proceedings of the National Academy of Sciences of the United States of America. 107: 6799-804. PMID 20351242 DOI: 10.1073/Pnas.0907585107  0.796
2010 Naber N, Málnási-Csizmadia A, Purcell TJ, Cooke R, Pate E. Combining EPR with fluorescence spectroscopy to monitor conformational changes at the myosin nucleotide pocket. Journal of Molecular Biology. 396: 937-48. PMID 20036250 DOI: 10.1016/J.Jmb.2009.12.035  0.461
2010 Derenyi I, Rauscher A, Szollosi GJ, Simon Z, Graf L, Malnasi-Csizmadia A. The Relative Significance of External and Internal Friction in Protein Conformational Changes Biophysical Journal. 98: 237a. DOI: 10.1016/J.Bpj.2009.12.1287  0.336
2008 Kintses B, Yang Z, Málnási-Csizmadia A. Experimental investigation of the seesaw mechanism of the relay region that moves the myosin lever arm. The Journal of Biological Chemistry. 283: 34121-8. PMID 18854311 DOI: 10.1074/Jbc.M805848200  0.758
2008 Gyimesi M, Kintses B, Bodor A, Perczel A, Fischer S, Bagshaw CR, Málnási-Csizmadia A. The mechanism of the reverse recovery step, phosphate release, and actin activation of Dictyostelium myosin II. The Journal of Biological Chemistry. 283: 8153-63. PMID 18211892 DOI: 10.1074/Jbc.M708863200  0.79
2008 Gyimesi M, Tsaturyan AK, Kellermayer MS, Málnási-Csizmadia A. Kinetic characterization of the function of myosin loop 4 in the actin-myosin interaction. Biochemistry. 47: 283-91. PMID 18067324 DOI: 10.1021/Bi701554A  0.753
2007 Tóth J, Varga B, Kovács M, Málnási-Csizmadia A, Vértessy BG. Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme. The Journal of Biological Chemistry. 282: 33572-82. PMID 17848562 DOI: 10.1074/Jbc.M706230200  0.623
2007 Málnási-Csizmadia A, Tóth J, Pearson DS, Hetényi C, Nyitray L, Geeves MA, Bagshaw CR, Kovács M. Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release. The Journal of Biological Chemistry. 282: 17658-64. PMID 17449872 DOI: 10.1074/Jbc.M701447200  0.791
2007 Tóth J, Simon Z, Medveczky P, Gombos L, Jelinek B, Szilágyi L, Gráf L, Málnási-Csizmadia A. Site directed mutagenesis at position 193 of human trypsin 4 alters the rate of conformational change during activation: role of local internal viscosity in protein dynamics. Proteins. 67: 1119-27. PMID 17436323 DOI: 10.1002/Prot.21398  0.336
2007 Kintses B, Gyimesi M, Pearson DS, Geeves MA, Zeng W, Bagshaw CR, Málnási-Csizmadia A. Reversible movement of switch 1 loop of myosin determines actin interaction. The Embo Journal. 26: 265-74. PMID 17213877 DOI: 10.1038/Sj.Emboj.7601482  0.79
2007 Fajer PG, Gyimesi M, Málnási-Csizmadia A, Bagshaw CR, Ilker Sen K, Song L. Myosin cleft closure by double electron-electron resonance and dipolar EPR Journal of Physics Condensed Matter. 19. DOI: 10.1088/0953-8984/19/28/285208  0.783
2006 Kintses B, Simon Z, Gyimesi M, Tóth J, Jelinek B, Niedetzky C, Kovács M, Málnási-Csizmadia A. Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus. Biophysical Journal. 91: 4605-10. PMID 17012324 DOI: 10.1529/Biophysj.106.092833  0.739
2006 Zeng W, Seward HE, Málnási-Csizmadia A, Wakelin S, Woolley RJ, Cheema GS, Basran J, Patel TR, Rowe AJ, Bagshaw CR. Resonance energy transfer between green fluorescent protein variants: complexities revealed with myosin fusion proteins. Biochemistry. 45: 10482-91. PMID 16939200 DOI: 10.1021/Bi060943U  0.578
2006 Tóth J, Gombos L, Simon Z, Medveczky P, Szilágyi L, Gráf L, Málnási-Csizmadia A. Thermodynamic analysis reveals structural rearrangement during the acylation step in human trypsin 4 on 4-methylumbelliferyl 4-guanidinobenzoate substrate analogue. The Journal of Biological Chemistry. 281: 12596-602. PMID 16492676 DOI: 10.1074/Jbc.M512301200  0.341
2005 Málnási-Csizmadia A, Dickens JL, Zeng W, Bagshaw CR. Switch movements and the myosin crossbridge stroke. Journal of Muscle Research and Cell Motility. 26: 31-7. PMID 16075160 DOI: 10.1007/S10974-005-9004-Y  0.634
2004 Zeng W, Conibear PB, Dickens JL, Cowie RA, Wakelin S, Málnási-Csizmadia A, Bagshaw CR. Dynamics of actomyosin interactions in relation to the cross-bridge cycle. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 359: 1843-55. PMID 15647160 DOI: 10.1098/Rstb.2004.1527  0.678
2004 Conibear PB, Málnási-Csizmadia A, Bagshaw CR. The effect of F-actin on the relay helix position of myosin II, as revealed by tryptophan fluorescence, and its implications for mechanochemical coupling. Biochemistry. 43: 15404-17. PMID 15581352 DOI: 10.1021/Bi048338J  0.662
2004 Nagy A, Cacciafesta P, Grama L, Kengyel A, Málnási-Csizmadia A, Kellermayer MS. Differential actin binding along the PEVK domain of skeletal muscle titin. Journal of Cell Science. 117: 5781-9. PMID 15507486 DOI: 10.1242/Jcs.01501  0.44
2004 Bódis E, Strambini GB, Gonnelli M, Málnási-Csizmadia A, Somogyi B. Characterization of f-actin tryptophan phosphorescence in the presence and absence of tryptophan-free myosin motor domain. Biophysical Journal. 87: 1146-54. PMID 15298917 DOI: 10.1529/Biophysj.104.041855  0.455
2004 Kovács M, Tóth J, Hetényi C, Málnási-Csizmadia A, Sellers JR. Mechanism of blebbistatin inhibition of myosin II. The Journal of Biological Chemistry. 279: 35557-63. PMID 15205456 DOI: 10.1074/Jbc.M405319200  0.69
2004 Kovács M, Tóth J, Málnási-Csizmadia A, Bagshaw CR, Nyitray L. Engineering lysine reactivity as a conformational sensor in the Dictyostelium myosin II motor domain. Journal of Muscle Research and Cell Motility. 25: 95-102. PMID 15160493 DOI: 10.1023/B:Jure.0000021352.80800.B8  0.797
2004 Málnási-Csizmadia A, Pearson DS, Kovács M, Woolley RJ, Geeves MA, Bagshaw CR. Kinetic Resolution of a Conformational Transition and the ATP Hydrolysis Step Using Relaxation Methods with aDictyosteliumMyosin II Mutant Containing a Single Tryptophan Residue Biochemistry. 43: 14316-14316. DOI: 10.1021/Bi040043I  0.724
2003 Conibear PB, Bagshaw CR, Fajer PG, Kovács M, Málnási-Csizmadia A. Myosin cleft movement and its coupling to actomyosin dissociation. Nature Structural Biology. 10: 831-5. PMID 14502269 DOI: 10.1038/Nsb986  0.763
2003 Farkas L, Malnasi-Csizmadia A, Nakamura A, Kohama K, Nyitray L. Localization and characterization of the inhibitory Ca2+-binding site of Physarum polycephalum myosin II. The Journal of Biological Chemistry. 278: 27399-405. PMID 12754206 DOI: 10.1074/Jbc.M304220200  0.646
2002 Wakelin S, Conibear PB, Woolley RJ, Floyd DN, Bagshaw CR, Kovács M, Málnási-Csizmadia A. Engineering Dictyostelium discoideum myosin II for the introduction of site-specific fluorescence probes. Journal of Muscle Research and Cell Motility. 23: 673-83. PMID 12952066 DOI: 10.1023/A:1024411208497  0.738
2002 Kovacs M, Malnasi-Csizmadia A, Woolley RJ, Bagshaw CR. Analysis of nucleotide binding to Dictyostelium myosin II motor domains containing a single tryptophan near the active site. The Journal of Biological Chemistry. 277: 28459-67. PMID 11971905 DOI: 10.1074/Jbc.M202180200  0.771
2001 Málnási-Csizmadia A, Pearson DS, Kovács M, Woolley RJ, Geeves MA, Bagshaw CR. Kinetic resolution of a conformational transition and the ATP hydrolysis step using relaxation methods with a Dictyostelium myosin II mutant containing a single tryptophan residue. Biochemistry. 40: 12727-37. PMID 11601998 DOI: 10.1021/Bi010963Q  0.747
2001 Malnasi-Csizmadia A, Kovacs M, Woolley RJ, Botchway SW, Bagshaw CR. The dynamics of the relay loop tryptophan residue in the Dictyostelium myosin motor domain and the origin of spectroscopic signals. The Journal of Biological Chemistry. 276: 19483-90. PMID 11278775 DOI: 10.1074/Jbc.M010886200  0.731
2001 Málnási-Csizmadia A, Woolley RJ, Bagshaw CR. Resolution of conformational states of Dictyostelium myosin II motor domain using tryptophan (W501) mutants: implications for the open-closed transition identified by crystallography. Biochemistry. 39: 16135-46. PMID 11123942 DOI: 10.1021/Bi001125J  0.677
1999 Málnási-Csizmadia A, Hegyi G, Tölgyesi F, Szent-Györgyi AG, Nyitray L. Fluorescence measurements detect changes in scallop myosin regulatory domain. European Journal of Biochemistry / Febs. 261: 452-8. PMID 10215856 DOI: 10.1046/J.1432-1327.1999.00290.X  0.752
1998 Málnási-Csizmadia A, Shimony E, Hegyi G, Szent-Györgyi AG, Nyitray L. Dimerization of the head-rod junction of scallop myosin. Biochemical and Biophysical Research Communications. 252: 595-601. PMID 9837752 DOI: 10.1006/Bbrc.1998.9603  0.744
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